| Activity |
|---|
| Catalytic type | Aspartic |
| Peplist | Included in the Peplist with identifier PL00002 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.3
|
| Enzymology | BRENDA database |
| Proteolytic events | CutDB database (2 cleavages) |
| Activity status | human: active (Tang, 2004)
mouse: active (by similarity)
|
| Physiology | Contributes to proteolysis in the vertebrate stomach. In man, expressed primarily in gastric chief cells, but also in lung (Foster et al., 2004). Proenzyme also occurs in seminal fluid (Szecsi et al., 1995). |
| Pharmaceutical relevance | Polymorphism correlates with gastric ulceration, and it has been suggested that restriction-linked polymorphism of gastricsin may be useful as a marker for a genetic predisposition to gastric body ulcer (Ohtaki et al., 1997). |
|
Other databases
| WIKIPEDIA | http://en.wikipedia.org/wiki/Gastricsin |
| Cleavage site specificity |
Explanations of how to interpret the
following cleavage site sequence logo and specificity matrix can be found here. |
|---|
| Cleavage pattern | -/-/-/fy -/-/-/- (based on 50 cleavages) |
