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Substrates for peptidase C01.013: cathepsin X

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Abz-Phe-Arg-NPh-OH Abz-Phe-Arg+NPh-OH S - Abz Phe Arg Nph - - - Menard & Sulea, 2004
Abz-Phe-Glu-Lys(Dnp)-OH Abz-Phe-Glu+Lys(Dnp)-OH S - Abz Phe Glu Lyd - - - Jevnikar et al., 2009
alpha-enolase P06733 420-434 Lys-Ala-Lys-Phe-Ala-Gly-Arg-Asn-Phe-Arg-Asn-Pro-Leu-Ala+Lys P MS Asn Pro Leu Ala Lys - - - Obermajer et al., 2009
alpha-enolase P06733 420-433 Lys-Ala-Lys-Phe-Ala-Gly-Arg-Asn-Phe-Arg-Asn-Pro-Leu+Ala P MS Arg Asn Pro Leu Ala - - - Obermajer et al., 2009
Bz-Arg-NH2 Bz-Arg+NH2 S - - Bz Arg NH2 - - - Barrett, 1998
Bz-Gly-Arg Bz-Gly+Arg S - - Bz Gly Arg - - - Barrett, 1998
consensus aminoacyl-Pro bond peptide+Pro N - - - NPe Pro - - - Menard & Sulea, 2004
CXCL12 protein Q6ICW0 1-89 peptide-Asn88+Lys P MS Lys Ala Leu Asn Lys - - - Staudt et al., 2010
CXCL12 protein Q6ICW0 1-88 peptide-Leu87+Asn P MS Glu Lys Ala Leu Asn - - - Staudt et al., 2010
CXCL12 protein Q6ICW0 1-87 peptide-Ala86+Ala P MS Leu Glu Lys Ala Leu - - - Staudt et al., 2010
CXCL12 protein Q6ICW0 1-86 peptide-Lys85+Ala P MS Tyr Leu Glu Lys Ala - - - Staudt et al., 2010
CXCL12 protein Q6ICW0 1-85 peptide-Glu84+Lys P MS Glu Tyr Leu Glu Lys - - - Staudt et al., 2010
CXCL12 protein Q6ICW0 1-84 peptide-Leu83+Glu P MS Gln Glu Tyr Leu Glu - - - Staudt et al., 2010
CXCL12 protein Q6ICW0 1-83 peptide-Tyr82+Tyr P MS Ile Gln Glu Tyr Leu - - - Staudt et al., 2010
CXCL12 protein Q6ICW0 1-82 peptide-Glu81+Tyr P MS Trp Ile Gln Glu Tyr - - - Staudt et al., 2010
CXCL12 protein Q6ICW0 1-81 peptide-Gln80+Glu P MS Lys Trp Ile Gln Glu - - - Staudt et al., 2010
CXCL12 protein Q6ICW0 1-80 peptide-Ile79+Gln P MS Leu Lys Trp Ile Gln - - - Staudt et al., 2010
CXCL12 protein Q6ICW0 1-79 peptide-Trp78+Ile P MS Lys Leu Lys Trp Ile - - - Staudt et al., 2010
CXCL12 protein Q6ICW0 1-78 peptide-Lys77+Trp P MS Pro Lys Leu Lys Trp - - - Staudt et al., 2010
CXCL12 protein Q6ICW0 1-77 peptide-Leu76+Lys P MS Asp Pro Lys Leu Lys - - - Staudt et al., 2010
CXCL12 protein Q6ICW0 1-76 peptide-Lys75+Lys P MS Ile Asp Pro Lys Leu - - - Staudt et al., 2010
gamma-enolase P09104 405-434 peptide-Val433+Val P MS Asn Pro Ser Val Leu - - - Obermajer et al., 2009
gamma-enolase P09104 405-433 peptide-Ser432+Val P MS Arg Asn Pro Ser Val - - - Obermajer et al., 2009
ITGB2 integrin, beta 2 precursor P05107 724-766 peptide-Lys765+Phe P Met Asn Pro Lys Phe - - - Obermajer et al., 2008 21547
ITGB2 integrin, beta 2 precursor P05107 724-767 peptide-Phe766+Ala P Asn Pro Lys Phe Ala - - - Obermajer et al., 2008 21548
ITGB2 integrin, beta 2 precursor P05107 724-768 peptide-Ala767+Glu P Pro Lys Phe Ala Glu - - - Obermajer et al., 2008 21549
ITGB2 integrin, beta 2 precursor P05107 724-769 peptide-Glu768+Ser P Lys Phe Ala Glu Ser - - - Obermajer et al., 2008 21550
Leu-Trp-Met Leu-Trp+Met N - - Leu Trp Met - - - Barrett, 1998
Leu-Trp-Met-Arg Leu-Trp-Met+Arg N - Leu Trp Met Arg - - - Barrett, 1998
Leu-Trp-Met-Arg-Phe Leu-Trp-Met-Arg+Phe N Leu Trp Met Arg Phe - - - Barrett, 1998
Leu-Trp-Met-Arg-Phe-Ala Leu-Trp-Met-Arg-Phe+Ala N Trp Met Arg Phe Ala - - - Barrett, 1998
stromal cell-derived factor 1 P48061 24-89 peptide-Asn88+Lys P MS Lys Ala Leu Asn Lys - - - Staudt et al., 2010
stromal cell-derived factor 1 P48061 24-88 peptide-Leu87+Asn P MS Glu Lys Ala Leu Asn - - - Staudt et al., 2010
stromal cell-derived factor 1 P48061 24-87 peptide-Ala86+Ala P MS Leu Glu Lys Ala Leu - - - Staudt et al., 2010
Val-Leu-Ser Val-Leu+Ser N - - Val Leu Ser - - - Barrett, 1998
Val-Leu-Ser-Glu Val-Leu-Ser+Glu N - Val Leu Ser Glu - - - Barrett, 1998
Val-Leu-Ser-Glu-Gly Val-Leu-Ser-Glu+Gly N Val Leu Ser Glu Gly - - - Barrett, 1998
Z-Glu-Tyr Z-Glu+Tyr S - - Z Glu Tyr - - - Barrett, 1998
Z-Gly-Arg Z-Gly+Arg S - - Z Gly Arg - - - Barrett, 1998
Z-Gly-Asp Z-Gly+Asp S - - Z Gly Asp - - - Barrett, 1998
Z-Gly-Gly Z-Gly+Gly S - - Z Gly Gly - - - Barrett, 1998
Z-Gly-Leu Z-Gly+Leu S - - Z Gly Leu - - - Barrett, 1998
Z-Gly-Met Z-Gly+Met S - - Z Gly Met - - - Barrett, 1998
Z-Gly-Phe Z-Gly+Phe S - - Z Gly Phe - - - Barrett, 1998
Z-Gly-Ser Z-Gly+Ser S - - Z Gly Ser - - - Barrett, 1998
Z-Phe-Arg-NHMec Z-Phe-Arg+NHMec S - Z Phe Arg AMC - - - Menard & Sulea, 2004

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