Summary for peptidase C01.142: cathepsin L2 (Fasciola sp.)

Summary Alignment Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Namecathepsin L2 (Fasciola sp.)
Other namesCL2, FhCatL2, FhCatL5, FheCL2
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.142
Holotypecathepsin L2 (Fasciola sp.) (Fasciola hepatica) (peptidase unit: 107-323), MERNUM MER0002302
History Identifier created: MEROPS 8.2 (4 August 2008)
Activity
Catalytic typeCysteine
NC-IUBMBNot yet included in IUBMB recommendations.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/gp/-/- (based on 54 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 9 11 13 9 9 14 9 12
Pro 7 4 7 8 3 11 9 7
Ala 8 8 2 1 4 0 5 5
Val 2 2 2 1 4 1 3 2
Leu 2 4 7 4 4 1 3 1
Ile 5 1 3 4 2 2 1 0
Met 1 0 0 2 1 0 0 0
Phe 0 1 1 2 1 2 1 1
Tyr 1 0 1 1 1 1 2 0
Trp 0 0 0 1 0 1 0 0
Ser 2 3 2 1 5 4 4 2
Thr 0 3 5 0 3 0 1 2
Cys 0 0 0 0 0 1 0 1
Asn 2 2 3 2 1 1 0 5
Gln 2 4 2 3 2 2 2 3
Asp 1 1 2 3 5 1 0 1
Glu 3 2 0 4 2 3 4 3
Lys 3 3 2 3 2 3 4 4
Arg 3 2 2 3 1 3 2 1
His 0 1 0 1 1 0 1 1