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Literature for peptidase C01.062: cathepsin B-like peptidase (platyhelminth)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, K Knockout, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Holub,J., Jilkova,A., Lemke,C., Cianni,L., Spiwokova,P., Horn,M., Breuer,C., Leontovyc,A., Brynda,J., Mertlikova-Kaiserova,H., Chanova,M., Dos Reis Rocho,F., Montanari,C.A., El-Sakkary,N., Caffrey,C.R., Gutschow,M., Hnyk,D., Mares,M. and Fanfrlik,J.<br>Fat or flat? The impact of dipole moment vectors on non-covalent interactions between aromatic tags and macromolecules<br>Inorg Chem Front (2025) PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2024
  2. Fuchs,N., Zimmermann,R.A., Schwickert,M., Gunkel,A., Zimmer,C., Meta,M., Schwickert,K., Keiser,J., Haeberli,C., Kiefer,W. and Schirmeister,T.<br>Dual Strategy to Design New Agents Targeting Schistosoma mansoni: Advancing Phenotypic and SmCB1 Inhibitors for Improved Efficacy<br>ACS Infect Dis (2024) 10, 1664-1678. PubMed  Europe PubMed DOI  I
  3. Nascimento,I., Albino,S., Menezes,K., Cavalcanti,M., Oliveira,M., Mali,S. and Moura,R.<br>Targeting SmCB1: Perspectives and Insights to Design Antischistosomal Drugs<br>Curr Med Chem (2024) 31, 2264-2284. PubMed  Europe PubMed DOI
  4. Spiwokova,P., Horn,M., Fanfrlik,J., Jilkova,A., Fajtova,P., Leontovyc,A., Houstecka,R., Bielikova,L., Brynda,J., Chanova,M., Mertlikova-Kaiserova,H., Caro-Diaz,E.J.E., Almaliti,J., El-Sakkary,N., Gerwick,W.H., Caffrey,C.R. and Mares,M.<br>Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis<br>ACS Infect Dis (2024) 10, 1935-1948. PubMed  Europe PubMed DOI  I
    5. 2022
  5. Perera,D.J., Hassan,A.S., Liu,S.S., Elahi,S.M., Gadoury,C., Weeratna,R.D., Gilbert,R. and Ndao,M.<br>A low dose adenovirus vectored vaccine expressing Schistosoma mansoni Cathepsin B protects from intestinal schistosomiasis in mice<br>EBioMedicine (2022) 80, 104036-104036. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2020
  6. Dvorakova,H., Leontovyc,R., Machacek,T., O'Donoghue,A.J., Sedo,O., Zdrahal,Z., Craik,C.S., Caffrey,C.R., Horak,P. and Mikes,L.<br>Isoforms of cathepsin B1 in neurotropic schistosomula of Trichobilharzia regenti differ in substrate preferences and a highly expressed catalytically inactive paralog binds cystatin<br>Front Cell Infect Microbiol (2020) 10, 66-66. PubMed  Europe PubMed DOI  PMC  EPMC  P
  7. Jilkova,A., Horn,M. and Mares,M.<br>Structural and functional characterization of Schistosoma mansoni cathepsin B1<br>Methods Mol Biol (2020) 2151, 145-158. PubMed  Europe PubMed DOI  E  S  I
  8. Jilkova,A., Rubesova,P., Fanfrlik,J., Fajtova,P., Rezacova,P., Brynda,J., Lepsik,M., Mertlikova-Kaiserova,H., Emal,C.D., Renslo,A.R., Roush,W.R., Horn,M., Caffrey,C.R. and Mares,M.<br>Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors<br>ACS Infect Dis (2020) PubMed  Europe PubMed DOI
  9. Jilkova,A., Horn,M., Fanfrlik,J., Kuppers,J., Pachl,P., Rezacova,P., Lepsik,M., Fajtova,P., Rubesova,P., Chanova,M., Caffrey,C.R., Gutschow,M. and Mares,M.<br>Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity<br>ACS Infect Dis (2020) PubMed  Europe PubMed DOI
  10. Kianifard,L., Yakhchali,M. and Imani,M.<br>The Effects of pH and Temperature on Cysteine Protease (Cathepsin B) Activity in Miracidia and Eggs of Fasciola hepatica<br>Iran J Parasitol (2020) 15, 233-239. PubMed  Europe PubMed  PMC  EPMC
  11. Perera,D.J., Hassan,A.S., Jia,Y., Ricciardi,A., McCluskie,M.J., Weeratna,R.D. and Ndao,M.<br>Adjuvanted Schistosoma mansoni-Cathepsin B With Sulfated Lactosyl Archaeol Archaeosomes or AddaVax Provides Protection in a Pre-Clinical Schistosomiasis Model<br>Front Immunol (2020) 11, 605288-605288. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Tallima,H., Abou El Dahab,M. and El Ridi,R.<br>Specific Antibodies and Arachidonic Acid Mediate the Protection Induced by the Schistosoma mansoni Cysteine Peptidase-Based Vaccine in Mice<br>Vaccines (Basel) (2020) 8 PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2019
  13. Soloviova,K., Fox,E.C., Dalton,J.P., Caffrey,C.R. and Davies,S.J.<br>A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response<br>PLoS Negl Trop Dis (2019) 13, e0007070-e0007070. PubMed  Europe PubMed DOI
    14. 2015
  14. Chen,W., Ning,D., Wang,X., Chen,T., Lv,X., Sun,J., Wu,D., Huang,Y., Xu,J. and Yu,X.<br>Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis<br>Parasit Vectors (2015) 8, 647-647. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Fonseca,N.C., da Cruz,L.F., da Silva Villela,F., do Nascimento Pereira,G.A., de Siqueira-Neto,J.L., Kellar,D., Suzuki,B.M., Ray,D., de Souza,T.B., Alves,R.J., Junior,P.A., Romanha,A.J., Murta,S.M., McKerrow,J.H., Caffrey,C.R., de Oliveira,R.B. and Ferreira,R.S.<br>Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1<br>Antimicrob Agents Chemother (2015) 59, 2666-2677. PubMed  Europe PubMed DOI  I
  16. Ricciardi,A., Dalton,J.P. and Ndao,M.<br>Evaluation of the immune response and protective efficacy of Schistosoma mansoni cathepsin B in mice using CpG dinucleotides as adjuvant<br>Vaccine (2015) 33, 346-353. PubMed  Europe PubMed DOI
  17. Siricoon,S., Vichasri Grams,S., Lertwongvisarn,K., Abdullohfakeeyah,M., Smooker,P.M. and Grams,R.<br>Fasciola gigantica cathepsin B5 is an acidic endo- and exopeptidase of the immature and mature parasite<br>Biochimie (2015) 119, 6-15. PubMed  Europe PubMed DOI
    18. 2014
  18. Chen,W., Wang,X., Lv,X., Tian,Y., Xu,Y., Mao,Q., Shang,M., Li,X., Huang,Y. and Yu,X.<br>Characterization of the secreted cathepsin B cysteine proteases family of the carcinogenic liver fluke Clonorchis sinensis<br>Parasitol Res (2014) 113, 3409-3418. PubMed  Europe PubMed DOI
  19. Dalton,J.P. and Dvorak,J.<br>Activating the cathepsin B1 of a parasite: a major route with alternative pathways?<br>Structure (2014) 22, 1696-1698. PubMed  Europe PubMed DOI  S
  20. El Ridi,R., Tallima,H., Dalton,J.P. and Donnelly,S.<br>Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases<br>Front Genet (2014) 5, 119-119. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Jilkova,A., Horn,M., Rezacova,P., Maresova,L., Fajtova,P., Brynda,J., Vondrasek,J., McKerrow,J.H., Caffrey,C.R. and Mares,M.<br>Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch<br>Structure (2014) 22, 1786-1798. PubMed  Europe PubMed DOI  S
    22. 2013
  22. Fanfrlik,J., Brahmkshatriya,P.S., Rezac,J., Jilkova,A., Horn,M., Mares,M., Hobza,P. and Lepsik,M.<br>Quantum mechanics-based scoring rationalizes the irreversible inactivation of parasitic Schistosoma mansoni cysteine peptidase by vinyl sulfone inhibitors<br>J Phys Chem B (2013) 117, 14973-14982. PubMed  Europe PubMed DOI  I
    23. 2012
  23. Robinson,M.W., Brindley,P.J., McKerrow,J.H. and Dalton,J.P.<br>Trematode cysteine endopeptidases<br>[ISSN:978-0-12-407743-0] (2012) 3, 1941-1949. DOI
  24. Sripa,J., Brindley,P.J., Sripa,B., Loukas,A., Kaewkes,S. and Laha,T.<br>Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorchiasis<br>Parasitol Int (2012) 61, 191-195. PubMed  Europe PubMed DOI
    25. 2011
  25. Horn,M., Jilkova,A., Vondrasek,J., Maresova,L., Caffrey,C.R. and Mares,M.<br>Mapping the pro-peptide of the Schistosoma mansoni cathepsin B1 drug target: modulation of inhibition by heparin and design of mimetic inhibitors<br>ACS Chem Biol (2011) 6, 609-617. PubMed  Europe PubMed DOI
  26. Kasny,M., Mikes,L., Doleckova,K., Hampl,V., Dvorak,J., Novotny,M. and Horak,P.<br>Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis<br>Adv Exp Med Biol (2011) 712, 136-154. PubMed  Europe PubMed DOI
  27. Sripa,J., Pinlaor,P., Brindley,P.J., Sripa,B., Kaewkes,S., Robinson,M.W., Young,N.D., Gasser,R.B., Loukas,A. and Laha,T.<br>RNA interference targeting cathepsin B of the carcinogenic liver fluke, Opisthorchis viverrini<br>Parasitol Int (2011) 60, 283-288. PubMed  Europe PubMed DOI  K
    28. 2010
  28. Donnelly,S., O'Neill,S.M., Stack,C.M., Robinson,M.W., Turnbull,L., Whitchurch,C. and Dalton,J.P.<br>Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3<br>J Biol Chem (2010) 285, 3383-3392. PubMed  Europe PubMed DOI
  29. Sripa,J., Laha,T., To,J., Brindley,P.J., Sripa,B., Kaewkes,S., Dalton,J.P. and Robinson,M.W.<br>Secreted cysteine proteases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans-processing by cathepsin B<br>Cell Microbiol (2010) 12, 781-795. PubMed  Europe PubMed DOI
  30. Tchoubrieva,E.B., Ong,P.C., Pike,R.N., Brindley,P.J. and Kalinna,B.H.<br>Vector-based RNA interference of cathepsin B1 in Schistosoma mansoni<br>Cell Mol Life Sci (2010) 67, 3739-3748. PubMed  Europe PubMed DOI  K
    31. 2009
  31. Doleckova,K., Kasny,M., Mikes,L., Cartwright,J., Jedelsky,P., Schneider,E.L., Dvorak,J., Mountford,A.P., Craik,C.S. and Horak,P.<br>The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti<br>Int J Parasitol (2009) 39, 201-211. PubMed  Europe PubMed DOI  PMC  EPMC
    32. 2008
  32. Kaewpitoon,N., Laha,T., Kaewkes,S., Yongvanit,P., Brindley,P.J., Loukas,A. and Sripa,B.<br>Characterization of cysteine proteases from the carcinogenic liver fluke, Opisthorchis viverrini<br>Parasitol Res (2008) 102, 757-764. PubMed  Europe PubMed DOI
  33. Krautz-Peterson,G. and Skelly,P.J.<br>Schistosome asparaginyl endopeptidase (legumain) is not essential for cathepsin B1 activation in vivo<br>Mol Biochem Parasitol (2008) 159, 54-58. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2006
  34. [YEAR:6-3-2006]Choe,Y., Leonetti,F., Greenbaum,D.C., Lecaille,F., Bogyo,M., Bromme,D., Ellman,J.A. and Craik,C.S.<br>Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities<br>J Biol Chem (6-3-2006) 281, 12824-12832. PubMed  Europe PubMed DOI  P
    35. 2005
  35. [YEAR:30-7-2005]Correnti,J.M., Brindley,P.J. and Pearce,E.J.<br>Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth<br>Mol Biochem Parasitol (30-7-2005) 143, 209-215. PubMed  Europe PubMed DOI
  36. [YEAR:8-6-2005]Dvorak,J., Delcroix,M., Rossi,A., Vopalensky,V., Pospisek,M., Sedinova,M., Mikes,L., Sajid,M., Sali,A., McKerrow,J.H., Horak,P. and Caffrey,C.R.<br>Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition<br>Int J Parasitol (8-6-2005) 35, 895-910. PubMed  Europe PubMed DOI
  37. Stack,C.M., Dalton,J.P., Cunneen,M. and Donnelly,S.<br>De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serum<br>J Immunol Methods (2005) 304, 151-157. PubMed  Europe PubMed DOI
    38. 2004
  38. Dalton,J.P., McKerrow,J.H. and Brindley,P.J.<br>Trematode cysteine endopeptidases<br>[ISSN:0-12-079610-4] (2004) 2, 1176-1182.  V
    39. 2003
  39. Sajid,M., McKerrow,J.H., Hansell,E., Mathieu,M.A., Lucas,K.D., Hsieh,I., Greenbaum,D., Bogyo,M., Salter,J.P., Lim,K.C., Franklin,C., Kim,J.H. and Caffrey,C.R.<br>Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase<br>Mol Biochem Parasitol (2003) 131, 65-75. PubMed  Europe PubMed DOI
    40. 2002
  40. Sajid,M. and McKerrow,J.H.<br>Cysteine proteases of parasitic organisms<br>Mol Biochem Parasitol (2002) 120, 1-21. PubMed  Europe PubMed
    41. 2001
  41. Noya,O., De Noya,B.A., Ballen,D.E., Bermudez,H., Bout,D. and Hoebeke,J.<br>Immunogenicity of synthetic peptides from the Sm31 antigen (cathepsin B) of the Schistosoma mansoni adult worms<br>Parasite Immunol (2001) 23, 567-573. PubMed  Europe PubMed DOI
  42. Skelly,P.J. and Shoemaker,C.B.<br>Schistosoma mansoni proteases Sm31 (cathepsin B) and Sm32 (legumain) are expressed in the cecum and protonephridia of cercariae<br>J Parasitol (2001) 87, 1218-1221. PubMed  Europe PubMed DOI
    43. 1998
  43. Choi,M.H., Chai,J.Y. and Lee,S.H.<br>Purification and characterization of a 16-kDa cysteine proteinase of Gymnophalloides seoi (Gymnophallidae) metacercariae<br>J Parasitol (1998) 84, 350-355. PubMed  Europe PubMed DOI
  44. El-Sayed,L.H., Ghoneim,H., Demian,S.R., El-Sayed,M.H., Tawfik,N.M., Sakr,I., Abou-Basha,L.M., Renganathan,E., Klinkert,M.Q. and Abou-Rawash,N.<br>Diagnostic significance of Schistosoma mansoni proteins Sm31 and Sm32 in human schistosomiasis in an endemic area in Egypt<br>Trop Med Int Health (1998) 3, 721-727. PubMed  Europe PubMed DOI
    45. 1997
  45. Caffrey,C.R., Rheinberg,C.E., Mone,H., Jourdane,J., Li,Y.L. and Ruppel,A.<br>Schistosoma japonicum, S. mansoni, S. haematobium, S. intercalatum, and S. rodhaini: cysteine-class cathepsin activities in the vomitus of adult worms<br>Parasitol Res (1997) 83, 37-41. PubMed  Europe PubMed
  46. Caffrey,C.R. and Ruppel,A.<br>Cathepsin B-like activity predominates over cathepsin L-like activity in adult Schistosoma mansoni and S. japonicum<br>Parasitol Res (1997) 83, 632-635. PubMed  Europe PubMed DOI
  47. Dalton,J.P., Clough,K.A., Jones,M.K. and Brindley,P.J.<br>The cysteine proteinases of Schistosoma mansoni cercariae<br>Parasitology (1997) 114, 105-112. PubMed  Europe PubMed DOI
  48. Grogan,J., Rotmans,P., Ghoneim,H., Deelder,A., Yazdanbakhsh,M. and Klinkert,M.Q.<br>Recognition of Schistosoma mansoni cathepsins B and L by human IgG1 and IgG4 antibodies<br>Parasite Immunol (1997) 19, 215-220. PubMed  Europe PubMed
    49. 1996
  49. Dalton,J.P., Clough,K.A., Jones,M.K. and Brindley,P.J.<br>Characterization of the cathepsin-like cysteine proteinases of Schistosoma mansoni<br>Infect Immun (1996) 64, 1328-1334. PubMed  Europe PubMed  PMC  EPMC
  50. Li,Y.L., Idris,M.A., Corachan,M., Han,J.J., Kirschfink,M. and Ruppel,A.<br>Circulating antigens in schistosomiasis: detection of 31/32-kDa proteins in sera from patients infected with Schistosoma japonicum, S. mansoni, S. haematobium, or S. intercalatum<br>Parasitol Res (1996) 82, 14-18. PubMed  Europe PubMed DOI
  51. Lipps,G., Fullkrug,R. and Beck,E.<br>Cathepsin B of Schistosoma mansoni. Purification and activation of the recombinant proenzyme secreted by Saccharomyces cerevisiae<br>J Biol Chem (1996) 271, 1717-1725. PubMed  Europe PubMed
    52. 1995
  52. Ghoneim,H. and Klinkert,M.Q.<br>Biochemical properties of purified cathepsin B from Schistosoma mansoni<br>Int J Parasitol (1995) 25, 1515-1519. PubMed  Europe PubMed DOI
    53. 1993
  53. Yamasaki,H. and Aoki,T.<br>Cloning and sequence analysis of the major cysteine protease expressed in the trematode parasite Fasciola sp<br>Biochem Mol Biol Int (1993) 31, 537-542. PubMed  Europe PubMed
  54. Yoshino,T.P., Lodes,M.J., Rege,A.A. and Chappell,C.L.<br>Proteinase activity in miracidia, transformation excretory-secretory products, and primary sporocysts of Schistosoma mansoni<br>J Parasitol (1993) 79, 23-31. PubMed  Europe PubMed
    55. 1992
  55. Gotz,B., Felleisen,R., Shaw,E. and Klinkert,M.Q.<br>Expression of an active cathepsin B-like protein Sm31 from Schistosoma mansoni in insect cells<br>Trop Med Parasitol (1992) 43, 282-284. PubMed  Europe PubMed
    56. 1989
  56. Klinkert,M.Q., Felleisen,R., Link,G., Ruppel,A. and Beck,E.<br>Primary structures of Sm31/32 diagnostic proteins of Schistosoma mansoni and their identification as proteases<br>Mol Biochem Parasitol (1989) 33, 113-122. PubMed  Europe PubMed
    57. 1988
  57. Zerda,K.S., Dresden,M.H. and Chappell,C.L.<br>Schistosoma mansoni: expression and role of cysteine proteinases in developing schistosomula<br>Exp Parasitol (1988) 67, 238-246. PubMed  Europe PubMed
    58. 1987
  58. Ruppel,A., Shi,Y.E., Wei,D.X. and Diesfeld,H.J.<br>Sera of Schistosoma japonicum-infected patients cross-react with diagnostic 31/32 kD proteins of S. mansoni<br>Clin Exp Immunol (1987) 69, 291-298. PubMed  Europe PubMed  PMC  EPMC
    59. 1986
  59. Sung,C.K. and Dresden,M.H.<br>Cysteinyl proteinases of Schistosoma mansoni eggs: purification and partial characterization<br>J Parasitol (1986) 72, 891-900. PubMed  Europe PubMed
    60. 1979
  60. Asch,H.L. and Dresden,M.H.<br>Acidic thiol proteinase activity of Schistosoma mansoni egg extracts<br>J Parasitol (1979) 65, 543-549. PubMed  Europe PubMed

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