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Substrates for peptidase M24.002: methionyl aminopeptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
3-isopropylmalate dehydrogenase P50455 1-337 Met1+Gly-peptide P NT - - - Met Gly Phe Thr Val Yoda et al., 1995
30S ribosomal protein S11P P10788 1-129 Met1+Ser-peptide P NT - - - Met Ser Glu Glu Thr Kimura et al., 1988
30S ribosomal protein S15P/S13e P05762 1-156 Met1+Ala-peptide P NT - - - Met Ala Arg Met His
30S ribosomal protein S17e Q5V5R5 1-63 Met1+Ala-peptide P NT - - - Met Ala Ile Lys Pro Engemann et al., 1995
30S ribosomal protein S17P P12741 1-112 Met1+Ala-peptide P NT - - - Met Ala Leu Gly Leu Kimura & Kimura, 1987
30S ribosomal protein S19e P19952 1-153 Met1+Ala-peptide P NT - - - Met Ala Thr Leu Tyr
30S ribosomal protein S19P P20284 1-140 Met1+Ser-peptide P NT - - - Met Ser Ser Glu Tyr Kimura et al., 1989
30S ribosomal protein S27ae Q06125 1-44 Met1+Pro-peptide P NT - - - Met Pro His Asn Glu
30S ribosomal protein S6e P21509 1-129 Met1+Ala-peptide P NT - - - Met Ala Glu Phe Thr Kimura et al., 1989
30S ribosomal protein S7P P32552 1-206 Met1+Ser-peptide P NT - - - Met Ser Ala Glu Asp Klussmann et al., 1993
30S ribosomal protein S8P P12742 1-130 Met1+Thr-peptide P NT - - - Met Thr Gly Asn Asp Kimura & Kimura, 1987
30S ribosomal protein S9P P05763 1-132 Met1+Val-peptide P NT - - - Met Val Thr Asn Thr
5,10-methenyltetrahydromethanopterin hydrogenase Q02394 1-358 Met1+Val-peptide P NT - - - Met Val Glu Ile Asn Ma et al., 1991
5,10-methylenetetrahydromethanopterin reductase Q8TXY4 1-349 Met1+Ala-peptide P NT - - - Met Ala Glu Val Ser Ma et al., 1991
50S ribosomal protein L11P P35025 1-170 Met1+Pro-peptide P NT - - - Met Pro Thr Lys Thr Casiano & Traut, 1991
50S ribosomal protein L11P P14122 1-162 Met1+Ala-peptide P NT - - - Met Ala Gly Thr Ile Walsh et al., 1988
50S ribosomal protein L11P P05969 1-163 Met1+Ala-peptide P NT - - - Met Ala Glu Thr Ile Matheson et al., 1984
50S ribosomal protein L15e P60618 1-196 Met1+Ala-peptide P NT - - - Met Ala Arg Ser Ala Walsh et al., 1988
50S ribosomal protein L15P P05971 1-153 Met1+Thr-peptide P NT - - - Met Thr Asp Lys Lys Matheson et al., 1984
50S ribosomal protein L15P P12737 1-165 Met1+Thr-peptide P NT - - - Met Thr Ser Lys Lys Walsh et al., 1988
50S ribosomal protein L18e P12733 1-116 Met1+Ser-peptide P NT - - - Met Ser Lys Thr Asn Walsh et al., 1988
50S ribosomal protein L18P P14123 1-187 Met1+Ala-peptide P NT - - - Met Ala Thr Gly Pro Walsh et al., 1988
50S ribosomal protein L18P P50562 1-183 Met1+Ala-peptide P NT - - - Met Ala Thr Gly Pro McDougall & Wittmann-Liebold, 1994
50S ribosomal protein L19e P14119 1-149 Met1+Thr-peptide P NT - - - Met Thr Asp Leu Ser Hatakeyama et al., 1989
50S ribosomal protein L1P P13575 1-212 Met1+Ala-peptide P NT - - - Met Ala Asp Asn Asp Matheson et al., 1984
50S ribosomal protein L1P P12738 1-212 Met1+Ala-peptide P NT - - - Met Ala Asp Gln Glu Walsh et al., 1988
50S ribosomal protein L21e P12734 1-96 Met1+Pro-peptide P NT - - - Met Pro Ser Ser Asn Hatakeyama & Kimura, 1988
50S ribosomal protein L21e Q9HQG8 1-99 Met1+Pro-peptide P NT - - - Met Pro Asn Ser Asn Matheson et al., 1984
50S ribosomal protein L22P P10970 1-155 Met1+Gly-peptide P NT - - - Met Gly Ile Ser Tyr Walsh et al., 1988
50S ribosomal protein L22P P15008 1-156 Met1+Gly-peptide P NT - - - Met Gly Ile Ser Tyr Matheson et al., 1984
50S ribosomal protein L23P Q06842 1-84 Met1+Ser-peptide P NT - - - Met Ser Ser Ile Ile Matheson et al., 1984
50S ribosomal protein L23P P12732 1-85 Met1+Ser-peptide P NT - - - Met Ser Trp Asp Val Walsh et al., 1988
50S ribosomal protein L24e P14116 1-67 Met1+Pro-peptide P NT - - - Met Pro Arg Thr Arg Hatakeyama et al., 1989
50S ribosomal protein L24P P10972 1-120 Met1+Ser-peptide P NT - - - Met Ser Lys Gln Pro Walsh et al., 1988
50S ribosomal protein L29P P10971 1-71 Met1+Thr-peptide P NT - - - Met Thr Val Leu His Hatakeyama et al., 1988
50S ribosomal protein L31e P18138 1-92 Met1+Ser-peptide P NT - - - Met Ser Ala Ser Asp Hatakeyama & Hatakeyama, 1990
50S ribosomal protein L32e Q9HPB7 1-239 Met1+Ser-peptide P NT - - - Met Ser Asp Glu Asn Matheson et al., 1984
50S ribosomal protein L32e P12736 1-241 Met1+Ala-peptide P NT - - - Met Ala Asp Asn Glu Walsh et al., 1988
50S ribosomal protein L37e P32410 1-57 Met1+Thr-peptide P NT - - - Met Thr Gly Ala Gly Bergmann & Wittmann-Liebold, 1993
50S ribosomal protein L39e P13005 1-51 Met1+Ser-peptide P NT - - - Met Ser Lys His Lys Ramirez et al., 1989
50S ribosomal protein L39e P22452 1-50 Met1+Gly-peptide P NT - - - Met Gly Lys Lys Ser Bergmann & Arndt, 1990
50S ribosomal protein L5P P14124 1-177 Met1+Ser-peptide P NT - - - Met Ser Ser Glu Ser Walsh et al., 1988
50S ribosomal protein L5P P50558 1-175 Met1+Ser-peptide P NT - - - Met Ser Glu Thr Asp McDougall & Wittmann-Liebold, 1994
50S ribosomal protein L6P P14135 1-178 Met1+Pro-peptide P NT - - - Met Pro Arg Val Glu Walsh et al., 1988
50S ribosomal protein L6P Q9HPB8 1-178 Met1+Ala-peptide P NT - - - Met Ala Arg Val Glu Matheson et al., 1984
50S ribosomal protein L7Ae P12743 1-120 Met1+Pro-peptide P NT - - - Met Pro Val Tyr Val Kimura et al., 1987
50S ribosomal protein LX P14125 1-56 Met1+Ser-peptide P NT - - - Met Ser Thr Tyr Thr Hatakeyama et al., 1989
50S ribosomal protein LX P38613 1-86 Met1+Ala-peptide P NT - - - Met Ala Glu Val Lys Ramirez et al., 1991
acetyl-CoA decarbonylase/synthase complex subunit alpha 1 Q49161 1-806 Met1+Ser-peptide P NT - - - Met Ser Lys Leu Thr Eggen et al., 1996
acetyl-CoA decarbonylase/synthase complex subunit alpha 1 Q08368 1-806 Met1+Ser-peptide P NT - - - Met Ser Lys Leu Thr Sowers et al., 1993
acetyl-CoA decarbonylase/synthase complex subunit alpha 2 Q49163 1-807 Met1+Ser-peptide P NT - - - Met Ser Lys Leu Thr Eggen et al., 1996
acetyl-CoA decarbonylase/synthase complex subunit beta O29868 1-524 Met1+Val-peptide P NT - - - Met Val Glu Arg Lys Dai et al., 1998
acetyl-CoA decarbonylase/synthase complex subunit beta 1 P72021 1-469 Met1+Ala-peptide P NT - - - Met Ala Glu Phe Pro Maupin-Furlow & Ferry, 1996
acetyl-CoA decarbonylase/synthase complex subunit epsilon 1 P72020 1-170 Met1+Val-peptide P NT - - - Met Val Asp Thr Thr Maupin-Furlow & Ferry, 1996
acetyl-CoA decarbonylase/synthase complex subunit epsilon 2 O30273 1-175 Met1+Ala-peptide P NT - - - Met Ala Lys Ala Leu Dai et al., 1998
ADP-dependent glucokinase Q9V2Z6 1-455 Met1+Pro-peptide P NT - - - Met Pro Thr Trp Glu Kengen et al., 1995
aspartate aminotransferase P14909 1-402 Met1+Val-peptide P NT - - - Met Val Ser Leu Leu Marino et al., 1988
citrate synthase P21553 1-385 Met1+Pro-peptide P NT - - - Met Pro Glu Thr Glu
coB--CoM heterodisulfide reductase iron-sulfur subunit A Q50756 1-659 Met1+Ala-peptide P NT - - - Met Ala Glu Glu Lys Setzke et al., 1994
coB--CoM heterodisulfide reductase iron-sulfur subunit C Q50754 1-185 Met1+Thr-peptide P NT - - - Met Thr Leu Leu Gln Setzke et al., 1994
coB--CoM heterodisulfide reductase iron-sulfur subunit D P96797 1-409 Met1+Ala-peptide P NT - - - Met Ala Lys Arg Thr Heiden et al., 1994
coenzyme F420 hydrogenase subunit alpha P19496 1-405 Met1+Ser-peptide P NT - - - Met Ser Glu Arg Ile Fox et al., 1987
coenzyme F420 hydrogenase subunit alpha P80489 1-456 Met1+Thr-peptide P NT - - - Met Thr Lys Val Val Michel et al., 1995
coenzyme F420 hydrogenase subunit beta P19499 1-281 Met1+Val-peptide P NT - - - Met Val Leu Gly Thr Fox et al., 1987
coenzyme F420 hydrogenase subunit gamma P19498 1-236 Met1+Ala-peptide P NT - - - Met Ala Glu Glu Asn Fox et al., 1987
coenzyme F420 hydrogenase subunit gamma P80491 1-259 Met1+Thr-peptide P NT - - - Met Thr Asn Lys Ile Michel et al., 1995
cyclic 2,3-diphosphoglycerate synthetase O93732 1-460 Met1+Gly-peptide P NT - - - Met Gly Glu Thr Lys Matussek et al., 1998
dihydrolipoyl dehydrogenase Q04829 1-475 Met1+Val-peptide P NT - - - Met Val Val Gly Asp Vettakkorumakankav et al., 1992
dimethylamine corrinoid protein O93657 1-213 Met1+Ser-peptide P NT - - - Met Ser Lys Glu Glu Ferguson et al., 2000
DNA-binding protein 7a P61991 1-64 Met1+Ala-peptide P NT - - - Met Ala Thr Val Lys Faraone-Mennella & Farina, 1995
DNA-binding protein 7b P13123 1-66 Met1+Val-peptide P NT - - - Met Val Lys Val Lys Choli et al., 1988
DNA-binding protein 7d P39476 1-64 Met1+Ala-peptide P NT - - - Met Ala Thr Val Lys Guagliardi et al., 1992
DNA-binding protein 7e P13125 1-65 Met1+Ala-peptide P NT - - - Met Ala Lys Val Arg Choli et al., 1988
elongation factor 1-alpha P16018 1-421 Met1+Ser-peptide P NT - - - Met Ser Asp Glu Gln Guinet et al., 1988
elongation factor 1-beta Q64214 1-91 Met1+Thr-peptide P NT - - - Met Thr Asp Val Leu Arcari et al., 1995
elongation factor 2 P30925 1-736 Met1+Pro-peptide P NT - - - Met Pro Arg Tyr Lys Raimo et al., 1992
elongation factor 2 P23112 1-737 Met1+Pro-peptide P NT - - - Met Pro Arg Tyr Lys Schroeder & Klink, 1991
Elongation factor 2 P13639 1-858 Met1+Val-peptide P MS - - - Met Val Asn Phe Thr Warder et al., 2008
F420-dependent methylenetetrahydromethanopterin dehydrogenase O29544 1-273 Met1+Val-peptide P NT - - - Met Val Val Lys Val Schworer et al., 1993
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 1-283 Met1+Thr-peptide P NT - - - Met Thr Val Ala Lys Klein et al., 1993
ferredoxin P00216 1-129 Met1+Pro-peptide P NT - - - Met Pro Thr Val Glu Hase et al., 1978
ferredoxin-1 P00217 1-129 Met1+Pro-peptide P NT - - - Met Pro Thr Val Glu Hase et al., 1980
glucose 1-dehydrogenase P13203 1-361 Met1+Thr-peptide P NT - - - Met Thr Glu Gln Lys Smith et al., 1989
glutamate dehydrogenase O59650 1-421 Met1+Val-peptide P NT - - - Met Val Glu Ile Asp Rahman et al., 1998
glutamate dehydrogenase Q56304 1-419 Met1+Val-peptide P NT - - - Met Val Glu Gln Asp Ma et al., 1994
glutamate dehydrogenase 2 P80053 1-420 Met1+Met-peptide P NT - - - Met Met Glu Glu Val Maras et al., 1992
glutathione S-transferase class-mu 26 kDa isozyme P08515 1-218 Met1+Ser-peptide P - - - Met Ser Pro Ile Leu Chen et al., 2002
Glutathione S-transferase class-mu 26 kDa isozyme (Ser2Ala mutant) Met1+Ala-peptide P - - - Met Ala Pro Ile Leu Chen et al., 2002
Glutathione S-transferase class-mu 26 kDa isozyme (Ser2Pro mutant) peptide-Met1+Pro-peptide P - - - Met Pro Pro Ile Leu Chen et al., 2002
Glutathione S-transferase class-mu 26 kDa isozyme (Ser2Val mutant) Met1+Val-peptide P - - - Met Val Pro Ile Leu Chen et al., 2002
Glyceraldehyde-3-phosphate dehydrogenase P04406 1-335 Met1+Gly-peptide P MS - - - Met Gly Lys Val Lys Warder et al., 2008
malate dehydrogenase P11386 1-306 Met1+Val-peptide P NT - - - Met Val Lys Val Ala Gorisch & Jany, 1989
Met-Pro-pNA Met+Pro-pNA S - - - Met Pro pNA - - Zhou et al., 2000
methenyltetrahydromethanopterin cyclohydrolase P51616 1-320 Met1+Val-peptide P NT - - - Met Val Ser Val Asn Vaupel et al., 1996
methyl-coenzyme M reductase I subunit beta O27236 1-443 Met1+Ala-peptide P NT - - - Met Ala Lys Phe Glu Rospert et al., 1990
methyl-coenzyme M reductase I subunit gamma O27233 1-249 Met1+Ala-peptide P NT - - - Met Ala Gln Tyr Tyr Rospert et al., 1990
methyl-coenzyme M reductase II subunit beta P21111 1-443 Met1+Pro-peptide P NT - - - Met Pro Met Tyr Glu Rospert et al., 1990
methyl-coenzyme M reductase II subunit gamma P58816 1-15 Met1+Ser-peptide P NT - - - Met Ser Tyr Lys Ala Rospert et al., 1990
methyl-coenzyme M reductase II subunit gamma P21112 1-265 Met1+Thr-peptide P NT - - - Met Thr Tyr Lys Ala Rospert et al., 1990
methyl-coenzyme M reductase subunit alpha O27232 1-550 Met1+Ala-peptide P NT - - - Met Ala Asp Lys Leu Rospert et al., 1990
methylcobamide:CoM methyltransferase mtbA O30640 1-339 Met1+Ala-peptide P NT - - - Met Ala Glu Tyr Thr Burke & Krzycki, 1995
monomethylamine corrinoid protein 1 O30641 1-217 Met1+Ala-peptide P NT - - - Met Ala Asn Gln Glu Burke et al., 1998
monomethylamine methyltransferase mtmB1 O30642 1-458 Met1+Thr-peptide P NT - - - Met Thr Phe Arg Lys James et al., 2001
ornithine carbamoyltransferase Q51742 1-315 Met1+Val-peptide P NT - - - Met Val Val Ser Leu Legrain et al., 1997
Peptidyl-prolyl cis-trans isomerase A P62937 1-165 Met1+Val-peptide P MS - - - Met Val Asn Pro Thr Warder et al., 2008
phosphate acetyltransferase P38503 1-333 Met1+Val-peptide P NT - - - Met Val Thr Phe Leu Latimer & Ferry, 1993
phosphoenolpyruvate synthase P42850 1-817 Met1+Ala-peptide P NT - - - Met Ala Tyr Arg Phe Hutchins et al., 2001
protein cysO Q9YBL2 1-389 Met1+Ala-peptide P NT - - - Met Ala Leu Ala Asp Mino & Ishikawa, 2003
putative thymidylate synthase P80305 1-223 Met1+Ala-peptide P NT - - - Met Ala Tyr Glu Ile Krone et al., 1994
pyruvate synthase subunit porB Q51805 1-331 Met1+Ala-peptide P NT - - - Met Ala Val Arg Lys Kletzin & Adams, 1996
pyruvate synthase subunit porB P80522 1-296 Met1+Ser-peptide P NT - - - Met Ser Lys Thr Ala Bock et al., 1996
pyruvate synthase subunit porD Q51803 1-105 Met1+Ala-peptide P NT - - - Met Ala Glu Ser Pro Kletzin & Adams, 1996
replication factor C large subunit Q9V2G3 1-479 Met1+Pro-peptide P NT - - - Met Pro Glu Val Pro Henneke et al., 2002
repressor-like protein SSo7c3 P81551 1-52 Met1+Pro-peptide P NT - - - Met Pro Val Glu Glu Oppermann et al., 1998
repressor-like protein SSo7c4 P81552 1-56 Met1+Ala-peptide P NT - - - Met Ala Val Glu Glu Oppermann et al., 1998
ribulose bisphosphate carboxylase O93627 1-444 Met1+Val-peptide P NT - - - Met Val Glu Lys Phe Maeda et al., 1999
RNA-binding protein AU-1 Q8U4Q7 1-469 Met1+Ser-peptide P NT - - - Met Ser Thr Glu Ser Kanai et al., 2003
rubredoxin P24297 1-54 Met1+Ala-peptide P NT - - - Met Ala Lys Trp Val Blake et al., 1991
SH3 domain-binding glutamic acid-rich-like protein O75368 1-114 Met1+Val-peptide P MS - - - Met Val Ile Arg Val Warder et al., 2008
sulfite reductase, dissimilatory-type subunit alpha Q59109 1-418 Met1+Ser-peptide P NT - - - Met Ser Glu Thr Pro Dahl et al., 1993
sulfur oxygenase/reductase P29082 1-309 Met1+Pro-peptide P NT - - - Met Pro Lys Pro Tyr Kletzin 1992
sulredoxin Q9HH83 1-109 Met1+Val-peptide P NT - - - Met Val Trp Lys Arg Iwasaki et al., 1995
superoxide dismutase [Fe] P80857 1-211 Met1+Thr-peptide P NT - - - Met Thr Leu Gln Ile Dello et al., 1997
superoxide dismutase [Mn] 1 P09737 1-200 Met1+Ser-peptide P NT - - - Met Ser Glu Tyr Glu May & Dennis, 1987
tetrahydromethanopterin S-methyltransferase subunit B P80655 1-108 Met1+Ser-peptide P NT - - - Met Ser Ile Val Arg Lienard et al., 1996
tetrahydromethanopterin S-methyltransferase subunit F P80654 1-72 Met1+Ala-peptide P NT - - - Met Ala Glu Glu His Lienard et al., 1996
tetrahydromethanopterin S-methyltransferase subunit G Q50774 1-86 Met1+Ser-peptide P NT - - - Met Ser Glu Glu Glu Harms et al., 1995
Thioredoxin P10599 1-105 Met1+Val-peptide P MS - - - Met Val Lys Gln Ile Warder et al., 2008
trimethylamine corrinoid protein O93659 1-217 Met1+Ala-peptide P NT - - - Met Ala Asn Lys Glu Paul et al., 2000
trimethylamine methyltransferase mttB O93658 1-495 Met1+Ala-peptide P NT - - - Met Ala Lys Asn Asn Paul et al., 2000
triosephosphate isomerase P62003 1-228 Met1+Ala-peptide P NT - - - Met Ala Lys Leu Lys Kohlhoff et al., 1996
uroporphyrinogen-III C-methyltransferase P29564 1-231 Met1+Val-peptide P NT - - - Met Val Val Tyr Leu Blanche et al., 1991
V-type ATP synthase alpha chain Q971B7 1-592 Met1+Val-peptide P NT - - - Met Val Ser Glu Gly Denda et al., 1988
zinc-containing ferredoxin P00218 1-143 Met1+Val-peptide P NT - - - Met Val Lys Leu Glu Iwasaki et al., 1997
zinc-containing ferredoxin-1 P55907 1-104 Met1+Gly-peptide P NT - - - Met Gly Ile Asp Pro Iwasaki et al., 1995

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