$VAR1 = undef;

Summary for peptidase M12.209: ADAM9 peptidase

Names
MEROPS Name	ADAM9 peptidase
Other names	ADAM9, ADAM 19 [obs.], MDC9, meltrin gamma, metalloproteinase and disintegrin dendritic antigen marker, metalloproteinase 12

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.209
Holotype	ADAM9 peptidase (Mus musculus), Uniprot accession Q61072 (peptidase unit: 208-406), MERNUM MER0003081
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00191
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (7 cleavages)
Activity status	human: active (Blobel, 2004) mouse: active (by similarity) (Weskamp et al., 2002)
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/ADAM9
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	p/apv/avlr/ashsqa/s/lrs/r (based on 20 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	2	0	0	1	0	0	0	1
Pro	5	6	0	0	0	2	0	3
Ala	2	6	5	9	3	2	1	1
Val	2	5	4	0	1	2	2	2
Leu	1	0	3	0	2	2	6	2
Ile	0	0	0	0	0	0	0	0
Met	0	0	0	0	0	0	0	0
Phe	0	1	1	0	0	0	0	0
Tyr	0	0	0	2	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	2	0	0	4	7	7	4	1
Thr	0	0	0	0	1	1	0	1
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	2
Gln	0	0	1	0	4	0	1	0
Asp	0	0	0	0	0	0	0	0
Glu	3	0	0	0	0	0	0	0
Lys	0	0	0	0	0	2	1	0
Arg	2	1	3	1	0	1	4	5
His	0	0	2	3	0	1	0	0