Substrates for peptidase A02.002: HIV-2 retropepsin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
actin, alpha cardiac muscle 1	P68032	3-377	peptide-Gly270+Met-peptide	N		Ser	Phe	Ile	Gly	Met	Glu	Ser	Ala	Tomasselli et al., 1991	26111
calmodulin	P62157	2-149	peptide-Asn171+Tyr-peptide	P		Gly	Gln	Val	Asn	Tyr	Glu	Glu	Phe	Tomasselli et al., 1991	26103
calmodulin	P62157	2-149	peptide-Phe175+Val-peptide	P		Tyr	Glu	Glu	Phe	Val	Gln	Met	Met	Tomasselli et al., 1991	26104
calmodulin	P62157	2-149	peptide-Glu79+Ala-peptide	P		Asn	Pro	Thr	Glu	Ala	Glu	Leu	Gln	Tomasselli et al., 1991	26105
calmodulin	P62157	2-149	peptide-Gly95+Thr-peptide	P		Asp	Gly	Asn	Gly	Thr	Ile	Asp	Phe	Tomasselli et al., 1991	26106
calmodulin	P62157	2-149	peptide-Ala136+Ala-peptide	P		Tyr	Ile	Ser	Ala	Ala	Glu	Leu	Arg	Tomasselli et al., 1991	26107
calmodulin	P62157	2-149	peptide-Met143+Thr-peptide	P		Arg	His	Val	Met	Thr	Asn	Leu	Gly	Tomasselli et al., 1991	26108
HIV-1 gag polyprotein junction B-based peptide			Lys-Ala-Arg-Val-Nle+Nph-Glu-Ala-Nle-NH2	P		Ala	Arg	Val	Nle	Nph	Glu	Ala	Nle	Dunn, 2004
HIV-1 gag polyprotein MA/CA junction-based peptide 1			Tyr-Val-Ser-Gln-Asn-Phe+Pro-Ile-Val-Gln-Asn-Arg	P		Ser	Gln	Asn	Phe	Pro	Ile	Val	Gln	Dunn, 2004
HIV-1 gag polyprotein MA/CA junction-based peptide 2			Ser-Gln-Asn-Tyr+Pro-Ile-Val-Gln	P		Ser	Gln	Asn	Tyr	Pro	Ile	Val	Gln	Dunn, 2004
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya+Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Tyr	Leu	Val	Cya	Gly	Glu	Arg	Gly	Tomasselli et al., 1991	26109
interleukin-1 beta precursor	P01584	1-269	peptide-Phe23+Phe-peptide	N		Asp	Asp	Leu	Phe	Phe	Glu	Ala	Asp	Tomasselli et al., 1991
polyadenylate-binding protein 1	P11940	1-636	peptide-Ser237+Phe-peptide	P		Gly	Phe	Val	Ser	Phe	Glu	Arg	His	Alvarez et al., 2006
polyadenylate-binding protein 1	P11940	1-636	peptide-Met410+Ala-peptide	P		Gly	Tyr	Phe	Met	Ala	Ala	Ile	Pro	Alvarez et al., 2006
polyadenylate-binding protein 1	P11940	1-636	peptide-Met477+Ser-peptide	P		Pro	Arg	Val	Met	Ser	Thr	Gln	Arg	Alvarez et al., 2006
troponin C, skeletal muscle	P02585	2-160	peptide-Leu96+Ala-peptide	N		Glu	Glu	Glu	Leu	Ala	Glu	Cys	Phe	Tomasselli et al., 1991	26079
troponin C, skeletal muscle	P02585	2-160	peptide-Leu116+Ala-peptide	N		Pro	Glu	Glu	Leu	Ala	Glu	Ile	Phe	Tomasselli et al., 1991
Val-Ser-Ala-Asn-Tyr-Pro-Ile-Val-Gln			peptide-Tyr5+Pro-peptide	N	AA	Ser	Ala	Asn	Tyr	Pro	Ile	Val	Gln	Eizert et al., 2008
Val-Ser-Gln-Asn-Leu-Pro-Ile-Val-Gln			peptide-Leu5+Pro-peptide	N	AA	Ser	Gln	Asn	Leu	Pro	Ile	Val	Gln	Eizert et al., 2008
Val-Ser-Gln-Asn-Met-Pro-Ile-Val-Gln			peptide-Met5+Pro-peptide	N	AA	Ser	Gln	Asn	Met	Pro	Ile	Val	Gln	Eizert et al., 2008
Val-Ser-Gln-Asn-Phe-Pro-Ile-Val-Gln			peptide-Phe5+Pro-peptide	N	AA	Ser	Gln	Asn	Phe	Pro	Ile	Val	Gln	Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln			peptide-Tyr5+Pro-peptide	N	AA	Ser	Gln	Asn	Tyr	Pro	Ile	Val	Gln	Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln			peptide-Tyr5+Pro-peptide	N	AA	Ser	Gln	Asn	Tyr	Pro	Ile	Val	Gln	Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln			peptide-Tyr5+Pro-peptide	N	AA	Ser	Gln	Asn	Tyr	Pro	Ile	Val	Gln	Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Val-Ile-Val			Val-Ser-Gln-Asn-Tyr+Val-Ile-Val	N		Ser	Gln	Asn	Tyr	Val	Ile	Val	-	Dunn, 2004
Val-Ser-Gly-Asn-Tyr-Pro-Ile-Val-Gln			peptide-Tyr5+Pro-peptide	N	AA	Ser	Gly	Asn	Tyr	Pro	Ile	Val	Gln	Eizert et al., 2008
Val-Ser-Leu-Asn-Tyr-Pro-Ile-Val-Gln			peptide-Tyr5+Pro-peptide	N	AA	Ser	Leu	Asn	Tyr	Pro	Ile	Val	Gln	Eizert et al., 2008
Val-Ser-Lys-Asn-Tyr-Pro-Ile-Val-Gln			peptide-Tyr5+Pro-peptide	N	AA	Ser	Lys	Asn	Tyr	Pro	Ile	Val	Gln	Eizert et al., 2008
Val-Ser-Phe-Asn-Tyr-Pro-Ile-Val-Gln			peptide-Tyr5+Pro-peptide	N	AA	Ser	Phe	Asn	Tyr	Pro	Ile	Val	Gln	Eizert et al., 2008
Val-Ser-Val-Asn-Tyr-Pro-Ile-Val-Gln			peptide-Tyr5+Pro-peptide	N	AA	Ser	Val	Asn	Tyr	Pro	Ile	Val	Gln	Eizert et al., 2008