$VAR1 = undef;

Summary for peptidase M18.002: aspartyl aminopeptidase

Names
MEROPS Name	aspartyl aminopeptidase
Other names	Ape4 g.p. (Saccharomyces cerevisiae), DNPEP g.p. (Homo sapiens), aspartic aminopeptidase

Domain architecture

MEROPS Classification
Classification	Clan MH >> Subclan (none) >> Family M18 >> Subfamily (none) >> M18.002
Holotype	aspartyl aminopeptidase (Mus musculus), Uniprot accession Q9Z2W0 (peptidase unit: 9-473), MERNUM MER0003374
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00227
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.21
Enzymology	BRENDA database
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Wilk, 2004) mouse: active (by similarity to human) (Wilk et al., 1998)
Other databases	TREEFAM	http://www.treefam.org/family/TF300487
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/D-/-/-/- (based on 10 cleavages)

Specificity matrix

Amino acid	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	0
Pro	0	0	1	0	0
Ala	0	2	0	0	0
Val	0	0	1	0	0
Leu	0	1	0	0	0
Ile	0	0	0	0	1
Met	0	0	0	0	0
Phe	0	1	1	0	0
Tyr	0	0	0	1	0
Trp	0	0	0	0	1
Ser	0	1	0	0	0
Thr	0	0	0	0	0
Cys	0	0	0	0	0
Asn	0	0	0	0	0
Gln	0	0	0	0	0
Asp	8	0	0	0	0
Glu	2	0	0	0	0
Lys	0	0	0	0	0
Arg	0	1	0	1	0
His	0	2	0	0	0