Literature for peptidase M02.001: angiotensin-converting enzyme peptidase unit 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Hanak,F., Swanson,J.L., Felczak,K., Bernstein,K.E., More,S.S. and Rothwell,P.E. Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC
Hanak,F., Swanson,J.L., Felczak,K., Dobariya,P., Girdwood,U.C., Bernstein,K.E., More,S.S. and Rothwell,P.E. Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue JCI Insight (2025) PubMed Europe PubMed DOI

2023

da Agostini,L., Cunha,W.R., Silva,N.N.T., Melo,A.S., Moreira,L.B., Almeida,T.C., Belo,V.A., Coura-Vital,W., de,M.T., Lima,A.A. and da Silva,G.N. Angiotensin-converting enzyme gene (ACE) polymorphisms are associated with dysregulation of biochemical parameters in hypertensive patients Mol Biol Rep (2023) 50, 1487-1497. PubMed Europe PubMed DOI

2019

Sturrock,E.D., Lubbe,L., Cozier,G.E., Schwager,S.L.U., Arowolo,A.T., Arendse,L.B., Belcher,E. and Acharya,K.R. Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb) Biochem J (2019) 476, 1553-1570. PubMed Europe PubMed DOI I

2018

Cozier,G.E., Arendse,L.B., Schwager,S.L., Sturrock,E.D. and Acharya,K.R. Molecular basis for multiple omapatrilat binding sites within the ACE C-domain: implications for drug design J Med Chem (2018) 61, 10141-10154. PubMed Europe PubMed DOI I
Cozier,G.E., Schwager,S.L., Sharma,R.K., Chibale,K., Sturrock,E.D. and Acharya,K.R. Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE - a molecular basis for domain selectivity FEBS J (2018) 285, 1477-1490. PubMed Europe PubMed DOI PMC EPMC S I
Fienberg,S., Cozier,G.E., Acharya,K.R., Chibale,K. and Sturrock,E.D. The design and development of a potent and selective novel diprolyl derivative that binds to the N-domain of angiotensin-I converting enzyme J Med Chem (2018) 61, 344-359. PubMed Europe PubMed DOI S I
Kugaevskaya,E.V., Veselovsky,A.V., Indeykina,M.I., Solovyeva,N.I., Zharkova,M.S., Popov,I.A., Nikolaev,E.N., Mantsyzov,A.B., Makarov,A.A. and Kozin,S.A. N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-beta(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease Sci Rep (2018) 8, 298-298. PubMed Europe PubMed DOI PMC EPMC

2016

Larmuth,K.M., Masuyer,G., Douglas,R.G., Schwager,S.L., Acharya,K.R. and Sturrock,E.D. Kinetic and structural characterization of amyloid-beta peptide hydrolysis by human angiotensin-1-converting enzyme FEBS J (2016) 283, 1060-1076. PubMed Europe PubMed DOI S
Mu,X., Zhang,C. and Xu,D. QM/MM investigation of the catalytic mechanism of angiotensin-converting enzyme J Mol Model (2016) 22, 132-132. PubMed Europe PubMed DOI

2015

Masuyer,G., Douglas,R.G., Sturrock,E.D. and Acharya,K.R. Structural basis of Ac-SDKP hydrolysis by angiotensin-I converting enzyme Sci Rep (2015) 5, 13742-13742. PubMed Europe PubMed DOI PMC EPMC S

2014

Danilov,S.M., Wade,M.S., Schwager,S.L., Douglas,R.G., Nesterovitch,A.B., Popova,I.A., Hogarth,K.D., Bhardwaj,N., Schwartz,D.E., Sturrock,E.D. and Garcia,J.G. A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP PLoS ONE (2014) 9, e88001-e88001. PubMed Europe PubMed DOI PMC EPMC M
Douglas,R.G., Sharma,R.K., Masuyer,G., Lubbe,L., Zamora,I., Acharya,K.R., Chibale,K. and Sturrock,E.D. Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors Clin Sci (Lond) (2014) 126, 305-313. PubMed Europe PubMed DOI I
Kramer,G.J., Mohd,A., Schwager,S.L.U., Masuyer,G., Acharya,K.R., Sturrock,E.D. and Bachmann,B.O. Interkingdom pharmacology of angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes ACS Med Chem Lett (2014) 5, 346-351. PubMed Europe PubMed DOI S I
Masuyer,G., Akif,M., Czarny,B., Beau,F., Schwager,S.L., Sturrock,E.D., Isaac,R.E., Dive,V. and Acharya,K.R. Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme FEBS J (2014) 281, 943-956. PubMed Europe PubMed DOI S I
Yates,C.J., Masuyer,G., Schwager,S.L., Akif,M., Sturrock,E.D. and Acharya,K.R. Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE) J Biol Chem (2014) 289, 1798-1814. PubMed Europe PubMed DOI S

2013

Hocharoen,L., Joyner,J.C. and Cowan,J.A. N- versus C-domain selectivity of catalytic inactivation of human angiotensin converting enzyme by lisinopril-coupled transition metal chelates J Med Chem (2013) 56, 9826-9836. PubMed Europe PubMed DOI I

2012

Bersanetti,P.A., Sabatini,R.A., Matos,B.S., Douglas,R.G., Nchinda,A., Juliano,M.A., Pesquero,J.B., Sturrock,E.D. and Carmona,A.K. Characterization of angiotensin I-converting enzyme N-domain selectivity using positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides Biol Chem (2012) 393, 1547-1554. PubMed Europe PubMed DOI P
Masuyer,G., Schwager,S.L., Sturrock,E.D., Isaac,R.E. and Acharya,K.R. Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides Sci Rep (2012) 2, 717-717. PubMed Europe PubMed DOI PMC EPMC I
Ong,F.S., Lin,C.X., Campbell,D.J., Okwan-Duodu,D., Chen,X., Blackwell,W.L., Shah,K.H., Gonzalez-Villalobos,R.A., Shen,X.Z., Fuchs,S. and Bernstein,K.E. Increased angiotensin II-induced hypertension and inflammatory cytokines in mice lacking angiotensin-converting enzyme N domain activity Hypertension (2012) 59, 283-290. PubMed Europe PubMed DOI
Sharma,R.K., Douglas,R.G., Louw,S., Chibale,K. and Sturrock,E.D. New ketomethylene inhibitor analogues: synthesis and assessment of structural determinants for N-domain selective inhibition of angiotensin-converting enzyme Biol Chem (2012) 393, 485-493. PubMed Europe PubMed DOI I
Sturrock,E.D., Anthony,C.S. and Danilov,S.M. Peptidyl-dipeptidase A/angiotensin I-converting enzyme [ISSN:978-0-12-407744-7] (2012) 3, 480-494. DOI

2011

Akif,M., Schwager,S.L., Anthony,C.S., Czarny,B., Beau,F., Dive,V., Sturrock,E.D. and Acharya,K.R. Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide Biochem J (2011) 436, 53-59. PubMed Europe PubMed DOI S I
Bernstein,K.E., Shen,X.Z., Gonzalez-Villalobos,R.A., Billet,S., Okwan-Duodu,D., Ong,F.S. and Fuchs,S. Different in vivo functions of the two catalytic domains of angiotensin-converting enzyme (ACE) Curr Opin Pharmacol (2011) 11, 105-111. PubMed Europe PubMed DOI

2010

Anthony,C.S., Corradi,H.R., Schwager,S.L., Redelinghuys,P., Georgiadis,D., Dive,V., Acharya,K.R. and Sturrock,E.D. The N domain of human angiotensin-I-converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407 J Biol Chem (2010) 285, 35685-35693. PubMed Europe PubMed DOI S I
Gordon,K., Balyasnikova,I.V., Nesterovitch,A.B., Schwartz,D.E., Sturrock,E.D. and Danilov,S.M. Fine epitope mapping of monoclonal antibodies 9B9 and 3G8 to the N domain of angiotensin-converting enzyme (CD143) defines a region involved in regulating angiotensin-converting enzyme dimerization and shedding Tissue Antigens (2010) 75, 136-150. PubMed Europe PubMed DOI
Li,P., Xiao,H.D., Xu,J., Ong,F.S., Kwon,M., Roman,J., Gal,A., Bernstein,K.E. and Fuchs,S. Angiotensin-converting enzyme N-terminal inactivation alleviates bleomycin-induced lung injury Am J Pathol (2010) 177, 1113-1121. PubMed Europe PubMed DOI K I
Spyranti,Z., Galanis,A.S., Pairas,G., Spyroulias,G.A., Manessi-Zoupa,E. and Cordopatis,P. Synthetic peptides as structural maquettes of angiotensin-I converting enzyme catalytic sites Bioinorg Chem Appl (2010) , 820476-820476. PubMed Europe PubMed DOI PMC EPMC
Sun,X., Rentzsch,B., Gong,M., Eichhorst,J., Pankow,K., Papsdorf,G., Maul,B., Bader,M. and Siems,W.E. Signal transduction in CHO cells stably transfected with domain-selective forms of murine ACE Biol Chem (2010) 391, 235-244. PubMed Europe PubMed DOI
Watermeyer,J., Kroger,W.L., Sturrock,E.D. and Ehlers,M.R. Angiotensin-converting enzyme - new insights into structure, biological significance and prospects for domain-selective inhibitors Curr Enzyme Inhib (2010) 5, 134-147.

2009

Kroger,W.L., Douglas,R.G., O'Neill,H.G., Dive,V. and Sturrock,E.D. Investigating the domain specificity of phosphinic inhibitors RXPA380 and RXP407 in angiotensin-converting enzyme Biochemistry (2009) 48, 8405-8412. PubMed Europe PubMed DOI I
Zou,K., Maeda,T., Watanabe,A., Liu,J., Liu,S., Oba,R., Satoh,Y., Komano,H. and Michikawa,M. Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme J Biol Chem (2009) 284, 31914-31920. PubMed Europe PubMed DOI PMC EPMC

2008

Danilov,S.M., Balyasnikova,I.V., Albrecht,R.F. and Kost,O.A. Simultaneous determination of ACE activity with 2 substrates provides information on the status of somatic ACE and allows detection of inhibitors in human blood J Cardiovasc Pharmacol (2008) 52, 90-103. PubMed Europe PubMed DOI A
O'Neill,H.G., Redelinghuys,P., Schwager,S.L. and Sturrock,E.D. The role of glycosylation and domain interactions in the thermal stability of human angiotensin-converting enzyme Biol Chem (2008) 389, 1153-1161. PubMed Europe PubMed DOI
Rushworth,C.A., Guy,J.L. and Turner,A.J. Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis FEBS J (2008) 275, 6033-6042. PubMed Europe PubMed DOI I
Toropygin,I.Y., Kugaevskaya,E.V., Mirgorodskaya,O.A., Elisseeva,Y.E., Kozmin,Y.P., Popov,I.A., Nikolaev,E.N., Makarov,A.A. and Kozin,S.A. The N-domain of angiotensin-converting enzyme specifically hydrolyzes the Arg-5-His-6 bond of Alzheimer's Abeta-(1-16) peptide and its isoAsp-7 analogue with different efficiency as evidenced by quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry Rapid Commun Mass Spectrom (2008) 22, 231-239. PubMed Europe PubMed DOI
Watermeyer,J.M., Kroger,W.L., O'Neill,H.G., Sewell,B.T. and Sturrock,E.D. Probing the basis of domain-dependent inhibition using novel ketone inhibitors of angiotensin-converting enzyme Biochemistry (2008) 47, 5942-5950. PubMed Europe PubMed DOI I

2007

Balyasnikova,I.V., Skirgello,O.E., Binevski,P.V., Nesterovitch,A.B., Albrecht,R.F., Kost,O.A. and Danilov,S.M. Monoclonal antibodies 1G12 and 6A12 to the N-domain of human angiotensin-converting enzyme: fine epitope mapping and antibody-based detection of ACE inhibitors in human blood J Proteome Res (2007) 6, 1580-1594. PubMed Europe PubMed DOI
Danilov,S.M., Watermeyer,J.M., Balyasnikova,I.V., Gordon,K., Kugaevskaya,E.V., Elisseeva,Y.E., Albrecht,R.F. and Sturrock,E.D. Fine epitope mapping of monoclonal antibody 5F1 reveals anticatalytic activity toward the N domain of human angiotensin-converting enzyme Biochemistry (2007) 46, 9019-9031. PubMed Europe PubMed DOI
Vamvakas,S.S., Leondiadis,L., Pairas,G., Manessi-Zoupa,E., Spyroulias,G.A. and Cordopatis,P. Expression, purification, and physicochemical characterization of the N-terminal active site of human angiotensin-I converting enzyme J Pept Sci (2007) 13, 31-36. PubMed Europe PubMed DOI E

2006

[YEAR:19-12-2006]Bernstein,K.E. Views of the renin-angiotensin system: brilling, mimsy, and slithy tove Hypertension (19-12-2006) 47, 509-514. PubMed Europe PubMed DOI V
Carmona,A.K., Schwager,S.L., Juliano,M.A., Juliano,L. and Sturrock,E.D. A continuous fluorescence resonance energy transfer angiotensin I-converting enzyme assay Nat Protoc (2006) 1, 1971-1976. PubMed Europe PubMed DOI A
Corradi,H.R., Schwager,S.L., Nchinda,A.T., Sturrock,E.D. and Acharya,K.R. Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design J Mol Biol (2006) 357, 964-974. PubMed Europe PubMed DOI S T I
Kohlstedt,K., Gershome,C., Friedrich,M., Muller-Esterl,W., Alhenc-Gelas,F., Busse,R. and Fleming,I. Angiotensin-converting enzyme (ACE) dimerization is the initial step in the ACE inhibitor-induced ACE signaling cascade in endothelial cells Mol Pharmacol (2006) 69, 1725-1732. PubMed Europe PubMed DOI
[YEAR:13-3-2006]Kugaevskaya,E.V., Kolesanova,E.F., Kozin,S.A., Veselovsky,A.V., Dedinsky,I.R. and Elisseeva,Y.E. Epitope mapping of the domains of human angiotensin converting enzyme Biochim Biophys Acta (13-3-2006) 1760, 959-965. PubMed Europe PubMed DOI
[YEAR:18-4-2006]Skirgello,O.E., Balyasnikova,I.V., Binevski,P.V., Sun,Z.L., Baskin,I.I., Palyulin,V.A., Nesterovitch,A.B., Albrecht,R.F., Kost,O.A. and Danilov,S.M. Inhibitory antibodies to human angiotensin-converting enzyme: fine epitope mapping and mechanism of action Biochemistry (18-4-2006) 45, 4831-4847. PubMed Europe PubMed DOI

2005

Alves,M.F., Araujo,M.C., Juliano,M.A., Oliveira,E.M., Krieger,J.E., Casarini,D.E., Juliano,L. and Carmona,A.K. A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity Braz J Med Biol Res (2005) 38, 861-868. PubMed Europe PubMed DOI A
Balyasnikova,I.V., Woodman,Z.L., Albrecht,R.F., Natesh,R., Acharya,K.R., Sturrock,E.D. and Danilov,S.M. Localization of an N-domain region of angiotensin-converting enzyme involved in the regulation of ectodomain shedding using monoclonal antibodies J Proteome Res (2005) 4, 258-267. PubMed Europe PubMed DOI
Redelinghuys,P., Nchinda,A.T. and Sturrock,E.D. Development of domain-selective angiotensin I-converting enzyme inhibitors Ann N Y Acad Sci (2005) 1056, 160-175. PubMed Europe PubMed DOI V
[YEAR:1-8-2005]Woodman,Z.L., Schwager,S.L., Redelinghuys,P., Carmona,A.K., Ehlers,M.R. and Sturrock,E.D. The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity Biochem J (1-8-2005) 389, 739-744. PubMed Europe PubMed DOI PMC EPMC

2004

Corvol,P., Eyries,M. and Soubrier,F. Peptidyl-dipeptidase A/angiotensin I-converting enzyme [ISSN:0-12-079610-4] (2004) 2, 332-346. V
[YEAR:16-4-2004]Fuchs,S., Xiao,H.D., Cole,J.M., Adams,J.W., Frenzel,K., Michaud,A., Zhao,H., Keshelava,G., Capecchi,M.R., Corvol,P. and Bernstein,K.E. Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice J Biol Chem (16-4-2004) 279, 15946-15953. PubMed Europe PubMed DOI
Inguimbert,N., Poras,H., Dhotel,H., Beslot,F., Scalbert,E., Bennejean,C., Renard,P., Fournie-Zaluski,M.C. and Roques,B.P. In vivo properties of thiol inhibitors of the three vasopeptidases NEP, ACE and ECE are improved by introduction of a 7-azatryptophan in P2' position J Pept Res (2004) 63, 99-107. PubMed Europe PubMed DOI I
Spyroulias,G.A., Galanis,A.S., Pairas,G., Manessi-Zoupa,E. and Cordopatis,P. Structural features of angiotensin-I converting enzyme catalytic sites: conformational studies in solution, homology models and comparison with other zinc metallopeptidases Curr Top Med Chem (2004) 4, 403-429. PubMed Europe PubMed DOI
Sturrock,E.D., Natesh,R., van Rooyen,J.M. and Acharya,K.R. Structure of angiotensin I-converting enzyme Cell Mol Life Sci (2004) 61, 2677-2686. PubMed Europe PubMed DOI V S I

2003

[YEAR:28-8-2003]Binevski,P.V., Sizova,E.A., Pozdnev,V.F. and Kost,O.A. Evidence for the negative cooperativity of the two active sites within bovine somatic angiotensin-converting enzyme FEBS Lett (28-8-2003) 550, 84-88. PubMed Europe PubMed DOI I
[YEAR:22-8-2003]Fernandez,J.H., Hayashi,M.A., Camargo,A.C. and Neshich,G. Structural basis of the lisinopril-binding specificity in N- and C-domains of human somatic ACE Biochem Biophys Res Commun (22-8-2003) 308, 219-226. PubMed Europe PubMed DOI
Marques,G.D., Quinto,B.M., Plavinik,F.L., Krieger,J.E., Marson,O. and Casarini,D.E. N-domain angiotensin I-converting enzyme with 80 kDa as a possible genetic marker of hypertension Hypertension (2003) 42, 693-701. PubMed Europe PubMed DOI
Tzakos,A.G., Galanis,A.S., Spyroulias,G.A., Cordopatis,P., Manessi-Zoupa,E. and Gerothanassis,I.P. Structure-function discrimination of the N- and C- catalytic domains of human angiotensin-converting enzyme: implications for Cl- activation and peptide hydrolysis mechanisms Protein Eng (2003) 16, 993-1003. PubMed Europe PubMed DOI

2002

Voronov,S., Zueva,N., Orlov,V., Arutyunyan,A. and Kost,O. Temperature-induced selective death of the C-domain within angiotensin-converting enzyme molecule FEBS Lett (2002) 522, 77-82. PubMed Europe PubMed DOI

2001

Junot,C., Gonzales,M.F., Ezan,E., Cotton,J., Vazeux,G., Michaud,A., Azizi,M., Vassiliou,S., Yiotakis,A., Corvol,P. and Dive,V. RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis J Pharmacol Exp Ther (2001) 297, 606-611. PubMed Europe PubMed I
Menard,J. and Patchett,A.A. Angiotensin-converting enzyme inhibitors Adv Protein Chem (2001) 56, 13-75. PubMed Europe PubMed DOI V I
[YEAR:1-4-2001]Vazeux,G., Cotton,J., Cuniasse,P. and Dive,V. Potency and selectivity of RXP407 on human, rat, and mouse angiotensin-converting enzyme Biochem Pharmacol (1-4-2001) 61, 835-841. PubMed Europe PubMed DOI I

2000

[YEAR:25-7-2000]Araujo,M.C., Melo,R.L., Cesari,M.H., Juliano,M.A., Juliano,L. and Carmona,A.K. Peptidase specificity characterization of C- and N-terminal catalytic sites of angiotensin I-converting enzyme Biochemistry (25-7-2000) 39, 8519-8525. PubMed Europe PubMed DOI
Azizi,M., Massien,C., Michaud,A. and Corvol,P. In vitro and in vivo inhibition of the 2 active sites of ACE by omapatrilat, a vasopeptidase inhibitor Hypertension (2000) 35, 1226-1231. PubMed Europe PubMed I
Binevski,P.V., Nikolskaya,I.I., Pozdnev,V.F. and Kost,O.A. Isolation and characterization of the N-domain of bovine angiotensin-converting enzyme Biochemistry (Mosc) (2000) 65, 651-658. PubMed Europe PubMed
[YEAR:10-4-2000]Cheviron,N., Rousseau-Plasse,A., Lenfant,M., Adeline,M.T., Potier,P. and Thierry,J. Coumarin-Ser-Asp-Lys-Pro-OH, a fluorescent substrate for determination of angiotensin-converting enzyme activity via high-performance liquid chromatography Anal Biochem (10-4-2000) 280, 58-64. PubMed Europe PubMed DOI A
[YEAR:1-8-2000]Coates,D., Isaac,R.E., Cotton,J., Siviter,R., Williams,T.A., Shirras,A., Corvol,P. and Dive,V. Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme Biochemistry (1-8-2000) 39, 8963-8969. PubMed Europe PubMed DOI I
[YEAR:25-8-2000]Kessler,S.P., Rowe,T.M., Gomos,J.B., Kessler,P.M. and Sen,G.C. Physiological non-equivalence of the two isoforms of angiotensin-converting enzyme J Biol Chem (25-8-2000) 275, 26259-26264. PubMed Europe PubMed DOI
Ortiz-Salmeron,E., Baron,C. and Garcia-Fuentes,L. Separation and purification of N-domain of bovine lung angiotensin I-converting enzyme by size exclusion chromatography J Liq Chromatogr Relat Technol (2000) 23, 1499-1510. DOI

1999

Araujo,M.C., Melo,R.I., Del Nery,E., Alves,M.F., Juliano,M.A., Casarini,D.E., Juliano,L. and Carmona,A.K. Internally quenched fluorogenic substrates for angiotensin I-converting enzyme J Hypertens (1999) 17, 665-672. PubMed Europe PubMed DOI A
[YEAR:13-4-1999]Dive,V., Cotton,J., Yiotakis,A., Michaud,A., Vassiliou,S., Jiracek,J., Vazeux,G., Chauvet,M.T., Cuniasse,P. and Corvol,P. RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites Proc Natl Acad Sci U S A (13-4-1999) 96, 4330-4335. PubMed Europe PubMed DOI PMC EPMC I
Junot,C., Menard,J., Gonzales,M.F., Michaud,A., Corvol,P. and Ezan,E. In vivo assessment of captopril selectivity of angiotensin I-converting enzyme inhibition: differential inhibition of acetyl-Ser-Asp-Lys-Pro and angiotensin I hydrolysis J Pharmacol Exp Ther (1999) 289, 1257-1261. PubMed Europe PubMed I
[YEAR:15-3-1999]Michaud,A., Chauvet,M.T. and Corvol,P. N-domain selectivity of angiotensin I-converting enzyme as assessed by structure-function studies of its highly selective substrate, N-acetyl-seryl-aspartyl-lysyl-proline Biochem Pharmacol (15-3-1999) 57, 611-618. PubMed Europe PubMed DOI

1998

Deddish,P.A., Marcic,B., Jackman,H.L., Wang,H.Z., Skidgel,R.A. and Erdos,E.G. N-domain-specific substrate and C-domain inhibitors of angiotensin-converting enzyme: angiotensin-(1-7) and keto-ACE Hypertension (1998) 31, 912-917. PubMed Europe PubMed I

1997

Deddish,P.A., Jackman,H.L., Skidgel,R.A. and Erdos,E.G. Differences in the hydrolysis of enkephalin congeners by the two domains of angiotensin converting enzyme Biochem Pharmacol (1997) 53, 1459-1463. PubMed Europe PubMed DOI
Esther,C.R., Marino,E.M., Howard,T.E., Machaud,A., Corvol,P., Capecchi,M.R. and Bernstein,K.E. The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice J Clin Invest (1997) 99, 2375-2385. PubMed Europe PubMed DOI PMC EPMC K
Hayakari,M., Satoh,K., Ookawa,K., Kano,H., Murakami,S., Ikeda,N. and Tsuchida,S. Kinetic evaluation of beta-neoendorphin hydrolysis by the somatic and testicular isozymes of human angiotensin-converting enzyme Biochim Biophys Acta (1997) 1339, 31-38. PubMed Europe PubMed DOI
Michaud,A., Williams,T.A., Chauvet,M.T. and Corvol,P. Substrate dependence of angiotensin I-converting enzyme inhibition: captopril displays a partial selectivity for inhibition of N-acetyl-seryl-aspartyl-lysyl-proline hydrolysis compared with that of angiotensin I Mol Pharmacol (1997) 51, 1070-1076. PubMed Europe PubMed I
Sturrock,E.D., Danilov,S.M. and Riordan,J.F. Limited proteolysis of human kidney angiotensin-converting enzyme and generation of catalytically active N- and C-terminal domains Biochem Biophys Res Commun (1997) 236, 16-19. PubMed Europe PubMed DOI

1996

Azizi,M., Rousseau,A., Ezan,E., Guyene,T.T., Michelet,S., Grognet,J.M., Lenfant,M., Corvol,P. and Menard,J. Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline J Clin Invest (1996) 97, 839-844. PubMed Europe PubMed DOI PMC EPMC
Bevilacqua,M., Vago,T., Rogolino,A., Conci,F., Santoli,E. and Norbiato,G. Affinity of angiotensin I-converting enzyme (ACE) inhibitors for N- and C-binding sites of human ACE is different in heart, lung, arteries, and veins J Cardiovasc Pharmacol (1996) 28, 494-499. PubMed Europe PubMed DOI I
Deddish,P.A., Wang,L.X., Jackman,H.L., Michel,B., Wang,J., Skidgel,R.A. and Erdos,E.G. Single-domain angiotensin I converting enzyme (kininase II): characterization and properties J Pharmacol Exp Ther (1996) 279, 1582-1589. PubMed Europe PubMed I
Esther,C.R., Jr., Howard,T.E., Marino,E.M., Goddard,J.M., Capecchi,M.R. and Bernstein,K.E. Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility Lab Invest (1996) 74, 953-965. PubMed Europe PubMed K
Williams,T.A., Danilov,S., Alhenc-Gelas,F. and Soubrier,F. A study of chimeras constructed with the two domains of angiotensin I-converting enzyme Biochem Pharmacol (1996) 51, 11-14. PubMed Europe PubMed DOI

1995

Corvol,P., Michaud,A., Soubrier,F. and Williams,T.A. Recent advances in knowledge of the structure and function of the angiotensin I converting enzyme J Hypertens Suppl (1995) 13, S3-S10. PubMed Europe PubMed
Corvol,P., Williams,T.A. and Soubrier,F. Peptidyl dipeptidase A: angiotensin I-converting enzyme Methods Enzymol (1995) 248, 283-305. PubMed Europe PubMed DOI V
Jaspard,E. and Alhenc-Gelas,F. Catalytic properties of the two active sites of angiotensin I-converting enzyme on the cell surface Biochem Biophys Res Commun (1995) 211, 528-534. PubMed Europe PubMed DOI
Rousseau,A., Michaud,A., Chauvet,M.T., Lenfant,M. and Corvol,P. The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme J Biol Chem (1995) 270, 3656-3661. PubMed Europe PubMed DOI

1994

Deddish,P.A., Wang,J., Michel,B., Morris,P.W., Davidson,N.O., Skidgel,R.A. and Erdos,E.G. Naturally occurring active N-domain of human angiotensin I-converting enzyme Proc Natl Acad Sci U S A (1994) 91, 7807-7811. PubMed Europe PubMed DOI PMC EPMC
[YEAR:14-1-1994]Koike,G., Krieger,J.E., Jacob,H.J., Mukoyama,M., Pratt,R.E. and Dzau,V.J. Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme Biochem Biophys Res Commun (14-1-1994) 198, 380-386. PubMed Europe PubMed DOI
Williams,T.A., Corvol,P. and Soubrier,F. Identification of two active site residues in human angiotensin I-converting enzyme J Biol Chem (1994) 269, 29430-29434. PubMed Europe PubMed

1993

[YEAR:5-5-1993]Jaspard,E., Wei,L. and Alhenc-Gelas,F. Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides J Biol Chem (5-5-1993) 268, 9496-9503. PubMed Europe PubMed

1992

Perich,R.B., Jackson,B., Rogerson,F., Mendelsohn,F.A., Paxton,D. and Johnston,C.I. Two binding sites on angiotensin-converting enzyme: evidence from radioligand binding studies Mol Pharmacol (1992) 42, 286-293. PubMed Europe PubMed I
[YEAR:25-2-1992]Thekkumkara,T.J., Livingston,W., III, Kumar,R.S. and Sen,G.C. Use of alternative polyadenylation sites for tissue-specific transcription of two angiotensin-converting enzyme mRNAs Nucleic Acids Res (25-2-1992) 20, 683-687. PubMed Europe PubMed PMC EPMC
[YEAR:5-7-1992]Wei,L., Clauser,E., Alhenc-Gelas,F. and Corvol,P. The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors J Biol Chem (5-7-1992) 267, 13398-13405. PubMed Europe PubMed I