Literature for peptidase M12.209: ADAM9 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, M Mutation, T Target, R Splicing, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2024

AmeliMojarad,M., AmeliMojarad,M., Wang,J., Tavakolpour,V. and Shariati,P. A pan-cancer study of ADAM9's immunological function and prognostic value particularly in liver cancer Sci Rep (2024) 14, 26862-26862. PubMed Europe PubMed DOI PMC EPMC
Bazzone,L.E., Zhu,J., King,M., Liu,G., Guo,Z., Mackay,C.R., Kyawe,P.P., Qaisar,N., Rojas-Quintero,J., Owen,C.A., Brass,A.L., McDougall,W., Baer,C.E., Cashman,T., Trivedi,C.M., Gack,M.U., Finberg,R.W. and Kurt-Jones,E.A. ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection Nat Commun (2024) 15, 4153-4153. PubMed Europe PubMed DOI PMC EPMC
Huang,Y.K., Cheng,W.C., Kuo,T.T., Yang,J.C., Wu,Y.C., Wu,H.H., Lo,C.C., Hsieh,C.Y., Wong,S.C., Lu,C.H., Wu,W.L., Liu,S.J., Li,Y.C., Lin,C.C., Shen,C.N., Hung,M.C., Lin,J.T., Yeh,C.C. and Sher,Y.P. Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy Nat Cancer (2024) 5, 400-419. PubMed Europe PubMed DOI
Jotatsu,Y., Sung,S.Y., Wu,M.H., Takeda,S., Hirata,Y., Maeda,K., Fang,S.B., Chen,K.C. and Shigemura,K. An Antibody of the Secreted Isoform of Disintegrin and Metalloprotease 9 (sADAM9) Inhibits Epithelial-Mesenchymal Transition and Migration of Prostate Cancer Cell Lines Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC K
Liu,J., Wang,Y., Zhang,S., Sun,L. and Shi,Y. ADAM9 deubiquitination induced by USP22 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of trophoblast cells in preeclampsia Placenta (2024) 146, 50-57. PubMed Europe PubMed DOI

2022

Chandrasekera,P., Perfetto,M., Lu,C., Zhuo,M., Bahudhanapati,H., Li,J., Chen,W.C., Kulkarni,P., Christian,L., Liu,J., Yien,Y.Y., Yu,C. and Wei,S. Metalloprotease ADAM9 cleaves ephrin-B ligands and differentially regulates Wnt and mTOR signaling downstream of Akt kinase in colorectal cancer cells J Biol Chem (2022) 298, 102225-102225. PubMed Europe PubMed DOI K
Liu,Z.H., Liu,W.J., Yu,X.Y., Qi,X.L. and Sun,C.C. Circ_0005276 aggravates the development of epithelial ovarian cancer by targeting ADAM9 Eur Rev Med Pharmacol Sci (2022) 26, 3798-3798. PubMed Europe PubMed DOI
Xiao,Y., Ma,W., Hu,W., Di,Q., Zhao,X., Ma,X., Chen,X., Sun,P., Wu,H., Wu,Z. and Chen,W. Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation Mol Oncol (2022) 16, 388-404. PubMed Europe PubMed DOI

2021

Umeda,M., Yoshida,N., Hisada,R., Burbano,C., Orite,S.Y.K., Kono,M., Kyttaris,V.C., Krishfield,S., Owen,C.A. and Tsokos,G.C. ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-beta1 Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI PMC EPMC

2020

Retraction: miR-126a-3p induces proliferation, migration and invasion of trophoblast cells in preeclampsia-like rats through inhibiting a disintegrin and metalloprotease 9(ADAM9) Biosci Rep (2020) 40 PubMed Europe PubMed DOI PMC EPMC
Abety,A.N., Pach,E., Giebeler,N., Fromme,J.E., Aramadhaka,L.R., Mauch,C., Fox,J.W. and Zigrino,P. Loss of ADAM9 Leads to Modifications of the Extracellular Matrix Modulating Tumor Growth Biomolecules (2020) 10 PubMed Europe PubMed DOI
Lin,Y.W., Wen,Y.C., Chu,C.Y., Tung,M.C., Yang,Y.C., Hua,K.T., Pan,K.F., Hsiao,M., Lee,W.J. and Chien,M.H. Stabilization of ADAM9 by N-alpha-acetyltransferase 10 protein contributes to promoting progression of androgen-independent prostate cancer Cell Death Dis (2020) 11, 591-591. PubMed Europe PubMed DOI
Lu,W., Fei,A., Jiang,Y., Chen,L. and Wang,Y. Tetraspanin CD9 interacts with alpha-secretase to enhance its oncogenic function in pancreatic cancer Am J Transl Res (2020) 12, 5525-5537. PubMed Europe PubMed PMC EPMC K

2019

Baggen,J., Thibaut,H.J., Hurdiss,D.L., Wahedi,M., Marceau,C.D., van Vliet,A.L.W., Carette,J.E. and van Kuppeveld,F.J.M. Identification of the cell-surface protease ADAM9 as an entry factor for encephalomyocarditis virus MBio (2019) 10 PubMed Europe PubMed DOI PMC EPMC K
Wichert,R., Scharfenberg,F., Colmorgen,C., Koudelka,T., Schwarz,J., Wetzel,S., Potempa,B., Potempa,J., Bartsch,J.W., Sagi,I., Tholey,A., Saftig,P., Rose-John,S. and Becker-Pauly,C. Meprin beta induces activities of a disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage FASEB J (2019) 33, 11925-11940. PubMed Europe PubMed DOI

2018

Wang,X., Polverino,F., Rojas-Quintero,J., Zhang,D., Sanchez,J., Yambayev,I., Lindqvist,E., Virtala,R., Djukanovic,R., Davies,D.E., Wilson,S., O'Donnell,R., Cunoosamy,D., Hazon,P., Higham,A., Singh,D., Olsson,H. and Owen,C.A. A disintegrin and a metalloproteinase-9 (ADAM9): a novel proteinase culprit with multifarious contributions to COPD Am J Respir Crit Care Med (2018) 198, 1500-1518. PubMed Europe PubMed DOI

2017

Maretzky,T., Swendeman,S., Mogollon,E., Weskamp,G., Sahin,U., Reiss,K. and Blobel,C.P. Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays Biochem J (2017) 474, 1467-1479. PubMed Europe PubMed DOI I

2016

Moss,M.L., Minond,D., Yoneyama,T., Hansen,H.P., Vujanovic,N. and Rasmussen,F.H. An improved fluorescent substrate for assaying soluble and membrane-associated ADAM family member activities Anal Biochem (2016) 507, 13-17. PubMed Europe PubMed DOI A

2015

Bahudhanapati,H., Bhattacharya,S. and Wei,S. Evolution of vertebrate ADAM genes; duplication of testicular ADAMs from ancient ADAM9/9-like loci PLoS ONE (2015) 10, e0136281-e0136281. PubMed Europe PubMed DOI PMC EPMC
Chang,L., Gong,F. and Cui,Y. RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo Mol Med Rep (2015) 12, 1197-1204. PubMed Europe PubMed DOI K
Wong,E., Maretzky,T., Peleg,Y., Blobel,C.P. and Sagi,I. The functional maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 requires processing at a newly identified proprotein convertase (PC) cleavage site J Biol Chem (2015) 290, 12135-12146. PubMed Europe PubMed DOI

2014

Kim,J.M., Jeung,H.C., Rha,S.Y., Yu,E.J., Kim,T.S., Shin,Y.K., Zhang,X., Park,K.H., Park,S.W., Chung,H.C. and Powis,G. The effect of disintegrin-metalloproteinase ADAM9 in gastric cancer progression Mol Cancer Ther (2014) 13, 3074-3085. PubMed Europe PubMed DOI T

2012

Chan,K.M., Wong,H.L., Jin,G., Liu,B., Cao,R., Cao,Y., Lehti,K., Tryggvason,K. and Zhou,Z. MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis Dev Cell (2012) 22, 1176-1190. PubMed Europe PubMed DOI
Zigrino,P. and Mauch,C. ADAM9 [ISSN:978-0-12-407744-7] (2012) 3, 1101-1107. DOI

2011

Mongaret,C., Alexandre,J., Thomas-Schoemann,A., Bermudez,E., Chereau,C., Nicco,C., Goldwasser,F., Weill,B., Batteux,F. and Lemare,F. Tumor invasion induced by oxidative stress is dependent on membrane ADAM 9 protein and its secreted form Int J Cancer (2011) 129, 791-798. PubMed Europe PubMed DOI
Moss,M.L., Powell,G., Miller,M.A., Edwards,L., Qi,B., Sang,Q.X., De Strooper,B., Tesseur,I., Lichtenthaler,S.F., Taverna,M., Zhong,J.L., Dingwall,C., Ferdous,T., Schlomann,U., Zhou,P., Griffith,L.G., Lauffenburger,D.A., Petrovich,R. and Bartsch,J.W. ADAM9 inhibition increases membrane activity of ADAM10 and controls alpha-secretase processing of amyloid precursor protein J Biol Chem (2011) 286, 40443-40451. PubMed Europe PubMed DOI
Zigrino,P., Nischt,R. and Mauch,C. The disintegrin-like and cysteine-rich domains of ADAM-9 mediate interactions between melanoma cells and fibroblasts J Biol Chem (2011) 286, 6801-6807. PubMed Europe PubMed DOI PMC EPMC

2010

Fry,J.L. and Toker,A. Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration Cancer Res (2010) 70, 8187-8198. PubMed Europe PubMed DOI R
Kohga,K., Takehara,T., Tatsumi,T., Ishida,H., Miyagi,T., Hosui,A. and Hayashi,N. Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9 Hepatology (2010) 51, 1264-1273. PubMed Europe PubMed DOI
Mauch,C., Zamek,J., Abety,A.N., Grimberg,G., Fox,J.W. and Zigrino,P. Accelerated wound repair in ADAM-9 knockout animals J Invest Dermatol (2010) 130, 2120-2130. PubMed Europe PubMed DOI K
Moss,M.L., Rasmussen,F.H., Nudelman,R., Dempsey,P.J. and Williams,J. Fluorescent substrates useful as high-throughput screening tools for ADAM9 Comb Chem High Throughput Screen (2010) 13, 358-365. PubMed Europe PubMed DOI A

2009

Franzke,C.W., Bruckner-Tuderman,L. and Blobel,C.P. Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9 J Biol Chem (2009) 284, 23386-23396. PubMed Europe PubMed DOI PMC EPMC I
Guaiquil,V., Swendeman,S., Yoshida,T., Chavala,S., Campochiaro,P.A. and Blobel,C.P. ADAM9 is involved in pathological retinal neovascularization Mol Cell Biol (2009) 29, 2694-2703. PubMed Europe PubMed DOI PMC EPMC
Parry,D.A., Toomes,C., Bida,L., Danciger,M., Towns,K.V., McKibbin,M., Jacobson,S.G., Logan,C.V., Ali,M., Bond,J., Chance,R., Swendeman,S., Daniele,L.L., Springell,K., Adams,M., Johnson,C.A., Booth,A.P., Jafri,H., Rashid,Y., Banin,E., Strom,T.M., Farber,D.B., Sharon,D., Blobel,C.P., Pugh,E.N., Jr., Pierce,E.A. and Inglehearn,C.F. Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice Am J Hum Genet (2009) 84, 683-691. PubMed Europe PubMed DOI PMC EPMC M
Peduto,L. ADAM9 as a potential target molecule in cancer Curr Pharm Des (2009) 15, 2282-2287. PubMed Europe PubMed DOI T

2008

Deuss,M., Reiss,K. and Hartmann,D. Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17 Curr Alzheimer Res (2008) 5, 187-201. PubMed Europe PubMed DOI K V
Postina,R. A closer look at alpha-secretase Curr Alzheimer Res (2008) 5, 179-186. PubMed Europe PubMed DOI

2005

[YEAR:15-1-2005]Mahimkar,R.M., Visaya,O., Pollock,A.S. and Lovett,D.H. The disintegrin domain of ADAM9: a ligand for multiple beta1 renal integrins Biochem J (15-1-2005) 385, 461-468. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-6-2005]Mazzocca,A., Coppari,R., De Franco,R., Cho,J.Y., Libermann,T.A., Pinzani,M. and Toker,A. A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions Cancer Res (1-6-2005) 65, 4728-4738. PubMed Europe PubMed DOI
Peduto,L., Reuter,V.E., Shaffer,D.R., Scher,H.I. and Blobel,C.P. Critical function for ADAM9 in mouse prostate cancer Cancer Res (2005) 65, 9312-9319. PubMed Europe PubMed DOI T

2004

Blobel,C.P. ADAM9 [ISSN:0-12-079610-4] (2004) 2, 715-717. V
[YEAR:8-3-2004]Grutzmann,R., Luttges,J., Sipos,B., Ammerpohl,O., Dobrowolski,F., Alldinger,I., Kersting,S., Ockert,D., Koch,R., Kalthoff,H., Schackert,H.K., Saeger,H.D., Kloppel,G. and Pilarsky,C. ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma Br J Cancer (8-3-2004) 90, 1053-1058. PubMed Europe PubMed DOI PMC EPMC
[YEAR:15-6-2004]Shintani,Y., Higashiyama,S., Ohta,M., Hirabayashi,H., Yamamoto,S., Yoshimasu,T., Matsuda,H. and Matsuura,N. Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis Cancer Res (15-6-2004) 64, 4190-4196. PubMed Europe PubMed DOI
Wolfsberg,T.G. and White,J.M. ADAM metalloproteinases [ISSN:0-12-079610-4] (2004) 2, 709-714. V

2003

[YEAR:31-1-2003]Asai,M., Hattori,C., Szabo,B., Sasagawa,N., Maruyama,K., Tanuma,S. and Ishiura,S. Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase Biochem Biophys Res Commun (31-1-2003) 301, 231-235. PubMed Europe PubMed DOI
[YEAR:20-7-2003]O'Shea,C., McKie,N., Buggy,Y., Duggan,C., Hill,A.D., McDermott,E., O'Higgins,N. and Duffy,M.J. Expression of ADAM-9 mRNA and protein in human breast cancer Int J Cancer (20-7-2003) 105, 754-761. PubMed Europe PubMed DOI

2002

[YEAR:31-7-2002]Amour,A., Knight,C.G., English,W.R., Webster,A., Slocombe,P.M., Knauper,V., Docherty,A.J., Becherer,J.D., Blobel,C.P. and Murphy,G. The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs FEBS Lett (31-7-2002) 524, 154-158. PubMed Europe PubMed DOI
Hooper,N.M. and Turner,A.J. The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer s disease Curr Med Chem (2002) 9, 1107-1119. PubMed Europe PubMed I
[YEAR:3-5-2002]Hotoda,N., Koike,H., Sasagawa,N. and Ishiura,S. A secreted form of human ADAM9 has an alpha-secretase activity for APP Biochem Biophys Res Commun (3-5-2002) 293, 800-805. PubMed Europe PubMed DOI R
[YEAR:24-12-2002]Mohan,S., Thompson,G.R., Amaar,Y.G., Hathaway,G., Tschesche,H. and Baylink,D.J. ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts Biochemistry (24-12-2002) 41, 15394-15403. PubMed Europe PubMed DOI
Weskamp,G., Cai,H., Brodie,T.A., Higashyama,S., Manova,K., Ludwig,T. and Blobel,C.P. Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life Mol Cell Biol (2002) 22, 1537-1544. PubMed Europe PubMed DOI PMC EPMC K

2001

[YEAR:1-11-2001]Namba,K., Nishio,M., Mori,K., Miyamoto,N., Tsurudome,M., Ito,M., Kawano,M., Uchida,A. and Ito,Y. Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes Cell Immunol (1-11-2001) 213, 104-113. PubMed Europe PubMed DOI
Schwettmann,L. and Tschesche,H. Cloning and expression in Pichia pastoris of metalloprotease domain of ADAM 9 catalytically active against fibronectin Protein Expr Purif (2001) 21, 65-70. PubMed Europe PubMed DOI E
[YEAR:19-1-2001]Zhou,M., Graham,R., Russell,G. and Croucher,P.I. MDC-9 (ADAM-9/meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin Biochem Biophys Res Commun (19-1-2001) 280, 574-580. PubMed Europe PubMed DOI

2000

Mahimkar,R.M., Baricos,W.H., Visaya,O., Pollock,A.S. and Lovett,D.H. Identification, cellular distribution and potential function of the metalloprotease-disintegrin MDC9 in the kidney J Am Soc Nephrol (2000) 11, 595-603. PubMed Europe PubMed
Nath,D., Slocombe,P.M., Webster,A., Stephens,P.E., Docherty,A.J. and Murphy,G. Meltrin gamma (ADAM-9) mediates cellular adhesion through alpha(6)beta(1)integrin, leading to a marked induction of fibroblast cell motility J Cell Sci (2000) 113, 2319-2328. PubMed Europe PubMed

1999

[YEAR:15-10-1999]Koike,H., Tomioka,S., Sorimachi,H., Saido,T.C., Maruyama,K., Okuyama,A., Fujisawa-Sehara,A., Ohno,S., Suzuki,K. and Ishiura,S. Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein Biochem J (15-10-1999) 343, 371-375. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-11-1999]Nelson,K.K., Schlondorff,J. and Blobel,C.P. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta Biochem J (1-11-1999) 343, 673-680. PubMed Europe PubMed DOI PMC EPMC
[YEAR:5-2-1999]Roghani,M., Becherer,J.D., Moss,M.L., Atherton,R.E., Erdjument-Bromage,H., Arribas,J., Blackburn,R.K., Weskamp,G., Tempst,P. and Blobel,C.P. Metalloprotease-disintegrin MDC9: Intracellular maturation and catalytic activity J Biol Chem (5-2-1999) 274, 3531-3540. PubMed Europe PubMed DOI

1998

[YEAR:13-2-1998]Inoue,D., Reid,M., Lum,L., Kratzschmar,J., Weskamp,G., Myung,Y.M., Baron,R. and Blobel,C.P. Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells J Biol Chem (13-2-1998) 273, 4180-4187. PubMed Europe PubMed DOI
[YEAR:15-12-1998]Izumi,Y., Hirata,M., Hasuwa,H., Iwamoto,R., Umata,T., Miyado,K., Tamai,Y., Kurisaki,T., Sehara-Fujisawa,A., Ohno,S. and Mekada,E. A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKC delta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor EMBO J (15-12-1998) 17, 7260-7272. PubMed Europe PubMed DOI PMC EPMC
Olson,G.E., Winfrey,V.P., Matrisian,P.E., NagDas,S.K. and Hoffman,L.H. Blastocyst-dependent upregulation of metalloproteinase/disintegrin MDC9 expression in rabbit endometrium Cell Tissue Res (1998) 293, 489-498. PubMed Europe PubMed DOI

1996

Weskamp,G., Kratzschmar,J., Reid,M.S. and Blobel,C.P. MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains J Cell Biol (1996) 132, 717-726. PubMed Europe PubMed DOI PMC EPMC