Sequence features for peptidase M12.222: ADAMTS1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Metal ligands Source
MER0690186 Acanthisitta chloris 737 9-223 E158 H157, H161, H167 GENBANK:XP_009076468
MER0268361 Ailuropoda melanoleuca 1176 466-676 E611 H610, H614, H620 GENBANK:XP_002920115
MER0829529 Ailuropoda melanoleuca 963 254-413 E397 H396, H400, H406 GENBANK:-
MER0292983 Alligator mississippiensis 879 151-365 E300 H299, H303, H309 GENBANK:XP_006278956
MER0308598 Alligator sinensis 751 23-237 E172 H171, H175, H181 GENBANK:XP_006021455
MER0332902 Anas platyrhynchos 821 84-298 E233 H232, H236, H242 GENBANK:XP_005011505
MER0226086 Anolis carolinensis 932 209-418 E353 H352, H356, H362 UNIPROT:G1KQ54
MER0226086 Anolis carolinensis 932 209-418 E353 H352, H356, H362 UNIPROT:G1KQ54
MER0686037 Apaloderma vittatum 735 7-221 E156 H155, H159, H165 GENBANK:XP_009877285
MER0687104 Aptenodytes forsteri 728 9-223 E158 H157, H161, H167 GENBANK:XP_009281337
MER0686590 Aquila chrysaetos 910 182-396 E331 H330, H334, H340 GENBANK:XP_011592126
MER0555058 Astatotilapia burtoni 948 216-425 E365 H364, H368, H374 GENBANK:XP_005920058
MER0380298 Astyanax mexicanus 915 190-399 E339 H338, H342, H348 UNIPROT:W5L6Z7
MER0380298 Astyanax mexicanus 915 190-399 E339 H338, H342, H348 UNIPROT:W5L6Z7
MER0384604 Balaenoptera acutorostrata 945 226-440 E375 H374, H378, H384 GENBANK:XP_007164215
MER0682276 Balearica regulorum 654 6-220 E155 H154, H158, H164 GENBANK:XP_010299605
MER0679400 Bison bison 926 212-426 E361 H360, H364, H370 GENBANK:XP_010836771
MER0429513 Bos grunniens 1028 314-528 E463 H462, H466, H472 GENBANK:XP_005910946
MER0829655 Bos grunniens 964 256-416 E399 H398, H402, H408 UNIPROT:L8HQ26
MER0829655 Bos grunniens 964 256-416 E399 H398, H402, H408 UNIPROT:L8HQ26
MER0078783 Bos taurus 970 256-470 E405 H404, H408, H414 GENBANK:NP_001094550
MER0581181 Bubalus bubalis 969 255-469 E404 H403, H407, H413 GENBANK:XP_006075704
MER0678366 Buceros rhinoceros 737 9-223 E158 H157, H161, H167 GENBANK:XP_010142750
MER0357796 Callithrix jacchus 1225 515-725 E660 H659, H663, H669 GENBANK:XP_002807813
MER0582251 Calypte anna 788 60-274 E209 H208, H212, H218 GENBANK:XP_008494938
MER0675445 Camelus dromedarius 963 249-463 E398 H397, H401, H407 GENBANK:XP_010975690
MER0522687 Camelus ferus 705 1-205 E140 H139, H143, H149 UNIPROT:S9WWV0
MER0522687 Camelus ferus 705 1-205 E140 H139, H143, H149 UNIPROT:S9WWV0
MER0357782 Canis lupus familiaris 940 230-390 E375 H374, H378, H384 UNIPROT:F1PGL0
MER0357782 Canis lupus familiaris 940 230-390 E375 H374, H378, H384 UNIPROT:F1PGL0
MER0555974 Capra hircus 1137 423-637 E572 H571, H575, H581 GENBANK:XP_005674811
MER0675857 Cariama cristata 581 1-167 E102 H101, H105, H111 GENBANK:XP_009699199
MER0270778 Cavia porcellus 1244 535-744 E679 H678, H682, H688 GENBANK:XP_003467341
MER0525037 Ceratotherium simum 948 234-448 E383 H382, H386, H392 GENBANK:XP_004429583
MER0585611 Cercopithecus sabaeus 967 253-467 E402 H401, H405, H411 GENBANK:XP_007964129
MER0672878 Chaetura pelagica 736 8-222 E157 H156, H160, H166 GENBANK:XP_009993290
MER0671743 Charadrius vociferus 814 86-300 E235 H234, H238, H244 GENBANK:XP_009893234
MER0592131 Chelonia mydas 904 188-402 E337 H336, H340, H346 GENBANK:XP_007070802
MER0829577 Chelonia mydas 1365 672-830 E227, E815 H226, H814, H230, H818, H236, H824 UNIPROT:M7ARI9
MER0829577 Chelonia mydas 1365 672-830 E227, E815 H226, H814, H230, H818, H236, H824 UNIPROT:M7ARI9
MER0582969 Chinchilla lanigera 949 235-449 E384 H383, H387, H393 GENBANK:XP_005375658
MER0577426 Chrysemys picta 934 206-420 E355 H354, H358, H364 GENBANK:XP_005289357
MER0575671 Chrysochloris asiatica 928 214-428 E363 H362, H366, H372 GENBANK:XP_006872539
MER0828888 Ciona savignyi 851 188-349 E331 H330, H334, H340 UNIPROT:H2ZNU2
MER0829144 Ciona savignyi 907 164-325 E307 H306, H310, H316 UNIPROT:H2ZNU5
MER0829374 Ciona savignyi 909 164-325 E307 H306, H310, H316 UNIPROT:H2ZNU4
MER0829633 Ciona savignyi 864 167-328 E310 H309, H313, H319 UNIPROT:H2ZNU3
MER0829781 Ciona savignyi 878 163-324 E306 H305, H309, H315 UNIPROT:H2ZNU0
MER0671511 Colius striatus 680 9-223 E158 H157, H161, H167 GENBANK:XP_010199433
MER0670270 Colobus angolensis 967 253-467 E402 H401, H405, H411 GENBANK:XP_011781874
MER0579274 Columba livia 751 23-237 E172 H171, H175, H181 GENBANK:XP_005511456
MER0573679 Condylura cristata 946 232-446 E381 H380, H384, H390 GENBANK:XP_004675376
MER0572722 Corvus brachyrhynchos 735 61-275 E210 H209, H213, H219 GENBANK:XP_008631470
MER0667491 Corvus cornix 727 95-309 E244 H243, H247, H253 GENBANK:XP_010389677
MER0357747 Cricetulus griseus 967 258-467 E402 H401, H405, H411 GENBANK:XP_003509840
MER0357845 Cricetulus griseus 705 30-205 E140 H139, H143, H149 UNIPROT:G3I3J3
MER0357845 Cricetulus griseus 705 30-205 E140 H139, H143, H149 UNIPROT:G3I3J3
MER0665692 Cuculus canorus 763 35-249 E184 H183, H187, H193 GENBANK:XP_009565473
MER0568179 Cynoglossus semilaevis 943 213-427 E362 H361, H365, H371 GENBANK:XP_008323452
MER0165134 Danio rerio 873 183-352 E332 H331, H335, H341 UNIPROT:H9GXE0
MER0165134 Danio rerio 873 183-352 E332 H331, H335, H341 UNIPROT:H9GXE0
MER0347402 Desmodus rotundus 946 237-446 E381 H380, H384, H390 UNIPROT:K9IUF6
MER0347402 Desmodus rotundus 946 237-446 E381 H380, H384, H390 UNIPROT:K9IUF6
MER0664737 Egretta garzetta 745 17-231 E166 H165, H169, H175 GENBANK:XP_009639182
MER0565707 Elephantulus edwardii 948 234-448 E383 H382, H386, H392 GENBANK:XP_006896089
MER0563850 Eptesicus fuscus 948 235-447 E384 H383, H387, H393 GENBANK:XP_008143967
MER0027221 Equus caballus 726 12-226 E161 H160, H164, H170 GENBANK:XP_001496538
MER0561423 Equus przewalskii 541 1-41 missing missing, missing, missing GENBANK:XP_008509842
MER0561478 Equus przewalskii 147 1-142 E140 H139, missing, missing GENBANK:XP_008510481
MER0661593 Esox lucius 945 217-426 E366 H365, H369, H375 GENBANK:XP_010902694
MER0652997 Eurypyga helias 576 9-223 E158 H157, H161, H167 GENBANK:XP_010158163
MER0560546 Falco cherrug 773 45-259 E194 H193, H197, H203 GENBANK:XP_005438988
MER0545741 Falco peregrinus 748 20-234 E169 H168, H172, H178 GENBANK:XP_005240671
MER0610457 Felis catus 904 190-403 E339 H338, H342, H348 GENBANK:XP_006936020
MER0568548 Ficedula albicollis 683 29-243 E178 H177, H181, H187 GENBANK:XP_005038967
MER0656939 Fukomys damarensis 949 235-449 E384 H383, H387, H393 UNIPROT:A0A091DFJ8
MER0656939 Fukomys damarensis 949 235-449 E384 H383, H387, H393 UNIPROT:A0A091DFJ8
MER0654549 Fulmarus glacialis 730 6-220 E155 H154, H158, H164 GENBANK:XP_009571902
MER0557432 Galeopterus variegatus 964 250-464 E399 H398, H402, H408 GENBANK:XP_008589582
MER0178476 Gallus gallus 924 196-410 E345 H344, H348, H354 GENBANK:XP_416687
MER0654056 Gavia stellata 654 7-221 E156 H155, H159, H165 GENBANK:XP_009808756
MER0521443 Geospiza fortis 685 50-264 E199 H198, H202, H208 GENBANK:XP_005430502
MER0347791 Gorilla gorilla 967 257-417 E402 H401, H405, H411 UNIPROT:G3QWN6
MER0347791 Gorilla gorilla 967 257-417 E402 H401, H405, H411 UNIPROT:G3QWN6
MER0653381 Haliaeetus albicilla 570 7-221 E156 H155, H159, H165 GENBANK:XP_009921951
MER0651256 Haliaeetus leucocephalus 743 15-229 E164 H163, H167, H173 GENBANK:XP_010583636
MER0357892 Heterocephalus glaber 960 236-460 E380 H379, H398, H404 UNIPROT:G5C6W8
MER0357892 Heterocephalus glaber 960 236-460 E380 H379, H398, H404 UNIPROT:G5C6W8
MER0549471 Heterocephalus glaber 1113 399-613 E548 H547, H551, H557 GENBANK:XP_004907466
MER0005546 Homo sapiens 967 253-467 E402 H401, H405, H411 GENBANK:BAG11309
MER0005546 Homo sapiens 967 253-467 E402 H401, H405, H411 GENBANK:BAG11309
MER0005546 Homo sapiens 967 253-467 E402 H401, H405, H411 GENBANK:BAG11309
MER0005546 Homo sapiens 967 253-467 E402 H401, H405, H411 GENBANK:BAG11309
MER0548194 Jaculus jaculus 1192 478-692 E627 H626, H630, H636 GENBANK:XP_004654608
MER0650235 Larimichthys crocea 942 216-425 E365 H364, H368, H374 GENBANK:XP_010752626
MER0554494 Lepisosteus oculatus 903 215-422 E364 H363, H367, H373 GENBANK:XP_006638109
MER0552624 Leptonychotes weddellii 938 224-438 E373 H372, H376, H382 GENBANK:XP_006739027
MER0829839 Leptosomus discolor 679 4-144 E128, H127, H131, H137, UNIPROT:A0A091Q183
MER0829839 Leptosomus discolor 679 4-144 E128, H127, H131, H137, UNIPROT:A0A091Q183
MER0549832 Lipotes vexillifer 940 226-440 E375 H374, H378, H384 GENBANK:XP_007466563
MER0357717 Loxodonta africana 949 240-449 E384 H383, H387, H393 GENBANK:XP_003410371
MER0357825 Macaca fascicularis 873 163-326 E308 H307, H311, H317 UNIPROT:G8F2G3
MER0357825 Macaca fascicularis 873 163-326 E308 H307, H311, H317 UNIPROT:G8F2G3
MER0164612 Macaca mulatta 967 253-467 E402 H401, H405, H411 GENBANK:XP_001103864
MER0647599 Manacus vitellinus 796 68-282 E217 H216, H220, H226 GENBANK:XP_008923159
MER0646117 Mandrillus leucophaeus 967 253-467 E402 H401, H405, H411 GENBANK:XP_011853705
MER0542498 Maylandia zebra 948 216-428 E365 H364, H368, H374 GENBANK:XP_004552686
MER0467816 Meleagris gallopavo 739 11-225 E160 H159, H163, H169 GENBANK:XP_003202928
MER0541128 Melopsittacus undulatus 738 7-221 E156 H155, H159, H165 GENBANK:XP_005151692
MER0644461 Merops nubicus 639 9-223 E158 H157, H161, H167 GENBANK:XP_008937667
MER0643261 Mesitornis unicolor 737 9-223 E158 H157, H161, H167 GENBANK:XP_010188911
MER0544128 Mesocricetus auratus 966 252-466 E401 H400, H404, H410 GENBANK:XP_005073916
MER0539109 Microtus ochrogaster 967 253-467 E402 H401, H405, H411 GENBANK:XP_005345356
MER0357769 Monodelphis domestica 962 244-453 E388 H387, H391, H397 GENBANK:XP_003341220
MER0003183 Mus musculus 968 254-468 E403 H402, H406, H412 PIR:T00017
MER0003183 Mus musculus 968 254-468 E403 H402, H406, H412 PIR:T00017
MER0357755 Mustela putorius 214 7-214 E152 H151, H155, H161 UNIPROT:M1EFX0
MER0357755 Mustela putorius 214 7-214 E152 H151, H155, H161 UNIPROT:M1EFX0
MER0571299 Myotis brandtii 895 182-395 E331 H330, H334, H340 GENBANK:XP_005880710
MER0348176 Myotis davidii 704 1-204 E140 H139, H143, H149 UNIPROT:L5M8H0
MER0348176 Myotis davidii 704 1-204 E140 H139, H143, H149 UNIPROT:L5M8H0
MER0638956 Nannospalax galili 967 253-467 E402 H401, H405, H411 GENBANK:XP_008854317
MER0534710 Neolamprologus brichardi 948 216-425 E365 H364, H368, H374 GENBANK:XP_006805056
MER0638938 Nestor notabilis 663 9-223 E158 H157, H161, H167 GENBANK:XP_010014679
MER0583312 Nipponia nippon 799 61-275 E210 H209, H213, H219 GENBANK:XP_009471815
MER0256978 Nomascus leucogenys 967 257-467 E402 H401, H405, H411 UNIPROT:G1QR38
MER0256978 Nomascus leucogenys 967 257-467 E402 H401, H405, H411 UNIPROT:G1QR38
MER0635348 Notothenia coriiceps 946 216-430 E365 H364, H368, H374 GENBANK:XP_010780107
MER0533411 Octodon degus 949 235-449 E384 H383, H387, H393 GENBANK:XP_004627761
MER0531238 Odobenus rosmarus 952 238-452 E387 H386, H390, H396 GENBANK:XP_004413724
MER0828913 Oncorhynchus mykiss 849 197-355 E340 H339, H343, H349 UNIPROT:A0A060WNS7
MER0828913 Oncorhynchus mykiss 849 197-355 E340 H339, H343, H349 UNIPROT:A0A060WNS7
MER0828984 Oncorhynchus mykiss 946 224-384 E366 H365, H369, H375 UNIPROT:A0A060X1M4
MER0828984 Oncorhynchus mykiss 946 224-384 E366 H365, H369, H375 UNIPROT:A0A060X1M4
MER0829040 Oncorhynchus mykiss 850 197-355 E340 H339, H343, H349 UNIPROT:A0A060X345
MER0829040 Oncorhynchus mykiss 850 197-355 E340 H339, H343, H349 UNIPROT:A0A060X345
MER0829245 Oncorhynchus mykiss 763 54-191 E176 H175, H179, H185 UNIPROT:A0A060W202
MER0829245 Oncorhynchus mykiss 763 54-191 E176 H175, H179, H185 UNIPROT:A0A060W202
MER0829324 Oncorhynchus mykiss 945 223-383 E365 H364, H368, H374 UNIPROT:A0A060X769
MER0829324 Oncorhynchus mykiss 945 223-383 E365 H364, H368, H374 UNIPROT:A0A060X769
MER0829394 Ophiophagus hannah 962 243-403 E386 H385, H389, H395 UNIPROT:V8P032
MER0829394 Ophiophagus hannah 962 243-403 E386 H385, H389, H395 UNIPROT:V8P032
MER0633775 Opisthocomus hoazin 620 17-231 E166 H165, H169, H175 GENBANK:XP_009931670
MER0529064 Orcinus orca 940 226-440 E375 H374, H378, H384 GENBANK:XP_004264534
MER0357781 Oreochromis niloticus 1032 306-515 E450 H449, H453, H459 GENBANK:XP_003440996
MER0528079 Orycteropus afer 948 234-448 E383 H382, H386, H392 GENBANK:XP_007941694
MER0091088 Oryzias latipes 934 204-418 E353 H352, H356, H362 GENBANK:NP_001098186
MER0256360 Otolemur garnettii 943 256-465 E400 H399, H403, H409 GENBANK:XP_003784041
MER0618836 Ovis aries 968 254-468 E403 H402, H406, H412 UNIPROT:W5PZU6
MER0618836 Ovis aries 968 254-468 E403 H402, H406, H412 UNIPROT:W5PZU6
MER0357837 Pan paniscus 965 255-465 E400 H399, H403, H409 GENBANK:XP_003816719
MER0357839 Pan troglodytes 967 257-467 E402 H401, H405, H411 UNIPROT:H2QKW0
MER0357839 Pan troglodytes 967 257-467 E402 H401, H405, H411 UNIPROT:H2QKW0
MER0518999 Panthera tigris 748 34-247 E183 H182, H186, H192 GENBANK:XP_007075120
MER0517477 Pantholops hodgsonii 829 115-329 E264 H263, H267, H273 GENBANK:XP_005974053
MER0347697 Papio anubis 967 257-420 E402 H401, H405, H411 UNIPROT:A0A096NAB7
MER0347697 Papio anubis 967 257-420 E402 H401, H405, H411 UNIPROT:A0A096NAB7
MER0633057 Pelecanus crispus 607 9-223 E158 H157, H161, H167 GENBANK:XP_009481565
MER0524850 Pelodiscus sinensis 767 39-253 E188 H187, H191, H197 GENBANK:XP_006128933
MER0632133 Phaethon lepturus 736 8-222 E157 H156, H160, H166 GENBANK:XP_010290475
MER0630208 Phalacrocorax carbo 534 1-188 E123 H122, H126, H132 GENBANK:XP_009501359
MER0520143 Physeter catodon 705 1-205 E140 H139, H143, H149 GENBANK:XP_007124215
MER0627892 Picoides pubescens 746 18-232 E167 H166, H170, H176 GENBANK:XP_009903994
MER0829454 Podiceps cristatus 714 11-170 E154 H153, H157, H163 UNIPROT:A0A094MRG7
MER0829454 Podiceps cristatus 714 11-170 E154 H153, H157, H163 UNIPROT:A0A094MRG7
MER0522230 Poecilia formosa 945 215-429 E364 H363, H367, H373 UNIPROT:A0A096LWW1
MER0522230 Poecilia formosa 945 215-429 E364 H363, H367, H373 UNIPROT:A0A096LWW1
MER0514871 Poecilia reticulata 945 215-429 E364 H363, H367, H373 GENBANK:XP_008425848
MER0171598 Pongo abelii 911 253-467 E402 H401, H405, H411 UNIPROT:Q5R6D5
MER0171598 Pongo abelii 911 253-467 E402 H401, H405, H411 UNIPROT:Q5R6D5
MER0091164 Pongo pygmaeus 911 253-467 E402 H401, H405, H411 UNIPROT:Q5R6D5
MER0091164 Pongo pygmaeus 911 253-467 E402 H401, H405, H411 UNIPROT:Q5R6D5
MER0592655 Pterocles gutturalis 734 9-223 E158 H157, H161, H167 GENBANK:XP_010077743
MER0347388 Pteropus alecto 552 239-399 E383 H382, H386, H392 UNIPROT:L5KXN6
MER0347388 Pteropus alecto 552 239-399 E383 H382, H386, H392 UNIPROT:L5KXN6
MER0829538 Pygoscelis adeliae 637 11-171 E154 H153, H157, H163 UNIPROT:A0A093P6F3
MER0829538 Pygoscelis adeliae 637 11-171 E154 H153, H157, H163 UNIPROT:A0A093P6F3
MER0438995 Python bivittatus 938 214-428 E363 H362, H366, H372 GENBANK:XP_007430227
MER0005623 Rattus norvegicus 967 253-467 E402 H401, H405, H411 UNIPROT:Q9WUQ1
MER0005623 Rattus norvegicus 967 253-467 E402 H401, H405, H411 UNIPROT:Q9WUQ1
MER0005623 Rattus norvegicus 967 253-467 E402 H401, H405, H411 UNIPROT:Q9WUQ1
MER0569559 Rhinopithecus roxellana 967 253-467 E402 H401, H405, H411 GENBANK:XP_010381748
MER0347667 Saimiri boliviensis 964 254-464 E399 H398, H402, H408 GENBANK:XP_003934395
MER0357731 Sarcophilus harrisii 949 240-449 E384 H383, H387, H393 UNIPROT:G3WKJ9
MER0357731 Sarcophilus harrisii 949 240-449 E384 H383, H387, H393 UNIPROT:G3WKJ9
MER0513048 Serinus canaria 726 32-246 E181 H180, H184, H190 GENBANK:XP_009090996
MER0476906 Stegastes partitus 946 216-425 E365 H364, H368, H374 GENBANK:XP_008280109
MER0503931 Struthio camelus 781 53-267 E202 H201, H205, H211 GENBANK:XP_009665956
MER0122425 Sus scrofa 947 233-447 E382 H381, H385, H391 UNIPROT:Q2N1I7
MER0122425 Sus scrofa 947 233-447 E382 H381, H385, H391 UNIPROT:Q2N1I7
MER0169439 Taeniopygia guttata 863 135-349 E284 H283, H287, H293 GENBANK:XP_002189401
MER0829200 Taeniopygia guttata 886 175-335 E318 H317, H321, H327 GENBANK:-
MER0366270 Tauraco erythrolophus 737 9-223 E158 H157, H161, H167 GENBANK:XP_009983334
MER0091116 Tetraodon nigroviridis 627 124-338 E273 H272, H276, H282 UNIPROT:Q4RY31
MER0091116 Tetraodon nigroviridis 627 124-338 E273 H272, H276, H282 UNIPROT:Q4RY31
MER0467947 Tetraodon nigroviridis 901 184-440 E333 H332, H365, H371 UNIPROT:Q4RYQ0
MER0467947 Tetraodon nigroviridis 901 184-440 E333 H332, H365, H371 UNIPROT:Q4RYQ0
MER0468360 Tinamus guttatus 762 34-248 E183 H182, H186, H192 GENBANK:XP_010213809
MER0485631 Trichechus manatus 943 229-443 E378 H377, H381, H387 GENBANK:XP_004371419
MER0347107 Tupaia chinensis 957 248-457 E392 H391, H395, H401 GENBANK:ELW48934
MER0457528 Tyto alba 569 9-221 E158 H157, G160, F168 GENBANK:XP_009964454
MER0250283 Ursus maritimus 735 21-235 E170 H169, H173, H179 GENBANK:XP_008700156
MER0091169 Xenopus laevis 928 203-417 E352 H351, H355, H361 GENBANK:NP_001088627
MER0122452 Xenopus tropicalis 927 202-416 E351 H350, H354, H360 UNIPROT:B2GUP2
MER0122452 Xenopus tropicalis 927 202-416 E351 H350, H354, H360 UNIPROT:B2GUP2
MER0453317 Xiphophorus maculatus 944 214-428 E363 H362, H366, H372 GENBANK:XP_005805064
MER0448132 Zonotrichia albicollis 792 61-275 E210 H209, H213, H219 GENBANK:XP_005491080