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Literature for peptidase M18.002: aspartyl aminopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Zhou,C., Yang,F., Li,C., Mao,H., Wang,K., Shang,J., Gao,X. and He,W.<br>Detection of aspartyl aminopeptidase in atherosclerosis mice and clinical sample using an optical probe<br>Mater Today Bio (2025) 35, 102391-102391. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2020
  2. Kakodkar,P., More,S., Andras,K., Papakonstantinou,N., Kelly,S., Makrooni,M.A., Ortutay,C. and Szegezdi,E.<br>Aspartic Aminopeptidase Is a Novel Biomarker of Aggressive Chronic Lymphocytic Leukemia<br>Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI
  3. Ramirez-Exposito,M.J., Carrera-Gonzalez,M.P. and Martinez-Martos,J.M.<br>Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas<br>Brain Res Bull (2020) 168, 1-7. PubMed  Europe PubMed DOI
  4. Seco-Calvo,J., Sanchez-Herraez,S., Casis,L., Valdivia,A., Perez-Urzelai,I., Gil,J. and Echevarria,E.<br>Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression<br>Bone Joint Res (2020) 9, 789-797. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2019
  5. Geng,N., Zhang,W., Li,Y. and Li,F.<br>Aspartyl aminopeptidase suppresses proliferation, invasion, and stemness of breast cancer cells via targeting CD44<br>Anat Rec (Hoboken) (2019) 302, 2178-2185. PubMed  Europe PubMed DOI
    6. 2018
  6. Gao,X., Yin,Y. and Zhou,C.<br>Purification, characterisation and salt-tolerance molecular mechanisms of aspartyl aminopeptidase from Aspergillus oryzae 3.042<br>Food Chem (2018) 240, 377-385. PubMed  Europe PubMed DOI
    7. 2017
  7. Alrahman,M.A. and Yoon,S.S.<br>Identification of essential genes of Pseudomonas aeruginosa for its growth in airway mucus<br>J Microbiol (2017) 55, 68-74. PubMed  Europe PubMed DOI
  8. Gontijo,F.A., de Melo,A.T., Pascon,R.C., Fernandes,L., Paes,H.C., Alspaugh,J.A. and Vallim,M.A.<br>The role of aspartyl aminopeptidase (Ape4) in Cryptococcus neoformans virulence and authophagy<br>PLoS ONE (2017) 12, e0177461-e0177461. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Koumangoye,R. and Delpire,E.<br>DNPEP is not the only peptidase that produces SPAK fragments in kidney<br>Physiol Rep (2017) 5 PubMed  Europe PubMed DOI
    10. 2015
  10. Lee,A., Slattery,C., Nikolic-Paterson,D.J., Hryciw,D.H., Wilk,S., Wilk,E., Zhang,Y., Valova,V.A., Robinson,P.J., Kelly,D.J. and Poronnik,P.<br>Chloride channel ClC-5 binds to aspartyl aminopeptidase to regulate renal albumin endocytosis<br>Am J Physiol Renal Physiol (2015) 308, F784-F792. PubMed  Europe PubMed DOI
    11. 2014
  11. Chen,Y., Tang,H., Seibel,W., Papoian,R., Oh,K., Li,X., Zhang,J., Golczak,M., Palczewski,K. and Kiser,P.D.<br>Identification and characterization of novel inhibitors of mammalian aspartyl aminopeptidase<br>Mol Pharmacol (2014) 86, 231-242. PubMed  Europe PubMed DOI  I
  12. Markadieu,N., Rios,K., Spiller,B.W., McDonald,W.H., Welling,P.A. and Delpire,E.<br>Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage<br>J Biol Chem (2014) 289, 29273-29284. PubMed  Europe PubMed DOI  P
  13. Nguyen,D.D., Pandian,R., Kim,D., Ha,S.C., Yoon,H.J., Kim,K.S., Yun,K.H., Kim,J.H. and Kim,K.K.<br>Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa<br>Biochem Biophys Res Commun (2014) 447, 101-107. PubMed  Europe PubMed DOI  S
    14. 2013
  14. Li,X., Chen,B., Yoshina,S., Cai,T., Yang,F., Mitani,S. and Wang,X.<br>Inactivation of Caenorhabditis elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants<br>Mol Biol Cell (2013) 24, 1163-1175. PubMed  Europe PubMed DOI
    15. 2012
  15. Chaikuad,A., Pilka,E.S., De Riso,A., von Delft,F., Kavanagh,K.L., Venien-Bryan,C., Oppermann,U. and Yue,W.W.<br>Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family<br>BMC Struct Biol (2012) 12, 14-14. PubMed  Europe PubMed DOI
  16. Chen,Y., Farquhar,E.R., Chance,M.R., Palczewski,K. and Kiser,P.D.<br>Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase<br>J Biol Chem (2012) 287, 13356-13370. PubMed  Europe PubMed DOI  P  S
  17. Wilk,S.<br>Aspartyl aminopeptidase<br>[ISSN:978-0-12-407743-0] (2012) 3, 1570-1573. DOI
    18. 2011
  18. Yuga,M., Gomi,K., Klionsky,D.J. and Shintani,T.<br>Aspartyl aminopeptidase is imported from the cytoplasm to the vacuole by selective autophagy in Saccharomyces cerevisiae<br>J Biol Chem (2011) 286, 13704-13713. PubMed  Europe PubMed DOI
    19. 2010
  19. Cai,W.W., Wang,L. and Chen,Y.<br>Aspartyl aminopeptidase, encoded by an evolutionarily conserved syntenic gene, is colocalized with its cluster in secretory granules of pancreatic islet cells<br>Biosci Biotechnol Biochem (2010) 74, 2050-2055. PubMed  Europe PubMed DOI
    20. 2009
  20. Lee,S., Kim,J.S., Yun,C.H., Chae,H.Z. and Kim,K.<br>Aspartyl aminopeptidase of Schizosaccharomyces pombe has a molecular chaperone function<br>BMB Rep (2009) 42, 812-816. PubMed  Europe PubMed
    21. 2008
  21. Kusumoto,K.I., Matsushita-Morita,M., Furukawa,I., Suzuki,S., Yamagata,Y., Koide,Y., Ishida,H., Takeuchi,M. and Kashiwagi,Y.<br>Efficient production and partial characterization of aspartyl aminopeptidase from Aspergillus oryzae<br>J Appl Microbiol (2008) 105, 1711-1719. PubMed  Europe PubMed DOI  E
    22. 2007
  22. Watanabe,J., Tanaka,H., Akagawa,T., Mogi,Y. and Yamazaki,T.<br>Characterization of Aspergillus oryzae aspartyl aminopeptidase expressed in Escherichia coli<br>Biosci Biotechnol Biochem (2007) 71, 2557-2560. PubMed  Europe PubMed DOI  E
    23. 2006
  23. Yokoyama,R., Kawasaki,H. and Hirano,H.<br>Identification of yeast aspartyl aminopeptidase gene by purifying and characterizing its product from yeast cells<br>FEBS J (2006) 273, 192-198. PubMed  Europe PubMed DOI
    24. 2004
  24. Wilk,S.<br>Aspartyl aminopeptidase<br>[ISSN:0-12-079610-4] (2004) 2, 937-939.  V
    25. 2002
  25. [YEAR:15-11-2002]Wilk,S., Wilk,E. and Magnusson,R.P.<br>Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase<br>Arch Biochem Biophys (15-11-2002) 407, 176-183. PubMed  Europe PubMed DOI
    26. 1998
  26. [YEAR:26-6-1998]Wilk,S., Wilk,E. and Magnusson,R.P.<br>Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase<br>J Biol Chem (26-6-1998) 273, 15961-15970. PubMed  Europe PubMed DOI
    27. 1983
  27. Kelly,J.A., Neidle,E.L. and Neidle,A.<br>An aminopeptidase from mouse brain cytosol that cleaves N-terminal acidic amino acid residues<br>J Neurochem (1983) 40, 1727-1734. PubMed  Europe PubMed
    28. 1971
  28. [YEAR:21-7-1971]Cheung,H.S. and Cushman,D.W.<br>A soluble aspartate aminopeptidase from dog kidney<br>Biochim Biophys Acta (21-7-1971) 242, 190-193. PubMed  Europe PubMed

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