Substrates for peptidase C01.013: cathepsin X

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
consensus aminoacyl-Pro bond peptide+Pro N - - - NPe Pro - - - Menard & Sulea, 2004
Leu-Trp-Met Leu-Trp+Met N - - Leu Trp Met - - - Barrett, 1998
Leu-Trp-Met-Arg Leu-Trp-Met+Arg N - Leu Trp Met Arg - - - Barrett, 1998
Leu-Trp-Met-Arg-Phe Leu-Trp-Met-Arg+Phe N Leu Trp Met Arg Phe - - - Barrett, 1998
Leu-Trp-Met-Arg-Phe-Ala Leu-Trp-Met-Arg-Phe+Ala N Trp Met Arg Phe Ala - - - Barrett, 1998
Val-Leu-Ser Val-Leu+Ser N - - Val Leu Ser - - - Barrett, 1998
Val-Leu-Ser-Glu Val-Leu-Ser+Glu N - Val Leu Ser Glu - - - Barrett, 1998
Val-Leu-Ser-Glu-Gly Val-Leu-Ser-Glu+Gly N Val Leu Ser Glu Gly - - - Barrett, 1998