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Literature for peptidase M12.222: ADAMTS1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, I Inhibitor, P Specificity, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Kim,J.H., Lee,S.H., Kim,S.Y., Kim,J.W., Jeong,J.S., Chung,E.H., Lee,S.H., Kim,C.Y., Choi,B.K., Ko,J.W. and Kim,T.W.
    Recombinant ADAMTSƒ_'1 promotes muscle regeneration accompanied by downregulation of Notch signaling
    Int J Mol Med (2026) 57 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Martin,D.R., Sardelli,G., Burkhard,T., Fowkes,M.M., Minns,A.F., Moschini,R., Del Corso,A., de Groot,R., Apte,S.S. and Santamaria,S.
    Characterization of ADAMTS9 proteoglycanase activity: comparison with ADAMTS1, ADAMTS4 and ADAMTS5
    J Biol Chem (2025) , 110301-110301. PubMed  Europe PubMed DOI
    3. 2024
  3. Burkhard,T., Minns,A.F. and Santamaria,S.
    Expression and Purification of Recombinant ADAMTS8
    Methods Mol Biol (2024) 2747, 55-66. PubMed  Europe PubMed DOI
  4. Lin,Y., Yang,Q., Lin,X., Liu,X., Qian,Y., Xu,D., Cao,N., Han,X., Zhu,Y., Hu,W., He,X., Yu,Z., Kong,X., Zhu,L., Zhong,Z., Liu,K., Zhou,B., Wang,Y., Peng,J., Zhu,W. and Wang,J.
    Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation
    Circulation (2024) 149, 605-626. PubMed  Europe PubMed DOI
  5. Pietrzak,J., Swiechowski,R., Wosiak,A., Wcislo,S. and Balcerczak,E.
    ADAMTS Gene-Derived circRNA Molecules in Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations and Survival Analysis
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Silva,S.V., Lima,M.A., Hodgson,L., Freitas,V.M. and Rodriguez-Manzaneque,J.C.
    ADAMTS-1 has nuclear localization in cells with epithelial origin and leads to decreased cell migration
    Exp Cell Res (2023) 433, 113852-113852. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2022
  7. Inagaki,J., Nakano,A., Hatipoglu,O.F., Ooka,Y., Tani,Y., Miki,A., Ikemura,K., Opoku,G., Ando,R., Kodama,S., Ohtsuki,T., Yamaji,H., Yamamoto,S., Katsuyama,E., Watanabe,S. and Hirohata,S.
    Potential of a Novel Chemical Compound Targeting Matrix Metalloprotease-13 for Early Osteoarthritis: An In Vitro Study
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  8. Rosell-Garcia,T., Rivas-Munoz,S., Colige,A. and Rodriguez-Pascual,F.
    Cleavage of LOXL1 by BMP1 and ADAMTS14 Proteases Suggests a Role for Proteolytic Processing in the Regulation of LOXL1 Function
    Int J Mol Sci (2022) 23, 3285-3285. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Tayman,M.A. and Koyuncu,I.
    Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis
    Biotech Histochem (2022) , 1-6. PubMed  Europe PubMed DOI
    10. 2021
  10. Martin,D.R., Santamaria,S., Koch,C.D., Ahnstrom,J. and Apte,S.S.
    Identification of novel ADAMTS1, ADAMTS4 and ADAMTS5 cleavage sites in versican using a label-free quantitative proteomics approach
    J Proteomics (2021) 249, 104358-104358. PubMed  Europe PubMed DOI
  11. Mohamedi,Y., Fontanil,T., Cal,S., Cobo,T. and Obaya,A.J.
    ADAMTS-12: Functions and Challenges for a Complex Metalloprotease
    Front Mol Biosci (2021) 8, 686763-686763. PubMed  Europe PubMed DOI  PMC  EPMC  V
    12. 2020
  12. de Assis Lima,M., da Silva,S.V., Serrano-Garrido,O., Hulsemann,M., Santos-Neres,L., Rodriguez-Manzaneque,J.C., Hodgson,L. and Freitas,V.M.
    Metalloprotease ADAMTS-1 decreases cell migration and invasion modulating the spatiotemporal dynamics of Cdc42 activity
    Cell Signal (2020) 77, 109827-109827. PubMed  Europe PubMed DOI
  13. Lambert,J., Makin,K., Akbareian,S., Johnson,R., Alghamdi,A.A.A., Robinson,S.D. and Edwards,D.R.
    ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis
    J Cell Sci (2020) 133 PubMed  Europe PubMed DOI
  14. Peris-Torres,C., Serrano,O., Plaza-Calonge,M.D.C. and Rodriguez-Manzaneque,J.C.
    Inhibition of ADAMTS1 expression by lentiviral CRISPR/Cas9 gene editing technology
    Methods Mol Biol (2020) 2043, 13-24. PubMed  Europe PubMed DOI  K
  15. Peris-Torres,C., Plaza-Calonge,M.D.C., Lopez-Dominguez,R., Dominguez-Garcia,S., Barrientos-Duran,A., Carmona-Saez,P. and Rodriguez-Manzaneque,J.C.
    Extracellular protease ADAMTS1 is required at early stages of human uveal melanoma development by inducing stemness and endothelial-like features on tumor cells
    Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI
    16. 2019
  16. Santamaria,S., Yamamoto,K., Teraz-Orosz,A., Koch,C., Apte,S.S., de Groot,R., Lane,D.A. and Ahnstrom,J.
    Exosites in hypervariable loops of ADAMTS spacer domains control substrate recognition and proteolysis
    Sci Rep (2019) 9, 10914-10914. PubMed  Europe PubMed DOI  PMC  EPMC  P
    17. 2018
  17. Rodriguez-Baena,F.J., Redondo-Garcia,S., Peris-Torres,C., Martino-Echarri,E., Fernandez-Rodriguez,R., Plaza-Calonge,M.D.C., Anderson,P. and Rodriguez-Manzaneque,J.C.
    ADAMTS1 protease is required for a balanced immune cell repertoire and tumour inflammatory response
    Sci Rep (2018) 8, 13103-13103. PubMed  Europe PubMed DOI  PMC  EPMC  K
    18. 2017
  18. Hirohata,S., Inagaki,J. and Ohtsuki,T.
    Diverse functions of a disintegrin and metalloproteinase with thrombospondin motif-1
    Yakugaku Zasshi (2017) 137, 811-814. PubMed  Europe PubMed DOI
    19. 2016
  19. Chen,S.Z., Ning,L.F., Xu,X., Jiang,W.Y., Xing,C., Jia,W.P., Chen,X.L., Tang,Q.Q. and Huang,H.Y.
    The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling
    Cell Death Differ (2016) 23, 1778-1791. PubMed  Europe PubMed DOI
  20. Fernandez-Rodriguez,R., Rodriguez-Baena,F.J., Martino-Echarri,E., Peris-Torres,C., Del Carmen Plaza-Calonge,M. and Rodriguez-Manzaneque,J.C.
    Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis
    Oncotarget (2016) 7, 34507-34519. PubMed  Europe PubMed DOI
  21. Heckt,T., Keller,J., Peters,S., Streichert,T., Chalaris,A., Rose-John,S., Mell,B., Joe,B., Amling,M. and Schinke,T.
    Parathyroid hormone induces expression and proteolytic processing of Rankl in primary murine osteoblasts
    Bone (2016) 92, 85-93. PubMed  Europe PubMed DOI
    22. 2015
  22. Lyu,C., Chen,Y., Zhu,M., Jin,X., Liu,P., Zheng,Z., Li,C., Zhu,F., Hu,X., Wang,F., Li,W. and Wang,W.
    [Association of ADAMTS-1 gene polymorphisms with ischemic stroke caused by large artery atherosclerosis]
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2015) 32, 844-848. PubMed  Europe PubMed DOI  M
    23. 2013
  23. de Arao Tan,I., Ricciardelli,C. and Russell,D.L.
    The metalloproteinase ADAMTS1: A comprehensive review of its role in tumorigenic and metastatic pathways
    Int J Cancer (2013) 133, 2263-2276. PubMed  Europe PubMed DOI  V
  24. Martino-Echarri,E., Fernandez-Rodriguez,R., Rodriguez-Baena,F.J., Barrientos-Duran,A., Torres-Collado,A.X., Del Carmen Plaza-Calonge,M., Amador-Cubero,S., Cortes,J., Reynolds,L.E., Hodivala-Dilke,K.M. and Rodriguez-Manzaneque,J.C.
    Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on Nidogen-1 and Nidogen-2
    Int J Cancer (2013) 133, 2315-2324. PubMed  Europe PubMed DOI
    25. 2012
  25. Howell,M.D., Torres-Collado,A.X., Iruela-Arispe,M.L. and Gottschall,P.E.
    Selective decline of synaptic protein levels in the frontal cortex of female mice deficient in the extracellular metalloproteinase ADAMTS1
    PLoS ONE (2012) 7, e47226-e47226. PubMed  Europe PubMed DOI  PMC  EPMC  K
  26. Kuno,K.
    ADAMTS1
    [ISSN:978-0-12-407744-7] (2012) 3, 1156-1161. DOI
    27. 2011
  27. Boerboom,D., Lafond,J.F., Zheng,X., Lapointe,E., Mittaz,L., Boyer,A., Pritchard,M.A., DeMayo,F.J., Mort,J.S., Drolet,R. and Richards,J.S.
    Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla
    Dev Dyn (2011) 240, 1806-1814. PubMed  Europe PubMed DOI  K
  28. Bourd-Boittin,K., Bonnier,D., Leyme,A., Mari,B., Tuffery,P., Samson,M., Ezan,F., Baffet,G. and Theret,N.
    Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta
    Hepatology (2011) 54, 2173-2184. PubMed  Europe PubMed DOI
  29. Ricciardelli,C., Frewin,K.M., Tan,I., Williams,E.D., Opeskin,K., Pritchard,M.A., Ingman,W.V. and Russell,D.L.
    The ADAMTS1 protease gene is required for mammary tumor growth and metastasis
    Am J Pathol (2011) 179, 3075-3085. PubMed  Europe PubMed DOI  K
    30. 2010
  30. Brown,H.M., Robker,R.L. and Russell,D.L.
    Development and hormonal regulation of the ovarian lymphatic vasculature
    Endocrinology (2010) 151, 5446-5455. PubMed  Europe PubMed DOI  K
  31. Brown,H.M., Dunning,K.R., Robker,R.L., Boerboom,D., Pritchard,M., Lane,M. and Russell,D.L.
    ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice
    Biol Reprod (2010) 83, 549-557. PubMed  Europe PubMed DOI
  32. Casal,C., Torres-Collado,A.X., Plaza-Calonge Mdel,C., Martino-Echarri,E., Cajal,S., Rojo,F., Griffioen,A.W. and Rodriguez-Manzaneque,J.C.
    ADAMTS1 contributes to the acquisition of an endothelial-like phenotype in plastic tumor cells
    Cancer Res (2010) 70, 4676-4686. PubMed  Europe PubMed DOI
  33. Esselens,C., Malapeira,J., Colome,N., Casal,C., Rodriguez-Manzaneque,J.C., Canals,F. and Arribas,J.
    The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration
    J Biol Chem (2010) 285, 2463-2473. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2009
  34. Hatipoglu,O.F., Hirohata,S., Cilek,M.Z., Ogawa,H., Miyoshi,T., Obika,M., Demircan,K., Shinohata,R., Kusachi,S. and Ninomiya,Y.
    ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells
    J Biol Chem (2009) 284, 16325-16333. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Lu,X., Wang,Q., Hu,G., Van Poznak,C., Fleisher,M., Reiss,M., Massague,J. and Kang,Y.
    ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis
    Genes Dev (2009) 23, 1882-1894. PubMed  Europe PubMed DOI  PMC  EPMC
    36. 2008
  36. Rocks,N., Paulissen,G., Quesada-Calvo,F., Munaut,C., Gonzalez,M.L., Gueders,M., Hacha,J., Gilles,C., Foidart,J.M., Noel,A. and Cataldo,D.D.
    ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo
    Cancer Res (2008) 68, 9541-9550. PubMed  Europe PubMed DOI
  37. Sabatine,M.S., Ploughman,L., Simonsen,K.L., Iakoubova,O.A., Kirchgessner,T.G., Ranade,K., Tsuchihashi,Z., Zerba,K.E., Long,D.U., Tong,C.H., Packard,C.J., Pfeffer,M.A., Devlin,J.J., Shepherd,J., Campos,H., Sacks,F.M. and Braunwald,E.
    Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy
    Arterioscler Thromb Vasc Biol (2008) 28, 562-567. PubMed  Europe PubMed DOI  M
    38. 2007
  38. Gerhardt,S., Hassall,G., Hawtin,P., McCall,E., Flavell,L., Minshull,C., Hargreaves,D., Ting,A., Pauptit,R.A., Parker,A.E. and Abbott,W.M.
    Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains
    J Mol Biol (2007) 373, 891-902. PubMed  Europe PubMed DOI  S
  39. Rehn,A.P., Birch,M.A., Karlstrom,E., Wendel,M. and Lind,T.
    ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing
    Bone (2007) 41, 231-238. PubMed  Europe PubMed DOI
    40. 2006
  40. Brown,H.M., Dunning,K.R., Robker,R.L., Pritchard,M. and Russell,D.L.
    Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis
    Dev Biol (2006) 300, 699-709. PubMed  Europe PubMed DOI
  41. Cross,A.K., Haddock,G., Stock,C.J., Allan,S., Surr,J., Bunning,R.A., Buttle,D.J. and Woodroofe,M.N.
    ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes
    Brain Res (2006) 1088, 19-30. PubMed  Europe PubMed DOI
  42. Lee,N.V., Sato,M., Annis,D.S., Loo,J.A., Wu,L., Mosher,D.F. and Iruela-Arispe,M.L.
    ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2
    EMBO J (2006) 25, 5270-5283. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Lind,T., Birch,M.A. and McKie,N.
    Purification of an insect derived recombinant human ADAMTS-1 reveals novel gelatin (type I collagen) degrading activities
    Mol Cell Biochem (2006) 281, 95-102. PubMed  Europe PubMed DOI  E
  44. Liu,Y.J., Xu,Y. and Yu,Q.
    Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively
    Oncogene (2006) 25, 2452-2467. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Suga,A., Hikasa,H. and Taira,M.
    Xenopus ADAMTS1 negatively modulates FGF signaling independent of its metalloprotease activity
    Dev Biol (2006) 295, 26-39. PubMed  Europe PubMed DOI
  46. [YEAR:26-4-2006]Torres-Collado,A.X., Kisiel,W., Iruela-Arispe,M.L. and Rodriguez-Manzaneque,J.C.
    ADAMTS1 interacts with, cleaves, and modifies the extracellular location of the matrix inhibitor tissue factor pathway inhibitor-2
    J Biol Chem (26-4-2006) 281, 17827-17837. PubMed  Europe PubMed DOI
    47. 2005
  47. [YEAR:11-11-2005]Jonsson-Rylander,A.C., Nilsson,T., Fritsche-Danielson,R., Hammarstrom,A., Behrendt,M., Andersson,J.O., Lindgren,K., Andersson,A.K., Wallbrandt,P., Rosengren,B., Brodin,P., Thelin,A., Westin,A., Hurt-Camejo,E. and Lee-Sogaard,C.H.
    Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican
    Arterioscler Thromb Vasc Biol (11-11-2005) 25, 180-185. PubMed  Europe PubMed DOI
  48. [YEAR:20-4-2005]Krampert,M., Kuenzle,S., Thai,S.N., Lee,N., Iruela-Arispe,M.L. and Werner,S.
    ADAMTS1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells
    J Biol Chem (20-4-2005) 280, 23844-23852. PubMed  Europe PubMed DOI
  49. Lee,N.V., Rodriguez-Manzaneque,J.C., Thai,S.N., Twal,W.O., Luque,A., Lyons,K.M., Argraves,W.S. and Iruela-Arispe,M.L.
    Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1
    J Biol Chem (2005) 280, 34796-34804. PubMed  Europe PubMed DOI
  50. Little,C.B., Mittaz,L., Belluoccio,D., Rogerson,F.M., Campbell,I.K., Meeker,C.T., Bateman,J.F., Pritchard,M.A. and Fosang,A.J.
    ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo
    Arthritis Rheum (2005) 52, 1461-1472. PubMed  Europe PubMed DOI  K
  51. [YEAR:5-1-2005]Miguel,R.F., Pollak,A. and Lubec,G.
    Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease
    Brain Res Mol Brain Res (5-1-2005) 133, 1-5. PubMed  Europe PubMed DOI
  52. Shozu,M., Minami,N., Yokoyama,H., Inoue,M., Kurihara,H., Matsushima,K. and Kuno,K.
    ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary
    J Mol Endocrinol (2005) 35, 343-355. PubMed  Europe PubMed DOI  K
    53. 2004
  53. Kuno,K.
    ADAMTS1
    [ISSN:0-12-079610-4] (2004) 2, 735-737.  V
  54. Kuno,K., Bannai,K., Hakozaki,M., Matsushima,K. and Hirose,K.
    The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential
    Biochem Biophys Res Commun (2004) 319, 1327-1333. PubMed  Europe PubMed DOI
  55. [YEAR:6-8-2004]Longpre,J.M. and Leduc,R.
    Identification of prodomain determinants involved in ADAMTS-1 biosynthesis
    J Biol Chem (6-8-2004) 279, 33237-33245. PubMed  Europe PubMed DOI
  56. Mittaz,L., Russell,D.L., Wilson,T., Brasted,M., Tkalcevic,J., Salamonsen,L.A., Hertzog,P.J. and Pritchard,M.A.
    Adamts-1 is essential for the development and function of the urogenital system
    Biol Reprod (2004) 70, 1096-1105. PubMed  Europe PubMed DOI
  57. Wachsmuth,L., Bau,B., Fan,Z., Pecht,A., Gerwin,N. and Aigner,T.
    ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta
    J Rheumatol (2004) 31, 315-320. PubMed  Europe PubMed
    58. 2003
  58. Iruela-Arispe,M.L., Carpizo,D. and Luque,A.
    ADAMTS1: a matrix metalloprotease with angioinhibitory properties
    Ann N Y Acad Sci (2003) 995, 183-190. PubMed  Europe PubMed
  59. [YEAR:27-6-2003]Luque,A., Carpizo,D.R. and Iruela-Arispe,M.L.
    ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165
    J Biol Chem (27-6-2003) 278, 23656-23665. PubMed  Europe PubMed DOI
  60. [YEAR:24-10-2003]Russell,D.L., Doyle,K.M., Ochsner,S.A., Sandy,J.D. and Richards,J.S.
    Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation
    J Biol Chem (24-10-2003) 278, 42330-42339. PubMed  Europe PubMed DOI
    61. 2002
  61. [YEAR:26-4-2002]Rodriguez-Manzaneque,J.C., Westling,J., Thai,S.N., Luque,A., Knauper,V., Murphy,G., Sandy,J.D. and Iruela-Arispe,M.L.
    ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors
    Biochem Biophys Res Commun (26-4-2002) 293, 501-508. PubMed  Europe PubMed DOI  I
  62. [YEAR:26-4-2002]Wei,P., Zhao,Y.G., Zhuang,L., Hurst,D.R., Ruben,S. and Sang,Q.X.
    Protein engineering and properties of human metalloproteinase and thrombospondin 1
    Biochem Biophys Res Commun (26-4-2002) 293, 478-488. PubMed  Europe PubMed DOI
  63. Yuan,W., Matthews,R.T., Sandy,J.D. and Gottschall,P.E.
    Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats
    Neuroscience (2002) 114, 1091-1101. PubMed  Europe PubMed DOI
    64. 2001
  64. Masui,T., Hosotani,R., Tsuji,S., Miyamoto,Y., Yasuda,S., Ida,J., Nakajima,S., Kawaguchi,M., Kobayashi,H., Koizumi,M., Toyoda,E., Tulachan,S., Arii,S., Doi,R. and Imamura,M.
    Expression of METH-1 and METH-2 in pancreatic cancer
    Clin Cancer Res (2001) 7, 3437-3443. PubMed  Europe PubMed
  65. [YEAR:20-4-2001]Sandy,J.D., Westling,J., Kenagy,R.D., Iruela-Arispe,M.L., Verscharen,C., Rodriguez-Mazaneque,J.C., Zimmermann,D.R., Lemire,J.M., Fischer,J.W., Wight,T.N. and Clowes,A.W.
    Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4
    J Biol Chem (20-4-2001) 276, 13372-13378. PubMed  Europe PubMed DOI
  66. Tang,B.L.
    ADAMTS: a novel family of extracellular matrix proteases
    Int J Biochem Cell Biol (2001) 33, 33-44. PubMed  Europe PubMed DOI
    67. 2000
  67. Diamantis,I., Luthi,M., Hosli,M. and Reichen,J.
    Cloning of the rat ADAMTS-1 gene and its down regulation in endothelial cells in cirrhotic rats
    Liver (2000) 20, 165-172. PubMed  Europe PubMed DOI
  68. Espey,L.L., Yoshioka,S., Russell,D.L., Robker,R.L., Fujii,S. and Richards,J.S.
    Ovarian expression of a disintegrin and metalloproteinase with thrombospondin motifs during ovulation in the gonadotropin-primed immature rat
    Biol Reprod (2000) 62, 1090-1095. PubMed  Europe PubMed
  69. [YEAR:4-8-2000]Kuno,K., Okada,Y., Kawashima,H., Nakamura,H., Miyasaka,M., Ohno,H. and Matsushima,K.
    ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan
    FEBS Lett (4-8-2000) 478, 241-245. PubMed  Europe PubMed DOI
  70. Miles,R.R., Sluka,J.P., Halladay,D.L., Santerre,R.F., Hale,L.V., Bloem,L., Thirunavukkarasu,K., Galvin,R.J., Hock,J.M. and Onyia,J.E.
    ADAMTS-1: A cellular disintegrin and metalloprotease with thrombospondin motifs is a target for parathyroid hormone in bone
    Endocrinology (2000) 141, 4533-4542. PubMed  Europe PubMed DOI
  71. [YEAR:27-10-2000]Rodriguez-Manzaneque,J.C., Milchanowski,A.B., Dufour,E.K., Leduc,R. and Iruela-Arispe,M.L.
    Characterization of METH-1/ADAMTS1 processing reveals two distinct active forms
    J Biol Chem (27-10-2000) 275, 33471-33479. PubMed  Europe PubMed DOI
  72. Shindo,T., Kurihara,H., Kuno,K., Yokoyama,H., Wada,T., Kurihara,Y., Imai,T., Wang,Y., Ogata,M., Nishimatsu,H., Moriyama,N., Oh-hashi,Y., Morita,H., Ishikawa,T., Nagai,R., Yazaki,Y. and Matsushima,K.
    ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function
    J Clin Invest (2000) 105, 1345-1352. PubMed  Europe PubMed DOI  PMC  EPMC
    73. 1999
  73. [YEAR:25-6-1999]Kuno,K., Terashima,Y. and Matsushima,K.
    ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix
    J Biol Chem (25-6-1999) 274, 18821-18826. PubMed  Europe PubMed DOI
  74. [YEAR:26-2-1999]Tang,B.L. and Hong,W.
    ADAMTS: A novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats
    FEBS Lett (26-2-1999) 445, 223-225. PubMed  Europe PubMed DOI
  75. [YEAR:13-8-1999]Vazquez,F., Hastings,G., Ortega,M.A., Lane,T.F., Oikemus,S., Lombardo,M. and Iruela-Arispe,M.L.
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