| Activity |
|---|
| Catalytic type | Metallo |
| Peplist | Included in the Peplist with identifier PL00132 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.15 (Peptidyl-dipeptidases) >> Peptidase 3.4.15.1
|
| Enzymology | BRENDA database |
| Activity status | human: active (Araujo et al., 2000)
mouse: active (Vazeux et al., 2001)
|
| Physiology | This is peptidase unit 1 of two peptidase units in the somatic form of angiotensin-converting enzyme. Angiotensin-converting enzyme is an ectoenzyme active in conversion of angiotensin I to hypertensive angiotensin II, and degradation of bradykinin and other bioactive peptides. An insertion/deletion polymorphism is associated with left ventricular hypertrophy. |
| Knockout | Esther et al. (1997) used targeted homologous recombination to create mice expressing a form of the enzyme that contains only peptidase unit 1. The modified enzyme was catalytically active but entirely secreted from cells. Mice had significant plasma activity but no tissue-bound enzyme. They had low blood pressure, renal vascular thickening, and a urine concentrating defect, and were very similar to completely deficient mice (Esther et al., 1996) except that the renal pathology was less severe. |
| Pharmaceutical relevance | The somatic form of angiotensin-converting enzyme containing this peptidase unit together with peptidase unit 2 (M02.004) is a drug target for the control of hypertension. |
|
Other databases
| PANTHER | http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR10514:SF25 |
