Literature for peptidase C01.013: cathepsin X

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Horvat,S., Pecar Fonovic,U., Zidar,N., Doljak,B., Kos,J. and Pislar,A. Neuronal Subtype-Specific Expression of gamma-Enolase: Its Role in Neuronal Differentiation Neuromolecular Med (2026) 28, 4-4. PubMed Europe PubMed DOI PMC EPMC

2025

Horvat,S., Zidar,N., Kos,J. and Pislar,A. alpha-Enolase and gamma-Enolase Expression in Enriched S- and N-Type SH-SY5Y Cells: Regulatory Role of Cathepsin X Mol Neurobiol (2025) PubMed Europe PubMed DOI
Meade,R.K., Adefisayo,O.O., Gontijo,M.T.P., Harris,S.J., Pyle,C.J., Wilburn,K.M., Ecker,A.M.V., Hughes,E.J., Garcia,P.D., Ivie,J., McHenry,M.L., Benchek,P.H., Mayanja-Kizza,H., Neff,J.L., Ko,D.C., Stout,J.E., Stein,C.M., Hawn,T.R., Tobin,D.M. and Smith,C.M. Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC
Mizrachi,A., Sadeh,M., Ben-Dor,S., Dym,O., Ku,C., Feldmesser,E., Zarfin,A., Brunson,J.K., Allen,A.E., Jinkerson,R.E., Schatz,D. and Vardi,A. Cathepsin X is a conserved cell death protein involved in algal response to environmental stress Curr Biol (2025) PubMed Europe PubMed DOI
Tao,J., Chen,Y., Bian,X., Cai,T., Song,C., Liang,C., Hao,Z., Meng,J., Ge,Q. and Zhou,J. Prognostic and immunological implications of cathepsin Z overexpression in prostate cancer Front Immunol (2025) 16, 1618487-1618487. PubMed Europe PubMed DOI PMC EPMC K

2024

Deng,T., Lu,X., Jia,X., Du,J., Wang,L., Cao,B., Yang,M., Yin,Y. and Liu,F. Cathepsins and cancer risk: a Mendelian randomization study Front Endocrinol (Lausanne) (2024) 15, 1428433-1428433. PubMed Europe PubMed DOI PMC EPMC
Gallwitz,L., Bleibaum,F., Voss,M., Schweizer,M., Spengler,K., Winter,D., Zophel,F., Muller,S., Lichtenthaler,S., Damme,M. and Saftig,P. Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis Cell Mol Life Sci (2024) 81, 227-227. PubMed Europe PubMed DOI PMC EPMC
Xu,B., Anderson,B.M., Mountford,S.J., Thompson,P.E., Mintern,J.D. and Edgington-Mitchell,L.E. Cathepsin X deficiency alters the processing and localisation of cathepsin L and impairs cleavage of a nuclear cathepsin L substrate Biol Chem (2024) 405, 351-365. PubMed Europe PubMed DOI
Xu,B., Mountford,S.J., Thompson,P.E. and Edgington-Mitchell,L.E. Expanding the Library of Covalent Cysteine Cathepsin Probes Featuring Sulfoxonium Ylide Electrophiles ACS Omega (2024) 9, 43940-43947. PubMed Europe PubMed DOI PMC EPMC

2023

Malovitski,K., Sarig,O., Feller,Y., Bergson,S., Assaf,S., Mohamad,J., Pavlovsky,M., Giladi,M. and Sprecher,E. Defective cathepsin Z affects EGFR expression and causes autosomal dominant palmoplantar keratoderma Br J Dermatol (2023) 189, 302-311. PubMed Europe PubMed DOI
Stoka,V., Vasiljeva,O., Nakanishi,H. and Turk,V. The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC V

2020

Dolenc,I., Stefe,I., Turk,D., Taler-Vercic,A., Turk,B., Turk,V. and Stoka,V. Human cathepsin X/Z is a biologically active homodimer Biochim Biophys Acta Proteins Proteom (2020) 1869, 140567-140567. PubMed Europe PubMed DOI
Fonovic,U.P., Knez,D., Hrast,M., Zidar,N., Proj,M., Gobec,S. and Kos,J. Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X Eur J Med Chem (2020) 193, 112218-112218. PubMed Europe PubMed DOI I
Mountford,S.J., Anderson,B.M., Xu,B., Tay,E.S.V., Szabo,M., Hoang,M.L., Diao,J., Aurelio,L., Campden,R.I., Lindstrom,E., Sloan,E.K., Yates,R.M., Bunnett,N.W., Thompson,P.E. and Edgington-Mitchell,L.E. Application of a sulfoxonium ylide electrophile to generate cathepsin X-selective activity-based probes ACS Chem Biol (2020) 15, 718-727. PubMed Europe PubMed DOI I
Pislar,A., Tratnjek,L., Glavan,G., Zidar,N., Zivin,M. and Kos,J. Neuroinflammation-Induced Upregulation of Glial Cathepsin X Expression and Activity in vivo Front Mol Neurosci (2020) 13, 575453-575453. PubMed Europe PubMed DOI PMC EPMC
Shen,Y., Su,Y., Silva,F.J., Weller,A.H., Sostre-Colon,J., Titchenell,P.M., Steger,D.J., Seale,P. and Soccio,R.E. Shared PPARalpha/gamma target genes regulate brown adipocyte thermogenic function Cell Rep (2020) 30, 3079-3091. PubMed Europe PubMed DOI

2019

Cai,X., Gao,C., Song,H., Yang,N., Fu,Q., Tan,F. and Li,C. Characterization, expression profiling and functional characterization of cathepsin Z (CTSZ) in turbot (Scophthalmus maximus L.) Fish Shellfish Immunol (2019) 84, 599-608. PubMed Europe PubMed DOI
Choi,K.M., Joo,M.S., Cho,D.H., Han,H.J., Kim,M.S., Cho,M.Y., Jung,S.H., Kim,D.H. and Park,C.I. Functional analysis and gene expression profiling of extracellular cathepsin Z in red sea bream, Pagrus major Fish Shellfish Immunol (2019) 93, 208-215. PubMed Europe PubMed DOI E
Dera,A.A., Ranganath,L., Barraclough,R., Vinjamuri,S., Hamill,S. and Barraclough,D.L. Cathepsin Z as a novel potential biomarker for osteoporosis Sci Rep (2019) 9, 9752-9752. PubMed Europe PubMed DOI PMC EPMC
Lewis,M.S., Danelishvili,L., Rose,S.J. and Bermudez,L.E. MAV_4644 Interaction with the host cathepsin Z protects Mycobacterium avium subsp. hominissuis from rapid macrophage killing Microorganisms (2019) 7 PubMed Europe PubMed DOI
Schwenck,J., Maurer,A., Fehrenbacher,B., Mehling,R., Knopf,P., Mucha,N., Haupt,D., Fuchs,K., Griessinger,C.M., Bukala,D., Holstein,J., Schaller,M., Menendez,I.G., Ghoreschi,K., Quintanilla-Martinez,L., Gutschow,M., Laufer,S., Reinheckel,T., Rocken,M., Kalbacher,H., Pichler,B.J. and Kneilling,M. Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions Theranostics (2019) 9, 3903-3917. PubMed Europe PubMed DOI PMC EPMC K

2018

Pislar,A., Tratnjek,L., Glavan,G., Zivin,M. and Kos,J. Upregulation of cysteine protease cathepsin X in the 6-hydroxydopamine model of Parkinson's disease Front Mol Neurosci (2018) 11, 412-412. PubMed Europe PubMed DOI PMC EPMC

2017

Allan,E.R.O., Campden,R.I., Ewanchuk,B.W., Tailor,P., Balce,D.R., McKenna,N.T., Greene,C.J., Warren,A.L., Reinheckel,T. and Yates,R.M. A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis J Neuroinflammation (2017) 14, 103-103. PubMed Europe PubMed DOI PMC EPMC K
Fonovic,U.P., Mitrovic,A., Knez,D., Jakos,T., Pislar,A., Brus,B., Doljak,B., Stojan,J., Zakelj,S., Trontelj,J., Gobec,S. and Kos,J. Identification and characterization of the novel reversible and selective cathepsin X inhibitors Sci Rep (2017) 7, 11459-11459. PubMed Europe PubMed DOI PMC EPMC I
Godahewa,G.I., Perera,N.C.N., Lee,S., Kim,M.J. and Lee,J. A cysteine protease (cathepsin Z) from disk abalone, Haliotis discus discus: genomic characterization and transcriptional profiling during bacterial infections Gene (2017) 627, 500-507. PubMed Europe PubMed DOI
Orlowski,G.M., Sharma,S., Colbert,J.D., Bogyo,M., Robertson,S.A., Kataoka,H., Chan,F.K. and Rock,K.L. Frontline science: multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1beta activation J Leukoc Biol (2017) 102, 7-17. PubMed Europe PubMed DOI
Pislar,A., Bozic,B., Zidar,N. and Kos,J. Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation Neuropharmacology (2017) 114, 88-100. PubMed Europe PubMed DOI I

2016

Akkari,L., Gocheva,V., Quick,M.L., Kester,J.C., Spencer,A.K., Garfall,A.L., Bowman,R.L. and Joyce,J.A. Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer Genes Dev (2016) 30, 220-232. PubMed Europe PubMed DOI PMC EPMC K

2015

Kos,J., Vizin,T., Fonovic,U.P. and Pislar,A. Intracellular signaling by cathepsin X: molecular mechanisms and diagnostic and therapeutic opportunities in cancer Semin Cancer Biol (2015) 31, 76-83. PubMed Europe PubMed DOI
Pecar Fonovic,U. and Kos,J. Cathepsin X cleaves profilin 1 C-terminal Tyr139 and influences clathrin-mediated endocytosis PLoS ONE (2015) 10, e0137217-e0137217. PubMed Europe PubMed DOI
Pohl,S. and Hasilik,A. Biosynthesis, targeting, and processing of lysosomal proteins: Pulse-chase labeling and immune precipitation Methods Cell Biol (2015) 126, 63-83. PubMed Europe PubMed DOI
Teller,A., Jechorek,D., Hartig,R., Adolf,D., Reissig,K., Roessner,A. and Franke,S. Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer Pathol Res Pract (2015) 211, 62-70. PubMed Europe PubMed DOI

2014

Akkari,L., Gocheva,V., Kester,J.C., Hunter,K.E., Quick,M.L., Sevenich,L., Wang,H.W., Peters,C., Tang,L.H., Klimstra,D.S., Reinheckel,T. and Joyce,J.A. Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix Genes Dev (2014) 28, 2134-2150. PubMed Europe PubMed DOI PMC EPMC

2013

Bak,H.J., Kim,M.S., Kim,N.Y., Go,H.J., Han,J.W., In Jo,H., Ahn,S.J., Park,N.G., Chung,J.K. and Lee,H.H. Molecular cloning, expression, and enzymatic analysis of cathepsin X from starfish (Asterina pectinifera) Appl Biochem Biotechnol (2013) 169, 847-861. PubMed Europe PubMed DOI
Buhler,A., Berger,S., Bengsch,F., Martin,G., Han,H., Vierkotten,S., Pielen,A., Boehringer,D., Schlunck,G., Fauser,S., Agostini,H.T., Reinheckel,T. and Stahl,A. Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice Exp Eye Res (2013) 115, 73-78. PubMed Europe PubMed DOI K
Hafner,A., Glavan,G., Obermajer,N., Zivin,M., Schliebs,R. and Kos,J. Neuroprotective role of gamma-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X Aging Cell (2013) 12, 604-614. PubMed Europe PubMed DOI
Pecar Fonovic,U., Jevnikar,Z., Rojnik,M., Doljak,B., Fonovic,M., Jamnik,P. and Kos,J. Profilin 1 as a target for cathepsin X activity in tumor cells PLoS ONE (2013) 8, e53918-e53918. PubMed Europe PubMed DOI PMC EPMC I
Serrano-Luna,J., Pina-Vazquez,C., Reyes-Lopez,M., Ortiz-Estrada,G. and de la Garza,M. Proteases from Entamoeba spp. and pathogenic free-living amoebae as virulence factors J Trop Med (2013) 2013, 890603-890603. PubMed Europe PubMed DOI PMC EPMC V
Skvarc,M., Stubljar,D., Kopitar,A.N., Jeverica,S., Tepes,B., Kos,J. and Ihan,A. Inhibition of cathepsin X enzyme influences the immune response of THP-1 cells and dendritic cells infected with Helicobacter pylori Radiol Oncol (2013) 47, 258-265. PubMed Europe PubMed DOI PMC EPMC I

2012

Kraus,S., Fruth,M., Bunsen,T. and Nagler,D.K. IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells Biol Chem (2012) 393, 1457-1462. PubMed Europe PubMed DOI K
Lines,K.E., Chelala,C., Dmitrovic,B., Wijesuriya,N., Kocher,H.M., Marshall,J.F. and Crnogorac-Jurcevic,T. S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells Am J Pathol (2012) 180, 1485-1494. PubMed Europe PubMed DOI
Nagler,D.K., Menard,R. and Sulea,T. Cathepsin X [ISSN:978-0-12-407743-0] (2012) 3, 1839-1844. DOI

2011

Adams,L.A., Moller,M., Nebel,A., Schreiber,S., vanderMerwe,L., vanHelden,P.D. and Hoal,E.G. Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility Eur J Hum Genet (2011) 19, 676-681. PubMed Europe PubMed DOI
Baker,A.R., Zalwango,S., Malone,L.L., Igo,R.P., Jr., Qiu,F., Nsereko,M., Adams,M.D., Supelak,P., Mayanja-Kizza,H., Boom,W.H. and Stein,C.M. Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study Hum Immunol (2011) 72, 426-430. PubMed Europe PubMed DOI M
Jevnikar,Z., Obermajer,N., Doljak,B., Turk,S., Gobec,S., Svajger,U., Hailfinger,S., Thome,M. and Kos,J. Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells J Leukoc Biol (2011) 90, 99-109. PubMed Europe PubMed DOI
Jevnikar,Z., Obermajer,N. and Kos,J. LFA-1 fine-tuning by cathepsin X IUBMB Life (2011) 63, 686-693. PubMed Europe PubMed DOI
Kraus,S., Bunsen,T., Schuster,S., Cichon,M.A., Tacke,M., Reinheckel,T., Sommerhoff,C.P., Jochum,M. and Nagler,D.K. Cellular senescence induced by cathepsin X downregulation Eur J Cell Biol (2011) 90, 678-686. PubMed Europe PubMed DOI K
Paulick,M.G. and Bogyo,M. Development of activity-based probes for cathepsin X ACS Chem Biol (2011) 6, 563-572. PubMed Europe PubMed DOI
Ratovitski,T., Chighladze,E., Waldron,E., Hirschhorn,R.R. and Ross,C.A. Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin J Biol Chem (2011) 286, 12578-12589. PubMed Europe PubMed DOI
Wang,J., Chen,L., Li,Y. and Guan,X.Y. Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma PLoS ONE (2011) 6, e24967-e24967. PubMed Europe PubMed DOI PMC EPMC

2010

Bernhardt,A., Kuester,D., Roessner,A., Reinheckel,T. and Krueger,S. Cathepsin X-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after Helicobacter pylori infection J Biol Chem (2010) 285, 33691-33700. PubMed Europe PubMed DOI K
Nagler,D.K., Kraus,S., Feierler,J., Mentele,R., Lottspeich,F., Jochum,M. and Faussner,A. A cysteine-type carboxypeptidase, cathepsin X, generates peptide receptor agonists Int Immunopharmacol (2010) 10, 134-139. PubMed Europe PubMed DOI
Sevenich,L., Schurigt,U., Sachse,K., Gajda,M., Werner,F., Muller,S., Vasiljeva,O., Schwinde,A., Klemm,N., Deussing,J., Peters,C. and Reinheckel,T. Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice Proc Natl Acad Sci U S A (2010) 107, 2497-2502. PubMed Europe PubMed DOI K
Staudt,N.D., Aicher,W.K., Kalbacher,H., Stevanovic,S., Carmona,A.K., Bogyo,M. and Klein,G. Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts Haematologica (2010) 95, 1452-1460. PubMed Europe PubMed DOI

2009

Fonovic,U.P. and Kos,J. Efficient removal of cathepsin L from active cathepsin X using immunoprecipitation technique Acta Chim Slov (2009) 56, 985-988.
Jevnikar,Z., Obermajer,N., Pecar-Fonovic,U., Karaoglanovic-Carmona,A. and Kos,J. Cathepsin X cleaves the beta2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and alpha-actinin-1 binding Eur J Immunol (2009) 39, 3217-3227. PubMed Europe PubMed DOI
Kos,J., Jevnikar,Z. and Obermajer,N. The role of cathepsin X in cell signaling Cell Adh Migr (2009) 3, 164-166. PubMed Europe PubMed DOI PMC EPMC
Obermajer,N., Jevnikar,Z., Doljak,B., Sadaghiani,A.M., Bogyo,M. and Kos,J. Cathepsin X-mediated beta2 integrin activation results in nanotube outgrowth Cell Mol Life Sci (2009) 66, 1126-1134. PubMed Europe PubMed DOI
Obermajer,N., Doljak,B., Jamnik,P., Fonovic,U.P. and Kos,J. Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells Int J Biochem Cell Biol (2009) 41, 1685-1696. PubMed Europe PubMed DOI P
Obermajer,N., Magister,S., Kopitar,A.N., Tepes,B., Ihan,A. and Kos,J. Cathepsin X prevents an effective immune response against Helicobacter pylori infection Eur J Cell Biol (2009) 88, 461-471. PubMed Europe PubMed DOI

2008

Ahn,S.J., Kim,N.Y., Jeon,S.J., Sung,J.H., Je,J.E., Seo,J.S., Kim,M.S., Kim,J.K., Chung,J.K. and Lee,H.H. Molecular cloning, tissue distribution and enzymatic characterization of cathepsin X from olive flounder (Paralichthys olivaceus) Comp Biochem Physiol B Biochem Mol Biol (2008) 151, 203-212. PubMed Europe PubMed DOI
Cooke,G.S., Campbell,S.J., Bennett,S., Lienhardt,C., McAdam,K.P., Sirugo,G., Sow,O., Gustafson,P., Mwangulu,F., Van Helden,P., Fine,P., Hoal,E.G. and Hill,A.V. Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis Am J Respir Crit Care Med (2008) 178, 203-207. PubMed Europe PubMed DOI PMC EPMC
Jevnikar,Z., Obermajer,N., Bogyo,M. and Kos,J. The role of cathepsin X in the migration and invasiveness of T lymphocytes J Cell Sci (2008) 121, 2652-2661. PubMed Europe PubMed DOI
Kao,C.M. and Huang,F.L. Cloning and expression of carp cathepsin Z: possible involvement in yolk metabolism Comp Biochem Physiol B Biochem Mol Biol (2008) 149, 541-551. PubMed Europe PubMed DOI
Obermajer,N., Svajger,U., Bogyo,M., Jeras,M. and Kos,J. Maturation of dendritic cells depends on proteolytic cleavage by cathepsin X J Leukoc Biol (2008) 84, 1306-1315. PubMed Europe PubMed DOI
Obermajer,N., Repnik,U., Jevnikar,Z., Turk,B., Kreft,M. and Kos,J. Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins Immunology (2008) 124, 76-88. PubMed Europe PubMed DOI PMC EPMC

2006

Lechner,A.M., Assfalg-Machleidt,I., Zahler,S., Stoeckelhuber,M., Machleidt,W., Jochum,M. and Nagler,D.K. RGD-dependent binding of procathepsin X to integrin alpha vbeta 3 mediates cell-adhesive properties J Biol Chem (2006) 281, 39588-39597. PubMed Europe PubMed DOI
[YEAR:9-12-2006]Nagler,D.K., Lechner,A.M., Oettl,A., Kozaczynska,K., Scheuber,H.P., Gippner-Steppert,C., Bogner,V., Biberthaler,P. and Jochum,M. An enzyme-linked immunosorbent assay for human cathepsin X, a potential new inflammatory marker J Immunol Methods (9-12-2006) 308, 241-250. PubMed Europe PubMed DOI A
[YEAR:11-5-2006]Obermajer,N., Premzl,A., Zavasnik Bergant,T., Turk,B. and Kos,J. Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells Exp Cell Res (11-5-2006) 312, 2515-2527. PubMed Europe PubMed DOI

2005

[YEAR:5-1-2005]Appenzeller-Herzog,C., Nyfeler,B., Burkhard,P., Santamaria,I., Lopez-Otin,C. and Hauri,H.P. Carbohydrate- and conformation-dependent cargo capture for ER-Exit Mol Biol Cell (5-1-2005) 16, 1258-1267. PubMed Europe PubMed DOI PMC EPMC
[YEAR:8-4-2005]Devanathan,G., Turnbull,J.L., Ziomek,E., Purisima,E.O., Menard,R. and Sulea,T. Carboxy-monopeptidase substrate specificity of human cathepsin X Biochem Biophys Res Commun (8-4-2005) 329, 445-452. PubMed Europe PubMed DOI P
[YEAR:15-7-2005]Krueger,S., Kalinski,T., Hundertmark,T., Wex,T., Kuster,D., Peitz,U., Ebert,M., Nagler,D.K., Kellner,U., Malfertheiner,P., Naumann,M., Rocken,C. and Roessner,A. Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer J Pathol (15-7-2005) 207, 32-42. PubMed Europe PubMed DOI
[YEAR:15-4-2005]Nascimento,F.D., Rizzi,C.C., Nantes,I.L., Stefe,I., Turk,B., Carmona,A.K., Nader,H.B., Juliano,L. and Tersariol,I.L. Cathepsin X binds to cell surface heparan sulfate proteoglycans Arch Biochem Biophys (15-4-2005) 436, 323-332. PubMed Europe PubMed DOI
Puzer,L., Cotrin,S.S., Cezari,M.H., Hirata,I.Y., Juliano,M.A., Stefe,I., Turk,D., Turk,B., Juliano,L. and Carmona,A.K. Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L Biol Chem (2005) 386, 1191-1195. PubMed Europe PubMed DOI

2004

Lustigman,S., Zhang,J., Liu,J., Oksov,Y. and Hashmi,S. RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting Mol Biochem Parasitol (2004) 138, 165-170. PubMed Europe PubMed DOI
Menard,R. and Sulea,T. Cathepsin X [ISSN:0-12-079610-4] (2004) 2, 1113-1116. V
[YEAR:1-7-2004]Nagler,D.K., Kruger,S., Kellner,A., Ziomek,E., Menard,R., Buhtz,P., Krams,M., Roessner,A. and Kellner,U. Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia Prostate (1-7-2004) 60, 109-119. PubMed Europe PubMed DOI

2003

Kelley,G.O., Adkison,M.A., Leutenegger,C.M. and Hedrick,R.P. Myxobolus cerebralis: identification of a cathepsin Z-like protease gene (MyxCP-1) expressed during parasite development in rainbow trout, Oncorhynchus mykiss Exp Parasitol (2003) 105, 201-210. PubMed Europe PubMed DOI

2002

Nakazono,E., Kamata,Y. and Yamafuji,K. Determination of the mRNA sequence of cathepsin Y, a cysteine endopeptidase from rat spleen, and confirmation of its ubiquitous expression Biol Chem (2002) 383, 1971-1975. PubMed Europe PubMed DOI

2001

Menard,R., Therrien,C., Lachance,P., Sulea,T., Qo,H., Alvarez-Hernandez,A.D. and Roush,W.R. Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design Biol Chem (2001) 382, 839-845. PubMed Europe PubMed DOI I
[YEAR:6-3-2001]Therrien,C., Lachance,P., Sulea,T., Purisima,E.O., Qi,H., Ziomek,E., Alvarez-Hernandez,A., Roush,W.R. and Menard,R. Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities Biochemistry (6-3-2001) 40, 2702-2711. PubMed Europe PubMed DOI I

2000

[YEAR:15-3-2000]Guncar,G., Klemencic,I., Turk,B., Turk,V., Karaoglanovic-Carmona,A., Juliano,L. and Turk,D. Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease Structure (15-3-2000) 8, 305-313. PubMed Europe PubMed DOI S
Klemencic,I., Carmona,A.K., Cezari,M.H.S., Juliano,M.A., Juliano,L., Guncar,G., Turk,D., Krizaj,I., Turk,V. and Turk,B. Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase Eur J Biochem (2000) 267, 5404-5412. PubMed Europe PubMed DOI I
[YEAR:28-1-2000]Sivaraman,J., Nagler,D.K., Zhang,R., Menard,R. and Cygler,M. Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine J Mol Biol (28-1-2000) 295, 939-951. PubMed Europe PubMed DOI S

1999

Appenzeller,C., Andersson,H., Kappeler,F. and Hauri,H.P. The lectin ERGIC-53 is a cargo transport receptor for glycoproteins Nat Cell Biol (1999) 1, 330-334. PubMed Europe PubMed DOI
[YEAR:28-9-1999]Nagler,D.K., Zhang,R., Tam,W., Sulea,T., Purisima,E.O. and Menard,R. Human cathepsin X: A cysteine protease with unique carboxypeptidase activity Biochemistry (28-9-1999) 38, 12648-12654. PubMed Europe PubMed DOI

1998

Barrett,A.J. Cysteine-type carboxypeptidase, carboxypeptidase LB (1998) 1, 789-791. V
[YEAR:28-8-1998]Nagler,D.K. and Menard,R. Human cathepsin X: A novel cysteine protease of the papain family with a very short proregion and unique insertions FEBS Lett (28-8-1998) 434, 135-139. PubMed Europe PubMed DOI
[YEAR:3-7-1998]Santamaria,I., Velasco,G., Pendas,A.M., Fueyo,A. and Lopez-Otin,C. Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location J Biol Chem (3-7-1998) 273, 16816-16823. PubMed Europe PubMed DOI

1996

Lustigman,S., McKerrow,J.H., Shah,K., Lui,J., Huima,T., Hough,M. and Brotman,B. Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae J Biol Chem (1996) 271, 30181-30189. PubMed Europe PubMed DOI

1986

Lipperheide,C. and Otto,K. Improved purification and some properties of bovine lysosomal carboxypeptidase B Biochim Biophys Acta (1986) 880, 171-178. PubMed Europe PubMed
McDonald,J.K. and Barrett,A.J. Mammalian Proteases: a Glossary and Bibliography. Volume 2: Exopeptidases [ISSN:ISBN 0-12-079502-7] (1986)
Salvesen,G., Gay,N. and Walker,J. Cloning of a bovine protein homologous with cysteine proteinases and identification of the gene (1986) , 55-62.

1985

[YEAR:1-2-1985]Gay,N.J. and Walker,J.E. Molecular cloning of a bovine cathepsin Biochem J (1-2-1985) 225, 707-712. PubMed Europe PubMed PMC EPMC

1983

[YEAR:15-2-1983]Lones,M., Chatterjee,R., Singh,H. and Kalnitsky,G. Lysosomal carboxypeptidase B from rabbit lung purification and characterization Arch Biochem Biophys (15-2-1983) 221, 64-78. PubMed Europe PubMed DOI

1979

Dessaint,J.P., Katz,S.P. and Waksman,B.H. Catheptic carboxypeptidase B as a major component in "T-cell activating factor" of macrophages J Immunopharmacol (1979) 1, 399-414. PubMed Europe PubMed

1977

McDonald,J.K. and Schwabe,C. Intracellular exopeptidases (1977) , 311-391.

1976

Afroz,H., Otto,K., Muller,R. and Fuhge,P. On the specificity of bovine spleen cathepsin B2 Biochim Biophys Acta (1976) 452, 503-509. PubMed Europe PubMed

1975

McDonald,J.K. and Ellis,S. On the substrate specificity of cathepsins B1 and B2 including a new fluorogenic substrate for cathepsin B1 Life Sci (1975) 17, 1269-1276. PubMed Europe PubMed
Otto,K. and Riesenkonig,H. Improved purification of cathepsin B1 and cathepsin B2 Biochim Biophys Acta (1975) 379, 462-475. PubMed Europe PubMed

1974

[YEAR:25-11-1974]Ninjoor,V., Taylor,S.L. and Tappel,A.L. Purification and characterization of rat liver lysosomal cathepsin B2 Biochim Biophys Acta (25-11-1974) 370, 308-321. PubMed Europe PubMed
Taylor,S., Ninjoor,V., Dowd,D.M. and Tappel,A.L. Cathepsin B2 measurement by sensitive fluorometric ammonia analysis Anal Biochem (1974) 60, 153-162. PubMed Europe PubMed

1973

De Lumen,B.O. and Tappel,A.L. Histone hydrolase activity of rat liver lysosomal cathepsin B2 Biochim Biophys Acta (1973) 293, 217-225. PubMed Europe PubMed

1971

Mellors,A. A thiol-dependent cathepsin IV in rat liver lysosomes Arch Biochem Biophys (1971) 144, 281-285. PubMed Europe PubMed
Otto,K. Cathepsins B1 and B2 (1971) , 1-28.

1941

Fruton,J.S., Irving,G.W., Jr. and Bergmann,M. On the proteolytic enzymes of animal tissues. III. The proteolytic enzymes of beef spleen, beef kidney and swine kidney. Classification of the cathepsins J Biol Chem (1941) 141, 763-774.

1939

Fruton,J.S. and Bergmann,M. On the proteolytic enzymes of animal tissues. I. Beef spleen J Biol Chem (1939) 130, 19-27.