Structure for peptidase S08.071: furin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1P8J	Mus musculus	2.60 Å	homooctomer
One monomer of the octamer is shown. Catalytic residues are shown in ball-and-stick representation: Asp175 in pink, His213 in purple, Asn295 in dark pink and Ser385 in orange.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
mature peptidase	2.30 Å	4OMC	4OMC	4OMC	4OMC	4OMC	4OMC	Dahms et al., 2014
mature peptidase	2.70 Å	4OMD	4OMD	4OMD	4OMD	4OMD	4OMD	Dahms et al., 2014
mature peptidase	2.15 Å	4RYD	4RYD	4RYD	4RYD	4RYD	4RYD	Hardes et al., 2015
crystal structure of unglycosylated apo human furin @1.89a	1.89 Å	4Z2A	4Z2A	4Z2A	4Z2A	4Z2A	4Z2A
complex with the inhibitory antibody nb14	2.00 Å	5JMO	5JMO	5JMO	5JMO	5JMO	5JMO
structure of the unliganded form of the proprotein convertase furin.	1.80 Å	5JXG	5JXG	5JXG	5JXG	5JXG	5JXG
complex with meta- guanidinomethyl-phac-rvr-amba	2.00 Å	5JXH	5JXH	5JXH	5JXH	5JXH	5JXH
structure of the unliganded form of the proprotein convertase furin inpresence of edta.	2.00 Å	5JXI	5JXI	5JXI	5JXI	5JXI	5JXI
complex to meta- guanidinomethyl-phac-rvr-amba in presence of edta	2.00 Å	5JXJ	5JXJ	5JXJ	5JXJ	5JXJ	5JXJ
complex with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n	1.90 Å	5MIM	5MIM	5MIM	5MIM	5MIM	5MIM
complex with the competitive inhibitor phac-cit-val-arg-amba	1.90 Å	6EQV	6EQV	6EQV	6EQV	6EQV	6EQV
complex with the competitive inhibitor 4-aminomethyl-phenylacetyl-arg-val-arg-amba	1.99 Å	6EQW	6EQW	6EQW	6EQW	6EQW	6EQW
complex with the competitive inhibitor arg-arg-arg-val-arg-amba	1.99 Å	6EQX	6EQX	6EQX	6EQX	6EQX	6EQX
complex with the cyclic peptide c[succinyl-phe-2-nal-(arg)4-lys]-arg-4-amba	2.00 Å	6HLB	6HLB	6HLB	6HLB	6HLB	6HLB
complex with the cyclic peptide c[succinyl-phe-2-nal-(arg)3-lys]-lys-4-amba	2.10 Å	6HLD	6HLD	6HLD	6HLD	6HLD	6HLD
complex with the p6-p2-cyclized peptide h-lys-arg-arg-tle-lys-4-amba	1.99 Å	6HLE	6HLE	6HLE	6HLE	6HLE	6HLE
complex with the cyclic peptide c[glutaryl-arg-arg-lys]-arg-4-amba	1.90 Å	6HZA	6HZA	6HZA	6HZA	6HZA	6HZA
complex with the cyclic inhibitor c[glutaryl-arg-arg-lys]-lys-4-amba	1.90 Å	6HZB	6HZB	6HZB	6HZB	6HZB	6HZB
complex with the cyclic inhibitor c[glutaryl-bvk-lys-arg-arg-tle-lys]-4-amba	1.90 Å	6HZC	6HZC	6HZC	6HZC	6HZC	6HZC
complex with the cyclic inhibitor c[glutaryl-arg-arg-arg-lys]-arg-4-amba	1.90 Å	6HZD	6HZD	6HZD	6HZD	6HZD	6HZD
Mus musculus
homooctomer	2.60 Å	1P8J	1P8J	1P8J	1P8J	1P8J	1P8J	Henrich et al., 2003