$VAR1 = undef;

Summary for peptidase M12.144: atrolysin C

Names
MEROPS Name	atrolysin C
Other names	Crotalus atrox metalloendopeptidase c

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.144
Holotype	atrolysin C (Crotalus atrox), Uniprot accession P15167 (peptidase unit: 191-393), MERNUM MER0001126
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00185
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.42
Enzymology	BRENDA database
Proteolytic events	CutDB database (10 cleavages)
Physiology	Likely role in snake venom toxicity.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/-lf/lvg/-/- (based on 60 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	4	3	7	7	0	8	8	4
Pro	2	4	2	4	0	0	1	0
Ala	3	6	8	14	3	2	11	5
Val	4	3	7	1	3	11	2	6
Leu	5	0	5	1	24	13	8	6
Ile	4	1	3	0	1	1	1	4
Met	1	0	0	1	2	0	0	0
Phe	0	1	0	1	10	6	4	1
Tyr	2	0	2	2	2	6	5	1
Trp	0	0	0	0	0	0	1	0
Ser	3	6	5	3	4	0	1	4
Thr	3	6	1	1	0	3	0	2
Cys	1	0	1	6	2	0	5	1
Asn	1	1	1	5	0	0	1	4
Gln	0	1	2	0	4	2	1	3
Asp	4	5	3	1	0	0	2	4
Glu	5	8	7	5	0	0	2	2
Lys	1	1	1	1	0	0	0	0
Arg	0	0	1	1	0	2	0	0
His	3	2	0	2	5	1	1	0