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Literature for peptidase M02.001: angiotensin-converting enzyme peptidase unit 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Hanak,F., Swanson,J.L., Felczak,K., Bernstein,K.E., More,S.S. and Rothwell,P.E.
    Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue
    bioRxiv PubMed  Europe PubMed DOI
    2. 2023
  2. da Agostini,L., Cunha,W.R., Silva,N.N.T., Melo,A.S., Moreira,L.B., Almeida,T.C., Belo,V.A., Coura-Vital,W., de,M.T., Lima,A.A. and da Silva,G.N.
    Angiotensin-converting enzyme gene (ACE) polymorphisms are associated with dysregulation of biochemical parameters in hypertensive patients
    Mol Biol Rep50, 1487-1497. PubMed  Europe PubMed DOI
    3. 2019
  3. Sturrock,E.D., Lubbe,L., Cozier,G.E., Schwager,S.L.U., Arowolo,A.T., Arendse,L.B., Belcher,E. and Acharya,K.R.
    Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb)
    Biochem J476, 1553-1570. PubMed  Europe PubMed DOI  I
    4. 2018
  4. Cozier,G.E., Schwager,S.L., Sharma,R.K., Chibale,K., Sturrock,E.D. and Acharya,K.R.
    Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE - a molecular basis for domain selectivity
    FEBS J285, 1477-1490. PubMed  Europe PubMed DOI  S  I
  5. Cozier,G.E., Arendse,L.B., Schwager,S.L., Sturrock,E.D. and Acharya,K.R.
    Molecular basis for multiple omapatrilat binding sites within the ACE C-domain: implications for drug design
    J Med Chem61, 10141-10154. PubMed  Europe PubMed DOI  I
  6. Fienberg,S., Cozier,G.E., Acharya,K.R., Chibale,K. and Sturrock,E.D.
    The design and development of a potent and selective novel diprolyl derivative that binds to the N-domain of angiotensin-I converting enzyme
    J Med Chem61, 344-359. PubMed  Europe PubMed DOI  S  I
  7. Kugaevskaya,E.V., Veselovsky,A.V., Indeykina,M.I., Solovyeva,N.I., Zharkova,M.S., Popov,I.A., Nikolaev,E.N., Mantsyzov,A.B., Makarov,A.A. and Kozin,S.A.
    N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-beta(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease
    Sci Rep8, 298-298. PubMed  Europe PubMed DOI
    8. 2016
  8. Larmuth,K.M., Masuyer,G., Douglas,R.G., Schwager,S.L., Acharya,K.R. and Sturrock,E.D.
    Kinetic and structural characterization of amyloid-beta peptide hydrolysis by human angiotensin-1-converting enzyme
    FEBS J283, 1060-1076. PubMed  Europe PubMed DOI  S
  9. Mu,X., Zhang,C. and Xu,D.
    QM/MM investigation of the catalytic mechanism of angiotensin-converting enzyme
    J Mol Model22, 132-132. PubMed  Europe PubMed DOI
    10. 2015
  10. Masuyer,G., Douglas,R.G., Sturrock,E.D. and Acharya,K.R.
    Structural basis of Ac-SDKP hydrolysis by angiotensin-I converting enzyme
    Sci Rep5, 13742-13742. PubMed  Europe PubMed DOI  S
    11. 2014
  11. Danilov,S.M., Wade,M.S., Schwager,S.L., Douglas,R.G., Nesterovitch,A.B., Popova,I.A., Hogarth,K.D., Bhardwaj,N., Schwartz,D.E., Sturrock,E.D. and Garcia,J.G.
    A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP
    PLoS ONE9, e88001-e88001. PubMed  Europe PubMed DOI  M
  12. Douglas,R.G., Sharma,R.K., Masuyer,G., Lubbe,L., Zamora,I., Acharya,K.R., Chibale,K. and Sturrock,E.D.
    Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors
    Clin Sci (Lond)126, 305-313. PubMed  Europe PubMed DOI  I
  13. Kramer,G.J., Mohd,A., Schwager,S.L.U., Masuyer,G., Acharya,K.R., Sturrock,E.D. and Bachmann,B.O.
    Interkingdom pharmacology of angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes
    ACS Med Chem Lett5, 346-351. PubMed  Europe PubMed DOI  S  I
  14. Masuyer,G., Akif,M., Czarny,B., Beau,F., Schwager,S.L., Sturrock,E.D., Isaac,R.E., Dive,V. and Acharya,K.R.
    Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme
    FEBS J281, 943-956. PubMed  Europe PubMed DOI  S  I
  15. Yates,C.J., Masuyer,G., Schwager,S.L., Akif,M., Sturrock,E.D. and Acharya,K.R.
    Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE)
    J Biol Chem289, 1798-1814. PubMed  Europe PubMed DOI  S
    16. 2013
  16. Hocharoen,L., Joyner,J.C. and Cowan,J.A.
    N- versus C-domain selectivity of catalytic inactivation of human angiotensin converting enzyme by lisinopril-coupled transition metal chelates
    J Med Chem56, 9826-9836. PubMed  Europe PubMed DOI  I
    17. 2012
  17. Bersanetti,P.A., Sabatini,R.A., Matos,B.S., Douglas,R.G., Nchinda,A., Juliano,M.A., Pesquero,J.B., Sturrock,E.D. and Carmona,A.K.
    Characterization of angiotensin I-converting enzyme N-domain selectivity using positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides
    Biol Chem393, 1547-1554. PubMed  Europe PubMed DOI  P
  18. Masuyer,G., Schwager,S.L., Sturrock,E.D., Isaac,R.E. and Acharya,K.R.
    Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides
    Sci Rep2, 717-717. PubMed  Europe PubMed DOI  I
  19. Ong,F.S., Lin,C.X., Campbell,D.J., Okwan-Duodu,D., Chen,X., Blackwell,W.L., Shah,K.H., Gonzalez-Villalobos,R.A., Shen,X.Z., Fuchs,S. and Bernstein,K.E.
    Increased angiotensin II-induced hypertension and inflammatory cytokines in mice lacking angiotensin-converting enzyme N domain activity
    Hypertension59, 283-290. PubMed  Europe PubMed DOI
  20. Sharma,R.K., Douglas,R.G., Louw,S., Chibale,K. and Sturrock,E.D.
    New ketomethylene inhibitor analogues: synthesis and assessment of structural determinants for N-domain selective inhibition of angiotensin-converting enzyme
    Biol Chem393, 485-493. PubMed  Europe PubMed DOI  I
  21. Sturrock,E.D., Anthony,C.S. and Danilov,S.M.
    Peptidyl-dipeptidase A/angiotensin I-converting enzyme
    [ISSN:978-0-12-407744-7]3, 480-494. DOI
    22. 2011
  22. Akif,M., Schwager,S.L., Anthony,C.S., Czarny,B., Beau,F., Dive,V., Sturrock,E.D. and Acharya,K.R.
    Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide
    Biochem J436, 53-59. PubMed  Europe PubMed DOI  S  I
  23. Bernstein,K.E., Shen,X.Z., Gonzalez-Villalobos,R.A., Billet,S., Okwan-Duodu,D., Ong,F.S. and Fuchs,S.
    Different in vivo functions of the two catalytic domains of angiotensin-converting enzyme (ACE)
    Curr Opin Pharmacol11, 105-111. PubMed  Europe PubMed DOI
    24. 2010
  24. Anthony,C.S., Corradi,H.R., Schwager,S.L., Redelinghuys,P., Georgiadis,D., Dive,V., Acharya,K.R. and Sturrock,E.D.
    The N domain of human angiotensin-I-converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407
    J Biol Chem285, 35685-35693. PubMed  Europe PubMed DOI  S  I
  25. Gordon,K., Balyasnikova,I.V., Nesterovitch,A.B., Schwartz,D.E., Sturrock,E.D. and Danilov,S.M.
    Fine epitope mapping of monoclonal antibodies 9B9 and 3G8 to the N domain of angiotensin-converting enzyme (CD143) defines a region involved in regulating angiotensin-converting enzyme dimerization and shedding
    Tissue Antigens75, 136-150. PubMed  Europe PubMed DOI
  26. Li,P., Xiao,H.D., Xu,J., Ong,F.S., Kwon,M., Roman,J., Gal,A., Bernstein,K.E. and Fuchs,S.
    Angiotensin-converting enzyme N-terminal inactivation alleviates bleomycin-induced lung injury
    Am J Pathol177, 1113-1121. PubMed  Europe PubMed DOI  K  I
  27. Spyranti,Z., Galanis,A.S., Pairas,G., Spyroulias,G.A., Manessi-Zoupa,E. and Cordopatis,P.
    Synthetic peptides as structural maquettes of angiotensin-I converting enzyme catalytic sites
    Bioinorg Chem Appl820476-820476. PubMed  Europe PubMed DOI
  28. Sun,X., Rentzsch,B., Gong,M., Eichhorst,J., Pankow,K., Papsdorf,G., Maul,B., Bader,M. and Siems,W.E.
    Signal transduction in CHO cells stably transfected with domain-selective forms of murine ACE
    Biol Chem391, 235-244. PubMed  Europe PubMed DOI
  29. Watermeyer,J., Kroger,W.L., Sturrock,E.D. and Ehlers,M.R.
    Angiotensin-converting enzyme - new insights into structure, biological significance and prospects for domain-selective inhibitors
    Curr Enzyme Inhib5, 134-147.
    30. 2009
  30. Kroger,W.L., Douglas,R.G., O'Neill,H.G., Dive,V. and Sturrock,E.D.
    Investigating the domain specificity of phosphinic inhibitors RXPA380 and RXP407 in angiotensin-converting enzyme
    Biochemistry48, 8405-8412. PubMed  Europe PubMed DOI  I
  31. Zou,K., Maeda,T., Watanabe,A., Liu,J., Liu,S., Oba,R., Satoh,Y., Komano,H. and Michikawa,M.
    Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme
    J Biol Chem284, 31914-31920. PubMed  Europe PubMed DOI
    32. 2008
  32. Danilov,S.M., Balyasnikova,I.V., Albrecht,R.F. and Kost,O.A.
    Simultaneous determination of ACE activity with 2 substrates provides information on the status of somatic ACE and allows detection of inhibitors in human blood
    J Cardiovasc Pharmacol52, 90-103. PubMed  Europe PubMed DOI  A
  33. O'Neill,H.G., Redelinghuys,P., Schwager,S.L. and Sturrock,E.D.
    The role of glycosylation and domain interactions in the thermal stability of human angiotensin-converting enzyme
    Biol Chem389, 1153-1161. PubMed  Europe PubMed DOI
  34. Rushworth,C.A., Guy,J.L. and Turner,A.J.
    Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis
    FEBS J275, 6033-6042. PubMed  Europe PubMed DOI  I
  35. Toropygin,I.Y., Kugaevskaya,E.V., Mirgorodskaya,O.A., Elisseeva,Y.E., Kozmin,Y.P., Popov,I.A., Nikolaev,E.N., Makarov,A.A. and Kozin,S.A.
    The N-domain of angiotensin-converting enzyme specifically hydrolyzes the Arg-5-His-6 bond of Alzheimer's Abeta-(1-16) peptide and its isoAsp-7 analogue with different efficiency as evidenced by quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Rapid Commun Mass Spectrom22, 231-239. PubMed  Europe PubMed DOI
  36. Watermeyer,J.M., Kroger,W.L., O'Neill,H.G., Sewell,B.T. and Sturrock,E.D.
    Probing the basis of domain-dependent inhibition using novel ketone inhibitors of angiotensin-converting enzyme
    Biochemistry47, 5942-5950. PubMed  Europe PubMed DOI  I
    37. 2007
  37. Balyasnikova,I.V., Skirgello,O.E., Binevski,P.V., Nesterovitch,A.B., Albrecht,R.F., Kost,O.A. and Danilov,S.M.
    Monoclonal antibodies 1G12 and 6A12 to the N-domain of human angiotensin-converting enzyme: fine epitope mapping and antibody-based detection of ACE inhibitors in human blood
    J Proteome Res6, 1580-1594. PubMed  Europe PubMed DOI
  38. Danilov,S.M., Watermeyer,J.M., Balyasnikova,I.V., Gordon,K., Kugaevskaya,E.V., Elisseeva,Y.E., Albrecht,R.F. and Sturrock,E.D.
    Fine epitope mapping of monoclonal antibody 5F1 reveals anticatalytic activity toward the N domain of human angiotensin-converting enzyme
    Biochemistry46, 9019-9031. PubMed  Europe PubMed DOI
  39. Vamvakas,S.S., Leondiadis,L., Pairas,G., Manessi-Zoupa,E., Spyroulias,G.A. and Cordopatis,P.
    Expression, purification, and physicochemical characterization of the N-terminal active site of human angiotensin-I converting enzyme
    J Pept Sci13, 31-36. PubMed  Europe PubMed DOI  E
    40. 2006
  40. [YEAR:19-12-2006]Bernstein,K.E.
    Views of the renin-angiotensin system: brilling, mimsy, and slithy tove
    Hypertension47, 509-514. PubMed  Europe PubMed DOI  V
  41. Carmona,A.K., Schwager,S.L., Juliano,M.A., Juliano,L. and Sturrock,E.D.
    A continuous fluorescence resonance energy transfer angiotensin I-converting enzyme assay
    Nat Protoc1, 1971-1976. PubMed  Europe PubMed DOI  A
  42. Corradi,H.R., Schwager,S.L., Nchinda,A.T., Sturrock,E.D. and Acharya,K.R.
    Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design
    J Mol Biol357, 964-974. PubMed  Europe PubMed DOI  S  T  I
  43. Kohlstedt,K., Gershome,C., Friedrich,M., Muller-Esterl,W., Alhenc-Gelas,F., Busse,R. and Fleming,I.
    Angiotensin-converting enzyme (ACE) dimerization is the initial step in the ACE inhibitor-induced ACE signaling cascade in endothelial cells
    Mol Pharmacol69, 1725-1732. PubMed  Europe PubMed DOI
  44. [YEAR:13-3-2006]Kugaevskaya,E.V., Kolesanova,E.F., Kozin,S.A., Veselovsky,A.V., Dedinsky,I.R. and Elisseeva,Y.E.
    Epitope mapping of the domains of human angiotensin converting enzyme
    Biochim Biophys Acta1760, 959-965. PubMed  Europe PubMed DOI
  45. [YEAR:18-4-2006]Skirgello,O.E., Balyasnikova,I.V., Binevski,P.V., Sun,Z.L., Baskin,I.I., Palyulin,V.A., Nesterovitch,A.B., Albrecht,R.F., Kost,O.A. and Danilov,S.M.
    Inhibitory antibodies to human angiotensin-converting enzyme: fine epitope mapping and mechanism of action
    Biochemistry45, 4831-4847. PubMed  Europe PubMed DOI
    46. 2005
  46. Alves,M.F., Araujo,M.C., Juliano,M.A., Oliveira,E.M., Krieger,J.E., Casarini,D.E., Juliano,L. and Carmona,A.K.
    A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity
    Braz J Med Biol Res38, 861-868. PubMed  Europe PubMed DOI  A
  47. Balyasnikova,I.V., Woodman,Z.L., Albrecht,R.F., Natesh,R., Acharya,K.R., Sturrock,E.D. and Danilov,S.M.
    Localization of an N-domain region of angiotensin-converting enzyme involved in the regulation of ectodomain shedding using monoclonal antibodies
    J Proteome Res4, 258-267. PubMed  Europe PubMed DOI
  48. Redelinghuys,P., Nchinda,A.T. and Sturrock,E.D.
    Development of domain-selective angiotensin I-converting enzyme inhibitors
    Ann N Y Acad Sci1056, 160-175. PubMed  Europe PubMed DOI  V
  49. [YEAR:1-8-2005]Woodman,Z.L., Schwager,S.L., Redelinghuys,P., Carmona,A.K., Ehlers,M.R. and Sturrock,E.D.
    The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity
    Biochem J389, 739-744. PubMed  Europe PubMed DOI
    50. 2004
  50. Corvol,P., Eyries,M. and Soubrier,F.
    Peptidyl-dipeptidase A/angiotensin I-converting enzyme
    [ISSN:0-12-079610-4]2, 332-346.  V
  51. [YEAR:16-4-2004]Fuchs,S., Xiao,H.D., Cole,J.M., Adams,J.W., Frenzel,K., Michaud,A., Zhao,H., Keshelava,G., Capecchi,M.R., Corvol,P. and Bernstein,K.E.
    Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice
    J Biol Chem279, 15946-15953. PubMed  Europe PubMed DOI
  52. Inguimbert,N., Poras,H., Dhotel,H., Beslot,F., Scalbert,E., Bennejean,C., Renard,P., Fournie-Zaluski,M.C. and Roques,B.P.
    In vivo properties of thiol inhibitors of the three vasopeptidases NEP, ACE and ECE are improved by introduction of a 7-azatryptophan in P2' position
    J Pept Res63, 99-107. PubMed  Europe PubMed DOI  I
  53. Spyroulias,G.A., Galanis,A.S., Pairas,G., Manessi-Zoupa,E. and Cordopatis,P.
    Structural features of angiotensin-I converting enzyme catalytic sites: conformational studies in solution, homology models and comparison with other zinc metallopeptidases
    Curr Top Med Chem4, 403-429. PubMed  Europe PubMed DOI
  54. Sturrock,E.D., Natesh,R., van Rooyen,J.M. and Acharya,K.R.
    Structure of angiotensin I-converting enzyme
    Cell Mol Life Sci61, 2677-2686. PubMed  Europe PubMed DOI  V  S  I
    55. 2003
  55. [YEAR:28-8-2003]Binevski,P.V., Sizova,E.A., Pozdnev,V.F. and Kost,O.A.
    Evidence for the negative cooperativity of the two active sites within bovine somatic angiotensin-converting enzyme
    FEBS Lett550, 84-88. PubMed  Europe PubMed DOI  I
  56. [YEAR:22-8-2003]Fernandez,J.H., Hayashi,M.A., Camargo,A.C. and Neshich,G.
    Structural basis of the lisinopril-binding specificity in N- and C-domains of human somatic ACE
    Biochem Biophys Res Commun308, 219-226. PubMed  Europe PubMed DOI
  57. Marques,G.D., Quinto,B.M., Plavinik,F.L., Krieger,J.E., Marson,O. and Casarini,D.E.
    N-domain angiotensin I-converting enzyme with 80 kDa as a possible genetic marker of hypertension
    Hypertension42, 693-701. PubMed  Europe PubMed DOI
  58. Tzakos,A.G., Galanis,A.S., Spyroulias,G.A., Cordopatis,P., Manessi-Zoupa,E. and Gerothanassis,I.P.
    Structure-function discrimination of the N- and C- catalytic domains of human angiotensin-converting enzyme: implications for Cl- activation and peptide hydrolysis mechanisms
    Protein Eng16, 993-1003. PubMed  Europe PubMed DOI
    59. 2002
  59. Voronov,S., Zueva,N., Orlov,V., Arutyunyan,A. and Kost,O.
    Temperature-induced selective death of the C-domain within angiotensin-converting enzyme molecule
    FEBS Lett522, 77-82. PubMed  Europe PubMed DOI
    60. 2001
  60. Junot,C., Gonzales,M.F., Ezan,E., Cotton,J., Vazeux,G., Michaud,A., Azizi,M., Vassiliou,S., Yiotakis,A., Corvol,P. and Dive,V.
    RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis
    J Pharmacol Exp Ther297, 606-611. PubMed  Europe PubMed  I
  61. Menard,J. and Patchett,A.A.
    Angiotensin-converting enzyme inhibitors
    Adv Protein Chem56, 13-75. PubMed  Europe PubMed DOI  V  I
  62. [YEAR:1-4-2001]Vazeux,G., Cotton,J., Cuniasse,P. and Dive,V.
    Potency and selectivity of RXP407 on human, rat, and mouse angiotensin-converting enzyme
    Biochem Pharmacol61, 835-841. PubMed  Europe PubMed DOI  I
    63. 2000
  63. [YEAR:25-7-2000]Araujo,M.C., Melo,R.L., Cesari,M.H., Juliano,M.A., Juliano,L. and Carmona,A.K.
    Peptidase specificity characterization of C- and N-terminal catalytic sites of angiotensin I-converting enzyme
    Biochemistry39, 8519-8525. PubMed  Europe PubMed DOI
  64. Azizi,M., Massien,C., Michaud,A. and Corvol,P.
    In vitro and in vivo inhibition of the 2 active sites of ACE by omapatrilat, a vasopeptidase inhibitor
    Hypertension35, 1226-1231. PubMed  Europe PubMed  I
  65. Binevski,P.V., Nikolskaya,I.I., Pozdnev,V.F. and Kost,O.A.
    Isolation and characterization of the N-domain of bovine angiotensin-converting enzyme
    Biochemistry (Mosc)65, 651-658. PubMed  Europe PubMed
  66. [YEAR:10-4-2000]Cheviron,N., Rousseau-Plasse,A., Lenfant,M., Adeline,M.T., Potier,P. and Thierry,J.
    Coumarin-Ser-Asp-Lys-Pro-OH, a fluorescent substrate for determination of angiotensin-converting enzyme activity via high-performance liquid chromatography
    Anal Biochem280, 58-64. PubMed  Europe PubMed DOI  A
  67. [YEAR:1-8-2000]Coates,D., Isaac,R.E., Cotton,J., Siviter,R., Williams,T.A., Shirras,A., Corvol,P. and Dive,V.
    Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme
    Biochemistry39, 8963-8969. PubMed  Europe PubMed DOI  I
  68. [YEAR:25-8-2000]Kessler,S.P., Rowe,T.M., Gomos,J.B., Kessler,P.M. and Sen,G.C.
    Physiological non-equivalence of the two isoforms of angiotensin-converting enzyme
    J Biol Chem275, 26259-26264. PubMed  Europe PubMed DOI
  69. Ortiz-Salmeron,E., Baron,C. and Garcia-Fuentes,L.
    Separation and purification of N-domain of bovine lung angiotensin I-converting enzyme by size exclusion chromatography
    J Liq Chromatogr Relat Technol23, 1499-1510. DOI
    70. 1999
  70. Araujo,M.C., Melo,R.I., Del Nery,E., Alves,M.F., Juliano,M.A., Casarini,D.E., Juliano,L. and Carmona,A.K.
    Internally quenched fluorogenic substrates for angiotensin I-converting enzyme
    J Hypertens17, 665-672. PubMed  Europe PubMed DOI  A
  71. [YEAR:13-4-1999]Dive,V., Cotton,J., Yiotakis,A., Michaud,A., Vassiliou,S., Jiracek,J., Vazeux,G., Chauvet,M.T., Cuniasse,P. and Corvol,P.
    RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites
    Proc Natl Acad Sci U S A96, 4330-4335. PubMed  Europe PubMed DOI  I
  72. Junot,C., Menard,J., Gonzales,M.F., Michaud,A., Corvol,P. and Ezan,E.
    In vivo assessment of captopril selectivity of angiotensin I-converting enzyme inhibition: differential inhibition of acetyl-Ser-Asp-Lys-Pro and angiotensin I hydrolysis
    J Pharmacol Exp Ther289, 1257-1261. PubMed  Europe PubMed  I
  73. [YEAR:15-3-1999]Michaud,A., Chauvet,M.T. and Corvol,P.
    N-domain selectivity of angiotensin I-converting enzyme as assessed by structure-function studies of its highly selective substrate, N-acetyl-seryl-aspartyl-lysyl-proline
    Biochem Pharmacol57, 611-618. PubMed  Europe PubMed DOI
    74. 1998
  74. Deddish,P.A., Marcic,B., Jackman,H.L., Wang,H.Z., Skidgel,R.A. and Erdos,E.G.
    N-domain-specific substrate and C-domain inhibitors of angiotensin-converting enzyme: angiotensin-(1-7) and keto-ACE
    Hypertension31, 912-917. PubMed  Europe PubMed  I
    75. 1997
  75. Deddish,P.A., Jackman,H.L., Skidgel,R.A. and Erdos,E.G.
    Differences in the hydrolysis of enkephalin congeners by the two domains of angiotensin converting enzyme
    Biochem Pharmacol53, 1459-1463. PubMed  Europe PubMed DOI
  76. Esther,C.R., Marino,E.M., Howard,T.E., Machaud,A., Corvol,P., Capecchi,M.R. and Bernstein,K.E.
    The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice
    J Clin Invest99, 2375-2385. PubMed  Europe PubMed DOI  K
  77. Hayakari,M., Satoh,K., Ookawa,K., Kano,H., Murakami,S., Ikeda,N. and Tsuchida,S.
    Kinetic evaluation of beta-neoendorphin hydrolysis by the somatic and testicular isozymes of human angiotensin-converting enzyme
    Biochim Biophys Acta1339, 31-38. PubMed  Europe PubMed DOI
  78. Michaud,A., Williams,T.A., Chauvet,M.T. and Corvol,P.
    Substrate dependence of angiotensin I-converting enzyme inhibition: captopril displays a partial selectivity for inhibition of N-acetyl-seryl-aspartyl-lysyl-proline hydrolysis compared with that of angiotensin I
    Mol Pharmacol51, 1070-1076. PubMed  Europe PubMed  I
  79. Sturrock,E.D., Danilov,S.M. and Riordan,J.F.
    Limited proteolysis of human kidney angiotensin-converting enzyme and generation of catalytically active N- and C-terminal domains
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