Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P18859

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
24	mitochondrial processing peptidase beta-subunit	1-108	P	release of a transit peptide	MS	Van Damme P et al., 2005
32	mitochondrial intermediate peptidase	25-108	P	release of a transit peptide	MS	Van Damme P et al., 2005
36	meprin alpha subunit	1-108	N		MS	Becker-Pauly et al., 2011
36	meprin beta subunit	33-108	N		MS	Becker-Pauly et al., 2011
37	unknown peptidase	1-108	P		MS	Van Damme et al., 2005
82	cathepsin G	79-94	N		MS	Schilling & Overall, 2008
85	meprin beta subunit	82-94	N		MS	Becker-Pauly et al., 2011
94	trypsin 1	33-108	N		MS	Schilling & Overall, 2008
96	meprin beta subunit	93-108	N		MS	Becker-Pauly et al., 2011