$VAR1 = undef;

Summary for peptidase M10.019: matrix metallopeptidase-20

Names
MEROPS Name	matrix metallopeptidase-20
Other names	enamelysin, matrix metalloproteinase 20, MMP-20

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.019
Holotype	matrix metallopeptidase-20 (Homo sapiens), Uniprot accession O60882 (peptidase unit: 106-287), MERNUM MER0003021
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00167
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (28 cleavages)
Activity status	human: active (Bartlett, 2004) mouse: active (Caterina et al., 2000)
Physiology	In vitro, enamelysin catalyzes all of the amelogenin cleavages that are known to occur during the secretory stage in vivo, and it is probably the enzyme responsible for the processing of all enamel proteins (Simmer & Hu, 2002).
Knockout	The enamelysin null mouse has a severe tooth phenotype (Caterina et al., 2002).
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/MMP20
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	p/-/l/plm/-/a/- (based on 43 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	2	5	6	2	0	3	2	2
Pro	19	8	1	13	0	1	6	6
Ala	1	8	3	6	4	2	9	0
Val	2	2	1	0	0	5	0	1
Leu	3	4	14	1	15	6	1	6
Ile	1	3	0	0	0	2	0	0
Met	4	5	1	0	6	2	0	2
Phe	0	1	3	2	1	2	0	0
Tyr	0	0	0	1	5	0	0	2
Trp	0	0	3	3	0	0	1	3
Ser	1	1	2	4	5	0	7	1
Thr	0	0	1	1	0	4	3	1
Cys	0	0	0	0	0	0	0	1
Asn	1	1	0	3	0	0	1	2
Gln	3	0	3	3	4	7	3	10
Asp	2	2	2	0	1	0	3	0
Glu	3	1	1	0	2	5	2	0
Lys	0	0	0	0	0	0	0	3
Arg	0	0	0	4	0	1	0	2
His	1	2	2	0	0	3	5	1