Literature for peptidase C01.142: cathepsin L2 (Fasciola sp.)

Summary Alignment Sequences Sequence features Distribution Literature Substrates

(Topics flags: S Structure, P Specificity, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2021
  1. Cwiklinski,K., Robinson,M.W., Donnelly,S. and Dalton,J.P.
    Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver
    BMC Genomics22, 46-46. PubMed  Europe PubMed DOI
  2. Villa-Mancera,A., Alcala-Canto,Y., Olivares-Perez,J., Molina-Mendoza,P., Hernandez-Guzman,K., Utrera-Quintana,F., Carreon-Luna,L., Olmedo-Juarez,A. and Reynoso-Palomar,A.
    Vaccination with cathepsin L mimotopes of Fasciola hepatica in goats reduces worm burden, morphometric measurements, and reproductive structures
    Microb Pathog155, 104859-104859. PubMed  Europe PubMed DOI
  3. 2020
  4. Pritsch,I.C., Tikhonova,I.G., Jewhurst,H.L., Drysdale,O., Cwiklinski,K., Molento,M.B., Dalton,J.P. and Verissimo,C.M.
    Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed 'clamp-like' mechanism of binding and inhibition
    BMC Mol Cell Biol21, 90-90. PubMed  Europe PubMed DOI
  5. 2018
  6. Norbury,L.J., Basalaj,K., Zawistowska-Deniziak,A., Sielicka,A., Wilkowski,P., Wesolowska,A., Smooker,P.M. and Wedrychowicz,H.
    Intranasal delivery of a formulation containing stage-specific recombinant proteins of Fasciola hepatica cathepsin L5 and cathepsin B2 triggers an anti-fecundity effect and an adjuvant-mediated reduction in fluke burden in sheep
    Vet Parasitol258, 14-23. PubMed  Europe PubMed DOI
  7. 2015
  8. Meemon,K. and Sobhon,P.
    Juvenile-specific cathepsin proteases in Fasciola spp.: their characteristics and vaccine efficacies
    Parasitol Res114, 2807-2813. PubMed  Europe PubMed DOI
  9. 2014
  10. Ran,X.H., Wen,X.B., Wang,C.R., Li,X.J. and Wei,X.M.
    [Immunoreactivity and immunogenicity analysis of the recombinant cathepsin L-like protease of Fasciola hepatica in SD rats]
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi32, 289-292. PubMed  Europe PubMed
  11. 2012
  12. McVeigh,P., Maule,A.G., Dalton,J.P. and Robinson,M.W.
    Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective
    Microbes Infect14, 301-310. PubMed  Europe PubMed DOI
  13. Norbury,L.J., Hung,A., Beckham,S., Pike,R.N., Spithill,T.W., Craik,C.S., Choe,Y., Fecondo,J.V. and Smooker,P.M.
    Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference
    Biochimie94, 1119-1127. PubMed  Europe PubMed DOI  P
  14. Robinson,M.W., Brindley,P.J., McKerrow,J.H. and Dalton,J.P.
    Trematode cysteine endopeptidases
    [ISSN:978-0-12-407743-0]3, 1941-1949. DOI
  15. 2011
  16. Baspinar,S., Celik,V., Balik,D.T. and Kaplan,M.
    Regional differences in the amino acid sequences of Fasciola hepatica cathepsin L2 from a Turkish isolate
    Balkan Med J28, 269-273. DOI
  17. Morphew,R.M., Wright,H.A., Lacourse,E.J., Porter,J., Barrett,J., Woods,D.J. and Brophy,P.M.
    Towards delineating functions within the Fasciola secreted cathepsin L protease family by integrating in vivo based sub-proteomics and phylogenetics
    PLoS Negl Trop Dis5, e937-e937. PubMed  Europe PubMed DOI
  18. Norbury,L.J., Beckham,S., Pike,R.N., Grams,R., Spithill,T.W., Fecondo,J.V. and Smooker,P.M.
    Adult and juvenile Fasciola cathepsin L proteases: different enzymes for different roles
    Biochimie93, 604-611. PubMed  Europe PubMed DOI  P
  19. Robinson,M.W., Corvo,I., Jones,P.M., George,A.M., Padula,M.P., To,J., Cancela,M., Rinaldi,G., Tort,J.F., Roche,L. and Dalton,J.P.
    Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica
    PLoS Negl Trop Dis5, e1012-e1012. PubMed  Europe PubMed DOI
  20. 2008
  21. Robinson,M.W., Dalton,J.P. and Donnelly,S.
    Helminth pathogen cathepsin proteases: it's a family affair
    Trends Biochem Sci33, 601-608. PubMed  Europe PubMed DOI  V
  22. Stack,C.M., Caffrey,C.R., Donnelly,S.M., Seshaadri,A., Lowther,J., Tort,J.F., Collins,P.R., Robinson,M.W., Xu,W., McKerrow,J.H., Craik,C.S., Geiger,S.R., Marion,R., Brinen,L.S. and Dalton,J.P.
    Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica
    J Biol Chem283, 9896-9908. PubMed  Europe PubMed DOI  S
  23. 2007
  24. Stack,C.M., Donnelly,S., Lowther,J., Xu,W., Collins,P.R., Brinen,L.S. and Dalton,J.P.
    The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: A leu-12 to pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removal
    J Biol Chem282, 16532-16543. PubMed  Europe PubMed DOI
  25. 2003
  26. [YEAR:30-9-2003]Dalton,J.P., Neill,S.O., Stack,C., Collins,P., Walshe,A., Sekiya,M., Doyle,S., Mulcahy,G., Hoyle,D., Khaznadji,E., Moire,N., Brennan,G., Mousley,A., Kreshchenko,N., Maule,A.G. and Donnelly,S.M.
    Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines
    Int J Parasitol33, 1173-1181. PubMed  Europe PubMed DOI
  27. 2001
  28. [YEAR:3-9-2001]Cordova,M., Jara,J., Del Nery,E., Hirata,I.Y., Araujo,M.S., Carmona,A.K., Juliano,M.A. and Juliano,L.
    Characterization of two cysteine proteinases secreted by Fasciola hepatica and demonstration of their kininogenase activity
    Mol Biochem Parasitol116, 109-115. PubMed  Europe PubMed DOI
  29. Mulcahy,G. and Dalton,J.P.
    Cathepsin L proteinases as vaccines against infection with Fasciola hepatica (liver fluke) in ruminants
    Res Vet Sci70, 83-86. PubMed  Europe PubMed DOI
  30. 2000
  31. Berasain,P., Carmona,C., Frangione,B., Dalton,J.P. and Goni,F.
    Fasciola hepatica: parasite-secreted proteinases degrade all human IgG subclasses: determination of the specific cleavage sites and identification of the immunoglobulin fragments produced
    Exp Parasitol94, 99-110. PubMed  Europe PubMed DOI
  32. 1999
  33. Piacenza,L., Acosta,D., Basmadjian,I., Dalton,J.P. and Carmona,C.
    Vaccination with cathepsin L proteinases and with leucine aminopeptidase induces high levels of protection against fascioliasis in sheep
    Infect Immun67, 1954-1961. PubMed  Europe PubMed
  34. Tort,J., Brindley,P.J., Knox,D., Wolfe,K.H. and Dalton,J.P.
    Proteinases and associated genes of parasitic helminths
    Adv Parasitol43, 161-266. PubMed  Europe PubMed  V
  35. 1998
  36. Mulcahy,G., O'Connor,F., McGonigle,S., Dowd,A., Clery,D.G., Andrews,S.J. and Dalton,J.P.
    Correlation of specific antibody titre and avidity with protection in cattle immunized against Fasciola hepatica
    Vaccine16, 932-939. PubMed  Europe PubMed DOI
  37. 1997
  38. Berasain,P., Goni,F., McGonigle,S., Dowd,A., Dalton,J.P., Frangione,B. and Carmona,C.
    Proteinases secreted by Fasciola hepatica degrade extracellular matrix and basement membrane components
    J Parasitol83, 1-5. PubMed  Europe PubMed DOI
  39. Dowd,A.J., Tort,J., Roche,L., Ryan,T. and Dalton,J.P.
    Isolation of a cDNA encoding Fasciola hepatica cathepsin L2 and functional expression in Saccharomyces cerevisiae
    Mol Biochem Parasitol88, 163-174. PubMed  Europe PubMed DOI  E
  40. 1996
  41. Dalton,J.P., McGonigle,S., Rolph,T.P. and Andrews,S.J.
    Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin
    Infect Immun64, 5066-5074. PubMed  Europe PubMed