Literature for peptidase C01.142: cathepsin L2 (Fasciola sp.)

Summary Alignment Sequences Sequence features Distribution Literature Substrates

(Topics flags: S Structure, P Specificity, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2021

Cwiklinski,K., Robinson,M.W., Donnelly,S. and Dalton,J.P. Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver BMC Genomics (2021) 22, 46-46. PubMed Europe PubMed DOI PMC EPMC
Villa-Mancera,A., Alcala-Canto,Y., Olivares-Perez,J., Molina-Mendoza,P., Hernandez-Guzman,K., Utrera-Quintana,F., Carreon-Luna,L., Olmedo-Juarez,A. and Reynoso-Palomar,A. Vaccination with cathepsin L mimotopes of Fasciola hepatica in goats reduces worm burden, morphometric measurements, and reproductive structures Microb Pathog (2021) 155, 104859-104859. PubMed Europe PubMed DOI

2020

Pritsch,I.C., Tikhonova,I.G., Jewhurst,H.L., Drysdale,O., Cwiklinski,K., Molento,M.B., Dalton,J.P. and Verissimo,C.M. Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed 'clamp-like' mechanism of binding and inhibition BMC Mol Cell Biol (2020) 21, 90-90. PubMed Europe PubMed DOI PMC EPMC

2018

Norbury,L.J., Basalaj,K., Zawistowska-Deniziak,A., Sielicka,A., Wilkowski,P., Wesolowska,A., Smooker,P.M. and Wedrychowicz,H. Intranasal delivery of a formulation containing stage-specific recombinant proteins of Fasciola hepatica cathepsin L5 and cathepsin B2 triggers an anti-fecundity effect and an adjuvant-mediated reduction in fluke burden in sheep Vet Parasitol (2018) 258, 14-23. PubMed Europe PubMed DOI

2015

Meemon,K. and Sobhon,P. Juvenile-specific cathepsin proteases in Fasciola spp.: their characteristics and vaccine efficacies Parasitol Res (2015) 114, 2807-2813. PubMed Europe PubMed DOI

2014

Ran,X.H., Wen,X.B., Wang,C.R., Li,X.J. and Wei,X.M. [Immunoreactivity and immunogenicity analysis of the recombinant cathepsin L-like protease of Fasciola hepatica in SD rats] Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2014) 32, 289-292. PubMed Europe PubMed

2012

McVeigh,P., Maule,A.G., Dalton,J.P. and Robinson,M.W. Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective Microbes Infect (2012) 14, 301-310. PubMed Europe PubMed DOI
Norbury,L.J., Hung,A., Beckham,S., Pike,R.N., Spithill,T.W., Craik,C.S., Choe,Y., Fecondo,J.V. and Smooker,P.M. Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference Biochimie (2012) 94, 1119-1127. PubMed Europe PubMed DOI P
Robinson,M.W., Brindley,P.J., McKerrow,J.H. and Dalton,J.P. Trematode cysteine endopeptidases [ISSN:978-0-12-407743-0] (2012) 3, 1941-1949. DOI

2011

Baspinar,S., Celik,V., Balik,D.T. and Kaplan,M. Regional differences in the amino acid sequences of Fasciola hepatica cathepsin L2 from a Turkish isolate Balkan Med J (2011) 28, 269-273. DOI
Morphew,R.M., Wright,H.A., Lacourse,E.J., Porter,J., Barrett,J., Woods,D.J. and Brophy,P.M. Towards delineating functions within the Fasciola secreted cathepsin L protease family by integrating in vivo based sub-proteomics and phylogenetics PLoS Negl Trop Dis (2011) 5, e937-e937. PubMed Europe PubMed DOI PMC EPMC
Norbury,L.J., Beckham,S., Pike,R.N., Grams,R., Spithill,T.W., Fecondo,J.V. and Smooker,P.M. Adult and juvenile Fasciola cathepsin L proteases: different enzymes for different roles Biochimie (2011) 93, 604-611. PubMed Europe PubMed DOI P
Robinson,M.W., Corvo,I., Jones,P.M., George,A.M., Padula,M.P., To,J., Cancela,M., Rinaldi,G., Tort,J.F., Roche,L. and Dalton,J.P. Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica PLoS Negl Trop Dis (2011) 5, e1012-e1012. PubMed Europe PubMed DOI PMC EPMC

2008

Robinson,M.W., Dalton,J.P. and Donnelly,S. Helminth pathogen cathepsin proteases: it's a family affair Trends Biochem Sci (2008) 33, 601-608. PubMed Europe PubMed DOI V
Stack,C.M., Caffrey,C.R., Donnelly,S.M., Seshaadri,A., Lowther,J., Tort,J.F., Collins,P.R., Robinson,M.W., Xu,W., McKerrow,J.H., Craik,C.S., Geiger,S.R., Marion,R., Brinen,L.S. and Dalton,J.P. Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica J Biol Chem (2008) 283, 9896-9908. PubMed Europe PubMed DOI S

2007

Stack,C.M., Donnelly,S., Lowther,J., Xu,W., Collins,P.R., Brinen,L.S. and Dalton,J.P. The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: A leu-12 to pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removal J Biol Chem (2007) 282, 16532-16543. PubMed Europe PubMed DOI

2003

[YEAR:30-9-2003]Dalton,J.P., Neill,S.O., Stack,C., Collins,P., Walshe,A., Sekiya,M., Doyle,S., Mulcahy,G., Hoyle,D., Khaznadji,E., Moire,N., Brennan,G., Mousley,A., Kreshchenko,N., Maule,A.G. and Donnelly,S.M. Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines Int J Parasitol (30-9-2003) 33, 1173-1181. PubMed Europe PubMed DOI

2001

[YEAR:3-9-2001]Cordova,M., Jara,J., Del Nery,E., Hirata,I.Y., Araujo,M.S., Carmona,A.K., Juliano,M.A. and Juliano,L. Characterization of two cysteine proteinases secreted by Fasciola hepatica and demonstration of their kininogenase activity Mol Biochem Parasitol (3-9-2001) 116, 109-115. PubMed Europe PubMed DOI
Mulcahy,G. and Dalton,J.P. Cathepsin L proteinases as vaccines against infection with Fasciola hepatica (liver fluke) in ruminants Res Vet Sci (2001) 70, 83-86. PubMed Europe PubMed DOI

2000

Berasain,P., Carmona,C., Frangione,B., Dalton,J.P. and Goni,F. Fasciola hepatica: parasite-secreted proteinases degrade all human IgG subclasses: determination of the specific cleavage sites and identification of the immunoglobulin fragments produced Exp Parasitol (2000) 94, 99-110. PubMed Europe PubMed DOI

1999

Piacenza,L., Acosta,D., Basmadjian,I., Dalton,J.P. and Carmona,C. Vaccination with cathepsin L proteinases and with leucine aminopeptidase induces high levels of protection against fascioliasis in sheep Infect Immun (1999) 67, 1954-1961. PubMed Europe PubMed PMC EPMC
Tort,J., Brindley,P.J., Knox,D., Wolfe,K.H. and Dalton,J.P. Proteinases and associated genes of parasitic helminths Adv Parasitol (1999) 43, 161-266. PubMed Europe PubMed V

1998

Mulcahy,G., O'Connor,F., McGonigle,S., Dowd,A., Clery,D.G., Andrews,S.J. and Dalton,J.P. Correlation of specific antibody titre and avidity with protection in cattle immunized against Fasciola hepatica Vaccine (1998) 16, 932-939. PubMed Europe PubMed DOI

1997

Berasain,P., Goni,F., McGonigle,S., Dowd,A., Dalton,J.P., Frangione,B. and Carmona,C. Proteinases secreted by Fasciola hepatica degrade extracellular matrix and basement membrane components J Parasitol (1997) 83, 1-5. PubMed Europe PubMed DOI
Dowd,A.J., Tort,J., Roche,L., Ryan,T. and Dalton,J.P. Isolation of a cDNA encoding Fasciola hepatica cathepsin L2 and functional expression in Saccharomyces cerevisiae Mol Biochem Parasitol (1997) 88, 163-174. PubMed Europe PubMed DOI E

1996

Dalton,J.P., McGonigle,S., Rolph,T.P. and Andrews,S.J. Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin Infect Immun (1996) 64, 5066-5074. PubMed Europe PubMed PMC EPMC