Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q99217

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
16	unknown peptidase	1-205	P	release of a signal peptide	NT	Fincham et al., 1989
33	matrix metallopeptidase-20	17-191	P			Zhu et al., 2008
60	matrix metallopeptidase-20	17-191	P			Zhu et al., 2008
163	matrix metallopeptidase-20	17-191	P			Zhu et al., 2008
172	matrix metallopeptidase-20	17-191	P			Zhu et al., 2008
175	matrix metallopeptidase-20	17-191	P			Zhu et al., 2008
176	matrix metallopeptidase-20	17-191	P			Zhu et al., 2008
180	matrix metallopeptidase-20	17-191	P			Zhu et al., 2008