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Literature for peptidase S08.071: furin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Li,X., Liu,C. and Hu,H.
    The expanding role of Furin in human Disease: A comprehensive review
    Gene (2026) 981, 149969-149969. PubMed  Europe PubMed DOI
    2. 2025
  2. Al Madhoun,A., Mohammad,A., Abu-Farha,M., Hebbar,P., Haddad,D., Miranda,L., Channanath,A., Nizam,R., Bourashed,M., Ahmad,R., Abubaker,J., Thanaraj,T.A. and Al-Mulla,F.
    FURIN R81C Variant: A Link to Type 2 Diabetes via Impaired Enzymatic Activity
    Am J Physiol Endocrinol Metab (2025) PubMed  Europe PubMed DOI
  3. Bulliard,M., Pinjusic,K., Iacobucci,L., Schmuziger,C., Fournier,N. and Constam,D.B.
    Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma
    Nat Commun (2025) 16, 2354-2354. PubMed  Europe PubMed DOI  PMC  EPMC  K
  4. Holoubek,J., Salat,J., Matkovic,M., Bednar,P., Novotny,P., Hradilek,M., Majerova,T., Rosendal,E., Eyer,L., Fortova,A., Berankova,M., Bell-Sakyi,L., Overby,A.K., Cavalli,A., Bonomi,M., Rey,F.A. and Ruzek,D.
    Irreversible furin cleavage site exposure renders immature tick-borne flaviviruses fully infectious
    Nat Commun (2025) 16, 7491-7491. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Klaushofer,R., Bloch,K., Eder,L.S., Marzaro,S., Schubert,M., Bottcher-Friebertshauser,E., Brandstetter,H. and Dahms,S.O.
    Structural insights into proprotein convertase activation facilitate the engineering of highly specific furin inhibitors
    Nat Commun (2025) 16, 8206-8206. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Lumi Tanaka Dino,C., Maria Cavalli,B., Konzen Klein,C., Paes Gomes da Silva,F., Henrique Borges,N., Catharina Joaquim,A., Rodrigues Dos Santos,T., de Araujo,N., Baena Cartens,L., Simoes Florido Almeida,A.C., Nagashima,S., Busatta Vaz De Paula,C., Machado-Souza,C., de Noronha,L. and Bordignon Nogueira,M.
    Placental infection by SARS-CoV-2: exploring alternative entry pathways
    Tissue Barriers (2025) , 2585246-2585246. PubMed  Europe PubMed DOI
  7. Siner,J.I., Barber-Meyer,S., Samelson-Jones,B.J., Mech,L.D., Arruda,V.R. and Crudele,J.M.
    Ancient origin of the furin sequence in the wolf F8 gene
    Open Vet J (2025) 15, 3216-3222. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Xie,X.Y., Wang,L., Xie,S.Q., Zhou,G.F., Wen,Q.X., Ma,Y.L., Zhang,Q.L., Yan,X.X., Luo,B., Chen,J., Song,L., Chen,X., Li,C.L., Pan,Q.L., Liu,Y., Xiang,X.J. and Chen,G.J.
    Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation
    Autophagy (2025) , 1-22. PubMed  Europe PubMed DOI
    9. 2024
  9. Ayyubova,G., Gychka,S.G., Nikolaienko,S.I., Alghenaim,F.A., Teramoto,T., Shults,N.V. and Suzuki,Y.J.
    The Role of Furin in the Pathogenesis of COVID-19-Associated Neurological Disorders
    Life (Basel) (2024) 14 PubMed  Europe PubMed DOI  PMC  EPMC
  10. Chauhan,P., Xue,Y., Kim,H.S., Fisher,A.L., Babitt,J.L. and Christian,J.L.
    The prodomain of bone morphogenetic protein 2 promotes dimerization and cleavage of BMP6 homodimers and BMP2/6 heterodimers
    J Biol Chem (2024) , 107790-107790. PubMed  Europe PubMed DOI
  11. Choi,A., Kots,E.D., Singleton,D.T., Weinstein,H. and Whittaker,G.R.
    Analysis of the molecular determinants for furin cleavage of the spike protein S1/S2 site in defined strains of the prototype coronavirus murine hepatitis virus (MHV)
    Virus Res (2024) 340, 199283-199283. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Dicenta,V., Pelzer,A., Laspa,Z., Castor,T., Gawaz,M.P. and Rohlfing,A.K.
    The subtilisin-like protease furin regulates hemin-induced CD63 surface expression on platelets
    Biochem Biophys Res Commun (2024) 701, 149629-149629. PubMed  Europe PubMed DOI  I
  13. Fry,H., Mazidi,M., Kartsonaki,C., Clarke,R., Walters,R.G., Chen,Z. and Millwood,I.Y.
    The Role of Furin and Its Therapeutic Potential in Cardiovascular Disease Risk
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC  V
  14. Jiang,X., Li,D., Maghsoudloo,M., Zhang,X., Ma,W. and Fu,J.
    Targeting furin, a cellular proprotein convertase, for COVID-19 prevention and therapeutics
    Drug Discov Today (2024) , 104026-104026. PubMed  Europe PubMed DOI  V
  15. Kubo,Y., Hans,M.B., Nakamura,T. and Hayashi,H.
    The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  16. Lange,R.W., Bloch,K., Heindl,M.R., Wollenhaupt,J., Weiss,M.S., Brandstetter,H., Klebe,G., Falcone,F.H., Bottcher-Friebertshauser,E., Dahms,S.O. and Steinmetzer,T.
    Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors
    ChemMedChem (2024) , e202400057-e202400057. PubMed  Europe PubMed DOI
  17. Su,W., Ahmad,I., Wu,Y., Tang,L., Khan,I., Ye,B., Liang,J., Li,S. and Zheng,Y.H.
    Furin Egress from the TGN is Regulated by Membrane-Associated RING-CH Finger (MARCHF) Proteins and Ubiquitin-Specific Protease 32 (USP32) via Nondegradable K33-Polyubiquitination
    Adv Sci (Weinh) (2024) , e2403732-e2403732. PubMed  Europe PubMed DOI
  18. Tanriverdi,O., Alkan,A., Karaoglu,T., Kitapli,S. and Yildiz,A.
    COVID-19 and Carcinogenesis: Exploring the Hidden Links
    Cureus (2024) 16, e68303-e68303. PubMed  Europe PubMed DOI  PMC  EPMC  V
  19. Wichaiyo,S., Koonyosying,P. and Morales,N.P.
    Functional Roles of Furin in Cardio-Cerebrovascular Diseases
    ACS Pharmacol Transl Sci (2024) 7, 570-585. PubMed  Europe PubMed DOI  PMC  EPMC  V
  20. Wu,A., Shi,K., Wang,J., Zhang,R. and Wang,Y.
    Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors
    Eur J Med Chem (2024) 263, 115923-115923. PubMed  Europe PubMed DOI  V
  21. Yao,K., Zhan,X.Y., Feng,M., Yang,K.F., Zhou,M.S. and Jia,H.
    Furin, ADAM, and gamma-secretase: Core regulatory targets in the Notch pathway and the therapeutic potential for breast cancer
    Neoplasia (2024) 57, 101041-101041. PubMed  Europe PubMed DOI  V
  22. Zhang,W., Shi,K., Hsueh,F.C., Mendoza,A., Ye,G., Huang,L., Perlman,S., Aihara,H. and Li,F.
    Structural basis for mouse receptor recognition by bat SARS2-like coronaviruses
    Proc Natl Acad Sci U S A (2024) 121, e2322600121-e2322600121. PubMed  Europe PubMed DOI
    23. 2023
  23. Cendron,L., Rothenberger,S., Cassari,L., Dettin,M. and Pasquato,A.
    Proprotein convertases regulate trafficking and maturation of key proteins within the secretory pathway
    Adv Protein Chem Struct Biol (2023) 133, 1-54. PubMed  Europe PubMed DOI  V
  24. Douglas,L.E.J., Reihill,J.A., Montgomery,B.M. and Martin,S.L.
    Furin as a therapeutic target in cystic fibrosis airways disease
    Eur Respir Rev (2023) 32 PubMed  Europe PubMed DOI  PMC  EPMC  V
  25. Kellnerova,S., Huber,S., Massri,M., Fleischer,V., Losso,K., Sarg,B., Kremser,L., Talasz,H., He,X., Varrone,E., Brigotti,M., Ardissino,G., Orth-Holler,D. and Wurzner,R.
    Enzymatic Cleavage of Stx2a in the Gut and Identification of Pancreatic Elastase and Trypsin as Possible Main Cleavers
    Microorganisms (2023) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  26. Latini,A., De Benedittis,G., Colafrancesco,S., Perricone,C., Novelli,G., Novelli,L., Priori,R., Ciccacci,C. and Borgiani,P.
    PCSK3 Overexpression in Sjogren's Syndrome Patients May Be Regulated by rs4932178 SNP in Its Promoter Region and Correlates with IFN-gamma Gene Expression
    Genes (Basel) (2023) 14 PubMed  Europe PubMed DOI  PMC  EPMC
  27. Marafie,S.K. and Al-Mulla,F.
    An Overview of the Role of Furin in Type 2 Diabetes
    Cells (2023) 12 PubMed  Europe PubMed DOI  PMC  EPMC  V
  28. Pacheco,A., Issaian,A., Davis,J., Anderson,N., Nemkov,T., Paukovich,N., Henen,M.A., Vogeli,B., Sikela,J.M. and Hansen,K.
    Proteolytic activation of human-specific Olduvai domains by the furin protease
    Int J Biol Macromol (2023) 234, 123041-123041. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Xie,H., Bastepe,I., Zhou,W., Ay,B., Ceraj,Z., Portales-Castillo,I.A., Liu,E.S., Burnett-Bowie,S.M., Juppner,H., Rhee,E.P., Bastepe,M. and Simic,P.
    1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage
    JCI Insight (2023) 8 PubMed  Europe PubMed DOI  PMC  EPMC
    30. 2022
  30. Mustafa,Z., Kalbacher,H. and Burster,T.
    Occurrence of a novel cleavage site for cathepsin G adjacent to the polybasic sequence within the proteolytically sensitive activation loop of the SARS-CoV-2 Omicron variant: The amino acid substitution N679K and P681H of the spike protein
    PLoS ONE (2022) 17, e0264723-e0264723. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Peng,H., Fan,Y., Li,J., Zheng,X., Zhong,C., Zhu,Z., He,Y., Zhang,M. and Zhang,Y.
    DNA Methylation of the Natriuretic Peptide System Genes and Ischemic Stroke: Gene-Based and Gene Set Analyses
    Neurol Genet (2022) 8, e679-e679. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Singh,S., O'Reilly,S., Gewaid,H., Bowie,A.G., Gautier,V. and Worrall,D.M.
    Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and Replication
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  33. Sohaei,D., Hollenberg,M., Janket,S.J., Diamandis,E.P., Poda,G. and Prassas,I.
    The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology
    Crit Rev Clin Lab Sci (2022) , 1-16. PubMed  Europe PubMed DOI  V
  34. Zhang,Y., Gao,X., Bai,X., Yao,S., Chang,Y.Z. and Gao,G.
    The emerging role of furin in neurodegenerative and neuropsychiatric diseases
    Transl Neurodegener (2022) 11, 39-39. PubMed  Europe PubMed DOI  PMC  EPMC  V
    35. 2021
  35. Al-Mulla,F., Mohammad,A., Al Madhoun,A., Haddad,D., Ali,H., Eaaswarkhanth,M., John,S.E., Nizam,R., Channanath,A., Abu-Farha,M., Ahmad,R., Abubaker,J. and Thanaraj,T.A.
    ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19
    Heliyon (2021) 7, e06133-e06133. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Ayipo,Y.O., Yahaya,S.N., Alananzeh,W.A., Babamale,H.F. and Mordi,M.N.
    Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside
    Infect Genet Evol (2021) 93, 104944-104944. PubMed  Europe PubMed DOI  PMC  EPMC  V  I
  37. Berdowska,I. and Matusiewicz,M.
    Cathepsin L, transmembrane peptidase/serine subfamily member 2/4, and other host proteases in COVID-19 pathogenesis - with impact on gastrointestinal tract
    World J Gastroenterol (2021) 27, 6590-6600. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Bitossi,C., Frasca,F., Viscido,A., Oliveto,G., Scordio,M., Belloni,L., Cimino,G., Pietropaolo,V., Gentile,M., d'Ettorre,G., Midulla,F., Trancassini,M., Antonelli,G., Pierangeli,A. and Scagnolari,C.
    SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients
    Microorganisms (2021) 9 PubMed  Europe PubMed DOI  PMC  EPMC
  39. Cubuk,H. and Ozbil,M.
    Comparison of clinically approved molecules on SARS-CoV-2 drug target proteins: a molecular docking study
    Turk J Chem (2021) 45, 35-41. PubMed  Europe PubMed DOI  PMC  EPMC  I
  40. de Souza,A.A., de Andrade,D.M., Siqueira,F.D.S., Di Iorio,J.F., Veloso,M.P., Coelho,C.M., Viegas Junior,C., Gontijo,V.S., Dos Santos,M.H., Meneghetti,M.C.Z., Nader,H.B., Tersariol,I.L.D.S., Juliano,L., Juliano,M.A. and Judice,W.A.S.
    Semysinthetic biflavonoid Morelloflavone-7,4',7'',3''',4'''-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin
    Biochim Biophys Acta Gen Subj (2021) 1865, 130016-130016. PubMed  Europe PubMed DOI  I
  41. Dong,S., Lu,Y., Peng,G., Li,J., Li,W., Li,M., Wang,H., Liu,L. and Zhao,Q.
    Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway
    Dig Liver Dis (2021) PubMed  Europe PubMed DOI
  42. Gobeil,S.M., Janowska,K., McDowell,S., Mansouri,K., Parks,R., Manne,K., Stalls,V., Kopp,M.F., Henderson,R., Edwards,R.J., Haynes,B.F. and Acharya,P.
    D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction
    Cell Rep (2021) 34, 108630-108630. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Graier,T., Golob-Schwarzl,N., Weger,W., Benezeder,T., Painsi,C., Salmhofer,W. and Wolf,P.
    Furin Expression in Patients With Psoriasis-A Patient Cohort Endangered to SARS-COV2?
    Front Med (Lausanne) (2021) 8, 624462-624462. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Hu,X., Hai,Z., Wu,C., Zhan,W. and Liang,G.
    A Golgi-Targeting and Dual-Color "Turn-On" Probe for Spatially Precise Imaging of Furin
    Anal Chem (2021) 93, 1636-1642. PubMed  Europe PubMed DOI
  45. Johnson,B.A., Xie,X., Bailey,A.L., Kalveram,B., Lokugamage,K.G., Muruato,A., Zou,J., Zhang,X., Juelich,T., Smith,J.K., Zhang,L., Bopp,N., Schindewolf,C., Vu,M., Vanderheiden,A., Winkler,E.S., Swetnam,D., Plante,J.A., Aguilar,P., Plante,K.S., Popov,V., Lee,B., Weaver,S.C., Suthar,M.S., Routh,A.L., Ren,P., Ku,Z., An,Z., Debbink,K., Diamond,M.S., Shi,P.Y., Freiberg,A.N. and Menachery,V.D.
    Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
    Nature (2021) PubMed  Europe PubMed DOI
  46. Kermani,N.Z., Song,W.J., Badi,Y., Versi,A., Guo,Y., Sun,K., Bhavsar,P., Howarth,P., Dahlen,S.E., Sterk,P.J., Djukanovic,R., Adcock,I.M. and Chung,K.F.
    Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma
    Respir Res (2021) 22, 10-10. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Khoury,E.E., Knaney,Y., Fokra,A., Kinaneh,S., Azzam,Z., Heyman,S.N. and Abassi,Z.
    Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease
    J Cell Mol Med (2021) PubMed  Europe PubMed DOI
  48. Kumar Verma,A., Kumar,V., Singh,S., Goswami,B.C., Camps,I., Sekar,A., Yoon,S. and Lee,K.W.
    Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies
    Biomed Pharmacother (2021) 137, 111356-111356. PubMed  Europe PubMed DOI  PMC  EPMC  I
  49. Lam van,T.V., Heindl,M.R., Schlutt,C., Bottcher-Friebertshauser,E., Bartenschlager,R., Klebe,G., Brandstetter,H., Dahms,S.O. and Steinmetzer,T.
    The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin
    ACS Med Chem Lett (2021) 12, 426-432. PubMed  Europe PubMed DOI  PMC  EPMC  I
  50. Letarov,A.V., Babenko,V.V. and Kulikov,E.E.
    Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection
    Biochemistry (Mosc) (2021) 86, 257-261. PubMed  Europe PubMed DOI  PMC  EPMC
  51. Lewandowska-Goch,M.A., Kwiatkowska,A., Lepek,T., Ly,K., Navals,P., Gagnon,H., Dory,Y.L., Prahl,A. and Day,R.
    Design and Structure-Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin
    ACS Med Chem Lett (2021) 12, 365-372. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Lin,C., Qian,P., Zhang,Y., Liu,Z., Dai,K. and Sun,D.
    Plac1 promotes nasopharyngeal carcinoma cells proliferation, migration and invasion via Furin/NICD/PTEN pathway
    Tissue Cell (2021) 69, 101480-101480. PubMed  Europe PubMed DOI
  53. Mattila,S.O., Tuhkanen,H.E., Lackman,J.J., Konzack,A., Morato,X., Argerich,J., Saftig,P., Ciruela,F. and Petaja-Repo,U.E.
    GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin
    FASEB J (2021) 35, e21654-e21654. PubMed  Europe PubMed DOI
  54. Nejabat,M., Ghodsi,R. and Hadizadeh,F.
    Coumarins and Quinolones as Effective Multiple Targeted Agents Versus Covid-19: An in Silico Study
    Med Chem (2021) PubMed  Europe PubMed DOI
  55. Osman,E.E.A., Rehemtulla,A. and Neamati,N.
    Why All the Fury over Furin?
    J Med Chem (2021) PubMed  Europe PubMed DOI
  56. Papa,G., Mallery,D.L., Albecka,A., Welch,L.G., Cattin-Ortola,J., Luptak,J., Paul,D., McMahon,H.T., Goodfellow,I.G., Carter,A., Munro,S. and James,L.C.
    Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion
    PLoS Pathog (2021) 17, e1009246-e1009246. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Rahbar Saadat,Y., Hosseiniyan Khatibi,S.M., Zununi Vahed,S. and Ardalan,M.
    Host Serine Proteases: A Potential Targeted Therapy for COVID-19 and Influenza
    Front Mol Biosci (2021) 8, 725528-725528. PubMed  Europe PubMed DOI  PMC  EPMC  V
  58. Scagnolari,C., Bitossi,C., Viscido,A., Frasca,F., Oliveto,G., Scordio,M., Petrarca,L., Mancino,E., Nenna,R., Riva,E., De Vito,C., Midulla,F., Antonelli,G. and Pierangeli,A.
    ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry?
    Cytokine (2021) 140, 155430-155430. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Seyran,M., Takayama,K., Uversky,V.N., Lundstrom,K., Palu,G., Sherchan,S.P., Attrish,D., Rezaei,N., Aljabali,A.A.A., Ghosh,S., Pizzol,D., Chauhan,G., Adadi,P., Mohamed Abd El-Aziz,T., Soares,A.G., Kandimalla,R., Tambuwala,M., Hassan,S.S., Azad,G.K., Pal Choudhury,P., Baetas-da-Cruz,W., Serrano-Aroca,A., Brufsky,A.M. and Uhal,B.D.
    The structural basis of accelerated host cell entry by SARS-CoV-2dagger
    FEBS J (2021) 288, 5010-5020. PubMed  Europe PubMed DOI
  60. Shakya,M. and Lindberg,I.
    Mouse models of human proprotein convertase insufficiency
    Endocr Rev (2021) 42, 259-294. PubMed  Europe PubMed DOI  V
  61. Sward,P., Rosengren,B.E., Jehpsson,L. and Karlsson,M.K.
    Association between circulating furin levels, obesity and pro-inflammatory markers in children
    Acta Paediatr (2021) PubMed  Europe PubMed DOI
  62. Takeda,M.
    Proteolytic activation of SARS-CoV-2 spike protein
    Microbiol Immunol (2021) PubMed  Europe PubMed DOI  V
  63. Tang,T., Jaimes,J.A., Bidon,M.K., Straus,M.R., Daniel,S. and Whittaker,G.R.
    Proteolytic Activation of SARS-CoV-2 Spike at the S1/S2 Boundary: Potential Role of Proteases beyond Furin
    ACS Infect Dis (2021) PubMed  Europe PubMed DOI  PMC  EPMC
  64. Torre-Fuentes,L., Matias-Guiu,J., Hernandez-Lorenzo,L., Montero-Escribano,P., Pytel,V., Porta-Etessam,J., Gomez-Pinedo,U. and Matias-Guiu,J.A.
    ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain
    J Med Virol (2021) 93, 863-869. PubMed  Europe PubMed DOI  PMC  EPMC
  65. Uranaka,T., Kashio,A., Ueha,R., Sato,T., Bing,H., Ying,G., Kinoshita,M., Kondo,K. and Yamasoba,T.
    Expression of ACE2, TMPRSS2, and Furin in Mouse Ear Tissue, and the Implications for SARS-CoV-2 Infection
    Laryngoscope (2021) 131, E2013-E2017. PubMed  Europe PubMed DOI
  66. Wang,M., Xie,Y. and Qin,D.
    Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases
    Brain Res Bull (2021) 166, 172-184. PubMed  Europe PubMed DOI
  67. Wong,Y.C., Lau,S.Y., Wang To,K.K., Mok,B.W.Y., Li,X., Wang,P., Deng,S., Woo,K.F., Du,Z., Li,C., Zhou,J., Woo Chan,J.F., Yuen,K.Y., Chen,H. and Chen,Z.
    Natural transmission of bat-like SARS-CoV-2PRRA variants in COVID-19 patients
    Clin Infect Dis (2021) 73, e437-e444. PubMed  Europe PubMed DOI
  68. Yuan,Y., Raj,P., Zhang,J., Siddhanta,S., Barman,I. and Bulte,J.W.M.
    Furin-Mediated Self-Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors
    Angew Chem Int Ed Engl (2021) 60, 3923-3927. PubMed  Europe PubMed DOI
  69. Zhang,L., Mann,M., Syed,Z., Reynolds,H.M., Tian,E., Samara,N.L., Zeldin,D.C., Tabak,L.A. and Ten Hagen,K.G.
    Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation
    Proc Natl Acad Sci U S A (2021) 118, e2109905118-e2109905118. PubMed  Europe PubMed DOI  PMC  EPMC
  70. Zhang,L., Mann,M., Syed,Z.A., Reynolds,H.M., Tian,E., Samara,N.L., Zeldin,D.C., Tabak,L.A. and Ten Hagen,K.G.
    Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation
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    71. 2020
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