$VAR1 = undef;

Summary for peptidase A02.002: HIV-2 retropepsin

Names
MEROPS Name	HIV-2 retropepsin
Other names	HIV-2 protease, retropepsin (human immunodeficiency virus 2)

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.002
Holotype	HIV-2 retropepsin (human immunodeficiency virus 2), Uniprot accession Q76634 (peptidase unit: 516-611), MERNUM MER0001468
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00026
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.47
Enzymology	BRENDA database
Proteolytic events	CutDB database (9 cleavages)
Physiology	Processing of viral polyprotein of human immunodeficiency virus type 2.
Pharmaceutical relevance	Drug target for human immunodeficiency virus infection.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	S/q/Nve/yfmpa/IE/v/Qf (based on 30 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	2	0	2	1	0	0	2
Pro	2	1	0	0	14	0	0	1
Ala	1	1	0	1	5	1	2	1
Val	0	1	6	0	2	0	15	0
Leu	0	2	1	3	0	0	3	0
Ile	0	1	1	0	0	16	2	0
Met	0	0	0	4	1	0	1	1
Phe	0	3	1	4	2	0	0	4
Tyr	3	1	0	11	1	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	16	0	1	1	1	0	1	0
Thr	0	0	1	0	2	1	0	0
Cys	0	0	0	0	0	0	1	0
Asn	1	0	16	1	0	1	0	0
Gln	0	10	0	0	0	1	1	15
Asp	2	1	0	0	0	0	1	1
Glu	1	3	3	1	0	10	1	0
Lys	0	1	0	0	0	0	0	0
Arg	1	2	0	0	0	0	2	2
His	0	1	0	0	0	0	0	1