Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M10.019: matrix metallopeptidase-20

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, I Inhibitor, K Knockout, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2021
  1. Nikolopoulos,G., Smith,C.E.L., Poulter,J.A., Murillo,G., Silva,S., Lamb,T., Berry,I.R., Brown,C.J., Day,P.F., Soldani,F., Al-Bahlani,S., Harris,S.A., O'Connell,M.J., Inglehearn,C.F. and Mighell,A.J.<br>Spectrum of pathogenic variants and founder effects in amelogenesis imperfecta associated with MMP20<br>Hum Mutat (2021) PubMed  Europe PubMed DOI  M
    2. 2019
  2. Yamazaki,H., Tran,B., Beniash,E., Kwak,S.Y. and Margolis,H.C.<br>Proteolysis by MMP20 prevents aberrant mineralization in secretory enamel<br>J Dent Res (2019) 98, 468-475. PubMed  Europe PubMed DOI
    3. 2018
  3. Buchko,G.W., Jayasinha Arachchige,R., Tao,J., Tarasevich,B.J. and Shaw,W.J.<br>Identification of major matrix metalloproteinase-20 proteolytic processing products of murine amelogenin and tyrosine-rich amelogenin peptide using a nuclear magnetic resonance spectroscopy based method<br>Arch Oral Biol (2018) 93, 187-194. PubMed  Europe PubMed DOI  P
    4. 2016
  4. Kwak,S.Y., Yamakoshi,Y., Simmer,J.P. and Margolis,H.C.<br>MMP20 proteolysis of native amelogenin regulates mineralization in vitro<br>J Dent Res (2016) 95, 1511-1517. PubMed  Europe PubMed DOI
    5. 2013
  5. Khan,F., Liu,H., Reyes,A., Witkowska,H.E., Martinez-Avila,O., Zhu,L., Li,W. and Habelitz,S.<br>The proteolytic processing of amelogenin by enamel matrix metalloproteinase (MMP-20) is controlled by mineral ions<br>Biochim Biophys Acta (2013) 1830, 2600-2607. PubMed  Europe PubMed DOI
  6. Wang,S.K., Hu,Y., Simmer,J.P., Seymen,F., Estrella,N.M.R.P., Pal,S., Reid,B.M., Yildirim,M., Bayram,M., Bartlett,J.D. and Hu,J.C.C.<br>Novel KLK4 and MMP20 mutations discovered by whole-exome sequencing<br>J Dent Res (2013) 92, 266-271. PubMed  Europe PubMed DOI  M
  7. Yoon,H., Blaber,S.I., Li,W., Scarisbrick,I.A. and Blaber,M.<br>Activation profiles of human kallikrein-related peptidases by matrix metalloproteinases<br>Biol Chem (2013) 394, 137-147. PubMed  Europe PubMed DOI
    8. 2012
  8. Bartlett,J.D.<br>Matrix metalloproteinase-20/enamelysin<br>[ISSN:978-0-12-407744-7] (2012) 3, 835-840. DOI
    9. 2011
  9. Bartlett,J.D., Skobe,Z., Nanci,A. and Smith,C.E.<br>Matrix metalloproteinase 20 promotes a smooth enamel surface, a strong dentino-enamel junction, and a decussating enamel rod pattern<br>Eur J Oral Sci (2011) 119 Suppl 1, 199-205. PubMed  Europe PubMed DOI
  10. Hu,Y., Hu,J.C., Smith,C.E., Bartlett,J.D. and Simmer,J.P.<br>Kallikrein-related peptidase 4, matrix metalloproteinase 20, and the maturation of murine and porcine enamel<br>Eur J Oral Sci (2011) 119 Suppl 1, 217-225. PubMed  Europe PubMed DOI
  11. Kawasaki,K. and Suzuki,T.<br>Molecular evolution of matrix metalloproteinase 20<br>Eur J Oral Sci (2011) 119 Suppl 1, 247-253. PubMed  Europe PubMed DOI
  12. Meredith,R.W., Gatesy,J., Cheng,J. and Springer,M.S.<br>Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales<br>Proc Biol Sci (2011) 278, 993-1002. PubMed  Europe PubMed DOI
  13. Yamakoshi,Y., Richardson,A.S., Nunez,S.M., Yamakoshi,F., Milkovich,R.N., Hu,J.C., Bartlett,J.D. and Simmer,J.P.<br>Enamel proteins and proteases in Mmp20 and Klk4 null and double-null mice<br>Eur J Oral Sci (2011) 119 Suppl 1, 206-216. PubMed  Europe PubMed DOI  K
  14. Yang,X., Sun,Z., Ma,R., Fan,D. and Moradian-Oldak,J.<br>Amelogenin "nanorods" formation during proteolysis by Mmp-20<br>J Struct Biol (2011) 176, 220-228. PubMed  Europe PubMed DOI
    15. 2010
  15. Chun,Y.H., Yamakoshi,Y., Yamakoshi,F., Fukae,M., Hu,J.C., Bartlett,J.D. and Simmer,J.P.<br>Cleavage site specificity of MMP-20 for secretory-stage ameloblastin<br>J Dent Res (2010) 89, 785-790. PubMed  Europe PubMed DOI  P
  16. Lee,S.K., Seymen,F., Kang,H.Y., Lee,K.E., Gencay,K., Tuna,B. and Kim,J.W.<br>MMP20 hemopexin domain mutation in amelogenesis imperfecta<br>J Dent Res (2010) 89, 46-50. PubMed  Europe PubMed DOI  M
    17. 2009
  17. Nagano,T., Kakegawa,A., Yamakoshi,Y., Tsuchiya,S., Hu,J.C., Gomi,K., Arai,T., Bartlett,J.D. and Simmer,J.P.<br>Mmp-20 and Klk4 cleavage site preferences for amelogenin sequences<br>J Dent Res (2009) 88, 823-828. PubMed  Europe PubMed DOI  PMC  EPMC  P
    18. 2008
  18. Lu,Y., Papagerakis,P., Yamakoshi,Y., Hu,J.C., Bartlett,J.D. and Simmer,J.P.<br>Functions of KLK4 and MMP-20 in dental enamel formation<br>Biol Chem (2008) 389, 695-700. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Papagerakis,P., Lin,H.K., Lee,K.Y., Hu,Y., Simmer,J.P., Bartlett,J.D. and Hu,J.C.<br>Premature stop codon in MMP20 causing amelogenesis imperfecta<br>J Dent Res (2008) 87, 56-59. PubMed  Europe PubMed DOI  PMC  EPMC  M
  20. Zhu,L., Tanimoto,K., Robinsin,S., Chen,J., Witkowska,E., Hall,S., Le,T., Denbesten,P.K. and Li,W.<br>Comparative properties of recombinant human and bovine matrix metalloproteinase-20<br>Arch Oral Biol (2008) 53, 785-790. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2007
  21. Arendt,Y., Banci,L., Bertini,I., Cantini,F., Cozzi,R., Del Conte,R. and Gonnelli,L.<br>Catalytic domain of MMP20 (enamelysin) - the NMR structure of a new matrix metalloproteinase<br>FEBS Lett (2007) 581, 4723-4726. PubMed  Europe PubMed DOI  S  I
  22. Iwata,T., Yamakoshi,Y., Hu,J.C., Ishikawa,I., Bartlett,J.D., Krebsbach,P.H. and Simmer,J.P.<br>Processing of ameloblastin by MMP-20<br>J Dent Res (2007) 86, 153-157. PubMed  Europe PubMed DOI  P
  23. Shintani,S., Kobata,M., Kamakura,N., Toyosawa,S. and Ooshima,T.<br>Identification and characterization of matrix metalloproteinase-20 (MMP20; enamelysin) genes in reptile and amphibian<br>Gene (2007) 392, 89-97. PubMed  Europe PubMed DOI
    24. 2006
  24. Bartlett,J.D., Skobe,Z., Lee,D.H., Wright,J.T., Li,Y., Kulkarni,A.B. and Gibson,C.W.<br>A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamel<br>Eur J Oral Sci (2006) 114 Suppl 1, 18-23. PubMed  Europe PubMed DOI  K
  25. Beniash,E., Skobe,Z. and Bartlett,J.D.<br>Formation of the dentino-enamel interface in enamelysin (MMP-20)-deficient mouse incisors<br>Eur J Oral Sci (2006) 114 Suppl 1, 24-29. PubMed  Europe PubMed DOI  K
  26. [YEAR:28-3-2006]Turk,B.E., Lee,D.H., Yamakoshi,Y., Klingenhoff,A., Reichenberger,E., Wright,J.T., Simmer,J.P., Komisarof,J.A., Cantley,L.C. and Bartlett,J.D.<br>MMP-20 Is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen<br>Biochemistry (28-3-2006) 45, 3863-3874. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Yamakoshi,Y., Hu,J.C., Fukae,M., Yamakoshi,F. and Simmer,J.P.<br>How do enamelysin and kallikrein 4 process the 32-kDa enamelin?<br>Eur J Oral Sci (2006) 114 Suppl 1, 45-51. PubMed  Europe PubMed DOI
    28. 2005
  28. Kim,J.W., Simmer,J.P., Hart,T.C., Hart,P.S., Ramaswami,M.D., Bartlett,J.D. and Hu,J.C.<br>MMP-20 mutation in autosomal recessive pigmented hypomaturation amelogenesis imperfecta<br>J Med Genet (2005) 42, 271-275. PubMed  Europe PubMed DOI  PMC  EPMC  M
  29. Ozdemir,D., Hart,P.S., Ryu,O.H., Choi,S.J., Ozdemir-Karatas,M., Firatli,E., Piesco,N. and Hart,T.C.<br>MMP20 active-site mutation in hypomaturation amelogenesis imperfecta<br>J Dent Res (2005) 84, 1031-1035. PubMed  Europe PubMed DOI  PMC  EPMC  M
    30. 2004
  30. Bartlett,J.D.<br>Enamelysin<br>[ISSN:0-12-079610-4] (2004) 2, 561-564.  V
  31. Bartlett,J.D., Beniash,E., Lee,D.H. and Smith,C.E.<br>Decreased mineral content in MMP-20 null mouse enamel is prominent during the maturation stage<br>J Dent Res (2004) 83, 909-913. PubMed  Europe PubMed
  32. Bourd-Boittin,K., Septier,D., Hall,R., Goldberg,M. and Menashi,S.<br>Immunolocalization of enamelysin (matrix metalloproteinase-20) in the forming rat incisor<br>J Histochem Cytochem (2004) 52, 437-445. PubMed  Europe PubMed
    33. 2003
  33. Li,W., Gao,C., Yan,Y. and DenBesten,P.<br>X-linked amelogenesis imperfecta may result from decreased formation of tyrosine rich amelogenin peptide (TRAP)<br>Arch Oral Biol (2003) 48, 177-183. PubMed  Europe PubMed DOI
    34. 2002
  34. [YEAR:20-12-2002]Caterina,J.J., Skobe,Z., Shi,J., Ding,Y., Simmer,J.P., Birkedal-Hansen,H. and Bartlett,J.D.<br>Enamelysin (matrix metalloproteinase 20)-deficient mice display an amelogenesis imperfecta phenotype<br>J Biol Chem (20-12-2002) 277, 49598-49604. PubMed  Europe PubMed DOI  K
  35. Palosaari,H., Ding,Y., Larmas,M., Sorsa,T., Bartlett,J.D., Salo,T. and Tjaderhane,L.<br>Regulation and interactions of MT1-MMP and MMP-20 in human odontoblasts and pulp tissue in vitro<br>J Dent Res (2002) 81, 354-359. PubMed  Europe PubMed
  36. Simmer,J.P. and Hu,J.C.<br>Expression, structure, and function of enamel proteinases<br>Connect Tissue Res (2002) 43, 441-449. PubMed  Europe PubMed
  37. Sulkala,M., Larmas,M., Sorsa,T., Salo,T. and Tjaderhane,L.<br>The localization of matrix metalloproteinase-20 (MMP-20, enamelysin) in mature human teeth<br>J Dent Res (2002) 81, 603-607. PubMed  Europe PubMed
    38. 2001
  38. Li,W., Gibson,C.W., Abrams,W.R., Andrews,D.W. and Denbesten,P.K.<br>Reduced hydrolysis of amelogenin may result in X-linked amelogenesis imperfecta<br>Matrix Biol (2001) 19, 755-760. PubMed  Europe PubMed DOI
  39. Moradian-Oldak,J., Jimenez,I., Maltby,D. and Fincham,A.G.<br>Controlled proteolysis of amelogenins reveals exposure of both carboxy- and amino-terminal regions<br>Biopolymers (2001) 58, 606-616. PubMed  Europe PubMed DOI
    40. 2000
  40. Caterina,J., Shi,J., Sun,X., Qian,Q., Yamada,S., Liu,Y., Krakora,S., Bartlett,J.D., Yamada,Y., Engler,J.A., Birkedal-Hansen,H. and Simmer,J.P.<br>Cloning, characterization, and expression analysis of mouse enamelysin<br>J Dent Res (2000) 79, 1697-1703. PubMed  Europe PubMed
  41. [YEAR:28-7-2000]Stracke,J.O., Fosang,A.J., Last,K., Mercuri,F.A., Pendas,A.M., Llano,E., Perris,R., Di Cesare,P.E., Murphy,G. and Knauper,V.<br>Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)<br>FEBS Lett (28-7-2000) 478, 52-56. PubMed  Europe PubMed DOI
  42. Takata,T., Zhao,M., Uchida,T., Wang,T., Aoki,T., Bartlett,J.D. and Nikai,H.<br>Immunohistochemical detection and distribution of enamelysin (MMP-20) in human odontogenic tumors<br>J Dent Res (2000) 79, 1608-1613. PubMed  Europe PubMed
    43. 1999
  43. Bartlett,J.D. and Simmer,J.P.<br>Proteinases in developing dental enamel<br>Crit Rev Oral Biol Med (1999) 10, 425-441. PubMed  Europe PubMed
  44. [YEAR:1-12-1999]Caterina,J., Shi,J., Krakora,S., Bartlett,J.D., Engler,J.A., Kozak,C.A. and Birkedal-Hansen,H.<br>Isolation, characterization, and chromosomal location of the mouse enamelysin gene<br>Genomics (1-12-1999) 62, 308-311. PubMed  Europe PubMed DOI
  45. Li,W., Machule,D., Gao,C. and Denbesten,P.K.<br>Activation of recombinant bovine matrix metalloproteinase-20 and its hydrolysis of two amelogenin oligopeptides<br>Eur J Oral Sci (1999) 107, 352-359. PubMed  Europe PubMed
  46. Ryu,O.H., Fincham,A.G., Hu,C.C., Zhang,C., Qian,Q., Bartlett,J.D. and Simmer,J.P.<br>Characterization of recombinant pig enamelysin activity and cleavage of recombinant pig and mouse amelogenins<br>J Dent Res (1999) 78, 743-750. PubMed  Europe PubMed
    47. 1998
  47. Bartlett,J.D., Ryu,O.H., Xue,J., Simmer,J.P. and Margolis,H.C.<br>Enamelysin mRNA displays a developmentally defined pattern of expression and encodes a protein which degrades amelogenin<br>Connect Tissue Res (1998) 39, 101-109. PubMed  Europe PubMed
  48. Den Besten,P.K., Punzi,J.S. and Li,W.<br>Purification and sequencing of a 21 kDa and 25 kDa bovine enamel metalloproteinase<br>Eur J Oral Sci (1998) 106 Suppl 1, 345-349. PubMed  Europe PubMed
  49. Fukae,M., Tanabe,T., Uchida,T., Lee,S.K., Ryu,O.H., Murakami,C., Wakida,K., Simmer,J.P., Yamada,Y. and Bartlett,J.D.<br>Enamelysin (matrix metalloproteinase-20): Localization in the developing tooth and effects of pH and calcium on amelogenin hydrolysis<br>J Dent Res (1998) 77, 1580-1588. PubMed  Europe PubMed
  50. Woessner,J.F., Jr.<br>Role of matrix proteases in processing enamel proteins<br>Connect Tissue Res (1998) 39, 69-73. PubMed  Europe PubMed
    51. 1997
  51. [YEAR:9-12-1997]Llano,E., Pendas,A.M., Knauper,V., Sorsa,T., Salo,T., Salido,E., Murphy,G., Simmer,J.P., Bartlett,J.D. and Lopez-Otin,C.<br>Identification and structural and functional characterization of human enamelysin (MMP-20)<br>Biochemistry (9-12-1997) 36, 15101-15108. PubMed  Europe PubMed DOI
    52. 1996
  52. Bartlett,J.D., Simmer,J.P., Xue,J., Margolis,H.C. and Moreno,E.C.<br>Molecular cloning and mRNA tissue distribution of a novel matrix metalloproteinase isolated from porcine enamel organ<br>Gene (1996) 183, 123-128. PubMed  Europe PubMed DOI
  53. Moradian-Oldak,J., Sarte,P.E. and Fincham,A.G.<br>Description of two classes of proteinases from enamel extracellular matrix cleaving a recombinant amelogenin<br>Connect Tissue Res (1996) 35, 231-238. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use