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Literature for peptidase M24.002: methionyl aminopeptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Osana,S., Tsai,C.T., Suzuki,N., Murayama,K., Kaneko,M., Hata,K., Takada,H., Kano,Y. and Nagatomi,R.
    Inhibition of methionine aminopeptidase in C2C12 myoblasts disrupts cell integrity via increasing endoplasmic reticulum stress
    Biochim Biophys Acta Mol Cell Res (2025) 1872, 119901-119901. PubMed  Europe PubMed DOI  K
    2. 2024
  2. Cornelius,P., Mayes,B.A., Petersen,J.S., Turnquist,D.J., Dufour,P.J., Dannenberg,A.J., Shanahan,J.M. and Carver,B.J.
    Pharmacological Characterization of SDX-7320/Evexomostat: a Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-Tumor and Anti-Metastatic Activity
    Mol Cancer Ther (2024) 23, 595-605. PubMed  Europe PubMed DOI  I
  3. Friese-Hamim,M., Ortiz Ruiz,M.J., Bogatyrova,O., Keil,M., Rohdich,F., Blume,B., Leuthner,B., Czauderna,F., Hahn,D., Jabs,J., Jaehrling,F., Heinrich,T., Kellner,R., Chan,K., Tong,A.H.Y., Wienke,D., Moffat,J., Blaukat,A. and Zenke,F.T.
    Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models
    Mol Cancer Ther (2024) 23, 159-173. PubMed  Europe PubMed DOI  PMC  EPMC  I
  4. Klein,M.A., Wild,K., Kisonaite,M. and Sinning,I.
    Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome
    Nat Commun (2024) 15, 716-716. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Rubina, Moin,S.T. and Haider,S.
    Identification of a Cryptic Pocket in Methionine Aminopeptidase-II Using Adaptive Bandit Molecular Dynamics Simulations and Markov State Models
    ACS Omega (2024) 9, 28534-28545. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Bala,S., Reddi,B. and Addlagatta,A.
    A single amino acid difference between archaeal and human type 2 methionine aminopeptidases differentiates their affinity towards ovalicin
    Biochim Biophys Acta Proteins Proteom (2023) 1871, 140881-140881. PubMed  Europe PubMed DOI  I
  7. Lignet,F., Friese-Hamim,M., Jaehrling,F., El Bawab,S. and Rohdich,F.
    Preclinical Pharmacokinetics and Translational Pharmacokinetic/Pharmacodynamic Modeling of M8891, a Potent and Reversible Inhibitor of Methionine Aminopeptidase 2
    Pharm Res (2023) 40, 3011-3023. PubMed  Europe PubMed DOI  PMC  EPMC  I
    8. 2022
  8. Shimizu,S., Kawahara,R. and Simizu,S.
    Methionine aminopeptidase2 is a pivotal regulator of vasculogenic mimicry
    Oncol Rep (2022) 47 PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2021
  9. Albayati,S., Uba,A.I. and Yelekci,K.
    Potential inhibitors of methionine aminopeptidase type II identified via structure-based pharmacophore modeling
    Mol Divers (2021) PubMed  Europe PubMed DOI
  10. Craig,S.L., Gault,V.A., Flatt,P.R. and Irwin,N.
    The methionine aminopeptidase 2 inhibitor, TNP-470, enhances the antidiabetic properties of sitagliptin in mice by upregulating xenin
    Biochem Pharmacol (2021) 183, 114355-114355. PubMed  Europe PubMed DOI  I
  11. Goya Grocin,A., Kallemeijn,W.W. and Tate,E.W.
    Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity
    Trends Pharmacol Sci (2021) 42, 870-882. PubMed  Europe PubMed DOI
    12. 2020
  12. Esa,R., Steinberg,E., Dror,D., Schwob,O., Khajavi,M., Maoz,M., Kinarty,Y., Inbal,A., Zick,A. and Benny,O.
    The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis
    Int J Mol Sci (2020) 21, 5148-5148. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Weako,J., Uba,A.I., Keskin,O., Gursoy,A. and Yelekci,K.
    Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: structure-based virtual screening, ADMET prediction and molecular dynamics studies
    Comput Biol Chem (2020) 86, 107244-107244. PubMed  Europe PubMed DOI
  14. Wentworth,J.M. and Colman,P.G.
    The methionine aminopeptidase 2 inhibitor ZGN-1061 improves glucose control and weight in overweight and obese individuals with type 2 diabetes: a randomized, placebo-controlled trial
    Diabetes Obes Metab (2020) 22, 1215-1219. PubMed  Europe PubMed DOI  I
    15. 2019
  15. Heinrich,T., Seenisamy,J., Blume,B., Bomke,J., Calderini,M., Eckert,U., Friese-Hamim,M., Kohl,R., Lehmann,M., Leuthner,B., Musil,D., Rohdich,F. and Zenke,F.T.
    Discovery and structure-based optimization of next-generation reversible methionine aminopeptidase-2 (MetAP-2) inhibitors
    J Med Chem (2019) 62, 5025-5039. PubMed  Europe PubMed DOI  I
  16. Heinrich,T., Seenisamy,J., Becker,F., Blume,B., Bomke,J., Dietz,M., Eckert,U., Friese-Hamim,M., Gunera,J., Hansen,K., Leuthner,B., Musil,D., Pfalzgraf,J., Rohdich,F., Siegl,C., Spuck,D., Wegener,A. and Zenke,F.T.
    Identification of methionine aminopeptidase-2 (MetAP-2) inhibitor M8891: a clinical compound for the treatment of cancer
    J Med Chem (2019) 62, 11119-11134. PubMed  Europe PubMed DOI  I
    17. 2018
  17. Bhat,S.Y., Dey,A. and Qureshi,I.A.
    Structural and functional highlights of methionine aminopeptidase 2 from Leishmania donovani
    Int J Biol Macromol (2018) 115, 940-954. PubMed  Europe PubMed DOI
  18. Coruh,I., Cevik,O., Yelekci,K., Djikic,T. and Kucukguzel,S.G.
    Synthesis, anticancer activity, and molecular modeling of etodolac-thioether derivatives as potent methionine aminopeptidase (type II) inhibitors
    Arch Pharm (Weinheim) (2018) 351, e1700195-e1700195. PubMed  Europe PubMed DOI  I
  19. Esvaran,V.G., Gupta,T., Nayaka,A.R.N., Sivaprasad,V. and Ponnuvel,K.M.
    Molecular characterization of Nosema bombycis methionine aminopeptidase 2 (MetAP2) gene and evaluation of anti-microsporidian activity of fumagilin-B in silkworm Bombyx mori
    3 Biotech (2018) 8, 386-386. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Lin,M., Zhang,X., Jia,B. and Guan,S.
    Suppression of glioblastoma growth and angiogenesis through molecular targeting of methionine aminopeptidase-2
    J Neurooncol (2018) 136, 243-254. PubMed  Europe PubMed DOI  K
    21. 2017
  21. Heinrich,T., Buchstaller,H.P., Cezanne,B., Rohdich,F., Bomke,J., Friese-Hamim,M., Krier,M., Knochel,T., Musil,D., Leuthner,B. and Zenke,F.
    Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates
    Bioorg Med Chem Lett (2017) 27, 551-556. PubMed  Europe PubMed DOI  I
  22. Kumar,R., Tiwari,K. and Dubey,V.K.
    Methionine aminopeptidase 2 is a key regulator of apoptotic like cell death in Leishmania donovani
    Sci Rep (2017) 7, 95-95. PubMed  Europe PubMed DOI  I
    23. 2016
  23. Cheruvallath,Z., Tang,M., McBride,C., Komandla,M., Miura,J., Ton-Nu,T., Erikson,P., Feng,J., Farrell,P., Lawson,J.D., Vanderpool,D., Wu,Y., Dougan,D.R., Plonowski,A., Holub,C. and Larson,C.
    Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 1
    Bioorg Med Chem Lett (2016) 26, 2774-2778. PubMed  Europe PubMed DOI  I
  24. Ehlers,T., Furness,S., Robinson,T.P., Zhong,H.A., Goldsmith,D., Aribser,J. and Bowen,J.P.
    Methionine aminopeptidase type-2 inhibitors targeting angiogenesis
    Curr Top Med Chem (2016) 16, 1478-1488. PubMed  Europe PubMed  V  I
  25. McBride,C., Cheruvallath,Z., Komandla,M., Tang,M., Farrell,P., Lawson,J.D., Vanderpool,D., Wu,Y., Dougan,D.R., Plonowski,A., Holub,C. and Larson,C.
    Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 2
    Bioorg Med Chem Lett (2016) 26, 2779-2783. PubMed  Europe PubMed DOI  I
  26. Morgen,M., Jost,C., Malz,M., Janowski,R., Niessing,D., Klein,C.D., Gunkel,N. and Miller,A.K.
    Spiroepoxytriazoles are fumagillin-like irreversible inhibitors of MetAP2 with potent cellular activity
    ACS Chem Biol (2016) 11, 1001-1011. PubMed  Europe PubMed DOI  I
  27. Shimizu,H., Yamagishi,S., Chiba,H. and Ghazizadeh,M.
    Methionine aminopeptidase 2 as a potential therapeutic target for human non-small-cell lung cancers
    Adv Clin Exp Med (2016) 25, 117-128. PubMed  Europe PubMed  T
  28. Weglarz-Tomczak,E., Burda-Grabowska,M., Giurg,M. and Mucha,A.
    Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: synthesis, inhibitory activity and molecular modeling study
    Bioorg Med Chem Lett (2016) 26, 5254-5259. PubMed  Europe PubMed DOI  I
    29. 2015
  29. Kang,J.M., Ju,J.W., Kim,J.Y., Ju,H.L., Lee,J., Lee,K.H., Lee,W.J., Sohn,W.M., Kim,T.S. and Na,B.K.
    Expression and biochemical characterization of a type I methionine aminopeptidase of Plasmodium vivax
    Protein Expr Purif (2015) 108C, 48-53. PubMed  Europe PubMed DOI  E
  30. Rosse,G.
    Pyridinonaphthyridinone inhibitors of type 2 methionine aminopeptidase
    ACS Med Chem Lett (2015) 6, 622-623. PubMed  Europe PubMed DOI  PMC  EPMC  I
    31. 2014
  31. Chiu,J., Wong,J.W. and Hogg,P.J.
    Redox regulation of methionine aminopeptidase 2 activity
    J Biol Chem (2014) 289, 15035-15043. PubMed  Europe PubMed DOI
  32. Joharapurkar,A.A., Dhanesha,N.A. and Jain,M.R.
    Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity
    Diabetes Metab Syndr Obes (2014) 7, 73-84. PubMed  Europe PubMed DOI  PMC  EPMC  T  I
    33. 2013
  33. Bonissone,S., Gupta,N., Romine,M., Bradshaw,R.A. and Pevzner,P.A.
    N-terminal protein processing: a comparative proteogenomic analysis
    Mol Cell Proteomics (2013) 12, 14-28. PubMed  Europe PubMed
  34. Clinkinbeard,T., Ghoshal,S., Craddock,S., Creed Pettigrew,L. and Guttmann,R.P.
    Calpain cleaves methionine aminopeptidase-2 in a rat model of ischemia/reperfusion
    Brain Res (2013) 1499, 129-135. PubMed  Europe PubMed DOI
  35. [YEAR:1-9-2013]Hughes,T.E., Kim D.D., Marjason,J., Proietto,J., Whitehead J.P. and Vath,J.E.
    Ascending dose-controlled trial of beloranib, a novel obesity treatment for safety, tolerability, and weight loss in obese women
    Obesity (Silver Spring, Md.) (1-9-2013) 21, 1782-1788. PubMed  Europe PubMed  I
  36. Ng,J.Y., Chiu,J., Hogg,P.J. and Wong,J.W.
    Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2
    Biochem Biophys Res Commun (2013) 440, 37-42. PubMed  Europe PubMed DOI
  37. Sun,J., Li,M.H., Qian,S.S., Guo,F.J., Dang,X.F., Wang,X.M., Xue,Y.R. and Zhu,H.L.
    Synthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors
    Bioorg Med Chem Lett (2013) 23, 2876-2879. PubMed  Europe PubMed DOI  I
    38. 2012
  38. Bradshaw,R.A. and Walker,K.W.
    Methionyl aminopeptidase type 2
    [ISSN:978-0-12-407743-0] (2012) 3, 1501-1506. DOI
    39. 2011
  39. Hou,Y.P., Sun,J., Pang,Z.H., Lv,P.C., Li,D.D., Yan,L., Zhang,H.J., Zheng,E.X., Zhao,J. and Zhu,H.L.
    Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors
    Bioorg Med Chem (2011) 19, 5948-5954. PubMed  Europe PubMed DOI  I
  40. Ma,A.C., Fung,T.K., Lin,R.H., Chung,M.I., Yang,D., Ekker,S.C. and Leung,A.Y.
    Methionine aminopeptidase 2 is required for HSC initiation and proliferation
    Blood (2011) 118, 5448-5457. PubMed  Europe PubMed DOI  I
  41. Shapiro,A.B., Gao,N., Thresher,J., Walkup,G.K. and Whiteaker,J.
    A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase
    J Biomol Screen (2011) 16, 494-505. PubMed  Europe PubMed DOI  A
    42. 2010
  42. Peng,J., Han,H., Hong,Y., Fu,Z., Liu,J. and Lin,J.
    Molecular cloning and characterization of a gene encoding methionine aminopeptidase 2 of Schistosoma japonicum
    Parasitol Res (2010) 107, 939-946. PubMed  Europe PubMed DOI
  43. Shahlaei,M., Sabet,R., Ziari,M.B., Moeinifard,B., Fassihi,A. and Karbakhsh,R.
    QSAR study of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2 using LS-SVM and GRNN based on principal components
    Eur J Med Chem (2010) 45, 4499-4508. PubMed  Europe PubMed DOI  I
    44. 2009
  44. Alvarado,J.J., Nemkal,A., Sauder,J.M., Russell,M., Akiyoshi,D.E., Shi,W., Almo,S.C. and Weiss,L.M.
    Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470
    Mol Biochem Parasitol (2009) 168, 158-167. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  45. Arico-Muendel,C.C., Benjamin,D.R., Caiazzo,T.M., Centrella,P.A., Contonio,B.D., Cook,C.M., Doyle,E.G., Hannig,G., Labenski,M.T., Searle,L.L., Lind,K., Morgan,B.A., Olson,G., Paradise,C.L., Self,C., Skinner,S.R., Sluboski,B., Svendsen,J.L., Thompson,C.D., Westlin,W. and White,K.F.
    Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2
    J Med Chem (2009) 52, 8047-8056. PubMed  Europe PubMed DOI  I
  46. Chen,X., Xie,S., Bhat,S., Kumar,N., Shapiro,T.A. and Liu,J.O.
    Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo
    Chem Biol (2009) 16, 193-202. PubMed  Europe PubMed DOI  I
    47. 2008
  47. Lazarus,D.D., Doyle,E.G., Bernier,S.G., Rogers,A.B., Labenski,M.T., Wakefield,J.D., Karp,R.M., Clark,E.J., Lorusso,J., Hoyt,J.G., Thompson,C.D., Hannig,G. and Westlin,W.F.
    An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis
    Inflamm Res (2008) 57, 18-27. PubMed  Europe PubMed DOI  I
  48. Tucker,L.A., Zhang,Q., Sheppard,G.S., Lou,P., Jiang,F., McKeegan,E., Lesniewski,R., Davidsen,S.K., Bell,R.L. and Wang,J.
    Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation
    Oncogene (2008) 27, 3967-3976. PubMed  Europe PubMed DOI
  49. Warder,S.E., Tucker,L.A., McLoughlin,S.M., Strelitzer,T.J., Meuth,J.L., Zhang,Q., Sheppard,G.S., Richardson,P.L., Lesniewski,R., Davidsen,S.K., Bell,R.L., Rogers,J.C. and Wang,J.
    Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition
    J Proteome Res (2008) 7, 4807-4820. PubMed  Europe PubMed DOI  P
    50. 2007
  50. Bainbridge,J., Madden,L., Essex,D., Binks,M., Malhotra,R. and Paleolog,E.M.
    Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition
    Arthritis Res Ther (2007) 9, R127-R127. PubMed  Europe PubMed DOI  PMC  EPMC  I
  51. Kass,D., Bridges,R.S., Borczuk,A. and Greenberg,S.
    Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis
    Am J Respir Cell Mol Biol (2007) 37, 193-201. PubMed  Europe PubMed DOI  T
  52. Marino,J.P., Jr., Fisher,P.W., Hofmann,G.A., Kirkpatrick,R.B., Janson,C.A., Johnson,R.K., Ma,C., Mattern,M., Meek,T.D., Ryan,M.D., Schulz,C., Smith,W.W., Tew,D.G., Tomazek,T.A., Jr., Veber,D.F., Xiong,W.C., Yamamoto,Y., Yamashita,K., Yang,G. and Thompson,S.K.
    Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore
    J Med Chem (2007) 50, 3777-3785. PubMed  Europe PubMed DOI  S  I
  53. Noguchi,S., Komiya,T., Eguchi,H., Shirahata,A., Nikawa,J. and Kawamura,M.
    Methionine aminopeptidase II: a molecular chaperone for sarcoplasmic reticulum calcium ATPase
    J Membr Biol (2007) 215, 105-110. PubMed  Europe PubMed DOI
  54. Sawanyawisuth,K., Wongkham,C., Pairojkul,C., Saeseow,O.T., Riggins,G.J., Araki,N. and Wongkham,S.
    Methionine aminopeptidase 2 over-expressed in cholangiocarcinoma: potential for drug target
    Acta Oncol (2007) 46, 378-385. PubMed  Europe PubMed DOI  T
  55. Wang,G.T., Mantei,R.A., Kawai,M., Tedrow,J.S., Barnes,D.M., Wang,J., Zhang,Q., Lou,P., Garcia,L.A., Bouska,J., Yates,M., Park,C., Judge,R.A., Lesniewski,R., Sheppard,G.S. and Bell,R.L.
    Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids
    Bioorg Med Chem Lett (2007) 17, 2817-2822. PubMed  Europe PubMed DOI  I
    56. 2006
  56. Hu,X., Addlagatta,A., Matthews,B.W. and Liu,J.O.
    Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases
    Angew Chem Int Ed Engl (2006) 45, 3772-3775. PubMed  Europe PubMed DOI  S  I
  57. Selvakumar,P., Lakshmikuttyamma,A., Dimmock,J.R. and Sharma,R.K.
    Methionine aminopeptidase 2 and cancer
    Biochim Biophys Acta (2006) 1765, 148-154. PubMed  Europe PubMed DOI
  58. [YEAR:17-8-2006]Upadhya,R., Zhang,H.S. and Weiss,L.M.
    System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiae
    Antimicrob Agents Chemother (17-8-2006) 50, 3389-3395. PubMed  Europe PubMed DOI  E
    59. 2005
  59. Addlagatta,A., Hu,X., Liu,J.O. and Matthews,B.W.
    Structural basis for the functional differences between type I and type II human methionine aminopeptidases
    Biochemistry (2005) 44, 14741-14749. PubMed  Europe PubMed DOI  S  I
  60. [YEAR:10-3-2005]Chun,E., Han,C.K., Yoon,J.H., Sim,T.B., Kim,Y.K. and Lee,K.Y.
    Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model
    Int J Cancer (10-3-2005) 114, 124-130. PubMed  Europe PubMed DOI  I
  61. [YEAR:1-3-2005]Vetro,J.A., Dummitt,B., Micka,W.S. and Chang,Y.H.
    Evidence of a dominant negative mutant of yeast methionine aminopeptidase type 2 in Saccharomyces cerevisiae
    J Cell Biochem (1-3-2005) 94, 656-668. PubMed  Europe PubMed DOI
    62. 2004
  62. [YEAR:9-8-2004]Asami,Y., Kakeya,H., Onose,R., Chang,Y.H., Toi,M. and Osada,H.
    RK-805, an endothelial-cell-growth inhibitor produced by Neosartorya sp., and a docking model with methionine aminopeptidase-2
    Tetrahedron (9-8-2004) 60, 7085-7091. DOI  I
  63. [YEAR:8-10-2004]Boxem,M., Tsai,C.W., Zhang,Y., Saito,R.M. and Liu,J.O.
    The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation
    FEBS Lett (8-10-2004) 576, 245-250. PubMed  Europe PubMed DOI  K  I
  64. Bradshaw,R.A., Yi,E. and Walker,K.W.
    Methionyl aminopeptidase type II
    [ISSN:0-12-079610-4] (2004) 2, 917-922.  V
  65. [YEAR:5-3-2004]Brdlik,C.M. and Crews,C.M.
    A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases
    J Biol Chem (5-3-2004) 279, 9475-9480. PubMed  Europe PubMed DOI  PMC  EPMC  I
  66. Giglione,C., Boularot,A. and Meinnel,T.
    Protein N-terminal methionine excision
    Cell Mol Life Sci (2004) 61, 1455-1474. PubMed  Europe PubMed DOI
  67. [YEAR:5-1-2004]Hu,X., Zhu,J., Srivathsan,S. and Pei,D.
    Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors
    Bioorg Med Chem Lett (5-1-2004) 14, 77-79. PubMed  Europe PubMed DOI  I
  68. [YEAR:1-5-2004]Kim,S., LaMontagne,K., Sabio,M., Sharma,S., Versace,R.W., Yusuff,N. and Phillips,P.E.
    Depletion of methionine aminopeptidase 2 does not alter cell response to fumagillin or bengamides
    Cancer Res (1-5-2004) 64, 2984-2987. PubMed  Europe PubMed DOI  I
  69. [YEAR:15-11-2004]Nakagawa,H., Koyanagi,S., Takiguchi,T., Kuramoto,Y., Soeda,S., Shimeno,H., Higuchi,S. and Ohdo,S.
    24-hour oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression, is regulated by clock gene proteins
    Cancer Res (15-11-2004) 64, 8328-8333. PubMed  Europe PubMed DOI
  70. [YEAR:23-2-2004]Sheppard,G.S., Wang,J., Kawai,M., BaMaung,N.Y., Craig,R.A., Erickson,S.A., Lynch,L., Patel,J., Yang,F., Searle,X.B., Lou,P., Park,C., Kim,K.H., Henkin,J. and Lesniewski,R.
    3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2
    Bioorg Med Chem Lett (23-2-2004) 14, 865-868. PubMed  Europe PubMed DOI  I
    71. 2003
  71. [YEAR:26-12-2003]Towbin,H., Bair,K.W., DeCaprio,J.A., Eck,M.J., Kim,S., Kinder,F.R., Morollo,A., Mueller,D.R., Schindler,P., Song,H.K., van Oostrum,J., Versace,R.W., Voshol,H., Wood,J., Zabludoff,S. and Phillips,P.E.
    Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors
    J Biol Chem (26-12-2003) 278, 52964-52971. PubMed  Europe PubMed DOI  I
  72. [YEAR:6-5-2003]Wang,J., Sheppard,G.S., Lou,P., Kawai,M., Park,C., Egan,D.A., Schneider,A., Bouska,J., Lesniewski,R. and Henkin,J.
    Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese
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