Substrates for peptidase M10.023: membrane-type matrix metallopeptidase-5

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
amyloid-beta precursor protein P05067 18-770 peptide-Asn579+Met-peptide P AB Val Leu Ala Asn Met Ile Ser Glu Willem et al., 2015
metastasis-suppressor KiSS-1 Q15726 20-145 peptide-Gly118+Leu-peptide P Asn Ser Phe Gly Leu Arg Phe Gly Takino et al., 2003 4030
QF-24 Mca-Pro-Leu-Gly+Leu-Dpa-Ala-Arg-NH2 S Mca Pro Leu Gly Leu Dpa Ala Arg Pei, 2004