Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q13148

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
32	cathepsin L	7-42	N		MS	Biniossek et al., 2011
70	matrix metallopeptidase-2	55-79	N		MS	Schilling & Overall, 2008
79	trypsin 1	1-414	N		MS	Schilling & Overall, 2008
89	caspase-3	1-414	P		MS	Impens et al., 2010
89	caspase-7	1-414	P		MU	Suzuki et al., 2011
89	caspase-12	1-414	P		MU	Suzuki et al., 2011
169	caspase-3	1-414	P		MU	Suzuki et al., 2011
169	caspase-7	1-414	P		MU	Suzuki et al., 2011
169	caspase-12	1-414	P		MU	Suzuki et al., 2011
251	trypsin 1	1-414	N		MS	Schilling & Overall, 2008
263	trypsin 1	1-414	N		MS	Schilling & Overall, 2008
340	cathepsin S	294-301	N		MS	Biniossek et al., 2011
341	cathepsin L	294-361	N		MS	Biniossek et al., 2011
341	cathepsin S	294-361	N		MS	Biniossek et al., 2011