Summary for peptidase M10.023: membrane-type matrix metallopeptidase-5

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

 

Names
MEROPS Namemembrane-type matrix metallopeptidase-5
Other namesmembrane-type matrix metalloproteinase 5, MT5-MMP, MMP-24, MTMMP-5
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.023
Holotypemembrane-type matrix metallopeptidase-5 (Homo sapiens), Uniprot accession Q9Y5R2 (peptidase unit: 152-342), MERNUM MER0005638
History Identifier created: MEROPS 3.30 (20 July 1999)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Pei, 2004)
mouse: active (Wang et al., 1999)
PhysiologyMembrane-type matrix metalloproteinase 5 was identified as neuron-specific, and suggested to contribute to neuronal circuit formation and plasticity.
KnockoutDeficient mice were born normally, but showed abnormal responses to sciatic nerve injury (Komori et al., 2004).
Other databases TREEFAMhttp://www.treefam.org/family/TF352396
PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR10201:SF138
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMP24 20q11.2 ENSG00000125966 10893 MMP24 604871
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mmp24 2:H1 ENSMUSG00000027612 17391 MGI:1341867