Structure for peptidase A02.002: HIV-2 retropepsin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
4UPJ	human immunodeficiency virus 2	1.90 Å	complex with U097410
The dimer is shown. The active site residue Asp129 is shown in ball-and-stick representation in pink (one from each monomer). Bound inhibitor is shown in grey in ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
human immunodeficiency virus 2
complex with inhibitor CGP 53820	2.30 Å	1HII	1HII	1HII	1HII	1HII	1HII	Priestle et al., 1995
mature peptidase	1.90 Å	1HSH	1HSH	1HSH	1HSH	1HSH	1HSH	Chen et al., 1994
mature peptidase	2.50 Å	1HSI	1HSI	1HSI	1HSI	1HSI	1HSI	Chen et al., 1994
complex with BILA 1906	1.70 Å	1IDA	1IDA	1IDA	1IDA	1IDA	1IDA	Tong et al., 1995
complex with BILA 2450	2.20 Å	1IDB	1IDB	1IDB	1IDB	1IDB	1IDB	Tong et al., 1995
Lys57Leu mutant; complex with NOA-His-CHA-PSI[CH(OH)CH(OH)]Val-Ile-APY	2.50 Å	1IVP	1IVP	1IVP	1IVP	1IVP	1IVP	Mulichak et al., 1993
Lys57Leu mutant; complex with QNC-Asn-CHA-PSI[CH(OH)CH(OH)]Val-NPT	2.60 Å	1IVQ	1IVQ	1IVQ	1IVQ	1IVQ	1IVQ	Mulichak et al., 1993
complex with inhibitor containing an (hydroxyethyl) amide isostere	2.50 Å	1JLD	1JLD	1JLD	1JLD	1JLD	1JLD	Beaulieu et al., 1997
theoretical model; complex with N-ac-Val-Val-Sta-Ala-Sta	0.00 Å	1PHV	1PHV	1PHV	1PHV	1PHV	1PHV
Lys57Leu mutant	2.00 Å	2HPE	2HPE	2HPE	2HPE	2HPE	2HPE
Lys57Leu mutant	3.00 Å	2HPF	2HPF	2HPF	2HPF	2HPF	2HPF
complex with Phe-Val-Phe-PSI(CH2NH)-Leu-Glu-Ile amide inhibitor	2.20 Å	2MIP	2MIP	2MIP	2MIP	2MIP	2MIP	Tong et al., 1993
theoretical model; complex with renin inhibitor H261	0.00 Å	2PHV	2PHV	2PHV	2PHV	2PHV	2PHV
complex with clinical drug darunavir	1.20 Å	3EBZ	3EBZ	3EBZ	3EBZ	3EBZ	3EBZ
complex with antiviral inhibitor GRL-06579a	1.18 Å	3EC0	3EC0	3EC0	3EC0	3EC0	3EC0
complex with antiviral inhibitor GRL-98065	1.18 Å	3ECG	3ECG	3ECG	3ECG	3ECG	3ECG
wild-type; complex with antiviral drug amprenavir	1.51 Å	3S45	3S45	3S45	3S45	3S45	3S45
complex with U096333	2.50 Å	3UPJ	3UPJ	3UPJ	3UPJ	3UPJ	3UPJ	Thaisrivongs et al., 1995
complex with U097410	1.90 Å	4UPJ	4UPJ	4UPJ	4UPJ	4UPJ	4UPJ	Thaisrivongs et al., 1995
complex with U99283	2.30 Å	5UPJ	5UPJ	5UPJ	5UPJ	5UPJ	5UPJ	Romines et al., 1995
complex with U99294	2.34 Å	6UPJ	6UPJ	6UPJ	6UPJ	6UPJ	6UPJ	Romines et al., 1995