Structure for peptidase C01.060: cathepsin B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1CSB	Homo sapiens	2.10 Å	mature
Catalytic residues are shown in ball-and-stick representation: Cys108 in yellow, His278 in purple and Asn298 in pink. His189 on the occluding loop is shown in purple in ball-and-stick representation. CA030 is shown in grey in ball-and-stick representation.

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1MIR	Rattus norvegicus	2.80 Å	precursor
Catalytic residues are shown in ball-and-stick representation: Cys108 in yellow, His278 in purple and Asn298 in pink. His189 on the occluding loop is shown in purple in ball-and-stick representation. The propeptide is shown in grey.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Bos taurus
complex with E64c	2.29 Å	1ITO	1ITO	1ITO	1ITO	1ITO	1ITO	Yamamoto et al., 2002
complex with CA074 inhibitor	2.18 Å	1QDQ	1QDQ	1QDQ	1QDQ	1QDQ	1QDQ	Yamamoto et al., 2000
complex with NS-134, a two headed epoxysuccinyl inhibitor	2.20 Å	1SP4	1SP4	1SP4	1SP4	1SP4	1SP4	Stern et al., 2004
mature peptidase	2.30 Å	2DC6	2DC6	2DC6	2DC6	2DC6	2DC6
mature peptidase	1.94 Å	2DC7	2DC7	2DC7	2DC7	2DC7	2DC7
mature peptidase	1.94 Å	2DC8	2DC8	2DC8	2DC8	2DC8	2DC8
mature peptidase	1.94 Å	2DC9	2DC9	2DC9	2DC9	2DC9	2DC9
mature peptidase	2.11 Å	2DCA	2DCA	2DCA	2DCA	2DCA	2DCA
mature peptidase	1.94 Å	2DCB	2DCB	2DCB	2DCB	2DCB	2DCB
mature peptidase	1.93 Å	2DCC	2DCC	2DCC	2DCC	2DCC	2DCC
mature peptidase	2.50 Å	2DCD	2DCD	2DCD	2DCD	2DCD	2DCD
Homo sapiens
mature peptidase	2.10 Å	1CSB	1CSB	1CSB	1CSB	1CSB	1CSB	Turk et al., 1995
mature peptidase	2.00 Å	1CSB	1CSB	1CSB	1CSB	1CSB	1CSB	Turk et al., 1995
complex with a dipeptidyl nitrile inhibitor	1.90 Å	1GMY	1GMY	1GMY	1GMY	1GMY	1GMY	Greenspan et al., 2001
mature peptidase	1.90 Å	1GMY	1GMY	1GMY	1GMY	1GMY	1GMY	Greenspan et al., 2001
mature peptidase	2.10 Å	1HUC	1HUC	1HUC	1HUC	1HUC	1HUC	Musil et al., 1991
mature peptidase	2.10 Å	1HUC	1HUC	1HUC	1HUC	1HUC	1HUC	Musil et al., 1991
recombinant precursor	3.20 Å	1PBH	1PBH	1PBH	1PBH	1PBH	1PBH	Turk et al., 1996
recombinant precursor	3.20 Å	1PBH	1PBH	1PBH	1PBH	1PBH	1PBH	Turk et al., 1996
tetragonal form	2.15 Å	2IPP	2IPP	2IPP	2IPP	2IPP	2IPP
recombinant precursor	3.30 Å	2PBH	2PBH	2PBH	2PBH	2PBH	2PBH	Turk et al., 1996
recombinant precursor	3.30 Å	2PBH	2PBH	2PBH	2PBH	2PBH	2PBH	Turk et al., 1996
mature peptidase	2.11 Å	3AI8	3AI8	3AI8	3AI8	3AI8	3AI8	Mirkovic et al., 2011
complex with chagasin	1.80 Å	3CBJ	3CBJ	3CBJ	3CBJ	3CBJ	3CBJ
complex with chagasin	2.67 Å	3CBK	3CBK	3CBK	3CBK	3CBK	3CBK
mature peptidase	2.61 Å	3K9M	3K9M	3K9M	3K9M	3K9M	3K9M	Renko et al., 2010
recombinant precursor	2.50 Å	3PBH	3PBH	3PBH	3PBH	3PBH	3PBH	Turk et al., 1996
recombinant precursor	2.50 Å	3PBH	3PBH	3PBH	3PBH	3PBH	3PBH	Turk et al., 1996
complex with darpin 81	1.81 Å	5MBL	5MBL	5MBL	5MBL	5MBL	5MBL
complex with covalently linked compound 28	1.60 Å	6AY2	6AY2	6AY2	6AY2	6AY2	6AY2
Rattus norvegicus
Ser115Ala mutant	2.20 Å	1CPJ	1CPJ	1CPJ	1CPJ	1CPJ	1CPJ	Jia et al., 1995
mature peptidase	2.10 Å	1CTE	1CTE	1CTE	1CTE	1CTE	1CTE	Jia et al., 1995
precursor	2.80 Å	1MIR	1MIR	1MIR	1MIR	1MIR	1MIR	Cygler et al., 1996
Ser115Ala mutant; complex with Z-Arg-Ser(OBzl) chloromethylketone	1.90 Å	1THE	1THE	1THE	1THE	1THE	1THE	Jia et al., 1995