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Literature for peptidase M24.002: methionyl aminopeptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Cornelius,P., Mayes,B.A., Petersen,J.S., Turnquist,D.J., Dufour,P.J., Dannenberg,A.J., Shanahan,J.M. and Carver,B.J.
    Pharmacological Characterization of SDX-7320/Evexomostat: a Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-Tumor and Anti-Metastatic Activity
    Mol Cancer Ther23, 595-605. PubMed  Europe PubMed DOI  I
  2. Friese-Hamim,M., Ortiz Ruiz,M.J., Bogatyrova,O., Keil,M., Rohdich,F., Blume,B., Leuthner,B., Czauderna,F., Hahn,D., Jabs,J., Jaehrling,F., Heinrich,T., Kellner,R., Chan,K., Tong,A.H.Y., Wienke,D., Moffat,J., Blaukat,A. and Zenke,F.T.
    Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models
    Mol Cancer Ther23, 159-173. PubMed  Europe PubMed DOI  I
  3. Klein,M.A., Wild,K., Kisonaite,M. and Sinning,I.
    Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome
    Nat Commun15, 716-716. PubMed  Europe PubMed DOI
  4. Rubina, Moin,S.T. and Haider,S.
    Identification of a Cryptic Pocket in Methionine Aminopeptidase-II Using Adaptive Bandit Molecular Dynamics Simulations and Markov State Models
    ACS Omega9, 28534-28545. PubMed  Europe PubMed DOI
    5. 2023
  5. Bala,S., Reddi,B. and Addlagatta,A.
    A single amino acid difference between archaeal and human type 2 methionine aminopeptidases differentiates their affinity towards ovalicin
    Biochim Biophys Acta Proteins Proteom1871, 140881-140881. PubMed  Europe PubMed DOI  I
  6. Lignet,F., Friese-Hamim,M., Jaehrling,F., El Bawab,S. and Rohdich,F.
    Preclinical Pharmacokinetics and Translational Pharmacokinetic/Pharmacodynamic Modeling of M8891, a Potent and Reversible Inhibitor of Methionine Aminopeptidase 2
    Pharm Res40, 3011-3023. PubMed  Europe PubMed DOI  I
    7. 2022
  7. Shimizu,S., Kawahara,R. and Simizu,S.
    Methionine aminopeptidase2 is a pivotal regulator of vasculogenic mimicry
    Oncol Rep47, PubMed  Europe PubMed DOI
    8. 2021
  8. Albayati,S., Uba,A.I. and Yelekci,K.
    Potential inhibitors of methionine aminopeptidase type II identified via structure-based pharmacophore modeling
    Mol Divers PubMed  Europe PubMed DOI
  9. Craig,S.L., Gault,V.A., Flatt,P.R. and Irwin,N.
    The methionine aminopeptidase 2 inhibitor, TNP-470, enhances the antidiabetic properties of sitagliptin in mice by upregulating xenin
    Biochem Pharmacol183, 114355-114355. PubMed  Europe PubMed DOI  I
  10. Goya Grocin,A., Kallemeijn,W.W. and Tate,E.W.
    Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity
    Trends Pharmacol Sci42, 870-882. PubMed  Europe PubMed DOI
    11. 2020
  11. Esa,R., Steinberg,E., Dror,D., Schwob,O., Khajavi,M., Maoz,M., Kinarty,Y., Inbal,A., Zick,A. and Benny,O.
    The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis
    Int J Mol Sci21, 5148-5148. PubMed  Europe PubMed DOI
  12. Weako,J., Uba,A.I., Keskin,O., Gursoy,A. and Yelekci,K.
    Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: structure-based virtual screening, ADMET prediction and molecular dynamics studies
    Comput Biol Chem86, 107244-107244. PubMed  Europe PubMed DOI
  13. Wentworth,J.M. and Colman,P.G.
    The methionine aminopeptidase 2 inhibitor ZGN-1061 improves glucose control and weight in overweight and obese individuals with type 2 diabetes: a randomized, placebo-controlled trial
    Diabetes Obes Metab22, 1215-1219. PubMed  Europe PubMed DOI  I
    14. 2019
  14. Heinrich,T., Seenisamy,J., Becker,F., Blume,B., Bomke,J., Dietz,M., Eckert,U., Friese-Hamim,M., Gunera,J., Hansen,K., Leuthner,B., Musil,D., Pfalzgraf,J., Rohdich,F., Siegl,C., Spuck,D., Wegener,A. and Zenke,F.T.
    Identification of methionine aminopeptidase-2 (MetAP-2) inhibitor M8891: a clinical compound for the treatment of cancer
    J Med Chem62, 11119-11134. PubMed  Europe PubMed DOI  I
  15. Heinrich,T., Seenisamy,J., Blume,B., Bomke,J., Calderini,M., Eckert,U., Friese-Hamim,M., Kohl,R., Lehmann,M., Leuthner,B., Musil,D., Rohdich,F. and Zenke,F.T.
    Discovery and structure-based optimization of next-generation reversible methionine aminopeptidase-2 (MetAP-2) inhibitors
    J Med Chem62, 5025-5039. PubMed  Europe PubMed DOI  I
    16. 2018
  16. Bhat,S.Y., Dey,A. and Qureshi,I.A.
    Structural and functional highlights of methionine aminopeptidase 2 from Leishmania donovani
    Int J Biol Macromol115, 940-954. PubMed  Europe PubMed DOI
  17. Coruh,I., Cevik,O., Yelekci,K., Djikic,T. and Kucukguzel,S.G.
    Synthesis, anticancer activity, and molecular modeling of etodolac-thioether derivatives as potent methionine aminopeptidase (type II) inhibitors
    Arch Pharm (Weinheim)351, e1700195-e1700195. PubMed  Europe PubMed DOI  I
  18. Esvaran,V.G., Gupta,T., Nayaka,A.R.N., Sivaprasad,V. and Ponnuvel,K.M.
    Molecular characterization of Nosema bombycis methionine aminopeptidase 2 (MetAP2) gene and evaluation of anti-microsporidian activity of fumagilin-B in silkworm Bombyx mori
    3 Biotech8, 386-386. PubMed  Europe PubMed DOI
  19. Lin,M., Zhang,X., Jia,B. and Guan,S.
    Suppression of glioblastoma growth and angiogenesis through molecular targeting of methionine aminopeptidase-2
    J Neurooncol136, 243-254. PubMed  Europe PubMed DOI  K
    20. 2017
  20. Heinrich,T., Buchstaller,H.P., Cezanne,B., Rohdich,F., Bomke,J., Friese-Hamim,M., Krier,M., Knochel,T., Musil,D., Leuthner,B. and Zenke,F.
    Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates
    Bioorg Med Chem Lett27, 551-556. PubMed  Europe PubMed DOI  I
  21. Kumar,R., Tiwari,K. and Dubey,V.K.
    Methionine aminopeptidase 2 is a key regulator of apoptotic like cell death in Leishmania donovani
    Sci Rep7, 95-95. PubMed  Europe PubMed DOI  I
    22. 2016
  22. Cheruvallath,Z., Tang,M., McBride,C., Komandla,M., Miura,J., Ton-Nu,T., Erikson,P., Feng,J., Farrell,P., Lawson,J.D., Vanderpool,D., Wu,Y., Dougan,D.R., Plonowski,A., Holub,C. and Larson,C.
    Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 1
    Bioorg Med Chem Lett26, 2774-2778. PubMed  Europe PubMed DOI  I
  23. Ehlers,T., Furness,S., Robinson,T.P., Zhong,H.A., Goldsmith,D., Aribser,J. and Bowen,J.P.
    Methionine aminopeptidase type-2 inhibitors targeting angiogenesis
    Curr Top Med Chem16, 1478-1488. PubMed  Europe PubMed  V  I
  24. McBride,C., Cheruvallath,Z., Komandla,M., Tang,M., Farrell,P., Lawson,J.D., Vanderpool,D., Wu,Y., Dougan,D.R., Plonowski,A., Holub,C. and Larson,C.
    Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 2
    Bioorg Med Chem Lett26, 2779-2783. PubMed  Europe PubMed DOI  I
  25. Morgen,M., Jost,C., Malz,M., Janowski,R., Niessing,D., Klein,C.D., Gunkel,N. and Miller,A.K.
    Spiroepoxytriazoles are fumagillin-like irreversible inhibitors of MetAP2 with potent cellular activity
    ACS Chem Biol11, 1001-1011. PubMed  Europe PubMed DOI  I
  26. Shimizu,H., Yamagishi,S., Chiba,H. and Ghazizadeh,M.
    Methionine aminopeptidase 2 as a potential therapeutic target for human non-small-cell lung cancers
    Adv Clin Exp Med25, 117-128. PubMed  Europe PubMed  T
  27. Weglarz-Tomczak,E., Burda-Grabowska,M., Giurg,M. and Mucha,A.
    Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: synthesis, inhibitory activity and molecular modeling study
    Bioorg Med Chem Lett26, 5254-5259. PubMed  Europe PubMed DOI  I
    28. 2015
  28. Kang,J.M., Ju,J.W., Kim,J.Y., Ju,H.L., Lee,J., Lee,K.H., Lee,W.J., Sohn,W.M., Kim,T.S. and Na,B.K.
    Expression and biochemical characterization of a type I methionine aminopeptidase of Plasmodium vivax
    Protein Expr Purif108C, 48-53. PubMed  Europe PubMed DOI  E
  29. Rosse,G.
    Pyridinonaphthyridinone inhibitors of type 2 methionine aminopeptidase
    ACS Med Chem Lett6, 622-623. PubMed  Europe PubMed DOI  I
    30. 2014
  30. Chiu,J., Wong,J.W. and Hogg,P.J.
    Redox regulation of methionine aminopeptidase 2 activity
    J Biol Chem289, 15035-15043. PubMed  Europe PubMed DOI
  31. Joharapurkar,A.A., Dhanesha,N.A. and Jain,M.R.
    Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity
    Diabetes Metab Syndr Obes7, 73-84. PubMed  Europe PubMed DOI  T  I
    32. 2013
  32. Bonissone,S., Gupta,N., Romine,M., Bradshaw,R.A. and Pevzner,P.A.
    N-terminal protein processing: a comparative proteogenomic analysis
    Mol Cell Proteomics12, 14-28. PubMed  Europe PubMed
  33. Clinkinbeard,T., Ghoshal,S., Craddock,S., Creed Pettigrew,L. and Guttmann,R.P.
    Calpain cleaves methionine aminopeptidase-2 in a rat model of ischemia/reperfusion
    Brain Res1499, 129-135. PubMed  Europe PubMed DOI
  34. [YEAR:1-9-2013]Hughes,T.E., Kim D.D., Marjason,J., Proietto,J., Whitehead J.P. and Vath,J.E.
    Ascending dose-controlled trial of beloranib, a novel obesity treatment for safety, tolerability, and weight loss in obese women
    Obesity (Silver Spring, Md )21, 1782-1788. PubMed  Europe PubMed  I
  35. Ng,J.Y., Chiu,J., Hogg,P.J. and Wong,J.W.
    Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2
    Biochem Biophys Res Commun440, 37-42. PubMed  Europe PubMed DOI
  36. Sun,J., Li,M.H., Qian,S.S., Guo,F.J., Dang,X.F., Wang,X.M., Xue,Y.R. and Zhu,H.L.
    Synthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors
    Bioorg Med Chem Lett23, 2876-2879. PubMed  Europe PubMed DOI  I
    37. 2012
  37. Bradshaw,R.A. and Walker,K.W.
    Methionyl aminopeptidase type 2
    [ISSN:978-0-12-407743-0]3, 1501-1506. DOI
    38. 2011
  38. Hou,Y.P., Sun,J., Pang,Z.H., Lv,P.C., Li,D.D., Yan,L., Zhang,H.J., Zheng,E.X., Zhao,J. and Zhu,H.L.
    Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors
    Bioorg Med Chem19, 5948-5954. PubMed  Europe PubMed DOI  I
  39. Ma,A.C., Fung,T.K., Lin,R.H., Chung,M.I., Yang,D., Ekker,S.C. and Leung,A.Y.
    Methionine aminopeptidase 2 is required for HSC initiation and proliferation
    Blood118, 5448-5457. PubMed  Europe PubMed DOI  I
  40. Shapiro,A.B., Gao,N., Thresher,J., Walkup,G.K. and Whiteaker,J.
    A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase
    J Biomol Screen16, 494-505. PubMed  Europe PubMed DOI  A
    41. 2010
  41. Peng,J., Han,H., Hong,Y., Fu,Z., Liu,J. and Lin,J.
    Molecular cloning and characterization of a gene encoding methionine aminopeptidase 2 of Schistosoma japonicum
    Parasitol Res107, 939-946. PubMed  Europe PubMed DOI
  42. Shahlaei,M., Sabet,R., Ziari,M.B., Moeinifard,B., Fassihi,A. and Karbakhsh,R.
    QSAR study of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2 using LS-SVM and GRNN based on principal components
    Eur J Med Chem45, 4499-4508. PubMed  Europe PubMed DOI  I
    43. 2009
  43. Alvarado,J.J., Nemkal,A., Sauder,J.M., Russell,M., Akiyoshi,D.E., Shi,W., Almo,S.C. and Weiss,L.M.
    Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470
    Mol Biochem Parasitol168, 158-167. PubMed  Europe PubMed DOI  S  I
  44. Arico-Muendel,C.C., Benjamin,D.R., Caiazzo,T.M., Centrella,P.A., Contonio,B.D., Cook,C.M., Doyle,E.G., Hannig,G., Labenski,M.T., Searle,L.L., Lind,K., Morgan,B.A., Olson,G., Paradise,C.L., Self,C., Skinner,S.R., Sluboski,B., Svendsen,J.L., Thompson,C.D., Westlin,W. and White,K.F.
    Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2
    J Med Chem52, 8047-8056. PubMed  Europe PubMed DOI  I
  45. Chen,X., Xie,S., Bhat,S., Kumar,N., Shapiro,T.A. and Liu,J.O.
    Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo
    Chem Biol16, 193-202. PubMed  Europe PubMed DOI  I
    46. 2008
  46. Lazarus,D.D., Doyle,E.G., Bernier,S.G., Rogers,A.B., Labenski,M.T., Wakefield,J.D., Karp,R.M., Clark,E.J., Lorusso,J., Hoyt,J.G., Thompson,C.D., Hannig,G. and Westlin,W.F.
    An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis
    Inflamm Res57, 18-27. PubMed  Europe PubMed DOI  I
  47. Tucker,L.A., Zhang,Q., Sheppard,G.S., Lou,P., Jiang,F., McKeegan,E., Lesniewski,R., Davidsen,S.K., Bell,R.L. and Wang,J.
    Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation
    Oncogene27, 3967-3976. PubMed  Europe PubMed DOI
  48. Warder,S.E., Tucker,L.A., McLoughlin,S.M., Strelitzer,T.J., Meuth,J.L., Zhang,Q., Sheppard,G.S., Richardson,P.L., Lesniewski,R., Davidsen,S.K., Bell,R.L., Rogers,J.C. and Wang,J.
    Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition
    J Proteome Res7, 4807-4820. PubMed  Europe PubMed DOI  P
    49. 2007
  49. Bainbridge,J., Madden,L., Essex,D., Binks,M., Malhotra,R. and Paleolog,E.M.
    Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition
    Arthritis Res Ther9, R127-R127. PubMed  Europe PubMed DOI  I
  50. Kass,D., Bridges,R.S., Borczuk,A. and Greenberg,S.
    Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis
    Am J Respir Cell Mol Biol37, 193-201. PubMed  Europe PubMed DOI  T
  51. Marino,J.P., Jr., Fisher,P.W., Hofmann,G.A., Kirkpatrick,R.B., Janson,C.A., Johnson,R.K., Ma,C., Mattern,M., Meek,T.D., Ryan,M.D., Schulz,C., Smith,W.W., Tew,D.G., Tomazek,T.A., Jr., Veber,D.F., Xiong,W.C., Yamamoto,Y., Yamashita,K., Yang,G. and Thompson,S.K.
    Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore
    J Med Chem50, 3777-3785. PubMed  Europe PubMed DOI  S  I
  52. Noguchi,S., Komiya,T., Eguchi,H., Shirahata,A., Nikawa,J. and Kawamura,M.
    Methionine aminopeptidase II: a molecular chaperone for sarcoplasmic reticulum calcium ATPase
    J Membr Biol215, 105-110. PubMed  Europe PubMed DOI
  53. Sawanyawisuth,K., Wongkham,C., Pairojkul,C., Saeseow,O.T., Riggins,G.J., Araki,N. and Wongkham,S.
    Methionine aminopeptidase 2 over-expressed in cholangiocarcinoma: potential for drug target
    Acta Oncol46, 378-385. PubMed  Europe PubMed DOI  T
  54. Wang,G.T., Mantei,R.A., Kawai,M., Tedrow,J.S., Barnes,D.M., Wang,J., Zhang,Q., Lou,P., Garcia,L.A., Bouska,J., Yates,M., Park,C., Judge,R.A., Lesniewski,R., Sheppard,G.S. and Bell,R.L.
    Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids
    Bioorg Med Chem Lett17, 2817-2822. PubMed  Europe PubMed DOI  I
    55. 2006
  55. Hu,X., Addlagatta,A., Matthews,B.W. and Liu,J.O.
    Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases
    Angew Chem Int Ed Engl45, 3772-3775. PubMed  Europe PubMed DOI  S  I
  56. Selvakumar,P., Lakshmikuttyamma,A., Dimmock,J.R. and Sharma,R.K.
    Methionine aminopeptidase 2 and cancer
    Biochim Biophys Acta1765, 148-154. PubMed  Europe PubMed DOI
  57. [YEAR:17-8-2006]Upadhya,R., Zhang,H.S. and Weiss,L.M.
    System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiae
    Antimicrob Agents Chemother50, 3389-3395. PubMed  Europe PubMed DOI  E
    58. 2005
  58. Addlagatta,A., Hu,X., Liu,J.O. and Matthews,B.W.
    Structural basis for the functional differences between type I and type II human methionine aminopeptidases
    Biochemistry44, 14741-14749. PubMed  Europe PubMed DOI  S  I
  59. [YEAR:10-3-2005]Chun,E., Han,C.K., Yoon,J.H., Sim,T.B., Kim,Y.K. and Lee,K.Y.
    Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model
    Int J Cancer114, 124-130. PubMed  Europe PubMed DOI  I
  60. [YEAR:1-3-2005]Vetro,J.A., Dummitt,B., Micka,W.S. and Chang,Y.H.
    Evidence of a dominant negative mutant of yeast methionine aminopeptidase type 2 in Saccharomyces cerevisiae
    J Cell Biochem94, 656-668. PubMed  Europe PubMed DOI
    61. 2004
  61. [YEAR:9-8-2004]Asami,Y., Kakeya,H., Onose,R., Chang,Y.H., Toi,M. and Osada,H.
    RK-805, an endothelial-cell-growth inhibitor produced by Neosartorya sp., and a docking model with methionine aminopeptidase-2
    Tetrahedron60, 7085-7091. DOI  I
  62. [YEAR:8-10-2004]Boxem,M., Tsai,C.W., Zhang,Y., Saito,R.M. and Liu,J.O.
    The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation
    FEBS Lett576, 245-250. PubMed  Europe PubMed DOI  K  I
  63. Bradshaw,R.A., Yi,E. and Walker,K.W.
    Methionyl aminopeptidase type II
    [ISSN:0-12-079610-4]2, 917-922.  V
  64. [YEAR:5-3-2004]Brdlik,C.M. and Crews,C.M.
    A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases
    J Biol Chem279, 9475-9480. PubMed  Europe PubMed DOI  I
  65. Giglione,C., Boularot,A. and Meinnel,T.
    Protein N-terminal methionine excision
    Cell Mol Life Sci61, 1455-1474. PubMed  Europe PubMed DOI
  66. [YEAR:5-1-2004]Hu,X., Zhu,J., Srivathsan,S. and Pei,D.
    Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors
    Bioorg Med Chem Lett14, 77-79. PubMed  Europe PubMed DOI  I
  67. [YEAR:1-5-2004]Kim,S., LaMontagne,K., Sabio,M., Sharma,S., Versace,R.W., Yusuff,N. and Phillips,P.E.
    Depletion of methionine aminopeptidase 2 does not alter cell response to fumagillin or bengamides
    Cancer Res64, 2984-2987. PubMed  Europe PubMed DOI  I
  68. [YEAR:15-11-2004]Nakagawa,H., Koyanagi,S., Takiguchi,T., Kuramoto,Y., Soeda,S., Shimeno,H., Higuchi,S. and Ohdo,S.
    24-hour oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression, is regulated by clock gene proteins
    Cancer Res64, 8328-8333. PubMed  Europe PubMed DOI
  69. [YEAR:23-2-2004]Sheppard,G.S., Wang,J., Kawai,M., BaMaung,N.Y., Craig,R.A., Erickson,S.A., Lynch,L., Patel,J., Yang,F., Searle,X.B., Lou,P., Park,C., Kim,K.H., Henkin,J. and Lesniewski,R.
    3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2
    Bioorg Med Chem Lett14, 865-868. PubMed  Europe PubMed DOI  I
    70. 2003
  70. [YEAR:26-12-2003]Towbin,H., Bair,K.W., DeCaprio,J.A., Eck,M.J., Kim,S., Kinder,F.R., Morollo,A., Mueller,D.R., Schindler,P., Song,H.K., van Oostrum,J., Versace,R.W., Voshol,H., Wood,J., Zabludoff,S. and Phillips,P.E.
    Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors
    J Biol Chem278, 52964-52971. PubMed  Europe PubMed DOI  I
  71. [YEAR:15-11-2003]Wang,J., Sheppard,G.S., Lou,P., Kawai,M., BaMaung,N., Erickson,S.A., Tucker-Garcia,L., Park,C., Bouska,J., Wang,Y.C., Frost,D., Tapang,P., Albert,D.H., Morgan,S.J., Morowitz,M., Shusterman,S., Maris,J.M., Lesniewski,R. and Henkin,J.
    Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2
    Cancer Res63, 7861-7869. PubMed  Europe PubMed  I
  72. [YEAR:6-5-2003]Wang,J., Sheppard,G.S., Lou,P., Kawai,M., Park,C., Egan,D.A., Schneider,A., Bouska,J., Lesniewski,R. and Henkin,J.
    Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese
    Biochemistry42, 5035-5042. PubMed  Europe PubMed DOI
  73. Weiss,L.M., Zhou,G.C. and Zhang,H.
    Characterization of recombinant microsporidian methionine aminopeptidase type 2
    J Eukaryot Microbiol50 Suppl, 597-599. PubMed  Europe PubMed DOI
  74. [YEAR:31-7-2003]Zhou,G., Tsai,C.W. and Liu,J.O.
    Fumagalone, a reversible inhibitor of type 2 methionine aminopeptidase and angiogenesis
    J Med Chem46, 3452-3454. PubMed  Europe PubMed DOI  I
    75. 2002
  75. Bradshaw,R.A. and Yi,E.
    Methionine aminopeptidases and angiogenesis
    Essays Biochem38, 65-78. PubMed  Europe PubMed
  76. [YEAR:1-2-2002]Chen,S., Vetro,J.A. and Chang,Y.H.
    The specificity in vivo of two distinct methionine aminopeptidases in Saccharomyces cerevisiae
    Arch Biochem Biophys398, 87-93. PubMed  Europe PubMed DOI
  77. [YEAR:19-7-2002]Endo,H., Takenaga,K., Kanno,T., Satoh,H. and Mori,S.
    Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4
    J Biol Chem277, 26396-26402. PubMed  Europe PubMed DOI  I
  78. Kanno,T., Endo,H., Takeuchi,K., Morishita,Y., Fukayama,M. and Mori,S.
    High expression of methionine aminopeptidase type 2 in germinal center B cells and their neoplastic counterparts
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    79. 2001
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