Literature for peptidase M24.002: methionyl aminopeptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Osana,S., Tsai,C.T., Suzuki,N., Murayama,K., Kaneko,M., Hata,K., Takada,H., Kano,Y. and Nagatomi,R. Inhibition of methionine aminopeptidase in C2C12 myoblasts disrupts cell integrity via increasing endoplasmic reticulum stress Biochim Biophys Acta Mol Cell Res (2025) 1872, 119901-119901. PubMed Europe PubMed DOI K

2024

Cornelius,P., Mayes,B.A., Petersen,J.S., Turnquist,D.J., Dufour,P.J., Dannenberg,A.J., Shanahan,J.M. and Carver,B.J. Pharmacological Characterization of SDX-7320/Evexomostat: a Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-Tumor and Anti-Metastatic Activity Mol Cancer Ther (2024) 23, 595-605. PubMed Europe PubMed DOI I
Friese-Hamim,M., Ortiz Ruiz,M.J., Bogatyrova,O., Keil,M., Rohdich,F., Blume,B., Leuthner,B., Czauderna,F., Hahn,D., Jabs,J., Jaehrling,F., Heinrich,T., Kellner,R., Chan,K., Tong,A.H.Y., Wienke,D., Moffat,J., Blaukat,A. and Zenke,F.T. Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models Mol Cancer Ther (2024) 23, 159-173. PubMed Europe PubMed DOI PMC EPMC I
Klein,M.A., Wild,K., Kisonaite,M. and Sinning,I. Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome Nat Commun (2024) 15, 716-716. PubMed Europe PubMed DOI PMC EPMC
Rubina, Moin,S.T. and Haider,S. Identification of a Cryptic Pocket in Methionine Aminopeptidase-II Using Adaptive Bandit Molecular Dynamics Simulations and Markov State Models ACS Omega (2024) 9, 28534-28545. PubMed Europe PubMed DOI PMC EPMC

2023

Bala,S., Reddi,B. and Addlagatta,A. A single amino acid difference between archaeal and human type 2 methionine aminopeptidases differentiates their affinity towards ovalicin Biochim Biophys Acta Proteins Proteom (2023) 1871, 140881-140881. PubMed Europe PubMed DOI I
Lignet,F., Friese-Hamim,M., Jaehrling,F., El Bawab,S. and Rohdich,F. Preclinical Pharmacokinetics and Translational Pharmacokinetic/Pharmacodynamic Modeling of M8891, a Potent and Reversible Inhibitor of Methionine Aminopeptidase 2 Pharm Res (2023) 40, 3011-3023. PubMed Europe PubMed DOI PMC EPMC I

2022

Shimizu,S., Kawahara,R. and Simizu,S. Methionine aminopeptidase2 is a pivotal regulator of vasculogenic mimicry Oncol Rep (2022) 47 PubMed Europe PubMed DOI PMC EPMC

2021

Albayati,S., Uba,A.I. and Yelekci,K. Potential inhibitors of methionine aminopeptidase type II identified via structure-based pharmacophore modeling Mol Divers (2021) PubMed Europe PubMed DOI
Craig,S.L., Gault,V.A., Flatt,P.R. and Irwin,N. The methionine aminopeptidase 2 inhibitor, TNP-470, enhances the antidiabetic properties of sitagliptin in mice by upregulating xenin Biochem Pharmacol (2021) 183, 114355-114355. PubMed Europe PubMed DOI I
Goya Grocin,A., Kallemeijn,W.W. and Tate,E.W. Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity Trends Pharmacol Sci (2021) 42, 870-882. PubMed Europe PubMed DOI

2020

Esa,R., Steinberg,E., Dror,D., Schwob,O., Khajavi,M., Maoz,M., Kinarty,Y., Inbal,A., Zick,A. and Benny,O. The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis Int J Mol Sci (2020) 21, 5148-5148. PubMed Europe PubMed DOI PMC EPMC
Weako,J., Uba,A.I., Keskin,O., Gursoy,A. and Yelekci,K. Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: structure-based virtual screening, ADMET prediction and molecular dynamics studies Comput Biol Chem (2020) 86, 107244-107244. PubMed Europe PubMed DOI
Wentworth,J.M. and Colman,P.G. The methionine aminopeptidase 2 inhibitor ZGN-1061 improves glucose control and weight in overweight and obese individuals with type 2 diabetes: a randomized, placebo-controlled trial Diabetes Obes Metab (2020) 22, 1215-1219. PubMed Europe PubMed DOI I

2019

Heinrich,T., Seenisamy,J., Blume,B., Bomke,J., Calderini,M., Eckert,U., Friese-Hamim,M., Kohl,R., Lehmann,M., Leuthner,B., Musil,D., Rohdich,F. and Zenke,F.T. Discovery and structure-based optimization of next-generation reversible methionine aminopeptidase-2 (MetAP-2) inhibitors J Med Chem (2019) 62, 5025-5039. PubMed Europe PubMed DOI I
Heinrich,T., Seenisamy,J., Becker,F., Blume,B., Bomke,J., Dietz,M., Eckert,U., Friese-Hamim,M., Gunera,J., Hansen,K., Leuthner,B., Musil,D., Pfalzgraf,J., Rohdich,F., Siegl,C., Spuck,D., Wegener,A. and Zenke,F.T. Identification of methionine aminopeptidase-2 (MetAP-2) inhibitor M8891: a clinical compound for the treatment of cancer J Med Chem (2019) 62, 11119-11134. PubMed Europe PubMed DOI I

2018

Bhat,S.Y., Dey,A. and Qureshi,I.A. Structural and functional highlights of methionine aminopeptidase 2 from Leishmania donovani Int J Biol Macromol (2018) 115, 940-954. PubMed Europe PubMed DOI
Coruh,I., Cevik,O., Yelekci,K., Djikic,T. and Kucukguzel,S.G. Synthesis, anticancer activity, and molecular modeling of etodolac-thioether derivatives as potent methionine aminopeptidase (type II) inhibitors Arch Pharm (Weinheim) (2018) 351, e1700195-e1700195. PubMed Europe PubMed DOI I
Esvaran,V.G., Gupta,T., Nayaka,A.R.N., Sivaprasad,V. and Ponnuvel,K.M. Molecular characterization of Nosema bombycis methionine aminopeptidase 2 (MetAP2) gene and evaluation of anti-microsporidian activity of fumagilin-B in silkworm Bombyx mori 3 Biotech (2018) 8, 386-386. PubMed Europe PubMed DOI PMC EPMC
Lin,M., Zhang,X., Jia,B. and Guan,S. Suppression of glioblastoma growth and angiogenesis through molecular targeting of methionine aminopeptidase-2 J Neurooncol (2018) 136, 243-254. PubMed Europe PubMed DOI K

2017

Heinrich,T., Buchstaller,H.P., Cezanne,B., Rohdich,F., Bomke,J., Friese-Hamim,M., Krier,M., Knochel,T., Musil,D., Leuthner,B. and Zenke,F. Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates Bioorg Med Chem Lett (2017) 27, 551-556. PubMed Europe PubMed DOI I
Kumar,R., Tiwari,K. and Dubey,V.K. Methionine aminopeptidase 2 is a key regulator of apoptotic like cell death in Leishmania donovani Sci Rep (2017) 7, 95-95. PubMed Europe PubMed DOI I

2016

Cheruvallath,Z., Tang,M., McBride,C., Komandla,M., Miura,J., Ton-Nu,T., Erikson,P., Feng,J., Farrell,P., Lawson,J.D., Vanderpool,D., Wu,Y., Dougan,D.R., Plonowski,A., Holub,C. and Larson,C. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 1 Bioorg Med Chem Lett (2016) 26, 2774-2778. PubMed Europe PubMed DOI I
Ehlers,T., Furness,S., Robinson,T.P., Zhong,H.A., Goldsmith,D., Aribser,J. and Bowen,J.P. Methionine aminopeptidase type-2 inhibitors targeting angiogenesis Curr Top Med Chem (2016) 16, 1478-1488. PubMed Europe PubMed V I
McBride,C., Cheruvallath,Z., Komandla,M., Tang,M., Farrell,P., Lawson,J.D., Vanderpool,D., Wu,Y., Dougan,D.R., Plonowski,A., Holub,C. and Larson,C. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 2 Bioorg Med Chem Lett (2016) 26, 2779-2783. PubMed Europe PubMed DOI I
Morgen,M., Jost,C., Malz,M., Janowski,R., Niessing,D., Klein,C.D., Gunkel,N. and Miller,A.K. Spiroepoxytriazoles are fumagillin-like irreversible inhibitors of MetAP2 with potent cellular activity ACS Chem Biol (2016) 11, 1001-1011. PubMed Europe PubMed DOI I
Shimizu,H., Yamagishi,S., Chiba,H. and Ghazizadeh,M. Methionine aminopeptidase 2 as a potential therapeutic target for human non-small-cell lung cancers Adv Clin Exp Med (2016) 25, 117-128. PubMed Europe PubMed T
Weglarz-Tomczak,E., Burda-Grabowska,M., Giurg,M. and Mucha,A. Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: synthesis, inhibitory activity and molecular modeling study Bioorg Med Chem Lett (2016) 26, 5254-5259. PubMed Europe PubMed DOI I

2015

Kang,J.M., Ju,J.W., Kim,J.Y., Ju,H.L., Lee,J., Lee,K.H., Lee,W.J., Sohn,W.M., Kim,T.S. and Na,B.K. Expression and biochemical characterization of a type I methionine aminopeptidase of Plasmodium vivax Protein Expr Purif (2015) 108C, 48-53. PubMed Europe PubMed DOI E
Rosse,G. Pyridinonaphthyridinone inhibitors of type 2 methionine aminopeptidase ACS Med Chem Lett (2015) 6, 622-623. PubMed Europe PubMed DOI PMC EPMC I

2014

Chiu,J., Wong,J.W. and Hogg,P.J. Redox regulation of methionine aminopeptidase 2 activity J Biol Chem (2014) 289, 15035-15043. PubMed Europe PubMed DOI
Joharapurkar,A.A., Dhanesha,N.A. and Jain,M.R. Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity Diabetes Metab Syndr Obes (2014) 7, 73-84. PubMed Europe PubMed DOI PMC EPMC T I

2013

Bonissone,S., Gupta,N., Romine,M., Bradshaw,R.A. and Pevzner,P.A. N-terminal protein processing: a comparative proteogenomic analysis Mol Cell Proteomics (2013) 12, 14-28. PubMed Europe PubMed
Clinkinbeard,T., Ghoshal,S., Craddock,S., Creed Pettigrew,L. and Guttmann,R.P. Calpain cleaves methionine aminopeptidase-2 in a rat model of ischemia/reperfusion Brain Res (2013) 1499, 129-135. PubMed Europe PubMed DOI
[YEAR:1-9-2013]Hughes,T.E., Kim D.D., Marjason,J., Proietto,J., Whitehead J.P. and Vath,J.E. Ascending dose-controlled trial of beloranib, a novel obesity treatment for safety, tolerability, and weight loss in obese women Obesity (Silver Spring, Md.) (1-9-2013) 21, 1782-1788. PubMed Europe PubMed I
Ng,J.Y., Chiu,J., Hogg,P.J. and Wong,J.W. Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2 Biochem Biophys Res Commun (2013) 440, 37-42. PubMed Europe PubMed DOI
Sun,J., Li,M.H., Qian,S.S., Guo,F.J., Dang,X.F., Wang,X.M., Xue,Y.R. and Zhu,H.L. Synthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors Bioorg Med Chem Lett (2013) 23, 2876-2879. PubMed Europe PubMed DOI I

2012

Bradshaw,R.A. and Walker,K.W. Methionyl aminopeptidase type 2 [ISSN:978-0-12-407743-0] (2012) 3, 1501-1506. DOI

2011

Hou,Y.P., Sun,J., Pang,Z.H., Lv,P.C., Li,D.D., Yan,L., Zhang,H.J., Zheng,E.X., Zhao,J. and Zhu,H.L. Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors Bioorg Med Chem (2011) 19, 5948-5954. PubMed Europe PubMed DOI I
Ma,A.C., Fung,T.K., Lin,R.H., Chung,M.I., Yang,D., Ekker,S.C. and Leung,A.Y. Methionine aminopeptidase 2 is required for HSC initiation and proliferation Blood (2011) 118, 5448-5457. PubMed Europe PubMed DOI I
Shapiro,A.B., Gao,N., Thresher,J., Walkup,G.K. and Whiteaker,J. A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase J Biomol Screen (2011) 16, 494-505. PubMed Europe PubMed DOI A

2010

Peng,J., Han,H., Hong,Y., Fu,Z., Liu,J. and Lin,J. Molecular cloning and characterization of a gene encoding methionine aminopeptidase 2 of Schistosoma japonicum Parasitol Res (2010) 107, 939-946. PubMed Europe PubMed DOI
Shahlaei,M., Sabet,R., Ziari,M.B., Moeinifard,B., Fassihi,A. and Karbakhsh,R. QSAR study of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2 using LS-SVM and GRNN based on principal components Eur J Med Chem (2010) 45, 4499-4508. PubMed Europe PubMed DOI I

2009

Alvarado,J.J., Nemkal,A., Sauder,J.M., Russell,M., Akiyoshi,D.E., Shi,W., Almo,S.C. and Weiss,L.M. Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470 Mol Biochem Parasitol (2009) 168, 158-167. PubMed Europe PubMed DOI PMC EPMC S I
Arico-Muendel,C.C., Benjamin,D.R., Caiazzo,T.M., Centrella,P.A., Contonio,B.D., Cook,C.M., Doyle,E.G., Hannig,G., Labenski,M.T., Searle,L.L., Lind,K., Morgan,B.A., Olson,G., Paradise,C.L., Self,C., Skinner,S.R., Sluboski,B., Svendsen,J.L., Thompson,C.D., Westlin,W. and White,K.F. Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2 J Med Chem (2009) 52, 8047-8056. PubMed Europe PubMed DOI I
Chen,X., Xie,S., Bhat,S., Kumar,N., Shapiro,T.A. and Liu,J.O. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo Chem Biol (2009) 16, 193-202. PubMed Europe PubMed DOI I

2008

Lazarus,D.D., Doyle,E.G., Bernier,S.G., Rogers,A.B., Labenski,M.T., Wakefield,J.D., Karp,R.M., Clark,E.J., Lorusso,J., Hoyt,J.G., Thompson,C.D., Hannig,G. and Westlin,W.F. An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis Inflamm Res (2008) 57, 18-27. PubMed Europe PubMed DOI I
Tucker,L.A., Zhang,Q., Sheppard,G.S., Lou,P., Jiang,F., McKeegan,E., Lesniewski,R., Davidsen,S.K., Bell,R.L. and Wang,J. Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation Oncogene (2008) 27, 3967-3976. PubMed Europe PubMed DOI
Warder,S.E., Tucker,L.A., McLoughlin,S.M., Strelitzer,T.J., Meuth,J.L., Zhang,Q., Sheppard,G.S., Richardson,P.L., Lesniewski,R., Davidsen,S.K., Bell,R.L., Rogers,J.C. and Wang,J. Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition J Proteome Res (2008) 7, 4807-4820. PubMed Europe PubMed DOI P

2007

Bainbridge,J., Madden,L., Essex,D., Binks,M., Malhotra,R. and Paleolog,E.M. Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition Arthritis Res Ther (2007) 9, R127-R127. PubMed Europe PubMed DOI PMC EPMC I
Kass,D., Bridges,R.S., Borczuk,A. and Greenberg,S. Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis Am J Respir Cell Mol Biol (2007) 37, 193-201. PubMed Europe PubMed DOI T
Marino,J.P., Jr., Fisher,P.W., Hofmann,G.A., Kirkpatrick,R.B., Janson,C.A., Johnson,R.K., Ma,C., Mattern,M., Meek,T.D., Ryan,M.D., Schulz,C., Smith,W.W., Tew,D.G., Tomazek,T.A., Jr., Veber,D.F., Xiong,W.C., Yamamoto,Y., Yamashita,K., Yang,G. and Thompson,S.K. Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore J Med Chem (2007) 50, 3777-3785. PubMed Europe PubMed DOI S I
Noguchi,S., Komiya,T., Eguchi,H., Shirahata,A., Nikawa,J. and Kawamura,M. Methionine aminopeptidase II: a molecular chaperone for sarcoplasmic reticulum calcium ATPase J Membr Biol (2007) 215, 105-110. PubMed Europe PubMed DOI
Sawanyawisuth,K., Wongkham,C., Pairojkul,C., Saeseow,O.T., Riggins,G.J., Araki,N. and Wongkham,S. Methionine aminopeptidase 2 over-expressed in cholangiocarcinoma: potential for drug target Acta Oncol (2007) 46, 378-385. PubMed Europe PubMed DOI T
Wang,G.T., Mantei,R.A., Kawai,M., Tedrow,J.S., Barnes,D.M., Wang,J., Zhang,Q., Lou,P., Garcia,L.A., Bouska,J., Yates,M., Park,C., Judge,R.A., Lesniewski,R., Sheppard,G.S. and Bell,R.L. Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids Bioorg Med Chem Lett (2007) 17, 2817-2822. PubMed Europe PubMed DOI I

2006

Hu,X., Addlagatta,A., Matthews,B.W. and Liu,J.O. Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases Angew Chem Int Ed Engl (2006) 45, 3772-3775. PubMed Europe PubMed DOI S I
Selvakumar,P., Lakshmikuttyamma,A., Dimmock,J.R. and Sharma,R.K. Methionine aminopeptidase 2 and cancer Biochim Biophys Acta (2006) 1765, 148-154. PubMed Europe PubMed DOI
[YEAR:17-8-2006]Upadhya,R., Zhang,H.S. and Weiss,L.M. System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiae Antimicrob Agents Chemother (17-8-2006) 50, 3389-3395. PubMed Europe PubMed DOI E

2005

Addlagatta,A., Hu,X., Liu,J.O. and Matthews,B.W. Structural basis for the functional differences between type I and type II human methionine aminopeptidases Biochemistry (2005) 44, 14741-14749. PubMed Europe PubMed DOI S I
[YEAR:10-3-2005]Chun,E., Han,C.K., Yoon,J.H., Sim,T.B., Kim,Y.K. and Lee,K.Y. Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model Int J Cancer (10-3-2005) 114, 124-130. PubMed Europe PubMed DOI I
[YEAR:1-3-2005]Vetro,J.A., Dummitt,B., Micka,W.S. and Chang,Y.H. Evidence of a dominant negative mutant of yeast methionine aminopeptidase type 2 in Saccharomyces cerevisiae J Cell Biochem (1-3-2005) 94, 656-668. PubMed Europe PubMed DOI

2004

[YEAR:9-8-2004]Asami,Y., Kakeya,H., Onose,R., Chang,Y.H., Toi,M. and Osada,H. RK-805, an endothelial-cell-growth inhibitor produced by Neosartorya sp., and a docking model with methionine aminopeptidase-2 Tetrahedron (9-8-2004) 60, 7085-7091. DOI I
[YEAR:8-10-2004]Boxem,M., Tsai,C.W., Zhang,Y., Saito,R.M. and Liu,J.O. The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation FEBS Lett (8-10-2004) 576, 245-250. PubMed Europe PubMed DOI K I
Bradshaw,R.A., Yi,E. and Walker,K.W. Methionyl aminopeptidase type II [ISSN:0-12-079610-4] (2004) 2, 917-922. V
[YEAR:5-3-2004]Brdlik,C.M. and Crews,C.M. A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases J Biol Chem (5-3-2004) 279, 9475-9480. PubMed Europe PubMed DOI PMC EPMC I
Giglione,C., Boularot,A. and Meinnel,T. Protein N-terminal methionine excision Cell Mol Life Sci (2004) 61, 1455-1474. PubMed Europe PubMed DOI
[YEAR:5-1-2004]Hu,X., Zhu,J., Srivathsan,S. and Pei,D. Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors Bioorg Med Chem Lett (5-1-2004) 14, 77-79. PubMed Europe PubMed DOI I
[YEAR:1-5-2004]Kim,S., LaMontagne,K., Sabio,M., Sharma,S., Versace,R.W., Yusuff,N. and Phillips,P.E. Depletion of methionine aminopeptidase 2 does not alter cell response to fumagillin or bengamides Cancer Res (1-5-2004) 64, 2984-2987. PubMed Europe PubMed DOI I
[YEAR:15-11-2004]Nakagawa,H., Koyanagi,S., Takiguchi,T., Kuramoto,Y., Soeda,S., Shimeno,H., Higuchi,S. and Ohdo,S. 24-hour oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression, is regulated by clock gene proteins Cancer Res (15-11-2004) 64, 8328-8333. PubMed Europe PubMed DOI
[YEAR:23-2-2004]Sheppard,G.S., Wang,J., Kawai,M., BaMaung,N.Y., Craig,R.A., Erickson,S.A., Lynch,L., Patel,J., Yang,F., Searle,X.B., Lou,P., Park,C., Kim,K.H., Henkin,J. and Lesniewski,R. 3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2 Bioorg Med Chem Lett (23-2-2004) 14, 865-868. PubMed Europe PubMed DOI I

2003

[YEAR:26-12-2003]Towbin,H., Bair,K.W., DeCaprio,J.A., Eck,M.J., Kim,S., Kinder,F.R., Morollo,A., Mueller,D.R., Schindler,P., Song,H.K., van Oostrum,J., Versace,R.W., Voshol,H., Wood,J., Zabludoff,S. and Phillips,P.E. Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors J Biol Chem (26-12-2003) 278, 52964-52971. PubMed Europe PubMed DOI I
[YEAR:6-5-2003]Wang,J., Sheppard,G.S., Lou,P., Kawai,M., Park,C., Egan,D.A., Schneider,A., Bouska,J., Lesniewski,R. and Henkin,J. Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese Biochemistry (6-5-2003) 42, 5035-5042. PubMed Europe PubMed DOI
[YEAR:15-11-2003]Wang,J., Sheppard,G.S., Lou,P., Kawai,M., BaMaung,N., Erickson,S.A., Tucker-Garcia,L., Park,C., Bouska,J., Wang,Y.C., Frost,D., Tapang,P., Albert,D.H., Morgan,S.J., Morowitz,M., Shusterman,S., Maris,J.M., Lesniewski,R. and Henkin,J. Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2 Cancer Res (15-11-2003) 63, 7861-7869. PubMed Europe PubMed I
Weiss,L.M., Zhou,G.C. and Zhang,H. Characterization of recombinant microsporidian methionine aminopeptidase type 2 J Eukaryot Microbiol (2003) 50 Suppl, 597-599. PubMed Europe PubMed DOI
[YEAR:31-7-2003]Zhou,G., Tsai,C.W. and Liu,J.O. Fumagalone, a reversible inhibitor of type 2 methionine aminopeptidase and angiogenesis J Med Chem (31-7-2003) 46, 3452-3454. PubMed Europe PubMed DOI I

2002

Bradshaw,R.A. and Yi,E. Methionine aminopeptidases and angiogenesis Essays Biochem (2002) 38, 65-78. PubMed Europe PubMed
[YEAR:1-2-2002]Chen,S., Vetro,J.A. and Chang,Y.H. The specificity in vivo of two distinct methionine aminopeptidases in Saccharomyces cerevisiae Arch Biochem Biophys (1-2-2002) 398, 87-93. PubMed Europe PubMed DOI
[YEAR:19-7-2002]Endo,H., Takenaga,K., Kanno,T., Satoh,H. and Mori,S. Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4 J Biol Chem (19-7-2002) 277, 26396-26402. PubMed Europe PubMed DOI I
Kanno,T., Endo,H., Takeuchi,K., Morishita,Y., Fukayama,M. and Mori,S. High expression of methionine aminopeptidase type 2 in germinal center B cells and their neoplastic counterparts Lab Invest (2002) 82, 893-901. PubMed Europe PubMed

2001

Catalano,A., Romano,M., Robuffo,I., Strizzi,L. and Procopio,A. Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of bcl-2 expression and telomerase activity Am J Pathol (2001) 159, 721-731. PubMed Europe PubMed DOI PMC EPMC I
[YEAR:4-9-2001]Yang,G., Kirkpatrick,R.B., Ho,T., Zhang,G.F., Liang,P.H., Johanson,K.O., Casper,D.J., Doyle,M.L., Marino,J.P., Jr., Thompson,S.K., Chen,W., Tew,D.G. and Meek,T.D. Steady-state kinetic characterization of substrates and metal-ion specificities of the full-length and N-terminally truncated recombinant human methionine aminopeptidases (type 2) Biochemistry (4-9-2001) 40, 10645-10654. PubMed Europe PubMed DOI

2000

Datta,B. MAPs and POEP of the roads from prokaryotic to eukaryotic kingdoms Biochimie (2000) 82, 95-107. PubMed Europe PubMed DOI V
[YEAR:3-1-2000]Han,C.K., Ahn,S.K., Choi,N.S., Hong,R.K., Moon,S.K., Chun,H.S., Lee,S.J., Kim,J.W., Hong,C.I., Kim,D., Yoon,J.H. and No,K.T. Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2 Bioorg Med Chem Lett (3-1-2000) 10, 39-43. PubMed Europe PubMed DOI I
[YEAR:7-3-2000]Lowther,W.T. and Matthews,B.W. Structure and function of the methionine aminopeptidases Biochim Biophys Acta (7-3-2000) 1477, 157-167. PubMed Europe PubMed DOI S I
Wang,J., Lou,P. and Henkin,J. Selective inhibition of endothelial cell proliferation by fumagillin is not due to differential expression of methionine aminopeptidases J Cell Biochem (2000) 77, 465-473. PubMed Europe PubMed DOI I
[YEAR:10-4-2000]Zhou,Y., Guo,X.C., Yi,T., Yoshimoto,T. and Pei,D. Two continuous spectrophotometric assays for methionine aminopeptidase Anal Biochem (10-4-2000) 280, 159-165. PubMed Europe PubMed DOI A

1999

Cutforth,T. and Gaul,U. A methionine aminopeptidase and putative regulator of translation initiation is required for cell growth and patterning in Drosophila Mech Dev (1999) 82, 23-28. PubMed Europe PubMed DOI

1998

[YEAR:22-12-1998]Griffith,E.C., Su,Z., Niwayama,S., Ramsay,C.A., Chang,Y.H. and Liu,J.O. Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2 Proc Natl Acad Sci U S A (22-12-1998) 95, 15183-15188. PubMed Europe PubMed DOI PMC EPMC I
[YEAR:13-11-1998]Liu,S., Widom,J., Kemp,C.W., Crews,C.M. and Clardy,J. Structure of human methionine aminopeptidase-2 complexed with fumagillin Science (13-11-1998) 282, 1324-1327. PubMed Europe PubMed S I
[YEAR:13-10-1998]Lowther,W.T., McMillen,D.A., Orville,A.M. and Matthews,B.W. The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase Proc Natl Acad Sci U S A (13-10-1998) 95, 12153-12157. PubMed Europe PubMed DOI PMC EPMC I
Turk,B.E., Su,Z. and Liu,J.O. Synthetic analogues of TNP-470 and ovalicin reveal a common molecular basis for inhibition of angiogenesis and immunosuppression Bioorg Med Chem (1998) 6, 1163-1169. PubMed Europe PubMed DOI I

1997

Griffith,E.C., Su,Z., Turk,B.E., Chen,S., Chang,Y.H., Wu,Z., Biemann,K. and Liu,J.O. Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin Chem Biol (1997) 4, 461-471. PubMed Europe PubMed I
Sin,N., Meng,L., Wang,M.Q., Wen,J.J., Bornmann,W.G. and Crews,C.M. The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2 Proc Natl Acad Sci U S A (1997) 94, 6099-6103. PubMed Europe PubMed DOI PMC EPMC I

1996

Keeling,P.J. and Doolittle,W.F. Methionine aminopeptidase-1: the MAP of the mitochondrion? Trends Biochem Sci (1996) 21, 285-286. PubMed Europe PubMed
Li,X. and Chang,Y.H. Evidence that the human homologue of a rat initiation factor-2 associated protein (p67) is a methionine aminopeptidase Biochem Biophys Res Commun (1996) 227, 152-159. PubMed Europe PubMed DOI

1995

Arfin,S.M., Kendall,R.L., Hall,L., Weaver,L.H., Stewart,A.E., Matthews,B.W. and Bradshaw,R.A. Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes Proc Natl Acad Sci U S A (1995) 92, 7714-7718. PubMed Europe PubMed DOI PMC EPMC
Li,X. and Chang,Y.H. Amino-terminal protein processing in Saccharomyces cerevisiae is an essential function that requires two distinct methionine aminopeptidases Proc Natl Acad Sci U S A (1995) 92, 12357-12361. PubMed Europe PubMed DOI PMC EPMC

1987

[YEAR:15-12-1987]Huang,S., Elliott,R.C., Liu,P.S., Koduri,R.K., Weickmann,J.L., Lee,J.H., Blair,L.C., Ghosh-Dastidar,P., Bradshaw,R.A. and Bryan,K.M. Specificity of cotranslational amino-terminal processing of proteins in yeast Biochemistry (15-12-1987) 26, 8242-8246. PubMed Europe PubMed

1986

[YEAR:2-1-1986]Flinta,C., Persson,B., Jornvall,H. and von Heijne,G. Sequence determinants of cytosolic N-terminal protein processing Eur J Biochem (2-1-1986) 154, 193-196. PubMed Europe PubMed

1985

Freitas,J.O., Jr., Termignoni,C. and Guimaraes,J.A. Microsomal methionine aminopeptidase: properties of the detergent-solubilized enzyme Int J Biochem (1985) 17, 1285-1291. PubMed Europe PubMed