$VAR1 = undef;

Summary for peptidase M24.002: methionyl aminopeptidase 2

Names
MEROPS Name	methionyl aminopeptidase 2
Other names	eukaryotic initiation factor 2 alpha binding protein p67, methionine aminopeptidase 2, peptidase M, MetAP2 (Saccharomyces cerevisiae)

Domain architecture

MEROPS Classification
Classification	Clan MG >> Subclan (none) >> Family M24 >> Subfamily A >> M24.002
Holotype	methionyl aminopeptidase 2 (Homo sapiens), Uniprot accession P50579 (peptidase unit: 156-478), MERNUM MER0001728
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00237
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.18
Enzymology	BRENDA database
Activity status	human: active (Bradshaw et al., 2004) mouse: active (Turk et al., 1998)
Physiology	Probable role in cotranslational removal of N-terminal methionine in protein synthesis.
Pharmaceutical relevance	Target of drugs inhibiting angiogenesis, and the primary target of the potent angiogenesis inhibitors fumagillin and ovalicin (Endo et al., 2002). A rationally-designed reversible inhibitor suppressed the growth of several tumours (Wang et al., 2003).
Other databases	TREEFAM	http://www.treefam.org/family/TF300426
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/Masvpt/-/-/- (based on 135 cleavages)

Specificity matrix

Amino acid	P1	P1'	P2'	P3'	P4'
Gly	0	7	3	5	2
Pro	0	19	4	2	9
Ala	0	41	2	4	5
Val	0	25	10	17	8
Leu	0	0	5	10	12
Ile	0	0	6	7	8
Met	135	1	1	1	0
Phe	0	0	2	5	2
Tyr	0	0	4	9	6
Trp	0	0	2	2	0
Ser	0	27	8	8	5
Thr	0	15	13	11	14
Cys	0	0	0	0	0
Asn	0	0	6	6	8
Gln	0	0	1	7	2
Asp	0	0	10	2	9
Glu	0	0	26	17	19
Lys	0	0	23	13	18
Arg	0	0	7	7	4
His	0	0	1	1	3