$VAR1 = undef;

Summary for peptidase M10.023: membrane-type matrix metallopeptidase-5

Names
MEROPS Name	membrane-type matrix metallopeptidase-5
Other names	eta-secretase, membrane-type matrix metalloproteinase 5, MT5-MMP, MMP-24, MTMMP-5

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.023
Holotype	membrane-type matrix metallopeptidase-5 (Homo sapiens), Uniprot accession Q9Y5R2 (peptidase unit: 152-342), MERNUM MER0005638
History	Identifier created: MEROPS 3.30 (20 July 1999)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Pei, 2004) mouse: active (Wang et al., 1999)
Physiology	Membrane-type matrix metalloproteinase 5 was identified as neuron-specific, and suggested to contribute to neuronal circuit formation and plasticity.
Knockout	Deficient mice were born normally, but showed abnormal responses to sciatic nerve injury (Komori et al., 2004).
Other databases	TREEFAM	http://www.treefam.org/family/TF352396