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Literature for peptidase C03.014: human enterovirus 71 3C peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, P Specificity, K Knockout, E Expression, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Hu,S., Zhong,Q., Xie,X., Zhang,S., Wang,J., Liu,H. and Dai,W.
    Research progress on critical viral protease inhibitors for coronaviruses and enteroviruses
    Bioorg Med Chem Lett (2025) 122, 130168-130168. PubMed  Europe PubMed DOI
  2. Ye,J., Zhang,R., Liu,X. and Chen,Y.
    Production of a genetically encoded biosensor for evaluating enterovirus 71 3C protease inhibitors
    Prep Biochem Biotechnol (2025) , 1-6. PubMed  Europe PubMed DOI  I
    3. 2024
  3. Jassey,A., Paudel,B., Wagner,M.A., Pollack,N., Cheng,I.T., Godoy-Ruiz,R., Weber,D.J. and Jackson,W.T.
    Mitophagosomes induced during EV-D68 infection promote viral nonlytic release
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  4. Li,H., Song,J., Deng,Z., Yao,Y., Qiao,W. and Tan,J.
    Cleavage of Stau2 by 3C protease promotes EV-A71 replication
    Virol J (2024) 21, 216-216. PubMed  Europe PubMed DOI  PMC  EPMC  K
  5. Zhang,D., Xie,Y., Cao,J., Huang,L. and Fan,W.
    Enteroviral 3C protease cleaves N4BP1 to impair the host inflammatory response
    J Virol (2024) , e0175824-e0175824. PubMed  Europe PubMed DOI
    6. 2022
  6. Primavera,V., Simmons,J., Clark,B.A., Neilan,J.G. and Puckette,M.
    Effect of Foot-and-Mouth Disease Virus 2B Viroporin on Expression and Extraction of Mammalian Cell Culture Produced Foot-and-Mouth Disease Virus-like Particles
    Vaccines (Basel) (2022) 10 PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2021
  7. Li,Z., Wu,Y., Li,H., Li,W., Tan,J. and Qiao,W.
    3C protease of enterovirus 71 cleaves promyelocytic leukemia protein and impairs PML-NBs production
    Virol J (2021) 18, 255-255. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Wo,X., Yuan,Y., Xu,Y., Chen,Y., Wang,Y., Zhao,S., Lin,L., Zhong,X., Wang,Y., Zhong,Z. and Zhao,W.
    TAR DNA-Binding Protein 43 is Cleaved by the Protease 3C of Enterovirus A71
    Virol Sin (2021) 36, 95-103. PubMed  Europe PubMed DOI
    9. 2020
  9. Wen,W., Qi,Z. and Wang,J.
    The Function and Mechanism of Enterovirus 71 (EV71) 3C Protease
    Curr Microbiol (2020) 77, 1968-1975. PubMed  Europe PubMed DOI
    10. 2019
  10. Cao,J., Liu,H., Qu,M., Hou,A., Zhou,Y., Sun,B., Cai,L., Gao,F., Su,W. and Jiang,C.
    Determination of the cleavage site of enterovirus 71 VP0 and the effect of this cleavage on viral infectivity and assembly
    Microb Pathog (2019) 134, 103568-103568. PubMed  Europe PubMed DOI
  11. Li,M.L., Lin,J.Y., Chen,B.S., Weng,K.F., Shih,S.R., Calderon,J.D., Tolbert,B.S. and Brewer,G.
    EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation
    PLoS ONE (2019) 14, e0221048-e0221048. PubMed  Europe PubMed DOI
  12. Ma,Y., Li,L., He,S., Shang,C., Sun,Y., Liu,N., Meek,T.D., Wang,Y. and Shang,L.
    Application of dually activated Michael acceptor to the rational design of reversible covalent inhibitor for enterovirus 71 3C protease
    J Med Chem (2019) 62, 6146-6162. PubMed  Europe PubMed DOI  I
    13. 2018
  13. Fu,S., Nie,Q., Ma,Y., Song,P., Ren,X., Luo,C., Shang,L. and Yin,Z.
    Target-guided screening of fragments (TGSOF) in the discovery of inhibitors against EV-A71 3C protease
    Chem Commun (Camb) (2018) 54, 2890-2893. PubMed  Europe PubMed DOI  I
  14. Ma,Y., Shang,C., Yang,P., Li,L., Zhai,Y., Yin,Z., Wang,B. and Shang,L.
    4-Iminooxazolidin-2-one as a bioisostere of the cyanohydrin moiety: inhibitors of enterovirus 71 3C protease
    J Med Chem (2018) 61, 10333-10339. PubMed  Europe PubMed DOI  I
  15. Nie,Q., Xu,X., Zhang,Q., Ma,Y., Yin,Z. and Shang,L.
    3D-Quantitative structure-activity relationship study for the design of novel enterovirus A71 3C protease inhibitors
    Chem Biol Drug Des (2018) 92, 1750-1762. PubMed  Europe PubMed DOI  I
  16. Rasti,M., Khanbabaei,H. and Teimoori,A.
    An update on enterovirus 71 infection and interferon type I response
    Rev Med Virol (2018) , e2016-e2016. PubMed  Europe PubMed DOI
  17. Xie,L., Lu,B., Zheng,Z., Miao,Y., Liu,Y., Zhang,Y., Zheng,C., Ke,X., Hu,Q. and Wang,H.
    The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP)
    J Gen Virol (2018) 99, 73-85. PubMed  Europe PubMed DOI
  18. Yao,C., Xi,C., Hu,K., Gao,W., Cai,X., Qin,J., Lv,S., Du,C. and Wei,Y.
    Inhibition of enterovirus 71 replication and viral 3C protease by quercetin
    Virol J (2018) 15, 116-116. PubMed  Europe PubMed DOI  PMC  EPMC  I
    19. 2017
  19. Lei,X., Zhang,Z., Xiao,X., Qi,J., He,B. and Wang,J.
    Enterovirus 71 inhibits pyroptosis through cleavage of GSDMD
    J Virol (2017) 91, e01069-17-e01069-17. PubMed  Europe PubMed DOI
  20. Li,B., Yue,Y., Zhang,Y., Yuan,Z., Li,P., Song,N., Lin,W., Liu,Y., Gu,L. and Meng,H.
    A novel enterovirus 71 (EV71) virulence determinant: the 69th residue of 3C protease modulates pathogenicity
    Front Cell Infect Microbiol (2017) 7, 26-26. PubMed  Europe PubMed DOI  PMC  EPMC  S
  21. Li,J., Yao,Y., Chen,Y., Xu,X., Lin,Y., Yang,Z., Qiao,W. and Tan,J.
    Enterovirus 71 3C promotes apoptosis through cleavage of PinX1, a telomere binding protein
    J Virol (2017) 91, e02016-16-e02016-16. PubMed  Europe PubMed DOI
  22. Rui,Y., Su,J., Wang,H., Chang,J., Wang,S., Zheng,W., Cai,Y., Wei,W., Gordy,J.T., Markham,R., Kong,W., Zhang,W. and Yu,X.F.
    Disruption of MDA5 mediated innate immune responses by the 3C proteins of Coxsackievirus A16, Coxsackievirus A6, and Enterovirus D68
    J Virol (2017) DOI
  23. Wang,Y., Cao,L., Zhai,Y., Ma,J., Nie,Q., Li,T., Yin,Z., Sun,Y. and Shang,L.
    Inhibition of enterovirus 71 replication by an alpha-hydroxy-nitrile derivative NK-1.9k
    Antiviral Res (2017) 141, 91-100. PubMed  Europe PubMed DOI  I
  24. Zhang,Y., Ke,X., Zheng,C., Liu,Y., Xie,L., Zheng,Z. and Wang,H.
    Development of a luciferase-based biosensor to assess enterovirus 71 3C protease activity in living cells
    Sci Rep (2017) 7, 10385-10385. PubMed  Europe PubMed DOI  PMC  EPMC  A  L
    25. 2016
  25. Ang,M.J., Lau,Q.Y., Ng,F.M., Then,S.W., Poulsen,A., Cheong,Y.K., Ngoh,Z.X., Tan,Y.W., Peng,J., Keller,T.H., Hill,J., Chu,J.J. and Brian Chia,C.S.
    Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study
    J Enzyme Inhib Med Chem (2016) 31, 332-339. PubMed  Europe PubMed DOI  I
  26. Cao,Z., Ding,Y., Ke,Z., Cao,L., Li,N., Ding,G., Wang,Z. and Xiao,W.
    Luteoloside acts as 3C protease inhibitor of enterovirus 71 in vitro
    PLoS ONE (2016) 11, e0148693-e0148693. PubMed  Europe PubMed DOI  I
  27. Jetsadawisut,W., Nutho,B., Meeprasert,A., Rungrotmongkol,T., Kungwan,N., Wolschann,P. and Hannongbua,S.
    Susceptibility of inhibitors against 3C protease of coxsackievirus A16 and enterovirus A71 causing hand, foot and mouth disease: a molecular dynamics study
    Biophys Chem (2016) 219, 9-16. PubMed  Europe PubMed DOI  I
  28. Li,P., Yue,Y., Song,N., Li,B., Meng,H., Yang,G., Li,Z., An,L. and Qin,L.
    Genome analysis of enterovirus 71 strains differing in mouse pathogenicity
    Virus Genes (2016) 52, 161-171. PubMed  Europe PubMed DOI  M
  29. Ma,G.H., Ye,Y., Zhang,D., Xu,X., Si,P., Peng,J.L., Xiao,Y.L., Cao,R.Y., Yin,Y.L., Chen,J., Zhao,L.X., Zhou,Y., Zhong,W., Liu,H., Luo,X.M., Chen,L.L. and Shen,X.
    Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening
    Eur J Med Chem (2016) 124, 981-991. PubMed  Europe PubMed DOI  I
  30. Tan,Y.W., Ang,M.J., Lau,Q.Y., Poulsen,A., Ng,F.M., Then,S.W., Peng,J., Hill,J., Hong,W.J., Chia,C.S. and Chu,J.J.
    Antiviral activities of peptide-based covalent inhibitors of the enterovirus 71 3C protease
    Sci Rep (2016) 6, 33663-33663. PubMed  Europe PubMed DOI  PMC  EPMC  I
  31. Wu,C., Zhang,L., Li,P., Cai,Q., Peng,X., Yin,K., Chen,X., Ren,H., Zhong,S., Weng,Y., Guan,Y., Chen,S., Wu,J., Li,J. and Lin,T.
    Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71
    Biochim Biophys Acta (2016) 1860, 1299-1307. PubMed  Europe PubMed DOI  I
  32. Zeng,D., Ma,Y., Zhang,R., Nie,Q., Cui,Z., Wang,Y., Shang,L. and Yin,Z.
    Synthesis and structure-activity relationship of alpha-keto amides as enterovirus 71 3C protease inhibitors
    Bioorg Med Chem Lett (2016) 26, 1762-1766. PubMed  Europe PubMed DOI  I
  33. Zhai,Y., Ma,Y., Ma,F., Nie,Q., Ren,X., Wang,Y., Shang,L. and Yin,Z.
    Structure-activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors
    Eur J Med Chem (2016) 124, 559-573. PubMed  Europe PubMed DOI  I
  34. Zhang,L., Huang,G., Cai,Q., Zhao,C., Tang,L., Ren,H., Li,P., Li,N., Huang,J., Chen,X., Guan,Y., You,H., Chen,S., Li,J. and Lin,T.
    Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71
    J Mol Recognit (2016) 29, 520-527. PubMed  Europe PubMed DOI  I
    35. 2015
  35. Shang,L., Zhang,S., Yang,X., Sun,J., Li,L., Cui,Z., He,Q., Guo,Y., Sun,Y. and Yin,Z.
    Biochemical characterization of recombinant enterovirus 71 3C protease with fluorogenic model peptide substrates and development of a biochemical assay
    Antimicrob Agents Chemother (2015) 59, 1827-1836. PubMed  Europe PubMed DOI  A
  36. Song,J.H., Kwon,B.E., Jang,H., Kang,H., Cho,S., Park,K., Ko,H.J. and Kim,H.
    Antiviral activity of chrysin derivatives against coxsackievirus B3 in vitro and in vivo
    Biomol Ther (Seoul) (2015) 23, 465-470. PubMed  Europe PubMed DOI  PMC  EPMC  I
  37. Zhai,Y., Zhao,X., Cui,Z., Wang,M., Wang,Y., Li,L., Sun,Q., Yang,X., Zeng,D., Liu,Y., Sun,Y., Lou,Z., Shang,L. and Yin,Z.
    Cyanohydrin as an anchoring group for potent and selective inhibitors of enterovirus 71 3C protease
    J Med Chem (2015) 58, 9414-9420. PubMed  Europe PubMed DOI  I
    38. 2014
  38. Guo,Z., Zhong,X., Lin,L., Wu,S., Wang,T., Chen,Y., Zhai,X., Wang,Y., Wu,H., Tong,L., Han,Y., Pan,B., Peng,Y., Si,X., Zhang,F., Zhao,W. and Zhong,Z.
    A 3C(pro)-dependent bioluminescence imaging assay for in vivo evaluation of anti-enterovirus 71 agents
    Antiviral Res (2014) 101, 82-92. PubMed  Europe PubMed DOI  A
  39. Lei,X., Han,N., Xiao,X., Jin,Q., He,B. and Wang,J.
    Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex
    J Virol (2014) 88, 9830-9841. PubMed  Europe PubMed DOI
  40. Wang,J., Zhang,T., Du,J., Cui,S., Yang,F. and Jin,Q.
    Anti-enterovirus 71 effects of chrysin and its phosphate ester
    PLoS ONE (2014) 9, e89668-e89668. PubMed  Europe PubMed DOI  PMC  EPMC  I
  41. Wang,J., Su,H., Zhang,T., Du,J., Cui,S., Yang,F. and Jin,Q.
    Inhibition of enterovirus 71 replication by 7-hydroxyflavone and diisopropyl-flavon7-yl phosphate
    PLoS ONE (2014) 9, e92565-e92565. PubMed  Europe PubMed DOI  PMC  EPMC  I
  42. Xiang,Z., Li,L., Lei,X., Zhou,H., Zhou,Z., He,B. and Wang,J.
    Enterovirus 68 3C protease cleaves TRIF to attenuate antiviral responses mediated by Toll-like receptor 3
    J Virol (2014) 88, 6650-6659. PubMed  Europe PubMed DOI
    43. 2013
  43. Huang,S., Lyu,Y., Qing,X., Wang,W., Tang,L., Cheng,K. and Wang,W.
    Autoprocessing: an essential step for expression and purification of enterovirus 71 3C(pro) in Escherichia coli
    Biotechnol Lett (2013) 35, 1845-1852. PubMed  Europe PubMed DOI  A  E
  44. Mandadapu,S.R., Weerawarna,P.M., Prior,A.M., Uy,R.A., Aravapalli,S., Alliston,K.R., Lushington,G.H., Kim,Y., Hua,D.H., Chang,K.O. and Groutas,W.C.
    Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus
    Bioorg Med Chem Lett (2013) 23, 3709-3712. PubMed  Europe PubMed DOI  I
  45. Wu,C., Cai,Q., Chen,C., Li,N., Peng,X., Cai,Y., Yin,K., Chen,X., Wang,X., Zhang,R., Liu,L., Chen,S., Li,J. and Lin,T.
    Structures of enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir
    Acta Crystallogr D Biol Crystallogr (2013) 69, 866-871. PubMed  Europe PubMed DOI  S  I
    46. 2012
  46. Chen,L., Yang,Z.J., Zhou,Z., Cai,W.T., Teng,X.Z. and Zhang,G.X.
    [Expression and activity analysis of enterovirus 71 3C protease in Escherichia coli]
    Bing Du Xue Bao (2012) 28, 195-200. PubMed  Europe PubMed  E
  47. Lin,Y.J., Chang,Y.C., Hsiao,N.W., Hsieh,J.L., Wang,C.Y., Kung,S.H., Tsai,F.J., Lan,Y.C. and Lin,C.W.
    Fisetin and rutin as 3C protease inhibitors of enterovirus A71
    J Virol Methods (2012) 182, 93-98. PubMed  Europe PubMed DOI  I
  48. Wang,J., Lei,X. and Cui,S.
    Human enterovirus 71 picornain 3C
    [ISSN:978-0-12-407743-0] (2012) 3, 2423-2426. DOI
    49. 2011
  49. Chen,S.C., Chang,L.Y., Wang,Y.W., Chen,Y.C., Weng,K.F., Shih,S.R. and Shih,H.M.
    Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis
    J Biol Chem (2011) 286, 31373-31384. PubMed  Europe PubMed DOI
  50. Cui,S., Wang,J., Fan,T., Qin,B., Guo,L., Lei,X., Wang,J., Wang,M. and Jin,Q.
    Crystal structure of human enterovirus 71 3C protease
    J Mol Biol (2011) 408, 449-461. PubMed  Europe PubMed DOI  S
  51. Lei,X., Sun,Z., Liu,X., Jin,Q., He,B. and Wang,J.
    Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by toll-like receptor 3
    J Virol (2011) 85, 8811-8818. PubMed  Europe PubMed DOI
  52. Lu,G., Qi,J., Chen,Z., Xu,X., Gao,F., Lin,D., Qian,W., Liu,H., Jiang,H., Yan,J. and Gao,G.F.
    Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design
    J Virol (2011) 85, 10319-10331. PubMed  Europe PubMed DOI  S  I
    53. 2010
  53. Lei,X., Liu,X., Ma,Y., Sun,Z., Yang,Y., Jin,Q., He,B. and Wang,J.
    The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses
    J Virol (2010) 84, 8051-8061. PubMed  Europe PubMed DOI  PMC  EPMC
    54. 2009
  54. Tsai,M.T., Cheng,Y.H., Liu,Y.N., Liao,N.C., Lu,W.W. and Kung,S.H.
    Real-time monitoring of human enterovirus (HEV)-infected cells and anti-HEV 3C protease potency by fluorescence resonance energy transfer
    Antimicrobial Agents Chemother (2009) 53, 748-755. PubMed  Europe PubMed DOI  PMC  EPMC  A  L
  55. Weng,K.F., Li,M.L., Hung,C.T. and Shih,S.R.
    Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation
    PLoS Pathog (2009) 5, e1000593-e1000593. PubMed  Europe PubMed DOI  PMC  EPMC  P
    56. 2008
  56. Kuo,C.J., Shie,J.J., Fang,J.M., Yen,G.R., Hsu,J.T., Liu,H.G., Tseng,S.N., Chang,S.C., Lee,C.Y., Shih,S.R. and Liang,P.H.
    Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents
    Bioorg Med Chem (2008) 16, 7388-7398. PubMed  Europe PubMed DOI  I
  57. Lee,J.C., Shih,S.R., Chang,T.Y., Tseng,H.Y., Shih,Y.F., Yen,K.J., Chen,W.C., Shie,J.J., Fang,J.M., Liang,P.H., Chao,Y.S. and Hsu,J.T.
    A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71
    Anal Biochem (2008) 375, 115-123. PubMed  Europe PubMed DOI
    58. 2005
  58. Binford,S.L., Maldonado,F., Brothers,M.A., Weady,P.T., Zalman,L.S., Meador,J.W., III, Matthews,D.A. and Patick,A.K.
    Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor
    Antimicrob Agents Chemother (2005) 49, 619-626. PubMed  Europe PubMed DOI  PMC  EPMC  I
    59. 2004
  59. Shih,S.R., Chiang,C., Chen,T.C., Wu,C.N., Hsu,J.T., Lee,J.C., Hwang,M.J., Li,M.L., Chen,G.W. and Ho,M.S.
    Mutations at KFRDI and VGK domains of enterovirus 71 3C protease affect its RNA binding and proteolytic activities
    J Biomed Sci (2004) 11, 239-248. PubMed  Europe PubMed DOI
    60. 2002
  60. [YEAR:15-2-2002]Li,M.L., Hsu,T.A., Chen,T.C., Chang,S.C., Lee,J.C., Chen,C.C., Stollar,V. and Shih,S.R.
    The 3C protease activity of enterovirus 71 induces human neural cell apoptosis
    Virology (15-2-2002) 293, 386-395. PubMed  Europe PubMed DOI  I

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