Structure for peptidase M02.001: angiotensin-converting enzyme peptidase unit 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
2C6F_A	Homo sapiens	3.01 Å	N-terminal catalytic domain only
The catalytic zinc atom is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: His390 and His394 in purple, and and Glu418 in dark blue. The catalytic Glu391 is shown in blue ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
mature peptidase	2.00 Å	1O8A	1O8A	1O8A	1O8A	1O8A	1O8A	Natesh et al., 2003
mature peptidase	1.82 Å	1UZE	1UZE	1UZE	1UZE	1UZE	1UZE	Natesh et al., 2004
mature peptidase	2.00 Å	1UZF	1UZF	1UZF	1UZF	1UZF	1UZF	Natesh et al., 2004
N-terminal catalytic domain only	3.01 Å	2C6F	2C6F	2C6F	2C6F	2C6F	2C6F	Corradi et al., 2006
mature peptidase	3.00 Å	2C6N	2C6N	2C6N	2C6N	2C6N	2C6N	Corradi et al., 2006
mature peptidase	2.01 Å	2IUL	2IUL	2IUL	2IUL	2IUL	2IUL	Watermeyer et al., 2006
mature peptidase	2.80 Å	2IUX	2IUX	2IUX	2IUX	2IUX	2IUX	Watermeyer et al., 2006
mature peptidase	1.97 Å	2XY9	2XY9	2XY9	2XY9	2XY9	2XY9	Akif et al., 2011
mature peptidase	2.15 Å	2XYD	2XYD	2XYD	2XYD	2XYD	2XYD	Akif et al., 2011
mature peptidase	2.44 Å	2YDM	2YDM	2YDM	2YDM	2YDM	2YDM	Akif et al., 2011
testis ace co-crystal structure with ketone ace inhibitor kaf	2.17 Å	3BKK	3BKK	3BKK	3BKK	3BKK	3BKK	Watermeyer et al., 2008
testis ace co-crystal structure with ketone ace inhibitor kaw	2.18 Å	3BKL	3BKL	3BKL	3BKL	3BKL	3BKL	Watermeyer et al., 2008
mature peptidase	2.30 Å	3L3N	3L3N	3L3N	3L3N	3L3N	3L3N	Watermeyer et al., 2010
mature peptidase	1.99 Å	3NXQ	3NXQ	3NXQ	3NXQ	3NXQ	3NXQ	Anthony et al., 2010
mature peptidase	1.99 Å	4APH	4APH	4APH	4APH	4APH	4APH	Masuyer et al., 2012
mature peptidase	2.60 Å	4APJ	4APJ	4APJ	4APJ	4APJ	4APJ	Masuyer et al., 2012
mature peptidase	2.20 Å	4BXK	4BXK	4BXK	4BXK	4BXK	4BXK	Douglas et al., 2014
mature peptidase	1.84 Å	4BZR	4BZR	4BZR	4BZR	4BZR	4BZR	Kramer et al., 2014
mature peptidase	2.10 Å	4BZS	4BZS	4BZS	4BZS	4BZS	4BZS	Kramer et al., 2014
mature peptidase	2.59 Å	4C2N	4C2N	4C2N	4C2N	4C2N	4C2N	Yates et al., 2014
mature peptidase	1.80 Å	4C2O	4C2O	4C2O	4C2O	4C2O	4C2O	Yates et al., 2014
mature peptidase	1.99 Å	4C2P	4C2P	4C2P	4C2P	4C2P	4C2P	Yates et al., 2014
mature peptidase	2.40 Å	4C2Q	4C2Q	4C2Q	4C2Q	4C2Q	4C2Q	Yates et al., 2014
mature peptidase	2.30 Å	4C2R	4C2R	4C2R	4C2R	4C2R	4C2R
mature peptidase	1.85 Å	4CA5	4CA5	4CA5	4CA5	4CA5	4CA5	Masuyer et al., 2014
mature peptidase	1.91 Å	4CA6	4CA6	4CA6	4CA6	4CA6	4CA6	Masuyer et al., 2014
mature peptidase	1.80 Å	4UFA	4UFA	4UFA	4UFA	4UFA	4UFA	Masuyer et al., 2015
mature peptidase	1.80 Å	4UFB	4UFB	4UFB	4UFB	4UFB	4UFB	Masuyer et al., 2015
N-domain; complex with amyloid-beta 4-10	1.90 Å	5AM8	5AM8	5AM8	5AM8	5AM8	5AM8
N-domain; complex with amyloid-beta 10-16	1.80 Å	5AM9	5AM9	5AM9	5AM9	5AM9	5AM9
N-domain; complex with amyloid-beta 1-16	1.80 Å	5AMA	5AMA	5AMA	5AMA	5AMA	5AMA
N-domain; complex with amyloid-beta 35-42	1.55 Å	5AMB	5AMB	5AMB	5AMB	5AMB	5AMB
N-domain; complex with amyloid-beta fluorogenic fragment 4-10	1.65 Å	5AMC	5AMC	5AMC	5AMC	5AMC	5AMC
N-domain; complex with a diprolyl inhibitor.	1.75 Å	6EN5	6EN5	6EN5	6EN5	6EN5	6EN5
N-domain; complex with a diprolyl inhibitor.	1.80 Å	6EN6	6EN6	6EN6	6EN6	6EN6	6EN6
N-domain; complex with sampatrilat-asp.	1.85 Å	6F9R	6F9R	6F9R	6F9R	6F9R	6F9R
complex with sampatrilat.	1.60 Å	6F9T	6F9T	6F9T	6F9T	6F9T	6F9T
complex with sampatrilat-asp.	1.90 Å	6F9U	6F9U	6F9U	6F9U	6F9U	6F9U
N-domain; complex with sampatrilat.	1.69 Å	6F9V	6F9V	6F9V	6F9V	6F9V	6F9V
C-domain complex with omapatrilat.	1.37 Å	6H5W	6H5W	6H5W	6H5W	6H5W	6H5W
N-domain; complex with omapatrilat.	1.80 Å	6H5X	6H5X	6H5X	6H5X	6H5X	6H5X
N-domain; complex with bppb	1.80 Å	6QS1	6QS1	6QS1	6QS1	6QS1	6QS1