Literature for peptidase S08.071: furin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Bulliard,M., Pinjusic,K., Iacobucci,L., Schmuziger,C., Fournier,N. and Constam,D.B.
Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma
Nat Commun16, 2354-2354. PubMed Europe PubMed DOI K

2024

Ayyubova,G., Gychka,S.G., Nikolaienko,S.I., Alghenaim,F.A., Teramoto,T., Shults,N.V. and Suzuki,Y.J.
The Role of Furin in the Pathogenesis of COVID-19-Associated Neurological Disorders
Life (Basel)14, PubMed Europe PubMed DOI
Chauhan,P., Xue,Y., Kim,H.S., Fisher,A.L., Babitt,J.L. and Christian,J.L.
The prodomain of bone morphogenetic protein 2 promotes dimerization and cleavage of BMP6 homodimers and BMP2/6 heterodimers
J Biol Chem107790-107790. PubMed Europe PubMed DOI
Choi,A., Kots,E.D., Singleton,D.T., Weinstein,H. and Whittaker,G.R.
Analysis of the molecular determinants for furin cleavage of the spike protein S1/S2 site in defined strains of the prototype coronavirus murine hepatitis virus (MHV)
Virus Res340, 199283-199283. PubMed Europe PubMed DOI
Dicenta,V., Pelzer,A., Laspa,Z., Castor,T., Gawaz,M.P. and Rohlfing,A.K.
The subtilisin-like protease furin regulates hemin-induced CD63 surface expression on platelets
Biochem Biophys Res Commun701, 149629-149629. PubMed Europe PubMed DOI I
Fry,H., Mazidi,M., Kartsonaki,C., Clarke,R., Walters,R.G., Chen,Z. and Millwood,I.Y.
The Role of Furin and Its Therapeutic Potential in Cardiovascular Disease Risk
Int J Mol Sci25, PubMed Europe PubMed DOI V
Jiang,X., Li,D., Maghsoudloo,M., Zhang,X., Ma,W. and Fu,J.
Targeting furin, a cellular proprotein convertase, for COVID-19 prevention and therapeutics
Drug Discov Today104026-104026. PubMed Europe PubMed DOI V
Kubo,Y., Hans,M.B., Nakamura,T. and Hayashi,H.
The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site
Int J Mol Sci25, PubMed Europe PubMed DOI
Lange,R.W., Bloch,K., Heindl,M.R., Wollenhaupt,J., Weiss,M.S., Brandstetter,H., Klebe,G., Falcone,F.H., Bottcher-Friebertshauser,E., Dahms,S.O. and Steinmetzer,T.
Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors
ChemMedCheme202400057-e202400057. PubMed Europe PubMed DOI
Su,W., Ahmad,I., Wu,Y., Tang,L., Khan,I., Ye,B., Liang,J., Li,S. and Zheng,Y.H.
Furin Egress from the TGN is Regulated by Membrane-Associated RING-CH Finger (MARCHF) Proteins and Ubiquitin-Specific Protease 32 (USP32) via Nondegradable K33-Polyubiquitination
Adv Sci (Weinh)e2403732-e2403732. PubMed Europe PubMed DOI
Tanriverdi,O., Alkan,A., Karaoglu,T., Kitapli,S. and Yildiz,A.
COVID-19 and Carcinogenesis: Exploring the Hidden Links
Cureus16, e68303-e68303. PubMed Europe PubMed DOI V
Wichaiyo,S., Koonyosying,P. and Morales,N.P.
Functional Roles of Furin in Cardio-Cerebrovascular Diseases
ACS Pharmacol Transl Sci7, 570-585. PubMed Europe PubMed DOI V
Zhang,W., Shi,K., Hsueh,F.C., Mendoza,A., Ye,G., Huang,L., Perlman,S., Aihara,H. and Li,F.
Structural basis for mouse receptor recognition by bat SARS2-like coronaviruses
Proc Natl Acad Sci U S A121, e2322600121-e2322600121. PubMed Europe PubMed DOI

2023

Cendron,L., Rothenberger,S., Cassari,L., Dettin,M. and Pasquato,A.
Proprotein convertases regulate trafficking and maturation of key proteins within the secretory pathway
Adv Protein Chem Struct Biol133, 1-54. PubMed Europe PubMed DOI V
Douglas,L.E.J., Reihill,J.A., Montgomery,B.M. and Martin,S.L.
Furin as a therapeutic target in cystic fibrosis airways disease
Eur Respir Rev32, PubMed Europe PubMed DOI V
Kellnerova,S., Huber,S., Massri,M., Fleischer,V., Losso,K., Sarg,B., Kremser,L., Talasz,H., He,X., Varrone,E., Brigotti,M., Ardissino,G., Orth-Holler,D. and Wurzner,R.
Enzymatic Cleavage of Stx2a in the Gut and Identification of Pancreatic Elastase and Trypsin as Possible Main Cleavers
Microorganisms11, PubMed Europe PubMed DOI
Latini,A., De Benedittis,G., Colafrancesco,S., Perricone,C., Novelli,G., Novelli,L., Priori,R., Ciccacci,C. and Borgiani,P.
PCSK3 Overexpression in Sjogren's Syndrome Patients May Be Regulated by rs4932178 SNP in Its Promoter Region and Correlates with IFN-gamma Gene Expression
Genes (Basel)14, PubMed Europe PubMed DOI
Marafie,S.K. and Al-Mulla,F.
An Overview of the Role of Furin in Type 2 Diabetes
Cells12, PubMed Europe PubMed DOI V
Pacheco,A., Issaian,A., Davis,J., Anderson,N., Nemkov,T., Paukovich,N., Henen,M.A., Vogeli,B., Sikela,J.M. and Hansen,K.
Proteolytic activation of human-specific Olduvai domains by the furin protease
Int J Biol Macromol234, 123041-123041. PubMed Europe PubMed DOI
Xie,H., Bastepe,I., Zhou,W., Ay,B., Ceraj,Z., Portales-Castillo,I.A., Liu,E.S., Burnett-Bowie,S.M., Juppner,H., Rhee,E.P., Bastepe,M. and Simic,P.
1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage
JCI Insight8, PubMed Europe PubMed DOI

2022

Mustafa,Z., Kalbacher,H. and Burster,T.
Occurrence of a novel cleavage site for cathepsin G adjacent to the polybasic sequence within the proteolytically sensitive activation loop of the SARS-CoV-2 Omicron variant: The amino acid substitution N679K and P681H of the spike protein
PLoS ONE17, e0264723-e0264723. PubMed Europe PubMed DOI
Peng,H., Fan,Y., Li,J., Zheng,X., Zhong,C., Zhu,Z., He,Y., Zhang,M. and Zhang,Y.
DNA Methylation of the Natriuretic Peptide System Genes and Ischemic Stroke: Gene-Based and Gene Set Analyses
Neurol Genet8, e679-e679. PubMed Europe PubMed DOI
Singh,S., O'Reilly,S., Gewaid,H., Bowie,A.G., Gautier,V. and Worrall,D.M.
Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and Replication
Int J Mol Sci23, PubMed Europe PubMed DOI
Sohaei,D., Hollenberg,M., Janket,S.J., Diamandis,E.P., Poda,G. and Prassas,I.
The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology
Crit Rev Clin Lab Sci1-16. PubMed Europe PubMed DOI V
Zhang,Y., Gao,X., Bai,X., Yao,S., Chang,Y.Z. and Gao,G.
The emerging role of furin in neurodegenerative and neuropsychiatric diseases
Transl Neurodegener11, 39-39. PubMed Europe PubMed DOI V

2021

Al-Mulla,F., Mohammad,A., Al Madhoun,A., Haddad,D., Ali,H., Eaaswarkhanth,M., John,S.E., Nizam,R., Channanath,A., Abu-Farha,M., Ahmad,R., Abubaker,J. and Thanaraj,T.A.
ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19
Heliyon7, e06133-e06133. PubMed Europe PubMed DOI
Ayipo,Y.O., Yahaya,S.N., Alananzeh,W.A., Babamale,H.F. and Mordi,M.N.
Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside
Infect Genet Evol93, 104944-104944. PubMed Europe PubMed DOI V I
Berdowska,I. and Matusiewicz,M.
Cathepsin L, transmembrane peptidase/serine subfamily member 2/4, and other host proteases in COVID-19 pathogenesis - with impact on gastrointestinal tract
World J Gastroenterol27, 6590-6600. PubMed Europe PubMed DOI
Bitossi,C., Frasca,F., Viscido,A., Oliveto,G., Scordio,M., Belloni,L., Cimino,G., Pietropaolo,V., Gentile,M., d'Ettorre,G., Midulla,F., Trancassini,M., Antonelli,G., Pierangeli,A. and Scagnolari,C.
SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients
Microorganisms9, PubMed Europe PubMed DOI
Cubuk,H. and Ozbil,M.
Comparison of clinically approved molecules on SARS-CoV-2 drug target proteins: a molecular docking study
Turk J Chem45, 35-41. PubMed Europe PubMed DOI I
de Souza,A.A., de Andrade,D.M., Siqueira,F.D.S., Di Iorio,J.F., Veloso,M.P., Coelho,C.M., Viegas Junior,C., Gontijo,V.S., Dos Santos,M.H., Meneghetti,M.C.Z., Nader,H.B., Tersariol,I.L.D.S., Juliano,L., Juliano,M.A. and Judice,W.A.S.
Semysinthetic biflavonoid Morelloflavone-7,4',7'',3''',4'''-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin
Biochim Biophys Acta Gen Subj1865, 130016-130016. PubMed Europe PubMed DOI I
Dong,S., Lu,Y., Peng,G., Li,J., Li,W., Li,M., Wang,H., Liu,L. and Zhao,Q.
Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway
Dig Liver Dis PubMed Europe PubMed DOI
Gobeil,S.M., Janowska,K., McDowell,S., Mansouri,K., Parks,R., Manne,K., Stalls,V., Kopp,M.F., Henderson,R., Edwards,R.J., Haynes,B.F. and Acharya,P.
D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction
Cell Rep34, 108630-108630. PubMed Europe PubMed DOI
Graier,T., Golob-Schwarzl,N., Weger,W., Benezeder,T., Painsi,C., Salmhofer,W. and Wolf,P.
Furin Expression in Patients With Psoriasis-A Patient Cohort Endangered to SARS-COV2?
Front Med (Lausanne)8, 624462-624462. PubMed Europe PubMed DOI
Hu,X., Hai,Z., Wu,C., Zhan,W. and Liang,G.
A Golgi-Targeting and Dual-Color "Turn-On" Probe for Spatially Precise Imaging of Furin
Anal Chem93, 1636-1642. PubMed Europe PubMed DOI
Johnson,B.A., Xie,X., Bailey,A.L., Kalveram,B., Lokugamage,K.G., Muruato,A., Zou,J., Zhang,X., Juelich,T., Smith,J.K., Zhang,L., Bopp,N., Schindewolf,C., Vu,M., Vanderheiden,A., Winkler,E.S., Swetnam,D., Plante,J.A., Aguilar,P., Plante,K.S., Popov,V., Lee,B., Weaver,S.C., Suthar,M.S., Routh,A.L., Ren,P., Ku,Z., An,Z., Debbink,K., Diamond,M.S., Shi,P.Y., Freiberg,A.N. and Menachery,V.D.
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
Nature PubMed Europe PubMed DOI
Kermani,N.Z., Song,W.J., Badi,Y., Versi,A., Guo,Y., Sun,K., Bhavsar,P., Howarth,P., Dahlen,S.E., Sterk,P.J., Djukanovic,R., Adcock,I.M. and Chung,K.F.
Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma
Respir Res22, 10-10. PubMed Europe PubMed DOI
Khoury,E.E., Knaney,Y., Fokra,A., Kinaneh,S., Azzam,Z., Heyman,S.N. and Abassi,Z.
Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease
J Cell Mol Med PubMed Europe PubMed DOI
Kumar Verma,A., Kumar,V., Singh,S., Goswami,B.C., Camps,I., Sekar,A., Yoon,S. and Lee,K.W.
Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies
Biomed Pharmacother137, 111356-111356. PubMed Europe PubMed DOI I
Lam van,T.V., Heindl,M.R., Schlutt,C., Bottcher-Friebertshauser,E., Bartenschlager,R., Klebe,G., Brandstetter,H., Dahms,S.O. and Steinmetzer,T.
The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin
ACS Med Chem Lett12, 426-432. PubMed Europe PubMed DOI I
Letarov,A.V., Babenko,V.V. and Kulikov,E.E.
Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection
Biochemistry (Mosc)86, 257-261. PubMed Europe PubMed DOI
Lewandowska-Goch,M.A., Kwiatkowska,A., Lepek,T., Ly,K., Navals,P., Gagnon,H., Dory,Y.L., Prahl,A. and Day,R.
Design and Structure-Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin
ACS Med Chem Lett12, 365-372. PubMed Europe PubMed DOI
Lin,C., Qian,P., Zhang,Y., Liu,Z., Dai,K. and Sun,D.
Plac1 promotes nasopharyngeal carcinoma cells proliferation, migration and invasion via Furin/NICD/PTEN pathway
Tissue Cell69, 101480-101480. PubMed Europe PubMed DOI
Mattila,S.O., Tuhkanen,H.E., Lackman,J.J., Konzack,A., Morato,X., Argerich,J., Saftig,P., Ciruela,F. and Petaja-Repo,U.E.
GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin
FASEB J35, e21654-e21654. PubMed Europe PubMed DOI
Nejabat,M., Ghodsi,R. and Hadizadeh,F.
Coumarins and Quinolones as Effective Multiple Targeted Agents Versus Covid-19: An in Silico Study
Med Chem PubMed Europe PubMed DOI
Osman,E.E.A., Rehemtulla,A. and Neamati,N.
Why All the Fury over Furin?
J Med Chem PubMed Europe PubMed DOI
Papa,G., Mallery,D.L., Albecka,A., Welch,L.G., Cattin-Ortola,J., Luptak,J., Paul,D., McMahon,H.T., Goodfellow,I.G., Carter,A., Munro,S. and James,L.C.
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion
PLoS Pathog17, e1009246-e1009246. PubMed Europe PubMed DOI
Rahbar Saadat,Y., Hosseiniyan Khatibi,S.M., Zununi Vahed,S. and Ardalan,M.
Host Serine Proteases: A Potential Targeted Therapy for COVID-19 and Influenza
Front Mol Biosci8, 725528-725528. PubMed Europe PubMed DOI V
Scagnolari,C., Bitossi,C., Viscido,A., Frasca,F., Oliveto,G., Scordio,M., Petrarca,L., Mancino,E., Nenna,R., Riva,E., De Vito,C., Midulla,F., Antonelli,G. and Pierangeli,A.
ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry?
Cytokine140, 155430-155430. PubMed Europe PubMed DOI
Seyran,M., Takayama,K., Uversky,V.N., Lundstrom,K., Palu,G., Sherchan,S.P., Attrish,D., Rezaei,N., Aljabali,A.A.A., Ghosh,S., Pizzol,D., Chauhan,G., Adadi,P., Mohamed Abd El-Aziz,T., Soares,A.G., Kandimalla,R., Tambuwala,M., Hassan,S.S., Azad,G.K., Pal Choudhury,P., Baetas-da-Cruz,W., Serrano-Aroca,A., Brufsky,A.M. and Uhal,B.D.
The structural basis of accelerated host cell entry by SARS-CoV-2dagger
FEBS J288, 5010-5020. PubMed Europe PubMed DOI
Shakya,M. and Lindberg,I.
Mouse models of human proprotein convertase insufficiency
Endocr Rev42, 259-294. PubMed Europe PubMed DOI V
Sward,P., Rosengren,B.E., Jehpsson,L. and Karlsson,M.K.
Association between circulating furin levels, obesity and pro-inflammatory markers in children
Acta Paediatr PubMed Europe PubMed DOI
Takeda,M.
Proteolytic activation of SARS-CoV-2 spike protein
Microbiol Immunol PubMed Europe PubMed DOI V
Tang,T., Jaimes,J.A., Bidon,M.K., Straus,M.R., Daniel,S. and Whittaker,G.R.
Proteolytic Activation of SARS-CoV-2 Spike at the S1/S2 Boundary: Potential Role of Proteases beyond Furin
ACS Infect Dis PubMed Europe PubMed DOI
Torre-Fuentes,L., Matias-Guiu,J., Hernandez-Lorenzo,L., Montero-Escribano,P., Pytel,V., Porta-Etessam,J., Gomez-Pinedo,U. and Matias-Guiu,J.A.
ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain
J Med Virol93, 863-869. PubMed Europe PubMed DOI
Uranaka,T., Kashio,A., Ueha,R., Sato,T., Bing,H., Ying,G., Kinoshita,M., Kondo,K. and Yamasoba,T.
Expression of ACE2, TMPRSS2, and Furin in Mouse Ear Tissue, and the Implications for SARS-CoV-2 Infection
Laryngoscope131, E2013-E2017. PubMed Europe PubMed DOI
Wang,M., Xie,Y. and Qin,D.
Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases
Brain Res Bull166, 172-184. PubMed Europe PubMed DOI
Wong,Y.C., Lau,S.Y., Wang To,K.K., Mok,B.W.Y., Li,X., Wang,P., Deng,S., Woo,K.F., Du,Z., Li,C., Zhou,J., Woo Chan,J.F., Yuen,K.Y., Chen,H. and Chen,Z.
Natural transmission of bat-like SARS-CoV-2PRRA variants in COVID-19 patients
Clin Infect Dis73, e437-e444. PubMed Europe PubMed DOI
Yuan,Y., Raj,P., Zhang,J., Siddhanta,S., Barman,I. and Bulte,J.W.M.
Furin-Mediated Self-Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors
Angew Chem Int Ed Engl60, 3923-3927. PubMed Europe PubMed DOI
Zhang,L., Mann,M., Syed,Z.A., Reynolds,H.M., Tian,E., Samara,N.L., Zeldin,D.C., Tabak,L.A. and Ten Hagen,K.G.
Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation
Proc Natl Acad Sci U S A118, PubMed Europe PubMed DOI
Zhang,L., Mann,M., Syed,Z., Reynolds,H.M., Tian,E., Samara,N.L., Zeldin,D.C., Tabak,L.A. and Ten Hagen,K.G.
Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation
Proc Natl Acad Sci U S A118, e2109905118-e2109905118. PubMed Europe PubMed DOI

2020

AbdelMassih,A.F., Ye,J., Kamel,A., Mishriky,F., Ismail,H.A., Ragab,H.A., El Qadi,L., Malak,L., Abdu,M., El-Husseiny,M., Ashraf,M., Hafez,N., AlShehry,N., El-Husseiny,N., AbdelRaouf,N., Shebl,N., Hafez,N., Youssef,N., Afdal,P., Hozaien,R., Menshawey,R., Saeed,R. and Fouda,R.
A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection
Obes Med19, 100281-100281. PubMed Europe PubMed DOI I
Acosta-Elias,J. and Espinosa-Tanguma,R.
The Folate Concentration and/or Folic Acid Metabolites in Plasma as Factor for COVID-19 Infection
Front Pharmacol11, 1062-1062. PubMed Europe PubMed DOI
Adu-Agyeiwaah,Y., Grant,M.B. and Obukhov,A.G.
The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes
Cells9, PubMed Europe PubMed DOI
Anand,P., Puranik,A., Aravamudan,M., Venkatakrishnan,A.J. and Soundararajan,V.
SARS-CoV-2 strategically mimics proteolytic activation of human ENaC
elife9, PubMed Europe PubMed DOI
Bai,L., Chang,H.M., Zhang,L., Zhu,Y.M. and Leung,P.C.K.
BMP2 increases the production of BDNF through the upregulation of proBDNF and furin expression in human granulosa-lutein cells
FASEB J PubMed Europe PubMed DOI
Bestle,D., Heindl,M.R., Limburg,H., Van Lam van,T., Pilgram,O., Moulton,H., Stein,D.A., Hardes,K., Eickmann,M., Dolnik,O., Rohde,C., Klenk,H.D., Garten,W., Steinmetzer,T. and Bottcher-Friebertshauser,E.
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
Life Sci Alliance3, PubMed Europe PubMed DOI
Brooke,G.N. and Prischi,F.
Structural and functional modelling of SARS-CoV-2 entry in animal models
Sci Rep10, 15917-15917. PubMed Europe PubMed DOI
Brouwers,B., Coppola,I., Vints,K., Dislich,B., Jouvet,N., Van Lommel,L., Segers,C., Gounko,N.V., Thorrez,L., Schuit,F., Lichtenthaler,S.F., Estall,J.L., Declercq,J., Ramos-Molina,B. and Creemers,J.W.M.
Loss of Furin in beta cells Induces an mTORC1-ATF4 Anabolic Pathway that Leads to beta cell Dysfunction
Diabetes PubMed Europe PubMed DOI
Cao,R., Zhang,Y., Du,J., Chen,S., Wang,N., Ying,H. and Shen,B.
Increased FURIN expression in rheumatoid arthritis patients and its anti-inflammatory effect
J Clin Lab Anale23530-e23530. PubMed Europe PubMed DOI
Chambers,J.P., Yu,J., Valdes,J.J. and Arulanandam,B.P.
SARS-CoV-2, Early Entry Events
J Pathog2020, 9238696-9238696. PubMed Europe PubMed DOI
Chen,Y., Guo,M., QU,D., Liu,Y., Guo,J. and Chen,Y.
Furin-responsive triterpenine-based liposomal complex enhances anticervical cancer therapy through size modulation
Drug Deliv27, 1608-1624. PubMed Europe PubMed DOI
Chowdhury,T., Roymahapatra,G. and Mandal,S.M.
In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2: Inhibitor of RNA Dependent RNA polymerase (RdRp) and Essential Proteases
Infect Disord Drug Targets PubMed Europe PubMed DOI
Davidson,A.D., Williamson,M.K., Lewis,S., Shoemark,D., Carroll,M.W., Heesom,K.J., Zambon,M., Ellis,J., Lewis,P.A., Hiscox,J.A. and Matthews,D.A.
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein
Genome Med12, 68-68. PubMed Europe PubMed DOI
Fitzgerald,K.
Furin Protease: From SARS CoV-2 to Anthrax, Diabetes, and Hypertension
Perm J24, PubMed Europe PubMed DOI
Gaunkar,R.B., Nagarsekar,A., Carvalho,K.M., Jodalli,P.S. and Mascarenhas,K.
COVID-19 in Smokeless Tobacco Habitues: Increased Susceptibility and Transmission
Cureus12, e8824-e8824. PubMed Europe PubMed DOI
Ge,J., Zhang,S., Zhang,L. and Wang,X.
Structural basis of severe acute respiratory syndrome coronavirus 2 infection
Curr Opin HIV AIDS PubMed Europe PubMed DOI V
Gioia,M., Ciaccio,C., Calligari,P., De Simone,G., Sbardella,D., Tundo,G., Fasciglione,G.F., di Masi,A., Di Pierro,D., Bocedi,A., Ascenzi,P. and Coletta,M.
Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches
Biochem Pharmacol182, 114225-114225. PubMed Europe PubMed DOI V
Gou,X., Xue,Y., Zheng,H., Yang,G., Chen,S., Chen,Z. and Yuan,G.
Gelatinases Cleave Dentin Sialoprotein Intracellularly
Front Physiol11, 686-686. PubMed Europe PubMed DOI L
He,Z., Khatib,A.M. and Creemers,J.W.M.
Loss of the proprotein convertase furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer
Cancer Lett484, 40-49. PubMed Europe PubMed DOI T
He,Z., Thorrez,L., Siegfried,G., Meulemans,S., Evrard,S., Tejpar,S., Khatib,A.M. and Creemers,J.W.M.
The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer
Oncogene39, 3571-3587. PubMed Europe PubMed DOI
Hoffmann,M., Kleine-Weber,H. and Pohlmann,S.
A multibasic cleavage site in the spike protein of SARS-CoV-2 is essential for infection of human lung cells
Mol Cell78, 779-784. PubMed Europe PubMed DOI
Jaimes,J., Millet,J. and Whittaker,G.
Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site
SSRN3581359-3581359. PubMed Europe PubMed DOI
Jin,X., Xu,K., Jiang,P., Lian,J., Hao,S., Yao,H., Jia,H., Zhang,Y., Zheng,L., Zheng,N., Chen,D., Yao,J., Hu,J., Gao,J., Wen,L., Shen,J., Ren,Y., Yu,G., Wang,X., Lu,Y., Yu,X., Yu,L., Xiang,D., Wu,N., Lu,X., Cheng,L., Liu,F., Wu,H., Jin,C., Yang,X., Qian,P., Qiu,Y., Sheng,J., Liang,T., Li,L. and Yang,Y.
Virus strain from a mild COVID-19 patient in Hangzhou represents a new trend in SARS-CoV-2 evolution potentially related to Furin cleavage site
Emerg Microbes Infect9, 1474-1488. PubMed Europe PubMed DOI
Johnson,B.A., Xie,X., Kalveram,B., Lokugamage,K.G., Muruato,A., Zou,J., Zhang,X., Juelich,T., Smith,J.K., Zhang,L., Bopp,N., Schindewolf,C., Vu,M., Vanderheiden,A., Swetnam,D., Plante,J.A., Aguilar,P., Plante,K.S., Lee,B., Weaver,S.C., Suthar,M.S., Routh,A.L., Ren,P., Ku,Z., An,Z., Debbink,K., Shi,P.Y., Freiberg,A.N. and Menachery,V.D.
Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis
bioRxiv PubMed Europe PubMed DOI
Ke,J.Y., Yang,J., Li,J., Xu,Z., Li,M.Q. and Zhu,Z.L.
Baicalein inhibits FURIN-MT1-MMP-mediated invasion of ectopic endometrial stromal cells in endometriosis possibly by reducing the secretion of TGFB1
Am J Reprod Immunole13344-e13344. PubMed Europe PubMed DOI
Klaassen,K., Stankovic,B., Zukic,B., Kotur,N., Gasic,V., Pavlovic,S. and Stojiljkovic,M.
Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infection
Infect Genet Evol84, 104498-104498. PubMed Europe PubMed DOI
Klimstra,W.B., Tilston-Lunel,N.L., Nambulli,S., Boslett,J., McMillen,C.M., Gilliland,T., Dunn,M.D., Sun,C., Wheeler,S.E., Wells,A., Hartman,A.L., McElroy,A.K., Reed,D.S., Rennick,L.J. and Duprex,W.P.
SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients
bioRxiv PubMed Europe PubMed DOI
Kropp,K.A., Srivaratharajan,S., Ritter,B., Yu,P., Krooss,S., Polten,F., Pich,A., Alcami,A. and Viejo-Borbolla,A.
Identification of the Cleavage Domain within Glycoprotein G of Herpes Simplex Virus Type 2
Viruses12, DOI
Li,W.
Delving deep into the structural aspects of a furin cleavage site inserted into the spike protein of SARS-CoV-2: A structural biophysical perspective
Biophys Chem264, 106420-106420. PubMed Europe PubMed DOI
Liu,H., Gai,S., Wang,X., Zeng,J., Sun,C., Zhao,Y. and Zheng,Z.
Single-cell analysis of SARS-CoV-2 receptor ACE2 and spike protein priming expression of proteases in the human heart
Cardiovasc Res116, 1733-1741. PubMed Europe PubMed DOI
Manikyam,H.K. and Joshi,S.K.
Whole Genome Analysis and Targeted Drug Discovery Using Computational Methods and High Throughput Screening Tools for Emerged Novel Coronavirus (2019-nCoV)
J Pharm Drug Res3, 341-361. PubMed Europe PubMed I
Maremanda,K.P., Sundar,I.K., Li,D. and Rahman,I.
Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis
Res Sq PubMed Europe PubMed DOI
Ming,Y. and Qiang,L.
Involvement of Spike Protein, Furin, and ACE2 in SARS-CoV-2-Related Cardiovascular Complications
SN Compr Clin Med1-6. PubMed Europe PubMed DOI
Mohammad,A., Alshawaf,E., Marafie,S.K., Abu-Farha,M., Abubaker,J. and Al-Mulla,F.
Higher binding affinity of Furin to SARS-CoV-2 spike (S) protein D614G could be associated with higher SARS-CoV-2 infectivity
Int J Infect Dis PubMed Europe PubMed DOI
Mori,T., Koyama,N., Yokoo,T., Segawa,T., Maeda,M., Sawmiller,D., Tan,J. and Town,T.
Gallic Acid is a Dual alpha/beta-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice
J Biol Chem PubMed Europe PubMed DOI
Muhanna,D., Arnipalli,S.R., Kumar,S.B. and Ziouzenkova,O.
Osmotic Adaptation by Na(+)-Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19
Biomedicines8, PubMed Europe PubMed DOI V
Nguyen,H.T., Zhang,S., Wang,Q., Anang,S., Wang,J., Ding,H., Kappes,J.C. and Sodroski,J.
Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effects
J Virol PubMed Europe PubMed DOI
O'Sullivan,M.J., Mitchel,J.A., Mwase,C., McGill,M., Kanki,P. and Park,J.A.
In well-differentiated primary human bronchial epithelial cells, TGF-beta1 and TGF-beta2 induce expression of furin
Am J Physiol Lung Cell Mol Physiol PubMed Europe PubMed DOI
Oleaga,C., Hay,J., Gurcan,E., David,L.L., Mueller,P.A., Tavori,H., Shapiro,M.D., Pamir,N. and Fazio,S.
Insights on the kinetics and dynamics of the furin-cleaved form of PCSK9
J Lipid Res PubMed Europe PubMed DOI
Ord,M., Faustova,I. and Loog,M.
The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV
Sci Rep10, 16944-16944. PubMed Europe PubMed DOI
Palit,P., Chattopadhyay,D., Thomas,S., Kundu,A., Kim,H.S. and Rezaei,N.
Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?
Phytomedicine153396-153396. PubMed Europe PubMed DOI
Paria,K., Paul,D., Chowdhury,T., Pyne,S., Chakraborty,R. and Mandal,S.M.
Synergy of melanin and vitamin-D may play a fundamental role in preventing SARS-CoV-2 infections and halt COVID-19 by inactivating furin protease
Transl Med Commun5, 21-21. PubMed Europe PubMed DOI
Ragia,G. and Manolopoulos,V.G.
Assessing COVID-19 susceptibility through analysis of the genetic and epigenetic diversity of ACE2 mediated SARS-CoV-2 entry
Pharmacogenomics PubMed Europe PubMed DOI
Ren,L., Chen,Y., Zhang,Q., Zhang,M., Yu,J., He,Y. and Peng,H.
A higher level of serum furin indicates a higher risk of microalbuminuria: results from a longitudinal study in Chinese adults
Clin Exp Nephrol PubMed Europe PubMed DOI
Sakaguchi,W., Kubota,N., Shimizu,T., Saruta,J., Fuchida,S., Kawata,A., Yamamoto,Y., Sugimoto,M., Yakeishi,M. and Tsukinoki,K.
Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity
Int J Mol Sci21, PubMed Europe PubMed DOI
Segreto,R. and Deigin,Y.
The genetic structure of SARS-CoV-2 does not rule out a laboratory origin: SARS-COV-2 chimeric structure and furin cleavage site might be the result of genetic manipulation
Bioessayse2000240-e2000240. PubMed Europe PubMed DOI
Stanton,B.A., Hampton,T.H. and Ashare,A.
SARS-CoV-2 (COVID-19) and Cystic Fibrosis
Am J Physiol Lung Cell Mol Physiol319, L408-L415. PubMed Europe PubMed DOI
Vankadari,N.
Structure of Furin Protease Binding to SARS-CoV-2 Spike Glycoprotein and Implications for Potential Targets and Virulence
J Phys Chem Lett11, 6655-6663. PubMed Europe PubMed DOI
Varma,P., Lybrand,Z.R., Antopia,M.C. and Hsieh,J.
Novel Targets of SARS-CoV-2 Spike Protein in Human Fetal Brain Development Suggest Early Pregnancy Vulnerability
Front Neurosci14, 614680-614680. PubMed Europe PubMed DOI
Wang,H., Li,J., He,J., Liu,Y., Feng,W., Zhou,H., Zhou,M., Wei,H., Lu,Y., Peng,W., Du,F., Gong,A. and Xu,M.
Methyl-CpG-binding protein 2 drives the Furin/TGF-beta1/Smad axis to promote epithelial-mesenchymal transition in pancreatic cancer cells
Oncogenesis9, 76-76. PubMed Europe PubMed DOI
Wang,Q., Qiu,Y., Li,J.Y., Zhou,Z.J., Liao,C.H. and Ge,X.Y.
A unique protease cleavage site predicted in the spike protein of the novel pneumonia coronavirus (2019-nCoV) potentially related to viral transmissibility
Virol Sin35, 337-339. PubMed Europe PubMed DOI
Wang,Y.K., Tang,J.N., Han,L., Liu,X.D., Shen,Y.L., Zhang,C.Y. and Liu,X.B.
Elevated FURIN levels in predicting mortality and cardiovascular events in patients with acute myocardial infarction
Metabolism154323-154323. PubMed Europe PubMed DOI
Wrobel,A.G., Benton,D.J., Xu,P., Roustan,C., Martin,S.R., Rosenthal,P.B., Skehel,J.J. and Gamblin,S.J.
Author Correction: SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects
Nat Struct Mol Biol27, 1001-1001. PubMed Europe PubMed DOI
Wrobel,A.G., Benton,D.J., Xu,P., Roustan,C., Martin,S.R., Rosenthal,P.B., Skehel,J.J. and Gamblin,S.J.
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects
Nat Struct Mol Biol27, 763-767. PubMed Europe PubMed DOI
Wu,C., Zheng,M., Yang,Y., Gu,X., Yang,K., Li,M., Liu,Y., Zhang,Q., Zhang,P., Wang,Y., Wang,Q., Xu,Y., Zhou,Y., Zhang,Y., Chen,L. and Li,H.
Furin: A Potential Therapeutic Target for COVID-19
iScience23, 101642-101642. PubMed Europe PubMed DOI
Wu,Y. and Zhao,S.
Furin cleavage sites naturally occur in coronaviruses
Stem Cell Res50, 102115-102115. PubMed Europe PubMed DOI
Xia,S., Lan,Q., Su,S., Wang,X., Xu,W., Liu,Z., Zhu,Y., Wang,Q., Lu,L. and Jiang,S.
The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin
Signal Transduct Target Ther5, 92-92. PubMed Europe PubMed DOI
Xing,Y., Li,X., Gao,X. and Dong,Q.
Natural Polymorphisms Are Present in the Furin Cleavage Site of the SARS-CoV-2 Spike Glycoprotein
Front Genet11, 783-783. PubMed Europe PubMed DOI
Yu,C., Li,S., Zhang,X., Khan,I., Ahmad,I., Zhou,Y., Li,S., Shi,J., Wang,Y. and Zheng,Y.H.
MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation
MBio11, PubMed Europe PubMed DOI
Zhao,X., Chen,D., Szabla,R., Zheng,M., Li,G., Du,P., Zheng,S., Li,X., Song,C., Li,R., Guo,J.T., Junop,M., Zeng,H. and Lin,H.
Broad and differential animal ACE2 receptor usage by SARS-CoV-2
J Virol94, e00940-20-e00940-20. PubMed Europe PubMed DOI
Zhong,M., Lin,B., Pathak,J.L., Gao,H., Young,A.J., Wang,X., Liu,C., Wu,K., Liu,M., Chen,J.M., Huang,J., Lee,L.H., Qi,C.L., Ge,L. and Wang,L.
ACE2 and Furin Expressions in Oral Epithelial Cells Possibly Facilitate COVID-19 Infection via Respiratory and Fecal-Oral Routes
Front Med (Lausanne)7, 580796-580796. PubMed Europe PubMed DOI
Zhou,L., Niu,Z., Jiang,X., Zhang,Z., Zheng,Y., Wang,Z., Zhu,Y., Gao,L., Huang,H., Wang,X. and Sun,Q.
SARS-CoV-2 Targets by the pscRNA Profiling of ACE2, TMPRSS2 and Furin Proteases
iScience23, 101744-101744. PubMed Europe PubMed DOI
Zupin,L., Pascolo,L. and Crovella,S.
Is FURIN gene expression in salivary glands related to SARS-CoV-2 infectivity through saliva?
J Clin Pathol74, 209-211. PubMed Europe PubMed DOI

2019

Braun,E. and Sauter,D.
Furin-mediated protein processing in infectious diseases and cancer
Clin Transl Immunology8, e1073-e1073. PubMed Europe PubMed DOI V
Cao,C., Sheng,D., Li,X., Xue,F., Liu,L., Zhong,Y., Wei,P., Li,R. and Yi,T.
Furin substrate as a novel cell-penetrating peptide: combining a delivery vector and an inducer of cargo release
Chem Commun (Camb)55, 11872-11875. PubMed Europe PubMed DOI
Cheong,H., Kim,J., Mu,J., Zhang,W., Li,J., Yang,H. and Xing,B.
Spatiotemporal-controlled reporter for cell-surface proteolytic enzyme activity visualization
Chembiochem20, 561-567. PubMed Europe PubMed DOI L
Cilhoroz,B.T., Schifano,E.D., Panza,G.A., Ash,G.I., Corso,L., Chen,M.H., Deshpande,V., Zaleski,A., Farinatti,P., Santos,L.P., Taylor,B.A., O'Neill,R.J., Thompson,P.D. and Pescatello,L.S.
FURIN variant associations with postexercise hypotension are intensity and race dependent
Physiol Rep7, e13952-e13952. PubMed Europe PubMed DOI M
Jaimes,J.A., Millet,J.K., Goldstein,M.E., Whittaker,G.R. and Straus,M.R.
A fluorogenic peptide cleavage assay to screen for proteolytic activity: applications for coronavirus spike protein activation
J Vis Exp PubMed Europe PubMed DOI A
Low,K., Hardes,K., Fedeli,C., Seidah,N.G., Constam,D.B., Pasquato,A., Steinmetzer,T., Roulin,A. and Kunz,S.
A novel cell-based sensor detecting the activity of individual basic proprotein convertases
FEBS J286, 4597-4620. PubMed Europe PubMed DOI A
Mamedov,T., Musayeva,I., Acsora,R., Gun,N., Gulec,B., Mammadova,G., Cicek,K. and Hasanova,G.
Engineering, and production of functionally active human furin in N. benthamiana plant: in vivo post-translational processing of target proteins by furin in plants
PLoS ONE14, e0213438-e0213438. PubMed Europe PubMed DOI E
Pearce,K.H., Overton,L.K., Gampe,R.T., Barrett,G.B., Taylor,J.D., McKee,D.D., Campobasso,N., Nolte,R.T. and Reid,R.A.
BacMam production and crystal structure of nonglycosylated apo human furin at 1.89 A resolution
Acta Crystallogr F Struct Biol Commun75, 239-245. PubMed Europe PubMed DOI E S
Sachan,V., Lodge,R., Mihara,K., Hamelin,J., Power,C., Gelman,B.B., Hollenberg,M.D., Cohen,E.A. and Seidah,N.G.
HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by furin
Cell Death Differ26, 1942-1954. PubMed Europe PubMed DOI
Shin,K., Landsman,M., Pelletier,S., Alamri,B.N., Anini,Y. and Rainey,J.K.
Proapelin is processed extracellularly in a cell line-dependent manner with clear modulation by proprotein convertases
Amino Acids51, 395-405. PubMed Europe PubMed DOI
Sun,S., Liu,Y., Xia,J., Wang,M., Tang,R., Lei,C., Huang,Y., Nie,Z. and Yao,S.
A semisynthetic fluorescent protein assembly-based FRET probe for real-time profiling of cell membrane protease functions in situ
Chem Commun (Camb)55, 2218-2221. PubMed Europe PubMed DOI L
Van Lam van,T., Ivanova,T., Hardes,K., Heindl,M.R., Morty,R.E., Bottcher-Friebertshauser,E., Lindberg,I., Than,M.E., Dahms,S.O. and Steinmetzer,T.
Design, synthesis, and characterization of macrocyclic inhibitors of the proprotein convertase furin
ChemMedChem14, 673-685. PubMed Europe PubMed DOI I
Wang,H., Chen,P., Wu,H., Zou,P., Wu,J., Liu,Y. and Liang,G.
Furin-guided intracellular (68)Ga nanoparticle formation enhancing tumor microPET imaging
Anal Chem91, 14842-14845. PubMed Europe PubMed DOI L
Yakala,G.K., Cabrera-Fuentes,H.A., Crespo-Avilan,G.E., Rattanasopa,C., Burlacu,A., George,B.L., Anand,K., Mayan,D.C., Corliano,M., Hernandez-Resendiz,S., Wu,Z., Schwerk,A.M.K., Tan,A.L.J., Trigueros-Motos,L., Chevre,R., Chua,T., Kleemann,R., Liehn,E.A., Hausenloy,D.J., Ghosh,S. and Singaraja,R.R.
Furin inhibition reduces vascular remodeling and atherosclerotic lesion progression in mice
Arterioscler Thromb Vasc Biol39, 387-401. PubMed Europe PubMed DOI
Yuan,Y., Zhang,J., Qi,X., Li,S., Liu,G., Siddhanta,S., Barman,I., Song,X., McMahon,M.T. and Bulte,J.W.M.
Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced magnetic resonance imaging and tumour therapy
Nat Mater18, 1376-1383. PubMed Europe PubMed DOI
Zhu,L., Liu,H.W., Yang,Y., Hu,X.X., Li,K., Xu,S., Li,J.B., Ke,G. and Zhang,X.B.
Near-infrared fluorescent furin probe for revealing the role of furin in cellular carcinogenesis and specific cancer imaging
Anal Chem91, 9682-9689. PubMed Europe PubMed DOI A L

2018

Dahms,S.O., Hardes,K., Steinmetzer,T. and Than,M.E.
X-ray structures of the proprotein convertase furin bound with substrate analogue inhibitors reveal substrate specificity determinants beyond the S4 pocket
Biochemistry57, 925-934. PubMed Europe PubMed DOI P S
Hai,Z., Wu,J., Saimi,D., Ni,Y., Zhou,R. and Liang,G.
Smart dual quenching strategy enhances the detection sensitivity of intracellular furin
Anal Chem90, 1520-1524. PubMed Europe PubMed DOI L
Hasegawa-Minato,J., Toyoshima,M., Ishibashi,M., Zhang,X., Shigeta,S., Grandori,C., Kitatani,K. and Yaegashi,N.
Novel cooperative pathway of c-Myc and furin, a pro-protein convertase, in cell proliferation as a therapeutic target in ovarian cancers
Oncotarget9, 3483-3496. PubMed Europe PubMed DOI
Huang,Y., Long,Y., Li,S., Lin,T., Wu,J., Zhang,Y. and Lin,Y.
Investigation on the processing and improving the cleavage efficiency of furin cleavage sites in Pichia pastoris
Microb Cell Fact17, 172-172. PubMed Europe PubMed DOI
Li,J.J., Liu,J., Lupino,K., Liu,X., Zhang,L. and Pei,L.
Growth Differentiation Factor 15 maturation requires proteolytic cleavage by PCSK3, 5 and 6
Mol Cell Biol38, e00249-18-e00249-18. PubMed Europe PubMed DOI
Li,K., Hu,X.X., Liu,H.W., Xu,S., Huan,S.Y., Li,J.B., Deng,T.G. and Zhang,X.B.
In situ imaging of furin activity with a highly stable probe by releasing of precipitating fluorochrome
Anal Chem90, 11680-11687. PubMed Europe PubMed DOI L
Taylor,J., Unsoeld,T. and Hutter,H.
The transmembrane collagen COL-99 guides longitudinally extending axons in C. elegans
Mol Cell Neurosci89, 9-19. PubMed Europe PubMed DOI
Yang,Y., He,M., Tian,X., Guo,Y., Liu,F., Li,Y., Zhang,H., Lu,X., Xu,D., Zhou,R., Ma,Y., Wang,W., Chen,G., Hu,Y. and Wang,X.
Transgenic overexpression of furin increases epileptic susceptibility
Cell Death Dis9, 1058-1058. PubMed Europe PubMed DOI
Zhao,X., Lv,G., Peng,Y., Liu,Q., Li,X., Wang,S., Li,K., Qiu,L. and Lin,J.
Targeted delivery of an activatable fluorescent probe for the detection of furin activity in living cells
Chembiochem19, 1060-1065. PubMed Europe PubMed DOI L
Zhu,B., Zhao,L., Luo,D., Xu,D., Tan,T., Dong,Z., Tang,Y., Min,Z., Deng,X., Sun,F., Yan,Z. and Chen,G.
Furin promotes dendritic morphogenesis and learning and memory in transgenic mice
Cell Mol Life Sci75, 2473-2488. PubMed Europe PubMed DOI

2017

Al Rifai,O., Chow,J., Lacombe,J., Julien,C., Faubert,D., Susan-Resiga,D., Essalmani,R., Creemers,J.W., Seidah,N.G. and Ferron,M.
Proprotein convertase furin regulates osteocalcin and bone endocrine function
J Clin Invest127, 4104-4117. PubMed Europe PubMed DOI
Bassi,D.E., Zhang,J., Renner,C. and Klein-Szanto,A.J.
Targeting proprotein convertases in furin-rich lung cancer cells results in decreased in vitro and in vivo growth
Mol Carcinog56, 1182-1188. PubMed Europe PubMed DOI T I
Dahms,S.O., Jiao,G.S. and Than,M.E.
Structural studies revealed active site distortions of human furin by a small molecule inhibitor
ACS Chem Biol12, 1211-1216. PubMed Europe PubMed DOI S I
Hardes,K., Ivanova,T., Thaa,B., McInerney,G.M., Klokk,T.I., Sandvig,K., Kunzel,S., Lindberg,I. and Steinmetzer,T.
Elongated and shortened peptidomimetic inhibitors of the proprotein convertase furin
ChemMedChem12, 613-620. PubMed Europe PubMed DOI I
Ivanova,T., Hardes,K., Kallis,S., Dahms,S.O., Than,M.E., Kunzel,S., Bottcher-Friebertshauser,E., Lindberg,I., Jiao,G.S., Bartenschlager,R. and Steinmetzer,T.
Optimization of substrate-analogue furin inhibitors
ChemMedChem12, 1953-1968. PubMed Europe PubMed DOI I
Nakagawa,T., Suzuki-Nakagawa,C., Watanabe,A., Asami,E., Matsumoto,M., Nakano,M., Ebihara,A., Uddin,M.N. and Suzuki,F.
Site-1 protease is required for the generation of soluble (pro)renin receptor
J Biochem161, 369-379. PubMed Europe PubMed DOI I
Yao,D., Zhao,W., Zhang,L. and Tian,Y.
A ratiometric electrochemical strategy for sensitive determination of furin activity based on dual signal amplification and antifouling nanosurfaces
Analyst142, 4215-4220. PubMed Europe PubMed DOI A
Zhang,Y., Zhou,M., Wei,H., Zhou,H., He,J., Lu,Y., Wang,D., Chen,B., Zeng,J., Peng,W., Du,F., Gong,A. and Xu,M.
Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells via Hippo-YAP pathway
Int J Oncol50, 1352-1362. PubMed Europe PubMed DOI I

2016

Bronnimann,M.P., Calton,C.M., Chiquette,S.F., Li,S., Lu,M., Chapman,J.A., Bratton,K.N., Schlegel,A.M. and Campos,S.K.
Furin cleavage of L2 during papillomavirus infection: minimal dependence on cyclophilins
J Virol90, 6224-6234. PubMed Europe PubMed DOI
Cordova,Z.M., Gronholm,A., Kytola,V., Taverniti,V., Hamalainen,S., Aittomaki,S., Niininen,W., Junttila,I., Ylipaa,A., Nykter,M. and Pesu,M.
Myeloid cell expressed proprotein convertase FURIN attenuates inflammation
Oncotarget7, 54392-54404. PubMed Europe PubMed DOI K
Dahms,S.O., Arciniega,M., Steinmetzer,T., Huber,R. and Than,M.E.
Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism
Proc Natl Acad Sci U S A113, 11196-11201. PubMed Europe PubMed DOI S
Demasi,M.A., de S Molina,E., Bowman-Colin,C., Lojudice,F.H., Muras,A. and Sogayar,M.C.
Enhanced proteolytic processing of recombinant human coagulation factor VIII B-domain variants by recombinant furins
Mol Biotechnol58, 404-414. PubMed Europe PubMed DOI
Ferguson,T.E., Reihill,J.A., Walker,B., Hamilton,R.A. and Martin,S.L.
A selective irreversible inhibitor of furin does not prevent Pseudomonas aeruginosa exotoxin A-induced airway epithelial cytotoxicity
PLoS ONE11, e0159868-e0159868. PubMed Europe PubMed DOI I
Jaaks,P., Meier,G., Alijaj,N., Brack,E., Bode,P., Koscielniak,E., Wachtel,M., Schafer,B.W. and Bernasconi,M.
The proprotein convertase furin is required to maintain viability of alveolar rhabdomyosarcoma cells
Oncotarget7, 76743-76755. PubMed Europe PubMed DOI
Jaaks,P., D'Alessandro,V., Grob,N., Buel,S., Hajdin,K., Schafer,B.W. and Bernasconi,M.
The proprotein convertase furin contributes to rhabdomyosarcoma malignancy by promoting vascularization, migration and invasion
PLoS ONE11, e0161396-e0161396. PubMed Europe PubMed DOI
Osadchuk,T.V., Shybyryn,O.V. and Kibirev,V.K.
Chemical structure and properties of low-molecular furin inhibitors
Ukr Biochem J88, 5-25. PubMed Europe PubMed I
Vahatupa,M., Aittomaki,S., Martinez Cordova,Z., May,U., Prince,S., Uusitalo-Jarvinen,H., Jarvinen,T.A. and Pesu,M.
T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development
Oncoimmunology5, e1245266-e1245266. PubMed Europe PubMed DOI
Wilbers,R.H.P., Westerhof,L.B., vanRaaij,D.R., vanAdrichem,M., Prakasa,A.D., Lozano-Torres,J.L., Bakker,J., Smant,G. and Schots,A.
Co-expression of the protease furin in Nicotiana benthamiana leads to efficient processing of latent transforming growth factor-beta1 into a biologically active protein
Plant Biotechnol J14, 1695-1704. PubMed Europe PubMed DOI

2015

Bessonnard,S., Mesnard,D. and Constam,D.B.
PC7 and the related proteases furin and pace4 regulate E-cadherin function during blastocyst formation
J Cell Biol210, 1185-1197. PubMed Europe PubMed DOI
Couture,F., Kwiatkowska,A., Dory,Y.L. and Day,R.
Therapeutic uses of furin and its inhibitors: a patent review
Expert Opin Ther Pat25, 379-396. PubMed Europe PubMed DOI U I
Elferich,J., Williamson,D.M., David,L.L. and Shinde,U.
Determination of histidine pKa values in the propeptides of furin and proprotein convertase1/3 using histidine hydrogen-deuterium exchange mass spectrometry
Anal Chem87, 7909-7917. PubMed Europe PubMed DOI
Fittler,H., Depp,A., Avrutina,O., Dahms,S.O., Than,M.E., Empting,M. and Kolmar,H.
Engineering a constrained peptidic scaffold towards potent and selective furin inhibitors
Chembiochem16, 2441-2444. PubMed Europe PubMed DOI
Hardes,K., Becker,G.L., Lu,Y., Dahms,S.O., Kohler,S., Beyer,W., Sandvig,K., Yamamoto,H., Lindberg,I., Walz,L., von Messling,V., Than,M.E., Garten,W. and Steinmetzer,T.
Novel furin inhibitors with potent anti-infectious activity
ChemMedChem10, 1218-1231. PubMed Europe PubMed DOI S I
Jiang,T., Sun,W., Zhu,Q., Burns,N.A., Khan,S.A., Mo,R. and Gu,Z.
Drug delivery: furin-mediated sequential delivery of anticancer cytokine and small-molecule drug shuttled by graphene (adv. Mater. 6/2015)
Adv Mater27, 958-958. DOI
Kibirev,V.K., Osadchuk,T.V., Rodik,R.V. and Kalchenko,V.I.
Furin inhibitors based on the derivatives of calix[4]arene CX3im
Ukr Biochem J87, 31-36. PubMed Europe PubMed I
Kibirev,V.K., Osadchuk,T.V., Kozachenko,O.P., Kholodovych,V., Fedoryak,D. and Brovarets,V.S.
Synthesis, biological evaluation and docking of novel bisamidinohydrazones as non-peptide inhibitors of furin
Ukr Biochem J87, 55-63. PubMed Europe PubMed I
Layne,J.D., Shridas,P. and Webb,N.R.
Ectopically expressed pro-group X secretory phospholipase A2 is proteolytically activated in mouse adrenal cells by furin-like proprotein convertases: implications for the regulation of adrenal steroidogenesis
J Biol Chem290, 7851-7860. PubMed Europe PubMed DOI
Li,W., Wicht,O., van Kuppeveld,F.J., He,Q., Rottier,P.J. and Bosch,B.J.
A single point mutation creating a furin cleavage site in the spike protein renders porcine epidemic diarrhea coronavirus trypsin independent for cell entry and fusion
J Virol89, 8077-8081. PubMed Europe PubMed DOI
Omotuyi,O.I. and Hamada,T.
Human furin Cys198 imposes dihedral and positional restraints on His194 for optimal Ser386-proton transfer
J Biomol Struct Dyn33, 2442-2451. PubMed Europe PubMed DOI
Ramos-Molina,B., Lick,A.N., Nasrolahi Shirazi,A., Oh,D., Tiwari,R., El-Sayed,N.S., Parang,K. and Lindberg,I.
Cationic cell-penetrating peptides are potent furin inhibitors
PLoS ONE10, e0130417-e0130417. PubMed Europe PubMed DOI I
Ramos-Molina,B., Lick,A.N., Blanco,E.H., Posada-Salgado,J.A., Martinez-Mayorga,K., Johnson,A.T., Jiao,G.S. and Lindberg,I.
Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays
Biochem Pharmacol96, 107-118. PubMed Europe PubMed DOI I
Wiens,M.E. and Smith,J.G.
Alpha-defensin HD5 inhibits furin cleavage of human papillomavirus 16 L2 to block infection
J Virol89, 2866-2874. PubMed Europe PubMed DOI
Yuan,Y., Zhang,J., Cao,Q., An,L. and Liang,G.
Intracellular disassembly of self-quenched nanoparticles turns NIR fluorescence on for sensing furin activity in cells and in tumors
Anal Chem87, 6180-6185. PubMed Europe PubMed DOI L

2014

Dahms,S.O., Hardes,K., Becker,G.L., Steinmetzer,T., Brandstetter,H. and Than,M.E.
X-ray structures of human furin in complex with competitive inhibitors
ACS Chem Biol9, 1113-1118. PubMed Europe PubMed DOI S I
Gagnon,H., Beauchemin,S., Kwiatkowska,A., Couture,F., D'Anjou,F., Levesque,C., Dufour,F., Desbiens,A.R., Vaillancourt,R., Bernard,S., Desjardins,R., Malouin,F., Dory,Y.L. and Day,R.
Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin
J Med Chem57, 29-41. PubMed Europe PubMed DOI I
Harihar,S., Pounds,K.M., Iwakuma,T., Seidah,N.G. and Welch,D.R.
Furin is the major proprotein convertase required for KISS1-to-kisspeptin processing
PLoS ONE9, e84958-e84958. PubMed Europe PubMed DOI
Millet,J.K. and Whittaker,G.R.
Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein
Proc Natl Acad Sci U S A111, 15214-15219. PubMed Europe PubMed DOI P
Mu,J., Liu,F., Rajab,M.S., Shi,M., Li,S., Goh,C., Lu,L., Xu,Q.H., Liu,B., Ng,L.G. and Xing,B.
A small-molecule FRET reporter for the real-time visualization of cell-surface proteolytic enzyme functions
Angew Chem Int Ed Engl53, 14357-14362. PubMed Europe PubMed DOI L
Tse,L.V., Hamilton,A.M., Friling,T. and Whittaker,G.R.
A novel activation mechanism of avian influenza virus H9N2 by furin
J Virol88, 1673-1683. PubMed Europe PubMed DOI

2013

Cao,C.Y., Shen,Y.Y., Wang,J.D., Li,L. and Liang,G.L.
Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents
Sci Rep3, 1024-1024. PubMed Europe PubMed DOI L
Ennemann,E.C., Radhakrishnan,K., Mariappan,M., Wachs,M., Pringle,T.H., Schmidt,B. and Dierks,T.
Proprotein convertases process and thereby inactivate formylglycine-generating enzyme
J Biol Chem288, 5828-5839. PubMed Europe PubMed DOI P
Guillemot,J., Canuel,M., Essalmani,R., Prat,A. and Seidah,N.G.
Implication of the proprotein convertases in iron homeostasis: Proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin
Hepatology57, 2514-2524. PubMed Europe PubMed DOI P
Guo,H.F., Li,X., Parker,M.W., Waltenberger,J., Becker,P.M. and Vander Kooi,C.W.
Mechanistic basis for the potent anti-angiogenic activity of semaphorin 3F
Biochemistry52, 7551-7558. PubMed Europe PubMed DOI
Hada,K., Isshiki,K., Matsuda,S., Yuasa,K. and Tsuji,A.
Engineering of alpha1-antitrypsin variants with improved specificity for the proprotein convertase furin using site-directed random mutagenesis
Protein Eng Des Sel26, 123-131. PubMed Europe PubMed DOI
Izaguirre,G., Qi,L., Lima,M. and Olson,S.T.
Identification of serpin determinants of specificity and selectivity for furin inhibition through studies of alpha1PDX (alpha1-protease inhibitor Portland)-serpin B8 and furin active-site loop chimeras
J Biol Chem288, 21802-21814. PubMed Europe PubMed DOI
Kato,S., Zhang,R. and Roberts,J.D., Jr.
Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport
Am J Physiol Lung Cell Mol Physiol305, L130-L140. PubMed Europe PubMed DOI
Kibirev,V.K., Osadchuk,T.V., Kozachenko,A.P., Vadziuk,O.B. and Brovarets,V.S.
[Non-peptide furin inhibitors based on amidinohydrazones of diarylaldehydes]
Ukr Biokhim Zh85, 22-32. PubMed Europe PubMed I
Lalou,C., Basak,A., Mishra,P., Mohanta,B.C., Banik,R., Dinda,B. and Khatib,A.M.
Inhibition of tumor cells proliferation and migration by the flavonoid furin inhibitor isolated from Oroxylum Indicum
Curr Med Chem20, 583-591. PubMed Europe PubMed I
Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.
The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions
J Biol Chem288, 21473-21481. PubMed Europe PubMed DOI V
Shin,K., Pandey,A., Liu,X.Q., Anini,Y. and Rainey,J.K.
Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity
FEBS Open Bio3, 328-333. PubMed Europe PubMed DOI P
Shiryaev,S.A., Chernov,A.V., Golubkov,V.S., Thomsen,E.R., Chudin,E., Chee,M.S., Kozlov,I.A., Strongin,A.Y. and Cieplak,P.
High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome
PLoS ONE8, e54290-e54290. PubMed Europe PubMed DOI P
Turpeinen,H., Ortutay,Z. and Pesu,M.
Genetics of the first seven proprotein convertase enzymes in health and disease
Curr Genomics14, 453-467. PubMed Europe PubMed DOI V
Urban,D., Lorenz,J., Meyborg,H., Ghosh,S., Kintscher,U., Kaufmann,J., Fleck,E., Kappert,K. and Stawowy,P.
Proprotein convertase furin enhances survival and migration of vascular smooth muscle cells via processing of pro-nerve growth factor
J Biochem153, 197-207. PubMed Europe PubMed DOI
Williamson,D.M., Elferich,J., Ramakrishnan,P., Thomas,G. and Shinde,U.
The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin
J Biol Chem288, 19154-19165. PubMed Europe PubMed DOI

2012

Becker,G.L., Lu,Y., Hardes,K., Strehlow,B., Levesque,C., Lindberg,I., Sandvig,K., Bakowsky,U., Day,R., Garten,W. and Steinmetzer,T.
Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases
J Biol Chem287, 21992-22003. PubMed Europe PubMed DOI I
Declercq,J. and Creemers,J.W.M.
Furin
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Dillon,S.L., Williamson,D.M., Elferich,J., Radler,D., Joshi,R., Thomas,G. and Shinde,U.
Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3
J Mol Biol423, 47-62. PubMed Europe PubMed DOI
Lopez-Vallejo,F. and Martinez-Mayorga,K.
Furin inhibitors: importance of the positive formal charge and beyond
Bioorg Med Chem20, 4462-4471. PubMed Europe PubMed DOI V I
Seidah,N.G. and Prat,A.
The biology and therapeutic targeting of the proprotein convertases
Nat Rev Drug Discov11, 367-383. PubMed Europe PubMed DOI V
Tian,S., Huajun,W. and Wu,J.
Computational prediction of furin cleavage sites by a hybrid method and understanding mechanism underlying diseases
Sci Rep2, 261-261. PubMed Europe PubMed DOI P

2011

Basak,A., Chen,A., Majumdar,S. and Smith,H.P.
In vitro assay for protease activity of proprotein convertase subtilisin kexins (PCSKs): an overall review of existing and new methodologies
Methods Mol Biol768, 127-153. PubMed Europe PubMed DOI A
Becker,G.L., Hardes,K. and Steinmetzer,T.
New substrate analogue furin inhibitors derived from 4-amidinobenzylamide
Bioorg Med Chem Lett21, 4695-4697. PubMed Europe PubMed DOI I
Bernot,D., Stalin,J., Stocker,P., Bonardo,B., Scroyen,I., Alessi,M.C. and Peiretti,F.
Plasminogen activator inhibitor 1 is an intracellular inhibitor of furin proprotein convertase
J Cell Sci124, 1224-1230. PubMed Europe PubMed DOI
Biswas,A., Joo,K.I., Liu,J., Zhao,M., Fan,G., Wang,P., Gu,Z. and Tang,Y.
Endoprotease-mediated intracellular protein delivery using nanocapsules
ACS Nano5, 1385-1394. PubMed Europe PubMed DOI
Bourne,G.L. and Grainger,D.J.
Development and characterisation of an assay for furin activity
J Immunol Methods364, 101-108. PubMed Europe PubMed DOI A
Essalmani,R., Susan-Resiga,D., Chamberland,A., Abifadel,M., Creemers,J.W., Boileau,C., Seidah,N.G. and Prat,A.
In vivo evidence that furin from hepatocytes inactivates PCSK9
J Biol Chem286, 4257-4263. PubMed Europe PubMed DOI
Gram Schjoldager,K.T., Vester-Christensen,M.B., Goth,C.K., Petersen,T.N., Brunak,S., Bennett,E.P., Levery,S.B. and Clausen,H.
A systematic study of site-specific GalNAc-type O-glycosylation modulating proprotein convertase processing
J Biol Chem286, 40122-40132. PubMed Europe PubMed DOI
Kibirev,V.K., Osadchuk,T.V., Vadziuk,O.B., Shablykin,O.V., Kozachenko,A.P., Chumachenko,S.A., Popil'nichenko,S.V. and Brovarets,V.S.
[Study on derivatives of 5-amino-4-acylamino-1H-pyrazole as inhibitors of furin]
Ukr Biokhim Zh83, 30-37. PubMed Europe PubMed I
Kuester,M., Becker,G.L., Hardes,K., Lindberg,I., Steinmetzer,T. and Than,M.E.
Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors
Biol Chem392, 973-981. PubMed Europe PubMed DOI
Mesnard,D., Donnison,M., Fuerer,C., Pfeffer,P.L. and Constam,D.B.
The microenvironment patterns the pluripotent mouse epiblast through paracrine furin and pace4 proteolytic activities
Genes Dev25, 1871-1880. PubMed Europe PubMed DOI
Seidah,N.G.
The proprotein convertases, 20 years later
Methods Mol Biol768, 23-57. PubMed Europe PubMed DOI V
Seidah,N.G.
What lies ahead for the proprotein convertases?
Ann N Y Acad Sci1220, 149-161. PubMed Europe PubMed DOI V
Sielaff,F., Than,M.E., Bevec,D., Lindberg,I. and Steinmetzer,T.
New furin inhibitors based on weakly basic amidinohydrazones
Bioorg Med Chem Lett21, 836-840. PubMed Europe PubMed DOI I
Susan-Resiga,D., Essalmani,R., Hamelin,J., Asselin,M.C., Benjannet,S., Chamberland,A., Day,R., Szumska,D., Constam,D., Bhattacharya,S., Prat,A. and Seidah,N.G.
Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10
J Biol Chem286, 22785-22794. PubMed Europe PubMed DOI
Tian,S., Huang,Q., Fang,Y. and Wu,J.
FurinDB: a database of 20-residue furin cleavage site motifs, substrates and their associated drugs
Int J Mol Sci12, 1060-1065. PubMed Europe PubMed DOI P

2010

Becker,G.L., Sielaff,F., Than,M.E., Lindberg,I., Routhier,S., Day,R., Lu,Y., Garten,W. and Steinmetzer,T.
Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics
J Med Chem53, 1067-1075. PubMed Europe PubMed DOI I
Gawlik,K., Remacle,A.G., Shiryaev,S.A., Golubkov,V.S., Ouyang,M., Wang,Y. and Strongin,A.Y.
A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen
PLoS ONE5, e11305-e11305. PubMed Europe PubMed DOI A
Izidoro,M.A., Assis,D.M., Oliveira,V., Santos,J.A., Juliano,M.A., Lindberg,I. and Juliano,L.
Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein
Biol Chem391, 1105-1112. PubMed Europe PubMed DOI P
Kelty,B.P. and Curry,T.E., Jr.
Ovarian furin (proprotein convertase subtilisin/kexin type3): expression, localization, and potential role in ovulation in the rat
Biol Reprod83, 147-154. PubMed Europe PubMed DOI I
Khatib,A.M., Lahlil,R., Scamuffa,N., Akimenko,M.A., Ernest,S., Lomri,A., Lalou,C., Seidah,N.G., Villoutreix,B.O., Calvo,F. and Siegfried,G.
Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration
PLoS ONE5, e11438-e11438. PubMed Europe PubMed DOI I
Majumdar,S., Mohanta,B.C., Chowdhury,D.R., Banik,R., Dinda,B. and Basak,A.
Proprotein convertase inhibitory activities of flavonoids isolated from Oroxylum indicum
Curr Med Chem17, 2049-2058. PubMed Europe PubMed DOI I
Parker,M.W., Hellman,L.M., Xu,P., Fried,M.G. and Vander Kooi,C.W.
Furin processing of semaphorin 3F determines its anti-angiogenic activity by regulating direct binding and competition for neuropilin
Biochemistry49, 4068-4075. PubMed Europe PubMed DOI P
Remacle,A.G., Gawlik,K., Golubkov,V.S., Cadwell,G.W., Liddington,R.C., Cieplak,P., Millis,S.Z., Desjardins,R., Routhier,S., Yuan,X.W., Neugebauer,W.A., Day,R. and Strongin,A.Y.
Selective and potent furin inhibitors protect cells from anthrax without significant toxicity
Int J Biochem Cell Biol42, 987-995. PubMed Europe PubMed DOI I
Semenov,A.G., Tamm,N.N., Seferian,K.R., Postnikov,A.B., Karpova,N.S., Serebryanaya,D.V., Koshkina,E.V., Krasnoselsky,M.I. and Katrukha,A.G.
Processing of pro-B-type natriuretic peptide: furin and corin as candidate convertases
Clin Chem56, 1166-1176. PubMed Europe PubMed DOI
Tian,S. and Jianhua,W.
Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors
Int J Biol Sci6, 89-95. PubMed Europe PubMed P I

2009

Basak,A., Khatib,A.M., Mohottalage,D., Basak,S., Kolajova,M., Bag,S.S. and Basak,A.
A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C
PLoS ONE4, e7700-e7700. PubMed Europe PubMed DOI I
Day,P.M. and Schiller,J.T.
The role of furin in papillomavirus infection
Future Microbiol4, 1255-1262. PubMed Europe PubMed DOI
Dragulescu-Andrasi,A., Liang,G. and Rao,J.
In vivo bioluminescence imaging of furin activity in breast cancer cells using bioluminogenic substrates
Bioconjug Chem20, 1660-1666. PubMed Europe PubMed DOI L
Izidoro,M.A., Gouvea,I.E., Santos,J.A., Assis,D.M., Oliveira,V., Judice,W.A., Juliano,M.A., Lindberg,I. and Juliano,L.
A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions
Arch Biochem Biophys487, 105-114. PubMed Europe PubMed DOI P
Komiyama,T., Coppola,J.M., Larsen,M.J., van Dort,M.E., Ross,B.D., Day,R., Rehemtulla,A. and Fuller,R.S.
Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small molecules
J Biol Chem284, 15729-15738. PubMed Europe PubMed DOI I
Longpre,J.M., McCulloch,D.R., Koo,B.H., Alexander,J.P., Apte,S.S. and Leduc,R.
Characterization of proADAMTS5 processing by proprotein convertases
Int J Biochem Cell Biol41, 1116-1126. PubMed Europe PubMed DOI
Nelsen,S.M. and Christian,J.L.
Site-specific cleavage of BMP4 by furin, PC6, and PC7
J Biol Chem284, 27157-27166. PubMed Europe PubMed DOI
Rholam,M. and Fahy,C.
Processing of peptide and hormone precursors at the dibasic cleavage sites
Cell Mol Life Sci66, 2075-2091. PubMed Europe PubMed DOI
Yamada,Y. and Liu,D.X.
Proteolytic activation of the spike protein at a novel RRRR/S motif is implicated in furin-dependent entry, syncytium formation, and infectivity of coronavirus infectious bronchitis virus in cultured cells
J Virol83, 8744-8758. PubMed Europe PubMed DOI

2008

Creemers,J.W. and Khatib,A.M.
Knock-out mouse models of proprotein convertases: unique functions or redundancy?
Front Biosci13, 4960-4971. PubMed Europe PubMed DOI K
De Vos,L., Declercq,J., Rosas,G.G., Van Damme,B., Roebroek,A., Vermorken,F., Ceuppens,J., Van De Ven,W. and Creemers,J.
MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice
Int J Oncol32, 1073-1083. PubMed Europe PubMed K
Louagie,E., Taylor,N.A., Flamez,D., Roebroek,A.J., Bright,N.A., Meulemans,S., Quintens,R., Herrera,P.L., Schuit,F., Van de Ven,W.J. and Creemers,J.W.
Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate
Proc Natl Acad Sci U S A105, 12319-12324. PubMed Europe PubMed DOI K
Pesu,M., Watford,W.T., Wei,L., Xu,L., Fuss,I., Strober,W., Andersson,J., Shevach,E.M., Quezado,M., Bouladoux,N., Roebroek,A., Belkaid,Y., Creemers,J. and O'Shea,J.J.
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
Nature455, 246-250. PubMed Europe PubMed DOI
Remacle,A.G., Shiryaev,S.A., Oh,E.S., Cieplak,P., Srinivasan,A., Wei,G., Liddington,R.C., Ratnikov,B.I., Parent,A., Desjardins,R., Day,R., Smith,J.W., Lebl,M. and Strongin,A.Y.
Substrate cleavage analysis of furin and related proprotein convertases. A comparative study
J Biol Chem283, 20897-20906. PubMed Europe PubMed DOI P
Scamuffa,N., Siegfried,G., Bontemps,Y., Ma,L., Basak,A., Cherel,G., Calvo,F., Seidah,N.G. and Khatib,A.M.
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells
J Clin Invest118, 352-363. PubMed Europe PubMed DOI

2007

Bhattacharjya,S., Xu,P., Wang,P., Osborne,M.J. and Ni,F.
Conformational analyses of a partially-folded bioactive prodomain of human furin
Biopolymers86, 329-344. PubMed Europe PubMed DOI
Hall,T., Fok,K.F., Liu,M.M., Zobel,J.F., Marino,M.H., Malfait,A.M., Tortorella,M.D. and Tomasselli,A.G.
A high performance liquid chromatography assay for monitoring proprotein convertase activity
J Chromatogr A1148, 46-54. PubMed Europe PubMed DOI A
Veit,G., Zimina,E.P., Franzke,C.W., Kutsch,S., Siebolds,U., Gordon,M.K., Bruckner-Tuderman,L. and Koch,M.
Shedding of collagen XXIII is mediated by furin and depends on the plasma membrane microenvironment
J Biol Chem282, 27424-27435. PubMed Europe PubMed DOI

2006

[YEAR:6-4-2006]Feliciangeli,S.F., Thomas,L., Scott,G.K., Subbian,E., Hung,C.H., Molloy,S.S., Jean,F., Shinde,U. and Thomas,G.
Identification of a pH sensor in the furin propeptide that regulates enzyme activation
J Biol Chem281, 16108-16116. PubMed Europe PubMed DOI
Jiao,G.S., Cregar,L., Wang,J., Millis,S.Z., Tang,C., O'Malley,S., Johnson,A.T., Sareth,S., Larson,J. and Thomas,G.
Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine
Proc Natl Acad Sci U S A103, 19707-19712. PubMed Europe PubMed DOI I
[YEAR:24-4-2006]Remacle,A.G., Rozanov,D.V., Fugere,M., Day,R. and Strongin,A.Y.
Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP
Oncogene25, 5648-5655. PubMed Europe PubMed DOI
Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.
Proprotein convertases: lessons from knockouts
FASEB J20, 1954-1963. PubMed Europe PubMed DOI K V
Tao,H., Zhang,Z., Shi,J., Shao,X.X., Cui,D. and Chi,C.W.
Template-assisted rational design of peptide inhibitors of furin using the lysine fragment of the mung bean trypsin inhibitor
FEBS J273, 3907-3914. PubMed Europe PubMed DOI

2005

[YEAR:6-1-2005]Cao,J., Rehemtulla,A., Pavlaki,M., Kozarekar,P. and Chiarelli,C.
Furin directly cleaves proMMP-2 in the trans-golgi network resulting in a nonfunctioning proteinase
J Biol Chem280, 10974-10980. PubMed Europe PubMed DOI
[YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E.
Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity
J Mol Biol345, 211-227. PubMed Europe PubMed DOI S
Komiyama,T., Swanson,J.A. and Fuller,R.S.
Protection from anthrax toxin-mediated killing of macrophages by the combined effects of furin inhibitors and chloroquine
Antimicrob Agents Chemother49, 3875-3882. PubMed Europe PubMed DOI I
[YEAR:20-4-2005]Nelsen,S., Berg,L., Wong,C. and Christian,J.L.
Proprotein convertase genes in Xenopus development
Dev Dyn233, 1038-1044. PubMed Europe PubMed DOI
Than,M.E., Henrich,S., Bourenkov,G.P., Bartunik,H.D., Huber,R. and Bode,W.
The endoproteinase furin contains two essential Ca2+ ions stabilizing its N-terminus and the unique S1 specificity pocket
Acta Crystallogr D Biol Crystallogr61, 505-512. PubMed Europe PubMed DOI

2004

[YEAR:1-5-2004]Bissonnette,L., Charest,G., Longpre,J.M., Lavigne,P. and Leduc,R.
Identification of furin pro-region determinants involved in folding and activation
Biochem J379, 757-763. PubMed Europe PubMed DOI
Creemers,J.W.M. and Van de Ven,W.J.M.
Furin
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Dey,A., Norrbom,C., Zhu,X., Stein,J., Zhang,C., Ueda,K. and Steiner,D.F.
Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone
Endocrinology145, 1961-1971. PubMed Europe PubMed DOI
Duckert,P., Brunak,S. and Blom,N.
Prediction of proprotein convertase cleavage sites
Protein Eng Des Sel17, 107-112. PubMed Europe PubMed DOI
[YEAR:9-3-2004]Holyoak,T., Kettner,C.A., Petsko,G.A., Fuller,R.S. and Ringe,D.
Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases
Biochemistry43, 2412-2421. PubMed Europe PubMed DOI S I
[YEAR:3-11-2004]Matsuzawa,T., Fukui,A., Kashimoto,T., Nagao,K., Oka,K., Miyake,M. and Horiguchi,Y.
Bordetella dermonecrotic toxin undergoes proteolytic processing to be translocated from a dynamin-related endosome into the cytoplasm in an acidification-independent manner
J Biol Chem279, 2866-2872. PubMed Europe PubMed DOI
Mayer,G., Boileau,G. and Bendayan,M.
The proprotein convertase furin colocalizes with caveolin-1 in the Golgi apparatus and endosomes of hepatocytes
Cell Tissue Res316, 55-63. PubMed Europe PubMed DOI
[YEAR:5-11-2004]Oley,M., Letzel,M.C. and Ragg,H.
Inhibition of furin by serpin Spn4A from Drosophila melanogaster
FEBS Lett577, 165-169. PubMed Europe PubMed DOI
[YEAR:27-8-2004]Peinado,J.R., Kacprzak,M.M., Leppla,S.H. and Lindberg,I.
Cross-inhibition between furin and lethal factor inhibitors
Biochem Biophys Res Commun321, 601-605. PubMed Europe PubMed DOI I
Posner,S.F., Vaslet,C.A., Jurofcik,M., Lee,A., Seidah,N.G. and Nillni,E.A.
Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1
Endocrine23, 199-213. PubMed Europe PubMed DOI
Rockwell,N.C. and Thorner,J.W.
The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing
Trends Biochem Sci29, 80-87. PubMed Europe PubMed DOI S
[YEAR:7-10-2004]Roebroek,A.J., Taylor,N.A., Louagie,E., Pauli,I., Smeijers,L., Snellinx,A., Lauwers,A., Van de Ven,W.J., Hartmann,D. and Creemers,J.W.
Limited redundancy of the proprotein convertase furin in mouse liver
J Biol Chem279, 53442-53450. PubMed Europe PubMed DOI
[YEAR:26-1-2004]Wang,P., Tortorella,M., England,K., Malfait,A.M., Thomas,G., Arner,E.C. and Pei,D.
Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (aggrecanase-1) in the trans-Golgi network
J Biol Chem279, 15434-15440. PubMed Europe PubMed DOI

2003

[YEAR:15-7-2003]Bergeron,E., Basak,A., Decroly,E. and Seidah,N.G.
Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage
Biochem J373, 475-484. PubMed Europe PubMed DOI
Henrich,S., Cameron,A., Bourenkov,G.P., Kiefersauer,R., Huber,R., Lindberg,I., Bode,W. and Than,M.E.
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity
Nat Struct Biol10, 520-526. PubMed Europe PubMed DOI S I
[YEAR:14-11-2003]Huff,M.E., Page,L.J., Balch,W.E. and Kelly,J.W.
Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin proteolysis and familial amyloidosis of Finnish type
J Mol Biol334, 119-127. PubMed Europe PubMed DOI
[YEAR:8-7-2003]Komiyama,T., VanderLugt,B., Fugere,M., Day,R., Kaufman,R.J. and Fuller,R.S.
Optimization of protease-inhibitor interactions by randomizing adventitious contacts
Proc Natl Acad Sci U S A100, 8205-8210. PubMed Europe PubMed DOI
[YEAR:1-5-2003]Peiretti,F., Canault,M., Deprez-Beauclair,P., Berthet,V., Bonardo,B., Juhan-Vague,I. and Nalbone,G.
Intracellular maturation and transport of tumor necrosis factor alpha converting enzyme
Exp Cell Res285, 278-285. PubMed Europe PubMed DOI
Siegfried,G., Basak,A., Cromlish,J.A., Benjannet,S., Marcinkiewicz,J., Chretien,M., Seidah,N.G. and Khatib,A.M.
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis
J Clin Invest111, 1723-1732. PubMed Europe PubMed DOI
Taylor,N.A., Van de Ven,W.J. and Creemers,J.W.
Curbing activation: proprotein convertases in homeostasis and pathology
FASEB J17, 1215-1227. PubMed Europe PubMed DOI K
Zhang,X., Fugere,M., Day,R. and Kielian,M.
Furin processing and proteolytic activation of Semliki Forest virus
J Virol77, 2981-2989. PubMed Europe PubMed DOI

2002

[YEAR:12-4-2002]Anderson,E.D., Molloy,S.S., Jean,F., Fei,H., Shimamura,S. and Thomas,G.
The ordered and compartment-specific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation
J Biol Chem277, 12879-12890. PubMed Europe PubMed DOI
Beck,S., Le Good,J.A., Guzman,M., Ben Haim,N., Roy,K., Beermann,F. and Constam,D.B.
Extraembryonic proteases regulate Nodal signalling during gastrulation
Nat Cell Biol4, 981-985. PubMed Europe PubMed DOI
Blais,V., Fugere,M., Denault,J.B., Klarskov,K., Day,R. and Leduc,R.
Processing of proendothelin-1 by members of the subtilisin-like pro-protein convertase family
FEBS Lett524, 43-48. PubMed Europe PubMed DOI
[YEAR:10-5-2002]Bowler,R.P., Nicks,M., Olsen,D.A., Thogersen,I.B., Valnickova,Z., Hojrup,P., Franzusoff,A., Enghild,J.J. and Crapo,J.D.
Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase
J Biol Chem277, 16505-16511. PubMed Europe PubMed DOI
Fugere,M. and Day,R.
Inhibitors of the subtilase-like pro-protein convertases (SPCs)
Curr Pharm Des8, 549-562. PubMed Europe PubMed DOI V I
[YEAR:1-2-2002]Kang,T., Nagase,H. and Pei,D.
Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network
Cancer Res62, 675-681. PubMed Europe PubMed
Seidah,N.G. and Prat,A.
Precursor convertases in the secretory pathway, cytosol and extracellular milieu
Essays Biochem38, 79-94. PubMed Europe PubMed
Thomas,G.
Furin at the cutting edge: from protein traffic to embryogenesis and disease
Nat Rev Mol Cell Biol3, 753-766. PubMed Europe PubMed DOI V

2001

Bassi,D.E., Mahloogi,H., Al-Saleem,L., Lopez de Cicco,R., Ridge,J.A. and Klein-Szanto,A.J.
Elevated furin expression in aggressive human head and neck tumors and tumor cell lines
Mol Carcinog31, 224-232. PubMed Europe PubMed DOI
Bhattacharjya,S., Xu,P., Xiang,H., Chretien,M., Seidah,N.G. and Ni,F.
pH-Induced conformational transitions of a molten-globule-like state of the inhibitory prodomain of furin: implications for zymogen activation
Protein Sci10, 934-942. PubMed Europe PubMed DOI
Chan,M. and Bennick,A.
Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases
Eur J Biochem268, 3423-3431. PubMed Europe PubMed DOI
[YEAR:19-6-2001]Chen,Y.W., Molloy,S.S., Thomas,L., Gambee,J., Bachinger,H.P., Ferguson,B., Zonana,J., Thomas,G. and Morris,N.P.
Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia
Proc Natl Acad Sci U S A98, 7218-7223. PubMed Europe PubMed DOI
Pinnix,I., Council,J.E., Roseberry,B., Onstead,L., Mallender,W., Sucic,J. and Sambamurti,K.
Convertases other than furin cleave beta-secretase to its mature form
FASEB J15, 1810-1812. PubMed Europe PubMed I
Sugrue,R.J., Brown,C., Brown,G., Aitken,J. and McL Rixon,H.W.
Furin cleavage of the respiratory syncytial virus fusion protein is not a requirement for its transport to the surface of virus-infected cells
J Gen Virol82, 1375-1386. PubMed Europe PubMed I
[YEAR:21-9-2001]Wang,X. and Pei,D.
Shedding of membrane type matrix metalloproteinase 5 by a furin-type convertase: a potential mechanism for down-regulation
J Biol Chem276, 35953-35960. PubMed Europe PubMed DOI I
Zhang,Y., Kida,Y., Kuwano,K., Misumi,Y., Ikehara,Y. and Arai,S.
Role of furin in delivery of a CTL epitope of an anthrax toxin-fusion protein
Microbiol Immunol45, 119-125. PubMed Europe PubMed

2000

[YEAR:24-10-2000]Bass,J., Turck,C., Rouard,M. and Steiner,D.F.
Furin-mediated processing in the early secretory pathway: Sequential cleavage and degradation of misfolded insulin receptors
Proc Natl Acad Sci U S A97, 11905-11909. PubMed Europe PubMed DOI
Bassi,D.E., Mahloogi,H. and Klein-Szanto,A.J.
The proprotein convertases furin and PACE4 play a significant role in tumor progression
Mol Carcinog28, 63-69. PubMed Europe PubMed DOI
[YEAR:1-12-2000]Bennett,B.D., Denis,P., Haniu,M., Teplow,D.B., Kahn,S., Louis,J.C., Citron,M. and Vassar,R.
A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta-secretase
J Biol Chem275, 37712-37717. PubMed Europe PubMed DOI
[YEAR:24-11-2000]Cameron,A., Appel,J., Houghten,R.A. and Lindberg,I.
Polyarginines are potent furin inhibitors
J Biol Chem275, 36741-36749. PubMed Europe PubMed DOI I
Denault,J.B., Lazure,C., Day,R. and Leduc,R.
Comparative characterization of two forms of recombinant human SPC1 secreted from Schneider 2 cells
Protein Expr Purif19, 113-124. PubMed Europe PubMed DOI E
[YEAR:14-3-2000]Jean,F., Thomas,L., Molloy,S.S., Liu,G., Jarvis,M.A., Nelson,J.A. and Thomas,G.
A protein-based therapeutic for human cytomegalovirus infection
Proc Natl Acad Sci U S A97, 2864-2869. PubMed Europe PubMed DOI
[YEAR:12-12-2000]Komiyama,T. and Fuller,R.S.
Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin
Biochemistry39, 15156-15165. PubMed Europe PubMed DOI

1999

[YEAR:13-8-1999]Krysan,D.J., Rockwell,N.C. and Fuller,R.S.
Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides
J Biol Chem274, 23229-23234. PubMed Europe PubMed DOI P
Molloy,S.S., Anderson,E.D., Jean,F. and Thomas,G.
Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis
Trends Cell Biol9, 28-35. PubMed Europe PubMed DOI
Preininger,A., Schlokat,U., Mohr,G., Himmelspach,M., Stichler,V., Kyd-Rebenburg,A., Plaimauer,B., Turecek,P.L., Schwarz,H.P., Wernhart,W., Fischer,B.E. and Dorner,F.
Strategies for recombinant furin employment in a biotechnological process: complete target protein precursor cleavage
Cytotechnology30, 1-16. PubMed Europe PubMed DOI E
[YEAR:27-11-1999]Seidah,N.G. and Chretien,M.
Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides
Brain Res848, 45-62. PubMed Europe PubMed DOI K

1998

Cieplik,M., Klenk,H.D. and Garten,W.
Identification and characterization of Spodoptera frugiperda furin: a thermostable subtilisin-like endopeptidase
Biol Chem379, 1433-1440. PubMed Europe PubMed
[YEAR:23-1-1998]Dahlen,J.R., Jean,F., Thomas,G., Foster,D.C. and Kisiel,W.
Inhibition of soluble recombinant furin by human proteinase inhibitor 8
J Biol Chem273, 1851-1854. PubMed Europe PubMed DOI
[YEAR:10-4-1998]Dufour,E.K., Denault,J.B., Hopkins,P.C. and Leduc,R.
Serpin-like properties of alpha1-antitrypsin Portland towards furin convertase
FEBS Lett426, 41-46. PubMed Europe PubMed
Jean,F., Stella,K., Thomas,L., Liu,G., Xiang,Y., Reason,A.J. and Thomas,G.
alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent
Proc Natl Acad Sci U S A95, 7293-7298. PubMed Europe PubMed DOI M I
[YEAR:10-4-1998]Lazure,C., Gauthier,D., Jean,F., Boudreault,A., Seidah,N.G., Bennett,H.P. and Hendy,G.N.
In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor
J Biol Chem273, 8572-8580. PubMed Europe PubMed DOI I
[YEAR:13-3-1998]Maquoi,E., Noel,A., Frankenne,F., Angliker,H., Murphy,G. and Foidart,J.M.
Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor
FEBS Lett424, 262-266. PubMed Europe PubMed DOI I
Roebroek,A.J., Umans,L., Pauli,I.G., Robertson,E.J., Van Leuven,F., Van de Ven,W.J. and Constam,D.B.
Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase furin
Development125, 4863-4876. PubMed Europe PubMed K

1997

Anderson,E.D., VanSlyke,J.K., Thulin,C.D., Jean,F. and Thomas,G.
Activation of the furin endoprotease is a multiple-step process: Requirements for acidification and internal propeptide cleavage
EMBO J16, 1508-1518. PubMed Europe PubMed DOI
Blanchette,F., Day,R., Dong,W., Laprise,M.H. and Dubois,C.M.
TGF beta 1 regulates gene expression of its own converting enzyme furin
J Clin Invest99, 1974-1983. PubMed Europe PubMed DOI
Decroly,E., Benjannet,S., Savaria,D. and Seidah,N.G.
Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160
FEBS Lett405, 68-72. PubMed Europe PubMed DOI
Van Rompaey,L., Ayoubi,T., Van De Ven,W. and Marynen,P.
Inhibition of intracellular proteolytic processing of soluble proproteins by an engineered alpha2-macroglobulin containing a furin recognition sequence in the bait region
Biochem J326, 507-514. PubMed Europe PubMed

1996

Denault,J.B. and Leduc,R.
Furin/PACE/SPC1: a convertase involved in exocytic and endocytic processing of precursor proteins
FEBS Lett379, 113-116. PubMed Europe PubMed DOI

1995

Brakch,N., Galanopoulou,A.S., Patel,Y.C., Boileau,G. and Seidah,N.G.
Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways
FEBS Lett362, 143-146. PubMed Europe PubMed DOI
De Bie,I., Savaria,D., Roebroek,A.J., Day,R., Lazure,C., Van de Ven,W.J. and Seidah,N.G.
Processing specificity and biosynthesis of the Drosophila melanogaster convertases dfurin1, dfurin1-CRR, dfurin1- X, and dfurin2
J Biol Chem270, 1020-1028. PubMed Europe PubMed DOI
Denault,J.B., D'Orleans-Juste,P., Masaki,T. and Leduc,R.
Inhibition of convertase-related processing of proendothelin-1
J Cardiovasc Pharmacol26 Suppl 3, S47-S50. PubMed Europe PubMed I
Garred,O., van Deurs,B. and Sandvig,K.
Furin-induced cleavage and activation of Shiga toxin
J Biol Chem270, 10817-10821. PubMed Europe PubMed DOI
Gordon,V.M., Klimpel,K.R., Arora,N., Henderson,M.A. and Leppla,S.H.
Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases
Infect Immun63, 82-87. PubMed Europe PubMed
[YEAR:21-4-1995]Hendy,G.N., Bennett,H.P., Gibbs,B.F., Lazure,C., Day,R. and Seidah,N.G.
Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study
J Biol Chem270, 9517-9525. PubMed Europe PubMed DOI
[YEAR:1-12-1995]Jones,B.G., Thomas,L., Molloy,S.S., Thulin,C.D., Fry,M.D., Walsh,K.A. and Thomas,G.
Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail
EMBO J14, 5869-5883. PubMed Europe PubMed
[YEAR:3-11-1995]Takahashi,S., Nakagawa,T., Kasai,K., Banno,T., Duguay,S.J., Van de Ven,W.J., Murakami,K. and Nakayama,K.
A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation
J Biol Chem270, 26565-26569. PubMed Europe PubMed DOI
Vey,M., Schafer,W., Reis,B., Ohuchi,R., Britt,W., Garten,W., Klenk,H.D. and Radsak,K.
Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediated by the human endoprotease furin
Virology206, 746-749. PubMed Europe PubMed DOI I

1994

[YEAR:25-3-1994]Ayoubi,T.A., Creemers,J.W., Roebroek,A.J. and Van de Ven,W.J.
Expression of the dibasic proprotein processing enzyme furin is directed by multiple promoters
J Biol Chem269, 9298-9303. PubMed Europe PubMed
Bravo,D.A., Gleason,J.B., Sanchez,R.I., Roth,R.A. and Fuller,R.S.
Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic parameters using the purified, secreted soluble protease expressed by a recombinant baculovirus
J Biol Chem269, 25830-25837. PubMed Europe PubMed P
Garten,W., Hallenberger,S., Ortmann,D., Schafer,W., Vey,M., Angliker,H., Shaw,E. and Klenk,H.D.
Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones
Biochimie76, 217-225. PubMed Europe PubMed I
[YEAR:1-1-1994]Molloy,S.S., Thomas,L., VanSlyke,J.K., Stenberg,P.E. and Thomas,G.
Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface
EMBO J13, 18-33. PubMed Europe PubMed
Nakayama,K.
Purification of recombinant soluble forms of furin produced in Chinese hamster ovary cells
Methods Enzymol244, 167-175. PubMed Europe PubMed DOI V
Walker,J.A., Molloy,S.S., Thomas,G., Sakaguchi,T., Yoshida,T., Chambers,T.M. and Kawaoka,Y.
Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus
J Virol68, 1213-1218. PubMed Europe PubMed

1993

Creemers,J.W., Siezen,R.J., Roebroek,A.J., Ayoubi,T.A., Huylebroeck,D. and Van de Ven,W.J.
Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis
J Biol Chem268, 21826-21834. PubMed Europe PubMed
Komada,M., Hatsuzawa,K., Shibamoto,S., Ito,F., Nakayama,K. and Kitamura,N.
Proteolytic processing of the hepatocyte growth factor/scatter factor receptor by furin
FEBS Lett328, 25-29. PubMed Europe PubMed DOI P
Torii,S., Yamagishi,T., Murakami,K. and Nakayama,K.
Localization of Kex2-like processing endoproteases, furin and PC4, within mouse testis by in situ hybridization
FEBS Lett316, 12-16. PubMed Europe PubMed DOI
Tsuneoka,M., Nakayama,K., Hatsuzawa,K., Komada,M., Kitamura,N. and Mekada,E.
Evidence for involvement of furin in cleavage and activation of diphtheria toxin
J Biol Chem268, 26461-26465. PubMed Europe PubMed
Wasley,L.C., Rehemtulla,A., Bristol,J.A. and Kaufman,R.J.
PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway
J Biol Chem268, 8458-8465. PubMed Europe PubMed

1992

Creemers,J.W., Roebroek,A.J. and Van de Ven,W.J.
Expression in human lung tumor cells of the proprotein processing enzyme PC1/PC3. Cloning and primary sequence of a 5 kb cDNA
FEBS Lett300, 82-88. PubMed Europe PubMed DOI
Hallenberger,S., Bosch,V., Angliker,H., Shaw,E., Klenk,H.D. and Garten,W.
Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160
Nature360, 358-361. PubMed Europe PubMed DOI I
Hatsuzawa,K., Murakami,K. and Nakayama,K.
Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg- Arg sites
J Biochem111, 296-301. PubMed Europe PubMed
Leduc,R., Molloy,S.S., Thorne,B.A. and Thomas,G.
Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage
J Biol Chem267, 14304-14308. PubMed Europe PubMed
Molloy,S.S., Bresnahan,P.A., Leppla,S.H., Klimpel,K.R. and Thomas,G.
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen
J Biol Chem267, 16396-16402. PubMed Europe PubMed
Seidah,N.G. and Chretien,M.
Proprotein and prohormone convertases of the subtilisin family. Recent developments and future perspectives
Trends Endocrinol Metab3, 133-140. PubMed Europe PubMed
Smeekens,S.P., Montag,A.G., Thomas,G., Albiges-Rizo,C., Carroll,R., Benig,M., Phillips,L.A., Martin,S., Ohagi,S., Gardner,P., Swift,H.H. and Steiner,D.F.
Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3
Proc Natl Acad Sci U S A89, 8822-8826. PubMed Europe PubMed
Steiner,D.F., Smeekens,S.P., Ohagi,S. and Chan,S.J.
The new enzymology of precursor processing endoproteases
J Biol Chem267, 23435-23438. PubMed Europe PubMed
Stieneke-Grober,A., Vey,M., Angliker,H., Shaw,E., Thomas,G., Roberts,C., Klenk,H.D. and Garten,W.
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease
EMBO J11, 2407-2414. PubMed Europe PubMed I
Vey,M., Orlich,M., Adler,S., Klenk,H.D., Rott,R. and Garten,W.
Hemagglutinin activation of pathogenic avian influenza viruses of serotype H7 requires the protease recognition motif R-X-K/R-R
Virology188, 408-413. PubMed Europe PubMed DOI

1991

Barr,P.J., Mason,O.B., Landsberg,K.E., Wong,P.A., Kiefer,M.C. and Brake,A.J.
cDNA and gene structure for a human subtilisin-like protease with cleavage specificity for paired basic amino acid residues
DNA Cell Biol10, 319-328. PubMed Europe PubMed
[YEAR:5-7-1991]Hosaka,M., Nagahama,M., Kim,W.S., Watanabe,T., Hatsuzawa,K., Ikemizu,J., Murakami,K. and Nakayama,K.
Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway
J Biol Chem266, 12127-12130. PubMed Europe PubMed
Misumi,Y., Oda,K., Fujiwara,T., Takami,N., Tashiro,K. and Ikehara,Y.
Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3
J Biol Chem266, 16954-16959. PubMed Europe PubMed
Oda,K., Ikeda,M., Tsuji,E., Sohda,M., Takami,N., Misumi,Y. and Ikehara,Y.
Sequence requirements for proteolytic cleavage of precursors with paired basic amino acids
Biochem Biophys Res Commun179, 1181-1186. PubMed Europe PubMed
Seidah,N.G., Mattei,M.G., Gaspar,L., Benjannet,S., Mbikay,M. and Chretien,M.
Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and Furin (mouse 7[D1- E2] region)
Genomics11, 103-107. PubMed Europe PubMed
Seidah,N.G., Day,R., Marcinkiewicz,M., Benjannet,S. and Chretien,M.
Mammalian neural and endocrine pro-protein and pro-hormone convertases belonging to the subtilisin family of serine proteinases
Enzyme45, 271-284. PubMed Europe PubMed
Van de Ven,W.J., Creemers,J.W. and Roebroek,A.J.
Furin: the prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway
Enzyme45, 257-270. PubMed Europe PubMed

1990

Bresnahan,P.A., Leduc,R., Thomas,L., Thorner,J., Gibson,H.L., Brake,A.J., Barr,P.J. and Thomas,G.
Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo
J Cell Biol111, 2851-2859. PubMed Europe PubMed DOI
Hatsuzawa,K., Hosaka,M., Nakagawa,T., Nagase,M., Shoda,A., Murakami,K. and Nakayama,K.
Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells
J Biol Chem265, 22075-22078. PubMed Europe PubMed
Misumi,Y., Sohda,M. and Ikehara,Y.
Sequence of the cDNA encoding rat furin, a possible propeptide- processing endoprotease
Nucleic Acids Res18, 6719-6719. PubMed Europe PubMed
[YEAR:31-8-1990]Misumi,Y., Ohkubo,K., Sohda,M., Takami,N., Oda,K. and Ikehara,Y.
Intracellular processing of complement pro-C3 and proalbumin is inhibited by rat alpha 1-protease inhibitor variant (Met352-->Arg) in transfected cells
Biochem Biophys Res Commun171, 236-242. PubMed Europe PubMed DOI
Van de Ven,W.J., Voorberg,J., Fontijn,R., Pannekoek,H., van den Ouweland,A.M., Van Duijnhoven,H.L., Roebroek,A.J. and Siezen,R.J.
Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes
Mol Biol Rep14, 265-275. PubMed Europe PubMed DOI
van den Ouweland,A.M.W., van Duijnhoven,H.L.P., Keizer,G.D., Dorssers,L.C.J. and Van de Ven,W.J.
Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2
Nucleic Acids Res18, 664-664. PubMed Europe PubMed DOI
Wise,R.J., Barr,P.J., Wong,P.A., Kiefer,M.C., Brake,A.J. and Kaufman,R.J.
Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site
Proc Natl Acad Sci U S A87, 9378-9382. PubMed Europe PubMed DOI

1986

Roebroek,A.J., Schalken,J.A., Bussemakers,M.J., van Heerikhuizen,H., Onnekink,C., Debruyne,F.M., Bloemers,H.P. and Van de Ven,W.J.
Characterization of human c-fes/fps reveals a new transcription unit (fur) in the immediately upstream region of the proto-oncogene
Mol Biol Rep11, 117-125. PubMed Europe PubMed DOI
Roebroek,A.J., Schalken,J.A., Leunissen,J.A., Onnekink,C., Bloemers,H.P. and Van de Ven,W.J.
Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein
EMBO J5, 2197-2202. PubMed Europe PubMed