Substrates for peptidase C01.013: cathepsin X

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Abz-Phe-Arg-NPh-OH	Abz-Phe-Arg+NPh-OH	S	-	Abz	Phe	Arg	Nph	-	-	-	Menard & Sulea, 2004
Abz-Phe-Glu-Lys(Dnp)-OH	Abz-Phe-Glu+Lys(Dnp)-OH	S	-	Abz	Phe	Glu	Lyd	-	-	-	Jevnikar et al., 2009
Bz-Arg-NH2	Bz-Arg+NH2	S	-	-	Bz	Arg	NH2	-	-	-	Barrett, 1998
Bz-Gly-Arg	Bz-Gly+Arg	S	-	-	Bz	Gly	Arg	-	-	-	Barrett, 1998
Z-Glu-Tyr	Z-Glu+Tyr	S	-	-	Z	Glu	Tyr	-	-	-	Barrett, 1998
Z-Gly-Arg	Z-Gly+Arg	S	-	-	Z	Gly	Arg	-	-	-	Barrett, 1998
Z-Gly-Asp	Z-Gly+Asp	S	-	-	Z	Gly	Asp	-	-	-	Barrett, 1998
Z-Gly-Gly	Z-Gly+Gly	S	-	-	Z	Gly	Gly	-	-	-	Barrett, 1998
Z-Gly-Leu	Z-Gly+Leu	S	-	-	Z	Gly	Leu	-	-	-	Barrett, 1998
Z-Gly-Met	Z-Gly+Met	S	-	-	Z	Gly	Met	-	-	-	Barrett, 1998
Z-Gly-Phe	Z-Gly+Phe	S	-	-	Z	Gly	Phe	-	-	-	Barrett, 1998
Z-Gly-Ser	Z-Gly+Ser	S	-	-	Z	Gly	Ser	-	-	-	Barrett, 1998
Z-Phe-Arg-NHMec	Z-Phe-Arg+NHMec	S	-	Z	Phe	Arg	AMC	-	-	-	Menard & Sulea, 2004