Literature for peptidase M12.222: ADAMTS1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, I Inhibitor, P Specificity, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Kim,J.H., Lee,S.H., Kim,S.Y., Kim,J.W., Jeong,J.S., Chung,E.H., Lee,S.H., Kim,C.Y., Choi,B.K., Ko,J.W. and Kim,T.W. Recombinant ADAMTSƒ_'1 promotes muscle regeneration accompanied by downregulation of Notch signaling Int J Mol Med (2026) 57 PubMed Europe PubMed DOI PMC EPMC

2025

Martin,D.R., Sardelli,G., Burkhard,T., Fowkes,M.M., Minns,A.F., Moschini,R., Del Corso,A., de Groot,R., Apte,S.S. and Santamaria,S. Characterization of ADAMTS9 proteoglycanase activity: comparison with ADAMTS1, ADAMTS4 and ADAMTS5 J Biol Chem (2025) , 110301-110301. PubMed Europe PubMed DOI

2024

Burkhard,T., Minns,A.F. and Santamaria,S. Expression and Purification of Recombinant ADAMTS8 Methods Mol Biol (2024) 2747, 55-66. PubMed Europe PubMed DOI
Lin,Y., Yang,Q., Lin,X., Liu,X., Qian,Y., Xu,D., Cao,N., Han,X., Zhu,Y., Hu,W., He,X., Yu,Z., Kong,X., Zhu,L., Zhong,Z., Liu,K., Zhou,B., Wang,Y., Peng,J., Zhu,W. and Wang,J. Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation Circulation (2024) 149, 605-626. PubMed Europe PubMed DOI
Pietrzak,J., Swiechowski,R., Wosiak,A., Wcislo,S. and Balcerczak,E. ADAMTS Gene-Derived circRNA Molecules in Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations and Survival Analysis Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC

2023

Silva,S.V., Lima,M.A., Hodgson,L., Freitas,V.M. and Rodriguez-Manzaneque,J.C. ADAMTS-1 has nuclear localization in cells with epithelial origin and leads to decreased cell migration Exp Cell Res (2023) 433, 113852-113852. PubMed Europe PubMed DOI PMC EPMC

2022

Inagaki,J., Nakano,A., Hatipoglu,O.F., Ooka,Y., Tani,Y., Miki,A., Ikemura,K., Opoku,G., Ando,R., Kodama,S., Ohtsuki,T., Yamaji,H., Yamamoto,S., Katsuyama,E., Watanabe,S. and Hirohata,S. Potential of a Novel Chemical Compound Targeting Matrix Metalloprotease-13 for Early Osteoarthritis: An In Vitro Study Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC
Rosell-Garcia,T., Rivas-Munoz,S., Colige,A. and Rodriguez-Pascual,F. Cleavage of LOXL1 by BMP1 and ADAMTS14 Proteases Suggests a Role for Proteolytic Processing in the Regulation of LOXL1 Function Int J Mol Sci (2022) 23, 3285-3285. PubMed Europe PubMed DOI PMC EPMC
Tayman,M.A. and Koyuncu,I. Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis Biotech Histochem (2022) , 1-6. PubMed Europe PubMed DOI

2021

Martin,D.R., Santamaria,S., Koch,C.D., Ahnstrom,J. and Apte,S.S. Identification of novel ADAMTS1, ADAMTS4 and ADAMTS5 cleavage sites in versican using a label-free quantitative proteomics approach J Proteomics (2021) 249, 104358-104358. PubMed Europe PubMed DOI
Mohamedi,Y., Fontanil,T., Cal,S., Cobo,T. and Obaya,A.J. ADAMTS-12: Functions and Challenges for a Complex Metalloprotease Front Mol Biosci (2021) 8, 686763-686763. PubMed Europe PubMed DOI PMC EPMC V

2020

de Assis Lima,M., da Silva,S.V., Serrano-Garrido,O., Hulsemann,M., Santos-Neres,L., Rodriguez-Manzaneque,J.C., Hodgson,L. and Freitas,V.M. Metalloprotease ADAMTS-1 decreases cell migration and invasion modulating the spatiotemporal dynamics of Cdc42 activity Cell Signal (2020) 77, 109827-109827. PubMed Europe PubMed DOI
Lambert,J., Makin,K., Akbareian,S., Johnson,R., Alghamdi,A.A.A., Robinson,S.D. and Edwards,D.R. ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis J Cell Sci (2020) 133 PubMed Europe PubMed DOI
Peris-Torres,C., Serrano,O., Plaza-Calonge,M.D.C. and Rodriguez-Manzaneque,J.C. Inhibition of ADAMTS1 expression by lentiviral CRISPR/Cas9 gene editing technology Methods Mol Biol (2020) 2043, 13-24. PubMed Europe PubMed DOI K
Peris-Torres,C., Plaza-Calonge,M.D.C., Lopez-Dominguez,R., Dominguez-Garcia,S., Barrientos-Duran,A., Carmona-Saez,P. and Rodriguez-Manzaneque,J.C. Extracellular protease ADAMTS1 is required at early stages of human uveal melanoma development by inducing stemness and endothelial-like features on tumor cells Cancers (Basel) (2020) 12 PubMed Europe PubMed DOI

2019

Santamaria,S., Yamamoto,K., Teraz-Orosz,A., Koch,C., Apte,S.S., de Groot,R., Lane,D.A. and Ahnstrom,J. Exosites in hypervariable loops of ADAMTS spacer domains control substrate recognition and proteolysis Sci Rep (2019) 9, 10914-10914. PubMed Europe PubMed DOI PMC EPMC P

2018

Rodriguez-Baena,F.J., Redondo-Garcia,S., Peris-Torres,C., Martino-Echarri,E., Fernandez-Rodriguez,R., Plaza-Calonge,M.D.C., Anderson,P. and Rodriguez-Manzaneque,J.C. ADAMTS1 protease is required for a balanced immune cell repertoire and tumour inflammatory response Sci Rep (2018) 8, 13103-13103. PubMed Europe PubMed DOI PMC EPMC K

2017

Hirohata,S., Inagaki,J. and Ohtsuki,T. Diverse functions of a disintegrin and metalloproteinase with thrombospondin motif-1 Yakugaku Zasshi (2017) 137, 811-814. PubMed Europe PubMed DOI

2016

Chen,S.Z., Ning,L.F., Xu,X., Jiang,W.Y., Xing,C., Jia,W.P., Chen,X.L., Tang,Q.Q. and Huang,H.Y. The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling Cell Death Differ (2016) 23, 1778-1791. PubMed Europe PubMed DOI
Fernandez-Rodriguez,R., Rodriguez-Baena,F.J., Martino-Echarri,E., Peris-Torres,C., Del Carmen Plaza-Calonge,M. and Rodriguez-Manzaneque,J.C. Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis Oncotarget (2016) 7, 34507-34519. PubMed Europe PubMed DOI
Heckt,T., Keller,J., Peters,S., Streichert,T., Chalaris,A., Rose-John,S., Mell,B., Joe,B., Amling,M. and Schinke,T. Parathyroid hormone induces expression and proteolytic processing of Rankl in primary murine osteoblasts Bone (2016) 92, 85-93. PubMed Europe PubMed DOI

2015

Lyu,C., Chen,Y., Zhu,M., Jin,X., Liu,P., Zheng,Z., Li,C., Zhu,F., Hu,X., Wang,F., Li,W. and Wang,W. [Association of ADAMTS-1 gene polymorphisms with ischemic stroke caused by large artery atherosclerosis] Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2015) 32, 844-848. PubMed Europe PubMed DOI M

2013

de Arao Tan,I., Ricciardelli,C. and Russell,D.L. The metalloproteinase ADAMTS1: A comprehensive review of its role in tumorigenic and metastatic pathways Int J Cancer (2013) 133, 2263-2276. PubMed Europe PubMed DOI V
Martino-Echarri,E., Fernandez-Rodriguez,R., Rodriguez-Baena,F.J., Barrientos-Duran,A., Torres-Collado,A.X., Del Carmen Plaza-Calonge,M., Amador-Cubero,S., Cortes,J., Reynolds,L.E., Hodivala-Dilke,K.M. and Rodriguez-Manzaneque,J.C. Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on Nidogen-1 and Nidogen-2 Int J Cancer (2013) 133, 2315-2324. PubMed Europe PubMed DOI

2012

Howell,M.D., Torres-Collado,A.X., Iruela-Arispe,M.L. and Gottschall,P.E. Selective decline of synaptic protein levels in the frontal cortex of female mice deficient in the extracellular metalloproteinase ADAMTS1 PLoS ONE (2012) 7, e47226-e47226. PubMed Europe PubMed DOI PMC EPMC K
Kuno,K. ADAMTS1 [ISSN:978-0-12-407744-7] (2012) 3, 1156-1161. DOI

2011

Boerboom,D., Lafond,J.F., Zheng,X., Lapointe,E., Mittaz,L., Boyer,A., Pritchard,M.A., DeMayo,F.J., Mort,J.S., Drolet,R. and Richards,J.S. Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla Dev Dyn (2011) 240, 1806-1814. PubMed Europe PubMed DOI K
Bourd-Boittin,K., Bonnier,D., Leyme,A., Mari,B., Tuffery,P., Samson,M., Ezan,F., Baffet,G. and Theret,N. Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta Hepatology (2011) 54, 2173-2184. PubMed Europe PubMed DOI
Ricciardelli,C., Frewin,K.M., Tan,I., Williams,E.D., Opeskin,K., Pritchard,M.A., Ingman,W.V. and Russell,D.L. The ADAMTS1 protease gene is required for mammary tumor growth and metastasis Am J Pathol (2011) 179, 3075-3085. PubMed Europe PubMed DOI K

2010

Brown,H.M., Robker,R.L. and Russell,D.L. Development and hormonal regulation of the ovarian lymphatic vasculature Endocrinology (2010) 151, 5446-5455. PubMed Europe PubMed DOI K
Brown,H.M., Dunning,K.R., Robker,R.L., Boerboom,D., Pritchard,M., Lane,M. and Russell,D.L. ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice Biol Reprod (2010) 83, 549-557. PubMed Europe PubMed DOI
Casal,C., Torres-Collado,A.X., Plaza-Calonge Mdel,C., Martino-Echarri,E., Cajal,S., Rojo,F., Griffioen,A.W. and Rodriguez-Manzaneque,J.C. ADAMTS1 contributes to the acquisition of an endothelial-like phenotype in plastic tumor cells Cancer Res (2010) 70, 4676-4686. PubMed Europe PubMed DOI
Esselens,C., Malapeira,J., Colome,N., Casal,C., Rodriguez-Manzaneque,J.C., Canals,F. and Arribas,J. The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration J Biol Chem (2010) 285, 2463-2473. PubMed Europe PubMed DOI PMC EPMC

2009

Hatipoglu,O.F., Hirohata,S., Cilek,M.Z., Ogawa,H., Miyoshi,T., Obika,M., Demircan,K., Shinohata,R., Kusachi,S. and Ninomiya,Y. ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells J Biol Chem (2009) 284, 16325-16333. PubMed Europe PubMed DOI PMC EPMC
Lu,X., Wang,Q., Hu,G., Van Poznak,C., Fleisher,M., Reiss,M., Massague,J. and Kang,Y. ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis Genes Dev (2009) 23, 1882-1894. PubMed Europe PubMed DOI PMC EPMC

2008

Rocks,N., Paulissen,G., Quesada-Calvo,F., Munaut,C., Gonzalez,M.L., Gueders,M., Hacha,J., Gilles,C., Foidart,J.M., Noel,A. and Cataldo,D.D. ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo Cancer Res (2008) 68, 9541-9550. PubMed Europe PubMed DOI
Sabatine,M.S., Ploughman,L., Simonsen,K.L., Iakoubova,O.A., Kirchgessner,T.G., Ranade,K., Tsuchihashi,Z., Zerba,K.E., Long,D.U., Tong,C.H., Packard,C.J., Pfeffer,M.A., Devlin,J.J., Shepherd,J., Campos,H., Sacks,F.M. and Braunwald,E. Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy Arterioscler Thromb Vasc Biol (2008) 28, 562-567. PubMed Europe PubMed DOI M

2007

Gerhardt,S., Hassall,G., Hawtin,P., McCall,E., Flavell,L., Minshull,C., Hargreaves,D., Ting,A., Pauptit,R.A., Parker,A.E. and Abbott,W.M. Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains J Mol Biol (2007) 373, 891-902. PubMed Europe PubMed DOI S
Rehn,A.P., Birch,M.A., Karlstrom,E., Wendel,M. and Lind,T. ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing Bone (2007) 41, 231-238. PubMed Europe PubMed DOI

2006

Brown,H.M., Dunning,K.R., Robker,R.L., Pritchard,M. and Russell,D.L. Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis Dev Biol (2006) 300, 699-709. PubMed Europe PubMed DOI
Cross,A.K., Haddock,G., Stock,C.J., Allan,S., Surr,J., Bunning,R.A., Buttle,D.J. and Woodroofe,M.N. ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes Brain Res (2006) 1088, 19-30. PubMed Europe PubMed DOI
Lee,N.V., Sato,M., Annis,D.S., Loo,J.A., Wu,L., Mosher,D.F. and Iruela-Arispe,M.L. ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2 EMBO J (2006) 25, 5270-5283. PubMed Europe PubMed DOI PMC EPMC
Lind,T., Birch,M.A. and McKie,N. Purification of an insect derived recombinant human ADAMTS-1 reveals novel gelatin (type I collagen) degrading activities Mol Cell Biochem (2006) 281, 95-102. PubMed Europe PubMed DOI E
Liu,Y.J., Xu,Y. and Yu,Q. Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively Oncogene (2006) 25, 2452-2467. PubMed Europe PubMed DOI PMC EPMC
Suga,A., Hikasa,H. and Taira,M. Xenopus ADAMTS1 negatively modulates FGF signaling independent of its metalloprotease activity Dev Biol (2006) 295, 26-39. PubMed Europe PubMed DOI
[YEAR:26-4-2006]Torres-Collado,A.X., Kisiel,W., Iruela-Arispe,M.L. and Rodriguez-Manzaneque,J.C. ADAMTS1 interacts with, cleaves, and modifies the extracellular location of the matrix inhibitor tissue factor pathway inhibitor-2 J Biol Chem (26-4-2006) 281, 17827-17837. PubMed Europe PubMed DOI

2005

[YEAR:11-11-2005]Jonsson-Rylander,A.C., Nilsson,T., Fritsche-Danielson,R., Hammarstrom,A., Behrendt,M., Andersson,J.O., Lindgren,K., Andersson,A.K., Wallbrandt,P., Rosengren,B., Brodin,P., Thelin,A., Westin,A., Hurt-Camejo,E. and Lee-Sogaard,C.H. Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican Arterioscler Thromb Vasc Biol (11-11-2005) 25, 180-185. PubMed Europe PubMed DOI
[YEAR:20-4-2005]Krampert,M., Kuenzle,S., Thai,S.N., Lee,N., Iruela-Arispe,M.L. and Werner,S. ADAMTS1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells J Biol Chem (20-4-2005) 280, 23844-23852. PubMed Europe PubMed DOI
Lee,N.V., Rodriguez-Manzaneque,J.C., Thai,S.N., Twal,W.O., Luque,A., Lyons,K.M., Argraves,W.S. and Iruela-Arispe,M.L. Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1 J Biol Chem (2005) 280, 34796-34804. PubMed Europe PubMed DOI
Little,C.B., Mittaz,L., Belluoccio,D., Rogerson,F.M., Campbell,I.K., Meeker,C.T., Bateman,J.F., Pritchard,M.A. and Fosang,A.J. ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo Arthritis Rheum (2005) 52, 1461-1472. PubMed Europe PubMed DOI K
[YEAR:5-1-2005]Miguel,R.F., Pollak,A. and Lubec,G. Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease Brain Res Mol Brain Res (5-1-2005) 133, 1-5. PubMed Europe PubMed DOI
Shozu,M., Minami,N., Yokoyama,H., Inoue,M., Kurihara,H., Matsushima,K. and Kuno,K. ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary J Mol Endocrinol (2005) 35, 343-355. PubMed Europe PubMed DOI K

2004

Kuno,K. ADAMTS1 [ISSN:0-12-079610-4] (2004) 2, 735-737. V
Kuno,K., Bannai,K., Hakozaki,M., Matsushima,K. and Hirose,K. The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential Biochem Biophys Res Commun (2004) 319, 1327-1333. PubMed Europe PubMed DOI
[YEAR:6-8-2004]Longpre,J.M. and Leduc,R. Identification of prodomain determinants involved in ADAMTS-1 biosynthesis J Biol Chem (6-8-2004) 279, 33237-33245. PubMed Europe PubMed DOI
Mittaz,L., Russell,D.L., Wilson,T., Brasted,M., Tkalcevic,J., Salamonsen,L.A., Hertzog,P.J. and Pritchard,M.A. Adamts-1 is essential for the development and function of the urogenital system Biol Reprod (2004) 70, 1096-1105. PubMed Europe PubMed DOI
Wachsmuth,L., Bau,B., Fan,Z., Pecht,A., Gerwin,N. and Aigner,T. ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta J Rheumatol (2004) 31, 315-320. PubMed Europe PubMed

2003

Iruela-Arispe,M.L., Carpizo,D. and Luque,A. ADAMTS1: a matrix metalloprotease with angioinhibitory properties Ann N Y Acad Sci (2003) 995, 183-190. PubMed Europe PubMed
[YEAR:27-6-2003]Luque,A., Carpizo,D.R. and Iruela-Arispe,M.L. ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165 J Biol Chem (27-6-2003) 278, 23656-23665. PubMed Europe PubMed DOI
[YEAR:24-10-2003]Russell,D.L., Doyle,K.M., Ochsner,S.A., Sandy,J.D. and Richards,J.S. Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation J Biol Chem (24-10-2003) 278, 42330-42339. PubMed Europe PubMed DOI

2002

[YEAR:26-4-2002]Rodriguez-Manzaneque,J.C., Westling,J., Thai,S.N., Luque,A., Knauper,V., Murphy,G., Sandy,J.D. and Iruela-Arispe,M.L. ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors Biochem Biophys Res Commun (26-4-2002) 293, 501-508. PubMed Europe PubMed DOI I
[YEAR:26-4-2002]Wei,P., Zhao,Y.G., Zhuang,L., Hurst,D.R., Ruben,S. and Sang,Q.X. Protein engineering and properties of human metalloproteinase and thrombospondin 1 Biochem Biophys Res Commun (26-4-2002) 293, 478-488. PubMed Europe PubMed DOI
Yuan,W., Matthews,R.T., Sandy,J.D. and Gottschall,P.E. Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats Neuroscience (2002) 114, 1091-1101. PubMed Europe PubMed DOI

2001

Masui,T., Hosotani,R., Tsuji,S., Miyamoto,Y., Yasuda,S., Ida,J., Nakajima,S., Kawaguchi,M., Kobayashi,H., Koizumi,M., Toyoda,E., Tulachan,S., Arii,S., Doi,R. and Imamura,M. Expression of METH-1 and METH-2 in pancreatic cancer Clin Cancer Res (2001) 7, 3437-3443. PubMed Europe PubMed
[YEAR:20-4-2001]Sandy,J.D., Westling,J., Kenagy,R.D., Iruela-Arispe,M.L., Verscharen,C., Rodriguez-Mazaneque,J.C., Zimmermann,D.R., Lemire,J.M., Fischer,J.W., Wight,T.N. and Clowes,A.W. Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4 J Biol Chem (20-4-2001) 276, 13372-13378. PubMed Europe PubMed DOI
Tang,B.L. ADAMTS: a novel family of extracellular matrix proteases Int J Biochem Cell Biol (2001) 33, 33-44. PubMed Europe PubMed DOI

2000

Diamantis,I., Luthi,M., Hosli,M. and Reichen,J. Cloning of the rat ADAMTS-1 gene and its down regulation in endothelial cells in cirrhotic rats Liver (2000) 20, 165-172. PubMed Europe PubMed DOI
Espey,L.L., Yoshioka,S., Russell,D.L., Robker,R.L., Fujii,S. and Richards,J.S. Ovarian expression of a disintegrin and metalloproteinase with thrombospondin motifs during ovulation in the gonadotropin-primed immature rat Biol Reprod (2000) 62, 1090-1095. PubMed Europe PubMed
[YEAR:4-8-2000]Kuno,K., Okada,Y., Kawashima,H., Nakamura,H., Miyasaka,M., Ohno,H. and Matsushima,K. ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan FEBS Lett (4-8-2000) 478, 241-245. PubMed Europe PubMed DOI
Miles,R.R., Sluka,J.P., Halladay,D.L., Santerre,R.F., Hale,L.V., Bloem,L., Thirunavukkarasu,K., Galvin,R.J., Hock,J.M. and Onyia,J.E. ADAMTS-1: A cellular disintegrin and metalloprotease with thrombospondin motifs is a target for parathyroid hormone in bone Endocrinology (2000) 141, 4533-4542. PubMed Europe PubMed DOI
[YEAR:27-10-2000]Rodriguez-Manzaneque,J.C., Milchanowski,A.B., Dufour,E.K., Leduc,R. and Iruela-Arispe,M.L. Characterization of METH-1/ADAMTS1 processing reveals two distinct active forms J Biol Chem (27-10-2000) 275, 33471-33479. PubMed Europe PubMed DOI
Shindo,T., Kurihara,H., Kuno,K., Yokoyama,H., Wada,T., Kurihara,Y., Imai,T., Wang,Y., Ogata,M., Nishimatsu,H., Moriyama,N., Oh-hashi,Y., Morita,H., Ishikawa,T., Nagai,R., Yazaki,Y. and Matsushima,K. ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function J Clin Invest (2000) 105, 1345-1352. PubMed Europe PubMed DOI PMC EPMC

1999

[YEAR:25-6-1999]Kuno,K., Terashima,Y. and Matsushima,K. ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix J Biol Chem (25-6-1999) 274, 18821-18826. PubMed Europe PubMed DOI
[YEAR:26-2-1999]Tang,B.L. and Hong,W. ADAMTS: A novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats FEBS Lett (26-2-1999) 445, 223-225. PubMed Europe PubMed DOI
[YEAR:13-8-1999]Vazquez,F., Hastings,G., Ortega,M.A., Lane,T.F., Oikemus,S., Lombardo,M. and Iruela-Arispe,M.L. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity J Biol Chem (13-8-1999) 274, 23349-23357. PubMed Europe PubMed DOI

1998

[YEAR:29-5-1998]Kuno,K. and Matsushima,K. ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region J Biol Chem (29-5-1998) 273, 13912-13917. PubMed Europe PubMed DOI

1997

Kuno,K., Iizasa,H., Ohno,S. and Matsushima,K. The exon/intron organization and chromosomal mapping of the mouse ADAMTS-1 gene encoding an adam family protein with tsp motifs Genomics (1997) 46, 466-471. PubMed Europe PubMed DOI