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Substrates for peptidase C01.062: cathepsin B-like peptidase (platyhelminth)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Boc-Gly-Pro-Arg-NHMec Boc-Gly-Pro-Arg+NHMec S Boc Gly Pro Arg AMC - - - Sripa et al., 2010
Boc-Val-Pro-Arg-NHMec Boc-Val-Pro-Arg+NHMec S Boc Val Pro Arg AMC - - - Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Asn10+Val-Peptide N MS Asp Lys Thr Asn Val Lys Ala Ala Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Gly16+Lys-Peptide N MS Ala Ala Trp Gly Lys Val Gly Ala Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Ala22+Gly-Peptide N MS Gly Ala His Ala Gly Glu Tyr Gly Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Gly26+Ala-Peptide N MS Gly Glu Tyr Gly Ala Glu Ala Leu Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Phe37+Pro-Peptide N MS Phe Leu Ser Phe Pro Thr Thr Lys Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Phe44+Pro-Peptide N MS Lys Thr Tyr Phe Pro His Phe Asp Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Phe47+Asp-Peptide N MS Phe Pro His Phe Asp Leu Ser His Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Asp48+Leu-Peptide N MS Pro His Phe Asp Leu Ser His Gly Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Gly60+Lys-Peptide N MS Lys Gly His Gly Lys Lys Val Ala Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Thr68+Asn-Peptide N MS Asp Ala Leu Thr Asn Ala Val Ala Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Leu81+Ser-Peptide N MS Pro Asn Ala Leu Ser Ala Leu Ser Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Leu92+Arg-Peptide N MS Ala His Lys Leu Arg Val Asp Pro Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Asn98+Phe-Peptide N MS Asp Pro Val Asn Phe Lys Leu Leu Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Phe99+Lys-Peptide N MS Pro Val Asn Phe Lys Leu Leu Ser Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Cys105+Leu-Peptide N MS Leu Ser His Cys Leu Leu Val Thr Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Leu107+Val-Peptide N MS His Cys Leu Leu Val Thr Leu Ala Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Ala121+Val-Peptide N MS Phe Thr Pro Ala Val His Ala Ser Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Ala124+Ser-Peptide N MS Ala Val His Ala Ser Leu Asp Lys Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Ala131+Ser-Peptide N MS Lys Phe Leu Ala Ser Val Ser Thr Sripa et al., 2010
Hemoglobin subunit alpha P69905 2-142 Peptide-Ser132+Val-Peptide N MS Phe Leu Ala Ser Val Ser Thr Val Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Ser10+Ala-Peptide N MS Glu Glu Lys Ser Ala Val Thr Ala Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Thr13+Ala-Peptide N MS Ser Ala Val Thr Ala Leu Trp Gly Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Leu15+Trp-Peptide N MS Val Thr Ala Leu Trp Gly Lys Val Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Trp16+Gly-Peptide N MS Thr Ala Leu Trp Gly Lys Val Asn Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Gly17+Lys-Peptide N MS Ala Leu Trp Gly Lys Val Asn Val Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Tyr36+Pro-Peptide N MS Leu Val Val Tyr Pro Trp Thr Gln Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Pro37+Trp-Peptide N MS Val Val Tyr Pro Trp Thr Gln Arg Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Ser50+Thr-Peptide N MS Gly Asp Leu Ser Thr Pro Asp Ala Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Ala54+Val-Peptide N MS Thr Pro Asp Ala Val Met Gly Asn Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Val55+Met-Peptide N MS Pro Asp Ala Val Met Gly Asn Pro Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Asn58+Pro-Peptide N MS Val Met Gly Asn Pro Lys Val Lys Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Lys66+Lys-Peptide N MS Ala His Gly Lys Lys Val Leu Gly Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Ser73+Asp-Peptide N MS Gly Ala Phe Ser Asp Gly Leu Ala Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-His78+Leu-Peptide N MS Gly Leu Ala His Leu Asp Asn Leu Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Leu82+Lys-Peptide N MS Leu Asp Asn Leu Lys Gly Thr Phe Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Lys83+Gly-Peptide N MS Asp Asn Leu Lys Gly Thr Phe Ala Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Phe86+Ala-Peptide N MS Lys Gly Thr Phe Ala Thr Leu Ser Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Leu89+Ser-Peptide N MS Phe Ala Thr Leu Ser Glu Leu His Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Lys96+Leu-Peptide N MS His Cys Asp Lys Leu His Val Asp Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Asn109+Val-Peptide N MS Leu Leu Gly Asn Val Leu Val Cys Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-His118+Phe-Peptide N MS Leu Ala His His Phe Gly Lys Glu Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Phe123+Thr-Peptide N MS Gly Lys Glu Phe Thr Pro Pro Val Sripa et al., 2010
Hemoglobin subunit beta P68871 2-147 Peptide-Gln128+Ala-Peptide N MS Pro Pro Val Gln Ala Ala Tyr Gln Sripa et al., 2010
Peptide-Gly20-Ser-Peptide C7EXK1 16-337 Peptide-Gly20+Ser-Peptide P NT Glu Val Thr Gly Ser Ile Gly Met Sripa et al., 2010
Peptide-Thr94-Met-Peptide W5RUH3 1-308 Peptide-Thr94+Met-Peptide P MS Glu Asp Val Thr Met Asp Asn Ser Sripa et al., 2010
Tos-Gly-Pro-Arg-NHMec Tos-Gly-Pro-Arg+NHMec S Tos Gly Pro Arg AMC - - - Sripa et al., 2010
Tos-Gly-Pro-Lys-NHMec Tos-Gly-Pro-Lys+NHMec S Tos Gly Pro Lys AMC - - - Sripa et al., 2010
Z-Arg-Arg-NHMec Z-Arg-Arg+NHMec S - Z Arg Arg AMC - - - Dalton et al., 2004
Z-Arg-Arg-NHMec Z-Arg-Arg+NHMec S - Z Arg Arg AMC - - - Sripa et al., 2010
Z-Arg-Arg-NHPhNO2 Z-Arg-Arg+NHPhNO2 S - Z Arg Arg NAN - - - Kianifard et al., 2020
Z-Leu-Arg-NHMec Z-Leu-Arg+NHMec S - Z Leu Arg AMC - - - Sripa et al., 2010
Z-Phe-Arg-NHMec Z-Phe-Arg+NHMec S - Z Phe Arg AMC - - - Dalton et al., 2004
Z-Phe-Arg-NHMec Z-Phe-Arg+NHMec S - Z Phe Arg AMC - - - Sripa et al., 2010

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