PDBe 1p8j

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN

Released:

Function and Biology Details

Reaction catalysed:
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero octamer
hetero dimer
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Furin Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 471 amino acids
Theoretical weight: 51.15 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P23188 (Residues: 108-578; Coverage: 61%)
Gene names: Fur, Furin, Pcsk3
Sequence domains:
Structure domains:
DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE INHIBITOR Chains: J, K, L, M, N, P, Q, R
Molecule details ›
Chains: J, K, L, M, N, P, Q, R
Length: 6 amino acids
Theoretical weight: 749 Da
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P1
Unit cell:
a: 93.305Å b: 135.392Å c: 137.806Å
α: 103.56° β: 98.98° γ: 107.09°
R-values:
R R work R free
0.188 0.188 0.219
Expression systems:
  • Cricetulus griseus
  • Not provided