PDBe 2w2m

X-ray diffraction
2.4Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Proprotein convertase subtilisin/kexin type 9 Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 33.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8NBP7 (Residues: 153-451; Coverage: 45%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Subtilase family
Structure domains: Peptidase S8/S53 domain
Low-density lipoprotein receptor Chain: E
Molecule details ›
Chain: E
Length: 107 amino acids
Theoretical weight: 12.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01130 (Residues: 314-393; Coverage: 10%)
Gene name: LDLR
Sequence domains: Complement Clr-like EGF-like
Structure domains: Laminin
Proprotein convertase subtilisin/kexin type 9 Chain: P
Molecule details ›
Chain: P
Length: 114 amino acids
Theoretical weight: 12.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8NBP7 (Residues: 53-152; Coverage: 15%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Peptidase inhibitor I9
Structure domains: Peptidase S8 propeptide/proteinase inhibitor I9

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P43212
Unit cell:
a: 83.004Å b: 83.004Å c: 211.566Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.215 0.254
Expression system: Escherichia coli BL21(DE3)