Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Sequence features for peptidase M24.005: aminopeptidase P2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Metal ligands Source
MER0689901 Acanthisitta chloris 661 344-586 H415, H505, H518, D435, D446, H509, E540, E554, GENBANK:XP_009072149
MER0269999 Ailuropoda melanoleuca 686 353-615 H442, H532, H545 D462, D473, H536, E567, E581 GENBANK:XP_002918635
MER0291316 Alligator mississippiensis 679 353-606 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_006262285
MER0299918 Alligator sinensis 679 353-606 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_006027605
MER0481669 Anolis carolinensis 811 486-740 H564, H654, H667 D584, D595, H658, E689, E703 GENBANK:XP_003227142
MER0687182 Aptenodytes forsteri 652 381-577 H406, H491, H504 G426, D432, H495, E526, E540 GENBANK:XP_009282888
MER0686870 Aquila chrysaetos 683 351-605 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_011598084
MER0554701 Astatotilapia burtoni 710 387-637 H464, H554, H567 D484, D495, H558, E589, E603 GENBANK:XP_005913229
MER0364392 Astyanax mexicanus 661 381-582 H458, H548, H561 D478, D489, H552, missing, missing GENBANK:XP_007254515
MER0399103 Balaenoptera acutorostrata 657 321-572 H399, H489, H502 D419, D430, H493, E524, E538 GENBANK:XP_007181043
MER0678979 Bison bison 223 169-223 missing, missing, missing missing, missing, missing, missing, missing GENBANK:XP_010850453
MER0678987 Bison bison 98 1-79 missing, H19, H32 missing, missing, H23, E54, E68 GENBANK:XP_010851646
MER0428188 Bos grunniens 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 UNIPROT:L8HSB1
MER0428188 Bos grunniens 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 UNIPROT:L8HSB1
MER0166707 Bos taurus 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_580998
MER0580195 Bubalus bubalis 676 351-605 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_006065710
MER0481642 Callithrix jacchus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_002763295
MER0581764 Calypte anna 636 330-584 H408, H498, H511 D428, D439, H502, E533, E547 GENBANK:XP_008498321
MER0677790 Camelus dromedarius 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_010989877
MER0430856 Camelus ferus 479 226-408 H235, H325, H338 D255, D266, H329, E360, E374 GENBANK:XP_006191951
MER0523236 Capra hircus 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_005700427
MER0003107 Cavia porcellus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_003462286
MER0003108 Cavia porcellus 24 1-24 missing, missing, missing missing, missing, missing, missing, missing PIR:PC2312
MER0518137 Ceratotherium simum 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_004437362
MER0585487 Cercopithecus sabaeus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_007990846
MER0673372 Chaetura pelagica 517 197-446 H275, H365, H378 D295, D306, H369, E400, E414 GENBANK:XP_010001767
MER0591314 Chelonia mydas 659 365-593 H443, H533, H546 D463, D474, H537, E568, E582 GENBANK:XP_007063879
MER0583988 Chinchilla lanigera 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_005401316
MER0578038 Chrysemys picta 679 353-606 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_005310962
MER0574811 Chrysochloris asiatica 675 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_006862897
MER0669140 Colobus angolensis 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_011792362
MER0578685 Columba livia 668 343-592 H421, H511, H524 D441, D452, H515, E546, E560 GENBANK:XP_005504328
MER0574067 Condylura cristata 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_004685846
MER0572314 Corvus brachyrhynchos 639 365-614 H443, H533, H546 D463, D474, H537, E568, E582 GENBANK:XP_008639363
MER0668662 Corvus cornix 395 133-300 missing, H214, H227 D144, D155, H218, E249, E263 GENBANK:XP_010401624
MER0483253 Cricetulus griseus 652 352-581 H408, H498, H511 D428, D439, H502, E533, E547 GENBANK:XP_003499033
MER0486010 Cricetulus griseus 585 352-577 H430, H517, H530 D450, D461, H521, E552, E566 GENBANK:XP_007624610
MER0665060 Cuculus canorus 714 432-681 H508, H598, H611 D528, D539, H602, E633, E647 GENBANK:XP_009560611
MER0568245 Cynoglossus semilaevis 680 353-604 H431, H521, H534 D451, D462, H525, E556, E570 GENBANK:XP_008324639
MER0036101 Danio rerio 702 378-629 H456, H546, H559 D476, D487, H550, E581, E595 GENBANK:NP_957326
MER0605811 Dasypus novemcinctus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_004465717
MER0599566 Echinops telfairi 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_004713130
MER0664457 Egretta garzetta 316 170-213 missing, H187, H200 missing, missing, H191, missing, missing GENBANK:XP_009634004
MER0564569 Elephantulus edwardii 671 349-600 H427, H517, H530 D447, D458, H521, E552, E566 GENBANK:XP_006881847
MER0564276 Eptesicus fuscus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_008152124
MER0098413 Equus caballus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_001491837
MER0561468 Equus przewalskii 92 13-92 H91, missing, missing missing, missing, missing, missing, missing GENBANK:XP_008510356
MER0661907 Esox lucius 673 350-599 H427, H517, H530 D447, D458, H521, E552, E566 GENBANK:XP_010866007
MER0560009 Falco cherrug 683 370-619 H448, H538, H551 D468, D479, H542, E573, E587 GENBANK:XP_005435873
MER0546147 Falco peregrinus 702 374-623 H452, H542, H555 D472, D483, H546, E577, E591 GENBANK:XP_005236835
MER0610424 Felis catus 675 353-604 H431, H521, H534 D451, D462, H525, E556, E570 UNIPROT:M3W8X1
MER0610424 Felis catus 675 353-604 H431, H521, H534 D451, D462, H525, E556, E570 UNIPROT:M3W8X1
MER0569567 Ficedula albicollis 537 213-464 H289, H379, H392 D309, D320, H383, E414, E428 GENBANK:XP_005046274
MER0657483 Fukomys damarensis 723 504-652 missing, H569, H582 missing, D510, H573, E604, E618 GENBANK:XP_010606315
MER0657484 Fukomys damarensis 747 425-676 H503, H593, H606 D523, D534, H597, E628, E642 GENBANK:XP_010606314
MER0557908 Galeopterus variegatus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_008570614
MER0481706 Gallus gallus 681 351-605 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_420139
MER0606568 Gallus gallus 802 408-511 H486, missing, missing D506, missing, missing, missing, missing GENBANK:XP_004940629
MER0559686 Geospiza fortis 449 190-376 H205, H295, H308 D225, D236, H299, E330, E344 GENBANK:XP_005428860
MER0609732 Gorilla gorilla 644 334-516 H412, H502, H515 D432, D443, H506, missing, missing GENBANK:XP_004064902
MER0651608 Haliaeetus leucocephalus 663 339-588 H417, H507, H520 D437, D448, H511, E542, E556 GENBANK:XP_010565419
MER0482984 Heterocephalus glaber 777 433-706 H511, H623, H636 R513, D518, H627, E658, E672 UNIPROT:G5AU68
MER0482984 Heterocephalus glaber 777 433-706 H511, H623, H636 R513, D518, H627, E658, E672 UNIPROT:G5AU68
MER0584921 Heterocephalus glaber 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_004860094
MER0004498 Homo sapiens 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:AAB32972
MER0004498 Homo sapiens 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:AAB32972
MER0612313 Ictidomys tridecemlineatus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:I3MB87
MER0612313 Ictidomys tridecemlineatus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:I3MB87
MER0483172 Ixodes scapularis 153 7-149 H84, missing, missing D104, D115, missing, missing, missing UNIPROT:B7P3P7
MER0483172 Ixodes scapularis 153 7-149 H84, missing, missing D104, D115, missing, missing, missing UNIPROT:B7P3P7
MER0548122 Jaculus jaculus 674 354-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_004654010
MER0649658 Larimichthys crocea 672 350-599 H427, H517, H530 D447, D458, H521, E552, E566 GENBANK:XP_010741361
MER0554150 Lepisosteus oculatus 752 380-630 H458, H548, H561 D478, D489, H552, E583, E597 GENBANK:XP_006633084
MER0552296 Leptonychotes weddellii 332 26-261 H88, H178, H191 D108, D119, H182, E213, E227 GENBANK:XP_006727412
MER0548597 Lipotes vexillifer 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_007450541
MER0408001 Macaca fascicularis 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:G7Q3N2
MER0408001 Macaca fascicularis 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:G7Q3N2
MER0189868 Macaca mulatta 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:G7NRD8
MER0189868 Macaca mulatta 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:G7NRD8
MER0647360 Manacus vitellinus 481 280-418 missing, H332, H237, H250, H345 missing, missing, H241, H336, E367, missing, E381, missing GENBANK:XP_008919064
MER0647361 Manacus vitellinus 481 194-251 missing, H237, H332, H250, H345 missing, missing, H241, H336, E367, missing, E381, missing GENBANK:XP_008919064
MER0645864 Mandrillus leucophaeus 675 372-604 H431, H521, H534 D451, D462, H525, E556, E570 GENBANK:XP_011844237
MER0542131 Maylandia zebra 673 350-600 H427, H517, H530 D447, D458, H521, E552, E566 GENBANK:XP_004545801
MER0481667 Meleagris gallopavo 658 335-582 H411, H501, H514 D431, D442, H505, E536, E550 GENBANK:XP_003208351
MER0540584 Melopsittacus undulatus 622 296-545 H374, H464, H477 D394, D405, H468, E499, E513 GENBANK:XP_005143653
MER0544337 Mesocricetus auratus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_005076904
MER0538426 Microtus ochrogaster 671 351-600 H427, H517, H530 D447, D458, H521, E552, E566 GENBANK:XP_005358463
MER0483170 Moniliophthora perniciosa 155 3-155 H55, H145, missing D75, D86, H149, missing, missing UNIPROT:E2LDC1
MER0483170 Moniliophthora perniciosa 155 3-155 H55, H145, missing D75, D86, H149, missing, missing UNIPROT:E2LDC1
MER0189871 Monodelphis domestica 729 407-657 H485, H575, H588 D505, D516, H579, E610, E624 UNIPROT:F7EVW3
MER0189871 Monodelphis domestica 729 407-657 H485, H575, H588 D505, D516, H579, E610, E624 UNIPROT:F7EVW3
MER0015989 Mus musculus 673 352-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:Q3TPA9
MER0015989 Mus musculus 673 352-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:Q3TPA9
MER0482745 Mustela putorius 85 1-85 H45, missing, missing D65, D76, missing, missing, missing UNIPROT:G9KY72
MER0482745 Mustela putorius 85 1-85 H45, missing, missing D65, D76, missing, missing, missing UNIPROT:G9KY72
MER0485055 Mustela putorius 137 1-66 missing, missing, missing missing, missing, missing, E18, E32 UNIPROT:G9KY73
MER0485055 Mustela putorius 137 1-66 missing, missing, missing missing, missing, missing, E18, E32 UNIPROT:G9KY73
MER0566587 Myotis brandtii 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:S7N3Y6
MER0566587 Myotis brandtii 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:S7N3Y6
MER0613856 Myotis davidii 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_006754706
MER0481637 Naegleria gruberi 675 316-568 H393, H483, H496 D413, D424, H487, E518, E532 GENBANK:XP_002678353
MER0639116 Nannospalax galili 674 354-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_008824931
MER0535977 Neolamprologus brichardi 710 387-637 H464, H554, H567 D484, D495, H558, E589, E603 GENBANK:XP_006782007
MER0636224 Nipponia nippon 597 233-487 H311, H401, H414 D331, D342, H405, E436, E450 GENBANK:XP_009463296
MER0635160 Notothenia coriiceps 718 395-644 H472, H562, H575 D492, D503, H566, E597, E611 GENBANK:XP_010769955
MER0534207 Ochotona princeps 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_004587842
MER0532574 Octodon degus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_004634571
MER0531019 Odobenus rosmarus 675 353-604 H431, H521, H534 D451, D462, H525, E556, E570 GENBANK:XP_004400281
MER0530010 Orcinus orca 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_004280579
MER0481685 Oreochromis niloticus 673 350-599 H427, H517, H530 D447, D458, H521, E552, E566 UNIPROT:I3J311
MER0481685 Oreochromis niloticus 673 350-599 H427, H517, H530 D447, D458, H521, E552, E566 UNIPROT:I3J311
MER0098028 Ornithorhynchus anatinus 593 353-593 H431, H533, H546 D451, D462, H537, E568, E582 GENBANK:XP_007661402
MER0528745 Orycteropus afer 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_007947956
MER0110376 Oryctolagus cuniculus 672 350-601 H428, H518, H531 D448, D459, H522, E553, E567 GENBANK:XP_002720422
MER0594774 Otolemur garnettii 674 353-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:H0WGD0
MER0594774 Otolemur garnettii 674 353-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:H0WGD0
MER0619706 Ovis aries 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 UNIPROT:W5Q009
MER0619706 Ovis aries 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 UNIPROT:W5Q009
MER0593887 Pan paniscus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_003818976
MER0189920 Pan troglodytes 675 367-604 H431, H521, H534 D451, D462, H525, E556, E570 UNIPROT:K7BEH8
MER0189920 Pan troglodytes 675 367-604 H431, H521, H534 D451, D462, H525, E556, E570 UNIPROT:K7BEH8
MER0518757 Panthera tigris 675 353-604 H431, H521, H534 D451, D462, H525, E556, E570 GENBANK:XP_007085499
MER0517903 Pantholops hodgsonii 677 351-602 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_005967026
MER0526390 Papio anubis 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:A0A096NC77
MER0526390 Papio anubis 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 UNIPROT:A0A096NC77
MER0524651 Pelodiscus sinensis 446 214-386 H236, H326, H339 D256, D267, H330, E361, E375 GENBANK:XP_006125569
MER0520919 Physeter catodon 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_007103095
MER0629174 Picoides pubescens 634 303-557 H381, H471, H484 D401, D412, H475, E506, E520 GENBANK:XP_009906552
MER0521351 Poecilia formosa 672 350-599 H427, H517, H530 D447, D458, H521, E552, E566 UNIPROT:A0A087YGK4
MER0521351 Poecilia formosa 672 350-599 H427, H517, H530 D447, D458, H521, E552, E566 UNIPROT:A0A087YGK4
MER0514103 Poecilia reticulata 672 350-599 H427, H517, H530 D447, D458, H521, E552, E566 GENBANK:XP_008418870
MER0481644 Pongo abelii 679 357-608 H435, H525, H538 D455, D466, H529, E560, E574 GENBANK:XP_002832146
MER0515507 Pteropus alecto 671 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_006918860
MER0598306 Pteropus vampyrus 671 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_011382502
MER0440743 Python bivittatus 681 354-607 H432, H522, H535 D452, D463, H526, E557, E571 GENBANK:XP_007422705
MER0015988 Rattus norvegicus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:AAH74017
MER0015988 Rattus norvegicus 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:AAH74017
MER0554162 Rhinopithecus roxellana 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_010353091
MER0512328 Saimiri boliviensis 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_003931163
MER0621820 Sarcophilus harrisii 666 341-591 H419, H509, H522 D439, D450, H513, E544, E558 GENBANK:XP_003774827
MER0544253 Serinus canaria 731 409-658 H487, H577, H590 D507, D518, H581, E612, E626 GENBANK:XP_009088719
MER0597432 Sorex araneus 664 342-593 H420, H510, H523 D440, D451, H514, E545, E559 GENBANK:XP_004606473
MER0519822 Struthio camelus 681 351-606 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_009671350
MER0002039 Sus scrofa 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:AAB34314
MER0002039 Sus scrofa 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:AAB34314
MER0561623 Taeniopygia guttata 657 351-600 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_004177303
MER0596010 Tarsius syrichta 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_008053545
MER0080186 Tetraodon nigroviridis 631 312-565 H392, H482, H495 D412, D423, H486, E517, E531 UNIPROT:Q4SWQ1
MER0080186 Tetraodon nigroviridis 631 312-565 H392, H482, H495 D412, D423, H486, E517, E531 UNIPROT:Q4SWQ1
MER0481751 Tinamus guttatus 593 314-518 H362, H432, H445 D364, D373, H436, E467, E481 GENBANK:XP_010220143
MER0477885 Trichechus manatus 673 352-602 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_004379663
MER0598163 Tupaia chinensis 674 352-603 H430, H520, H533 D450, D461, H524, E555, E569 GENBANK:XP_006165912
MER0622909 Tursiops truncatus 575 329-504 D331, H421, H434 D351, D362, H425, E456, E470 GENBANK:XP_004319299
MER0270665 Ursus maritimus 690 369-619 H446, H536, H549 D466, D477, H540, E571, E585 GENBANK:XP_008694017
MER0617107 Vicugna pacos 673 351-602 H429, H519, H532 D449, D460, H523, E554, E568 GENBANK:XP_006204058
MER0079264 Xenopus laevis 701 376-628 H452, H542, H555 D472, D483, H546, E577, E591 UNIPROT:Q6NRQ8
MER0079264 Xenopus laevis 701 376-628 H452, H542, H555 D472, D483, H546, E577, E591 UNIPROT:Q6NRQ8
MER0079601 Xenopus laevis 691 366-617 H442, H532, H545 D462, D473, H536, E567, E581 UNIPROT:Q66KF4
MER0079601 Xenopus laevis 691 366-617 H442, H532, H545 D462, D473, H536, E567, E581 UNIPROT:Q66KF4
MER0077995 Xenopus tropicalis 687 360-613 H438, H528, H541 D458, D469, H532, E563, E577 GENBANK:XP_002940335
MER0453120 Xiphophorus maculatus 719 397-646 H474, H564, H577 D494, D505, H568, E599, E613 GENBANK:XP_005799633
MER0449019 Zonotrichia albicollis 811 272-435 missing, H355, H368 D285, D296, H359, E390, E404 GENBANK:XP_005494049

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use