Literature for peptidase M01.024: ERAP2 aminopeptidase

(Topics flags: S Structure, M Mutation, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Su,S.H., Cai,X.Q., Li,Y.H., Xu,A.H., Huang,Q., Niu,H., You,Q.H. and Sun,G.Y.
   The important roles of ERAP1, ERAP2 genes polymorphisms and their DNA methylation levels in pulmonary tuberculosis
   BMC Infect Dis25, 178-178. PubMed  Europe PubMed DOI  M
2024
2. Al-Kaabi,M., Deshpande,P., Firth,M., Pavlos,R., Chopra,A., Basiri,H., Currenti,J., Alves,E., Kalams,S., Fellay,J., Phillips,E., Mallal,S., John,M. and Gaudieri,S.
   Epistatic interaction between ERAP2 and HLA modulates HIV-1 adaptation and disease outcome in an Australian population
   PLoS Pathog20, e1012359-e1012359. PubMed  Europe PubMed DOI
3. Zhang,J., Cai,H., Sun,W., Wu,W., Nan,Y., Ni,Y., Wu,X., Chen,M., Xu,H. and Wang,Y.
   Endoplasmic reticulum aminopeptidase 2 regulates CD4(+) T cells pyroptosis in rheumatoid arthritis
   Arthritis Res Ther26, 36-36. PubMed  Europe PubMed DOI  K
2023
4. Evnouchidou,I., Koumantou,D., Nugue,M. and Saveanu,L.
   M1-aminopeptidase family - beyond antigen-trimming activities
   Curr Opin Immunol83, 102337-102337. PubMed  Europe PubMed DOI  V
5. Hamilton,F., Mentzer,A.J., Parks,T., Baillie,J.K., Smith,G.D., Ghazal,P. and Timpson,N.J.
   Variation in ERAP2 has opposing effects on severe respiratory infection and autoimmune disease
   Am J Hum Genet110, 691-702. PubMed  Europe PubMed DOI  M
6. Limanaqi,F., Vicentini,C., Saulle,I., Clerici,M. and Biasin,M.
   The role of endoplasmic reticulum aminopeptidases in type 1 diabetes mellitus
   Life Sci323, 121701-121701. PubMed  Europe PubMed DOI  V
7. Raja,A. and Kuiper,J.J.W.
   Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2)
   Genes Immun24, 295-302. PubMed  Europe PubMed DOI  V
8. Schmidt,K., Leisegang,M. and Kloetzel,P.M.
   ERAP2 supports TCR recognition of three immunotherapy targeted tumor epitopes
   Mol Immunol154, 61-68. PubMed  Europe PubMed DOI
9. Tedeschi,V., Paldino,G., Alba,J., Molteni,E., Paladini,F., Scrivo,R., Congia,M., Cauli,A., Caccavale,R., Paroli,M., Di Franco,M., Tuosto,L., Sorrentino,R., D'Abramo,M. and Fiorillo,M.T.
   ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes
   Int J Mol Sci24, PubMed  Europe PubMed DOI  M
2022
10. Arya,R., Maben,Z., Rane,D., Ali,A. and Stern,L.J.
    Phenylsulfamoyl Benzoic Acid Inhibitor of ERAP2 with a Novel Mode of Inhibition
    ACS Chem Biol17, 1756-1768. PubMed  Europe PubMed DOI  I
11. Camberlein,V., Fleau,C., Sierocki,P., Li,L., Gealageas,R., Bosc,D., Guillaume,V., Warenghem,S., Leroux,F., Rosell,M., Cheng,K., Medve,L., Prigent,M., Decanter,M., Piveteau,C., Biela,A., Eveque,M., Dumont,J., Mpakali,A., Giastas,P., Herledan,A., Couturier,C., Haupenthal,J., Lesire,L., Hirsch,A.K.H., Deprez,B., Stratikos,E., Bouvier,M. and Deprez-Poulain,R.
    Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target-Guided Synthesis
    Angew Chem Int Ed Engl61, e202203560-e202203560. PubMed  Europe PubMed DOI
12. Kusnierczyk,P.
    To Be or Not to Be: The Case of Endoplasmic Reticulum Aminopeptidase 2
    Front Immunol13, 902567-902567. PubMed  Europe PubMed DOI  V
13. Martin-Esteban,A., Rodriguez,J.C., Peske,D., Lopez de Castro,J.A., Shastri,N. and Sadegh-Nasseri,S.
    The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
    Front Immunol13, 1066483-1066483. PubMed  Europe PubMed DOI
14. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.
    The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
    Front Immunol13, 1002375-1002375. PubMed  Europe PubMed DOI  M
15. Mattorre,B., Caristi,S., Donato,S., Volpe,E., Faiella,M., Paiardini,A., Sorrentino,R. and Paladini,F.
    A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation
    Int J Mol Sci23, PubMed  Europe PubMed DOI  M
16. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.
    The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
    Front Immunol13, 1002375- PubMed  Europe PubMed
17. Papakyriakou,A., Mpakali,A. and Stratikos,E.
    Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
    Front Immunol13, 863529-863529. PubMed  Europe PubMed DOI
18. Yu,P., Luo,S., Cai,J., Li,J. and Peng,C.
    ERAP2 as a potential biomarker for predicting gemcitabine response in patients with pancreatic cancer
    Aging (Albany NY)14, 7941-7958. PubMed  Europe PubMed DOI  K
2021
19. D'Amico,S., Tempora,P., Lucarini,V., Melaiu,O., Gaspari,S., Algeri,M. and Fruci,D.
    ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19?
    Int J Mol Sci22, PubMed  Europe PubMed DOI  V
20. Ebrazeh,M., Ezzatifar,F., Torkamandi,S., Mohammadi,F.S., Salimifard,S., Gowhari Shabgah,A., Hemmatzadeh,M., Aslani,S., Babaie,F., Jadidi-Niaragh,F., Gholizadeh Navashenaq,J. and Mohammadi,H.
    Association of the genetic variants in the endoplasmic reticulum aminopeptidase 2 gene with ankylosing spondylitis susceptibility
    Int J Rheum Dis PubMed  Europe PubMed DOI
21. Gao,S., Xu,T., Mao,C., Cheng,J., Xun,C., Liang,W. and Sheng,W.
    Lack of Associations between Endoplasmic Reticulum Aminopeptidase 2 Gene Polymorphisms and Ankylosing Spondylitis: A Meta-analysis with Trial Sequential Analysis
    Immunol Invest1-12. PubMed  Europe PubMed DOI
22. Gelfman,S., Monnet,D., Ligocki,A.J., Tabary,T., Moscati,A., Bai,X., Freudenberg,J., Cooper,B., Kosmicki,J.A., Wolf,S., Ferreira,M.A.R., Overton,J., Weyne,J., Stahl,E.A., Baras,A., Romano,C., Cohen,J.H.M., Coppola,G. and Brezin,A.
    ERAP1, ERAP2, and Two Copies of HLA-Aw19 Alleles Increase the Risk for Birdshot Chorioretinopathy in HLA-A29 Carriers
    Invest Ophthalmol Vis Sci62, 3-3. PubMed  Europe PubMed DOI
23. Lospinoso,K., Dozmorov,M., El Fawal,N., Raghu,R., Chae,W.J. and Lee,E.D.
    Overexpression of ERAP2N in Human Trophoblast Cells Promotes Cell Death
    Int J Mol Sci22, PubMed  Europe PubMed DOI
24. Yang,Z., Tian,H., Bie,F., Xu,J., Zhou,Z., Yang,J., Li,R., Peng,Y., Bai,G., Tian,Y., Chen,Y., Liu,L., Fan,T., Xiao,C., Zheng,Y., Zheng,B., Wang,J., Li,C., Gao,S. and He,J.
    ERAP2 Is Associated With Immune Infiltration and Predicts Favorable Prognosis in SqCLC
    Front Immunol12, 788985-788985. PubMed  Europe PubMed DOI
2020
25. Li,C., Li,Y., Yan,Z., Dai,S., Liu,S., Wang,X., Wang,J., Zhang,X., Shi,L. and Yao,Y.
    Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population
    BMC Cancer20, 341-341. PubMed  Europe PubMed DOI  M
26. Lorente,E., Fontela,M.G., Barnea,E., Martin-Galiano,A.J., Mir,C., Galocha,B., Admon,A., Lauzurica,P. and Lopez,D.
    Modulation of natural HLA-B*27:05 ligandome by ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 2 (ERAP2)
    Mol Cell Proteomics19, 994-1004. PubMed  Europe PubMed DOI
27. Niepieklo-Miniewska,W., Matusiak,L., Narbutt,J., Lesiak,A., Kuna,P., Wisniewski,A., Piekarska,K., Nowak,I. and Kusnierczyk,P.
    Synergy of endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) polymorphisms in atopic dermatitis: Effects on disease prevalence
    Hum Immunol PubMed  Europe PubMed DOI
28. Paladini,F., Fiorillo,M.T., Tedeschi,V., Mattorre,B. and Sorrentino,R.
    The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease
    Front Immunol11, 1576-1576. PubMed  Europe PubMed
29. Zhang,S., Liu,S., Liu,N., Li,C., Wang,H., Shi,L., Zhang,X., Bao,L., Yao,Y. and Shi,L.
    Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese
    Front Genet11, 566190-566190. PubMed  Europe PubMed
2019
30. Georgiadis,D., Mpakali,A., Koumantou,D. and Stratikos,E.
    Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application
    Curr Med Chem26, 2715-2729. PubMed  Europe PubMed DOI  I
31. Hanson,A.L., Morton,C.J., Parker,M.W., Bessette,D. and Kenna,T.J.
    The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease
    Hum Immunol80, 281-289. PubMed  Europe PubMed DOI
32. Saulle,I., Ibba,S.V., Torretta,E., Vittori,C., Fenizia,C., Piancone,F., Minisci,D., Lori,E.M., Trabattoni,D., Gelfi,C., Clerici,M. and Biasin,M.
    Endoplasmic reticulum associated aminopeptidase 2 (ERAP2) is released in the secretome of activated MDMs and reduces in vitro HIV-1 infection
    Front Immunol10, 1648-1648. PubMed  Europe PubMed DOI
2018
33. Kuiper,J.J., van Setten,J., Devall,M., Cretu-Stancu,M., Hiddingh,S., Ophoff,R.A., Missotten,T.O.A.R., van Velthoven,M., Den Hollander,A.I., Hoyng,C.B., James,E., Reeves,E., Cordero-Coma,M., Fonollosa,A., Adán,A., Martín,J., Koeleman,B.P., de Boer,J.H., Pulit,S.L., Márquez,A. and Radstake,T.R.D.J.
    Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis
    Hum Mol Genet27, 4333-4343. DOI
34. Lim,Y.W., Chen-Harris,H., Mayba,O., Lianoglou,S., Wuster,A., Bhangale,T., Khan,Z., Mariathasan,S., Daemen,A., Reeder,J., Haverty,P.M., Forrest,W.F., Brauer,M., Mellman,I. and Albert,M.L.
    Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration
    Proc Natl Acad Sci U S A115, E11701-E11710. DOI
35. Warthan,M.D., Washington,S.L., Franzese,S.E., Ramus,R.M., Kim,K.R., York,T.P., Stratikos,E., Strauss JF 3rd and Lee,E.D.
    The role of endoplasmic reticulum aminopeptidase 2 in modulating immune detection of choriocarcinoma
    Biol Reprod98, 309-322. PubMed  Europe PubMed DOI  M
36. Ye,C.J., Chen,J., Villani,A.C., Gate,R.E., Subramaniam,M., Bhangale,T., Lee,M.N., Raj,T., Raychowdhury,R., Li,W., Rogel,N., Simmons,S., Imboywa,S.H., Chipendo,P.I., McCabe,C., Lee,M.H., Frohlich,I.Y., Stranger,B.E., De,J.a., Regev,A., Behrens,T. and Hacohen,N.
    Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection
    Genome Res28, 1812-1825. DOI
2017
37. Lee,E.D.
    Endoplasmic reticulum aminopeptidase 2, a common immunological link to adverse pregnancy outcomes and cancer clearance?
    Placenta56, 40-43. PubMed  Europe PubMed DOI  M
2016
38. Pedersen,N.C., Dhanota,J.K. and Liu,H.
    Polymorphisms in ERAP1 and ERAP2 are shared by Caninae and segregate within and between random- and pure-breeds of dogs
    Vet Immunol Immunopathol179, 46-57. PubMed  Europe PubMed DOI  M
2015
39. Mpakali,A., Giastas,P., Mathioudakis,N., Mavridis,I.M., Saridakis,E. and Stratikos,E.
    Structural basis for antigenic peptide recognition and processing by endoplasmic reticulum (ER) aminopeptidase 2
    J Biol Chem290, 26021-26032. PubMed  Europe PubMed DOI  S
40. Robinson,P.C., Costello,M.E., Leo,P., Bradbury,L.A., Hollis,K., Cortes,A., Lee,S., Joo,K.B., Shim,S.C., Weisman,M., Ward,M., Zhou,X., Garchon,H.J., Chiocchia,G., Nossent,J., Lie,B.A., Førre,Ø., Tuomilehto,J., Laiho,K., Jiang,L., Liu,Y., Wu,X., Elewaut,D., Burgos-Vargas,R., Gensler,L.S., Stebbings,S., Haroon,N., Mulero,J., Fernandez-Sueiro,J.L., Gonzalez-Gay,M.A., Lopez-Larrea,C., Bowness,P., Gafney,K., Gaston,J.S., Gladman,D.D., Rahman,P., Maksymowych,W.P., Xu,H., van,d., Chou,C.T., Valle-Oñate,R., Romero-Sánchez,M.C., Hansen,I.M., Pimentel-Santos,F.M., Inman,R.D., Martin,J., Breban,M., Evans,D., Reveille,J.D., Kim,T.H., Wordsworth,B.P. and Brown,M.A.
    ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients
    Ann Rheum Dis74, 1627-1629. DOI
2014
41. [YEAR:15-7-2014]Evnouchidou,I., Weimershaus,M., Saveanu,L. and van,E.P.
    ERAP1-ERAP2 dimerization increases peptide-trimming efficiency
    J Immunol193, 901-908. PubMed  Europe PubMed
42. Hitzerd,S.M., Verbrugge,S.E., Ossenkoppele,G., Jansen,G. and Peters,G.J.
    Positioning of aminopeptidase inhibitors in next generation cancer therapy
    Amino Acids46, 793-808. PubMed  Europe PubMed DOI  I
43. Kuiper,J.J., van Setten,J., Ripke,S., van 't Slot,R., Mulder,F., Missotten,T., Baarsma,G.S., Francioli,L.C., Pulit,S.L., De Kovel,C.G.F., Ten Dam-Van Loon,N., Den Hollander,A.I., Huis in het Veld,P., Hoyng,C.B., Cordero-Coma,M., Martín,J., Llorenç,V., Arya,B., Thomas,D., Bakker,S.C., Ophoff,R.A., Rothova,A., De Bakker,P.I.W., Mutis,T. and Koeleman,B.P.C.
    A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy
    Hum Mol Genet23, 6081-6087. DOI
2013
44. Biasin,M., Sironi,M., Saulle,I., De Luca,M., la Rosa,F., Cagliani,R., Forni,D., Agliardi,C., Caputo,S.L., Mazzotta,F., Trabattoni,D., Macias,J., Pineda,J.A., Caruz,A. and Clerici,M.
    Endoplasmic reticulum aminopeptidase 2 haplotypes play a role in modulating susceptibility to HIV infection
    AIDS27, 1697-1706. PubMed  Europe PubMed DOI  M
45. Gadalla,S.E., Ojemalm,K., Vasquez,P.L., Nilsson,I., Ericsson,C., Zhao,J. and Nister,M.
    EpCAM associates with endoplasmic reticulum aminopeptidase 2 (ERAP2) in breast cancer cells
    Biochem Biophys Res Commun439, 203-208. PubMed  Europe PubMed DOI
2012
46. Ascher,D.B., Polekhina,G. and Parker,M.W.
    Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2
    Acta Crystallogr Sect F Struct Biol Cryst Commun68, 468-471. PubMed  Europe PubMed DOI  I
47. Birtley,J.R., Saridakis,E., Stratikos,E. and Mavridis,I.M.
    The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing
    Biochemistry51, 286-295. PubMed  Europe PubMed DOI  S
48. Evnouchidou,I., Birtley,J., Seregin,S., Papakyriakou,A., Zervoudi,E., Samiotaki,M., Panayotou,G., Giastas,P., Petrakis,O., Georgiadis,D., Amalfitano,A., Saridakis,E., Mavridis,I.M. and Stratikos,E.
    A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing
    J Immunol189, 2383-2392. PubMed  Europe PubMed DOI  M  P
49. van Endert,P. and Saveanu,L.
    Endoplasmic reticulum aminopeptidase 2
    [ISSN:978-0-12-407744-7]3, 434-438. DOI
2011
50. Harvey,D., Pointon,J.J., Karaderi,T., Appleton,L.H., Farrar,C. and Wordsworth,B.P.
    A common functional variant of endoplasmic reticulum aminopeptidase 2 (ERAP2) that reduces major histocompatibility complex class I expression is not associated with ankylosing spondylitis
    Rheumatology (Oxford)50, 1720-1721. PubMed  Europe PubMed DOI  M
2010
51. Andres,A.M., Dennis,M.Y., Kretzschmar,W.W., Cannons,J.L., Lee-Lin,S.Q., Hurle,B., Schwartzberg,P.L., Williamson,S.H., Bustamante,C.D., Nielsen,R., Clark,A.G. and Green,E.D.
    Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation
    PLoS Genet6, e1001157-e1001157. PubMed  Europe PubMed DOI  M
52. Cagliani,R., Riva,S., Biasin,M., Fumagalli,M., Pozzoli,U., Lo Caputo,S., Mazzotta,F., Piacentini,L., Bresolin,N., Clerici,M. and Sironi,M.
    Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection
    Hum Mol Genet19, 4705-4714. PubMed  Europe PubMed DOI  M
53. Forloni,M., Albini,S., Limongi,M.Z., Cifaldi,L., Boldrini,R., Nicotra,M.R., Giannini,G., Natali,P.G., Giacomini,P. and Fruci,D.
    NF-kappaB, and not MYCN, regulates MHC class I and endoplasmic reticulum aminopeptidases in human neuroblastoma cells
    Cancer Res70, 916-924. PubMed  Europe PubMed DOI
54. Haroon,N. and Inman,R.D.
    Endoplasmic reticulum aminopeptidases: biology and pathogenic potential
    Nat Rev Rheumatol6, 461-467. PubMed  Europe PubMed DOI
55. Tsui,F.W., Haroon,N., Reveille,J.D., Rahman,P., Chiu,B., Tsui,H.W. and Inman,R.D.
    Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis
    Ann Rheum Dis69, 733-736. PubMed  Europe PubMed DOI  M
2009
56. Evnouchidou,I., Papakyriakou,A. and Stratikos,E.
    A new role for Zn(II) aminopeptidases: antigenic peptide generation and destruction
    Curr Pharm Des15, 3656-3670. PubMed  Europe PubMed DOI
57. Johnson,M.P., Roten,L.T., Dyer,T.D., East,C.E., Forsmo,S., Blangero,J., Brennecke,S.P., Austgulen,R. and Moses,E.K.
    The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations
    Hum Genet126, 655-666. PubMed  Europe PubMed DOI  M
2008
58. Fruci,D., Giacomini,P., Nicotra,M.R., Forloni,M., Fraioli,R., Saveanu,L., vanEndert,P. and Natali,P.G.
    Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues
    J Cell Physiol216, 742-749. PubMed  Europe PubMed DOI
2006
59. Fruci,D., Ferracuti,S., Limongi,M.Z., Cunsolo,V., Giorda,E., Fraioli,R., Sibilio,L., Carroll,O., Hattori,A., vanEndert,P.M. and Giacomini,P.
    Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines
    J Immunol176, 4869-4879. PubMed  Europe PubMed
2005
60. Saveanu,L., Carroll,O., Hassainya,Y. and van Endert,P.
    Complexity, contradictions, and conundrums: studying post-proteasomal proteolysis in HLA class I antigen presentation
    Immunol Rev207, 42-59. PubMed  Europe PubMed DOI
61. Saveanu,L., Carroll,O., Lindo,V., Del Val,M., Lopez,D., Lepelletier,Y., Greer,F., Schomburg,L., Fruci,D., Niedermann,G. and van Endert,P.M.
    Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum
    Nat Immunol6, 689-697. PubMed  Europe PubMed DOI
62. Tanioka,T., Hattori,A., Mizutani,S. and Tsujimoto,M.
    Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma
    FEBS J272, 916-928. PubMed  Europe PubMed DOI
63. Tsujimoto,M. and Hattori,A.
    The oxytocinase subfamily of M1 aminopeptidases
    Biochim Biophys Acta1751, 9-18. PubMed  Europe PubMed DOI
2003
64. [YEAR:22-8-2003]Tanioka,T., Hattori,A., Masuda,S., Nomura,Y., Nakayama,H., Mizutani,S. and Tsujimoto,M.
    Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases
    J Biol Chem278, 32275-32283. PubMed  Europe PubMed DOI