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Literature for peptidase M18.002: aspartyl aminopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Zhou,C., Yang,F., Li,C., Mao,H., Wang,K., Shang,J., Gao,X. and He,W.
    Detection of aspartyl aminopeptidase in atherosclerosis mice and clinical sample using an optical probe
    Mater Today Bio (2025) 35, 102391-102391. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2020
  2. Kakodkar,P., More,S., Andras,K., Papakonstantinou,N., Kelly,S., Makrooni,M.A., Ortutay,C. and Szegezdi,E.
    Aspartic Aminopeptidase Is a Novel Biomarker of Aggressive Chronic Lymphocytic Leukemia
    Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI
  3. Ramirez-Exposito,M.J., Carrera-Gonzalez,M.P. and Martinez-Martos,J.M.
    Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas
    Brain Res Bull (2020) 168, 1-7. PubMed  Europe PubMed DOI
  4. Seco-Calvo,J., Sanchez-Herraez,S., Casis,L., Valdivia,A., Perez-Urzelai,I., Gil,J. and Echevarria,E.
    Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
    Bone Joint Res (2020) 9, 789-797. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2019
  5. Geng,N., Zhang,W., Li,Y. and Li,F.
    Aspartyl aminopeptidase suppresses proliferation, invasion, and stemness of breast cancer cells via targeting CD44
    Anat Rec (Hoboken) (2019) 302, 2178-2185. PubMed  Europe PubMed DOI
    6. 2018
  6. Gao,X., Yin,Y. and Zhou,C.
    Purification, characterisation and salt-tolerance molecular mechanisms of aspartyl aminopeptidase from Aspergillus oryzae 3.042
    Food Chem (2018) 240, 377-385. PubMed  Europe PubMed DOI
    7. 2017
  7. Alrahman,M.A. and Yoon,S.S.
    Identification of essential genes of Pseudomonas aeruginosa for its growth in airway mucus
    J Microbiol (2017) 55, 68-74. PubMed  Europe PubMed DOI
  8. Gontijo,F.A., de Melo,A.T., Pascon,R.C., Fernandes,L., Paes,H.C., Alspaugh,J.A. and Vallim,M.A.
    The role of aspartyl aminopeptidase (Ape4) in Cryptococcus neoformans virulence and authophagy
    PLoS ONE (2017) 12, e0177461-e0177461. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Koumangoye,R. and Delpire,E.
    DNPEP is not the only peptidase that produces SPAK fragments in kidney
    Physiol Rep (2017) 5 PubMed  Europe PubMed DOI
    10. 2015
  10. Lee,A., Slattery,C., Nikolic-Paterson,D.J., Hryciw,D.H., Wilk,S., Wilk,E., Zhang,Y., Valova,V.A., Robinson,P.J., Kelly,D.J. and Poronnik,P.
    Chloride channel ClC-5 binds to aspartyl aminopeptidase to regulate renal albumin endocytosis
    Am J Physiol Renal Physiol (2015) 308, F784-F792. PubMed  Europe PubMed DOI
    11. 2014
  11. Chen,Y., Tang,H., Seibel,W., Papoian,R., Oh,K., Li,X., Zhang,J., Golczak,M., Palczewski,K. and Kiser,P.D.
    Identification and characterization of novel inhibitors of mammalian aspartyl aminopeptidase
    Mol Pharmacol (2014) 86, 231-242. PubMed  Europe PubMed DOI  I
  12. Markadieu,N., Rios,K., Spiller,B.W., McDonald,W.H., Welling,P.A. and Delpire,E.
    Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage
    J Biol Chem (2014) 289, 29273-29284. PubMed  Europe PubMed DOI  P
  13. Nguyen,D.D., Pandian,R., Kim,D., Ha,S.C., Yoon,H.J., Kim,K.S., Yun,K.H., Kim,J.H. and Kim,K.K.
    Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa
    Biochem Biophys Res Commun (2014) 447, 101-107. PubMed  Europe PubMed DOI  S
    14. 2013
  14. Li,X., Chen,B., Yoshina,S., Cai,T., Yang,F., Mitani,S. and Wang,X.
    Inactivation of Caenorhabditis elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants
    Mol Biol Cell (2013) 24, 1163-1175. PubMed  Europe PubMed DOI
    15. 2012
  15. Chaikuad,A., Pilka,E.S., De Riso,A., von Delft,F., Kavanagh,K.L., Venien-Bryan,C., Oppermann,U. and Yue,W.W.
    Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family
    BMC Struct Biol (2012) 12, 14-14. PubMed  Europe PubMed DOI
  16. Chen,Y., Farquhar,E.R., Chance,M.R., Palczewski,K. and Kiser,P.D.
    Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase
    J Biol Chem (2012) 287, 13356-13370. PubMed  Europe PubMed DOI  P  S
  17. Wilk,S.
    Aspartyl aminopeptidase
    [ISSN:978-0-12-407743-0] (2012) 3, 1570-1573. DOI
    18. 2011
  18. Yuga,M., Gomi,K., Klionsky,D.J. and Shintani,T.
    Aspartyl aminopeptidase is imported from the cytoplasm to the vacuole by selective autophagy in Saccharomyces cerevisiae
    J Biol Chem (2011) 286, 13704-13713. PubMed  Europe PubMed DOI
    19. 2010
  19. Cai,W.W., Wang,L. and Chen,Y.
    Aspartyl aminopeptidase, encoded by an evolutionarily conserved syntenic gene, is colocalized with its cluster in secretory granules of pancreatic islet cells
    Biosci Biotechnol Biochem (2010) 74, 2050-2055. PubMed  Europe PubMed DOI
    20. 2009
  20. Lee,S., Kim,J.S., Yun,C.H., Chae,H.Z. and Kim,K.
    Aspartyl aminopeptidase of Schizosaccharomyces pombe has a molecular chaperone function
    BMB Rep (2009) 42, 812-816. PubMed  Europe PubMed
    21. 2008
  21. Kusumoto,K.I., Matsushita-Morita,M., Furukawa,I., Suzuki,S., Yamagata,Y., Koide,Y., Ishida,H., Takeuchi,M. and Kashiwagi,Y.
    Efficient production and partial characterization of aspartyl aminopeptidase from Aspergillus oryzae
    J Appl Microbiol (2008) 105, 1711-1719. PubMed  Europe PubMed DOI  E
    22. 2007
  22. Watanabe,J., Tanaka,H., Akagawa,T., Mogi,Y. and Yamazaki,T.
    Characterization of Aspergillus oryzae aspartyl aminopeptidase expressed in Escherichia coli
    Biosci Biotechnol Biochem (2007) 71, 2557-2560. PubMed  Europe PubMed DOI  E
    23. 2006
  23. Yokoyama,R., Kawasaki,H. and Hirano,H.
    Identification of yeast aspartyl aminopeptidase gene by purifying and characterizing its product from yeast cells
    FEBS J (2006) 273, 192-198. PubMed  Europe PubMed DOI
    24. 2004
  24. Wilk,S.
    Aspartyl aminopeptidase
    [ISSN:0-12-079610-4] (2004) 2, 937-939.  V
    25. 2002
  25. [YEAR:15-11-2002]Wilk,S., Wilk,E. and Magnusson,R.P.
    Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase
    Arch Biochem Biophys (15-11-2002) 407, 176-183. PubMed  Europe PubMed DOI
    26. 1998
  26. [YEAR:26-6-1998]Wilk,S., Wilk,E. and Magnusson,R.P.
    Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase
    J Biol Chem (26-6-1998) 273, 15961-15970. PubMed  Europe PubMed DOI
    27. 1983
  27. Kelly,J.A., Neidle,E.L. and Neidle,A.
    An aminopeptidase from mouse brain cytosol that cleaves N-terminal acidic amino acid residues
    J Neurochem (1983) 40, 1727-1734. PubMed  Europe PubMed
    28. 1971
  28. [YEAR:21-7-1971]Cheung,H.S. and Cushman,D.W.
    A soluble aspartate aminopeptidase from dog kidney
    Biochim Biophys Acta (21-7-1971) 242, 190-193. PubMed  Europe PubMed

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