Substrates for peptidase C03.014: human enterovirus 71 3C peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
cleavage stimulation factor subunit 2	P33240	2-577	peptide-Gln251+Gly-peptide	N	MU	Ala	Ser	Met	Gln	Gly	Gly	Val	Pro	Weng et al., 2009
Dabcyl-KTSAVLQSGFRKME-Edans			Dabcyl-KTSAVLQ+SGFRKME-Edans	S		Ala	Val	Leu	Gln	Ser	Gly	Phe	Arg	Kuo et al., 2008
polyprotein	Q9WQJ0	318-329	Arg-Gln-Ala-Val-Thr-Gln+Gly-Phe-Pro-Thr-Glu-Leu	P	CS	Ala	Val	Thr	Gln	Gly	Phe	Pro	Thr	Kuo et al., 2008
polyprotein	Q9WQJ0	560-571	Gln-Thr-Gly-Thr-Ile-Gln+Gly-Asp-Arg-Val-Ala-Asp	P	CS	Gly	Thr	Ile	Gln	Gly	Asp	Arg	Val	Kuo et al., 2008
polyprotein	Q9WQJ0	1007-1018	Asp-Glu-Ala-Met-Glu-Gln+Gly-Val-Ser-Asp-Tyr-Ile	P	CS	Ala	Met	Glu	Gln	Gly	Val	Ser	Asp	Kuo et al., 2008
polyprotein	Q9WQJ0	1543-1554	Arg-Thr-Ala-Thr-Val-Gln+Gly-Pro-Ser-Leu-Asp-Phe	P	CS	Ala	Thr	Val	Gln	Gly	Pro	Ser	Leu	Kuo et al., 2008
polyprotein	Q9WQJ0	1726-1737	Tyr-Phe-Cys-Ser-Glu-Gln+Gly-Glu-Ile-Gln-Trp-Met	P	CS	Cys	Ser	Glu	Gln	Gly	Glu	Ile	Gln	Kuo et al., 2008
polyprotein	Q9WQJ0	1435-1446	Ile-Glu-Ala-Leu-Phe-Gln+Gly-Pro-Pro-Lys-Phe-Arg	P	CS	Ala	Leu	Phe	Gln	Gly	Pro	Pro	Lys	Kuo et al., 2008
replicase polyprotein 1a	P0C6U8	3235-3246	Thr-Ser-Ala-Val-Leu-Gln+Ser-Gly-Phe-Arg-Lys-Met	N		Ala	Val	Leu	Gln	Ser	Gly	Phe	Arg	Kuo et al., 2008
TAR DNA-binding protein 43	Q13148	1-414	peptide-Gln331+Ser-peptide	P	NT	Ala	Ala	Leu	Gln	Ser	Ser	Trp	Gly	Wo et al., 2020