$VAR1 = undef;

Summary for peptidase M24.005: aminopeptidase P2

Names
MEROPS Name	aminopeptidase P2
Other names	aminopeptidase P (eukaryote membrane-bound type), aminoacylproline aminopeptidase, membrane aminopeptidase P, microsomal proline aminopeptidase, X-Pro aminopeptidase (eukaryote), XPNPEP2 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan MG >> Subclan (none) >> Family M24 >> Subfamily B >> M24.005
Holotype	aminopeptidase P2 (Sus scrofa), Uniprot accession Q95333 (peptidase unit: 351-602), MERNUM MER0002039
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00240
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.9
Enzymology	BRENDA database
Proteolytic events	CutDB database (2 cleavages)
Activity status	human: active (Simmons, 2004) mouse: active (by similarity) (Ersahin et al., 2003)
Physiology	Proposed to have a role in degration of bradykinin and neuropeptide Y.
Knockout	A candidate gene for premature ovarian failure (Prueitt et al., 2000).
Pathways	KEGG	Protein digestion and absorption
Other databases	TREEFAM	http://www.treefam.org/family/TF314183
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/grP/P/-/- (based on 13 cleavages)

Specificity matrix

Amino acid	P1	P1'	P2'	P3'	P4'
Gly	3	0	0	3	0
Pro	0	13	10	0	1
Ala	0	0	0	0	0
Val	0	0	0	0	0
Leu	0	0	0	0	0
Ile	0	0	0	0	0
Met	0	0	0	0	0
Phe	0	0	0	0	2
Tyr	1	0	0	0	0
Trp	0	0	0	0	0
Ser	0	0	1	0	0
Thr	0	0	0	0	0
Cys	0	0	0	0	0
Asn	0	0	0	0	0
Gln	0	0	0	0	0
Asp	0	0	0	0	0
Glu	0	0	0	0	0
Lys	0	0	0	1	0
Arg	3	0	0	0	0
His	0	0	0	0	0