Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P25705

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-553	P	release of an initiating methionine	MS	He et al., 2006
35	mitochondrial processing peptidase beta-subunit	1-553	P	release of a transit peptide	MS	Gevaert et al., 2003
43	mitochondrial intermediate peptidase	36-553	P	release of a transit peptide	MS	Gevaert et al., 2003
101	matrix metallopeptidase-2	97-127	N		MS	Schilling & Overall, 2008
127	glutamyl endopeptidase I	44-553	N		MS	Schilling & Overall, 2008
139	astacin	136-149	N		MS	Becker-Pauly et al., 2011
139	meprin alpha subunit	136-149	N		MS	Becker-Pauly et al., 2011
139	LAST_MAM peptidase (Limulus-type)	136-149	N		MS	Becker-Pauly et al., 2011
159	caspase-3	44-553	P		MS	Impens et al., 2010
313	unknown peptidase	1-553	P		MS	Van Damme et al., 2005