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Literature for peptidase M01.004: leukotriene A4 hydrolase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, M Mutation, P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Zhou,X., Wang,S., Yang,X., Zhang,X., Ma,Z., Du,L. and Li,M.<br>Optical Control of Leukotriene A4 Hydrolase Using Photoswitchable Inhibitors<br>J Med Chem (2025) PubMed  Europe PubMed DOI
    2. 2024
  2. Thoma,G., Miltz,W., Srinivas,H., Penno,C.A., Kiffe,M., Gajewska,M., Klein,K., Evans,A., Beerli,C. and Rohn,T.A.<br>Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor<br>J Med Chem (2024) 67, 5093-5108. PubMed  Europe PubMed DOI
  3. Xu,X., Li,J.D., Green,T.J., Wilson,L., Genschmer,K., Russell,D., Blalock,J.E. and Gaggar,A.<br>Neutrophil elastase-dependent cleavage of LTA4H alters its aminopeptidase activity in cystic fibrosis<br>Eur Respir J (2024) 63 PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2023
  4. Adams,J.M., Rege,S.V., Liu,A.T., Vu,N.V., Raina,S., Kirsher,D.Y., Nguyen,A.L., Harish,R., Szoke,B., Leone,D.P., Czirr,E., Braithwaite,S. and Kerrisk Campbell,M.<br>Leukotriene A4 hydrolase inhibition improves age-related cognitive decline via modulation of synaptic function<br>Sci Adv (2023) 9, eadf8764-eadf8764. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Cai,Y., Mu,X., Li,G. and Xu,D.<br>Quantum Mechanical/Molecular Mechanical Elucidation of the Catalytic Mechanism of Leukotriene A4 Hydrolase as an Epoxidase<br>J Phys Chem B (2023) 127, 10338-10350. PubMed  Europe PubMed DOI
  6. Kumar,S.S., Solomon,R., Gautam,P., Inbaraj,L.R., Sivadasan,A., Michael,J.S., Karthik,R., Varghese,G.M., Christudass,C.S., Samuel,P. and Manesh,A.<br>Leukotriene A4 hydrolase (LTA4H rs17525495) gene polymorphisms and paradoxical reactions in extrapulmonary tuberculosis<br>Sci Rep (2023) 13, 3746-3746. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2022
  7. Canyelles-Nino,M., Gonzalez-Lafont,A. and Lluch,J.M.<br>Theoretical Characterization of the Step-by-Step Mechanism of Conversion of Leukotriene A4 to Leukotriene B4 Catalysed by the Enzyme Leukotriene A4 Hydrolase<br>Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  8. Fang,M., Tang,X., Zhang,J., Liao,Z., Wang,G., Cheng,R., Zhang,Z., Zhao,H., Wang,J., Tan,Z., Kamau,P.M., Lu,Q., Liu,Q., Deng,G. and Lai,R.<br>An inhibitor of leukotriene-A4 hydrolase from bat salivary glands facilitates virus infection<br>Proc Natl Acad Sci U S A (2022) 119, e2110647119-e2110647119. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2021
  9. Rohn,T.A., Numao,S., Otto,H., Loesche,C. and Thoma,G.<br>Drug discovery strategies for novel leukotriene A4 hydrolase inhibitors<br>Expert Opin Drug Discov (2021) , 1-13. PubMed  Europe PubMed DOI  V
  10. Whitworth,L., Coxon,J., van Laarhoven,A., Thuong,N.T.T., Dian,S., Alisjahbana,B., Ganiem,A.R., van Crevel,R., Thwaites,G.E., Troll,M., Edelstein,P.H., Sewell,R. and Ramakrishnan,L.<br>A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis<br>elife (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2020
  11. Uzawa,H., Kohno,D., Koga,T., Sasaki,T., Fukunaka,A., Okuno,T., Jo-Watanabe,A., Kazuno,S., Miyatsuka,T., Kitamura,T., Fujitani,Y., Watada,H., Saeki,K. and Yokomizo,T.<br>Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis<br>FASEB J (2020) 34, 13949-13958. PubMed  Europe PubMed DOI  K
    12. 2019
  12. Lee,K.H., Petruncio,G., Shim,A., Burdick,M., Zhang,Z., Shim,Y.M., Noble,S.M. and Paige,M.<br>Effect of modifier structure on the activation of leukotriene A4 hydrolase aminopeptidase activity<br>J Med Chem (2019) 62, 10605-10616. PubMed  Europe PubMed DOI  S
    13. 2018
  13. Vo,T.T.L., Jang,W.J. and Jeong,C.H.<br>Leukotriene A4 hydrolase: an emerging target of natural products for cancer chemoprevention and chemotherapy<br>Ann N Y Acad Sci (2018) 1431, 3-13. PubMed  Europe PubMed DOI
    14. 2017
  14. Low,C.M., Akthar,S., Patel,D.F., Loser,S., Wong,C.T., Jackson,P.L., Blalock,J.E., Hare,S.A., Lloyd,C.M. and Snelgrove,R.J.<br>The development of novel LTA4H modulators to selectively target LTB4 generation<br>Sci Rep (2017) 7, 44449-44449. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Numao,S., Hasler,F., Laguerre,C., Srinivas,H., Wack,N., Jager,P., Schmid,A., Osmont,A., Rothlisberger,P., Houguenade,J., Bergsdorf,C., Dawson,J., Carte,N., Hofmann,A., Markert,C., Hardaker,L., Billich,A., Wolf,R.M., Penno,C.A., Bollbuck,B., Miltz,W. and Rohn,T.A.<br>Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors<br>Sci Rep (2017) 7, 13591-13591. PubMed  Europe PubMed DOI  PMC  EPMC  I
  16. Stsiapanava,A., Samuelsson,B. and Haeggstrom,J.Z.<br>Capturing LTA4 hydrolase in action: insights to the chemistry and dynamics of chemotactic LTB4 synthesis<br>Proc Natl Acad Sci U S A (2017) 114, 9689-9694. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Torres,M.J., Fierro,A., Pessoa-Mahana,C.D., Romero-Parra,J., Cabrera,G. and Faundez,M.<br>Effect of alpha lipoic acid on leukotriene A4 hydrolase<br>Eur J Pharmacol (2017) 799, 41-47. PubMed  Europe PubMed DOI  I
  18. Zhang,F., Wu,D., Wang,G.-L., Hou,S., Ou-Yang,P., Huang,J. and Xu,X.-Y.<br>Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A4 hydrolase aminopeptidase inhibitors<br>Chin Chem Lett (2017) 28, 1044-1048. DOI  I
    19. 2016
  19. Wittmann,S.K., Kalinowsky,L., Kramer,J.S., Bloecher,R., Knapp,S., Steinhilber,D., Pogoryelov,D., Proschak,E. and Heering,J.<br>Thermodynamic properties of leukotriene A4 hydrolase inhibitors<br>Bioorg Med Chem (2016) 24, 5243-5248. PubMed  Europe PubMed DOI  I
  20. Xiao,Q., Dong,N., Yao,X., Wu,D., Lu,Y., Mao,F., Zhu,J., Li,J., Huang,J., Chen,A., Huang,L., Wang,X., Yang,G., He,G., Xu,Y. and Lu,W.<br>Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H<br>Sci Rep (2016) 6, 25298-25298. PubMed  Europe PubMed DOI  PMC  EPMC  I
    21. 2015
  21. Paz,P.B., Vega-Hissi,E.G., Andrada,M.F., Estrada,M.R. and Garro Martinez,J.C.<br>Quantitative structure activity relationship and binding investigation of N-alkyl glycine amides as inhibitors of leukotriene A4 hydrolase<br>Med Chem Res (2015) 24, 496-504. DOI  I
    22. 2014
  22. Barchuk,W., Lambert,J., Fuhr,R., Jiang,J.Z., Bertelsen,K., Fourie,A., Liu,X., Silkoff,P.E., Barnathan,E.S. and Thurmond,R.<br>Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma<br>Pulm Pharmacol Ther (2014) 29, 15-23. PubMed  Europe PubMed DOI  I
  23. Byzia,A., Haeggstrom,J.Z., Salvesen,G.S. and Drag,M.<br>A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids<br>Amino Acids (2014) 46, 1313-1320. PubMed  Europe PubMed DOI  P
  24. Hitzerd,S.M., Verbrugge,S.E., Ossenkoppele,G., Jansen,G. and Peters,G.J.<br>Positioning of aminopeptidase inhibitors in next generation cancer therapy<br>Amino Acids (2014) 46, 793-808. PubMed  Europe PubMed DOI  I
  25. Stsiapanava,A., Tholander,F., Kumar,R.B., Qureshi,A.A., Niegowski,D., Hasan,M., Thunnissen,M., Haeggstrom,J.Z. and Rinaldo-Matthis,A.<br>Product formation controlled by substrate dynamics in leukotriene A4 hydrolase<br>Biochim Biophys Acta (2014) 1844, 439-446. PubMed  Europe PubMed DOI  S
  26. Stsiapanava,A., Olsson,U., Wan,M., Kleinschmidt,T., Rutishauser,D., Zubarev,R.A., Samuelsson,B., Rinaldo-Matthis,A. and Haeggstrom,J.Z.<br>Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor<br>Proc Natl Acad Sci U S A (2014) 111, 4227-4232. PubMed  Europe PubMed DOI  S  I
    27. 2013
  27. Caliskan,B. and Banoglu,E.<br>Overview of recent drug discovery approaches for new generation leukotriene A4 hydrolase inhibitors<br>Expert Opin Drug Discov (2013) 8, 49-63. PubMed  Europe PubMed DOI  V  I
  28. Eccles,W., Blevitt,J.M., Booker,J.N., Chrovian,C.C., Crawford,S., de Leon,A.R., Deng,X., Fourie,A.M., Grice,C.A., Herman,K., Karlsson,L., Kearney,A.M., Lee-Dutra,A., Liang,J., Luna,R., Pippel,D., Rao,N., Riley,J.P., Santillan,A., Savall,B., Tanis,V.M., Xue,X. and Young,A.L.<br>Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase<br>Bioorg Med Chem Lett (2013) 23, 811-815. PubMed  Europe PubMed DOI  I
  29. Meng,H., Liu,Y., Zhai,Y. and Lai,L.<br>Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase<br>Eur J Med Chem (2013) 59, 160-167. PubMed  Europe PubMed DOI  I
  30. Poras,H., Duquesnoy,S., Fournie-Zaluski,M.C., Ratinaud-Giraud,C., Roques,B.P. and Ouimet,T.<br>A sensitive fluorigenic substrate for selective in vitro and in vivo assay of leukotriene A4 hydrolase activity<br>Anal Biochem (2013) 441, 152-161. PubMed  Europe PubMed DOI  A
  31. Thangapandian,S., John,S., Son,M., Arulalapperumal,V. and Lee,K.W.<br>Development of predictive quantitative structure-activity relationship model and its application in the discovery of human leukotriene A4 hydrolase inhibitors<br>Future Med Chem (2013) 5, 27-40. PubMed  Europe PubMed DOI  I
  32. Zhao,J., Goldberg,J. and Vaccarino,V.<br>Leukotriene A4 hydrolase haplotype, diet and atherosclerosis: a twin study<br>Atherosclerosis (2013) 226, 238-244. PubMed  Europe PubMed DOI  M
    33. 2012
  33. Haeggstrom,J.Z.<br>Leukotriene A4 hydrolase<br>[ISSN:978-0-12-407744-7] (2012) 3, 468-472. DOI
  34. Tanis,V.M., Bacani,G.M., Blevitt,J.M., Chrovian,C.C., Crawford,S., De Leon,A., Fourie,A.M., Gomez,L., Grice,C.A., Herman,K., Kearney,A.M., Landry-Bayle,A.M., Lee-Dutra,A., Nelson,J., Riley,J.P., Santillan,A., Jr., Wiener,J.J., Xue,X. and Young,A.L.<br>Azabenzthiazole inhibitors of leukotriene A4 hydrolase<br>Bioorg Med Chem Lett (2012) 22, 7504-7511. PubMed  Europe PubMed DOI  I
    35. 2011
  35. De Oliveira,E.O., Wang,K., Kong,H.S., Kim,S., Miessau,M., Snelgrove,R.J., Shim,Y.M. and Paige,M.<br>Effect of the leukotriene A4 hydrolase aminopeptidase augmentor 4-methoxydiphenylmethane in a pre-clinical model of pulmonary emphysema<br>Bioorg Med Chem Lett (2011) 21, 6746-6750. PubMed  Europe PubMed DOI
  36. Sarker,M.A., Matsuda,S., Mizutani,O., Rao,S., Migita,K., Goto-Yamamoto,N., Iefuji,H. and Nishimura,T.<br>Purification and characterization of porcine skeletal muscle aminopeptidase T, a novel metallopeptidase homologous to leukotriene A4 hydrolase<br>Biosci Biotechnol Biochem (2011) 75, 1154-1159. PubMed  Europe PubMed DOI
  37. Snelgrove,R.J.<br>Leukotriene A4 hydrolase: an anti-inflammatory role for a proinflammatory enzyme<br>Thorax (2011) 66, 550-551. PubMed  Europe PubMed DOI
  38. Thangapandian,S., John,S., Sakkiah,S. and Lee,K.W.<br>Molecular docking and pharmacophore filtering in the discovery of dual-inhibitors for human leukotriene A4 hydrolase and leukotriene C4 synthase<br>J Chem Inf Model (2011) 51, 33-44. PubMed  Europe PubMed DOI  I
  39. Thangapandian,S., John,S., Sakkiah,S. and Lee,K.W.<br>Pharmacophore-based virtual screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors<br>Eur J Med Chem (2011) 46, 1593-1603. PubMed  Europe PubMed DOI  I
    40. 2010
  40. Jiang,X., Zhou,L., Wu,Y., Wei,D., Sun,C., Jia,J., Liu,Y. and Lai,L.<br>Modulating the substrate specificity of LTA4H aminopeptidase by using chemical compounds and small-molecule-guided mutagenesis<br>Chembiochem (2010) 11, 1120-1128. PubMed  Europe PubMed DOI  P
  41. Oi,N., Jeong,C.H., Nadas,J., Cho,Y.Y., Pugliese,A., Bode,A.M. and Dong,Z.<br>Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A4 hydrolase<br>Cancer Res (2010) 70, 9755-9764. PubMed  Europe PubMed DOI  I
  42. Rao,N.L., Riley,J.P., Banie,H., Xue,X., Sun,B., Crawford,S., Lundeen,K.A., Yu,F., Karlsson,L., Fourie,A.M. and Dunford,P.J.<br>Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness<br>Am J Respir Crit Care Med (2010) 181, 899-907. PubMed  Europe PubMed DOI  I
  43. Rinaldo-Matthis,A. and Haeggstrom,J.Z.<br>Structures and mechanisms of enzymes in the leukotriene cascade<br>Biochimie (2010) 92, 676-681. PubMed  Europe PubMed DOI
  44. Sandanayaka,V., Mamat,B., Mishra,R.K., Winger,J., Krohn,M., Zhou,L.M., Keyvan,M., Enache,L., Sullins,D., Onua,E., Zhang,J., Halldorsdottir,G., Sigthorsdottir,H., Thorlaksdottir,A., Sigthorsson,G., Thorsteinnsdottir,M., Davies,D.R., Stewart,L.J., Zembower,D.E., Andresson,T., Kiselyov,A.S., Singh,J. and Gurney,M.E.<br>Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis<br>J Med Chem (2010) 53, 573-585. PubMed  Europe PubMed DOI  I
  45. Sandanayaka,V., Mamat,B., Bhagat,N., Bedell,L., Halldorsdottir,G., Sigthorsdottir,H., Andresson,T., Kiselyov,A., Gurney,M. and Singh,J.<br>Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds<br>Bioorg Med Chem Lett (2010) 20, 2851-2854. PubMed  Europe PubMed DOI  I
  46. Snelgrove,R.J., Jackson,P.L., Hardison,M.T., Noerager,B.D., Kinloch,A., Gaggar,A., Shastry,S., Rowe,S.M., Shim,Y.M., Hussell,T. and Blalock,J.E.<br>A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation<br>Science (2010) 330, 90-94. PubMed  Europe PubMed DOI
  47. Sonawane,L.V. and Bari,S.B.<br>QSAR, docking studies and pharmacophore identification of phenylmethyl phenoxy propyl amino propanoic acid derivatives as leukotriene A4 hydrolase inhibitors<br>Yao Xue Xue Bao (2010) 45, 615-623. PubMed  Europe PubMed  I
  48. Tholander,F., Roques,B.P., Fournie-Zaluski,M.C., Thunnissen,M.M. and Haeggstrom,J.Z.<br>Crystal structure of leukotriene A4 hydrolase in complex with kelatorphan, implications for design of zinc metallopeptidase inhibitors<br>FEBS Lett (2010) 584, 3446-3451. PubMed  Europe PubMed DOI  S  I
    49. 2009
  49. Davies,D.R., Mamat,B., Magnusson,O.T., Christensen,J., Haraldsson,M.H., Mishra,R., Pease,B., Hansen,E., Singh,J., Zembower,D., Kim,H., Kiselyov,A.S., Burgin,A.B., Gurney,M.E. and Stewart,L.J.<br>Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography<br>J Med Chem (2009) 52, 4694-4715. PubMed  Europe PubMed DOI  PMC  EPMC  I
  50. Enomoto,H., Morikawa,Y., Miyake,Y., Tsuji,F., Mizuchi,M., Suhara,H., Fujimura,K., Horiuchi,M. and Ban,M.<br>Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors<br>Bioorg Med Chem Lett (2009) 19, 442-446. PubMed  Europe PubMed DOI  I
  51. Fourie,A.M.<br>Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase<br>Curr Opin Investig Drugs (2009) 10, 1173-1182. PubMed  Europe PubMed  V  I
  52. Jeong,C.H., Bode,A.M., Pugliese,A., Cho,Y.Y., Kim,H.G., Shim,J.H., Jeon,Y.J., Li,H., Jiang,H. and Dong,Z.<br>[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase<br>Cancer Res (2009) 69, 5584-5591. PubMed  Europe PubMed DOI  I
  53. Zhao,J., Quyyumi,A.A., Patel,R., Zafari,A.M., Veledar,E., Onufrak,S., Shallenberger,L.H., Jones,L. and Vaccarino,V.<br>Sex-specific association of depression and a haplotype in leukotriene A4 hydrolase gene<br>Psychosom Med (2009) 71, 691-696. PubMed  Europe PubMed DOI  M
    54. 2008
  54. Enomoto,H., Morikawa,Y., Miyake,Y., Tsuji,F., Mizuchi,M., Suhara,H., Fujimura,K., Horiuchi,M. and Ban,M.<br>Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors<br>Bioorg Med Chem Lett (2008) 18, 4529-4532. PubMed  Europe PubMed DOI  I
  55. Grice,C.A., Tays,K.L., Savall,B.M., Wei,J., Butler,C.R., Axe,F.U., Bembenek,S.D., Fourie,A.M., Dunford,P.J., Lundeen,K., Coles,F., Xue,X., Riley,J.P., Williams,K.N., Karlsson,L. and Edwards,J.P.<br>Identification of a potent, selective, and orally active leukotriene A4 hydrolase inhibitor with anti-inflammatory activity<br>J Med Chem (2008) 51, 4150-4169. PubMed  Europe PubMed DOI  I
  56. Grice,C.A. and Gomez,L.<br>Current status of leukotriene A4 hydrolase inhibitors<br>Expert Opin Ther Pat (2008) 18, 1333-1350. DOI  I
  57. Jiang,X., Zhou,L., Wei,D., Meng,H., Liu,Y. and Lai,L.<br>Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives<br>Bioorg Med Chem Lett (2008) 18, 6549-6552. PubMed  Europe PubMed DOI  I
  58. Khim,S.K., Bauman,J., Evans,J., Freeman,B., King,B., Kirkland,T., Kochanny,M., Lentz,D., Liang,A., Mendoza,L., Phillips,G., Tseng,J.L., Wei,R.G., Ye,H., Yu,L., Parkinson,J. and Guilford,W.J.<br>Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors<br>Bioorg Med Chem Lett (2008) 18, 3895-3898. PubMed  Europe PubMed DOI  I
  59. Kirkland,T.A., Adler,M., Bauman,J.G., Chen,M., Haeggstrom,J.Z., King,B., Kochanny,M.J., Liang,A.M., Mendoza,L., Phillips,G.B., Thunnissen,M., Trinh,L., Whitlow,M., Ye,B., Ye,H., Parkinson,J. and Guilford,W.J.<br>Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase<br>Bioorg Med Chem (2008) 16, 4963-4983. PubMed  Europe PubMed DOI  I
  60. Tholander,F., Muroya,A., Roques,B.P., Fournie-Zaluski,M.C., Thunnissen,M.M. and Haeggstrom,J.Z.<br>Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design<br>Chem Biol (2008) 15, 920-929. PubMed  Europe PubMed DOI
  61. Whittle,B.J., Varga,C., Berko,A., Horvath,K., Posa,A., Riley,J.P., Lundeen,K.A., Fourie,A.M. and Dunford,P.J.<br>Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase<br>Br J Pharmacol (2008) 153, 983-991. PubMed  Europe PubMed DOI  PMC  EPMC  I
  62. Ye,B., Bauman,J., Chen,M., Davey,D., Khim,S.K., King,B., Kirkland,T., Kochanny,M., Liang,A., Lentz,D., May,K., Mendoza,L., Phillips,G., Selchau,V., Schlyer,S., Tseng,J.L., Wei,R.G., Ye,H., Parkinson,J. and Guilford,W.J.<br>Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase<br>Bioorg Med Chem Lett (2008) 18, 3891-3894. PubMed  Europe PubMed DOI  I
    63. 2007
  63. Haeggstrom,J.Z., Tholander,F. and Wetterholm,A.<br>Structure and catalytic mechanisms of leukotriene A4 hydrolase<br>Prostaglandins Other Lipid Mediat (2007) 83, 198-202. PubMed  Europe PubMed DOI  V
  64. Liang,A.M., Claret,E., Ouled-Diaf,J., Jean,A., Vogel,D., Light,D.R., Jones,S.W., Guilford,W.J., Parkinson,J.F. and Snider,R.M.<br>Development of a Homogeneous Time-Resolved Fluorescence Leukotriene B4 Assay for Determining the Activity of Leukotriene A4 Hydrolase<br>J Biomol Screen (2007) 12, 536-545. PubMed  Europe PubMed DOI  A
  65. Rao,N.L., Dunford,P.J., Xue,X., Jiang,X., Lundeen,K.A., Coles,F., Riley,J.P., Williams,K.N., Grice,C.A., Edwards,J.P., Karlsson,L. and Fourie,A.M.<br>Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton<br>J Pharmacol Exp Ther (2007) 321, 1154-1160. PubMed  Europe PubMed DOI  I
  66. Tholander,F. and Haeggstrom,J.Z.<br>Assay for rapid analysis of the tri-peptidase activity of LTA4 hydrolase<br>Proteins (2007) 67, 1113-1118. PubMed  Europe PubMed DOI  A
    67. 2006
  67. [YEAR:1-6-2006]Arguello,M., Paz,S., Hernandez,E., Corriveau-Bourque,C., Fawaz,L.M., Hiscott,J. and Lin,R.<br>Leukotriene A4 hydrolase expression in PEL cells is regulated at the transcriptional level and leads to increased leukotriene B4 production<br>J Immunol (1-6-2006) 176, 7051-7061. PubMed  Europe PubMed
  68. [YEAR:10-11-2006]Helgadottir,A., Manolescu,A., Helgason,A., Thorleifsson,G., Thorsteinsdottir,U., Gudbjartsson,D.F., Gretarsdottir,S., Magnusson,K.P., Gudmundsson,G., Hicks,A., Jonsson,T., Grant,S.F., Sainz,J., O'Brien,S.J., Sveinbjornsdottir,S., Valdimarsson,E.M., Matthiasson,S.E., Levey,A.I., Abramson,J.L., Reilly,M.P., Vaccarino,V., Wolfe,M.L., Gudnason,V., Quyyumi,A.A., Topol,E.J., Rader,D.J., Thorgeirsson,G., Gulcher,J.R., Hakonarson,H., Kong,A. and Stefansson,K.<br>A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction<br>Nat Genet (10-11-2006) 38, 68-74. PubMed  Europe PubMed DOI  M
    69. 2005
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