Literature for peptidase C01.060: cathepsin B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Bird,L.E., Xu,B., Hobbs,A.D., Ziegler,A.R., Scott,N.E., Newton,P., Thomas,D.R., Edgington-Mitchell,L.E. and Newton,H.J.
Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success
Nat Commun16, 3844-3844. PubMed Europe PubMed DOI
Goto,A., Omori,K., Yamaguchi-Tomikawa,T., Kobayashi,H., Shinoda-Ito,Y., Hirai,K., Ikeda,A. and Takashiba,S.
Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways
Front Dent Med6, 1547222-1547222. PubMed Europe PubMed DOI
Habarakadage,B., Rajendran,S., Ren,Z., Anderson,M.J., Koehne,J., Gorla,L., Morita,S., Wu,S., Hua,D.H. and Li,J.
Mitigating dithiothreitol interference to gold/thiol interface in electrochemical detection of cathepsin B activity toward multiplex protease analysis
Biosens Bioelectron273, 117193-117193. PubMed Europe PubMed DOI
Hossain,S., Bin Manjur,O.H., Shimu,M.S.S., Sultana,T., Naim,M.R., Siddique,S., Al Mamun,A., Rahman,M.M., Saleh,M.A., Hasan,M.R. and Rahman,T.
In silico evaluation of missense SNPs in cancer-associated Cystatin A protein and their potential to disrupt Cathepsin B interaction
Heliyon11, e42478-e42478. PubMed Europe PubMed DOI
Lin,H., Nie,L., Wu,D., Zhang,D., Peng,R., Tao,S., Ye,Z., Zhu,S., Ye,M. and Xiao,J.
Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia
Commun Biol8, 845-845. PubMed Europe PubMed DOI
Liu,H., Xu,L., Wang,T., Liu,Y., Pan,J., Xiong,W., Zheng,F., Wang,Y. and Sun,S.
Cathepsin B-induced cascade DNA-AuNP nanomachine for activated tumor theranostics
Talanta293, 128103-128103. PubMed Europe PubMed DOI
Modenbach,J.M., Moller,C., Asgarbeik,S., Geist,N., Rimkus,N., Dorr,M., Wolfgramm,H., Steil,L., Susemihl,A., Graf,L., Schmoker,O., Bottcher,D., Hammer,E., Glaubitz,J., Lammers,M., Delcea,M., Volker,U., Aghdassi,A.A., Lerch,M.M., Weiss,F.U., Bornscheuer,U.T. and Sendler,M.
Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis
Nat Commun16, 1702-1702. PubMed Europe PubMed DOI
Ntemafack,A., Dzelamonyuy,A., Nchinda,G. and Bopda Waffo,A.
Mapping Immunological, Host Receptor Binding Determinants, and Cathepsin Cleavage Site of EBOV Glycoprotein Utilizing the Qubevirus Platform
ACS Omega10, 14283-14295. PubMed Europe PubMed DOI
Pinto,A., Haytural,H., Loss,C., Alvarez,C., Ertas,A., Curtis,O., Williams,A.R., Murphy,G., Salleng,K., Gografe,S., Altintas,A., Kafri,T., Barres,R., Deshmukh,A.S. and van Praag,H.
Muscle Cathepsin B treatment improves behavioral and neurogenic deficits in a mouse model of Alzheimer's Disease
bioRxiv PubMed Europe PubMed DOI
Podvin,S., Florio,J., Spencer,B., Mante,M., Guzman,E., Arias,C., Mosier,C., Phan,V.V., Yoon,M.C., Almaliti,J., O'Donoghue,A.J., Gerwick,W.H., Rissman,R.A. and Hook,V.
Activation of Cytosolic Cathepsin B Activity in the Brain by Traumatic Brain Injury and Inhibition by the Neutral pH Selective Inhibitor Probe Z-Arg-Lys-AOMK
ACS Chem Neurosci16, 1297-1308. PubMed Europe PubMed DOI
Tang,C., Wang,J., Ge,M., Fu,L., Huang,J., Yadav,H., Shi,J., Feng,S. and Wu,F.
DSS-induced colitis exacerbates Alzheimer's pathology via neutrophil elastase and cathepsin B activation
Int Immunopharmacol155, 114666-114666. PubMed Europe PubMed DOI
Wu,Y., Cleverley,K. and Wiseman,F.K.
Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy 21 human cellular and mouse models
PLoS ONE20, e0316822-e0316822. PubMed Europe PubMed DOI
Xu,M., Zhang,W., Xiong,Y., Fu,H., Qiao,H., Jiang,S. and Jin,S.
Identification of Potential Roles of Cathepsin B-like in the Response to Alkali Treatment in Macrobrachium nipponense
Int J Mol Sci26, PubMed Europe PubMed DOI
Yang,X., Cea-Medina,P., Gopalswamy,M., Vaidya,A., Schavier,S., Oltzen,S., Mossner,S., Huang,A., Qi,J., Holken,J.M., Teusch,N., Floss,D.M., Uhrberg,M., Gohlke,H. and Scheu,S.
The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B
Protein Sci34, e70173-e70173. PubMed Europe PubMed DOI I
Yu,Q., Xu,D., Chen,S., Yu,Y., Yu,H., Li,Y., Sun,W. and Yin,S.
Cathepsin B Activatable Fluorescent Probe for Antitumor Efficiency Feedback: Attempt To Detect Certain Apoptotic Cells
Anal Chem PubMed Europe PubMed DOI
Zhang,J.S., Meng,J.Y., Yang,L. and Zhang,C.Y.
Identification and expression analysis of cathepsin B genes in Myzus persicae (Hemiptera: Aphididae) and their response to environmental stresses
Bull Entomol Res1-11. PubMed Europe PubMed DOI
Zhao,Q., Li,H., Liu,D., Zhou,B., Gong,C., Chen,L. and Liao,F.
The SGLT2 inhibitor dapagliflozin suppresses endothelial cell pyroptosis mediated by the NF-kappaB/NLRP3 pathway through downregulation of CTSB
Biochem Pharmacol236, 116857-116857. PubMed Europe PubMed DOI
Zhao,Y., Zhuang,Y., Shi,J., Fan,H., Lv,Q. and Guo,X.
Cathepsin B induces kidney diseases through different types of programmed cell death
Front Immunol16, 1535313-1535313. PubMed Europe PubMed DOI V

2024

Bernardim,B., Conde,J., Hakala,T., Becher,J.B., Canzano,M., Vasco,A.V., Knowles,T.P.J., Cameron,J. and Bernardes,G.J.L.
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin-Drug Conjugates
Bioconjug Chem35, 132-139. PubMed Europe PubMed DOI
Cai,Z., Xu,S. and Liu,C.
Cathepsin B in cardiovascular disease: Underlying mechanisms and therapeutic strategies
J Cell Mol Med28, e70064-e70064. PubMed Europe PubMed DOI V
Cao,F., Tang,C., Chen,X., Tu,Z., Jin,Y., Turk,O.M., Nishimura,R.N., Ebens,A., Dubljevic,V., Campbell,J.A., Zhou,J. and Hansen,J.E.
Cathepsin B Nuclear Flux in a DNA-Guided "Antinuclear Missile" Cancer Therapy
ACS Cent Sci10, 1562-1572. PubMed Europe PubMed DOI
Dai,Q., Xie,L., Ren,E. and Liu,G.
Cathepsin B Responsive Peptide-Purpurin Conjugates Assembly-Initiated in Situ Self-Aggregation for Cancer Sonotheranostics
Nano Lett24, 950-957. PubMed Europe PubMed DOI
Deng,Y., Yan,K., Xu,L., Liu,X., Zhao,F., Wang,S., Zhang,F., Liang,G. and Wang,R.
"Turn-on" NIR-II fluorescence of a dually quenched probe for sensitive imaging of cathepsin B in vivo
Chem Commun (Camb) PubMed Europe PubMed DOI
Dietze,K.A., Nguyen,K., Pathni,A., Fazekas,F., Baker,J.M., Gebru,E., Wang,A., Sun,W., Rosati,E., Lum,D., Rapoport,A.P., Fan,X., Atanackovic,D., Upadhayaya,A. and Luetkens,T.
Cathepsin B causes trogocytosis-mediated CAR T cell dysfunction
bioRxiv PubMed Europe PubMed DOI
Geri,A., Massai,L., Novinec,M., Turel,I. and Messori,L.
Reactions of Medicinal Gold Compounds with Cathepsin B Explored through Electrospray Mass Spectrometry Measurements
Chempluschem89, e202300321-e202300321. PubMed Europe PubMed DOI
Jangra,S., Raghav,N., Wadhwa,D., Kumar,A., Bhattacharyya,S., Kumar,V. and Sheokand,J.
Biological evaluation of trans-2,3-dihydrofuro[3,2-c]coumarins as potential cathepsin inhibitors and anticancer agents
J Biomater Sci Polym Ed1-19. PubMed Europe PubMed DOI I
Jiang,M., Ge,Z., Yin,S., Liu,Y., Gao,H., Lu,L., Wang,H., Li,C., Ni,J., Pan,Y. and Lin,L.
Cathepsin B Modulates Alzheimer's Disease Pathology Through SAPK/JNK Signals Following Administration of Porphyromonas gingivalis-Derived Outer Membrane Vesicles
J Clin Periodontol PubMed Europe PubMed DOI
Jinda,H., Nakashima,K., Watanabe,H. and Ono,M.
Synthesis and Evaluation of a Cathepsin B-Recognizing Trifunctional Chelating Agent to Improve Tumor Retention of Radioimmunoconjugates
J Labelled Comp Radiopharm67, 295-304. PubMed Europe PubMed DOI
Jones-Tabah,J., He,K., Karpilovsky,N., Senkevich,K., Deyab,G., Pietrantonio,I., Goiran,T., Cousineau,Y., Nikanorova,D., Goldsmith,T., Del Cid Pellitero,E., Chen,C.X., Luo,W., You,Z., Abdian,N., Ahmad,J., Ruskey,J.A., Asayesh,F., Spiegelman,D., Fahn,S., Waters,C., Monchi,O., Dauvilliers,Y., Dupre,N., Miliukhina,I., Timofeeva,A., Emelyanov,A., Pchelina,S., Greenbaum,L., Hassin-Baer,S., Alcalay,R.N., Milnerwood,A., Durcan,T.M., Gan-Or,Z. and Fon,E.A.
Correction: The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
Mol Neurodegener19, 94-94. PubMed Europe PubMed DOI
Jones-Tabah,J., He,K., Karpilovsky,N., Senkevich,K., Deyab,G., Pietrantonio,I., Goiran,T., Cousineau,Y., Nikanorova,D., Goldsmith,T., Del Cid Pellitero,E., Chen,C.X., Luo,W., You,Z., Abdian,N., Ahmad,J., Ruskey,J.A., Asayesh,F., Spiegelman,D., Fahn,S., Waters,C., Monchi,O., Dauvilliers,Y., Dupre,N., Miliukhina,I., Timofeeva,A., Emelyanov,A., Pchelina,S., Greenbaum,L., Hassin-Baer,S., Alcalay,R.N., Milnerwood,A., Durcan,T.M., Gan-Or,Z. and Fon,E.A.
The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
Mol Neurodegener19, 88-88. PubMed Europe PubMed DOI
Kumar,A., Rani,M., Giovannuzzi,S., Raghav,N., Supuran,C.T. and Sharma,P.K.
Novel thiazolotriazole and triazolothiadiazine scaffolds as selective tumor associated carbonic anhydrase inhibitors endowed with cathepsin B inhibition
Arch Pharm (Weinheim)e2400366-e2400366. PubMed Europe PubMed DOI I
Li,H., Li,Y., Li,K., Wang,Q., Yang,J., Qiu,L. and Lin,J.
Positron Emission Tomography Imaging of Cathepsin B in Tumors with Activable Small Molecule Tracers
J Med Chem PubMed Europe PubMed DOI
Li,H., Liang,B., Gao,X., Peng,Y., Liu,Q., Qiu,L. and Lin,J.
Cathepsin B-Activated PET Tracer for In Vivo Tumor Imaging
Mol Pharm21, 1382-1389. PubMed Europe PubMed DOI
Li,M.Y., Wu,Y., Tang,H.L., Wang,Y., Li,B., He,Y.Y., Yan,G.J. and Yang,Z.M.
Embryo-Derived Cathepsin B Promotes Implantation and Decidualization by Activating Pyroptosis
Adv Sci (Weinh)e2402299-e2402299. PubMed Europe PubMed DOI
Liu,F., Zhou,T., Zhang,S., Li,Y., Chen,Y., Miao,Z., Wang,X., Yang,G., Li,Q., Zhang,L. and Liu,Y.
Cathepsin B: The dawn of tumor therapy
Eur J Med Chem269, 116329-116329. PubMed Europe PubMed DOI
Moller,C., Rimkus,N., Skala,F.F.O., Merouze,M., Bottcher,D., Dorr,M. and Bornscheuer,U.T.
Improved recombinant expression of soluble cathepsin B and L in Escherichia coli
Appl Microbiol Biotechnol108, 536-536. PubMed Europe PubMed DOI
Monika,M., Chander,C., Kaur,P., Raghav,N., Sharma,P.K. and Ram,S.
Synthesis, Biological Evaluation, and Computational Studies of Schiff's Base Derivatives of 4-(4-Amino-5-mercapto-4H-1,2,4-triazol-3-yl)benzenesulfonamide as Cathepsin B Inhibitors
Chem Biodiverse202402575-e202402575. PubMed Europe PubMed DOI
Nandhini,M., Pitchumani Violet Mary,C., Gopinath,S. and Vijayakumar,S.
Structure based interaction and molecular dynamics studies of cysteine protease Cathepsin B against curcumin and resveratrol
J Biomol Struct Dyn1-11. PubMed Europe PubMed DOI I
Norton,E.S., Whaley,L.A., Jones,V.K., Brooks,M.M., Russo,M.N., Morderer,D., Jessen,E., Schiapparelli,P., Ramos-Fresnedo,A., Zarco,N., Carrano,A., Rossoll,W., Asmann,Y.W., Lam,T.T., Chaichana,K.L., Anastasiadis,P.Z., Quinones-Hinojosa,A. and Guerrero-Cazares,H.
Cell-specific cross-talk proteomics reveals cathepsin B signaling as a driver of glioblastoma malignancy near the subventricular zone
Sci Adv10, eadn1607-eadn1607. PubMed Europe PubMed DOI K
Sagar,S., Gadkari,P., Hiwale,K.M., Jagtap,M.M. and Naseri,S.
Role of Cathepsin B Expression in Oral Squamous Cell Carcinoma: A Comprehensive Review
Cureus16, e54267-e54267. PubMed Europe PubMed DOI V
Siddiqui,A.A., Merquiol,E., Bruck-Haimson,R., Hirbawi,J., Boocholez,H., Cohen,I., Yan,Y., Dong,M.Q., Blum,G. and Cohen,E.
Cathepsin B promotes Abeta proteotoxicity by modulating aging regulating mechanisms
Nat Commun15, 8564-8564. PubMed Europe PubMed DOI K
Siwach,K., Arya,P., Vats,L., Sharma,V., Giovannuzzi,S., Raghav,N., Supuran,C.T. and Sharma,P.K.
Benzenesulfonamides functionalized with triazolyl-linked pyrazoles possess dual cathepsin B and carbonic anhydrase inhibitory action
Arch Pharm (Weinheim)e2400114-e2400114. PubMed Europe PubMed DOI I
Siwach,K., Rani,M., Vats,L., Giovannuzzi,S., Paul,A.K., Brahma,M., Kumari,N., Maruthi,M., Raghav,N., Supuran,C.T. and Sharma,P.K.
1,2,3-Triazole-based esters and carboxylic acids as nonclassical carbonic anhydrase inhibitors capable of cathepsin B inhibition
Arch Pharm (Weinheim)357, e2300372-e2300372. PubMed Europe PubMed DOI I
Stuart,S., Tarade,D. and Ohh,M.
Cathepsins L and B target HIF1alpha for oxygen-independent proteolytic cleavage
Sci Rep14, 14799-14799. PubMed Europe PubMed DOI
Vashisth,C., Kaushik,T., Vashisth,N. and Raghav,N.
Cinnamaldehyde hydrazone derivatives as potential cathepsin B inhibitors: parallel in-vitro investigation in liver and cerebrospinal fluid
Int J Biol Macromol272, 132684-132684. PubMed Europe PubMed DOI I
Vashisth,C., Verma,N.K., Afshari,M., Bendi,A. and Raghav,N.
In silico and in vitro validation of cinnamaldehyde as a potential cathepsin B inhibitor
Chem Biodiverse202401985-e202401985. PubMed Europe PubMed DOI I
Wang,D., Wang,T., Kim,D., Tan,S., Liu,S., Wan,J. and Deng,Q.
MicroRNA-375 modulates neutrophil chemotaxis via targeting Cathepsin B in zebrafish
Fish Shellfish Immunol154, 109933-109933. PubMed Europe PubMed DOI K
Yadav,S., Vashisth,C., Chaudhri,V., Singh,K., Raghav,N. and Pundeer,R.
Development of potential cathepsin B inhibitors: Synthesis of new bithiazole derivatives, in vitro studies supported with theoretical docking studies
Int J Biol Macromol281, 136290-136290. PubMed Europe PubMed DOI I

2023

Chou,M.Y., Liu,D., An,J., Xu,Y. and Cyster,J.G.
B cell peripheral tolerance is promoted by cathepsin B protease
Proc Natl Acad Sci U S A120, e2300099120-e2300099120. PubMed Europe PubMed DOI
Egorova,V.S., Kolesova,E.P., Lopus,M., Yan,N., Parodi,A. and Zamyatnin,A.A., Jr.
Smart Delivery Systems Responsive to Cathepsin B Activity for Cancer Treatment
Pharmaceutics15, PubMed Europe PubMed DOI V
Hirose,H., Nakata,E., Zhang,Z., Shibano,Y., Maekawa,M., Morii,T. and Futaki,S.
Macropinoscope: Real-Time Simultaneous Tracking of pH and Cathepsin B Activity in Individual Macropinosomes
Anal Chem95, 11410-11419. PubMed Europe PubMed DOI
Katsumata-Kato,O., Yokoyama,M. and Fujita-Yoshigaki,J.
The secretory ability of newly formed secretory granules is regulated by pro-cathepsin B and amylase in parotid glands
Biochem Biophys Res Commun666, 45-51. PubMed Europe PubMed DOI
Li,X., Zhang,M., Zhang,H., Wang,Z. and Zhang,H.
Upconversion nanoparticle-based fluorescence resonance energy transfer sensing platform for the detection of cathepsin B activity in vitro and in vivo
Mikrochim Acta190, 181-181. PubMed Europe PubMed DOI
Ma,Y., Shang,J., Liu,L., Li,M., Xu,X., Cao,H., Xu,L., Sun,W., Song,G. and Zhang,X.B.
Rational Design of a Double-Locked Photoacoustic Probe for Precise In Vivo Imaging of Cathepsin B in Atherosclerotic Plaques
J Am Chem Soc145, 17881-17891. PubMed Europe PubMed DOI
Nguyen,T., Kumar,R.P. and Park,P.H.
Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes
Arch Pharm Res46, 160-176. PubMed Europe PubMed DOI
Shang,X.K., Zhang,S.M. and Ni,J.J.
Research progress of cathepsin B in brain aging and Alzheimer's diseases
Yi Chuan45, 212-220. PubMed Europe PubMed DOI V
Stoka,V., Vasiljeva,O., Nakanishi,H. and Turk,V.
The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer
Int J Mol Sci24, PubMed Europe PubMed DOI V
Tusar,L., Loboda,J., Impens,F., Sosnowski,P., Van Quickelberghe,E., Vidmar,R., Demol,H., Sedeyn,K., Saelens,X., Vizovisek,M., Mihelic,M., Fonovic,M., Horvat,J., Kosec,G., Turk,B., Gevaert,K. and Turk,D.
Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins
Commun Biol6, 450-450. PubMed Europe PubMed DOI
Wu,Y., Mumford,P., Noy,S., Cleverley,K., Mrzyglod,A., Luo,D., van Dalen,F., Verdoes,M., Fisher,E.M.C. and Wiseman,F.K.
Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B
Acta Neuropathol Commun11, 132-132. PubMed Europe PubMed DOI
Xie,Z., Zhao,M., Yan,C., Kong,W., Lan,F., Narengaowa, Zhao,S., Yang,Q., Bai,Z., Qing,H. and Ni,J.
Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways
Cell Death Dis14, 255-255. PubMed Europe PubMed DOI V
Yoon,M.C., Phan,V., Podvin,S., Mosier,C., O'Donoghue,A.J. and Hook,V.
Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range
Biochemistry62, 2289-2300. PubMed Europe PubMed DOI

2022

Gomez-Alonso,I.S., Martinez-Garcia,S., Betanzos-Cabrera,G., Juarez,E., Sarabia-Leon,M.C., Herrera,M.T., Gomez-Chavez,F., Sanchez-Torres,L., Rodriguez-Martinez,S., Cancino-Diaz,M.E., Cancino,J. and Cancino-Diaz,J.C.
Low Concentration of the Neutrophil Proteases Cathepsin G, Cathepsin B, Proteinase-3 and Metalloproteinase-9 Induce Biofilm Formation in Non-Biofilm-Forming Staphylococcus epidermidis Isolates
Int J Mol Sci23, PubMed Europe PubMed DOI
Hook,G., Reinheckel,T., Ni,J., Wu,Z., Kindy,M., Peters,C. and Hook,V.
Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders
Pharmacol Rev74, 600-629. PubMed Europe PubMed DOI V
Ni,J., Lan,F., Xu,Y., Nakanishi,H. and Li,X.
Extralysosomal cathepsin B in central nervous system: Mechanisms and therapeutic implications
Brain Pathole13071-e13071. PubMed Europe PubMed DOI V
Yan,W., Feng,Y., Lei,Z., Kuang,W. and Long,C.
MicroRNA-214-3p Ameliorates LPS-Induced Cardiomyocyte Injury by Inhibiting Cathepsin B
Folia Biol (Praha)68, 78-85. PubMed Europe PubMed
Yang,X., Yin,H., Zhang,D., Peng,L., Li,K., Cui,F., Xia,C., Li,Z. and Huang,H.
Bibliometric Analysis of Cathepsin B Research From 2011 to 2021
Front Med (Lausanne)9, 898455-898455. PubMed Europe PubMed DOI
Yoon,M.C., Hook,V. and O'Donoghue,A.J.
Cathepsin B Dipeptidyl Carboxypeptidase and Endopeptidase Activities Demonstrated across a Broad pH Range
Biochemistry61, 1904-1914. PubMed Europe PubMed DOI
Yoon,M.C., Christy,M.P., Phan,V.V., Gerwick,W.H., Hook,G., O'Donoghue,A.J. and Hook,V.
Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B
Biochemistry61, 228-238. PubMed Europe PubMed DOI I

2021

Akinyemi,A.O., Pereira,G.B.S. and Rocha,F.V.
Role of cathepsin B in cancer progression: a potential target for coordination compounds
Mini Rev Med Chem PubMed Europe PubMed DOI V
Bollavaram,K., Leeman,T.H., Lee,M.W., Kulkarni,A., Upshaw,S.G., Yang,J., Song,H. and Platt,M.O.
Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V
Protein Sci PubMed Europe PubMed DOI
Chen,X., Ren,X., Zhu,Y., Fan,Z., Zhang,L., Liu,Z., Dong,L. and Hai,Z.
Cathepsin B-Activated Fluorescent and Photoacoustic Imaging of Tumor
Anal Chem93, 9304-9308. PubMed Europe PubMed DOI
Chitranshi,N., Kumar,A., Sheriff,S., Gupta,V., Godinez,A., Saks,D., Sarkar,S., Shen,T., Mirzaei,M., Basavarajappa,D., Abyadeh,M., Singh,S.K., Dua,K., Zhang,K.Y.J., Graham,S.L. and Gupta,V.
Identification of Novel Cathepsin B Inhibitors with Implications in Alzheimer's Disease: Computational Refining and Biochemical Evaluation
Cells10, PubMed Europe PubMed DOI
Dominguez-Hernandez,E. and Ertbjerg,P.
Effect of LTLT heat treatment on cathepsin B and L activities and denaturation of myofibrillar proteins of pork
Meat Sci175, 108454-108454. PubMed Europe PubMed DOI
Fujimoto,T., Tsunedomi,R., Matsukuma,S., Yoshimura,K., Oga,A., Fujiwara,N., Fujiwara,Y., Matsui,H., Shindo,Y., Tokumitsu,Y., Suzuki,N., Kobayashi,S., Hazama,S., Eguchi,H. and Nagano,H.
Cathepsin B is highly expressed in pancreatic cancer stem-like cells and is associated with patients' surgical outcomes
Oncol Lett21, 30-30. PubMed Europe PubMed DOI
Gu,Y., Zhu,Y., Deng,G., Liu,S., Sun,Y. and Lv,W.
Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation
Int Immunopharmacol93, 107375-107375. PubMed Europe PubMed DOI I
Huang,Y., Chen,Z., Gu,Q., Gu,Z., Wu,X. and Yu,X.
CA-074Me inhibits cathepsin-B and alleviates fibrosis after myocardial infarction
Panminerva Med63, 397-398. PubMed Europe PubMed DOI U I
IstIflI,E.S., SihoGlu Tepe,A., Netz,P.A., SarikUrkcU,C., Kilic,I.H. and Tepe,B.
Determination of the interaction between the receptor binding domain of 2019-nCoV spike protein, TMPRSS2, cathepsin B and cathepsin L, and glycosidic and aglycon forms of some flavonols
Turk J Biol45, 484-502. PubMed Europe PubMed DOI
Knopp,R.C., Jastaniah,A., Dubrovskyi,O., Gaisina,I., Tai,L. and Thatcher,G.R.J.
Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma
ACS Pharmacol Transl Sci4, 372-385. PubMed Europe PubMed DOI
Liu,L. and Doray,B.
Elevated mRNA expression and defective processing of cathepsin D in HeLa cells lacking the mannose 6-phosphate pathway
FEBS Open Bio11, 1695-1703. PubMed Europe PubMed DOI
Malla,R.R., Gopinath,S., Gondi,C.S., Alapati,K., Dinh,D.H., Tsung,A.J. and Rao,J.S.
Retraction Note to: uPAR and cathepsin B downregulation induces apoptosis by targeting calcineurin A to BAD via Bcl-2 in glioma
J Neurooncol152, 417-417. PubMed Europe PubMed DOI
Nagahama,M., Kobayashi,K., Ochi,S. and Takehara,M.
Internalization of Clostridium botulinum C2 Toxin Is Regulated by Cathepsin B Released from Lysosomes
Toxins (Basel)13, PubMed Europe PubMed DOI
Nagahama,M., Kobayashi,K. and Takehara,M.
Cathepsin Release from Lysosomes Promotes Endocytosis of Clostridium perfringens Iota-Toxin
Toxins (Basel)13, PubMed Europe PubMed DOI
Pathak,M., Vani,V. and Seshagiri,P.B.
Expression and function of interleukin-1beta is required for hamster blastocyst hatching: Involvement of hatching-associated cathepsin proteases
Mol Reprod Dev88, 274-286. PubMed Europe PubMed DOI
Shen,Y., Wu,T., Wang,Y., Zhang,S.L., Zhao,X., Chen,H.Y. and Xu,J.J.
Nucleolin-Targeted Ratiometric Fluorescent Carbon Dots with a Remarkably Large Emission Wavelength Shift for Precise Imaging of Cathepsin B in Living Cancer Cells
Anal Chem93, 4042-4050. PubMed Europe PubMed DOI
Steuten,K., Kim,H., Widen,J.C., Babin,B.M., Onguka,O., Lovell,S., Bolgi,O., Cerikan,B., Neufeldt,C.J., Cortese,M., Muir,R.K., Bennett,J.M., Geiss-Friedlander,R., Peters,C., Bartenschlager,R. and Bogyo,M.
Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19
ACS Infect Dis PubMed Europe PubMed DOI
Talukdar,R., Aslam,M., Reddy,D.N., Nabi,Z., Shava,U., Ravikanth,V.V., Avanthi,S. and Govardhan,B.
Pancreas Divisum Increases the Risk of Recurrent Acute Pancreatitis in Patients with rs12338 Polymorphism in the Cathepsin B Gene
Dig Dis Sci66, 2283-2290. PubMed Europe PubMed DOI
Tran,A.P. and Silver,J.
Cathepsins in neuronal plasticity
Neural Regen Res16, 26-35. PubMed Europe PubMed DOI
Wang,J., Wang,L., Zhang,X., Xu,Y., Chen,L., Zhang,W., Liu,E., Xiao,C. and Kou,Q.
Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis
Int Immunopharmacol94, 107496-107496. PubMed Europe PubMed DOI I
Yang,J., Chen,T. and Zhou,Y.
Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes
Hereditas158, 4-4. PubMed Europe PubMed DOI

2020

Abhinand,C.S., Nair,A.S., Krishnamurthy,A., Oommen,O.V. and Sudhakaran,P.R.
Potential protease inhibitors and their combinations to block SARS-CoV-2
J Biomol Struct Dyn1-15. PubMed Europe PubMed DOI I
Amouzadeh Tabrizi,M., Ferre-Borrull,J. and Marsal,L.F.
An optical biosensor for the determination of cathepsin B as a cancer-associated enzyme using nanoporous anodic alumina modified with human serum albumin-thionine
Mikrochim Acta187, 230-230. PubMed Europe PubMed DOI A
Anderson,M.J., Song,Y., Fan,H., Wright,J.G., Ren,Z., Hua,D.H., Koehne,J.E., Meyyappan,M. and Li,J.
Simultaneous, multiplex quantification of protease activities using a gold microelectrode array
Biosens Bioelectron165, 112330-112330. PubMed Europe PubMed DOI A
Balboula,A.Z., Schindler,K., Kotani,T., Kawahara,M. and Takahashi,M.
Vitrification-induced activation of lysosomal cathepsin B perturbs spindle assembly checkpoint function in mouse oocytes
Mol Hum Reprod PubMed Europe PubMed DOI
Carrilho,M.R., Scaffa,P., Oliveira,V., Tjaderhane,L., Tersariol,I.L., Pashley,D.H., Tay,F. and Nascimento,F.D.
Insights into cathepsin-B activity in mature dentin matrix
Arch Oral Biol117, 104830-104830. PubMed Europe PubMed DOI
Chevriaux,A., Pilot,T., Derangere,V., Simonin,H., Martine,P., Chalmin,F., Ghiringhelli,F. and Rebe,C.
Cathepsin B is required for NLRP3 inflammasome activation in macrophages, through NLRP3 interaction
Front Cell Dev Biol8, 167-167. PubMed Europe PubMed DOI
Cosgrove,J., Novkovic,M., Albrecht,S., Pikor,N.B., Zhou,Z., Onder,L., Morbe,U., Cupovic,J., Miller,H., Alden,K., Thuery,A., O'Toole,P., Pinter,R., Jarrett,S., Taylor,E., Venetz,D., Heller,M., Uguccioni,M., Legler,D.F., Lacey,C.J., Coatesworth,A., Polak,W.G., Cupedo,T., Manoury,B., Thelen,M., Stein,J.V., Wolf,M., Leake,M.C., Timmis,J., Ludewig,B. and Coles,M.C.
B cell zone reticular cell microenvironments shape CXCL13 gradient formation
Nat Commun11, 3677-3677. PubMed Europe PubMed DOI
Dai,Z., Cheng,Q. and Zhang,Y.
Rational design of a humanized antibody inhibitor of cathepsin B
Biochemistry59, 1420-1427. PubMed Europe PubMed DOI
Domagalski,J.T., Xifre-Perez,E., Tabrizi,M.A., Ferre-Borrull,J. and Marsal,L.F.
Magnetic nanoparticle decorated anodic alumina nanotubes for fluorescent detection of cathepsin B
J Colloid Interface Sci584, 236-245. PubMed Europe PubMed DOI A
Filippova,I.Y., Dvoryakova,E.A., Sokolenko,N.I., Simonyan,T.R., Tereshchenkova,V.F., Zhiganov,N.I., Dunaevsky,Y.E., Belozersky,M.A., Oppert,B. and Elpidina,E.N.
New Glutamine-Containing Substrates for the Assay of Cysteine Peptidases From the C1 Papain Family
Front Mol Biosci7, 578758-578758. PubMed Europe PubMed DOI
Hadi,M.M., Nesbitt,H., Masood,H., Sciscione,F., Patel,S., Ramesh,B.S., Emberton,M., Callan,J.F., Macrobert,A., McHale,A.P. and Nomikou,N.
Investigating the performance of a novel pH and cathepsin B sensitive, stimulus-responsive nanoparticle for optimised sonodynamic therapy in prostate cancer
J Control Release329, 76-86. PubMed Europe PubMed DOI
Han,L., Xu,D., Xi,Z., Wu,M., Nik Nabil,W.N., Zhang,J., Sui,H., Fu,W., Zhou,H., Lao,Y., Xu,G., Guo,C. and Xu,H.
The Natural Compound Oblongifolin C Exhibits Anticancer Activity by Inhibiting HSPA8 and Cathepsin B In Vitro
Front Pharmacol11, 564833-564833. PubMed Europe PubMed DOI I
Han,Y., Yue,X., Hu,C.X., Liu,F., Liu,R.D., He,M.M., Long,S.R., Cui,J. and Wang,Z.Q.
Interaction of a Trichinella spiralis cathepsin B with enterocytes promotes the larval intrusion into the cells
Res Vet Sci130, 110-117. PubMed Europe PubMed DOI
Herceg,V., Bouilloux,J., Janikowska,K., Allemann,E. and Lange,N.
Cathepsin B-Cleavable Cyclopeptidic Chemotherapeutic Prodrugs
Molecules25, PubMed Europe PubMed DOI
Hook,V., Yoon,M., Mosier,C., Ito,G., Podvin,S., Head,B.P., Rissman,R., O'Donoghue,A.J. and Hook,G.
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders
Biochim Biophys Acta Proteins Proteom140428-140428. PubMed Europe PubMed DOI
Hu,S., Gong,H., Zhu,J., Rong,Y., Zhao,Y., Lu,Y., Li,L. and Wang,J.
Molecular characterisation, tissue distribution, and expression profiling of the cathepsin b gene during ovarian follicle development in geese
Br Poult Sci PubMed Europe PubMed DOI
Izumida,M., Hayashi,H., Tanaka,A. and Kubo,Y.
Cathepsin B Protease Facilitates Chikungunya Virus Envelope Protein-Mediated Infection via Endocytosis or Macropinocytosis
Viruses12, PubMed Europe PubMed DOI K
Jaimes,J., Millet,J. and Whittaker,G.
Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site
SSRN3581359-3581359. PubMed Europe PubMed DOI
Jastaniah,A., Gaisina,I.N., Knopp,R.C. and Thatcher,G.R.J.
Synthesis of alpha-Ketoamide-Based Stereoselective Calpain-1 Inhibitors as Neuroprotective Agents
ChemMedChem PubMed Europe PubMed DOI I
Jiang,M., Meng,J., Zeng,F., Qing,H., Hook,G., Hook,V., Wu,Z. and Ni,J.
Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling
J Neurochem PubMed Europe PubMed DOI I
Jin,X., Zhang,J., Jin,X., Liu,L. and Tian,X.
Folate Receptor Targeting and Cathepsin B-Sensitive Drug Delivery System for Selective Cancer Cell Death and Imaging
ACS Med Chem Lett11, 1514-1520. PubMed Europe PubMed DOI
Kianifard,L., Yakhchali,M. and Imani,M.
The Effects of pH and Temperature on Cysteine Protease (Cathepsin B) Activity in Miracidia and Eggs of Fasciola hepatica
Iran J Parasitol15, 233-239. PubMed Europe PubMed
Kim,E.K., Song,M.J., Jang,H.H. and Chung,Y.S.
Clinicopathologic Analysis of Cathepsin B as a Prognostic Marker of Thyroid Cancer
Int J Mol Sci21, PubMed Europe PubMed DOI
Kuang,F., Liu,J., Li,C., Kang,R. and Tang,D.
Cathepsin B is a mediator of organelle-specific initiation of ferroptosis
Biochem Biophys Res Commun533, 1464-1469. PubMed Europe PubMed DOI
Li,H., Xie,L., Chen,L., Zhang,L., Han,Y., Yan,Z. and Guo,X.
Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer
Aging (Albany NY)12, 22370-22389. PubMed Europe PubMed DOI
Li,Y., He,Z., Lv,H., Chen,W. and Chen,J.
Calpain-2 plays a pivotal role in the inhibitory effects of propofol against TNF-alpha-induced autophagy in mouse hippocampal neurons
J Cell Mol Med PubMed Europe PubMed DOI
Liu,C., Cai,Z., Hu,T., Yao,Q. and Zhang,L.
Cathepsin B aggravated doxorubicininduced myocardial injury via NFkappaB signalling
Mol Med Rep22, 4848-4856. PubMed Europe PubMed DOI K
Liu,Y., Xie,Y., Lin,Y., Xu,Q., Huang,Y., Peng,M., Lai,W. and Zheng,Y.
Cepharanthine as a Potential Novel Tumor-Regional Therapy in Treating Cutaneous Melanoma: Altering the Expression of Cathepsin B, Tumor Suppressor Genes and Autophagy-Related Proteins
Front Bioeng Biotechnol8, 601969-601969. PubMed Europe PubMed DOI
Maeser,S., Petre,B.A., Ion,L., Rawer,S., Kohlschutter,A., Santorelli,F.M., Simonati,A., Schulz,A. and Przybylski,M.
Enzymatic diagnosis of neuronal lipofuscinoses in dried blood spots using substrates for concomitant tandem mass spectrometry and fluorimetry
J Mass Spectrome4675-e4675. PubMed Europe PubMed DOI
Matos,T.K.B., Batista,P.H.J., Dos Reis Rocho,F., De Vita,D., Pearce,N., Kellam,B., Montanari,C.A. and Leitao,A.
Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB
Bioorg Med Chem Lett30, 127439-127439. PubMed Europe PubMed DOI I
Mellott,D., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D., Hsu,J.C., Zhu,J., Taylor,Z., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Beck,S., Carlin,A.F., Clark,A.E., Berreta,L., Maneval,D., Frueh,F., Hurst,B.L., Wang,H., Kocurek,K.I., Raushel,F.M., O'Donoghue,A., Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H.
A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells
bioRxiv PubMed Europe PubMed DOI I
Mizunoe,Y., Kobayashi,M., Hoshino,S., Tagawa,R., Itagawa,R., Hoshino,A., Okita,N., Sudo,Y., Nakagawa,Y., Shimano,H. and Higami,Y.
Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes
Sci Rep10, 634-634. PubMed Europe PubMed DOI
Morrone,C., Smirnova,N.F., Jeridi,A., Kneidinger,N., Hollauer,C., Schupp,J.C., Kaminski,N., Jenne,D., Eickelberg,O. and Yildirim,A.O.
Cathepsin B promotes collagen biosynthesis driving Bronchiolitis Obliterans Syndrome
Eur Respir J PubMed Europe PubMed DOI
Nagakannan,P., Islam,M.I., Conrad,M. and Eftekharpour,E.
Cathepsin B is an executioner of ferroptosis
Biochim Biophys Acta Mol Cell Res1868, 118928-118928. PubMed Europe PubMed DOI
Nakanishi,H., Nonaka,S. and Wu,Z.
Microglial cathepsin B and Porphyromonas gingivalis gingipains as potential therapeutic targets for sporadic Alzheimer's disease
CNS Neurol Disord Drug Targets PubMed Europe PubMed DOI
Nakanishi,H.
Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging
Neural Regen Res15, 25-29. PubMed Europe PubMed DOI
Nettesheim,A., Shim,M.S., Dixon,A., Raychaudhuri,U., Gong,H. and Liton,P.B.
Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma
J Clin Med10, PubMed Europe PubMed DOI
Niu,R., Wang,J., Geng,C., Li,Y., Dong,L., Liu,L., Chang,Y., Shen,J., Nie,Z., Zhang,Y. and Hu,B.
Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy
Aging (Albany NY)12, PubMed Europe PubMed DOI
Oberstein,T.J., Utz,J., Spitzer,P., Klafki,H.W., Wiltfang,J., Lewczuk,P., Kornhuber,J. and Maler,J.M.
The Role of Cathepsin B in the Degradation of Abeta and in the Production of Abeta Peptides Starting With Ala2 in Cultured Astrocytes
Front Mol Neurosci13, 615740-615740. PubMed Europe PubMed DOI
Padmanabhan,P., Desikan,R. and Dixit,N.M.
Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection
PLoS Comput Biol16, e1008461-e1008461. PubMed Europe PubMed DOI
Peintner,L., Venkatraman,A., Waeldin,A., Hofherr,A., Busch,T., Voronov,A., Viau,A., Kuehn,E.W., Kottgen,M. and Borner,C.
Loss of PKD1/polycystin-1 impairs lysosomal activity in a CAPN (calpain)-dependent manner
Autophagy1-17. PubMed Europe PubMed DOI I
Riaz,S., Abdulrahman,N., Uddin,S., Jabeen,A., Gadeau,A.P., Fliegel,L. and Mraiche,F.
Anti-hypertrophic effect of Na(+)/H(+) exchanger-1 inhibition is mediated by reduced cathepsin B
Eur J Pharmacol888, 173420-173420. PubMed Europe PubMed DOI I
Seth,S., Batra,J. and Srinivasan,S.
COVID-19: Targeting Proteases in Viral Invasion and Host Immune Response
Front Mol Biosci7, 215-215. PubMed Europe PubMed DOI V
Sharma,C. and Kang,S.C.
Molecular dynamic simulation (MDS) and in vitro cathepsin-B inhibitory activity of decrusin angelate, ibuprofen, and thymol
Nat Prod Res1-6. PubMed Europe PubMed DOI
Sharma,T., Harioudh,M.K., Kuldeep,J., Kumar,S., Banerjee,D., Ghosh,J.K. and Siddiqi,M.I.
Identification of potential inhibitors of cathepsin-B using shape & pharmacophore-based virtual screening, molecular docking and explicit water thermodynamics
Mol Inform39, e1900023-e1900023. PubMed Europe PubMed DOI I
Ulcakar,L. and Novinec,M.
Inhibition of Human Cathepsins B and L by Caffeic Acid and Its Derivatives
Biomolecules11, PubMed Europe PubMed DOI
Van de Walle,T., Briand,M., Mitrovic,A., Sosic,I., Gobec,S., Kos,J., Persoons,L., Daelemans,D., De Jonghe,S., Ubiparip,Z., Desmet,T., Van Hecke,K., Mangelinckx,S. and D'hooghe,M.
Synthesis of Novel Nitroxoline Analogs with Potent Cathepsin B Exopeptidase Inhibitory Activity
ChemMedChem15, 2477-2490. PubMed Europe PubMed DOI I
Viana,G.M., Gonzalez,E.A., Alvarez,M.M.P., Cavalheiro,R.P., do Nascimento,C.C., Baldo,G., D'Almeida,V., de Lima,M.A., Pshezhetsky,A.V. and Nader,H.B.
Cathepsin B-associated activation of amyloidogenic pathway in murine mucopolysaccharidosis type I brain cortex
Int J Mol Sci21, PubMed Europe PubMed DOI
Voisin,A., Monville,C., Plancheron,A., Bere,E., Gaillard,A. and Leveziel,N.
Corrigendum to "Cathepsin B pH-Dependent Activity Is Involved in Lysosomal Dysregulation in Atrophic Age-Related Macular Degeneration"
Oxid Med Cell Longev2020, 3510764-3510764. PubMed Europe PubMed DOI
Wang,H., Wang,Z., Wang,L., Sun,L., Liu,W., Li,Q. and Wang,J.
IL-6 promotes collagen-induced arthritis by activating the NLRP3 inflammasome through the cathepsin B/S100A9-mediated pathway
Int Immunopharmacol88, 106985-106985. PubMed Europe PubMed DOI
Wang,R., Liu,J., Di Giuseppe,G. and Liang,A.
UAA and UAG may encode amino acid in cathepsin B gene of Euplotes octocarinatus
J Eukaryot Microbiol67, 144-149. PubMed Europe PubMed DOI
Wang,S.J., Chao,D., Wei,W., Nan,G., Li,J.Y., Liu,F.L., Li,L., Jiang,J.L., Cui,H.Y. and Chen,Z.N.
CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma
J Exp Clin Cancer Res39, 145-145. PubMed Europe PubMed DOI
Wang,Y., Jiang,L., Zhang,Y., Lu,Y., Li,J., Wang,H., Yao,D. and Wang,D.
Fibronectin-Targeting and Cathepsin B-Activatable Theranostic Nanoprobe for MR/Fluorescence Imaging and Enhanced Photodynamic Therapy for Triple Negative Breast Cancer
ACS Appl Mater Interfaces12, 33564-33574. PubMed Europe PubMed DOI
Wang,Z.Y., Zhang,C.P. and Zhang,C.Y.
Integration of a peptide-DNA conjugate with multiple cyclic signal amplification for the ultrasensitive detection of cathepsin B activity
Chem Commun (Camb)56, 2119-2122. PubMed Europe PubMed DOI A
Yu,C., Wan,Y., Piao,L. and Wu Cheng,X.
Can cysteinyl cathepsin activity control diet-induced NAFLD?
Int J Cardiol Heart Vasc28, 100516-100516. PubMed Europe PubMed DOI
Zhao,X.D., Zhang,B.W., Fu,L.J., Li,Q.L., Lin,Y. and Yu,X.Q.
Possible insecticidal mechanism of Cry41-related toxin against Myzus persicae by enhancing cathepsin B activity
J Agric Food Chem68, 4607-4615. PubMed Europe PubMed DOI

2019

Cantres-Rosario,Y.M., Ortiz-Rodriguez,S.C., Santos-Figueroa,A.G., Plaud,M., Negron,K., Cotto,B., Langford,D. and Melendez,L.M.
HIV Infection induces extracellular cathepsin B uptake and damage to neurons
Sci Rep9, 8006-8006. PubMed Europe PubMed DOI
Chen,C.H., Bhasin,S., Khanna,P., Joshi,M., Joslin,P.M., Saxena,R., Amin,S., Liu,S., Sindhu,S., Walker,S.R., Catalano,P., Frank,D.A., Alper,S.L., Bhasin,M. and Bhatt,R.S.
Study of cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts
Oncogenesis8, 15-15. PubMed Europe PubMed DOI
Cui,J., Han,Y., Yue,X., Liu,F., Song,Y.Y., Yan,S.W., Lei,J.J., Zhang,X., Jiang,P. and Wang,Z.Q.
Vaccination of mice with a recombinant novel cathepsin B inhibits Trichinella spiralis development, reduces the fecundity and worm burden
Parasit Vectors12, 581-581. PubMed Europe PubMed DOI
Demcsak,A., Geisz,A. and Sahin-Toth,M.
Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B
Sci Rep9, 9188-9188. PubMed Europe PubMed DOI
Dheer,D., Nicolas,J. and Shankar,R.
Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases
Adv Drug Deliv Rev151-152, 130-151. PubMed Europe PubMed DOI V
Karnthaler-Benbakka,C., Koblmuller,B., Mathuber,M., Holste,K., Berger,W., Heffeter,P., Kowol,C.R. and Keppler,B.K.
Synthesis, characterization and in vitro studies of a cathepsin B-cleavable prodrug of the VEGFR inhibitor Sunitinib
Chem Biodivers16, e1800520-e1800520. PubMed Europe PubMed DOI
Mitrovic,A., Kljun,J., Sosic,I., Ursic,M., Meden,A., Gobec,S., Kos,J. and Turel,I.
Organoruthenated nitroxoline derivatives impair tumor cell invasion through inhibition of cathepsin B activity
Inorg Chem58, 12334-12347. PubMed Europe PubMed DOI I
Ni,Y., Hai,Z., Zhang,T., Wang,Y., Yang,Y., Zhang,S. and Liang,G.
Cathepsin B turning bioluminescence "on" for tumor imaging
Anal Chem91, 14834-14837. PubMed Europe PubMed DOI L
Pandey,G., Bakhshi,S., Kumar,M., Thakur,B., Jain,P., Kaur,P. and Chauhan,S.S.
Prognostic and therapeutic relevance of cathepsin B in pediatric acute myeloid leukemia
Am J Cancer Res9, 2634-2649. PubMed Europe PubMed
Poreba,M., Groborz,K., Vizovisek,M., Maruggi,M., Turk,D., Turk,B., Powis,G., Drag,M. and Salvesen,G.S.
Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples
Chem Sci10, 8461-8477. PubMed Europe PubMed DOI L
Schmitz,J., Gilberg,E., Loser,R., Bajorath,J., Bartz,U. and Gutschow,M.
Cathepsin B: active site mapping with peptidic substrates and inhibitors
Bioorg Med Chem27, 1-15. PubMed Europe PubMed DOI
Schwenck,J., Maurer,A., Fehrenbacher,B., Mehling,R., Knopf,P., Mucha,N., Haupt,D., Fuchs,K., Griessinger,C.M., Bukala,D., Holstein,J., Schaller,M., Menendez,I.G., Ghoreschi,K., Quintanilla-Martinez,L., Gutschow,M., Laufer,S., Reinheckel,T., Rocken,M., Kalbacher,H., Pichler,B.J. and Kneilling,M.
Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions
Theranostics9, 3903-3917. PubMed Europe PubMed DOI K
Shim,M.K., Park,J., Yoon,H.Y., Lee,S., Um,W., Kim,J.H., Kang,S.W., Seo,J.W., Hyun,S.W., Park,J.H., Byun,Y., Kwon,I.C. and Kim,K.
Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy
J Control Release294, 376-389. PubMed Europe PubMed DOI
Singh,G., Jayadev Magani,S.K., Sharma,R., Bhat,B., Shrivastava,A., Chinthakindi,M. and Singh,A.
Structural, functional and molecular dynamics analysis of cathepsin B gene SNPs associated with tropical calcific pancreatitis, a rare disease of tropics
PeerJ7, e7425-e7425. PubMed Europe PubMed DOI M
Sung,S.A., Kim,D.H., Oh,K.H., Han,S.Y. and Han,K.H.
The role of cathepsin B in peritoneal fibrosis due to peritoneal dialysis
Int J Nephrol2019, 4150656-4150656. PubMed Europe PubMed DOI U
Toupin,N.P., Arora,K., Shrestha,P., Peterson,J.A., Fischer,L.J., Rajagurubandara,E., Podgorski,I., Winter,A.H. and Kodanko,J.J.
BODIPY-Caged photoactivated inhibitors of cathepsin B flip the light switch on cancer cell apoptosis
ACS Chem Biol14, 2833-2840. PubMed Europe PubMed DOI I
Voisin,A., Monville,C., Plancheron,A., Bere,E., Gaillard,A. and Leveziel,N.
Cathepsin B pH-dependent activity is involved in lysosomal dysregulation in atrophic age-related macular degeneration
Oxid Med Cell Longev2019, 5637075-5637075. PubMed Europe PubMed DOI
Wang,Q., Yu,L., Wong,R.C.H. and Lo,P.C.
Construction of cathepsin B-responsive fluorescent probe and photosensitizer using a ferrocenyl boron dipyrromethene dark quencher
Eur J Med Chem179, 828-836. PubMed Europe PubMed DOI A L
Wang,S., Vigliarolo,B.G., Chowdhury,M.A., Nyarko,J.N.K., Mousseau,D.D. and Phenix,C.P.
Design and synthesis of fluorogenic substrate-based probes for detecting cathepsin B activity
Bioorg Chem92, 103194-103194. PubMed Europe PubMed DOI A L
Wrona,E., Jakubowska,J., Pawlik,B., Pastorczak,A., Madzio,J., Lejman,M., Sedek,L., Kowalczyk,J., Szczepanski,T. and Mlynarski,W.
Gene expression of ASNS, LGMN and CTSB is elevated in a subgroup of childhood BCP-ALL with PAX5 deletion
Oncol Lett18, 6926-6932. PubMed Europe PubMed DOI
Wu,J.S., Li,Z.F., Wang,H.F., Yu,X.H., Pang,X., Wu,J.B., Wang,S.S., Zhang,M., Yang,X., Cao,M.X., Tang,Y.J., Liang,X.H., Zheng,M. and Tang,Y.L.
Cathepsin B defines leader cells during the collective invasion of salivary adenoid cystic carcinoma
Int J Oncol54, 1233-1244. PubMed Europe PubMed DOI T
Zhang,F., Lyon,C.J., Walls,R.J., Ning,B., Fan,J. and Hu,T.Y.
Cathepsin B dependent cleavage product of serum amyloid A1 identifies patients with chemotherapy-related cardiotoxicity
ACS Pharmacol Transl Sci2, 333-341. PubMed Europe PubMed DOI
Zhang,Y., Chen,Y., Zhang,Y., Li,P.L. and Li,X.
Contribution of cathepsin B-dependent Nlrp3 inflammasome activation to nicotine-induced endothelial barrier dysfunction
Eur J Pharmacol172795-172795. PubMed Europe PubMed DOI
Zheng,L., Wu,X., Li,S., Liu,B. and Xue,D.
Cathepsin B inhibitors block multiple radiation-induced side effects in C. elegans
Cell Res29, 1042-1045. PubMed Europe PubMed DOI I

2018

Aghdassi,A.A., John,D.S., Sendler,M., Weiss,F.U., Reinheckel,T., Mayerle,J. and Lerch,M.M.
Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis
J Biol Chem293, 1018-1029. PubMed Europe PubMed DOI
Araujo,T.F., Cordeiro,A.V., Vasconcelos,D.A.A., Vitzel,K.F. and Silva,V.R.R.
The role of cathepsin B in autophagy during obesity: a systematic review
Life Sci209, 274-281. PubMed Europe PubMed DOI
Bernstein,H.G. and Keilhoff,G.
Putative roles of cathepsin B in Alzheimer's disease pathology: the good, the bad, and the ugly in one?
Neural Regen Res13, 2100-2101. PubMed Europe PubMed DOI
Chen,N., Ou,Z., Zhang,W., Zhu,X., Li,P. and Gong,J.
Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells
Cell Prolife12487-e12487. PubMed Europe PubMed DOI
Coleman,M.D., Ha,S.D., Haeryfar,S.M.M., Barr,S.D. and Kim,S.O.
Cathepsin B plays a key role in optimal production of the influenza A virus
J Virol Antivir Res2018, 1-20. PubMed Europe PubMed DOI I
Dietze,R., Starzinski-Powitz,A., Scheiner-Bobis,G., Tinneberg,H.R., Meinhold-Heerlein,I. and Konrad,L.
Lysophosphatidic acid triggers cathepsin B-mediated invasiveness of human endometriotic cells
Biochim Biophys Acta Mol Cell Biol Lipids1863, 1369-1377. PubMed Europe PubMed DOI I
Feng,P., Zhu,W., Chen,N., Li,P., He,K. and Gong,J.
[Cathepsin B in hepatic Kupffer cells regulates activation of TLR4-independent inflammatory pathways in mice with lipopolysaccharide-induced sepsis]
Nan Fang Yi Ke Da Xue Xue Bao38, 1465-1471. PubMed Europe PubMed DOI
Gnanamony,M. and Gondi,C.S.
Targeting the expression of cathepsin B using CRISPR/Cas9 system in mammalian cancer cells
Methods Mol Biol1731, 123-131. PubMed Europe PubMed DOI K
Gonzalez,E.A., Martins,G.R., Tavares,A.M.V., Viegas,M., Poletto,E., Giugliani,R., Matte,U. and Baldo,G.
Cathepsin B inhibition attenuates cardiovascular pathology in mucopolysaccharidosis I mice
Life Sci196, 102-109. PubMed Europe PubMed DOI I
Hartmann,S., Lopez Cruz,R., Alameh,S., Ho,C.C., Rabideau,A., Pentelute,B.L., Bradley,K.A. and Martchenko,M.
Characterization of novel piperidine-based inhibitor of cathepsin B-dependent bacterial toxins and viruses
ACS Infect Dis4, 1235-1245. PubMed Europe PubMed DOI I
Kumar,A., Daitsh,Y., Ben-Aderet,L., Qiq,O., Elayyan,J., Batshon,G., Reich,E., Maatuf,Y.H., Engel,S. and Dvir-Ginzberg,M.
A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage
J Cell Sci131, jcs214973-jcs214973. PubMed Europe PubMed DOI
Liang,F.R., He,H.S., Zhang,C.W., Xu,X.M., Zeng,Z.P., Yuan,J.P., Hong,Y.H. and Wang,J.H.
Molecular cloning and functional characterization of cathepsin B from Nile tilapia (Oreochromis niloticus)
Int J Biol Macromol116, 71-83. PubMed Europe PubMed DOI
Liang,S., Jiang,H., Shen,X.H., Zhang,J.B. and Kim,N.H.
Inhibition of cathepsin B activity prevents deterioration in the quality of in vitro aged porcine oocytes
Theriogenology116, 103-111. PubMed Europe PubMed DOI I
Llorente,P., Kristen,H., Sastre,I., Toledano-Zaragoza,A., Aldudo,J., Recuero,M. and Bullido,M.J.
A free radical-generating system regulates amyloid oligomers: involvement of cathepsin B
J Alzheimers Dis66, 1397-1408. PubMed Europe PubMed DOI I
Nakao,S., Zandi,S., Sun,D. and Hafezi-Moghadam,A.
Cathepsin B-mediated CD18 shedding regulates leukocyte recruitment from angiogenic vessels
FASEB J32, 143-154. PubMed Europe PubMed DOI
Onming,S., Thongda,W., Li,C., Sawatdichaikul,O., McMillan,N., Klinbunga,S., Peatman,E. and Poompuang,S.
Bioinformatics characterization of a cathepsin B transcript from the giant river prawn, Macrobrachium rosenbergii: Homology modeling and expression analysis after Aeromonas hydrophila infection
Comp Biochem Physiol B Biochem Mol Biol221-222, 18-28. PubMed Europe PubMed DOI
Ryan,L.S. and Lippert,A.R.
Ultrasensitive chemiluminescent detection of cathepsin B: insights into the new frontier of chemiluminescent imaging
Angew Chem Int Ed Engl57, 622-624. PubMed Europe PubMed DOI L
Sendler,M., Weiss,F.U., Golchert,J., Homuth,G., van den Brandt,C., Mahajan,U.M., Partecke,L.I., Doring,P., Gukovsky,I., Gukovskaya,A.S., Wagh,P.R., Lerch,M.M. and Mayerle,J.
Cathepsin B-mediated activation of trypsinogen in endocytosing macrophages increases severity of pancreatitis in mice
Gastroenterology154, 704-718. PubMed Europe PubMed DOI
Sosic,I., Mitrovic,A., Curic,H., Knez,D., Brodnik Zugelj,H., Stefane,B., Kos,J. and Gobec,S.
Cathepsin B inhibitors: further exploration of the nitroxoline core
Bioorg Med Chem Lett28, 1239-1247. PubMed Europe PubMed DOI I
Sun,Y., Carandang,R.R., Harada,Y., Okada,S., Yoshitake,K., Asakawa,S., Nogi,Y., Matsunaga,S. and Takada,K.
Lactomycins A-C, dephosphorylated phoslactomycin derivatives that inhibit cathepsin B, from the marine-derived Streptomyces sp. ACT232
Mar Drugs16, PubMed Europe PubMed DOI I
Templeman,N.M., Luo,S., Kaletsky,R., Shi,C., Ashraf,J., Keyes,W. and Murphy,C.T.
Insulin signaling regulates oocyte quality maintenance with age via cathepsin B activity
Curr Biol28, 753-760. PubMed Europe PubMed DOI
Thibeaux,S., Siddiqi,S., Zhelyabovska,O., Moinuddin,F., Masternak,M.M. and Siddiqi,S.A.
Cathepsin B regulates hepatic lipid metabolism by cleaving liver fatty acid-binding protein
J Biol Chem293, 1910-1923. PubMed Europe PubMed DOI
Tran,A.P., Sundar,S., Yu,M., Lang,B.T. and Silver,J.
Modulation of receptor protein tyrosine phosphatase sigma increases chondroitin sulfate proteoglycan degradation through cathepsin B secretion to enhance axon outgrowth
J Neurosci38, 5399-5414. PubMed Europe PubMed DOI U
Wang,H.L., Cheng,X., Ding,S.W., Wang,D.W., Chen,C., Xu,C.L. and Xie,H.
Molecular identification and functional characterization of the cathepsin B gene (Ab-cb-1) in the plant parasitic nematode Aphelenchoides besseyi
PLoS ONE13, e0199935-e0199935. PubMed Europe PubMed DOI
Wang,Y., Jia,L., Shen,J., Wang,Y., Fu,Z., Su,S.A., Cai,Z., Wang,J.A. and Xiang,M.
Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis
PLoS Pathog14, e1006872-e1006872. PubMed Europe PubMed DOI
Wei,B., Gunzner-Toste,J., Yao,H., Wang,T., Wang,J., Xu,Z., Chen,J., Wai,J., Nonomiya,J., Tsai,S.P., Chuh,J., Kozak,K.R., Liu,Y., Yu,S.F., Lau,J., Li,G., Phillips,G.D., Leipold,D., Kamath,A., Su,D., Xu,K., Eigenbrot,C., Steinbacher,S., Ohri,R., Raab,H., Staben,L.R., Zhao,G., Flygare,J.A., Pillow,T.H., Verma,V., Masterson,L.A., Howard,P.W. and Safina,B.
Discovery of peptidomimetic antibody-drug conjugate linkers with enhanced protease specificity
J Med Chem61, 989-1000. PubMed Europe PubMed DOI
Yi,P., Hu,X., Hu,B., Wen,C. and Li,Z.
Identification and expression of cathepsin B from the freshwater mussel Cristaria plicata
Comp Biochem Physiol B Biochem Mol Biol225, 21-28. PubMed Europe PubMed DOI
Zhang,X., Wang,X., Xu,S., Li,X. and Ma,X.
Cathepsin B contributes to radioresistance by enhancing homologous recombination in glioblastoma
Biomed Pharmacother107, 390-396. PubMed Europe PubMed DOI

2017

Akenhead,M.L., Fukuda,S., Schmid-Schonbein,G.W. and Shin,H.Y.
Fluid shear-induced cathepsin B release in the control of Mac1-dependent neutrophil adhesion
J Leukoc Biol102, 117-126. PubMed Europe PubMed DOI
Caculitan,N.G., Dela Cruz Chuh,J., Ma,Y., Zhang,D., Kozak,K.R., Liu,Y., Pillow,T.H., Sadowsky,J., Cheung,T.K., Phung,Q., Haley,B., Lee,B.C., Akita,R.W., Sliwkowski,M.X. and Polson,A.G.
Cathepsin B is dispensable for cellular processing of cathepsin B-cleavable antibody-drug conjugates
Cancer Res77, 7027-7037. PubMed Europe PubMed DOI
Chen,H., Lv,M., Lv,Z., Li,C., Xu,W., Zhang,W., Zhao,X., Duan,X. and Jin,C.
Molecular cloning and functional characterization of cathepsin B from the sea cucumber Apostichopus japonicus
Fish Shellfish Immunol60, 447-457. PubMed Europe PubMed DOI
Chen,X., Lee,D., Yu,S., Kim,G., Lee,S., Cho,Y., Jeong,H., Nam,K.T. and Yoon,J.
In vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe
Biomaterials122, 130-140. PubMed Europe PubMed DOI L
Embury,C.M., Dyavarshetty,B., Lu,Y., Wiederin,J.L., Ciborowski,P., Gendelman,H.E. and Kiyota,T.
Cathepsin B improves beta-amyloidosis and learning and memory in models of Alzheimer's disease
J Neuroimmune Pharmacol12, 340-352. PubMed Europe PubMed DOI U
Farizatto,K.L.G., Ikonne,U.S., Almeida,M.F., Ferrari,M.F.R. and Bahr,B.A.
Abeta42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: evidence for protective crosstalk between protein clearance pathways
PLoS ONE12, e0182895-e0182895. PubMed Europe PubMed DOI I
Kramer,L., Renko,M., Zavrsnik,J., Turk,D., Seeger,M.A., Vasiljeva,O., Grutter,M.G., Turk,V. and Turk,B.
Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin
Theranostics7, 2806-2821. PubMed Europe PubMed DOI L
Li,S.H., Li,R., Zhong,H.X., Chen,X.H., Liu,A.P., Yang,J., Hu,Q., Ke,Q.Q. and Li,M.L.
Immunolocalization of Jian carp (Cyprinus carpio var. Jian) cathepsin B: cloning, expression, characterization, and antibody preparation
J Food Sci82, 1092-1100. PubMed Europe PubMed DOI
Li,Y.Y., Fang,J. and Ao,G.Z.
Cathepsin B and L inhibitors: a patent review (2010 - present)
Expert Opin Ther Pat27, 643-656. PubMed Europe PubMed DOI V I
Mitrovic,A., Sosic,I., Kos,S., Tratar,U.L., Breznik,B., Kranjc,S., Mirkovic,B., Gobec,S., Lah,T., Sersa,G. and Kos,J.
Addition of 2-(ethylamino)acetonitrile group to nitroxoline results in significantly improved anti-tumor activity in vitro and in vivo
Oncotarget8, 59136-59147. PubMed Europe PubMed DOI I
Ngcungcu,T., Oti,M., Sitek,J.C., Haukanes,B.I., Linghu,B., Bruccoleri,R., Stokowy,T., Oakeley,E.J., Yang,F., Zhu,J., Sultan,M., Schalkwijk,J., van Vlijmen-Willems,I.M.J.J., von der Lippe,C., Brunner,H.G., Ersland,K.M., Grayson,W., Buechmann-Moller,S., Sundnes,O., Nirmala,N., Morgan,T.M., van Bokhoven,H., Steen,V.M., Hull,P.R., Szustakowski,J., Staedtler,F., Zhou,H., Fiskerstrand,T. and Ramsay,M.
Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families
Am J Hum Genet100, 737-750. PubMed Europe PubMed DOI M
Oh,S.S., Park,S., Lee,K.W., Madhi,H., Park,S.G., Lee,H.G., Cho,Y.Y., Yoo,J. and Dong Kim,K.
Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation
Cell Death Dis8, e2729-e2729. PubMed Europe PubMed DOI
Reinheckel,T.
New kid on the block
Theranostics7, 2965-2967. PubMed Europe PubMed DOI
Roth-Konforti,M.E., Bauer,C.R. and Shabat,D.
Unprecedented sensitivity in a probe for monitoring cathepsin B: chemiluminescence microscopy cell-imaging of a natively expressed enzyme
Angew Chem Int Ed Engl56, 15633-15638. PubMed Europe PubMed DOI A L
Shoji,A., Suenaga,Y., Hosaka,A., Ishida,Y., Yanagida,A. and Sugawara,M.
Inhibitory assay for degradation of collagen IV by cathepsin B with a surface plasmon resonance sensor
J Pharm Biomed Anal145, 79-83. PubMed Europe PubMed DOI I
Wu,Z., Ni,J., Liu,Y., Teeling,J.L., Takayama,F., Collcutt,A., Ibbett,P. and Nakanishi,H.
Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice
Brain Behav Immun65, 350-361. PubMed Europe PubMed DOI I
Yang,K.M., Bae,E., Ahn,S.G., Pang,K., Park,Y., Park,J., Lee,J., Ooshima,A., Park,B., Kim,J., Jung,Y., Takahashi,S., Jeong,J., Park,S.H. and Kim,S.J.
Co-chaperone BAG2 determines the pro-oncogenic role of cathepsin B in triple-negative breast cancer cells
Cell Rep21, 2952-2964. PubMed Europe PubMed DOI
Zhang,X., Yang,X., Wang,H., Li,S., Guo,K., Jiang,D., Xiao,J. and Liang,D.
Design, synthesis, and structure-activity relationship study of epoxysuccinyl-peptide derivatives as cathepsin B inhibitors
Biol Pharm Bull40, 1240-1246. PubMed Europe PubMed DOI I

2016

Akkari,L., Gocheva,V., Quick,M.L., Kester,J.C., Spencer,A.K., Garfall,A.L., Bowman,R.L. and Joyce,J.A.
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer
Genes Dev30, 220-232. PubMed Europe PubMed DOI K
Bian,B., Mongrain,S., Cagnol,S., Langlois,M.J., Boulanger,J., Bernatchez,G., Carrier,J.C., Boudreau,F. and Rivard,N.
Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis
Mol Carcinog55, 671-687. PubMed Europe PubMed DOI
Castro-Gomes,T., Corrotte,M., Tam,C. and Andrews,N.W.
Plasma membrane repair is regulated extracellularly by proteases released from lysosomes
PLoS ONE11, e0152583-e0152583. PubMed Europe PubMed DOI
Coman,A.G., Paraschivescu,C.C., Hadade,N.D., Juncu,A., Vlaicu,O., Popescu,C.-I. and Matache,M.
New acyloxymethyl ketones: useful probes for cysteine protease profiling
Synthesis48, 3917-3923. DOI I
Dai,L.S., Sun,Y., Sun,Y.X., Zhu,B.J. and Liu,C.L.
Characterization and function of a cathepsin B in red crayfish (Procambarus clarkii) following lipopolysaccharide challenge
Fish Shellfish Immunol56, 162-168. PubMed Europe PubMed DOI
de Castro,M.A., Bunt,G. and Wouters,F.S.
Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes
Cell Death Discov2, 16012-16012. PubMed Europe PubMed DOI
Dinnes,D.L., White,M.Y., Kockx,M., Traini,M., Hsieh,V., Kim,M.J., Hou,L., Jessup,W., Rye,K.A., Thaysen-Andersen,M., Cordwell,S.J. and Kritharides,L.
Human macrophage cathepsin B-mediated C-terminal cleavage of apolipoprotein A-I at Ser228 severely impairs antiatherogenic capacity
FASEB J30, 4239-4255. PubMed Europe PubMed DOI P
Fan,P.W., Zhang,D., Halladay,J.S., Driscoll,J.P. and Khojasteh,S.C.
Going beyond common drug metabolizing enzymes: case studies of biotransformation involving aldehyde oxidase, gamma-glutamyl transpeptidase, cathepsin B, flavin-containing monooxygenase, and ADP-ribosyltransferase
Drug Metab Dispos44, 1253-1261. PubMed Europe PubMed DOI
Gikanga,B., Adeniji,N.S., Patapoff,T.W., Chih,H.W. and Yi,L.
Cathepsin B cleavage of vcMMAE-based antibody-drug conjugate is not drug location or monoclonal antibody carrier specific
Bioconjug Chem27, 1040-1049. PubMed Europe PubMed DOI
Gomez-Auli,A., Hillebrand,L.E., Biniossek,M.L., Peters,C., Reinheckel,T. and Schilling,O.
Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers
Biochimie122, 88-98. PubMed Europe PubMed DOI
Hingorani,D.V., Montano,L.A., Randtke,E.A., Lee,Y.S., Cardenas-Rodriguez,J. and Pagel,M.D.
A single diamagnetic catalyCEST MRI contrast agent that detects cathepsin B enzyme activity by using a ratio of two CEST signals
Contrast Media Mol Imaging11, 130-138. PubMed Europe PubMed DOI L
Jiang,Y., Woosley,A.N., Sivalingam,N., Natarajan,S. and Howe,P.H.
Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-beta-induced autophagy
Nat Cell Biol18, 851-863. PubMed Europe PubMed DOI
Kern,J.C., Dooney,D., Zhang,R., Liang,L., Brandish,P.E., Cheng,M., Feng,G., Beck,A., Bresson,D., Firdos,J., Gately,D., Knudsen,N., Manibusan,A., Sun,Y. and Garbaccio,R.M.
Novel phosphate modified cathepsin B linkers: improving aqueous solubility and enhancing payload scope of ADCs
Bioconjug Chem27, 2081-2088. PubMed Europe PubMed DOI
Langdon,Y.G., Fuentes,R., Zhang,H., Abrams,E.W., Marlow,F.L. and Mullins,M.C.
Split top: a maternal cathepsin B that regulates dorsoventral patterning and morphogenesis
Development143, 1016-1028. PubMed Europe PubMed DOI M
Man,S.M. and Kanneganti,T.D.
Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B
Autophagy12, 2504-2505. PubMed Europe PubMed DOI
Mitrovic,A., Kljun,J., Sosic,I., Gobec,S., Turel,I. and Kos,J.
Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity
Dalton Trans45, 16913-16921. PubMed Europe PubMed DOI I
Mitrovic,A., Mirkovic,B., Sosic,I., Gobec,S. and Kos,J.
Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion
Biol Chem397, 165-174. PubMed Europe PubMed DOI I
Niemer,M., Mehofer,U., Verdianz,M., Porodko,A., Schahs,P., Kracher,D., Lenarcic,B., Novinec,M. and Mach,L.
Nicotiana benthamiana cathepsin B displays distinct enzymatic features which differ from its human relative and aleurain-like protease
Biochimie122, 119-125. PubMed Europe PubMed DOI
Raghav,N., Jangra,S., Kumar,A., Bhattacharyya,S., Wadhwa,D. and Sindhu,J.
Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones
RSC Adv6, 34588-34599. DOI I
Schmitz,J., Li,T., Bartz,U. and Gutschow,M.
Cathepsin B inhibitors: combining dipeptide nitriles with an occluding loop recognition element by click chemistry
ACS Med Chem Lett7, 211-216. PubMed Europe PubMed DOI I
Sendler,M., Maertin,S., John,D., Persike,M., Weiss,F.U., Kruger,B., Wartmann,T., Wagh,P., Halangk,W., Schaschke,N., Mayerle,J. and Lerch,M.M.
Cathepsin B activity initiates apoptosis via digestive protease activation in pancreatic acinar cells and experimental pancreatitis
J Biol Chem291, 14717-14731. PubMed Europe PubMed DOI
Sigloch,F.C., Knopf,J.D., Weisser,J., Gomez-Auli,A., Biniossek,M.L., Petrera,A. and Schilling,O.
Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality
Biochim Biophys Acta1863, 2700-2709. PubMed Europe PubMed DOI
Talukdar,R., Sareen,A., Zhu,H., Yuan,Z., Dixit,A., Cheema,H., George,J., Barlass,U., Sah,R., Garg,S.K., Banerjee,S., Garg,P., Dudeja,V., Dawra,R. and Saluja,A.K.
Release of cathepsin B in cytosol causes cell death in acute pancreatitis
Gastroenterology151, 747-758. PubMed Europe PubMed DOI
Wang,Y., Li,J., Feng,L., Yu,J., Zhang,Y., Ye,D. and Chen,H.Y.
Lysosome-targeting fluorogenic probe for cathepsin B imaging in living cells
Anal Chem88, 12403-12410. PubMed Europe PubMed DOI L
Withana,N.P., Garland,M., Verdoes,M., Ofori,L.O., Segal,E. and Bogyo,M.
Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes
Nat Protoc11, 184-191. PubMed Europe PubMed DOI L
Withana,N.P., Ma,X., McGuire,H.M., Verdoes,M., van der Linden,W.A., Ofori,L.O., Zhang,R., Li,H., Sanman,L.E., Wei,K., Yao,S., Wu,P., Li,F., Huang,H., Xu,Z., Wolters,P.J., Rosen,G.D., Collard,H.R., Zhu,Z., Cheng,Z. and Bogyo,M.
Non-invasive imaging of idiopathic pulmonary fibrosis using cathepsin protease probes
Sci Rep6, 19755-19755. PubMed Europe PubMed DOI L
Wouters,F.S. and Bunt,G.
Cathepsin B pulls the emergency brake on cellular necrosis
Cell Death Dis7, e2170-e2170. PubMed Europe PubMed DOI

2015

Ferrara,T.F., Schneider,V.K., Kishi,L.T., Carmona,A.K., Alves,M.F., Belasque-Junior,J., Rosa,J.C., Hunter,W.B., Henrique-Silva,F. and Soares-Costa,A.
Characterization of a recombinant cathepsin B-Like cysteine peptidase from Diaphorina citri Kuwayama (Hemiptera: Liviidae): a putative target for control of citrus huanglongbing
PLoS ONE10, e0145132-e0145132. PubMed Europe PubMed DOI
Hook,G., Jacobsen,J.S., Grabstein,K., Kindy,M. and Hook,V.
Cathepsin B is a new drug target for traumatic brain injury therapeutics: evidence for E64d as a promising lead drug candidate
Front Neurol6, 178-178. PubMed Europe PubMed DOI I
Kedzior,M., Seredynski,R., Godzik,U., Tomczyk,D., Gutowicz,J., Terlecka,E., Calkosinski,I. and Terlecki,G.
Inhibition of cathepsin B activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin
Environ Sci Pollut Res Int22, 733-737. PubMed Europe PubMed DOI I
Kim,S.H., Zhao,M.H., Liang,S., Cui,X.S. and Kim,N.H.
Inhibition of cathepsin B activity reduces apoptosis by preventing cytochrome c release from mitochondria in porcine parthenotes
J Reprod Dev61, 261-268. PubMed Europe PubMed DOI I
McGlinchey,R.P. and Lee,J.C.
Cysteine cathepsins are essential in lysosomal degradation of alpha-synuclein
Proc Natl Acad Sci U S A112, 9322-9327. PubMed Europe PubMed DOI P
Ni,J., Wu,Z., Peterts,C., Yamamoto,K., Qing,H. and Nakanishi,H.
The critical role of proteolytic relay through cathepsins B and E in the phenotypic change of microglia/macrophage
J Neurosci35, 12488-12501. PubMed Europe PubMed DOI T
Ofori,L.O., Withana,N.P., Prestwood,T.R., Verdoes,M., Brady,J.J., Winslow,M.M., Sorger,J. and Bogyo,M.
Design of protease activated optical contrast agents that exploit a latent lysosomotropic effect for use in fluorescence-guided surgery
ACS Chem Biol10, 1977-1988. PubMed Europe PubMed DOI L
Ogrizek,M., Turk,S., Lesnik,S., Sosic,I., Hodoscek,M., Mirkovic,B., Kos,J., Janezic,D., Gobec,S. and Konc,J.
Molecular dynamics to enhance structure-based virtual screening on cathepsin B
J Comput Aided Mol Des29, 707-712. PubMed Europe PubMed DOI
Rajaram,K. and Nelson,D.E.
Chlamydia muridarum infection of macrophages elicits bactericidal nitric oxide production via reactive oxygen species and cathepsin B
Infect Immun83, 3164-3175. PubMed Europe PubMed DOI
Ramalho,S.D., Sharma,R., White,J.K., Aggarwal,N., Chalasani,A., Sameni,M., Moin,K., Vieira,P.C., Turro,C., Kodanko,J.J. and Sloane,B.F.
Imaging sites of inhibition of proteolysis in pathomimetic human breast cancer cultures by light-activated ruthenium compound
PLoS ONE10, e0142527-e0142527. PubMed Europe PubMed DOI L
Ramalho,S.D., De Sousa,L.R., Burger,M.C., Lima,M.I., da Silva,M.F., Fernandes,J.B. and Vieira,P.C.
Evaluation of flavonols and derivatives as human cathepsin B inhibitor
Nat Prod Res29, 2212-2214. PubMed Europe PubMed DOI I
Ruan,H., Hao,S., Young,P. and Zhang,H.
Targeting cathepsin B for cancer therapies
Horizons in Cancer Res56, 23-39.
Ruan,H., Hao,S., Young,P. and Zhang,H.
Targeting cathepsin B for cancer therapies
Horiz Cancer Res56, 23-40. PubMed Europe PubMed V U
Sbongile,M. and Soliman,M.E.
In silico identification of irreversible cathepsin B inhibitors as anti-cancer agents: virtual screening, covalent docking analysis and molecular dynamics simulations
Comb Chem High Throughput Screen18, 399-410. PubMed Europe PubMed I
Singh,M. and Raghav,N.
2,3-Dihydroquinazolin-4(1H)-one derivatives as potential non-peptidyl inhibitors of cathepsins B and H
Bioorg Chem59C, 12-22. PubMed Europe PubMed DOI I
Swisher,L.Z., Prior,A.M., Gunaratna,M.J., Shishido,S., Madiyar,F., Nguyen,T.A., Hua,D.H. and Li,J.
Quantitative electrochemical detection of cathepsin B activity in breast cancer cell lysates using carbon nanofiber nanoelectrode arrays toward identification of cancer formation
Nanomedicine11, 1695-1704. PubMed Europe PubMed DOI A
Tsujimura,A., Taguchi,K., Watanabe,Y., Tatebe,H., Tokuda,T., Mizuno,T. and Tanaka,M.
Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous alpha-synuclein fibrils
Neurobiol Dis73, 244-253. PubMed Europe PubMed DOI
Vizovisek,M., Vidmar,R., Van Quickelberghe,E., Impens,F., Andjelkovic,U., Sobotic,B., Stoka,V., Gevaert,K., Turk,B. and Fonovic,M.
Fast profiling of protease specificity reveals similar substrate specificities for cathepsins K, L and S
Proteomics15, 2479-2490. PubMed Europe PubMed DOI P
Weber,E., Barbulescu,E., Medek,R., Reinheckel,T., Sameni,M., Anbalagan,A., Moin,K. and Sloane,B.F.
Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies
Biol Chem396, 277-281. PubMed Europe PubMed DOI K
Wu,Q.Q., Xu,M., Yuan,Y., Li,F.F., Yang,Z., Liu,Y., Zhou,M.Q., Bian,Z.Y., Deng,W., Gao,L., Li,H. and Tang,Q.Z.
Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-alpha/ASK1/JNK pathway
Am J Physiol Heart Circ Physiol308, H1143-H1154. PubMed Europe PubMed DOI
Xu,Z.Z., Xiu,P., Lv,J.W., Wang,F.H., Dong,X.F., Liu,F., Li,T. and Li,J.
Integrin alphavbeta3 is required for cathepsin B-induced hepatocellular carcinoma progression
Mol Med Rep11, 3499-3504. PubMed Europe PubMed DOI
Yakovlev,A.A. and Gulyaeva,N.V.
Possible role of proteases in preconditioning of brain cells to pathological conditions
Biochemistry (Mosc)80, 163-171. PubMed Europe PubMed DOI
Yhee,J.Y., Kim,Y.J., Ryu,J.H., Yoon,H.Y., Chang,H., Park,J.H., Lee,H., Jang,H.S., Jeong,U., Kim,K. and Kang,S.W.
Cathepsin B imaging to predict quality of engineered cartilage
Macromol Biosci15, 1224-1232. PubMed Europe PubMed DOI L
Yoshida,A., Ohta,M., Kuwahara,K., Cao,M.J., Hara,K. and Osatomi,K.
Purification and characterization of cathepsin B from the muscle of horse mackerel Trachurus japonicus
Mar Drugs13, 6550-6565. PubMed Europe PubMed DOI
Zenon,F., Cantres-Rosario,Y., Adiga,R., Gonzalez,M., Rodriguez-Franco,E., Langford,D. and Melendez,L.M.
HIV-infected microglia mediate cathepsin B-induced neurotoxicity
J Neurovirol21, 544-558. PubMed Europe PubMed DOI
Zhou,Z.J., Qiu,R. and Zhang,J.
Molecular characterization of the cathepsin B of turbot (Scophthalmus maximus)
Fish Physiol Biochem41, 473-483. PubMed Europe PubMed DOI
Zhu,W., Tao,L., Quick,M.L., Joyce,J.A., Qu,J.M. and Luo,Z.Q.
Sensing cytosolic RpsL by macrophages induces lysosomal cell death and termination of bacterial infection
PLoS Pathog11, e1004704-e1004704. PubMed Europe PubMed DOI

2014

Aggarwal,N. and Sloane,B.F.
Cathepsin B: multiple roles in cancer
Proteomics Clin Appl8, 427-437. PubMed Europe PubMed DOI V
Arockiaraj,J., Kumaresan,V., Chaurasia,M.K., Bhatt,P., Palanisamy,R., Pasupuleti,M., Gnanam,A.J. and Kasi,M.
Molecular characterization of a novel cathepsin B from striped murrel Channa striatus: bioinformatics analysis, gene expression, synthesis of peptide and antimicrobial property
Turk J Fish Aquat Sci14, 379-389. DOI
Bengsch,F., Buck,A., Gunther,S.C., Seiz,J.R., Tacke,M., Pfeifer,D., von Elverfeldt,D., Sevenich,L., Hillebrand,L.E., Kern,U., Sameni,M., Peters,C., Sloane,B.F. and Reinheckel,T.
Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression
Oncogene33, 4474-4484. PubMed Europe PubMed DOI
Che,R., Wang,R. and Xu,T.
Comparative genomic of the teleost cathepsin B and H and involvement in bacterial induced immunity of miiuy croaker
Fish Shellfish Immunol41, 163-171. PubMed Europe PubMed DOI
Chen,T.P., Yang,S.F., Lin,C.W., Lee,H.L., Tsai,C.M. and Weng,C.J.
A4383C and C76G SNP in cathepsin B is respectively associated with the high risk and tumor size of hepatocarcinoma
Tumour Biol35, 11193-11198. PubMed Europe PubMed DOI M
Chowdhury,M.A., Moya,I.A., Bhilocha,S., McMillan,C.C., Vigliarolo,B.G., Zehbe,I. and Phenix,C.P.
Prodrug-inspired probes selective to cathepsin B over other cysteine cathepsins
J Med Chem57, 6092-6104. PubMed Europe PubMed DOI
de la Torre,C., Mondragon,L., Coll,C., Sancenon,F., Marcos,M.D., Martinez-Manez,R., Amoros,P., Perez-Paya,E. and Orzaez,M.
Cathepsin-B induced controlled release from peptide-capped mesoporous silica nanoparticles
Chemistry20, 15309-15314. PubMed Europe PubMed DOI
Edem,P.E., Czorny,S. and Valliant,J.F.
Synthesis and evaluation of radioiodinated acyloxymethyl ketones as activity-based probes for cathepsin B
J Med Chem57, 9564-9577. PubMed Europe PubMed DOI I
Hayashi,Y., Koga,Y., Zhang,X., Peters,C., Yanagawa,Y., Wu,Z., Yokoyama,T. and Nakanishi,H.
Autophagy in superficial spinal dorsal horn accelerates the cathepsin B-dependent morphine antinociceptive tolerance
Neuroscience275, 384-394. PubMed Europe PubMed DOI
Hook,G., Yu,J., Toneff,T., Kindy,M. and Hook,V.
Brain pyroglutamate amyloid-beta is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic
J Alzheimers Dis41, 129-149. PubMed Europe PubMed DOI I
Hook,G.R., Yu,J., Sipes,N., Pierschbacher,M.D., Hook,V. and Kindy,M.S.
The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury
J Neurotrauma31, 515-529. PubMed Europe PubMed DOI T I
Kim,C.J., Lee,D.I., Kim,C., Lee,K., Lee,C.H. and Ahn,I.S.
Gold Nanoparticles-Based Colorimetric Assay for Cathepsin B Activity and the Efficiency of Its Inhibitors
Anal Chem86, 3825-3833. PubMed Europe PubMed DOI A
Kisin-Finfer,E., Ferber,S., Blau,R., Satchi-Fainaro,R. and Shabat,D.
Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action
Bioorg Med Chem Lett24, 2453-2458. PubMed Europe PubMed DOI A L
Kos,J., Mitrovic,A. and Mirkovic,B.
The current stage of cathepsin B inhibitors as potential anticancer agents
Future Med Chem6, 1355-1371. PubMed Europe PubMed DOI I
Li,M., Li,Q., Yang,Z., Hu,G., Li,T., Chen,X. and Ao,J.
Identification of cathepsin B from large yellow croaker (Pseudosciaena crocea) and its role in the processing of MHC class II-associated invariant chain
Dev Comp Immunol45, 313-320. PubMed Europe PubMed DOI
Mikhaylov,G., Klimpel,D., Schaschke,N., Mikac,U., Vizovisek,M., Fonovic,M., Turk,V., Turk,B. and Vasiljeva,O.
Selective targeting of tumor and stromal cells by a nanocarrier system displaying lipidated cathepsin B inhibitor
Angew Chem Int Ed Engl53, 10077-10081. PubMed Europe PubMed DOI I
Raghav,N. and Garg,S.
SAR studies of o-hydroxychalcones and their cyclized analogs and study them as novel inhibitors of cathepsin B and cathepsin H
Eur J Pharm Sci60, 55-63. PubMed Europe PubMed DOI I
Raghav,N. and Singh,M.
SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H
Bioorg Med Chem22, 4233-4245. PubMed Europe PubMed DOI I
Raghav,N. and Singh,M.
Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H
Eur J Med Chem77, 231-242. PubMed Europe PubMed DOI I
Raghav,N. and Kaur,R.
Synthesis and evaluation of some semicarbazone- and thiosemicarbazone-based cathepsin B inhibitors
Med Chem Res23, 4669-4679. DOI I
Raghav,N. and Singh,M.
Design, synthesis and docking studies of bischalcones based quinazoline-2(1H)-ones and quinazoline-2(1H)-thiones derivatives as novel inhibitors of cathepsin B and cathepsin H
Eur J Pharm Sci54, 28-39. PubMed Europe PubMed DOI I
Ravish,I. and Raghav,N.
Curcumin as inhibitor of mammalian cathepsin B, cathepsin H, acid phosphatase and alkaline phosphatase: a correlation with pharmacological activities
Med Chem Res23, 2847-2855. DOI I
Rivera,L.E., Colon,K., Cantres-Rosario,Y.M., Zenon,F.M. and Melendez,L.M.
Macrophage derived cystatin B/cathepsin B in HIV replication and neuropathogenesis
Curr HIV Res12, 111-120. PubMed Europe PubMed DOI
Ryu,J.H., Na,J.H., Ko,H.K., You,D.G., Park,S., Jun,E., Yeom,H.J., Seo,D.H., Park,J.H., Jeong,S.Y., Kim,I.S., Kim,B.S., Kwon,I.C., Choi,K. and Kim,K.
Non-invasive optical imaging of cathepsin B with activatable fluorogenic nanoprobes in various metastatic models
Biomaterials35, 2302-2311. PubMed Europe PubMed DOI L
Shoji,A., Kabeya,M., Ishida,Y., Yanagida,A., Shibusawa,Y. and Sugawara,M.
Evaluation of cathepsin B activity for degrading collagen IV using a surface plasmon resonance method and circular dichroism spectroscopy
J Pharm Biomed Anal95, 47-53. PubMed Europe PubMed DOI
Swisher,L.Z., Prior,A.M., Shishido,S., Nguyen,T.A., Hua,D.H. and Li,J.
Quantitative electrochemical detection of cathepsin B activity in complex tissue lysates using enhanced AC voltammetry at carbon nanofiber nanoelectrode arrays
Biosens Bioelectron56, 129-136. PubMed Europe PubMed DOI A
Tan,C.D., Hobbs,C., Sameni,M., Sloane,B.F., Stutts,M.J. and Tarran,R.
Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures
J Physiol592, 5251-5268. PubMed Europe PubMed DOI
Tholen,S., Biniossek,M.L., Gansz,M., Ahrens,T.D., Schlimpert,M., Kizhakkedathu,J.N., Reinheckel,T. and Schilling,O.
Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis
Cell Mol Life Sci71, 899-916. PubMed Europe PubMed DOI K
Tong,B., Wan,B., Wei,Z., Wang,T., Zhao,P., Dou,Y., Lv,Z., Xia,Y. and Dai,Y.
Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis
Clin Exp Immunol177, 586-597. PubMed Europe PubMed DOI I
Toomey,C.B., Cauvi,D.M., Hamel,J.C., Ramirez,A.E. and Pollard,K.M.
Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity
Toxicol Sci142, 339-349. PubMed Europe PubMed DOI
van der Meer,L.T., Waanders,E., Levers,M., Venselaar,H., Roeleveld,D., Boos,J., Lanvers,C., Bruggemann,R.J., Kuiper,R.P., Hoogerbrugge,P.M., van Leeuwen,F.N. and te Loo,D.M.
A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics
Blood124, 3027-3029. PubMed Europe PubMed DOI M
Vega-Teijido,M.A., El Chamy Maluf,S., Bonturi,C.R., Sambrano,J.R. and Ventura,O.N.
Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin B by 1,2,4-thiadiazole derivatives
J Mol Model20, 2254-2254. PubMed Europe PubMed DOI I
Wei,S., Huang,Y., Huang,X., Cai,J., Yan,Y., Guo,C. and Qin,Q.
Characterization of cathepsin B gene from orange-spotted grouper, Epinephelus coioides involved in SGIV infection
Fish Shellfish Immunol36, 194-205. PubMed Europe PubMed DOI
Zhang,T., Jia,L.F., Chen,Y., Ju,C., Mo,X.J., Xu,B., Chen,S.B., Chen,J.H. and Hu,W.
[Cloning, expression and bioinformatics analysis of cathepsin B of Echinococcus granulosus]
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi26, 642-647. PubMed Europe PubMed

2013

Baek,K.H., Karki,R., Lee,E.S., Na,Y. and Kwon,Y.
Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors
Bioorg Chem51, 24-30. PubMed Europe PubMed DOI I
Balboula,A.Z., Yamanaka,K., Sakatani,M., Kawahara,M., Hegab,A.O., Zaabel,S.M. and Takahashi,M.
Cathepsin B activity has a crucial role in the developmental competence of bovine cumulus-oocyte complexes exposed to heat shock during in vitro maturation
Reproduction146, 407-417. PubMed Europe PubMed DOI I
Bao,W., Fan,Q., Luo,X., Cheng,W.W., Wang,Y.D., Li,Z.N., Chen,X.L. and Wu,D.
Silencing of cathepsin B suppresses the proliferation and invasion of endometrial cancer
Oncol Rep30, 723-730. PubMed Europe PubMed DOI K
Buhler,A., Berger,S., Bengsch,F., Martin,G., Han,H., Vierkotten,S., Pielen,A., Boehringer,D., Schlunck,G., Fauser,S., Agostini,H.T., Reinheckel,T. and Stahl,A.
Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice
Exp Eye Res115, 73-78. PubMed Europe PubMed DOI K
Dev,A., Byrne,S.M., Verma,R., Ashton-Rickardt,P.G. and Wojchowski,D.M.
Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins
J Exp Med210, 225-232. PubMed Europe PubMed DOI
Gondi,C.S. and Rao,J.S.
Cathepsin B as a cancer target
Expert Opin Ther Targets17, 281-291. PubMed Europe PubMed DOI V
Kim,C.J., Lee,D.I., Zhang,D., Lee,C.H. and Ahn,I.S.
New strategy for selective and sensitive assay of cathepsin B using a dityrosine-based material
Anal Biochem435, 166-173. PubMed Europe PubMed DOI A
Morchang,A., Panaampon,J., Suttitheptumrong,A., Yasamut,U., Noisakran,S., Yenchitsomanus,P.T. and Limjindaporn,T.
Role of cathepsin B in dengue virus-mediated apoptosis
Biochem Biophys Res Commun438, 20-25. PubMed Europe PubMed DOI
Niu,D., Jin,K., Wang,L., Sun,F. and Li,J.
Identification of cathepsin B in the razor clam Sinonovacula constricta and its role in innate immune responses
Dev Comp Immunol41, 94-99. PubMed Europe PubMed DOI
Qiu,R., Liu,X., Hu,Y.H. and Sun,B.G.
Expression characterization and activity analysis of a cathepsin B from Pacific abalone Haliotis discus hannai
Fish Shellfish Immunol34, 1376-1382. PubMed Europe PubMed DOI
Rao Malla,R., Gopinath,S., Alapati,K., Gorantla,B., Gondi,C.S. and Rao,J.S.
Knockdown of cathepsin B and uPAR inhibits CD151 and alpha3beta1 integrin-mediated cell adhesion and invasion in glioma
Mol Carcinog52, 777-790. PubMed Europe PubMed DOI K
Rothberg,J.M., Bailey,K.M., Wojtkowiak,J.W., Ben-Nun,Y., Bogyo,M., Weber,E., Moin,K., Blum,G., Mattingly,R.R., Gillies,R.J. and Sloane,B.F.
Acid-mediated tumor proteolysis: Contribution of cysteine cathepsins
Neoplasia15, 1125-1137. PubMed Europe PubMed DOI
Sosic,I., Mirkovic,B., Arenz,K., Stefane,B., Kos,J. and Gobec,S.
Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives
J Med Chem56, 521-533. PubMed Europe PubMed DOI I
Tholen,S., Biniossek,M.L., Gansz,M., Gomez-Auli,A., Bengsch,F., Noel,A., Kizhakkedathu,J.N., Boerries,M., Busch,H., Reinheckel,T. and Schilling,O.
Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome
Mol Cell Proteomics12, 611-625. PubMed Europe PubMed DOI K
Zhong,Y.J., Shao,L.H. and Li,Y.
Cathepsin B-cleavable doxorubicin prodrugs for targeted cancer therapy (Review)
Int J Oncol42, 373-383. PubMed Europe PubMed DOI

2012

Alli,A.A., Song,J.Z., Al-Khalili,O., Bao,H.F., Ma,H.P., Alli,A.A. and Eaton,D.C.
Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity
J Biol Chem287, 30073-30083. PubMed Europe PubMed DOI
Beckham,T.H., Lu,P., Cheng,J.C., Zhao,D., Turner,L.S., Zhang,X., Hoffman,S., Armeson,K.E., Liu,A., Marrison,T., Hannun,Y.A. and Liu,X.
Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B
Int J Cancer131, 2034-2043. PubMed Europe PubMed DOI
Byrne,S.M., Aucher,A., Alyahya,S., Elder,M., Olson,S.T., Davis,D.M. and Ashton-Rickardt,P.G.
Cathepsin B controls the persistence of memory CD8+ T lymphocytes
J Immunol189, 1133-1143. PubMed Europe PubMed DOI
Chen,L. and Sun,L.
Cathepsin B of Cynoglossus semilaevis: identification, expression, and activity analysis
Comp Biochem Physiol B Biochem Mol Biol161, 54-59. PubMed Europe PubMed DOI
Chen,W.N., Chen,J.Y., Jiao,B.Y., Lin,W.S., Wu,Y.L., Liu,L.L. and Lin,X.
Interaction of the hepatitis B spliced protein with cathepsin B promotes hepatoma cell migration and invasion
J Virol86, 13533-13541. PubMed Europe PubMed DOI
Chu,D.S., Johnson,R.N. and Pun,S.H.
Cathepsin B-sensitive polymers for compartment-specific degradation and nucleic acid release
J Control Release157, 445-454. PubMed Europe PubMed DOI
Colletti,G.A., Miedel,M.T., Quinn,J., Andharia,N., Weisz,O.A. and Kiselyov,K.
Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosis
J Biol Chem287, 8082-8091. PubMed Europe PubMed DOI T
Diederich,S., Sauerhering,L., Weis,M., Altmeppen,H., Schaschke,N., Reinheckel,T., Erbar,S. and Maisner,A.
Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosome-recycling compartment
J Virol86, 3736-3745. PubMed Europe PubMed DOI
Gnirss,K., Kuhl,A., Karsten,C., Glowacka,I., Bertram,S., Kaup,F., Hofmann,H. and Pohlmann,S.
Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression
Virology424, 3-10. PubMed Europe PubMed DOI
Gopinathan,A., Denicola,G.M., Frese,K.K., Cook,N., Karreth,F.A., Mayerle,J., Lerch,M.M., Reinheckel,T. and Tuveson,D.A.
Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice
Gut61, 877-884. PubMed Europe PubMed DOI
Gornicka,A., Fettig,J., Eguchi,A., Berk,M.P., Thapaliya,S., Dixon,L.J. and Feldstein,A.E.
Adipocyte hypertrophy is associated with lysosomal permeability both in vivo and in vitro: role in adipose tissue inflammation
Am J Physiol Endocrinol Metab303, E597-E606. PubMed Europe PubMed DOI
Guo,X. and Dhodapkar,K.M.
Central and overlapping role of cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells
Hum Immunol73, 871-878. PubMed Europe PubMed DOI
Ha,S.D., Park,S., Hattlmann,C.J., Barr,S.D. and Kim,S.O.
Inhibition or deficiency of cathepsin B leads defects in HIV-1 Gag pseudoparticle release in macrophages and HEK293T cells
Antiviral Res93, 175-184. PubMed Europe PubMed DOI I
Hook,V., Funkelstein,L., Wegrzyn,J., Bark,S., Kindy,M. and Hook,G.
Cysteine cathepsins in the secretory vesicle produce active peptides: cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease
Biochim Biophys Acta1824, 89-104. PubMed Europe PubMed DOI
Kindy,M.S., Yu,J., Zhu,H., El-Amouri,S.S., Hook,V. and Hook,G.R.
Deletion of the cathepsin B gene improves memory deficits in a transgenic Alzheimer's disease mouse model expressing AbetaPP containing the wild-type beta-secretase site sequence
J Alzheimers Dis29, 827-840. PubMed Europe PubMed DOI K
Kong,L. and Zhou,G.H.
Cathepsin B-RNAi-lentivirus inhibitis capillary-like tube formation in vitro
Acta Anat Sin43, 377-380. DOI K
Liang,L., Lin,S.W., Dai,W., Lu,J.K., Yang,T.Y., Xiang,Y., Zhang,Y., Li,R.T. and Zhang,Q.
Novel cathepsin B-sensitive paclitaxel conjugate: higher water solubility, better efficacy and lower toxicity
J Control Release160, 618-629. PubMed Europe PubMed DOI
Misasi,J., Chandran,K., Yang,J.Y., Considine,B., Filone,C.M., Cote,M., Sullivan,N., Fabozzi,G., Hensley,L. and Cunningham,J.
Filoviruses require endosomal cysteine proteases for entry but exhibit distinct protease preferences
J Virol86, 3284-3292. PubMed Europe PubMed DOI
Mort,J.S.
Cathepsin B
[ISSN:978-0-12-407743-0]3, 1784-1791. DOI
Orlichenko,L., Stolz,D.B., Noel,P., Behari,J., Liu,S. and Singh,V.P.
ADP-ribosylation factor 1 protein regulates trypsinogen activation via organellar trafficking of procathepsin B protein and autophagic maturation in acute pancreatitis
J Biol Chem287, 24284-24293. PubMed Europe PubMed DOI
Reinheckel,T., Peters,C., Kruger,A., Turk,B. and Vasiljeva,O.
Differential impact of cysteine cathepsins on genetic mouse models of de novo carcinogenesis: cathepsin B as emerging therapeutic target
Front Pharmacol3, 133-133. PubMed Europe PubMed DOI T
Shi,C., Zheng,D.D., Wu,F.M., Liu,J. and Xu,J.
The phosphatidyl inositol 3 kinase-glycogen synthase kinase 3beta pathway mediates bilobalide-induced reduction in amyloid beta-peptide
Neurochem Res37, 298-306. PubMed Europe PubMed DOI
Siricoon,S., Grams,S.V. and Grams,R.
Efficient inhibition of cathepsin B by a secreted type 1 cystatin of Fasciola gigantica
Mol Biochem Parasitol186, 126-133. PubMed Europe PubMed DOI
Stephens,A., Rojo,L., Araujo-Bernal,S., Garcia-Carreno,F. and Muhlia-Almazan,A.
Cathepsin B from the white shrimp Litopenaeus vannamei: cDNA sequence analysis, tissues-specific expression and biological activity
Comp Biochem Physiol B Biochem Mol Biol161, 32-40. PubMed Europe PubMed DOI
Sun,L., Wu,Z., Hayashi,Y., Peters,C., Tsuda,M., Inoue,K. and Nakanishi,H.
Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain
J Neurosci32, 11330-11342. PubMed Europe PubMed DOI
Wang,C., Sun,B., Zhou,Y., Grubb,A. and Gan,L.
Cathepsin B degrades amyloid-beta in mice expressing wild-type human amyloid precursor protein
J Biol Chem287, 39834-39841. PubMed Europe PubMed DOI
Withana,N.P., Blum,G., Sameni,M., Slaney,C., Anbalagan,A., Olive,M.B., Bidwell,B.N., Edgington,L., Wang,L., Moin,K., Sloane,B.F., Anderson,R.L., Bogyo,M.S. and Parker,B.S.
Cathepsin B inhibition limits bone metastasis in breast cancer
Cancer Res72, 1199-1209. PubMed Europe PubMed DOI I

2011

Asai,M., Yagishita,S., Iwata,N., Saido,T.C., Ishiura,S. and Maruyama,K.
An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model
FASEB J25, 3720-3730. PubMed Europe PubMed DOI I
Baudy,A.R., Sali,A., Jordan,S., Kesari,A., Johnston,H.K., Hoffman,E.P. and Nagaraju,K.
Non-invasive optical imaging of muscle pathology in mdx mice using cathepsin caged near-infrared imaging
Mol Imaging Biol13, 462-470. PubMed Europe PubMed DOI L
Biniossek,M.L., Nagler,D.K., Becker-Pauly,C. and Schilling,O.
Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S
J Proteome Res10, 5363-5373. PubMed Europe PubMed DOI P
Czibere,L., Baur,L.A., Wittmann,A., Gemmeke,K., Steiner,A., Weber,P., Putz,B., Ahmad,N., Bunck,M., Graf,C., Widner,R., Kuhne,C., Panhuysen,M., Hambsch,B., Rieder,G., Reinheckel,T., Peters,C., Holsboer,F., Landgraf,R. and Deussing,J.M.
Profiling trait anxiety: transcriptome analysis reveals cathepsin B (ctsb) as a novel candidate gene for emotionality in mice
PLoS ONE6, e23604-e23604. PubMed Europe PubMed DOI T
Dai,C., Fu,Y., Li,B., Wang,Y., Zhang,X., Wang,J. and Zhang,Q.
Linkage with cathepsin B-sensitive dipeptide promotes the in vitro and in vivo anticancer activity of PEGylated tumor necrosis factor-alpha (TNF-alpha) against murine fibrosarcoma
Sci China Life Sci54, 128-138. PubMed Europe PubMed DOI
Fustero,S., Rodrigo,V., Sanchez-Rosello,M., Del Pozo,C., Timoneda,J., Frizler,M., Sisay,M.T., Bajorath,J., Calle,L.P., Canada,F.J., Jimenez-Barbero,J. and Gutschow,M.
New cathepsin inhibitors to explore the fluorophilic properties of the S2 pocket of cathepsin B: design, synthesis, and biological evaluation
Chemistry17, 5256-5260. PubMed Europe PubMed DOI I
Girotti,M.R., Fernandez,M., Lopez,J.A., Camafeita,E., Fernandez,E.A., Albar,J.P., Benedetti,L.G., Valacco,M.P., Brekken,R.A., Podhajcer,O.L. and Llera,A.S.
SPARC promotes cathepsin B-mediated melanoma invasiveness through a collagen i/alpha2Beta1 integrin axis
J Invest Dermatol131, 2438-2447. PubMed Europe PubMed DOI
Le,Q.T., Min,H.K., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B.
Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C
J Immunol186, 7136-7143. PubMed Europe PubMed DOI
Liang,Q., Ouyang,X., Schneider,L. and Zhang,J.
Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons
Mol Neurodegener6, 37-37. PubMed Europe PubMed DOI U
Mirkovic,B., Renko,M., Turk,S., Sosic,I., Jevnikar,Z., Obermajer,N., Turk,D., Gobec,S. and Kos,J.
Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds
ChemMedChem6, 1351-1356. PubMed Europe PubMed DOI I
Murayama,S., Imae,Y., Takada,K., Kikuchi,J., Nakao,Y., Van Soest,R.W., Okada,S. and Matsunaga,S.
Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata
Bioorg Med Chem19, 6594-6598. PubMed Europe PubMed DOI I
Ryu,J.H., Kim,S.A., Koo,H., Yhee,J.Y., Lee,A., Na,J.H., Youn,I., Choi,K., Kwon,I.C., Kim,B.S. and Kim,K.
Cathepsin B-sensitive nanoprobe for in vivo tumor diagnosis
J Mater Chem21, 17631-17634. DOI L
Sako,Y., Nakaya,K. and Ito,A.
Echinococcus multilocularis: identification and functional characterization of cathepsin B-like peptidases from metacestode
Exp Parasitol127, 693-701. PubMed Europe PubMed DOI
Schechter,I. and Ziv,E.
Cathepsins S, B and L with aminopeptidases display beta-secretase activity associated with the pathogenesis of Alzheimer's disease
Biol Chem392, 555-569. PubMed Europe PubMed DOI
Sevenich,L., Werner,F., Gajda,M., Schurigt,U., Sieber,C., Muller,S., Follo,M., Peters,C. and Reinheckel,T.
Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice
Oncogene30, 54-64. PubMed Europe PubMed DOI
Sojka,D., Francischetti,I.M., Calvo,E. and Kotsyfakis,M.
Cysteine proteases from bloodfeeding arthropod ectoparasites
Adv Exp Med Biol712, 177-191. PubMed Europe PubMed DOI
Sosic,I., Mirkovic,B., Turk,S., Stefane,B., Kos,J. and Gobec,S.
Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B
Eur J Med Chem46, 4648-4656. PubMed Europe PubMed DOI I
Victor,B.C., Anbalagan,A., Mostafa Mohamed,M., Sloane,B.F. and Cavallo-Medved,D.
Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion
Breast Cancer Res13, R115-R115. PubMed Europe PubMed DOI I
Wang,X., Liu,B., Tang,B. and Xiang,J.
Potential role of cathepsin B in the embryonic and larval development of clam Meretrix meretrix
J Exp Zool B Mol Dev Evol316, 306-312. PubMed Europe PubMed DOI I
Whang,I., De Zoysa,M., Nikapitiya,C., Lee,Y., Kim,Y., Lee,S., Oh,C., Jung,S.J., Oh,M.J., Choi,C.Y., Yeo,S.Y., Kim,B.S., Kim,S.J. and Lee,J.
Molecular characterization and expression analysis of cathepsin B and L cysteine proteases from rock bream (Oplegnathus fasciatus)
Fish Shellfish Immunol30, 763-772. PubMed Europe PubMed DOI
Wisastra,R., Ghizzoni,M., Maarsingh,H., Minnaard,A.J., Haisma,H.J. and Dekker,F.J.
Isothiazolones; thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF
Org Biomol Chem9, 1817-1822. PubMed Europe PubMed DOI I
Yao,X., Zhang,J., Sun,J. and Liu,B.
Recombinant expression, characterization and expressional analysis of clam Meretrix meretrix cathepsin B, an enzyme involved in nutrient digestion
Mol Biol Rep38, 1861-1868. PubMed Europe PubMed DOI
Zhang,T., Yang,Z.Y., Bo,X.P., Wu,X.Q., Li,Z.B. and Guo,S.X.
[Cathepsin B promoted the apoptosis of vascular smooth muscle cells as induced by tumor necrosis factor-alpha]
Zhonghua Yi Xue Za Zhi91, 845-849. PubMed Europe PubMed
Zhou,Z., Wang,Y. and Bryant,S.H.
Multi-conformation 3D QSAR study of benzenesulfonyl-pyrazol-ester compounds and their analogs as cathepsin B inhibitors
J Mol Graph Model30, 135-147. PubMed Europe PubMed DOI I
Zhu,Y., Cameron,B.R., Mosi,R., Anastassov,V., Cox,J., Qin,L., Santucci,Z., Metz,M., Skerlj,R.T. and Fricker,S.P.
Inhibition of the cathepsin cysteine proteases B and K by square-planar cycloaurated gold(III) compounds and investigation of their anti-cancer activity
J Inorg Biochem105, 754-762. PubMed Europe PubMed DOI I

2010

Balboula,A.Z., Yamanaka,K., Sakatani,M., Hegab,A.O., Zaabel,S.M. and Takahashi,M.
Cathepsin B activity is related to the quality of bovine cumulus oocyte complexes and its inhibition can improve their developmental competence
Mol Reprod Dev77, 439-448. PubMed Europe PubMed DOI
Bien,S., Rimmbach,C., Neumann,H., Niessen,J., Reimer,E., Ritter,C.A., Rosskopf,D., Cinatl,J., Michaelis,M., Schroeder,H.W. and Kroemer,H.K.
Doxorubicin-induced cell death requires cathepsin B in HeLa cells
Biochem Pharmacol80, 1466-1477. PubMed Europe PubMed DOI I
Chan,A.T., Baba,Y., Shima,K., Nosho,K., Chung,D.C., Hung,K.E., Mahmood,U., Madden,K., Poss,K., Ranieri,A., Shue,D., Kucherlapati,R., Fuchs,C.S. and Ogino,S.
Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasia
Cancer Epidemiol Biomarkers Prev19, 2777-2785. PubMed Europe PubMed DOI
Costa,M.G., Batista,P.R., Shida,C.S., Robert,C.H., Bisch,P.M. and Pascutti,P.G.
How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamics
BMC Genomics11 Suppl 5, S5-S5. PubMed Europe PubMed DOI
Cunningham,E., McCarthy,E., Copley,L., Jackson,D., Johnson,D., Dalton,J.P. and Mulcahy,G.
Characterisation of cathepsin B-like cysteine protease of Lepeophtheirus salmonis
Aquaculture310, 38-42. DOI
Eykelbosh,A.J. and Van Der Kraak,G.
A role for the lysosomal protease cathepsin B in zebrafish follicular apoptosis
Comp Biochem Physiol A Mol Integr Physiol156, 218-223. PubMed Europe PubMed DOI I
Frizler,M., Stirnberg,M., Sisay,M.T. and Gutschow,M.
Development of nitrile-based peptidic inhibitors of cysteine cathepsins
Curr Top Med Chem10, 294-322. PubMed Europe PubMed DOI T I
Gross,K.W., Gomez,R.A. and Sigmund,C.D.
Twists and turns in the search for the elusive renin processing enzyme: focus on "Cathepsin B is not the processing enzyme for mouse prorenin"
Am J Physiol Regul Integr Comp Physiol298, R1209-R1211. PubMed Europe PubMed DOI
Ha,S.D., Ham,B., Mogridge,J., Saftig,P., Lin,S. and Kim,S.O.
Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm
J Biol Chem285, 2120-2129. PubMed Europe PubMed DOI
Hook,V., Hook,G. and Kindy,M.
Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease
Biol Chem391, 861-872. PubMed Europe PubMed DOI
Luo,C.L., Chen,X.P., Yang,R., Sun,Y.X., Li,Q.Q., Bao,H.J., Cao,Q.Q., Ni,H., Qin,Z.H. and Tao,L.Y.
Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway
J Neurosci Res88, 2847-2858. PubMed Europe PubMed DOI I
Matarrese,P., Ascione,B., Ciarlo,L., Vona,R., Leonetti,C., Scarsella,M., Mileo,A.M., Catricala',C., Paggi,M.G. and Malorni,W.
Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study
Mol Cancer9, 207-207. PubMed Europe PubMed DOI I
Meister,T., Niehues,R., Hahn,D., Domschke,W., Sendler,M., Lerch,M.M. and Schnekenburger,J.
Missorting of cathepsin B into the secretory compartment of CI-MPR/IGFII-deficient mice does not induce spontaneous trypsinogen activation but leads to enhanced trypsin activity during experimental pancreatitis - without affecting disease severity
J Physiol Pharmacol61, 565-575. PubMed Europe PubMed
Mercure,C., Lacombe,M.J., Khazaie,K. and Reudelhuber,T.L.
Cathepsin B is not the processing enzyme for mouse prorenin
Am J Physiol Regul Integr Comp Physiol298, R1212-R1216. PubMed Europe PubMed DOI K
Naudin,C., Lecaille,F., Chowdhury,S., Krupa,J.C., Purisima,E., Mort,J.S. and Lalmanach,G.
The occluding loop of cathepsin B prevents its effective inhibition by human kininogens
J Mol Biol400, 1022-1035. PubMed Europe PubMed DOI
Percival,M.D., Toulmond,S., Coulombe,N., Cromlish,W., Desmarais,S., Liu,S., St-Jacques,R., Gauthier,J.Y. and Fournier,J.F.
Pharmacological and genetic evidence that cathepsin B is not the physiological activator of rodent prorenin
Biol Chem391, 1469-1473. PubMed Europe PubMed DOI I
Renko,M., Pozgan,U., Majera,D. and Turk,D.
Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft
FEBS J277, 4338-4345. PubMed Europe PubMed DOI S
Sevenich,L., Schurigt,U., Sachse,K., Gajda,M., Werner,F., Muller,S., Vasiljeva,O., Schwinde,A., Klemm,N., Deussing,J., Peters,C. and Reinheckel,T.
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice
Proc Natl Acad Sci U S A107, 2497-2502. PubMed Europe PubMed DOI K
Sun,L., Wu,Z., Baba,M., Peters,C., Uchiyama,Y. and Nakanishi,H.
Cathepsin B-dependent motor neuron death after nerve injury in the adult mouse
Biochem Biophys Res Commun399, 391-395. PubMed Europe PubMed DOI
Tedelind,S., Poliakova,K., Valeta,A., Hunegnaw,R., Yemanaberhan,E.L., Heldin,N.E., Kurebayashi,J., Weber,E., Kopitar-Jerala,N., Turk,B., Bogyo,M. and Brix,K.
Nuclear cysteine cathepsin variants in thyroid carcinoma cells
Biol Chem391, 923-935. PubMed Europe PubMed DOI
Tomoo,K.
Development of cathepsin inhibitors and structure-based design of cathepsin B-specific inhibitor
Curr Top Med Chem10, 696-707. PubMed Europe PubMed DOI V I
Valadares,N.F., Dellamano,M., Soares-Costa,A., Henrique-Silva,F. and Garratt,R.C.
Molecular determinants of improved cathepsin B inhibition by new cystatins obtained by DNA shuffling
BMC Struct Biol10, 30-30. PubMed Europe PubMed DOI E
Wong,A.C., Sandesara,R.G., Mulherkar,N., Whelan,S.P. and Chandran,K.
A forward genetic strategy reveals destabilizing mutations in the ebolavirus glycoprotein that alter its protease dependence during cell entry
J Virol84, 163-175. PubMed Europe PubMed DOI
Zhou,Z., Wang,Y. and Bryant,S.H.
QSAR models for predicting cathepsin B inhibition by small molecules - continuous and binary QSAR models to classify cathepsin B inhibition activities of small molecules
J Mol Graph Model28, 714-727. PubMed Europe PubMed DOI I

2009

Bethel,P.A., Gerhardt,S., Jones,E.V., Kenny,P.W., Karoutchi,G.I., Morley,A.D., Oldham,K., Rankine,N., Augustin,M., Krapp,S., Simader,H. and Steinbacher,S.
Design of selective cathepsin inhibitors
Bioorg Med Chem Lett19, 4622-4625. PubMed Europe PubMed DOI I
Caglic,D., Kosec,G., Bojic,L., Reinheckel,T., Turk,V. and Turk,B.
Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery
Biol Chem390, 175-179. PubMed Europe PubMed DOI T
Cavallo-Medved,D., Rudy,D., Blum,G., Bogyo,M., Caglic,D. and Sloane,B.F.
Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation
Exp Cell Res315, 1234-1246. PubMed Europe PubMed DOI L
Dabydeen,S.A. and Meneses,P.I.
The role of NH4Cl and cysteine proteases in human papillomavirus type 16 infection
Virol J6, 109-109. PubMed Europe PubMed DOI
Hook,V.Y., Kindy,M., Reinheckel,T., Peters,C. and Hook,G.
Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein
Biochem Biophys Res Commun386, 284-288. PubMed Europe PubMed DOI T
Jayashankar,L., Syama Sundar,B., Awasthi,S. and Madhulika,B.
Analog based studies on cathepsin B inhibitors to design novel lead compounds for the treatment of cancer
Internet Electron J Mol Des8, 29-41. I
Jordans,S., Jenko-Kokalj,S., Kuhl,N.M., Tedelind,S., Sendt,W., Bromme,D., Turk,D. and Brix,K.
Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions
BMC Biochem10, 23-23. PubMed Europe PubMed DOI
Kim,D.E., Kim,J.Y., Schellingerhout,D., Shon,S.M., Jeong,S.W., Kim,E.J. and Kim,W.K.
Molecular imaging of cathepsin B proteolytic enzyme activity reflects the inflammatory component of atherosclerotic pathology and can quantitatively demonstrate the antiatherosclerotic therapeutic effects of atorvastatin and glucosamine
Mol Imaging8, 291-301. PubMed Europe PubMed DOI L
Lee,K.S., Kim,B.Y., Choo,Y.M., Yoon,H.J., Kang,P.D., Woo,S.D., Sohn,H.D., Roh,J.Y., Gui,Z.Z., Je,Y.H. and Jin,B.R.
Expression profile of cathepsin B in the fat body of Bombyx mori during metamorphosis
Comp Biochem Physiol B Biochem Mol Biol154, 188-194. PubMed Europe PubMed DOI
Mirkovic,B., Premzl,A., Hodnik,V., Doljak,B., Jevnikar,Z., Anderluh,G. and Kos,J.
Regulation of cathepsin B activity by 2A2 monoclonal antibody
FEBS J276, 4739-4751. PubMed Europe PubMed DOI
Pratt,M.R., Sekedat,M.D., Chiang,K.P. and Muir,T.W.
Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe
Chem Biol16, 1001-1012. PubMed Europe PubMed DOI L
Pungercar,J.R., Caglic,D., Sajid,M., Dolinar,M., Vasiljeva,O., Pozgan,U., Turk,D., Bogyo,M., Turk,V. and Turk,B.
Autocatalytic processing of procathepsin B is triggered by proenzyme activity
FEBS J276, 660-668. PubMed Europe PubMed DOI
Queiroz,A.F., Silva,R.A., Moura,R.M., Dreyfuss,J.L., Paredes-Gamero,E.J., Souza,A.C., Tersariol,I.L., Santos,E.A., Nader,H.B., Justo,G.Z. and de Sales,M.P.
Growth inhibitory activity of a novel lectin from Cliona varians against K562 human erythroleukemia cells
Cancer Chemother Pharmacol63, 1023-1033. PubMed Europe PubMed DOI
Reich,M., Wieczerzak,E., Jankowska,E., Palesch,D., Boehm,B.O. and Burster,T.
Specific cathepsin B inhibitor is cell-permeable and activates presentation of TTC in primary human dendritic cells
Immunol Lett123, 155-159. PubMed Europe PubMed DOI I
Serbielle,C., Moreau,S., Veillard,F., Voldoire,E., Bezier,A., Mannucci,M.A., Volkoff,A.N., Drezen,J.M., Lalmanach,G. and Huguet,E.
Identification of parasite-responsive cysteine proteases in Manduca sexta
Biol Chem390, 493-502. PubMed Europe PubMed DOI
Yan,B.Z., Wang,W., Chen,L.Y., Bi,M.R., Lu,Y.J., Li,B.X. and Yang,B.S.
Role of cathepsin B-mediated apoptosis in fulminant hepatic failure in mice
World J Gastroenterol15, 1231-1236. PubMed Europe PubMed DOI I
Zhang,H., Zhong,C., Shi,L., Guo,Y. and Fan,Z.
Granulysin induces cathepsin B release from lysosomes of target tumor cells to attack mitochondria through processing of Bid leading to necroptosis
J Immunol182, 6993-7000. PubMed Europe PubMed DOI
Zhou,Z., Wang,Y. and Bryant,S.H.
Computational analysis of the cathepsin B inhibitors activities through LR-MMPBSA binding affinity calculation based on docked complex
J Comput Chem30, 2165-2175. PubMed Europe PubMed DOI I

2008

Casini,A., Gabbiani,C., Sorrentino,F., Rigobello,M.P., Bindoli,A., Geldbach,T.J., Marrone,A., Re,N., Hartinger,C.G., Dyson,P.J. and Messori,L.
Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds
J Med Chem51, 6773-6781. PubMed Europe PubMed DOI I
Gunatilleke,S.S., de Oliveira,C.A., McCammon,J.A. and Barrios,A.M.
Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study
J Biol Inorg Chem13, 555-561. PubMed Europe PubMed DOI I
Gunatilleke,S.S. and Barrios,A.M.
Tuning the Au(I)-mediated inhibition of cathepsin B through ligand substitutions
J Inorg Biochem102, 555-563. PubMed Europe PubMed DOI I
Ha,S.D., Martins,A., Khazaie,K., Han,J., Chan,B.M. and Kim,S.O.
Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages
J Immunol181, 690-697. PubMed Europe PubMed
He,M., Xiao,Z., Li,S. and Chen,A.
Cathepsin B antisense oligodeoxynucleotide suppresses invasive potential of MG-63 cells
Acad J Xi'An Jiaotong Univ20, 100-103.
Hoang,V.L., Li,Y. and Kim,S.K.
Cathepsin B inhibitory activities of phthalates isolated from a marine Pseudomonas strain
Bioorg Med Chem Lett18, 2083-2088. PubMed Europe PubMed DOI I
Li,Y., Qian,Z.J. and Kim,S.K.
Cathepsin B inhibitory activities of three new phthalate derivatives isolated from seahorse, Hippocampus Kuda Bleeler
Bioorg Med Chem Lett18, 6130-6134. PubMed Europe PubMed DOI I
Liu,H., Yin,L., Zhang,N., Li,S. and Ma,C.
Isolation of cathepsin B from the muscle of silver carp (Hypophthalmichthys molitrix) and comparison of cathepsins B and L actions on surimi gel softening
Food Chem110, 310-318. PubMed Europe PubMed DOI
Myers,J., Ittiprasert,W., Raghavan,N., Miller,A. and Knight,M.
Differences in cysteine protease activity in Schistosoma mansoni-resistant and -susceptible Biomphalaria glabrata and characterization of the hepatopancreas cathepsin B full-length cDNA
J Parasitol94, 659-668. PubMed Europe PubMed DOI
Redzynia,I., Ljunggren,A., Abrahamson,M., Mort,J.S., Krupa,J.C., Jaskolski,M. and Bujacz,G.
Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B
J Biol Chem283, 22815-22825. PubMed Europe PubMed DOI
Rispe,C., Kutsukake,M., Doublet,V., Hudaverdian,S., Legeai,F., Simon,J.C., Tagu,D. and Fukatsu,T.
Large gene family expansion and variable selective pressures for cathepsin B in aphids
Mol Biol Evol25, 5-17. PubMed Europe PubMed DOI
Sakamoto,M., Miyamoto,K., Wu,Z. and Nakanishi,H.
Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat
Neurosci Lett442, 292-296. PubMed Europe PubMed DOI I
Schenker,P., Alfarano,P., Kolb,P., Caflisch,A. and Baici,A.
A double-headed cathepsin B inhibitor devoid of warhead
Protein Sci17, 2145-2155. PubMed Europe PubMed DOI I
Shao,H.L., Dong,D.J., Hu,J.D., Wang,J.X. and Zhao,X.F.
Construction of the recombinant baculovirus AcMNPV with cathepsin B-like proteinase and its insecticidal activity against Helicoverpa armigera
Pestic Biochem Physiol91, 141-146. DOI
Sun,B., Zhou,Y., Halabisky,B., Lo,I., Cho,S.H., Mueller-Steiner,S., Devidze,N., Wang,X., Grubb,A. and Gan,L.
Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease
Neuron60, 247-257. PubMed Europe PubMed DOI
Tsuji,N., Miyoshi,T., Battsetseg,B., Matsuo,T., Xuan,X. and Fujisaki,K.
A cysteine protease is critical for Babesia spp. transmission in Haemaphysalis ticks
PLoS Pathog4, e1000062-e1000062. PubMed Europe PubMed DOI
Vaananen,A.J., Salmenpera,P., Hukkanen,M., Miranda,K.M., Harjula,A., Rauhala,P. and Kankuri,E.
Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide
Free Radic Biol Med45, 749-755. PubMed Europe PubMed DOI I
Vasiljeva,O., Korovin,M., Gajda,M., Brodoefel,H., Bojic,L., Kruger,A., Schurigt,U., Sevenich,L., Turk,B., Peters,C. and Reinheckel,T.
Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice
Oncogene27, 4191-4199. PubMed Europe PubMed DOI K
Wang,G.H., Chun,L., Xia,Q.Y., Zha,X.F., Jie,C. and Liang,J.
Cathepsin B protease is required for metamorphism in silkworm, Bombyx mori
Insect Sci15, 201-208. DOI
Wang,X., Liu,B., Wang,G., Tang,B. and Xiang,J.
Molecular cloning and functional analysis of cathepsin B in nutrient metabolism during larval development in Meretrix meretrix
Aquaculture282, 41-46. DOI
Yakovlev,A.A., Gorokhovatsky,A.Y., Onufriev,M.V., Beletsky,I.P. and Gulyaeva,N.V.
Brain cathepsin B cleaves a caspase substrate
Biochemistry (Mosc)73, 332-336. PubMed Europe PubMed DOI
Zhang,F.T., Zhang,Y.B., Chen,Y.D., Zhu,R., Dong,C.W., Li,Y.Y., Zhang,Q.Y. and Gui,J.F.
Expressional induction of Paralichthys olivaceus cathepsin B gene in response to virus, poly I:C and lipopolysaccharide
Fish Shellfish Immunol25, 542-549. PubMed Europe PubMed DOI

2007

Buth,H., Luigi Buttigieg,P., Ostafe,R., Rehders,M., Dannenmann,S.R., Schaschke,N., Stark,H.J., Boukamp,P. and Brix,K.
Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes
Eur J Cell Biol86, 747-761. PubMed Europe PubMed DOI
Caglic,D., Pungercar,J.R., Pejler,G., Turk,V. and Turk,B.
Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions
J Biol Chem282, 33076-33085. PubMed Europe PubMed DOI
Fujisawa,A., Kambe,N., Saito,M., Nishikomori,R., Tanizaki,H., Kanazawa,N., Adachi,S., Heike,T., Sagara,J., Suda,T., Nakahata,T. and Miyachi,Y.
Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells
Blood109, 2903-2911. PubMed Europe PubMed DOI I
Konno,H., Kubo,K., Makabe,H., Toshiro,E., Hinoda,N., Nosaka,K. and Akaji,K.
Total synthesis of miraziridine A and identification of its major reaction site for cathepsin B
Tetrahedron63, 9502-9513. DOI I
Link,M.A., Silva,L.A. and Schaffer,P.A.
Cathepsin B mediates cleavage of herpes simplex virus type 1 origin binding protein (OBP) to yield OBPC-1, and cleavage is dependent upon viral DNA replication
J Virol81, 9175-9182. PubMed Europe PubMed DOI
Myers,M.C., Napper,A.D., Motlekar,N., Shah,P.P., Chiu,C.H., Beavers,M.P., Diamond,S.L., Huryn,D.M. and Smith,A.B., III
Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays
Bioorg Med Chem Lett17, 4761-4766. PubMed Europe PubMed DOI
Ruettger,A. and Wiederanders,B.
Microplate assay for cathepsin detection in viable cells using derivatives of 4-methoxy-beta-naphthylamide
Curr Protoc Protein SciUnit 21.21, Unit 21.21- PubMed Europe PubMed DOI A
Schmid,B., Chung,D.E., Warnecke,A., Fichtner,I. and Kratz,F.
Albumin-binding prodrugs of camptothecin and doxorubicin with an Ala-Leu-Ala-Leu-linker that are cleaved by cathepsin B: synthesis and antitumor efficacy
Bioconjug Chem18, 702-716. PubMed Europe PubMed DOI
Sitabkhan,Y. and Frankfater,A.
Differences in the expression of cathepsin B in B16 melanoma metastatic variants depend on transcription factor Sp1
DNA Cell Biol26, 673-682. PubMed Europe PubMed DOI
Stahl,S., Reinders,Y., Asan,E., Mothes,W., Conzelmann,E., Sickmann,A. and Felbor,U.
Proteomic analysis of cathepsin B- and L-deficient mouse brain lysosomes
Biochim Biophys Acta1774, 1237-1246. PubMed Europe PubMed DOI K
Weiss,F.U., Behn,C.O., Simon,P., Ruthenburger,M., Halangk,W. and Lerch,M.M.
Cathepsin B gene polymorphism Val26 is not associated with idiopathic chronic pancreatitis in European patients
Gut56, 1322-1323. PubMed Europe PubMed DOI M
Wieczerzak,E., Rodziewicz-Motowidlo,S., Jankowska,E., Gieldon,A. and Ciarkowski,J.
An enormously active and selective azapeptide inhibitor of cathepsin B
J Pept Sci13, 536-543. PubMed Europe PubMed DOI I
Yang,X.M., Hou,L.J., Wang,J.X. and Zhao,X.F.
Expression and function of cathepsin B-like proteinase in larval hemocytes of Helicoverpa armigera during metamorphosis
Arch Insect Biochem Physiol64, 164-174. PubMed Europe PubMed DOI

2006

Baici,A., Muntener,K., Willimann,A. and Zwicky,R.
Regulation of human cathepsin B by alternative mRNA splicing: homeostasis, fatal errors and cell death
Biol Chem387, 1017-1021. PubMed Europe PubMed DOI R
Baird,I.R., Mosi,R., Olsen,M., Cameron,B.R., Fricker,S.P. and Skerlj,R.T.
'3 + 1' mixed-ligand oxorhenium(V) complexes and their inhibition of the cysteine proteases cathepsin B and cathepsin K
Inorganica Chimica Acta359, 2736-2750. I
[YEAR:16-8-2006]Baran,K., Ciccone,A., Peters,C., Yagita,H., Bird,P.I., Villadangos,J.A. and Trapani,J.A.
Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells
J Biol Chem281, 30485-30491. PubMed Europe PubMed DOI
[YEAR:6-3-2006]Choe,Y., Leonetti,F., Greenbaum,D.C., Lecaille,F., Bogyo,M., Bromme,D., Ellman,J.A. and Craik,C.S.
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities
J Biol Chem281, 12824-12832. PubMed Europe PubMed DOI P
[YEAR:21-9-2006]Cole,G.M. and Frautschy,S.A.
Cat and mouse
Neuron51, 671-672. PubMed Europe PubMed DOI
Frlan,R. and Gobec,S.
Inhibitors of cathepsin B
Curr Med Chem13, 2309-2327. PubMed Europe PubMed DOI V
[YEAR:20-12-2006]Hang,H.C., Loureiro,J., Spooner,E., van der Velden,A.W., Kim,Y.M., Pollington,A.M., Maehr,R., Starnbach,M.N. and Ploegh,H.L.
Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells
ACS Chem Biol1, 713-723. PubMed Europe PubMed DOI I
Jane,D.T., Morvay,L., Dasilva,L., Cavallo-Medved,D., Sloane,B.F. and Dufresne,M.J.
Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH
Biol Chem387, 223-234. PubMed Europe PubMed DOI
Lerch,M.M. and Halangk,W.
Human pancreatitis and the role of cathepsin B
Gut55, 1228-1230. PubMed Europe PubMed DOI
[YEAR:9-3-2006]Lindkvist,B., Fajardo,I., Pejler,G. and Borgstrom,A.
Cathepsin B activates human trypsinogen 1 but not proelastase 2 or procarboxypeptidase B
Pancreatology6, 224-231. PubMed Europe PubMed DOI
Linke,M., Gordon,R.E., Brillard,M., Lecaille,F., Lalmanach,G. and Bromme,D.
Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins
Biol Chem387, 1295-1303. PubMed Europe PubMed DOI P
[YEAR:21-2-2006]Mahurkar,S., Idris,M.M., Reddy,D.N., Bhaskar,S., Rao,G.V., Thomas,V., Singh,L. and Chandak,G.R.
Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis
Gut55, 1270-1275. PubMed Europe PubMed DOI
[YEAR:24-8-2006]Mosi,R., Baird,I.R., Cox,J., Anastassov,V., Cameron,B., Skerlj,R.T. and Fricker,S.P.
Rhenium inhibitors of cathepsin B (ReO(SYS)X (where Y = S, py; X = Cl, Br, SPhOMe-p)): synthesis and mechanism of inhibition
J Med Chem49, 5262-5272. PubMed Europe PubMed DOI I
[YEAR:21-9-2006]Mueller-Steiner,S., Zhou,Y., Arai,H., Roberson,E.D., Sun,B., Chen,J., Wang,X., Yu,G., Esposito,L., Mucke,L. and Gan,L.
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease
Neuron51, 703-714. PubMed Europe PubMed DOI
[YEAR:28-11-2006]Premzl,A., Turk,V. and Kos,J.
Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro
J Cell Biochem97, 1230-1240. PubMed Europe PubMed DOI I
Ruttger,A., Mollenhauer,J., Loser,R., Gutschow,M. and Wiederanders,B.
Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-beta-naphthylamide
Biotechniques41, 469-473. PubMed Europe PubMed DOI A
[YEAR:17-2-2006]Ruzza,P., Quintieri,L., Osler,A., Calderan,A., Biondi,B., Floreani,M., Guiotto,A. and Borin,G.
Fluorescent, internally quenched, peptides for exploring the pH-dependent substrate specificity of cathepsin B
J Pept Sci12, 455-461. PubMed Europe PubMed DOI P
[YEAR:12-10-2006]Taha,T.A., El-Alwani,M., Hannun,Y.A. and Obeid,L.M.
Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease
FEBS Lett580, 6047-6054. PubMed Europe PubMed DOI P
Tan,Y., Osatomi,K. and Hara,K.
Gene structure of carp Cyprinus carpio cathepsin B
Fish Sci72, 673-678. DOI
Tan,Y., Osatomi,K., Nozaki,Y., Ishihara,T. and Hara,K.
Occurrence of two distinct molecular species of cathepsin B in carp Cyprinus carpio
Fish Sci72, 185-194.
[YEAR:1-8-2006]Watanabe,D., Yamamoto,A., Tomoo,K., Matsumoto,K., Murata,M., Kitamura,K. and Ishida,T.
Quantitative evaluation of each catalytic subsite of cathepsin B for inhibitory activity based on inhibitory activity-binding mode relationship of epoxysuccinyl inhibitors by X-ray crystal structure analyses of complexes
J Mol Biol362, 979-993. PubMed Europe PubMed DOI S I
Yang,X.M., Hou,L.J., Dong,D.J., Shao,H.L., Wang,J.X. and Zhao,X.F.
Cathepsin B-like proteinase is involved in the decomposition of the adult fat body of Helicoverpa armigera
Arch Insect Biochem Physiol62, 1-10. PubMed Europe PubMed DOI
[YEAR:5-7-2006]Zeng,G.Z., Pan,X.L., Tan,N.H., Xiong,J. and Zhang,Y.M.
Natural biflavones as novel inhibitors of cathepsin B and K
Eur J Med Chem41, 1247-1252. PubMed Europe PubMed DOI I

2005

[YEAR:7-10-2005]Baskin-Bey,E.S., Canbay,A., Bronk,S.F., Werneburg,N., Guicciardi,M.E., Nyberg,S.L. and Gores,G.J.
Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury
Am J Physiol Gastrointest Liver Physiol288, G396-G402. PubMed Europe PubMed DOI
[YEAR:4-4-2005]Bestvater,F., Dallner,C. and Spiess,E.
The C-terminal subunit of artificially truncated human cathepsin B mediates its nuclear targeting and contributes to cell viability
BMC Cell Biol6, 16-16. PubMed Europe PubMed DOI
Ellis,R.C., O'Steen,W.A., Hayes,R.L., Nick,H.S., Wang,K.K. and Anderson,D.K.
Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat
Exp Neurol193, 19-28. PubMed Europe PubMed DOI
Hook,V., Toneff,T., Bogyo,M., Greenbaum,D., Medzihradszky,K.F., Neveu,J., Lane,W., Hook,G. and Reisine,T.
Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease
Biol Chem386, 931-940. PubMed Europe PubMed DOI I
[YEAR:18-5-2005]Im,E., Venkatakrishnan,A. and Kazlauskas,A.
Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells
Mol Biol Cell16, 3488-3500. PubMed Europe PubMed DOI
Koike,M., Shibata,M., Waguri,S., Yoshimura,K., Tanida,I., Kominami,E., Gotow,T., Peters,C., von Figura,K., Mizushima,N., Saftig,P. and Uchiyama,Y.
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease)
Am J Pathol167, 1713-1728. PubMed Europe PubMed DOI K
[YEAR:25-3-2005]Muntener,K., Willimann,A., Zwicky,R., Svoboda,B., Mach,L. and Baici,A.
Folding competence of N-terminally truncated forms of human procathepsin B
J Biol Chem280, 11973-11980. PubMed Europe PubMed DOI
Rocken,C., Menard,R., Buhling,F., Vockler,S., Raynes,J., Stix,B., Kruger,S., Roessner,A. and Kahne,T.
Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation
Ann Rheum Dis64, 808-815. PubMed Europe PubMed DOI
[YEAR:1-4-2005]Wickramasinghe,N.S., Nagaraj,N.S., Vigneswaran,N. and Zacharias,W.
Cathepsin B promotes both motility and invasiveness of oral carcinoma cells
Arch Biochem Biophys436, 187-195. PubMed Europe PubMed DOI
Wieczerzak,E., Jankowska,E., Rodziewicz-Motowidlo,S., Gieldon,A., Lagiewka,J., Grzonka,Z., Abrahamson,M., Grubb,A. and Bromme,D.
Novel azapeptide inhibitors of cathepsins B and K. Structural background to increased specificity for cathepsin B
J Pept Res66 Suppl 1, 1-11. PubMed Europe PubMed DOI I
[YEAR:14-12-2005]Zhao,X.F., An,X.M., Wang,J.X., Dong,D.J., Du,X.J., Sueda,S. and Kondo,H.
Expression of the Helicoverpa cathepsin B-like proteinase during embryonic development
Arch Insect Biochem Physiol58, 39-46. PubMed Europe PubMed DOI

2004

Benchoua,A., Braudeau,J., Reis,A., Couriaud,C. and Onteniente,B.
Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemia
J Cereb Blood Flow Metab24, 1272-1279. PubMed Europe PubMed DOI
Bown,D.P., Wilkinson,H.S., Jongsma,M.A. and Gatehouse,J.A.
Characterisation of cysteine proteinases responsible for digestive proteolysis in guts of larval western corn rootworm (Diabrotica virgifera) by expression in the yeast Pichia pastoris
Insect Biochem Mol Biol34, 305-320. PubMed Europe PubMed DOI P
[YEAR:1-1-2004]Broker,L.E., Huisman,C., Span,S.W., Rodriguez,J.A., Kruyt,F.A. and Giaccone,G.
Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells
Cancer Res64, 27-30. PubMed Europe PubMed DOI
Buth,H., Wolters,B., Hartwig,B., Meier-Bornheim,R., Veith,H., Hansen,M., Sommerhoff,C.P., Schaschke,N., Machleidt,W., Fusenig,N.E., Boukamp,P. and Brix,K.
HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration
Eur J Cell Biol83, 781-795. PubMed Europe PubMed DOI
[YEAR:15-12-2004]Cotrin,S.S., Puzer,L., de Souza Judice,W.A., Juliano,L., Carmona,A.K. and Juliano,M.A.
Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B
Anal Biochem335, 244-252. PubMed Europe PubMed DOI A P
[YEAR:10-11-2004]Gan,L., Ye,S., Chu,A., Anton,K., Yi,S., Vincent,V.A., von Schack,D., Chin,D., Murray,J., Lohr,S., Patthy,L., Gonzalez-Zulueta,M., Nikolich,K. and Urfer,R.
Identification of cathepsin B as a mediator of neuronal death induced by abeta-activated microglial cells using a functional genomics approach
J Biol Chem279, 5565-5572. PubMed Europe PubMed DOI
[YEAR:20-9-2004]Gondi,C.S., Lakka,S.S., Dinh,D.H., Olivero,W.C., Gujrati,M. and Rao,J.S.
RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas
Oncogene23, 8486-8496. PubMed Europe PubMed DOI
[YEAR:25-8-2004]Lim,I.T., Meroueh,S.O., Lee,M., Heeg,M.J. and Mobashery,S.
Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis
J Am Chem Soc126, 10271-10277. PubMed Europe PubMed DOI
Mort,J.S.
Cathepsin B
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[YEAR:15-7-2004]Muntener,K., Zwicky,R., Csucs,G., Rohrer,J. and Baici,A.
Exon skipping of cathepsin B: mitochondrial targeting of a lysosomal peptidase provokes cell death
J Biol Chem279, 41012-41017. PubMed Europe PubMed DOI R
[YEAR:15-12-2004]Ravanko,K., Jarvinen,K., Helin,J., Kalkkinen,N. and Holtta,E.
Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts
Cancer Res64, 8831-8838. PubMed Europe PubMed DOI
Stachowiak,K., Tokmina,M., Karpinska,A., Sosnowska,R. and Wiczk,W.
Fluorogenic peptide substrates for carboxydipeptidase activity of cathepsin B
Acta Biochim Pol51, 81-92. PubMed Europe PubMed DOI
[YEAR:15-4-2004]Stern,I., Schaschke,N., Moroder,L. and Turk,D.
Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft
Biochem J381, 511-517. PubMed Europe PubMed DOI S I
[YEAR:4-8-2004]Yan,S. and Sloane,B.F.
Isolation of a novel USF2 isoform: repressor of cathepsin B expression
Gene337, 199-206. PubMed Europe PubMed DOI
[YEAR:19-1-2004]Yanamandra,N., Gumidyala,K.V., Waldron,K.G., Gujrati,M., Olivero,W.C., Dinh,D.H., Rao,J.S. and Mohanam,S.
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis
Oncogene23, 2224-2230. PubMed Europe PubMed DOI

2003

Aoki,H., Ahsan,M.N. and Watabe,S.
Molecular cloning and characterization of cathepsin B from the hepatopancreas of northern shrimp Pandalus borealis
Comp Biochem Physiol B Biochem Mol Biol134, 681-694. PubMed Europe PubMed DOI
Bervar,A., Zajc,I., Sever,N., Katunuma,N., Sloane,B.F. and Lah,T.T.
Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors
Biol Chem384, 447-455. PubMed Europe PubMed DOI
Canbay,A., Guicciardi,M.E., Higuchi,H., Feldstein,A., Bronk,S.F., Rydzewski,R., Taniai,M. and Gores,G.J.
Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis
J Clin Invest112, 152-159. PubMed Europe PubMed DOI I
[YEAR:15-7-2003]Eijan,A.M., Sandes,E.O., Riveros,M.D., Thompson,S., Pasik,L., Mallagrino,H., Celeste,F. and Casabe,A.R.
High expression of cathepsin B in transitional bladder carcinoma correlates with tumor invasion
Cancer98, 262-268. PubMed Europe PubMed DOI
Hentze,H., Lin,X.Y., Choi,M.S. and Porter,A.G.
Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin
Cell Death Differ10, 956-968. PubMed Europe PubMed DOI
[YEAR:15-9-2003]Houseweart,M.K., Pennacchio,L.A., Vilaythong,A., Peters,C., Noebels,J.L. and Myers,R.M.
Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1)
J Neurobiol56, 315-327. PubMed Europe PubMed DOI
Kamino,H., Hiratsuka,M., Toda,T., Nishigaki,R., Osaki,M., Ito,H., Inoue,T. and Oshimura,M.
Searching for genes involved in arteriosclerosis: proteomic analysis of cultured human umbilical vein endothelial cells undergoing replicative senescence
Cell Struct Funct28, 495-503. PubMed Europe PubMed DOI
Kikuchi,H., Yamada,T., Furuya,H., Doh-Ura,K., Ohyagi,Y., Iwaki,T. and Kira,J.
Involvement of cathepsin B in the motor neuron degeneration of amyotrophic lateral sclerosis
Acta Neuropathol (Berl)105, 462-468. PubMed Europe PubMed DOI
Muntener,K., Zwicky,R., Csucs,G. and Baici,A.
The alternative use of exons 2 and 3 in cathepsin B mRNA controls enzyme trafficking and triggers nuclear fragmentation in human cells
Histochem Cell Biol119, 93-101. PubMed Europe PubMed DOI
Podgorski,I. and Sloane,B.F.
Cathepsin B and its role(s) in cancer progression
Biochem Soc Symp2003, 263-276. PubMed Europe PubMed
[YEAR:15-2-2003]Premzl,A., Zavasnik-Bergant,V., Turk,V. and Kos,J.
Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro
Exp Cell Res283, 206-214. PubMed Europe PubMed DOI
Sentandreu,M.A., Aubry,L. and Ouali,A.
Purification of bovine cathepsin B: proteomic characterization of the different forms and production of specific antibodies
Biochem Cell Biol81, 317-326. PubMed Europe PubMed DOI
[YEAR:15-8-2003]Sweeney,D., Raymer,M.L. and Lockwood,T.D.
Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents
Biochem Pharmacol66, 663-677. PubMed Europe PubMed DOI
Yan,S. and Sloane,B.F.
Molecular regulation of human cathepsin B: implication in pathologies
Biol Chem384, 845-854. PubMed Europe PubMed DOI
Yan,S., Jane,D.T., Dufresne,M.J. and Sloane,B.F.
Transcription of cathepsin B in glioma cells: regulation by an E-box adjacent to the transcription initiation site
Biol Chem384, 1421-1427. PubMed Europe PubMed DOI
Zwicky,R., Muntener,K., Csucs,G., Goldring,M.B. and Baici,A.
Exploring the role of 5' alternative splicing and of the 3'-untranslated region of cathepsin B mRNA
Biol Chem384, 1007-1018. PubMed Europe PubMed DOI

2002

Baig,S., Damian,R.T. and Peterson,D.S.
A novel cathepsin B active site motif is shared by helminth bloodfeeders
Exp Parasitol101, 83-89. PubMed Europe PubMed DOI
Cathers,B.E., Barrett,C., Palmer,J.T. and Rydzewski,R.M.
pH Dependence of inhibitors targeting the occluding loop of cathepsin B
Bioorg Chem30, 264-275. PubMed Europe PubMed DOI I
[YEAR:15-11-2002]Cezari,M.H., Puzer,L., Juliano,M.A., Carmona,A.K. and Juliano,L.
Cathepsin B carboxydipeptidase specificity analysis using internally quenched fluorescent peptides
Biochem J368, 365-369. PubMed Europe PubMed DOI A
[YEAR:5-7-2002]Ebert,D.H., Deussing,J., Peters,C. and Dermody,T.S.
Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells
J Biol Chem277, 24609-24617. PubMed Europe PubMed DOI
[YEAR:11-6-2002]Felbor,U., Kessler,B., Mothes,W., Goebel,H.H., Ploegh,H.L., Bronson,R.T. and Olsen,B.R.
Neuronal loss and brain atrophy in mice lacking cathepsins B and L
Proc Natl Acad Sci U S A99, 7883-7888. PubMed Europe PubMed DOI K
Gray,A.W., Davies,M.E. and Jeffcott,L.B.
Localisation and activity of cathepsins K and B in equine osteoclasts
Res Vet Sci72, 95-103. PubMed Europe PubMed DOI
[YEAR:26-4-2002]Guo,M., Mathieu,P.A., Linebaugh,B., Sloane,B.F. and Reiners,J.J., Jr.
Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-beta - a process initiated by the exocytosis of cathepsin B
J Biol Chem277, 14829-14837. PubMed Europe PubMed DOI I
Jane,D.T., Dasilva,L., Koblinski,J., Horwitz,M., Sloane,B.F. and Dufresne,M.J.
Evidence for the involvement of cathepsin B in skeletal myoblast differentiation
J Cell Biochem84, 520-531. PubMed Europe PubMed DOI
[YEAR:1-2-2002]Krupa,J.C., Hasnain,S., Nagler,D.K., Menard,R. and Mort,J.S.
S2' substrate specificity and the role of His110 and His111 in the exopeptidase activity of human cathepsin B
Biochem J361, 613-619. PubMed Europe PubMed DOI
Schaschke,N., Deluca,D., Assfalg-Machleidt,I., Hohneke,C., Sommerhoff,C.P. and Machleidt,W.
Epoxysuccinyl peptide-derived cathepsin B inhibitors: modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin
Biol Chem383, 849-852. PubMed Europe PubMed DOI I
Teich,N., Bodeker,H. and Keim,V.
Cathepsin B cleavage of the trypsinogen activation peptide
BMC Gastroenterol2, 16-16. PubMed Europe PubMed DOI
Van Acker,G.J., Saluja,A.K., Bhagat,L., Singh,V.P., Song,A.M. and Steer,M.L.
Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity
Am J Physiol Gastrointest Liver Physiol283, G794-G800. PubMed Europe PubMed DOI
[YEAR:12-9-2002]Wieczerzak,E., Drabik,P., Lankiewicz,L., Oldziej,S., Grzonka,Z., Abrahamson,M., Grubb,A. and Bromme,D.
Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases
J Med Chem45, 4202-4211. PubMed Europe PubMed DOI I
[YEAR:3-6-2002]Yamamoto,A., Tomoo,K., Matsugi,K., Hara,T., In,Y., Murata,M., Kitamura,K. and Ishida,T.
Structural basis for development of cathepsin B-specific noncovalent-type inhibitor: crystal structure of cathepsin B-E64c complex
Biochim Biophys Acta1597, 244-251. PubMed Europe PubMed DOI S I
[YEAR:1-10-2002]Zwicky,R., Muntener,K., Goldring,M.B. and Baici,A.
Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes
Biochem J367, 209-217. PubMed Europe PubMed DOI

2001

[YEAR:28-5-2001]Foghsgaard,L., Wissing,D., Mauch,D., Lademann,U., Bastholm,L., Boes,M., Elling,F., Leist,M. and Jaattela,M.
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor
J Cell Biol153, 999-1010. PubMed Europe PubMed DOI
[YEAR:31-8-2001]Gray,J., Haran,M.M., Schneider,K., Vesce,S., Ray,A.M., Owen,D., White,I.R., Cutler,P. and Davis,J.B.
Evidence that inhibition of cathepsin-B contributes to the neuroprotective properties of caspase inhibitor Tyr-Val-Ala-Asp-chloromethyl ketone
J Biol Chem276, 32750-32755. PubMed Europe PubMed DOI I
[YEAR:20-12-2001]Greenspan,P.D., Clark,K.L., Tommasi,R.A., Cowen,S.D., McQuire,L.W., Farley,D.L., Van Duzer,J.H., Goldberg,R.L., Zhou,H.H., Du,Z.M., Fitt,J.J., Coppa,D.E., Fang,Z., Macchia,W., Zhu,L.J., Capparelli,M.P., Goldstein,R., Wigg,A.M., Doughty,J.R., Bohacek,R.S. and Knap,A.K.
Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design
J Med Chem44, 4524-4534. PubMed Europe PubMed DOI I
Guicciardi,M.E., Miyoshi,H., Bronk,S.F. and Gores,G.J.
Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications
Am J Pathol159, 2045-2054. PubMed Europe PubMed
Kingham,P.J. and Pocock,J.M.
Microglial secreted cathepsin B induces neuronal apoptosis
J Neurochem76, 1475-1484. PubMed Europe PubMed DOI I
[YEAR:5-5-2001]Melo,R.L., Barbosa Pozzo,R.C., Alves,L.C., Perissutti,E., Caliendo,G., Santagada,V., Juliano,L. and Juliano,M.A.
Synthesis and hydrolysis by cathepsin B of fluorogenic substrates with the general structure benzoyl-X-ARG-MCA containing non-natural basic amino acids at position X
Biochim Biophys Acta1547, 82-94. PubMed Europe PubMed DOI
[YEAR:1-6-2001]Melo,R.L., Alves,L.C., Del Nery,E., Juliano,L. and Juliano,M.A.
Synthesis and hydrolysis by cysteine and serine proteases of short internally quenched fluorogenic peptides
Anal Biochem293, 71-77. PubMed Europe PubMed DOI
Menard,R., Therrien,C., Lachance,P., Sulea,T., Qo,H., Alvarez-Hernandez,A.D. and Roush,W.R.
Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design
Biol Chem382, 839-845. PubMed Europe PubMed DOI I
[YEAR:16-3-2001]Quraishi,O. and Storer,A.C.
Identification of internal autoproteolytic cleavage sites within the prosegments of recombinant procathepsin B and procathepsin S. Contribution of a plausible unimolecular autoproteolytic event for the processing of zymogens belonging to the papain family
J Biol Chem276, 8118-8124. PubMed Europe PubMed DOI
Reinheckel,T., Deussing,J., Roth,W. and Peters,C.
Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L
Biol Chem382, 735-741. PubMed Europe PubMed DOI K
[YEAR:6-7-2001]Szilagyi,L., Kenesi,E., Katona,G., Kaslik,G., Juhasz,G. and Graf,L.
Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis
J Biol Chem276, 24574-24580. PubMed Europe PubMed DOI
[YEAR:15-4-2001]Szpaderska,A.M. and Frankfater,A.
An intracellular form of cathepsin B contributes to invasiveness in cancer
Cancer Res61, 3493-3500. PubMed Europe PubMed
[YEAR:6-3-2001]Therrien,C., Lachance,P., Sulea,T., Purisima,E.O., Qi,H., Ziomek,E., Alvarez-Hernandez,A., Roush,W.R. and Menard,R.
Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities
Biochemistry40, 2702-2711. PubMed Europe PubMed DOI I
Xu,Y. and Kawasaki,H.
Isolation and expression of cathepsin B cDNA in hemocytes during metamorphosis of Bombyx mori
Comp Biochem Physiol B Biochem Mol Biol130, 393-399. PubMed Europe PubMed DOI

2000

Del Nery,E., Alves,L.C., Melo,R.L., Cesari,M.H., Juliano,L. and Juliano,M.A.
Specificity of cathepsin B to fluorescent substrates containing benzyl side-chain-substituted amino acids at P1 subsite
J Protein Chem19, 33-38. PubMed Europe PubMed DOI P
Guicciardi,M.E., Deussing,J., Miyoshi,H., Bronk,S.F., Svingen,P.A., Peters,C., Kaufmann,S.H. and Gores,G.J.
Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
J Clin Invest106, 1127-1137. PubMed Europe PubMed DOI
Halangk,W., Lerch,M.M., Brandt-Nedelev,B., Roth,W., Ruthenbuerger,M., Reinheckel,T., Domschke,W., Lippert,H., Peters,C. and Deussing,J.
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
J Clin Invest106, 773-781. PubMed Europe PubMed DOI K
Hulkower,K.I., Butler,C.C., Linebaugh,B.E., Klaus,J.L., Keppler,D., Giranda,V.L. and Sloane,B.F.
Fluorescent microplate assay for cancer cell-associated cathepsin B
Eur J Biochem267, 4165-4170. PubMed Europe PubMed DOI A
Jacobsen,W., Christians,U. and Benet,L.Z.
In vitro evaluation of the disposition of a novel cysteine protease inhibitor
Drug Metab Dispos28, 1343-1351. PubMed Europe PubMed I
[YEAR:15-7-2000]Krupa,J.C. and Mort,J.S.
Optimization of detergents for the assay of cathepsins B, L, S, and K
Anal Biochem283, 99-103. PubMed Europe PubMed DOI A
[YEAR:28-4-2000]Mai,J., Finley,R.L., Jr., Waisman,D.M. and Sloane,B.F.
Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells
J Biol Chem275, 12806-12812. PubMed Europe PubMed DOI
Otsuka,T., Muramatsu,Y., Nakanishi,T., Hatanaka,H., Okamoto,M., Hino,M. and Hashimoto,S.
WF14865A and B, new cathepsins B and L inhibitors produced by Aphanoascus fulvescens. I. Taxonomy, production, purification and biological properties
J Antibiot (Tokyo)53, 449-458. PubMed Europe PubMed I
[YEAR:29-12-2000]Pavlova,A., Krupa,J.C., Mort,J.S., Abrahamson,M. and Bjork,I.
Cystatin inhibition of cathepsin B requires dislocation of the proteinase occluding loop. Demonstration by release of loop anchoring through mutation of His110
FEBS Lett487, 156-160. PubMed Europe PubMed DOI
[YEAR:1-4-2000]Portaro,F.C., Santos,A.B., Cezari,M.H., Juliano,M.A., Juliano,L. and Carmona,E.
Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2' and P3' variations in extended substrates
Biochem J347, 123-129. PubMed Europe PubMed DOI
Schirmeister,T. and Peric,M.
Aziridinyl peptides as inhibitors of cysteine proteases: effect of a free carboxylic acid function on inhibition
Bioorg Med Chem8, 1281-1291. PubMed Europe PubMed DOI I
[YEAR:23-6-2000]Song,J., Xu,P., Xiang,H., Su,Z., Storer,A.C. and Ni,F.
The active-site residue Cys-29 is responsible for the neutral-pH inactivation and the refolding barrier of human cathepsin B
FEBS Lett475, 157-162. PubMed Europe PubMed DOI
Yamamoto,A., Tomoo,K., Miyagawa,H., Takaoka,Y., Sumiya,S., Kitamura,K. and Ishida,T.
Molecular dynamics simulations of bovine cathepsin B and its complex with CA074
Chem Pharm Bull (Tokyo)48, 480-485. PubMed Europe PubMed I

1999

Ando,R., Sakaki,T., Morinaka,Y., Takahashi,C., Tamao,Y., Yoshii,N., Katayama,S., Saito,K.I., Tokuyama,H., Isaka,M. and Nakamura,E.
Cyclopropenone-containing cysteine proteinase inhibitors. Synthesis and enzyme inhibitory activities
Bioorg Med Chem7, 571-579. PubMed Europe PubMed I
[YEAR:22-1-1999]Jutras,I. and Reudelhuber,T.L.
Prorenin processing by cathepsin B in vitro and in transfected cells
FEBS Lett443, 48-52. PubMed Europe PubMed DOI
[YEAR:1-12-1999]Krueger,S., Haeckel,C., Buehling,F. and Roessner,A.
Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line
Cancer Res59, 6010-6014. PubMed Europe PubMed K
[YEAR:13-4-1999]Nagler,D.K., Tam,W., Storer,A.C., Krupa,J.C., Mort,J.S. and Menard,R.
Interdependency of sequence and positional specificities for cysteine proteases of the papain family
Biochemistry38, 4868-4874. PubMed Europe PubMed DOI
Otani,T. and Matsukura,A.
Cathepsin B inhibitors do not prevent the intracellular trypsinogen activation by secretagogue hyperstimulation
Pancreas19, 210-211. PubMed Europe PubMed I

1998

[YEAR:14-4-1998]Deussing,J., Roth,W., Saftig,P., Peters,C., Ploegh,H.L. and Villadangos,J.A.
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
Proc Natl Acad Sci U S A95, 4516-4521. PubMed Europe PubMed DOI K
Jones,B., Roberts,P.J., Faubion,W.A., Kominami,E. and Gores,G.J.
Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line
Am J Physiol275, G723-G730. PubMed Europe PubMed
[YEAR:23-1-1998]Nycander,M., Estrada,S., Mort,J.S., Abrahamson,M. and Bjork,I.
Two-step mechanism of inhibition of cathepsin B by cystatin C due to displacement of the proteinase occluding loop
FEBS Lett422, 61-64. PubMed Europe PubMed DOI
Peterson,J.J. and Meares,C.F.
Cathepsin substrates as cleavable peptide linkers in bioconjugates, selected from a fluorescence quench combinatorial library
Bioconjug Chem9, 618-626. PubMed Europe PubMed DOI
Steed,P.M., Lasala,D., Liebman,J., Wigg,A., Clark,K. and Knap,A.K.
Characterization of recombinant human cathepsin B expressed at high levels in baculovirus
Protein Sci7, 2033-2037. PubMed Europe PubMed DOI E
[YEAR:5-6-1998]Yu,Y., Vranken,W., Goudreau,N., de Miguel,E., Magny,M.C., Mort,J.S., Dupras,R., Storer,A.C. and Ni,F.
An NMR-based identification of peptide fragments mimicking the interactions of the cathepsin B propeptide
FEBS Lett429, 9-16. PubMed Europe PubMed DOI

1997

Gerhartz,B., Engh,R.A., Mentele,R., Eckerskorn,C., Torquato,R., Wittmann,J., Kolb,H.J., Machleidt,W., Fritz,H. and Auerswald,E.A.
Quail cystatin: isolation and characterisation of a new member of the cystatin family and its hypothetical interaction with cathepsin B
FEBS Lett412, 551-558. PubMed Europe PubMed DOI
[YEAR:10-1-1997]Illy,C., Quraishi,O., Wang,J., Purisima,E., Vernet,T. and Mort,J.S.
Role of the occluding loop in cathepsin B activity
J Biol Chem272, 1197-1202. PubMed Europe PubMed DOI
Mackay,E.A., Ehrhard,A., Moniatte,M., Guenet,C., Tardif,C., Tarnus,C., Sorokine,O., Heintzelmann,B., Nay,C., Remy,J.M., Higaki,J., Van Dorsselaer,A., Wagner,J., Danzin,C. and Mamont,P.
A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease
Eur J Biochem244, 414-425. PubMed Europe PubMed
[YEAR:14-10-1997]Nagler,D.K., Storer,A.C., Portaro,F.C., Carmona,E., Juliano,L. and Menard,R.
Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts
Biochemistry36, 12608-12615. PubMed Europe PubMed DOI
Podobnik,M., Kuhelj,R., Turk,V. and Turk,D.
Crystal structure of the wild-type human procathepsin B at 2.5 A resolution reveals the native active site of a papain-like cysteine protease zymogen
J Mol Biol271, 774-788. PubMed Europe PubMed DOI S
Spizz,G. and Blackshear,P.J.
Identification and characterization of cathepsin B as the cellular MARCKS cleaving enzyme
J Biol Chem272, 23833-23842. PubMed Europe PubMed DOI
Yamamoto,A., Hara,T., Tomoo,K., Ishida,T., Fujii,T., Hata,Y., Murata,M. and Kitamura,K.
Binding mode of CA074, a specific irreversible inhibitor, to bovine cathepsin B as determined by X-ray crystal analysis of the complex
J Biochem121, 974-977. PubMed Europe PubMed S I
Yee,S.T., Okada,Y., Ogasawara,K., Omura,S., Takatsuki,A., Kakiuchi,T., Muno,D., Kominami,E. and Mizuochi,T.
MHC class I presentation of an exogenous polypeptide antigen encoded by the murine AIDS defective virus
Microbiol Immunol41, 563-570. PubMed Europe PubMed I

1996

Bano,B., Kunapuli,S.P., Bradford,H.N. and Colman,R.W.
Structural requirements for cathepsin B and cathepsin H inhibition by kininogens
J Protein Chem15, 519-525. PubMed Europe PubMed
Chagas,J.R., Ferrer-Di Martino,M., Gauthier,F. and Lalmanach,G.
Inhibition of cathepsin B by its propeptide: use of overlapping peptides to identify a critical segment
FEBS Lett392, 233-236. PubMed Europe PubMed DOI
Chen,Y., Plouffe,C., Menard,R. and Storer,A.C.
Delineating functionally important regions and residues in the cathepsin B propeptide for inhibitory activity
FEBS Lett393, 24-26. PubMed Europe PubMed DOI
Cygler,M., Sivaraman,J., Grochulski,P., Coulombe,R., Storer,A.C. and Mort,J.S.
Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion
Structure4, 405-416. PubMed Europe PubMed S
Dehrmann,F.M., Elliott,E. and Dennison,C.
Reductive activation markedly increases the stability of cathepsins B and L to extracellular ionic conditions
Biol Chem Hoppe Seyler377, 391-394. PubMed Europe PubMed
Dunn,A.D., Myers,H.E. and Dunn,J.T.
The combined action of two thyroidal proteases releases T4 from the dominant hormone-forming site of thyroglobulin
Endocrinology137, 3279-3285. PubMed Europe PubMed DOI
Feng,M.H., Chan,S.L., Xiang,Y., Huber,C.P. and Lim,C.
The binding mode of an E-64 analog to the active site of cathepsin B
Protein Eng9, 977-986. PubMed Europe PubMed I
Li,Z., Ortega-Vilain,A.C., Patil,G.S., Chu,D.L., Foreman,J.E., Eveleth,D.D. and Powers,J.C.
Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases
J Med Chem39, 4089-4098. PubMed Europe PubMed DOI I
Salahuddin,A. and Kaur,H.
Studies on activation and inhibition of cathepsin B from buffalo liver
J Protein Chem15, 87-93. PubMed Europe PubMed DOI
Salahuddin,A., Siddiqui,F.A. and Salahuddin,P.
Isolation, purification and properties of cathepsin B from buffalo liver
Indian J Biochem Biophys33, 292-297. PubMed Europe PubMed
Sivaraman,J., Coloumbe,R., Magny,M.C., Mason,P., Mort,J.S. and Cygler,M.
Crystallization of rat procathepsin B
Acta Crystallogr D Biol Crystallogr52, 874-875. PubMed Europe PubMed DOI
Turk,D., Podobnik,M., Kuhelj,R., Dolinar,M. and Turk,V.
Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide
FEBS Lett384, 211-214. PubMed Europe PubMed DOI S

1995

Fox,T., Mason,P., Storer,A.C. and Mort,J.S.
Modification of S1 subsite specificity in the cysteine protease cathepsin B
Protein Eng8, 53-57. PubMed Europe PubMed
[YEAR:15-4-1995]Kuhelj,R., Dolinar,M., Pungercar,J. and Turk,V.
The preparation of catalytically active human cathepsin B from its precursor expressed in Escherichia coli in the form of inclusion bodies
Eur J Biochem229, 533-539. PubMed Europe PubMed
[YEAR:4-8-1995]Martichonok,V., Plouffe,C., Storer,A.C., Menard,R. and Jones,J.B.
Aziridine analogs of [[trans-(epoxysuccinyl)-L-leucyl]amino]-4-guanidinobutane (E-64) as inhibitors of cysteine proteases
J Med Chem38, 3078-3085. PubMed Europe PubMed I
Taralp,A., Kaplan,H., Sytwu,I.I., Vlattas,I., Bohacek,R., Knap,A.K., Hirama,T., Huber,C.P. and Hasnain,S.
Characterization of the S3 subsite specificity of cathepsin B
J Biol Chem270, 18036-18043. PubMed Europe PubMed DOI
Turk,D., Podobnik,M., Popovic,T., Katunuma,N., Bode,W., Huber,R. and Turk,V.
Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: a basis for the design of specific epoxysuccinyl inhibitors
Biochemistry34, 4791-4797. PubMed Europe PubMed S I
Werle,B., Ebert,W., Klein,W. and Spiess,E.
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue
Biol Chem Hoppe Seyler376, 157-164. PubMed Europe PubMed I
[YEAR:15-11-1995]Yano,T., Takahashi,N., Kurata,S. and Natori,S.
Regulation of the expression of cathepsin B in Sarcophaga peregrina (flesh fly) at the translational level during metamorphosis
Eur J Biochem234, 39-43. PubMed Europe PubMed

1994

Bromme,D., Bonneau,P.R., Lachance,P. and Storer,A.C.
Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificity
J Biol Chem269, 30238-30242. PubMed Europe PubMed
Kirschke,H. and Wiederanders,B.
Cathepsin S and related lysosomal endopeptidases
Methods Enzymol244, 500-511. PubMed Europe PubMed DOI V
Lindahl,P., Ripoll,D., Abrahamson,M., Mort,J.S. and Storer,A.C.
Evidence for the interaction of valine-10 in cystatin C with the S2 subsite of cathepsin B
Biochemistry33, 4384-4392. PubMed Europe PubMed
Mach,L., Mort,J.S. and Glossl,J.
Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme
J Biol Chem269, 13036-13040. PubMed Europe PubMed
Shinagawa,T., Nakayama,K., Uchiyama,Y., Kominami,E., Doi,Y., Hashiba,K., Yano,K., Hseu,W.A. and Murakami,K.
Role of cathepsin B as prorenin processing enzyme in human kidney
Hypertens Res18, 131-136.
[YEAR:25-2-1994]Tam,S.W., Cote-Paulino,L.R., Peak,D.A., Sheahan,K. and Murnane,M.J.
Human cathepsin B-encoding cDNAs: sequence variations in the 3'-untranslated region
Gene139, 171-176. PubMed Europe PubMed DOI
[YEAR:10-6-1994]Wagner,B.M., Smith,R.A., Coles,P.J., Copp,L.J., Ernest,M.J. and Krantz,A.
In vivo inhibition of cathepsin B by peptidyl (acyloxy)methyl ketones
J Med Chem37, 1833-1840. PubMed Europe PubMed DOI I

1993

Bihovsky,R., Powers,J.C., Kam,C.M., Walton,R. and Loewi,R.C.
Further evidence for the importance of free carboxylate in epoxysuccinate inhibitors of thiol proteases
J Enzyme Inhib7, 15-25. PubMed Europe PubMed I
Giordano,C., Calabretta,R., Gallina,C., Consalvi,V., Scandurra,R., Chiaia Noya,F. and Franchini,C.
Iodo and diiodotyrosine epoxysuccinyl derivatives as selective inhibitors of cathepsin B
Eur J Med Chem28, 917-926. I
[YEAR:5-1-1993]Hasnain,S., Hirama,T., Huber,C.P., Mason,P. and Mort,J.S.
Characterization of cathepsin B specificity by site-directed mutagenesis. Importance of Glu245 in the S2-P2 specificity for arginine and its role in transition state stabilization
J Biol Chem268, 235-240. PubMed Europe PubMed
Menard,R., Carmona,E., Plouffe,C., Bromme,D., Konishi,Y., Lefebvre,J. and Storer,A.C.
The specificity of the S1' subsite of cysteine proteases
FEBS Lett328, 107-110. PubMed Europe PubMed DOI
Mordier,S., Bechet,D., Roux,M.P., Obled,A. and Ferrara,M.
Nucleotide sequence of bovine preprocathepsin B. A study of polymorphism in the protein coding region
Biochim Biophys Acta1174, 305-311. PubMed Europe PubMed DOI M
[YEAR:15-11-1993]Takahashi,N., Kurata,S. and Natori,S.
Molecular cloning of cDNA for the 29 kDa proteinase participating in decomposition of the larval fat body during metamorphosis of Sarcophaga peregrina (flesh fly)
FEBS Lett334, 153-157. PubMed Europe PubMed DOI

1992

Ahmed,N.K., Martin,L.A., Watts,L.M., Palmer,J., Thornburg,L., Prior,J. and Esser,R.E.
Peptidyl fluoromethyl ketones as inhibitors of cathepsin B. Implication for treatment of rheumatoid arthritis
Biochem Pharmacol44, 1201-1207. PubMed Europe PubMed DOI I
Buttle,D.J., Murata,M., Knight,C.G. and Barrett,A.J.
CA074 methyl ester: a proinhibitor for intracellular cathepsin B
Arch Biochem Biophys299, 377-380. PubMed Europe PubMed DOI I
Cejudo,F.J., Murphy,G., Chinoy,C. and Baulcombe,D.C.
A gibberellin-regulated gene from wheat with sequence homology to cathepsin B of mammalian cells
Plant J2, 937-948. PubMed Europe PubMed
[YEAR:22-12-1992]Fox,T., de Miguel,E., Mort,J.S. and Storer,A.C.
Potent slow-binding inhibition of cathepsin B by its propeptide
Biochemistry31, 12571-12576. PubMed Europe PubMed DOI
[YEAR:1-3-1992]Kurata,S., Saito,H. and Natori,S.
Purification of a 29-kDa hemocyte proteinase of Sarcophaga peregrina
Eur J Biochem204, 911-914. PubMed Europe PubMed
Kurata,S., Saito,H. and Natori,S.
The 29-kDa hemocyte proteinase dissociates fat body at metamorphosis of Sarcophaga
Dev Biol153, 115-121. PubMed Europe PubMed DOI
[YEAR:1-10-1992]Ohshita,T., Nikawa,T., Towatari,T. and Katunuma,N.
Effects of selective inhibition of cathepsin B and general inhibition of cysteine proteinases on lysosomal proteolysis in rat liver in vivo and in vitro
Eur J Biochem209, 223-231. PubMed Europe PubMed DOI I
Yamamoto,A., Kaji,T., Tomoo,K., Ishida,T., Inoue,M., Murata,M. and Kitamura,K.
Crystallization and preliminary X-ray study of the cathepsin B complexed with CA074, a selective inhibitor
J Mol Biol227, 942-944. PubMed Europe PubMed DOI S I

1991

Kobayashi,H., Schmitt,M., Goretzki,L., Chucholowski,N., Calvete,J., Kramer,M., Gunzler,W.A., Janicke,F. and Graeff,H.
Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (pro-uPA)
J Biol Chem266, 5147-5152. PubMed Europe PubMed
Krantz,A., Copp,L.J., Coles,P.J., Smith,R.A. and Heard,S.B.
Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases
Biochemistry30, 4678-4687. PubMed Europe PubMed I
Murata,M., Miyashita,S., Yokoo,C., Tamai,M., Hanada,K., Hatayama,K., Towatari,T., Nikawa,T. and Katunuma,N.
Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro
FEBS Lett280, 307-310. PubMed Europe PubMed DOI I
Musil,D., Zucic,D., Turk,D., Engh,R.A., Mayr,I., Huber,R., Popovic,T., Turk,V., Towatari,T., Katunuma,N. and Bode,W.
The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity
EMBO J10, 2321-2330. PubMed Europe PubMed S
Reyes,V.E., Lu,S. and Humphreys,R.E.
Cathepsin B cleavage of Ii from class II MHC alpha- and beta-chains
J Immunol146, 3877-3880. PubMed Europe PubMed
Tchoupe,J.R., Moreau,T., Gauthier,F. and Bieth,J.G.
Photometric or fluorometric assay of cathepsin B, L and H and papain using substrates with an aminotrifluoromethylcoumarin leaving group
Biochim Biophys Acta1076, 149-151. PubMed Europe PubMed DOI A
Towatari,T., Nikawa,T., Murata,M., Yokoo,C., Tamai,M., Hanada,K. and Katunuma,N.
Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo
FEBS Lett280, 311-315. PubMed Europe PubMed DOI I

1990

Ferrara,M., Wojcik,F., Rhaissi,H., Mordier,S., Roux,M.P. and Bechet,D.
Gene structure of mouse cathepsin B
FEBS Lett273, 195-199. PubMed Europe PubMed DOI
Hu,L.Y. and Abeles,R.H.
Inhibition of cathepsin B and papain by peptidyl alpha-keto esters, alpha-keto amides, alpha-diketones, and alpha-keto acids
Arch Biochem Biophys281, 271-274. PubMed Europe PubMed DOI I
Kurata,S., Saito,H. and Natori,S.
Participation of hemocyte proteinase in dissociation of the fat body on pupation of Sarcophaga peregrina (flesh fly)
Insect Biochemistry20, 461-465.
Nguyen,Q., Mort,J.S. and Roughley,P.J.
Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B
Biochem J266, 569-573. PubMed Europe PubMed
Sloane,B.F., Moin,K., Krepela,E. and Rozhin,J.
Cathepsin B and its endogenous inhibitors: the role in tumor malignancy
Cancer Metastasis Rev9, 333-352. PubMed Europe PubMed DOI V

1989

Mason,R.W.
Interaction of lysosomal cysteine proteinases with alpha2-macroglobulin: conclusive evidence for the endopeptidase activities of cathepsins B and H
Arch Biochem Biophys273, 367-374. PubMed Europe PubMed
[YEAR:25-1-1989]Schultz,R.M., Varma-Nelson,P., Ortiz,R., Kozlowski,K.A., Orawski,A.T., Pagast,P. and Frankfater,A.
Active and inactive forms of the transition-state analog protease inhibitor leupeptin: explanation of the observed slow binding of leupeptin to cathepsin B and papain
J Biol Chem264, 1497-1507. PubMed Europe PubMed I

1988

[YEAR:1-1-1988]Baici,A., Lang,A., Horler,D. and Knopfel,M.
Cathepsin B as a marker of the dedifferentiated chondrocyte phenotype
Ann Rheum Dis47, 684-691. PubMed Europe PubMed DOI
Crawford,C., Mason,R.W., Wikstrom,P. and Shaw,E.
The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B
Biochem J253, 751-758. PubMed Europe PubMed I
Figarella,C., Miszczuk-Jamska,B. and Barrett,A.J.
Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid activation of human trypsinogen I
Biol Chem Hoppe Seyler369 Suppl, 293-298. PubMed Europe PubMed
Kirschke,H., Wikstrom,P. and Shaw,E.
Active center differences between cathepsins L and B: the S1 binding region
FEBS Lett228, 128-130. PubMed Europe PubMed
Medina,M., Leon,P. and Vallejo,C.G.
Drosophila cathepsin B-like proteinase: a suggested role in yolk degradation
Arch Biochem Biophys263, 355-363. PubMed Europe PubMed
Mort,J.S., Tam,A., Steiner,D.F. and Chan,S.J.
Expression of rat and mouse cathepsin B precursors in Escherichia coli
Biol Chem Hoppe Seyler369 Suppl, 163-167. PubMed Europe PubMed

1987

[YEAR:1-2-1987]Angliker,H., Wikstrom,P., Rauber,P. and Shaw,E.
The synthesis of lysylfluoromethanes and their properties as inhibitors of trypsin, plasmin and cathepsin B
Biochem J241, 871-875. PubMed Europe PubMed I
Bromme,D., Bescherer,K., Kirschke,H. and Fittkau,S.
Enzyme-substrate interactions in the hydrolysis of peptides by cathepsins B and H from rat liver
Biochem J245, 381-385. PubMed Europe PubMed
Polgar,L. and Csoma,C.
Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B
J Biol Chem262, 14448-14453. PubMed Europe PubMed I
Wang,X., Chan,S.J., Eddy,R.L., Byers,M.G., Fukushima,Y., Henry,W.M., Haley,L.L., Steiner,D.F. and Shows,T.B.
Chromosome assignment of cathepsin B (CTSB) to 8p22 and cathepsin H (CTSH) to 15q24-q25
Cytogenet Cell Genet46, 710-711.

1986

Chan,S.J., San Segundo,B., McCormick,M.B. and Steiner,D.F.
Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs
Proc Natl Acad Sci U S A83, 7721-7725. PubMed Europe PubMed
[YEAR:1-5-1986]Rich,D.H., Brown,M.A. and Barrett,A.J.
Purification of cathepsin B by a new form of affinity chromatography
Biochem J235, 731-734. PubMed Europe PubMed I
Takahashi,T., Dehdarani,A.H., Yonezawa,S. and Tang,J.
Porcine spleen cathepsin B is an exopeptidase
J Biol Chem261, 9375-9381. PubMed Europe PubMed

1985

Figarella,C., Amouric,M., Guy-Crotte,O. and Barrett,A.J.
Activation of human trypsinogens by cathepsin B and acidic pH
Digestion32, 176-177.
Rasnick,D.
Synthesis of peptide fluoromethyl ketones and the inhibition of human cathepsin B
Anal Biochem149, 461-465. PubMed Europe PubMed I
[YEAR:11-2-1985]Ritonja,A., Popovic,T., Turk,V., Wiedenmann,K. and Machleidt,W.
Amino acid sequence of human liver cathepsin B
FEBS Lett181, 169-172. PubMed Europe PubMed DOI
San Segundo,B., Chan,S.J. and Steiner,D.F.
Identification of cDNA clones encoding a precursor of rat liver cathepsin B
Proc Natl Acad Sci U S A82, 2320-2324. PubMed Europe PubMed

1984

Hirao,T., Hara,K. and Takahashi,K.
Purification and characterization of cathepsin B from monkey skeletal muscle
J Biochem95, 871-879. PubMed Europe PubMed
Takahashi,T., Schmidt,P.G. and Tang,J.
Novel carbohydrate structures of cathepsin B from porcine spleen
J Biol Chem259, 6059-6062. PubMed Europe PubMed
[YEAR:15-9-1984]Willenbrock,F. and Brocklehurst,K.
Natural structural variation in enzymes as a tool in the study of mechanism exemplified by a comparison of the catalytic-site structure and characteristics of cathepsin B and papain. pH-dependent kinetics of the reactions of cathepsin B from bovine spleen and from rat liver with a thiol-specific two-protonic-state probe (2,2'-dipyridyl disulphide) and with a specific synthetic substrate (N-alpha-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide)
Biochem J222, 805-814. PubMed Europe PubMed

1983

[YEAR:10-2-1983]Bajkowski,A.S. and Frankfater,A.
Steady state kinetic evidence for an acyl-enzyme intermediate in reactions catalyzed by bovine spleen cathepsin B
J Biol Chem258, 1645-1649. PubMed Europe PubMed
[YEAR:10-2-1983]Bajkowski,A.S. and Frankfater,A.
The pH dependency of bovine spleen cathepsin B-catalyzed transfer of N alpha-benzyloxycarbonyl-L-lysine from p-nitrophenol to water and dipeptide nucleophiles. Comparisons with papain
J Biol Chem258, 1650-1655. PubMed Europe PubMed
[YEAR:10-9-1983]Evans,B. and Shaw,E.
Inactivation of cathepsin B by active site-directed disulfide exchange. Application in covalent affinity chromatography
J Biol Chem258, 10227-10232. PubMed Europe PubMed
McKay,M.J., Offermann,M.K., Barrett,A.J. and Bond,J.S.
Action of human liver cathepsin B on the oxidized insulin B chain
Biochem J213, 467-471. PubMed Europe PubMed
[YEAR:15-4-1983]Shaw,E., Wikstrom,P. and Ruscica,J.
An exploration of the primary specificity site of cathepsin B
Arch Biochem Biophys222, 424-429. PubMed Europe PubMed I
Takio,K., Towatari,T., Katunuma,N., Teller,D.C. and Titani,K.
Homology of amino acid sequences of rat liver cathepsins B and H with that of papain
Proc Natl Acad Sci U S A80, 3666-3670. PubMed Europe PubMed

1982

Baici,A. and Gyger-Marazzi,M.
The slow, tight-binding inhibition of cathepsin B by leupeptin. A hysteretic effect
Eur J Biochem129, 33-41. PubMed Europe PubMed I
Barrett,A.J., Kembhavi,A.A., Brown,M.A., Kirschke,H., Knight,C.G., Tamai,M. and Hanada,K.
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L
Biochem J201, 189-198. PubMed Europe PubMed I
[YEAR:1-6-1982]Pohl,J., Baudys,M., Tomasek,V. and Kostka,V.
Identification of the active site cysteine and of the disulfide bonds in the N-terminal part of the molecule of bovine spleen cathepsin B
FEBS Lett142, 23-26. PubMed Europe PubMed
Recklies,A.D., Mort,J.S. and Poole,A.R.
Secretion of a thiol proteinase from mouse mammary carcinomas and its characterization
Cancer Res42, 1026-1032. PubMed Europe PubMed

1981

Barrett,A.J. and Kirschke,H.
Cathepsin B, cathepsin H and cathepsin L
Methods Enzymol80, 535-561. PubMed Europe PubMed DOI V
Shaw,E. and Kettner,C.
The specificity of cathepsin B
Acta Biol Med Ger40, 1503-1511. PubMed Europe PubMed

1980

Barrett,A.J.
Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates
Biochem J187, 909-912. PubMed Europe PubMed A
Bond,J.S. and Barrett,A.J.
Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. A further example of peptidyldipeptidase activity of this proteinase
Biochem J189, 17-25. PubMed Europe PubMed
Butterworth,J. and Duncan,J.J.
The hydrolysis of N-benzoyl-L-phenylalanyl-L-valyl-L-arginine- p-nitroanilide and its use as a substrate for the assay of cathepsin B
Anal Biochem106, 156-162. PubMed Europe PubMed A
[YEAR:1-9-1980]Knight,C.G.
Human cathepsin B. Application of the substrate N-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide to a study of the inhibition by leupeptin
Biochem J189, 447-453. PubMed Europe PubMed
[YEAR:17-11-1980]Takio,K., Towatari,T., Katunuma,N. and Titani,K.
Primary structure study of rat liver cathepsin B - a striking resemblance to papain
Biochem Biophys Res Commun97, 340-346. PubMed Europe PubMed

1979

Inaba,T., Hirayama,Y. and Fujinaga,N.
Inhibition of cathepsin B1 by E-64, a thiol proteinase inhibitor, and its derivatives
Agric Biol Chem43, 655-656. DOI I
Towatari,T., Kawabata,Y. and Katunuma,N.
Crystallization and properties of cathepsin B from rat liver
Eur J Biochem102, 279-289. PubMed Europe PubMed
[YEAR:28-8-1979]Watanabe,H., Green,G.D. and Shaw,E.
A comparison of the behavior of chymotrypsin and cathepsin B towards peptidyl diazomethyl ketones
Biochem Biophys Res Commun89, 1354-1360. PubMed Europe PubMed I

1978

Aronson,N.N., Jr. and Barrett,A.J.
The specificity of cathepsin B. Hydrolysis of glucagon at the C- terminus by a peptidyldipeptidase mechanism
Biochem J171, 759-765. PubMed Europe PubMed P
Towatari,T. and Katunuma,N.
Crystallization and amino acid composition of cathepsin B from rat liver lysosomes
Biochem Biophys Res Commun83, 513-520. PubMed Europe PubMed

1977

[YEAR:7-12-1977]Leary,R. and Shaw,E.
Inactivation of cathepsin B1 by diazomethyl ketones
Biochem Biophys Res Commun79, 926-931. PubMed Europe PubMed I

1976

Barrett,A.J.
An improved color reagent for use in Barrett's assay of cathepsin B
Anal Biochem76, 374-376. PubMed Europe PubMed A
[YEAR:21-6-1976]Fraki,J.E.
Human skin proteases. Separation and characterization of two acid proteases resembling cathepsin B1 and cathepsin D and of an inhibitor of cathepsin B1
Arch Dermatol Res255, 317-330. PubMed Europe PubMed

1975

Bajkowski,A.S. and Frankfater,A.
Specific spectrophotometric assays for cathepsin B1
Anal Biochem68, 119-127. PubMed Europe PubMed A
Keilova,H. and Tomasek,V.
Inhibition of cathepsin C by papain inhibitor from chicken egg white and by complex of this inhibitor with cathepsin B1
Collect Czech Chem Commun40, 218-224.
McDonald,J.K. and Ellis,S.
On the substrate specificity of cathepsins B1 and B2 including a new fluorogenic substrate for cathepsin B1
Life Sci17, 1269-1276. PubMed Europe PubMed
Otto,K. and Riesenkonig,H.
Improved purification of cathepsin B1 and cathepsin B2
Biochim Biophys Acta379, 462-475. PubMed Europe PubMed

1974

Burleigh,M.C., Barrett,A.J. and Lazarus,G.S.
Cathepsin B1. A lysosomal enzyme that degrades native collagen
Biochem J137, 387-398. PubMed Europe PubMed
Etherington,D.J.
The purification of bovine cathepsin B1 and its mode of action on bovine collagens
Biochem J137, 547-557. PubMed Europe PubMed
Keilova,H. and Tomasek,V.
Effect of papain inhibitor from chicken egg white on cathepsin B1
Biochim Biophys Acta334, 179-186.

1973

Barrett,A.J.
Human cathepsin B1. Purification and some properties of the enzyme
Biochem J131, 809-822. PubMed Europe PubMed
[YEAR:1-2-1973]Keilova,H. and Tomasek,V.
On the isozymes of cathepsin B(1)
FEBS Lett29, 335-338. PubMed Europe PubMed

1972

Barrett,A.J.
A new assay for cathepsin B1 and other thiol proteinases
Anal Biochem47, 280-293. PubMed Europe PubMed DOI A
De Lumen,B.O. and Tappel,A.L.
Continuous fluorometric assay for cathepsin B-like activity in lysosomes
Anal Biochem48, 378-385. PubMed Europe PubMed A
Iodice,A.A., Chin,J., Perker,S. and Weinstock,I.M.
Cathepsins A, B, C, D and autolysis during development of breast muscle of normal and dystrophic chickens
Arch Biochem Biophys152, 166-174. PubMed Europe PubMed

1971

Otto,K.
Cathepsins B1 and B2
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1970

[YEAR:11-12-1970]Keilova,H. and Turkova,J.
Analogy between active sites of cathepsin B1 and papain
FEBS Lett11, 287-288. PubMed Europe PubMed

1959

Greenbaum,L.M., Hirshkowitz,A. and Shoichet,I.
The activation of trypsinogen by cathepsin B
J Biol Chem234, 2885-2890. PubMed Europe PubMed

1958

Fujii,S. and Fruton,J.S.
Transamidation reactions catalyzed by cathepsins
J Biol Chem230, 1-11. PubMed Europe PubMed

1957

Greenbaum,L.M. and Fruton,J.S.
Purification and properties of beef spleen cathepsin B
J Biol Chem226, 173-180. PubMed Europe PubMed

1941

Fruton,J.S., Irving,G.W., Jr. and Bergmann,M.
On the proteolytic enzymes of animal tissues. III. The proteolytic enzymes of beef spleen, beef kidney and swine kidney. Classification of the cathepsins
J Biol Chem141, 763-774.