Literature for peptidase C03.014: human enterovirus 71 3C peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, P Specificity, K Knockout, E Expression, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Hu,S., Zhong,Q., Xie,X., Zhang,S., Wang,J., Liu,H. and Dai,W. Research progress on critical viral protease inhibitors for coronaviruses and enteroviruses Bioorg Med Chem Lett (2025) 122, 130168-130168. PubMed Europe PubMed DOI
Ye,J., Zhang,R., Liu,X. and Chen,Y. Production of a genetically encoded biosensor for evaluating enterovirus 71 3C protease inhibitors Prep Biochem Biotechnol (2025) , 1-6. PubMed Europe PubMed DOI I

2024

Jassey,A., Paudel,B., Wagner,M.A., Pollack,N., Cheng,I.T., Godoy-Ruiz,R., Weber,D.J. and Jackson,W.T. Mitophagosomes induced during EV-D68 infection promote viral nonlytic release bioRxiv (2024) PubMed Europe PubMed DOI PMC EPMC
Li,H., Song,J., Deng,Z., Yao,Y., Qiao,W. and Tan,J. Cleavage of Stau2 by 3C protease promotes EV-A71 replication Virol J (2024) 21, 216-216. PubMed Europe PubMed DOI PMC EPMC K
Zhang,D., Xie,Y., Cao,J., Huang,L. and Fan,W. Enteroviral 3C protease cleaves N4BP1 to impair the host inflammatory response J Virol (2024) , e0175824-e0175824. PubMed Europe PubMed DOI

2022

Primavera,V., Simmons,J., Clark,B.A., Neilan,J.G. and Puckette,M. Effect of Foot-and-Mouth Disease Virus 2B Viroporin on Expression and Extraction of Mammalian Cell Culture Produced Foot-and-Mouth Disease Virus-like Particles Vaccines (Basel) (2022) 10 PubMed Europe PubMed DOI PMC EPMC

2021

Li,Z., Wu,Y., Li,H., Li,W., Tan,J. and Qiao,W. 3C protease of enterovirus 71 cleaves promyelocytic leukemia protein and impairs PML-NBs production Virol J (2021) 18, 255-255. PubMed Europe PubMed DOI PMC EPMC
Wo,X., Yuan,Y., Xu,Y., Chen,Y., Wang,Y., Zhao,S., Lin,L., Zhong,X., Wang,Y., Zhong,Z. and Zhao,W. TAR DNA-Binding Protein 43 is Cleaved by the Protease 3C of Enterovirus A71 Virol Sin (2021) 36, 95-103. PubMed Europe PubMed DOI

2020

Wen,W., Qi,Z. and Wang,J. The Function and Mechanism of Enterovirus 71 (EV71) 3C Protease Curr Microbiol (2020) 77, 1968-1975. PubMed Europe PubMed DOI

2019

Cao,J., Liu,H., Qu,M., Hou,A., Zhou,Y., Sun,B., Cai,L., Gao,F., Su,W. and Jiang,C. Determination of the cleavage site of enterovirus 71 VP0 and the effect of this cleavage on viral infectivity and assembly Microb Pathog (2019) 134, 103568-103568. PubMed Europe PubMed DOI
Li,M.L., Lin,J.Y., Chen,B.S., Weng,K.F., Shih,S.R., Calderon,J.D., Tolbert,B.S. and Brewer,G. EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation PLoS ONE (2019) 14, e0221048-e0221048. PubMed Europe PubMed DOI
Ma,Y., Li,L., He,S., Shang,C., Sun,Y., Liu,N., Meek,T.D., Wang,Y. and Shang,L. Application of dually activated Michael acceptor to the rational design of reversible covalent inhibitor for enterovirus 71 3C protease J Med Chem (2019) 62, 6146-6162. PubMed Europe PubMed DOI I

2018

Fu,S., Nie,Q., Ma,Y., Song,P., Ren,X., Luo,C., Shang,L. and Yin,Z. Target-guided screening of fragments (TGSOF) in the discovery of inhibitors against EV-A71 3C protease Chem Commun (Camb) (2018) 54, 2890-2893. PubMed Europe PubMed DOI I
Ma,Y., Shang,C., Yang,P., Li,L., Zhai,Y., Yin,Z., Wang,B. and Shang,L. 4-Iminooxazolidin-2-one as a bioisostere of the cyanohydrin moiety: inhibitors of enterovirus 71 3C protease J Med Chem (2018) 61, 10333-10339. PubMed Europe PubMed DOI I
Nie,Q., Xu,X., Zhang,Q., Ma,Y., Yin,Z. and Shang,L. 3D-Quantitative structure-activity relationship study for the design of novel enterovirus A71 3C protease inhibitors Chem Biol Drug Des (2018) 92, 1750-1762. PubMed Europe PubMed DOI I
Rasti,M., Khanbabaei,H. and Teimoori,A. An update on enterovirus 71 infection and interferon type I response Rev Med Virol (2018) , e2016-e2016. PubMed Europe PubMed DOI
Xie,L., Lu,B., Zheng,Z., Miao,Y., Liu,Y., Zhang,Y., Zheng,C., Ke,X., Hu,Q. and Wang,H. The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP) J Gen Virol (2018) 99, 73-85. PubMed Europe PubMed DOI
Yao,C., Xi,C., Hu,K., Gao,W., Cai,X., Qin,J., Lv,S., Du,C. and Wei,Y. Inhibition of enterovirus 71 replication and viral 3C protease by quercetin Virol J (2018) 15, 116-116. PubMed Europe PubMed DOI PMC EPMC I

2017

Lei,X., Zhang,Z., Xiao,X., Qi,J., He,B. and Wang,J. Enterovirus 71 inhibits pyroptosis through cleavage of GSDMD J Virol (2017) 91, e01069-17-e01069-17. PubMed Europe PubMed DOI
Li,B., Yue,Y., Zhang,Y., Yuan,Z., Li,P., Song,N., Lin,W., Liu,Y., Gu,L. and Meng,H. A novel enterovirus 71 (EV71) virulence determinant: the 69th residue of 3C protease modulates pathogenicity Front Cell Infect Microbiol (2017) 7, 26-26. PubMed Europe PubMed DOI PMC EPMC S
Li,J., Yao,Y., Chen,Y., Xu,X., Lin,Y., Yang,Z., Qiao,W. and Tan,J. Enterovirus 71 3C promotes apoptosis through cleavage of PinX1, a telomere binding protein J Virol (2017) 91, e02016-16-e02016-16. PubMed Europe PubMed DOI
Rui,Y., Su,J., Wang,H., Chang,J., Wang,S., Zheng,W., Cai,Y., Wei,W., Gordy,J.T., Markham,R., Kong,W., Zhang,W. and Yu,X.F. Disruption of MDA5 mediated innate immune responses by the 3C proteins of Coxsackievirus A16, Coxsackievirus A6, and Enterovirus D68 J Virol (2017) DOI
Wang,Y., Cao,L., Zhai,Y., Ma,J., Nie,Q., Li,T., Yin,Z., Sun,Y. and Shang,L. Inhibition of enterovirus 71 replication by an alpha-hydroxy-nitrile derivative NK-1.9k Antiviral Res (2017) 141, 91-100. PubMed Europe PubMed DOI I
Zhang,Y., Ke,X., Zheng,C., Liu,Y., Xie,L., Zheng,Z. and Wang,H. Development of a luciferase-based biosensor to assess enterovirus 71 3C protease activity in living cells Sci Rep (2017) 7, 10385-10385. PubMed Europe PubMed DOI PMC EPMC A L

2016

Ang,M.J., Lau,Q.Y., Ng,F.M., Then,S.W., Poulsen,A., Cheong,Y.K., Ngoh,Z.X., Tan,Y.W., Peng,J., Keller,T.H., Hill,J., Chu,J.J. and Brian Chia,C.S. Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study J Enzyme Inhib Med Chem (2016) 31, 332-339. PubMed Europe PubMed DOI I
Cao,Z., Ding,Y., Ke,Z., Cao,L., Li,N., Ding,G., Wang,Z. and Xiao,W. Luteoloside acts as 3C protease inhibitor of enterovirus 71 in vitro PLoS ONE (2016) 11, e0148693-e0148693. PubMed Europe PubMed DOI I
Jetsadawisut,W., Nutho,B., Meeprasert,A., Rungrotmongkol,T., Kungwan,N., Wolschann,P. and Hannongbua,S. Susceptibility of inhibitors against 3C protease of coxsackievirus A16 and enterovirus A71 causing hand, foot and mouth disease: a molecular dynamics study Biophys Chem (2016) 219, 9-16. PubMed Europe PubMed DOI I
Li,P., Yue,Y., Song,N., Li,B., Meng,H., Yang,G., Li,Z., An,L. and Qin,L. Genome analysis of enterovirus 71 strains differing in mouse pathogenicity Virus Genes (2016) 52, 161-171. PubMed Europe PubMed DOI M
Ma,G.H., Ye,Y., Zhang,D., Xu,X., Si,P., Peng,J.L., Xiao,Y.L., Cao,R.Y., Yin,Y.L., Chen,J., Zhao,L.X., Zhou,Y., Zhong,W., Liu,H., Luo,X.M., Chen,L.L. and Shen,X. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening Eur J Med Chem (2016) 124, 981-991. PubMed Europe PubMed DOI I
Tan,Y.W., Ang,M.J., Lau,Q.Y., Poulsen,A., Ng,F.M., Then,S.W., Peng,J., Hill,J., Hong,W.J., Chia,C.S. and Chu,J.J. Antiviral activities of peptide-based covalent inhibitors of the enterovirus 71 3C protease Sci Rep (2016) 6, 33663-33663. PubMed Europe PubMed DOI PMC EPMC I
Wu,C., Zhang,L., Li,P., Cai,Q., Peng,X., Yin,K., Chen,X., Ren,H., Zhong,S., Weng,Y., Guan,Y., Chen,S., Wu,J., Li,J. and Lin,T. Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71 Biochim Biophys Acta (2016) 1860, 1299-1307. PubMed Europe PubMed DOI I
Zeng,D., Ma,Y., Zhang,R., Nie,Q., Cui,Z., Wang,Y., Shang,L. and Yin,Z. Synthesis and structure-activity relationship of alpha-keto amides as enterovirus 71 3C protease inhibitors Bioorg Med Chem Lett (2016) 26, 1762-1766. PubMed Europe PubMed DOI I
Zhai,Y., Ma,Y., Ma,F., Nie,Q., Ren,X., Wang,Y., Shang,L. and Yin,Z. Structure-activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors Eur J Med Chem (2016) 124, 559-573. PubMed Europe PubMed DOI I
Zhang,L., Huang,G., Cai,Q., Zhao,C., Tang,L., Ren,H., Li,P., Li,N., Huang,J., Chen,X., Guan,Y., You,H., Chen,S., Li,J. and Lin,T. Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71 J Mol Recognit (2016) 29, 520-527. PubMed Europe PubMed DOI I

2015

Shang,L., Zhang,S., Yang,X., Sun,J., Li,L., Cui,Z., He,Q., Guo,Y., Sun,Y. and Yin,Z. Biochemical characterization of recombinant enterovirus 71 3C protease with fluorogenic model peptide substrates and development of a biochemical assay Antimicrob Agents Chemother (2015) 59, 1827-1836. PubMed Europe PubMed DOI A
Song,J.H., Kwon,B.E., Jang,H., Kang,H., Cho,S., Park,K., Ko,H.J. and Kim,H. Antiviral activity of chrysin derivatives against coxsackievirus B3 in vitro and in vivo Biomol Ther (Seoul) (2015) 23, 465-470. PubMed Europe PubMed DOI PMC EPMC I
Zhai,Y., Zhao,X., Cui,Z., Wang,M., Wang,Y., Li,L., Sun,Q., Yang,X., Zeng,D., Liu,Y., Sun,Y., Lou,Z., Shang,L. and Yin,Z. Cyanohydrin as an anchoring group for potent and selective inhibitors of enterovirus 71 3C protease J Med Chem (2015) 58, 9414-9420. PubMed Europe PubMed DOI I

2014

Guo,Z., Zhong,X., Lin,L., Wu,S., Wang,T., Chen,Y., Zhai,X., Wang,Y., Wu,H., Tong,L., Han,Y., Pan,B., Peng,Y., Si,X., Zhang,F., Zhao,W. and Zhong,Z. A 3C(pro)-dependent bioluminescence imaging assay for in vivo evaluation of anti-enterovirus 71 agents Antiviral Res (2014) 101, 82-92. PubMed Europe PubMed DOI A
Lei,X., Han,N., Xiao,X., Jin,Q., He,B. and Wang,J. Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex J Virol (2014) 88, 9830-9841. PubMed Europe PubMed DOI
Wang,J., Zhang,T., Du,J., Cui,S., Yang,F. and Jin,Q. Anti-enterovirus 71 effects of chrysin and its phosphate ester PLoS ONE (2014) 9, e89668-e89668. PubMed Europe PubMed DOI PMC EPMC I
Wang,J., Su,H., Zhang,T., Du,J., Cui,S., Yang,F. and Jin,Q. Inhibition of enterovirus 71 replication by 7-hydroxyflavone and diisopropyl-flavon7-yl phosphate PLoS ONE (2014) 9, e92565-e92565. PubMed Europe PubMed DOI PMC EPMC I
Xiang,Z., Li,L., Lei,X., Zhou,H., Zhou,Z., He,B. and Wang,J. Enterovirus 68 3C protease cleaves TRIF to attenuate antiviral responses mediated by Toll-like receptor 3 J Virol (2014) 88, 6650-6659. PubMed Europe PubMed DOI

2013

Huang,S., Lyu,Y., Qing,X., Wang,W., Tang,L., Cheng,K. and Wang,W. Autoprocessing: an essential step for expression and purification of enterovirus 71 3C(pro) in Escherichia coli Biotechnol Lett (2013) 35, 1845-1852. PubMed Europe PubMed DOI A E
Mandadapu,S.R., Weerawarna,P.M., Prior,A.M., Uy,R.A., Aravapalli,S., Alliston,K.R., Lushington,G.H., Kim,Y., Hua,D.H., Chang,K.O. and Groutas,W.C. Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus Bioorg Med Chem Lett (2013) 23, 3709-3712. PubMed Europe PubMed DOI I
Wu,C., Cai,Q., Chen,C., Li,N., Peng,X., Cai,Y., Yin,K., Chen,X., Wang,X., Zhang,R., Liu,L., Chen,S., Li,J. and Lin,T. Structures of enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir Acta Crystallogr D Biol Crystallogr (2013) 69, 866-871. PubMed Europe PubMed DOI S I

2012

Chen,L., Yang,Z.J., Zhou,Z., Cai,W.T., Teng,X.Z. and Zhang,G.X. [Expression and activity analysis of enterovirus 71 3C protease in Escherichia coli] Bing Du Xue Bao (2012) 28, 195-200. PubMed Europe PubMed E
Lin,Y.J., Chang,Y.C., Hsiao,N.W., Hsieh,J.L., Wang,C.Y., Kung,S.H., Tsai,F.J., Lan,Y.C. and Lin,C.W. Fisetin and rutin as 3C protease inhibitors of enterovirus A71 J Virol Methods (2012) 182, 93-98. PubMed Europe PubMed DOI I
Wang,J., Lei,X. and Cui,S. Human enterovirus 71 picornain 3C [ISSN:978-0-12-407743-0] (2012) 3, 2423-2426. DOI

2011

Chen,S.C., Chang,L.Y., Wang,Y.W., Chen,Y.C., Weng,K.F., Shih,S.R. and Shih,H.M. Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis J Biol Chem (2011) 286, 31373-31384. PubMed Europe PubMed DOI
Cui,S., Wang,J., Fan,T., Qin,B., Guo,L., Lei,X., Wang,J., Wang,M. and Jin,Q. Crystal structure of human enterovirus 71 3C protease J Mol Biol (2011) 408, 449-461. PubMed Europe PubMed DOI S
Lei,X., Sun,Z., Liu,X., Jin,Q., He,B. and Wang,J. Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by toll-like receptor 3 J Virol (2011) 85, 8811-8818. PubMed Europe PubMed DOI
Lu,G., Qi,J., Chen,Z., Xu,X., Gao,F., Lin,D., Qian,W., Liu,H., Jiang,H., Yan,J. and Gao,G.F. Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design J Virol (2011) 85, 10319-10331. PubMed Europe PubMed DOI S I

2010

Lei,X., Liu,X., Ma,Y., Sun,Z., Yang,Y., Jin,Q., He,B. and Wang,J. The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses J Virol (2010) 84, 8051-8061. PubMed Europe PubMed DOI PMC EPMC

2009

Tsai,M.T., Cheng,Y.H., Liu,Y.N., Liao,N.C., Lu,W.W. and Kung,S.H. Real-time monitoring of human enterovirus (HEV)-infected cells and anti-HEV 3C protease potency by fluorescence resonance energy transfer Antimicrobial Agents Chemother (2009) 53, 748-755. PubMed Europe PubMed DOI PMC EPMC A L
Weng,K.F., Li,M.L., Hung,C.T. and Shih,S.R. Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation PLoS Pathog (2009) 5, e1000593-e1000593. PubMed Europe PubMed DOI PMC EPMC P

2008

Kuo,C.J., Shie,J.J., Fang,J.M., Yen,G.R., Hsu,J.T., Liu,H.G., Tseng,S.N., Chang,S.C., Lee,C.Y., Shih,S.R. and Liang,P.H. Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents Bioorg Med Chem (2008) 16, 7388-7398. PubMed Europe PubMed DOI I
Lee,J.C., Shih,S.R., Chang,T.Y., Tseng,H.Y., Shih,Y.F., Yen,K.J., Chen,W.C., Shie,J.J., Fang,J.M., Liang,P.H., Chao,Y.S. and Hsu,J.T. A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71 Anal Biochem (2008) 375, 115-123. PubMed Europe PubMed DOI

2005

Binford,S.L., Maldonado,F., Brothers,M.A., Weady,P.T., Zalman,L.S., Meador,J.W., III, Matthews,D.A. and Patick,A.K. Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor Antimicrob Agents Chemother (2005) 49, 619-626. PubMed Europe PubMed DOI PMC EPMC I

2004

Shih,S.R., Chiang,C., Chen,T.C., Wu,C.N., Hsu,J.T., Lee,J.C., Hwang,M.J., Li,M.L., Chen,G.W. and Ho,M.S. Mutations at KFRDI and VGK domains of enterovirus 71 3C protease affect its RNA binding and proteolytic activities J Biomed Sci (2004) 11, 239-248. PubMed Europe PubMed DOI

2002

[YEAR:15-2-2002]Li,M.L., Hsu,T.A., Chen,T.C., Chang,S.C., Lee,J.C., Chen,C.C., Stollar,V. and Shih,S.R. The 3C protease activity of enterovirus 71 induces human neural cell apoptosis Virology (15-2-2002) 293, 386-395. PubMed Europe PubMed DOI I