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Literature for peptidase M01.004: leukotriene A4 hydrolase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, M Mutation, P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Thoma,G., Miltz,W., Srinivas,H., Penno,C.A., Kiffe,M., Gajewska,M., Klein,K., Evans,A., Beerli,C. and Rohn,T.A.
    Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor
    J Med Chem67, 5093-5108. PubMed  Europe PubMed DOI
  2. Xu,X., Li,J.D., Green,T.J., Wilson,L., Genschmer,K., Russell,D., Blalock,J.E. and Gaggar,A.
    Neutrophil elastase-dependent cleavage of LTA4H alters its aminopeptidase activity in cystic fibrosis
    Eur Respir J63, PubMed  Europe PubMed DOI
    3. 2023
  3. Adams,J.M., Rege,S.V., Liu,A.T., Vu,N.V., Raina,S., Kirsher,D.Y., Nguyen,A.L., Harish,R., Szoke,B., Leone,D.P., Czirr,E., Braithwaite,S. and Kerrisk Campbell,M.
    Leukotriene A4 hydrolase inhibition improves age-related cognitive decline via modulation of synaptic function
    Sci Adv9, eadf8764-eadf8764. PubMed  Europe PubMed DOI
  4. Cai,Y., Mu,X., Li,G. and Xu,D.
    Quantum Mechanical/Molecular Mechanical Elucidation of the Catalytic Mechanism of Leukotriene A4 Hydrolase as an Epoxidase
    J Phys Chem B127, 10338-10350. PubMed  Europe PubMed DOI
  5. Kumar,S.S., Solomon,R., Gautam,P., Inbaraj,L.R., Sivadasan,A., Michael,J.S., Karthik,R., Varghese,G.M., Christudass,C.S., Samuel,P. and Manesh,A.
    Leukotriene A4 hydrolase (LTA4H rs17525495) gene polymorphisms and paradoxical reactions in extrapulmonary tuberculosis
    Sci Rep13, 3746-3746. PubMed  Europe PubMed DOI
    6. 2022
  6. Canyelles-Nino,M., Gonzalez-Lafont,A. and Lluch,J.M.
    Theoretical Characterization of the Step-by-Step Mechanism of Conversion of Leukotriene A4 to Leukotriene B4 Catalysed by the Enzyme Leukotriene A4 Hydrolase
    Int J Mol Sci23, PubMed  Europe PubMed DOI
  7. Fang,M., Tang,X., Zhang,J., Liao,Z., Wang,G., Cheng,R., Zhang,Z., Zhao,H., Wang,J., Tan,Z., Kamau,P.M., Lu,Q., Liu,Q., Deng,G. and Lai,R.
    An inhibitor of leukotriene-A4 hydrolase from bat salivary glands facilitates virus infection
    Proc Natl Acad Sci U S A119, e2110647119-e2110647119. PubMed  Europe PubMed DOI
    8. 2021
  8. Rohn,T.A., Numao,S., Otto,H., Loesche,C. and Thoma,G.
    Drug discovery strategies for novel leukotriene A4 hydrolase inhibitors
    Expert Opin Drug Discov1-13. PubMed  Europe PubMed DOI  V
  9. Whitworth,L., Coxon,J., van Laarhoven,A., Thuong,N.T.T., Dian,S., Alisjahbana,B., Ganiem,A.R., van Crevel,R., Thwaites,G.E., Troll,M., Edelstein,P.H., Sewell,R. and Ramakrishnan,L.
    A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis
    elife10, PubMed  Europe PubMed DOI
    10. 2020
  10. Uzawa,H., Kohno,D., Koga,T., Sasaki,T., Fukunaka,A., Okuno,T., Jo-Watanabe,A., Kazuno,S., Miyatsuka,T., Kitamura,T., Fujitani,Y., Watada,H., Saeki,K. and Yokomizo,T.
    Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis
    FASEB J34, 13949-13958. PubMed  Europe PubMed DOI  K
    11. 2019
  11. Lee,K.H., Petruncio,G., Shim,A., Burdick,M., Zhang,Z., Shim,Y.M., Noble,S.M. and Paige,M.
    Effect of modifier structure on the activation of leukotriene A4 hydrolase aminopeptidase activity
    J Med Chem62, 10605-10616. PubMed  Europe PubMed DOI  S
    12. 2018
  12. Vo,T.T.L., Jang,W.J. and Jeong,C.H.
    Leukotriene A4 hydrolase: an emerging target of natural products for cancer chemoprevention and chemotherapy
    Ann N Y Acad Sci1431, 3-13. PubMed  Europe PubMed DOI
    13. 2017
  13. Low,C.M., Akthar,S., Patel,D.F., Loser,S., Wong,C.T., Jackson,P.L., Blalock,J.E., Hare,S.A., Lloyd,C.M. and Snelgrove,R.J.
    The development of novel LTA4H modulators to selectively target LTB4 generation
    Sci Rep7, 44449-44449. PubMed  Europe PubMed DOI
  14. Numao,S., Hasler,F., Laguerre,C., Srinivas,H., Wack,N., Jager,P., Schmid,A., Osmont,A., Rothlisberger,P., Houguenade,J., Bergsdorf,C., Dawson,J., Carte,N., Hofmann,A., Markert,C., Hardaker,L., Billich,A., Wolf,R.M., Penno,C.A., Bollbuck,B., Miltz,W. and Rohn,T.A.
    Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors
    Sci Rep7, 13591-13591. PubMed  Europe PubMed DOI  I
  15. Stsiapanava,A., Samuelsson,B. and Haeggstrom,J.Z.
    Capturing LTA4 hydrolase in action: insights to the chemistry and dynamics of chemotactic LTB4 synthesis
    Proc Natl Acad Sci U S A114, 9689-9694. PubMed  Europe PubMed DOI
  16. Torres,M.J., Fierro,A., Pessoa-Mahana,C.D., Romero-Parra,J., Cabrera,G. and Faundez,M.
    Effect of alpha lipoic acid on leukotriene A4 hydrolase
    Eur J Pharmacol799, 41-47. PubMed  Europe PubMed DOI  I
  17. Zhang,F., Wu,D., Wang,G.-L., Hou,S., Ou-Yang,P., Huang,J. and Xu,X.-Y.
    Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A4 hydrolase aminopeptidase inhibitors
    Chin Chem Lett28, 1044-1048. DOI  I
    18. 2016
  18. Wittmann,S.K., Kalinowsky,L., Kramer,J.S., Bloecher,R., Knapp,S., Steinhilber,D., Pogoryelov,D., Proschak,E. and Heering,J.
    Thermodynamic properties of leukotriene A4 hydrolase inhibitors
    Bioorg Med Chem24, 5243-5248. PubMed  Europe PubMed DOI  I
  19. Xiao,Q., Dong,N., Yao,X., Wu,D., Lu,Y., Mao,F., Zhu,J., Li,J., Huang,J., Chen,A., Huang,L., Wang,X., Yang,G., He,G., Xu,Y. and Lu,W.
    Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H
    Sci Rep6, 25298-25298. PubMed  Europe PubMed DOI  I
    20. 2015
  20. Paz,P.B., Vega-Hissi,E.G., Andrada,M.F., Estrada,M.R. and Garro Martinez,J.C.
    Quantitative structure activity relationship and binding investigation of N-alkyl glycine amides as inhibitors of leukotriene A4 hydrolase
    Med Chem Res24, 496-504. DOI  I
    21. 2014
  21. Barchuk,W., Lambert,J., Fuhr,R., Jiang,J.Z., Bertelsen,K., Fourie,A., Liu,X., Silkoff,P.E., Barnathan,E.S. and Thurmond,R.
    Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma
    Pulm Pharmacol Ther29, 15-23. PubMed  Europe PubMed DOI  I
  22. Byzia,A., Haeggstrom,J.Z., Salvesen,G.S. and Drag,M.
    A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids
    Amino Acids46, 1313-1320. PubMed  Europe PubMed DOI  P
  23. Hitzerd,S.M., Verbrugge,S.E., Ossenkoppele,G., Jansen,G. and Peters,G.J.
    Positioning of aminopeptidase inhibitors in next generation cancer therapy
    Amino Acids46, 793-808. PubMed  Europe PubMed DOI  I
  24. Stsiapanava,A., Olsson,U., Wan,M., Kleinschmidt,T., Rutishauser,D., Zubarev,R.A., Samuelsson,B., Rinaldo-Matthis,A. and Haeggstrom,J.Z.
    Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor
    Proc Natl Acad Sci U S A111, 4227-4232. PubMed  Europe PubMed DOI  S  I
  25. Stsiapanava,A., Tholander,F., Kumar,R.B., Qureshi,A.A., Niegowski,D., Hasan,M., Thunnissen,M., Haeggstrom,J.Z. and Rinaldo-Matthis,A.
    Product formation controlled by substrate dynamics in leukotriene A4 hydrolase
    Biochim Biophys Acta1844, 439-446. PubMed  Europe PubMed DOI  S
    26. 2013
  26. Caliskan,B. and Banoglu,E.
    Overview of recent drug discovery approaches for new generation leukotriene A4 hydrolase inhibitors
    Expert Opin Drug Discov8, 49-63. PubMed  Europe PubMed DOI  V  I
  27. Eccles,W., Blevitt,J.M., Booker,J.N., Chrovian,C.C., Crawford,S., de Leon,A.R., Deng,X., Fourie,A.M., Grice,C.A., Herman,K., Karlsson,L., Kearney,A.M., Lee-Dutra,A., Liang,J., Luna,R., Pippel,D., Rao,N., Riley,J.P., Santillan,A., Savall,B., Tanis,V.M., Xue,X. and Young,A.L.
    Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase
    Bioorg Med Chem Lett23, 811-815. PubMed  Europe PubMed DOI  I
  28. Meng,H., Liu,Y., Zhai,Y. and Lai,L.
    Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase
    Eur J Med Chem59, 160-167. PubMed  Europe PubMed DOI  I
  29. Poras,H., Duquesnoy,S., Fournie-Zaluski,M.C., Ratinaud-Giraud,C., Roques,B.P. and Ouimet,T.
    A sensitive fluorigenic substrate for selective in vitro and in vivo assay of leukotriene A4 hydrolase activity
    Anal Biochem441, 152-161. PubMed  Europe PubMed DOI  A
  30. Thangapandian,S., John,S., Son,M., Arulalapperumal,V. and Lee,K.W.
    Development of predictive quantitative structure-activity relationship model and its application in the discovery of human leukotriene A4 hydrolase inhibitors
    Future Med Chem5, 27-40. PubMed  Europe PubMed DOI  I
  31. Zhao,J., Goldberg,J. and Vaccarino,V.
    Leukotriene A4 hydrolase haplotype, diet and atherosclerosis: a twin study
    Atherosclerosis226, 238-244. PubMed  Europe PubMed DOI  M
    32. 2012
  32. Haeggstrom,J.Z.
    Leukotriene A4 hydrolase
    [ISSN:978-0-12-407744-7]3, 468-472. DOI
  33. Tanis,V.M., Bacani,G.M., Blevitt,J.M., Chrovian,C.C., Crawford,S., De Leon,A., Fourie,A.M., Gomez,L., Grice,C.A., Herman,K., Kearney,A.M., Landry-Bayle,A.M., Lee-Dutra,A., Nelson,J., Riley,J.P., Santillan,A., Jr., Wiener,J.J., Xue,X. and Young,A.L.
    Azabenzthiazole inhibitors of leukotriene A4 hydrolase
    Bioorg Med Chem Lett22, 7504-7511. PubMed  Europe PubMed DOI  I
    34. 2011
  34. De Oliveira,E.O., Wang,K., Kong,H.S., Kim,S., Miessau,M., Snelgrove,R.J., Shim,Y.M. and Paige,M.
    Effect of the leukotriene A4 hydrolase aminopeptidase augmentor 4-methoxydiphenylmethane in a pre-clinical model of pulmonary emphysema
    Bioorg Med Chem Lett21, 6746-6750. PubMed  Europe PubMed DOI
  35. Sarker,M.A., Matsuda,S., Mizutani,O., Rao,S., Migita,K., Goto-Yamamoto,N., Iefuji,H. and Nishimura,T.
    Purification and characterization of porcine skeletal muscle aminopeptidase T, a novel metallopeptidase homologous to leukotriene A4 hydrolase
    Biosci Biotechnol Biochem75, 1154-1159. PubMed  Europe PubMed DOI
  36. Snelgrove,R.J.
    Leukotriene A4 hydrolase: an anti-inflammatory role for a proinflammatory enzyme
    Thorax66, 550-551. PubMed  Europe PubMed DOI
  37. Thangapandian,S., John,S., Sakkiah,S. and Lee,K.W.
    Pharmacophore-based virtual screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors
    Eur J Med Chem46, 1593-1603. PubMed  Europe PubMed DOI  I
  38. Thangapandian,S., John,S., Sakkiah,S. and Lee,K.W.
    Molecular docking and pharmacophore filtering in the discovery of dual-inhibitors for human leukotriene A4 hydrolase and leukotriene C4 synthase
    J Chem Inf Model51, 33-44. PubMed  Europe PubMed DOI  I
    39. 2010
  39. Jiang,X., Zhou,L., Wu,Y., Wei,D., Sun,C., Jia,J., Liu,Y. and Lai,L.
    Modulating the substrate specificity of LTA4H aminopeptidase by using chemical compounds and small-molecule-guided mutagenesis
    Chembiochem11, 1120-1128. PubMed  Europe PubMed DOI  P
  40. Oi,N., Jeong,C.H., Nadas,J., Cho,Y.Y., Pugliese,A., Bode,A.M. and Dong,Z.
    Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A4 hydrolase
    Cancer Res70, 9755-9764. PubMed  Europe PubMed DOI  I
  41. Rao,N.L., Riley,J.P., Banie,H., Xue,X., Sun,B., Crawford,S., Lundeen,K.A., Yu,F., Karlsson,L., Fourie,A.M. and Dunford,P.J.
    Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness
    Am J Respir Crit Care Med181, 899-907. PubMed  Europe PubMed DOI  I
  42. Rinaldo-Matthis,A. and Haeggstrom,J.Z.
    Structures and mechanisms of enzymes in the leukotriene cascade
    Biochimie92, 676-681. PubMed  Europe PubMed DOI
  43. Sandanayaka,V., Mamat,B., Bhagat,N., Bedell,L., Halldorsdottir,G., Sigthorsdottir,H., Andresson,T., Kiselyov,A., Gurney,M. and Singh,J.
    Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds
    Bioorg Med Chem Lett20, 2851-2854. PubMed  Europe PubMed DOI  I
  44. Sandanayaka,V., Mamat,B., Mishra,R.K., Winger,J., Krohn,M., Zhou,L.M., Keyvan,M., Enache,L., Sullins,D., Onua,E., Zhang,J., Halldorsdottir,G., Sigthorsdottir,H., Thorlaksdottir,A., Sigthorsson,G., Thorsteinnsdottir,M., Davies,D.R., Stewart,L.J., Zembower,D.E., Andresson,T., Kiselyov,A.S., Singh,J. and Gurney,M.E.
    Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis
    J Med Chem53, 573-585. PubMed  Europe PubMed DOI  I
  45. Snelgrove,R.J., Jackson,P.L., Hardison,M.T., Noerager,B.D., Kinloch,A., Gaggar,A., Shastry,S., Rowe,S.M., Shim,Y.M., Hussell,T. and Blalock,J.E.
    A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation
    Science330, 90-94. PubMed  Europe PubMed DOI
  46. Sonawane,L.V. and Bari,S.B.
    QSAR, docking studies and pharmacophore identification of phenylmethyl phenoxy propyl amino propanoic acid derivatives as leukotriene A4 hydrolase inhibitors
    Yao Xue Xue Bao45, 615-623. PubMed  Europe PubMed  I
  47. Tholander,F., Roques,B.P., Fournie-Zaluski,M.C., Thunnissen,M.M. and Haeggstrom,J.Z.
    Crystal structure of leukotriene A4 hydrolase in complex with kelatorphan, implications for design of zinc metallopeptidase inhibitors
    FEBS Lett584, 3446-3451. PubMed  Europe PubMed DOI  S  I
    48. 2009
  48. Davies,D.R., Mamat,B., Magnusson,O.T., Christensen,J., Haraldsson,M.H., Mishra,R., Pease,B., Hansen,E., Singh,J., Zembower,D., Kim,H., Kiselyov,A.S., Burgin,A.B., Gurney,M.E. and Stewart,L.J.
    Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography
    J Med Chem52, 4694-4715. PubMed  Europe PubMed DOI  I
  49. Enomoto,H., Morikawa,Y., Miyake,Y., Tsuji,F., Mizuchi,M., Suhara,H., Fujimura,K., Horiuchi,M. and Ban,M.
    Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors
    Bioorg Med Chem Lett19, 442-446. PubMed  Europe PubMed DOI  I
  50. Fourie,A.M.
    Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase
    Curr Opin Investig Drugs10, 1173-1182. PubMed  Europe PubMed  V  I
  51. Jeong,C.H., Bode,A.M., Pugliese,A., Cho,Y.Y., Kim,H.G., Shim,J.H., Jeon,Y.J., Li,H., Jiang,H. and Dong,Z.
    [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase
    Cancer Res69, 5584-5591. PubMed  Europe PubMed DOI  I
  52. Zhao,J., Quyyumi,A.A., Patel,R., Zafari,A.M., Veledar,E., Onufrak,S., Shallenberger,L.H., Jones,L. and Vaccarino,V.
    Sex-specific association of depression and a haplotype in leukotriene A4 hydrolase gene
    Psychosom Med71, 691-696. PubMed  Europe PubMed DOI  M
    53. 2008
  53. Enomoto,H., Morikawa,Y., Miyake,Y., Tsuji,F., Mizuchi,M., Suhara,H., Fujimura,K., Horiuchi,M. and Ban,M.
    Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors
    Bioorg Med Chem Lett18, 4529-4532. PubMed  Europe PubMed DOI  I
  54. Grice,C.A. and Gomez,L.
    Current status of leukotriene A4 hydrolase inhibitors
    Expert Opin Ther Pat18, 1333-1350. DOI  I
  55. Grice,C.A., Tays,K.L., Savall,B.M., Wei,J., Butler,C.R., Axe,F.U., Bembenek,S.D., Fourie,A.M., Dunford,P.J., Lundeen,K., Coles,F., Xue,X., Riley,J.P., Williams,K.N., Karlsson,L. and Edwards,J.P.
    Identification of a potent, selective, and orally active leukotriene A4 hydrolase inhibitor with anti-inflammatory activity
    J Med Chem51, 4150-4169. PubMed  Europe PubMed DOI  I
  56. Jiang,X., Zhou,L., Wei,D., Meng,H., Liu,Y. and Lai,L.
    Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives
    Bioorg Med Chem Lett18, 6549-6552. PubMed  Europe PubMed DOI  I
  57. Khim,S.K., Bauman,J., Evans,J., Freeman,B., King,B., Kirkland,T., Kochanny,M., Lentz,D., Liang,A., Mendoza,L., Phillips,G., Tseng,J.L., Wei,R.G., Ye,H., Yu,L., Parkinson,J. and Guilford,W.J.
    Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors
    Bioorg Med Chem Lett18, 3895-3898. PubMed  Europe PubMed DOI  I
  58. Kirkland,T.A., Adler,M., Bauman,J.G., Chen,M., Haeggstrom,J.Z., King,B., Kochanny,M.J., Liang,A.M., Mendoza,L., Phillips,G.B., Thunnissen,M., Trinh,L., Whitlow,M., Ye,B., Ye,H., Parkinson,J. and Guilford,W.J.
    Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase
    Bioorg Med Chem16, 4963-4983. PubMed  Europe PubMed DOI  I
  59. Tholander,F., Muroya,A., Roques,B.P., Fournie-Zaluski,M.C., Thunnissen,M.M. and Haeggstrom,J.Z.
    Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design
    Chem Biol15, 920-929. PubMed  Europe PubMed DOI
  60. Whittle,B.J., Varga,C., Berko,A., Horvath,K., Posa,A., Riley,J.P., Lundeen,K.A., Fourie,A.M. and Dunford,P.J.
    Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase
    Br J Pharmacol153, 983-991. PubMed  Europe PubMed DOI  I
  61. Ye,B., Bauman,J., Chen,M., Davey,D., Khim,S.K., King,B., Kirkland,T., Kochanny,M., Liang,A., Lentz,D., May,K., Mendoza,L., Phillips,G., Selchau,V., Schlyer,S., Tseng,J.L., Wei,R.G., Ye,H., Parkinson,J. and Guilford,W.J.
    Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase
    Bioorg Med Chem Lett18, 3891-3894. PubMed  Europe PubMed DOI  I
    62. 2007
  62. Haeggstrom,J.Z., Tholander,F. and Wetterholm,A.
    Structure and catalytic mechanisms of leukotriene A4 hydrolase
    Prostaglandins Other Lipid Mediat83, 198-202. PubMed  Europe PubMed DOI  V
  63. Liang,A.M., Claret,E., Ouled-Diaf,J., Jean,A., Vogel,D., Light,D.R., Jones,S.W., Guilford,W.J., Parkinson,J.F. and Snider,R.M.
    Development of a Homogeneous Time-Resolved Fluorescence Leukotriene B4 Assay for Determining the Activity of Leukotriene A4 Hydrolase
    J Biomol Screen12, 536-545. PubMed  Europe PubMed DOI  A
  64. Rao,N.L., Dunford,P.J., Xue,X., Jiang,X., Lundeen,K.A., Coles,F., Riley,J.P., Williams,K.N., Grice,C.A., Edwards,J.P., Karlsson,L. and Fourie,A.M.
    Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton
    J Pharmacol Exp Ther321, 1154-1160. PubMed  Europe PubMed DOI  I
  65. Tholander,F. and Haeggstrom,J.Z.
    Assay for rapid analysis of the tri-peptidase activity of LTA4 hydrolase
    Proteins67, 1113-1118. PubMed  Europe PubMed DOI  A
    66. 2006
  66. [YEAR:1-6-2006]Arguello,M., Paz,S., Hernandez,E., Corriveau-Bourque,C., Fawaz,L.M., Hiscott,J. and Lin,R.
    Leukotriene A4 hydrolase expression in PEL cells is regulated at the transcriptional level and leads to increased leukotriene B4 production
    J Immunol176, 7051-7061. PubMed  Europe PubMed
  67. [YEAR:10-11-2006]Helgadottir,A., Manolescu,A., Helgason,A., Thorleifsson,G., Thorsteinsdottir,U., Gudbjartsson,D.F., Gretarsdottir,S., Magnusson,K.P., Gudmundsson,G., Hicks,A., Jonsson,T., Grant,S.F., Sainz,J., O'Brien,S.J., Sveinbjornsdottir,S., Valdimarsson,E.M., Matthiasson,S.E., Levey,A.I., Abramson,J.L., Reilly,M.P., Vaccarino,V., Wolfe,M.L., Gudnason,V., Quyyumi,A.A., Topol,E.J., Rader,D.J., Thorgeirsson,G., Gulcher,J.R., Hakonarson,H., Kong,A. and Stefansson,K.
    A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
    Nat Genet38, 68-74. PubMed  Europe PubMed DOI  M
    68. 2005
  68. [YEAR:1-4-2005]Brock,T.G., Lee,Y.J., Maydanski,E., Marburger,T.L., Luo,M., Paine,R., III and Peters-Golden,M.
    Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung
    Am J Physiol Lung Cell Mol Physiol289, L224-L232. PubMed  Europe PubMed DOI
    69. 2004
  69. Chen,X., Wang,S., Wu,N. and Yang,C.S.
    Leukotriene A4 hydrolase as a target for cancer prevention and therapy
    Curr Cancer Drug Targets4, 267-283. PubMed  Europe PubMed DOI  I
  70. [YEAR:31-8-2004]Haeggstrom,J.Z.
    Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis
    J Biol Chem279, 50639-50642. PubMed  Europe PubMed DOI
  71. Haeggstrom,J.Z.
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