PDBe 4z2a

X-ray diffraction
1.89Å resolution

Crystal structure of unglycosylated apo human furin @1.89A

Released:
Source organism: Homo sapiens
Entry authors: Gampe RT, Pearce K, Reid R

Function and Biology Details

Reaction catalysed:
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Furin Chain: A
Molecule details ›
Chain: A
Length: 465 amino acids
Theoretical weight: 50.51 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P09958 (Residues: 110-574; Coverage: 61%)
Gene names: FUR, FURIN, PACE, PCSK3
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: C2
Unit cell:
a: 95.983Å b: 66.597Å c: 88.443Å
α: 90° β: 122.41° γ: 90°
R-values:
R R work R free
0.149 0.148 0.183
Expression system: Cricetulus griseus