Literature for peptidase C01.060: cathepsin B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Li,W., Song,L., Liu,S., Zhu,J., Wu,Y. and Han,X.X. In Situ Monitoring of Cathepsin B-Induced Mitochondrial Permeabilization by Raman Spectroscopy Anal Chem (2026) PubMed Europe PubMed DOI
Qing,Y., Xu,S., Yang,D., Liu,J. and Cao,H. Thalidezine triggers Cathepsin B-mediated cell death in T-cell lymphoma by disrupting lysosomal function Chem Biol Interact (2026) 427, 111932-111932. PubMed Europe PubMed DOI K

2025

Balta,D., Varghese,A., Prieto Huarcaya,S., Di Spiezio,A., Marques,A.R.A., Akdas,E.Y., Tabakacilar,D., Drobny,A., Werner,C., Xiang,W., Machtel,R., Dobert,J.P., Fejtova,A., Richter,F., Kuspert,M., Arnold,P., Saftig,P. and Zunke,F. Recombinant cathepsins B and L promote alpha-synuclein clearance and restore lysosomal function in human and murine models with alpha-synuclein pathology Mol Neurodegener (2025) 20, 95-95. PubMed Europe PubMed DOI PMC EPMC
Bhuiya,J., Shibly,A.Z., Sheikh,A.M., Tabassum,S., Abdullah,F.B., Fahmida,J., Tamegai,H., Aritake,S., Yano,S. and Nagai,A. Deposition of aggregated cystatin C-amyloid-beta complexes and reduced cathepsin B activity modulate cerebral amyloid angiopathy pathogenesis J Neuropathol Exp Neurol (2025) PubMed Europe PubMed DOI
Bird,L.E., Xu,B., Hobbs,A.D., Ziegler,A.R., Scott,N.E., Newton,P., Thomas,D.R., Edgington-Mitchell,L.E. and Newton,H.J. Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success Nat Commun (2025) 16, 3844-3844. PubMed Europe PubMed DOI PMC EPMC
Casali,C., Gaiaschi,L., Pelloni,E., Gola,F., Cavallo,M., Milanesi,G., Ravera,M., Biggiogera,M., De Luca,F. and Bottone,M.G. Platinum(IV) anticancer therapies and cathepsin B: innovative strategies for overcoming resistance in glioblastoma cells Front Cell Dev Biol (2025) 13, 1506206-1506206. PubMed Europe PubMed DOI PMC EPMC
Chen,S., Sun,K., Peng,C., Kuang,Y., Zhang,S., Li,R., Hu,H., Liu,S., Su,F., Qiu,Q., Liang,L., Jie,L., Xiao,Y. and Xu,H. METTL1-mediated internal m(7)G methylation of cathepsin B mRNA promotes synovial aggression in rheumatoid arthritis Ann Rheum Dis (2025) PubMed Europe PubMed DOI K
Chen,W., Song,Y., Wang,L., Xiong,F. and Zhang,S. MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1 Biol Direct (2025) 20, 100-100. PubMed Europe PubMed DOI PMC EPMC
Chen,Y., Chen,Q., Ma,Y., Su,X., Zhang,C., Li,K., Liang,M., Sun,M., Zhang,L., Kuang,X., Zhang,T., Zhang,J., Yan,R., Ju,S. and Fan,W. Cathepsin B-Ignited Nanorocket To Blast Tumor Lysosomes for TLR-Fortified Lysosomal Immunotherapy with Dual-Switchable Fluorescence/Magnetic Resonance Imaging J Am Chem Soc (2025) 147, 24884-24899. PubMed Europe PubMed DOI
Enneking,A.E., Khorey,M.M. and Edgington-Mitchell,L.E. Nuclear Roles for Canonically Lysosomal Proteases Mol Cell Biol (2025) 45, 343-352. PubMed Europe PubMed DOI
Geisz-Fremy,A. Pathologically relevant trypsinogen activation in pancreatitis Am J Physiol Gastrointest Liver Physiol (2025) PubMed Europe PubMed DOI
Goto,A., Omori,K., Yamaguchi-Tomikawa,T., Kobayashi,H., Shinoda-Ito,Y., Hirai,K., Ikeda,A. and Takashiba,S. Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways Front Dent Med (2025) 6, 1547222-1547222. PubMed Europe PubMed DOI PMC EPMC
Guo,L., Li,Z., Hou,C. and Xu,J. Heat shock protein and Cathepsin B genes play important roles in cadmium stress response in whitefly Bemisia tabaci Sci Total Environ (2025) 1010, 181162-181162. PubMed Europe PubMed DOI K
Habarakadage,B., Rajendran,S., Ren,Z., Anderson,M.J., Koehne,J., Gorla,L., Morita,S., Wu,S., Hua,D.H. and Li,J. Mitigating dithiothreitol interference to gold/thiol interface in electrochemical detection of cathepsin B activity toward multiplex protease analysis Biosens Bioelectron (2025) 273, 117193-117193. PubMed Europe PubMed DOI PMC EPMC
Hook,V., Podvin,S., Yoon,M.C., Phan,V.V., Florio,J., Spencer,B., Mosier,C., Cheng,A., Ahuett,S., Almaliti,J., Gerwick,W.H., Rissman,R.A. and O'Donoghue,A.J. Neutral pH-Selective Inhibition of Cytosolic Cathepsin B: A Novel Drug Targeting Strategy for Traumatic Brain Injury and Alzheimer's Disease ACS Chem Biol (2025) PubMed Europe PubMed DOI
Hossain,S., Bin Manjur,O.H., Shimu,M.S.S., Sultana,T., Naim,M.R., Siddique,S., Al Mamun,A., Rahman,M.M., Saleh,M.A., Hasan,M.R. and Rahman,T. In silico evaluation of missense SNPs in cancer-associated Cystatin A protein and their potential to disrupt Cathepsin B interaction Heliyon (2025) 11, e42478-e42478. PubMed Europe PubMed DOI PMC EPMC
Jia,H., Zhang,B., Han,X., Yu,P., Xiong,B., Liu,T., Shan,L., Yang,X. and Hou,Q. Inhibition of Cathepsin B Ameliorates Murine Cognitive Dysfunction and Neuronal Damage in Ischemic Stroke by Inhibiting Mitochondrial Apoptosis and Drp1-Mediated Mitochondrial Fission Mol Neurobiol (2025) PubMed Europe PubMed DOI
Kelley,C., Guarin,J.R., Henrich,E., Fatherree,J.P., Dunn,C.M., Yui,A. and Oudin,M.J. Cell-line specific role of Cathepsin B in triple-negative breast cancer growth, invasion and response to chemotherapy bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC
Liang,T., Zhang,Z., Xu,L., Sun,Z. and Xu,W. Cathepsin B hyperactivation facilitates exosome release of CVB3 particles and exacerbation of acute pancreatitis by impairing lysosomal integrity and acidification MBio (2025) , e0311125-e0311125. PubMed Europe PubMed DOI
Lin,H., Nie,L., Wu,D., Zhang,D., Peng,R., Tao,S., Ye,Z., Zhu,S., Ye,M. and Xiao,J. Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia Commun Biol (2025) 8, 845-845. PubMed Europe PubMed DOI PMC EPMC
Liu,H., Xu,L., Wang,T., Liu,Y., Pan,J., Xiong,W., Zheng,F., Wang,Y. and Sun,S. Cathepsin B-induced cascade DNA-AuNP nanomachine for activated tumor theranostics Talanta (2025) 293, 128103-128103. PubMed Europe PubMed DOI
Lu,Z., Zhang,Y., Zhong,Y., Qiang,L., Ge,P., Lei,Z., Zhao,M., Fang,Y., Li,B., Wang,J., Chai,Q. and Liu,C.H. A bacterial effector manipulates host lysosomal protease activity-dependent plasticity in cell death modalities to facilitate infection Proc Natl Acad Sci U S A (2025) 122, e2406715122-e2406715122. PubMed Europe PubMed DOI
Modenbach,J.M., Moller,C., Asgarbeik,S., Geist,N., Rimkus,N., Dorr,M., Wolfgramm,H., Steil,L., Susemihl,A., Graf,L., Schmoker,O., Bottcher,D., Hammer,E., Glaubitz,J., Lammers,M., Delcea,M., Volker,U., Aghdassi,A.A., Lerch,M.M., Weiss,F.U., Bornscheuer,U.T. and Sendler,M. Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis Nat Commun (2025) 16, 1702-1702. PubMed Europe PubMed DOI PMC EPMC
Ntemafack,A., Dzelamonyuy,A., Nchinda,G. and Bopda Waffo,A. Mapping Immunological, Host Receptor Binding Determinants, and Cathepsin Cleavage Site of EBOV Glycoprotein Utilizing the Qubevirus Platform ACS Omega (2025) 10, 14283-14295. PubMed Europe PubMed DOI PMC EPMC
Pinto,A., Haytural,H., Loss,C., Alvarez,C., Ertas,A., Curtis,O., Williams,A.R., Murphy,G., Salleng,K., Gografe,S., Altintas,A., Kafri,T., Barres,R., Deshmukh,A.S. and van Praag,H. Muscle Cathepsin B treatment improves behavioral and neurogenic deficits in a mouse model of Alzheimer's Disease bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC
Podvin,S., Florio,J., Spencer,B., Mante,M., Guzman,E., Arias,C., Mosier,C., Phan,V.V., Yoon,M.C., Almaliti,J., O'Donoghue,A.J., Gerwick,W.H., Rissman,R.A. and Hook,V. Activation of Cytosolic Cathepsin B Activity in the Brain by Traumatic Brain Injury and Inhibition by the Neutral pH Selective Inhibitor Probe Z-Arg-Lys-AOMK ACS Chem Neurosci (2025) 16, 1297-1308. PubMed Europe PubMed DOI PMC EPMC
Porzberg,M.R.B., Groenewold,G.J.M., Lyoo,H., Jakob,A.K.M.H., Titulaer,W.H.C., Cavina,L., Poelaert,K.C.K., Zwaagstra,M., Dieteren,C.E.J., Lemmers,J.G.H., Hamdani,S.H., van Buuren,B.N.M., Ackerschott,B., Platteeuw,J., Michorius,J., Martina,B.E.E., Feiters,M.C., Girones,D., van Kuppeveld,F.J.M., van Hemert,M.J. and Rutjes,F.P.J.T. Peptidomimetic Phenoxymethyl Ketone Warheads as Potent Dual-Mode Inhibitors against SARS-CoV-2 M(pro) and Cathepsin J Med Chem (2025) PubMed Europe PubMed DOI I
Pytelkova,J., Orsaghova,K., Benova,M., Horn,M., Schabussova,I. and Mares,M. Allergenic mites excrete cathepsins B and C as active cysteine proteases distinct from group 1 allergens Int J Biol Macromol (2025) 331, 148383-148383. PubMed Europe PubMed DOI
Syrocheva,A.O., Ivanov,K.I., Laktyushkin,V.S., Gorokhovets,N.V., Parodi,A. and Zamyatnin,A.A., Jr. Expression Interplay Between Cathepsin B and Its Natural Inhibitor Stefin A in Cancer and Embryonic Cell Lines Cell Biol Int (2025) PubMed Europe PubMed DOI
Syrocheva,A.O., Kolesova,E.P., Parodi,A. and Zamyatnin,A.A., Jr. Stefin A Regulation of Cathepsin B Expression and Localization in Cancerous and Non-Cancerous Cells Int J Mol Sci (2025) 26 PubMed Europe PubMed DOI PMC EPMC
Tang,C., Wang,J., Ge,M., Fu,L., Huang,J., Yadav,H., Shi,J., Feng,S. and Wu,F. DSS-induced colitis exacerbates Alzheimer's pathology via neutrophil elastase and cathepsin B activation Int Immunopharmacol (2025) 155, 114666-114666. PubMed Europe PubMed DOI
Wu,Y., Cleverley,K. and Wiseman,F.K. Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy 21 human cellular and mouse models PLoS ONE (2025) 20, e0316822-e0316822. PubMed Europe PubMed DOI PMC EPMC
Xie,Z., Yang,Q., Lan,F., Kong,W., Zhao,S., Sun,J., Yan,Y., Quan,Z., Bai,Z., Qing,H., Mao,J. and Ni,J. Cathepsin B deficiency disrupts cortical development via PEG3, leading to depression-like behavior Commun Biol (2025) 8, 1097-1097. PubMed Europe PubMed DOI PMC EPMC K
Xu,M., Zhang,W., Xiong,Y., Fu,H., Qiao,H., Jiang,S. and Jin,S. Identification of Potential Roles of Cathepsin B-like in the Response to Alkali Treatment in Macrobrachium nipponense Int J Mol Sci (2025) 26 PubMed Europe PubMed DOI PMC EPMC
Yang,X., Cea-Medina,P., Gopalswamy,M., Vaidya,A., Schavier,S., Oltzen,S., Mossner,S., Huang,A., Qi,J., Holken,J.M., Teusch,N., Floss,D.M., Uhrberg,M., Gohlke,H. and Scheu,S. The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B Protein Sci (2025) 34, e70173-e70173. PubMed Europe PubMed DOI PMC EPMC I
Yu,Q., Xu,D., Chen,S., Yu,Y., Yu,H., Li,Y., Sun,W. and Yin,S. Cathepsin B Activatable Fluorescent Probe for Antitumor Efficiency Feedback: Attempt To Detect Certain Apoptotic Cells Anal Chem (2025) PubMed Europe PubMed DOI
Zhang,J.S., Meng,J.Y., Yang,L. and Zhang,C.Y. Identification and expression analysis of cathepsin B genes in Myzus persicae (Hemiptera: Aphididae) and their response to environmental stresses Bull Entomol Res (2025) , 1-11. PubMed Europe PubMed DOI
Zhang,Q., Liu,Y., Zhang,J., Dong,H., Pan,X. and Zhang,J. Development and Mechanistic Evaluation of Cathepsin B-Activatable Peptide-Drug Conjugate PROTACs for Targeted Protein Degradation in Malignant Tumors: Advancing Precision Protein Degradation Therapeutics in Oncology Small (2025) , e06562-e06562. PubMed Europe PubMed DOI
Zhang,S., Zhu,H., Li,G. and Zhu,M. Cathepsin B promotes optic nerve axonal regeneration Neuroreport (2025) 36, 279-289. PubMed Europe PubMed DOI PMC EPMC
Zhao,Q., Li,H., Liu,D., Zhou,B., Gong,C., Chen,L. and Liao,F. The SGLT2 inhibitor dapagliflozin suppresses endothelial cell pyroptosis mediated by the NF-kappaB/NLRP3 pathway through downregulation of CTSB Biochem Pharmacol (2025) 236, 116857-116857. PubMed Europe PubMed DOI
Zhao,Y., Zhuang,Y., Shi,J., Fan,H., Lv,Q. and Guo,X. Cathepsin B induces kidney diseases through different types of programmed cell death Front Immunol (2025) 16, 1535313-1535313. PubMed Europe PubMed DOI PMC EPMC V
Zhuang,X., Li,X., Li,W., Xu,X., Lin,F., Liu,Y., Chen,C., Zhang,X., Zhang,P., Li,C. and Fu,Q. Identification, Expression Profiling, Microbial Binding, and Agglutination Analyses of Two Cathepsin B Genes in Black Rockfish (Sebastes schlegelii) Mar Drugs (2025) 23 PubMed Europe PubMed DOI PMC EPMC

2024

Bernardim,B., Conde,J., Hakala,T., Becher,J.B., Canzano,M., Vasco,A.V., Knowles,T.P.J., Cameron,J. and Bernardes,G.J.L. Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin-Drug Conjugates Bioconjug Chem (2024) 35, 132-139. PubMed Europe PubMed DOI PMC EPMC
Cai,Z., Xu,S. and Liu,C. Cathepsin B in cardiovascular disease: Underlying mechanisms and therapeutic strategies J Cell Mol Med (2024) 28, e70064-e70064. PubMed Europe PubMed DOI PMC EPMC V
Cao,F., Tang,C., Chen,X., Tu,Z., Jin,Y., Turk,O.M., Nishimura,R.N., Ebens,A., Dubljevic,V., Campbell,J.A., Zhou,J. and Hansen,J.E. Cathepsin B Nuclear Flux in a DNA-Guided "Antinuclear Missile" Cancer Therapy ACS Cent Sci (2024) 10, 1562-1572. PubMed Europe PubMed DOI PMC EPMC
Dai,Q., Xie,L., Ren,E. and Liu,G. Cathepsin B Responsive Peptide-Purpurin Conjugates Assembly-Initiated in Situ Self-Aggregation for Cancer Sonotheranostics Nano Lett (2024) 24, 950-957. PubMed Europe PubMed DOI
Deng,Y., Yan,K., Xu,L., Liu,X., Zhao,F., Wang,S., Zhang,F., Liang,G. and Wang,R. "Turn-on" NIR-II fluorescence of a dually quenched probe for sensitive imaging of cathepsin B in vivo Chem Commun (Camb) (2024) PubMed Europe PubMed DOI
Dietze,K.A., Nguyen,K., Pathni,A., Fazekas,F., Baker,J.M., Gebru,E., Wang,A., Sun,W., Rosati,E., Lum,D., Rapoport,A.P., Fan,X., Atanackovic,D., Upadhayaya,A. and Luetkens,T. Cathepsin B causes trogocytosis-mediated CAR T cell dysfunction bioRxiv (2024) PubMed Europe PubMed DOI PMC EPMC
Gallwitz,L., Bleibaum,F., Voss,M., Schweizer,M., Spengler,K., Winter,D., Zophel,F., Muller,S., Lichtenthaler,S., Damme,M. and Saftig,P. Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis Cell Mol Life Sci (2024) 81, 227-227. PubMed Europe PubMed DOI PMC EPMC
Geri,A., Massai,L., Novinec,M., Turel,I. and Messori,L. Reactions of Medicinal Gold Compounds with Cathepsin B Explored through Electrospray Mass Spectrometry Measurements Chempluschem (2024) 89, e202300321-e202300321. PubMed Europe PubMed DOI
Jangra,S., Raghav,N., Wadhwa,D., Kumar,A., Bhattacharyya,S., Kumar,V. and Sheokand,J. Biological evaluation of trans-2,3-dihydrofuro[3,2-c]coumarins as potential cathepsin inhibitors and anticancer agents J Biomater Sci Polym Ed (2024) , 1-19. PubMed Europe PubMed DOI I
Jiang,M., Ge,Z., Yin,S., Liu,Y., Gao,H., Lu,L., Wang,H., Li,C., Ni,J., Pan,Y. and Lin,L. Cathepsin B Modulates Alzheimer's Disease Pathology Through SAPK/JNK Signals Following Administration of Porphyromonas gingivalis-Derived Outer Membrane Vesicles J Clin Periodontol (2024) PubMed Europe PubMed DOI
Jinda,H., Nakashima,K., Watanabe,H. and Ono,M. Synthesis and Evaluation of a Cathepsin B-Recognizing Trifunctional Chelating Agent to Improve Tumor Retention of Radioimmunoconjugates J Labelled Comp Radiopharm (2024) 67, 295-304. PubMed Europe PubMed DOI
Jones-Tabah,J., He,K., Karpilovsky,N., Senkevich,K., Deyab,G., Pietrantonio,I., Goiran,T., Cousineau,Y., Nikanorova,D., Goldsmith,T., Del Cid Pellitero,E., Chen,C.X., Luo,W., You,Z., Abdian,N., Ahmad,J., Ruskey,J.A., Asayesh,F., Spiegelman,D., Fahn,S., Waters,C., Monchi,O., Dauvilliers,Y., Dupre,N., Miliukhina,I., Timofeeva,A., Emelyanov,A., Pchelina,S., Greenbaum,L., Hassin-Baer,S., Alcalay,R.N., Milnerwood,A., Durcan,T.M., Gan-Or,Z. and Fon,E.A. Correction: The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons Mol Neurodegener (2024) 19, 94-94. PubMed Europe PubMed DOI PMC EPMC
Jones-Tabah,J., He,K., Karpilovsky,N., Senkevich,K., Deyab,G., Pietrantonio,I., Goiran,T., Cousineau,Y., Nikanorova,D., Goldsmith,T., Del Cid Pellitero,E., Chen,C.X., Luo,W., You,Z., Abdian,N., Ahmad,J., Ruskey,J.A., Asayesh,F., Spiegelman,D., Fahn,S., Waters,C., Monchi,O., Dauvilliers,Y., Dupre,N., Miliukhina,I., Timofeeva,A., Emelyanov,A., Pchelina,S., Greenbaum,L., Hassin-Baer,S., Alcalay,R.N., Milnerwood,A., Durcan,T.M., Gan-Or,Z. and Fon,E.A. The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons Mol Neurodegener (2024) 19, 88-88. PubMed Europe PubMed DOI PMC EPMC
Kumar,A., Rani,M., Giovannuzzi,S., Raghav,N., Supuran,C.T. and Sharma,P.K. Novel thiazolotriazole and triazolothiadiazine scaffolds as selective tumor associated carbonic anhydrase inhibitors endowed with cathepsin B inhibition Arch Pharm (Weinheim) (2024) , e2400366-e2400366. PubMed Europe PubMed DOI I
Li,H., Liang,B., Gao,X., Peng,Y., Liu,Q., Qiu,L. and Lin,J. Cathepsin B-Activated PET Tracer for In Vivo Tumor Imaging Mol Pharm (2024) 21, 1382-1389. PubMed Europe PubMed DOI
Li,H., Li,Y., Li,K., Wang,Q., Yang,J., Qiu,L. and Lin,J. Positron Emission Tomography Imaging of Cathepsin B in Tumors with Activable Small Molecule Tracers J Med Chem (2024) PubMed Europe PubMed DOI
Li,M.Y., Wu,Y., Tang,H.L., Wang,Y., Li,B., He,Y.Y., Yan,G.J. and Yang,Z.M. Embryo-Derived Cathepsin B Promotes Implantation and Decidualization by Activating Pyroptosis Adv Sci (Weinh) (2024) , e2402299-e2402299. PubMed Europe PubMed DOI
Liu,F., Zhou,T., Zhang,S., Li,Y., Chen,Y., Miao,Z., Wang,X., Yang,G., Li,Q., Zhang,L. and Liu,Y. Cathepsin B: The dawn of tumor therapy Eur J Med Chem (2024) 269, 116329-116329. PubMed Europe PubMed DOI
Lundin,B., Comby,A.C., Berezovska,O. and Maesako,M. Negative Regulation of Cathepsins by beta-Amyloid eNeuro (2024) 11 PubMed Europe PubMed DOI PMC EPMC
Mancano,A.S.F., Pina,J.G., Froes,B.R. and Sciani,J.M. Autophagy-lysosomal pathway impairment and cathepsin dysregulation in Alzheimer's disease Front Mol Biosci (2024) 11, 1490275-1490275. PubMed Europe PubMed DOI PMC EPMC V
Moller,C., Rimkus,N., Skala,F.F.O., Merouze,M., Bottcher,D., Dorr,M. and Bornscheuer,U.T. Improved recombinant expression of soluble cathepsin B and L in Escherichia coli Appl Microbiol Biotechnol (2024) 108, 536-536. PubMed Europe PubMed DOI PMC EPMC
Monika,M., Chander,C., Kaur,P., Raghav,N., Sharma,P.K. and Ram,S. Synthesis, Biological Evaluation, and Computational Studies of Schiff's Base Derivatives of 4-(4-Amino-5-mercapto-4H-1,2,4-triazol-3-yl)benzenesulfonamide as Cathepsin B Inhibitors Chem Biodivers (2024) , e202402575-e202402575. PubMed Europe PubMed DOI
Nandhini,M., Pitchumani Violet Mary,C., Gopinath,S. and Vijayakumar,S. Structure based interaction and molecular dynamics studies of cysteine protease Cathepsin B against curcumin and resveratrol J Biomol Struct Dyn (2024) , 1-11. PubMed Europe PubMed DOI I
Norton,E.S., Whaley,L.A., Jones,V.K., Brooks,M.M., Russo,M.N., Morderer,D., Jessen,E., Schiapparelli,P., Ramos-Fresnedo,A., Zarco,N., Carrano,A., Rossoll,W., Asmann,Y.W., Lam,T.T., Chaichana,K.L., Anastasiadis,P.Z., Quinones-Hinojosa,A. and Guerrero-Cazares,H. Cell-specific cross-talk proteomics reveals cathepsin B signaling as a driver of glioblastoma malignancy near the subventricular zone Sci Adv (2024) 10, eadn1607-eadn1607. PubMed Europe PubMed DOI PMC EPMC K
Sagar,S., Gadkari,P., Hiwale,K.M., Jagtap,M.M. and Naseri,S. Role of Cathepsin B Expression in Oral Squamous Cell Carcinoma: A Comprehensive Review Cureus (2024) 16, e54267-e54267. PubMed Europe PubMed DOI PMC EPMC V
Siddiqui,A.A., Merquiol,E., Bruck-Haimson,R., Hirbawi,J., Boocholez,H., Cohen,I., Yan,Y., Dong,M.Q., Blum,G. and Cohen,E. Cathepsin B promotes Abeta proteotoxicity by modulating aging regulating mechanisms Nat Commun (2024) 15, 8564-8564. PubMed Europe PubMed DOI PMC EPMC K
Siwach,K., Arya,P., Vats,L., Sharma,V., Giovannuzzi,S., Raghav,N., Supuran,C.T. and Sharma,P.K. Benzenesulfonamides functionalized with triazolyl-linked pyrazoles possess dual cathepsin B and carbonic anhydrase inhibitory action Arch Pharm (Weinheim) (2024) , e2400114-e2400114. PubMed Europe PubMed DOI I
Siwach,K., Rani,M., Vats,L., Giovannuzzi,S., Paul,A.K., Brahma,M., Kumari,N., Maruthi,M., Raghav,N., Supuran,C.T. and Sharma,P.K. 1,2,3-Triazole-based esters and carboxylic acids as nonclassical carbonic anhydrase inhibitors capable of cathepsin B inhibition Arch Pharm (Weinheim) (2024) 357, e2300372-e2300372. PubMed Europe PubMed DOI I
Stuart,S., Tarade,D. and Ohh,M. Cathepsins L and B target HIF1alpha for oxygen-independent proteolytic cleavage Sci Rep (2024) 14, 14799-14799. PubMed Europe PubMed DOI PMC EPMC
Vashisth,C., Kaushik,T., Vashisth,N. and Raghav,N. Cinnamaldehyde hydrazone derivatives as potential cathepsin B inhibitors: parallel in-vitro investigation in liver and cerebrospinal fluid Int J Biol Macromol (2024) 272, 132684-132684. PubMed Europe PubMed DOI I
Vashisth,C., Verma,N.K., Afshari,M., Bendi,A. and Raghav,N. In silico and in vitro validation of cinnamaldehyde as a potential cathepsin B inhibitor Chem Biodivers (2024) , e202401985-e202401985. PubMed Europe PubMed DOI I
Wang,D., Wang,T., Kim,D., Tan,S., Liu,S., Wan,J. and Deng,Q. MicroRNA-375 modulates neutrophil chemotaxis via targeting Cathepsin B in zebrafish Fish Shellfish Immunol (2024) 154, 109933-109933. PubMed Europe PubMed DOI K
Yadav,S., Vashisth,C., Chaudhri,V., Singh,K., Raghav,N. and Pundeer,R. Development of potential cathepsin B inhibitors: Synthesis of new bithiazole derivatives, in vitro studies supported with theoretical docking studies Int J Biol Macromol (2024) 281, 136290-136290. PubMed Europe PubMed DOI I
Zierke,L., John,D., Gischke,M., Tran,Q.T., Sendler,M., Weiss,F.U., Bornscheuer,U.T., Ritter,C., Lerch,M.M. and Aghdassi,A.A. Initiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules Cell Mol Life Sci (2024) 81, 207-207. PubMed Europe PubMed DOI PMC EPMC

2023

Chou,M.Y., Liu,D., An,J., Xu,Y. and Cyster,J.G. B cell peripheral tolerance is promoted by cathepsin B protease Proc Natl Acad Sci U S A (2023) 120, e2300099120-e2300099120. PubMed Europe PubMed DOI PMC EPMC
Egorova,V.S., Kolesova,E.P., Lopus,M., Yan,N., Parodi,A. and Zamyatnin,A.A., Jr. Smart Delivery Systems Responsive to Cathepsin B Activity for Cancer Treatment Pharmaceutics (2023) 15 PubMed Europe PubMed DOI PMC EPMC V
Hirose,H., Nakata,E., Zhang,Z., Shibano,Y., Maekawa,M., Morii,T. and Futaki,S. Macropinoscope: Real-Time Simultaneous Tracking of pH and Cathepsin B Activity in Individual Macropinosomes Anal Chem (2023) 95, 11410-11419. PubMed Europe PubMed DOI
Katsumata-Kato,O., Yokoyama,M. and Fujita-Yoshigaki,J. The secretory ability of newly formed secretory granules is regulated by pro-cathepsin B and amylase in parotid glands Biochem Biophys Res Commun (2023) 666, 45-51. PubMed Europe PubMed DOI
Li,X., Zhang,M., Zhang,H., Wang,Z. and Zhang,H. Upconversion nanoparticle-based fluorescence resonance energy transfer sensing platform for the detection of cathepsin B activity in vitro and in vivo Mikrochim Acta (2023) 190, 181-181. PubMed Europe PubMed DOI
Ma,Y., Shang,J., Liu,L., Li,M., Xu,X., Cao,H., Xu,L., Sun,W., Song,G. and Zhang,X.B. Rational Design of a Double-Locked Photoacoustic Probe for Precise In Vivo Imaging of Cathepsin B in Atherosclerotic Plaques J Am Chem Soc (2023) 145, 17881-17891. PubMed Europe PubMed DOI
Nguyen,T., Kumar,R.P. and Park,P.H. Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes Arch Pharm Res (2023) 46, 160-176. PubMed Europe PubMed DOI
Saroha,B., Kumar,G., Arya,P., Raghav,N. and Kumar,S. Some morpholine tethered novel aurones: Design, synthesis, biological, kinetic and molecular docking studies Bioorg Chem (2023) 140, 106805-106805. PubMed Europe PubMed DOI
Shang,X.K., Zhang,S.M. and Ni,J.J. Research progress of cathepsin B in brain aging and Alzheimer's diseases Yi Chuan (2023) 45, 212-220. PubMed Europe PubMed DOI V
Stoka,V., Vasiljeva,O., Nakanishi,H. and Turk,V. The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC V
Tusar,L., Loboda,J., Impens,F., Sosnowski,P., Van Quickelberghe,E., Vidmar,R., Demol,H., Sedeyn,K., Saelens,X., Vizovisek,M., Mihelic,M., Fonovic,M., Horvat,J., Kosec,G., Turk,B., Gevaert,K. and Turk,D. Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins Commun Biol (2023) 6, 450-450. PubMed Europe PubMed DOI PMC EPMC
Weekley,B.H. and Rice,J.C. The MMP-2 histone H3 N-terminal tail protease is selectively targeted to the transcription start sites of active genes Epigenetics Chromatin (2023) 16, 16-16. PubMed Europe PubMed DOI PMC EPMC
Wu,Y., Mumford,P., Noy,S., Cleverley,K., Mrzyglod,A., Luo,D., van Dalen,F., Verdoes,M., Fisher,E.M.C. and Wiseman,F.K. Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B Acta Neuropathol Commun (2023) 11, 132-132. PubMed Europe PubMed DOI PMC EPMC
Xie,Z., Zhao,M., Yan,C., Kong,W., Lan,F., Narengaowa, Zhao,S., Yang,Q., Bai,Z., Qing,H. and Ni,J. Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways Cell Death Dis (2023) 14, 255-255. PubMed Europe PubMed DOI PMC EPMC V
Xu,L.B., Qin,Y.F., Su,L., Huang,C., Xu,Q., Zhang,R., Shi,X.D., Sun,R., Chen,J., Song,Z., Jiang,X., Shang,L., Xiao,G., Kong,X., Liu,C. and Wong,P.P. Cathepsin-facilitated invasion of BMI1-high hepatocellular carcinoma cells drives bile duct tumor thrombi formation Nat Commun (2023) 14, 7033-7033. PubMed Europe PubMed DOI PMC EPMC
Yoon,M.C., Phan,V., Podvin,S., Mosier,C., O'Donoghue,A.J. and Hook,V. Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range Biochemistry (2023) 62, 2289-2300. PubMed Europe PubMed DOI PMC EPMC

2022

Gomez-Alonso,I.S., Martinez-Garcia,S., Betanzos-Cabrera,G., Juarez,E., Sarabia-Leon,M.C., Herrera,M.T., Gomez-Chavez,F., Sanchez-Torres,L., Rodriguez-Martinez,S., Cancino-Diaz,M.E., Cancino,J. and Cancino-Diaz,J.C. Low Concentration of the Neutrophil Proteases Cathepsin G, Cathepsin B, Proteinase-3 and Metalloproteinase-9 Induce Biofilm Formation in Non-Biofilm-Forming Staphylococcus epidermidis Isolates Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC
Hook,G., Reinheckel,T., Ni,J., Wu,Z., Kindy,M., Peters,C. and Hook,V. Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders Pharmacol Rev (2022) 74, 600-629. PubMed Europe PubMed DOI V
Ni,J., Lan,F., Xu,Y., Nakanishi,H. and Li,X. Extralysosomal cathepsin B in central nervous system: Mechanisms and therapeutic implications Brain Pathol (2022) , e13071-e13071. PubMed Europe PubMed DOI V
Yan,W., Feng,Y., Lei,Z., Kuang,W. and Long,C. MicroRNA-214-3p Ameliorates LPS-Induced Cardiomyocyte Injury by Inhibiting Cathepsin B Folia Biol (Praha) (2022) 68, 78-85. PubMed Europe PubMed
Yang,X., Yin,H., Zhang,D., Peng,L., Li,K., Cui,F., Xia,C., Li,Z. and Huang,H. Bibliometric Analysis of Cathepsin B Research From 2011 to 2021 Front Med (Lausanne) (2022) 9, 898455-898455. PubMed Europe PubMed DOI PMC EPMC
Yoon,M.C., Hook,V. and O'Donoghue,A.J. Cathepsin B Dipeptidyl Carboxypeptidase and Endopeptidase Activities Demonstrated across a Broad pH Range Biochemistry (2022) 61, 1904-1914. PubMed Europe PubMed DOI PMC EPMC
Yoon,M.C., Christy,M.P., Phan,V.V., Gerwick,W.H., Hook,G., O'Donoghue,A.J. and Hook,V. Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B Biochemistry (2022) 61, 228-238. PubMed Europe PubMed DOI I
Zhang,Z., Nakata,E., Shibano,Y. and Morii,T. FRET-Based Cathepsin Probes for Simultaneous Detection of Cathepsin B and D Activities Chembiochem (2022) 23, e202200319-e202200319. PubMed Europe PubMed DOI

2021

Akinyemi,A.O., Pereira,G.B.S. and Rocha,F.V. Role of cathepsin B in cancer progression: a potential target for coordination compounds Mini Rev Med Chem (2021) PubMed Europe PubMed DOI V
Bollavaram,K., Leeman,T.H., Lee,M.W., Kulkarni,A., Upshaw,S.G., Yang,J., Song,H. and Platt,M.O. Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V Protein Sci (2021) PubMed Europe PubMed DOI
Chen,X., Ren,X., Zhu,Y., Fan,Z., Zhang,L., Liu,Z., Dong,L. and Hai,Z. Cathepsin B-Activated Fluorescent and Photoacoustic Imaging of Tumor Anal Chem (2021) 93, 9304-9308. PubMed Europe PubMed DOI
Chitranshi,N., Kumar,A., Sheriff,S., Gupta,V., Godinez,A., Saks,D., Sarkar,S., Shen,T., Mirzaei,M., Basavarajappa,D., Abyadeh,M., Singh,S.K., Dua,K., Zhang,K.Y.J., Graham,S.L. and Gupta,V. Identification of Novel Cathepsin B Inhibitors with Implications in Alzheimer's Disease: Computational Refining and Biochemical Evaluation Cells (2021) 10 PubMed Europe PubMed DOI PMC EPMC
Dominguez-Hernandez,E. and Ertbjerg,P. Effect of LTLT heat treatment on cathepsin B and L activities and denaturation of myofibrillar proteins of pork Meat Sci (2021) 175, 108454-108454. PubMed Europe PubMed DOI
Fujimoto,T., Tsunedomi,R., Matsukuma,S., Yoshimura,K., Oga,A., Fujiwara,N., Fujiwara,Y., Matsui,H., Shindo,Y., Tokumitsu,Y., Suzuki,N., Kobayashi,S., Hazama,S., Eguchi,H. and Nagano,H. Cathepsin B is highly expressed in pancreatic cancer stem-like cells and is associated with patients' surgical outcomes Oncol Lett (2021) 21, 30-30. PubMed Europe PubMed DOI PMC EPMC
Gu,Y., Zhu,Y., Deng,G., Liu,S., Sun,Y. and Lv,W. Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation Int Immunopharmacol (2021) 93, 107375-107375. PubMed Europe PubMed DOI I
Huang,Y., Chen,Z., Gu,Q., Gu,Z., Wu,X. and Yu,X. CA-074Me inhibits cathepsin-B and alleviates fibrosis after myocardial infarction Panminerva Med (2021) 63, 397-398. PubMed Europe PubMed DOI U I
IstIflI,E.S., SihoGlu Tepe,A., Netz,P.A., SarikUrkcU,C., Kilic,I.H. and Tepe,B. Determination of the interaction between the receptor binding domain of 2019-nCoV spike protein, TMPRSS2, cathepsin B and cathepsin L, and glycosidic and aglycon forms of some flavonols Turk J Biol (2021) 45, 484-502. PubMed Europe PubMed DOI PMC EPMC
Knopp,R.C., Jastaniah,A., Dubrovskyi,O., Gaisina,I., Tai,L. and Thatcher,G.R.J. Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma ACS Pharmacol Transl Sci (2021) 4, 372-385. PubMed Europe PubMed DOI PMC EPMC
Liu,L. and Doray,B. Elevated mRNA expression and defective processing of cathepsin D in HeLa cells lacking the mannose 6-phosphate pathway FEBS Open Bio (2021) 11, 1695-1703. PubMed Europe PubMed DOI
Malla,R.R., Gopinath,S., Gondi,C.S., Alapati,K., Dinh,D.H., Tsung,A.J. and Rao,J.S. Retraction Note to: uPAR and cathepsin B downregulation induces apoptosis by targeting calcineurin A to BAD via Bcl-2 in glioma J Neurooncol (2021) 152, 417-417. PubMed Europe PubMed DOI PMC EPMC
Nagahama,M., Kobayashi,K., Ochi,S. and Takehara,M. Internalization of Clostridium botulinum C2 Toxin Is Regulated by Cathepsin B Released from Lysosomes Toxins (Basel) (2021) 13 PubMed Europe PubMed DOI PMC EPMC
Nagahama,M., Kobayashi,K. and Takehara,M. Cathepsin Release from Lysosomes Promotes Endocytosis of Clostridium perfringens Iota-Toxin Toxins (Basel) (2021) 13 PubMed Europe PubMed DOI PMC EPMC
Pathak,M., Vani,V. and Seshagiri,P.B. Expression and function of interleukin-1beta is required for hamster blastocyst hatching: Involvement of hatching-associated cathepsin proteases Mol Reprod Dev (2021) 88, 274-286. PubMed Europe PubMed DOI
Shen,Y., Wu,T., Wang,Y., Zhang,S.L., Zhao,X., Chen,H.Y. and Xu,J.J. Nucleolin-Targeted Ratiometric Fluorescent Carbon Dots with a Remarkably Large Emission Wavelength Shift for Precise Imaging of Cathepsin B in Living Cancer Cells Anal Chem (2021) 93, 4042-4050. PubMed Europe PubMed DOI
Steuten,K., Kim,H., Widen,J.C., Babin,B.M., Onguka,O., Lovell,S., Bolgi,O., Cerikan,B., Neufeldt,C.J., Cortese,M., Muir,R.K., Bennett,J.M., Geiss-Friedlander,R., Peters,C., Bartenschlager,R. and Bogyo,M. Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19 ACS Infect Dis (2021) PubMed Europe PubMed DOI PMC EPMC
Talukdar,R., Aslam,M., Reddy,D.N., Nabi,Z., Shava,U., Ravikanth,V.V., Avanthi,S. and Govardhan,B. Pancreas Divisum Increases the Risk of Recurrent Acute Pancreatitis in Patients with rs12338 Polymorphism in the Cathepsin B Gene Dig Dis Sci (2021) 66, 2283-2290. PubMed Europe PubMed DOI
Tran,A.P. and Silver,J. Cathepsins in neuronal plasticity Neural Regen Res (2021) 16, 26-35. PubMed Europe PubMed DOI
Wang,J., Wang,L., Zhang,X., Xu,Y., Chen,L., Zhang,W., Liu,E., Xiao,C. and Kou,Q. Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis Int Immunopharmacol (2021) 94, 107496-107496. PubMed Europe PubMed DOI I
Yang,J., Chen,T. and Zhou,Y. Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes Hereditas (2021) 158, 4-4. PubMed Europe PubMed DOI PMC EPMC

2020

Abhinand,C.S., Nair,A.S., Krishnamurthy,A., Oommen,O.V. and Sudhakaran,P.R. Potential protease inhibitors and their combinations to block SARS-CoV-2 J Biomol Struct Dyn (2020) , 1-15. PubMed Europe PubMed DOI PMC EPMC I
Amouzadeh Tabrizi,M., Ferre-Borrull,J. and Marsal,L.F. An optical biosensor for the determination of cathepsin B as a cancer-associated enzyme using nanoporous anodic alumina modified with human serum albumin-thionine Mikrochim Acta (2020) 187, 230-230. PubMed Europe PubMed DOI A
Anderson,M.J., Song,Y., Fan,H., Wright,J.G., Ren,Z., Hua,D.H., Koehne,J.E., Meyyappan,M. and Li,J. Simultaneous, multiplex quantification of protease activities using a gold microelectrode array Biosens Bioelectron (2020) 165, 112330-112330. PubMed Europe PubMed DOI A
Balboula,A.Z., Schindler,K., Kotani,T., Kawahara,M. and Takahashi,M. Vitrification-induced activation of lysosomal cathepsin B perturbs spindle assembly checkpoint function in mouse oocytes Mol Hum Reprod (2020) PubMed Europe PubMed DOI
Carrilho,M.R., Scaffa,P., Oliveira,V., Tjaderhane,L., Tersariol,I.L., Pashley,D.H., Tay,F. and Nascimento,F.D. Insights into cathepsin-B activity in mature dentin matrix Arch Oral Biol (2020) 117, 104830-104830. PubMed Europe PubMed DOI
Chevriaux,A., Pilot,T., Derangere,V., Simonin,H., Martine,P., Chalmin,F., Ghiringhelli,F. and Rebe,C. Cathepsin B is required for NLRP3 inflammasome activation in macrophages, through NLRP3 interaction Front Cell Dev Biol (2020) 8, 167-167. PubMed Europe PubMed DOI PMC EPMC
Cosgrove,J., Novkovic,M., Albrecht,S., Pikor,N.B., Zhou,Z., Onder,L., Morbe,U., Cupovic,J., Miller,H., Alden,K., Thuery,A., O'Toole,P., Pinter,R., Jarrett,S., Taylor,E., Venetz,D., Heller,M., Uguccioni,M., Legler,D.F., Lacey,C.J., Coatesworth,A., Polak,W.G., Cupedo,T., Manoury,B., Thelen,M., Stein,J.V., Wolf,M., Leake,M.C., Timmis,J., Ludewig,B. and Coles,M.C. B cell zone reticular cell microenvironments shape CXCL13 gradient formation Nat Commun (2020) 11, 3677-3677. PubMed Europe PubMed DOI PMC EPMC
Dai,Z., Cheng,Q. and Zhang,Y. Rational design of a humanized antibody inhibitor of cathepsin B Biochemistry (2020) 59, 1420-1427. PubMed Europe PubMed DOI
Domagalski,J.T., Xifre-Perez,E., Tabrizi,M.A., Ferre-Borrull,J. and Marsal,L.F. Magnetic nanoparticle decorated anodic alumina nanotubes for fluorescent detection of cathepsin B J Colloid Interface Sci (2020) 584, 236-245. PubMed Europe PubMed DOI A
Filippova,I.Y., Dvoryakova,E.A., Sokolenko,N.I., Simonyan,T.R., Tereshchenkova,V.F., Zhiganov,N.I., Dunaevsky,Y.E., Belozersky,M.A., Oppert,B. and Elpidina,E.N. New Glutamine-Containing Substrates for the Assay of Cysteine Peptidases From the C1 Papain Family Front Mol Biosci (2020) 7, 578758-578758. PubMed Europe PubMed DOI PMC EPMC
Hadi,M.M., Nesbitt,H., Masood,H., Sciscione,F., Patel,S., Ramesh,B.S., Emberton,M., Callan,J.F., Macrobert,A., McHale,A.P. and Nomikou,N. Investigating the performance of a novel pH and cathepsin B sensitive, stimulus-responsive nanoparticle for optimised sonodynamic therapy in prostate cancer J Control Release (2020) 329, 76-86. PubMed Europe PubMed DOI
Han,L., Xu,D., Xi,Z., Wu,M., Nik Nabil,W.N., Zhang,J., Sui,H., Fu,W., Zhou,H., Lao,Y., Xu,G., Guo,C. and Xu,H. The Natural Compound Oblongifolin C Exhibits Anticancer Activity by Inhibiting HSPA8 and Cathepsin B In Vitro Front Pharmacol (2020) 11, 564833-564833. PubMed Europe PubMed DOI PMC EPMC I
Han,Y., Yue,X., Hu,C.X., Liu,F., Liu,R.D., He,M.M., Long,S.R., Cui,J. and Wang,Z.Q. Interaction of a Trichinella spiralis cathepsin B with enterocytes promotes the larval intrusion into the cells Res Vet Sci (2020) 130, 110-117. PubMed Europe PubMed DOI
Herceg,V., Bouilloux,J., Janikowska,K., Allemann,E. and Lange,N. Cathepsin B-Cleavable Cyclopeptidic Chemotherapeutic Prodrugs Molecules (2020) 25 PubMed Europe PubMed DOI PMC EPMC
Hook,V., Yoon,M., Mosier,C., Ito,G., Podvin,S., Head,B.P., Rissman,R., O'Donoghue,A.J. and Hook,G. Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders Biochim Biophys Acta Proteins Proteom (2020) , 140428-140428. PubMed Europe PubMed DOI
Hu,S., Gong,H., Zhu,J., Rong,Y., Zhao,Y., Lu,Y., Li,L. and Wang,J. Molecular characterisation, tissue distribution, and expression profiling of the cathepsin b gene during ovarian follicle development in geese Br Poult Sci (2020) PubMed Europe PubMed DOI
Izumida,M., Hayashi,H., Tanaka,A. and Kubo,Y. Cathepsin B Protease Facilitates Chikungunya Virus Envelope Protein-Mediated Infection via Endocytosis or Macropinocytosis Viruses (2020) 12 PubMed Europe PubMed DOI K
Jaimes,J., Millet,J. and Whittaker,G. Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site SSRN (2020) , 3581359-3581359. PubMed Europe PubMed DOI PMC EPMC
Jastaniah,A., Gaisina,I.N., Knopp,R.C. and Thatcher,G.R.J. Synthesis of alpha-Ketoamide-Based Stereoselective Calpain-1 Inhibitors as Neuroprotective Agents ChemMedChem (2020) PubMed Europe PubMed DOI I
Jiang,M., Meng,J., Zeng,F., Qing,H., Hook,G., Hook,V., Wu,Z. and Ni,J. Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling J Neurochem (2020) PubMed Europe PubMed DOI I
Jin,X., Zhang,J., Jin,X., Liu,L. and Tian,X. Folate Receptor Targeting and Cathepsin B-Sensitive Drug Delivery System for Selective Cancer Cell Death and Imaging ACS Med Chem Lett (2020) 11, 1514-1520. PubMed Europe PubMed DOI PMC EPMC
Kianifard,L., Yakhchali,M. and Imani,M. The Effects of pH and Temperature on Cysteine Protease (Cathepsin B) Activity in Miracidia and Eggs of Fasciola hepatica Iran J Parasitol (2020) 15, 233-239. PubMed Europe PubMed PMC EPMC
Kim,E.K., Song,M.J., Jang,H.H. and Chung,Y.S. Clinicopathologic Analysis of Cathepsin B as a Prognostic Marker of Thyroid Cancer Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC
Kuang,F., Liu,J., Li,C., Kang,R. and Tang,D. Cathepsin B is a mediator of organelle-specific initiation of ferroptosis Biochem Biophys Res Commun (2020) 533, 1464-1469. PubMed Europe PubMed DOI
Li,H., Xie,L., Chen,L., Zhang,L., Han,Y., Yan,Z. and Guo,X. Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer Aging (Albany NY) (2020) 12, 22370-22389. PubMed Europe PubMed DOI
Li,Y., He,Z., Lv,H., Chen,W. and Chen,J. Calpain-2 plays a pivotal role in the inhibitory effects of propofol against TNF-alpha-induced autophagy in mouse hippocampal neurons J Cell Mol Med (2020) PubMed Europe PubMed DOI PMC EPMC
Liu,C., Cai,Z., Hu,T., Yao,Q. and Zhang,L. Cathepsin B aggravated doxorubicininduced myocardial injury via NFkappaB signalling Mol Med Rep (2020) 22, 4848-4856. PubMed Europe PubMed DOI PMC EPMC K
Liu,Y., Xie,Y., Lin,Y., Xu,Q., Huang,Y., Peng,M., Lai,W. and Zheng,Y. Cepharanthine as a Potential Novel Tumor-Regional Therapy in Treating Cutaneous Melanoma: Altering the Expression of Cathepsin B, Tumor Suppressor Genes and Autophagy-Related Proteins Front Bioeng Biotechnol (2020) 8, 601969-601969. PubMed Europe PubMed DOI PMC EPMC
Maeser,S., Petre,B.A., Ion,L., Rawer,S., Kohlschutter,A., Santorelli,F.M., Simonati,A., Schulz,A. and Przybylski,M. Enzymatic diagnosis of neuronal lipofuscinoses in dried blood spots using substrates for concomitant tandem mass spectrometry and fluorimetry J Mass Spectrom (2020) , e4675-e4675. PubMed Europe PubMed DOI
Matos,T.K.B., Batista,P.H.J., Dos Reis Rocho,F., De Vita,D., Pearce,N., Kellam,B., Montanari,C.A. and Leitao,A. Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB Bioorg Med Chem Lett (2020) 30, 127439-127439. PubMed Europe PubMed DOI I
Mellott,D., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D., Hsu,J.C., Zhu,J., Taylor,Z., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Beck,S., Carlin,A.F., Clark,A.E., Berreta,L., Maneval,D., Frueh,F., Hurst,B.L., Wang,H., Kocurek,K.I., Raushel,F.M., O'Donoghue,A., Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H. A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC I
Mizunoe,Y., Kobayashi,M., Hoshino,S., Tagawa,R., Itagawa,R., Hoshino,A., Okita,N., Sudo,Y., Nakagawa,Y., Shimano,H. and Higami,Y. Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes Sci Rep (2020) 10, 634-634. PubMed Europe PubMed DOI PMC EPMC
Morrone,C., Smirnova,N.F., Jeridi,A., Kneidinger,N., Hollauer,C., Schupp,J.C., Kaminski,N., Jenne,D., Eickelberg,O. and Yildirim,A.O. Cathepsin B promotes collagen biosynthesis driving Bronchiolitis Obliterans Syndrome Eur Respir J (2020) PubMed Europe PubMed DOI
Nagakannan,P., Islam,M.I., Conrad,M. and Eftekharpour,E. Cathepsin B is an executioner of ferroptosis Biochim Biophys Acta Mol Cell Res (2020) 1868, 118928-118928. PubMed Europe PubMed DOI
Nakanishi,H. Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging Neural Regen Res (2020) 15, 25-29. PubMed Europe PubMed DOI
Nakanishi,H., Nonaka,S. and Wu,Z. Microglial cathepsin B and Porphyromonas gingivalis gingipains as potential therapeutic targets for sporadic Alzheimer's disease CNS Neurol Disord Drug Targets (2020) PubMed Europe PubMed DOI
Nettesheim,A., Shim,M.S., Dixon,A., Raychaudhuri,U., Gong,H. and Liton,P.B. Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma J Clin Med (2020) 10 PubMed Europe PubMed DOI PMC EPMC
Niu,R., Wang,J., Geng,C., Li,Y., Dong,L., Liu,L., Chang,Y., Shen,J., Nie,Z., Zhang,Y. and Hu,B. Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy Aging (Albany NY) (2020) 12 PubMed Europe PubMed DOI
Oberstein,T.J., Utz,J., Spitzer,P., Klafki,H.W., Wiltfang,J., Lewczuk,P., Kornhuber,J. and Maler,J.M. The Role of Cathepsin B in the Degradation of Abeta and in the Production of Abeta Peptides Starting With Ala2 in Cultured Astrocytes Front Mol Neurosci (2020) 13, 615740-615740. PubMed Europe PubMed DOI PMC EPMC
Padmanabhan,P., Desikan,R. and Dixit,N.M. Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection PLoS Comput Biol (2020) 16, e1008461-e1008461. PubMed Europe PubMed DOI
Peintner,L., Venkatraman,A., Waeldin,A., Hofherr,A., Busch,T., Voronov,A., Viau,A., Kuehn,E.W., Kottgen,M. and Borner,C. Loss of PKD1/polycystin-1 impairs lysosomal activity in a CAPN (calpain)-dependent manner Autophagy (2020) , 1-17. PubMed Europe PubMed DOI I
Riaz,S., Abdulrahman,N., Uddin,S., Jabeen,A., Gadeau,A.P., Fliegel,L. and Mraiche,F. Anti-hypertrophic effect of Na(+)/H(+) exchanger-1 inhibition is mediated by reduced cathepsin B Eur J Pharmacol (2020) 888, 173420-173420. PubMed Europe PubMed DOI I
Seth,S., Batra,J. and Srinivasan,S. COVID-19: Targeting Proteases in Viral Invasion and Host Immune Response Front Mol Biosci (2020) 7, 215-215. PubMed Europe PubMed DOI PMC EPMC V
Sharma,C. and Kang,S.C. Molecular dynamic simulation (MDS) and in vitro cathepsin-B inhibitory activity of decrusin angelate, ibuprofen, and thymol Nat Prod Res (2020) , 1-6. PubMed Europe PubMed DOI
Sharma,T., Harioudh,M.K., Kuldeep,J., Kumar,S., Banerjee,D., Ghosh,J.K. and Siddiqi,M.I. Identification of potential inhibitors of cathepsin-B using shape & pharmacophore-based virtual screening, molecular docking and explicit water thermodynamics Mol Inform (2020) 39, e1900023-e1900023. PubMed Europe PubMed DOI I
Ulcakar,L. and Novinec,M. Inhibition of Human Cathepsins B and L by Caffeic Acid and Its Derivatives Biomolecules (2020) 11 PubMed Europe PubMed DOI PMC EPMC
Van de Walle,T., Briand,M., Mitrovic,A., Sosic,I., Gobec,S., Kos,J., Persoons,L., Daelemans,D., De Jonghe,S., Ubiparip,Z., Desmet,T., Van Hecke,K., Mangelinckx,S. and D'hooghe,M. Synthesis of Novel Nitroxoline Analogs with Potent Cathepsin B Exopeptidase Inhibitory Activity ChemMedChem (2020) 15, 2477-2490. PubMed Europe PubMed DOI I
Viana,G.M., Gonzalez,E.A., Alvarez,M.M.P., Cavalheiro,R.P., do Nascimento,C.C., Baldo,G., D'Almeida,V., de Lima,M.A., Pshezhetsky,A.V. and Nader,H.B. Cathepsin B-associated activation of amyloidogenic pathway in murine mucopolysaccharidosis type I brain cortex Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI
Voisin,A., Monville,C., Plancheron,A., Bere,E., Gaillard,A. and Leveziel,N. Corrigendum to "Cathepsin B pH-Dependent Activity Is Involved in Lysosomal Dysregulation in Atrophic Age-Related Macular Degeneration" Oxid Med Cell Longev (2020) 2020, 3510764-3510764. PubMed Europe PubMed DOI PMC EPMC
Wang,H., Wang,Z., Wang,L., Sun,L., Liu,W., Li,Q. and Wang,J. IL-6 promotes collagen-induced arthritis by activating the NLRP3 inflammasome through the cathepsin B/S100A9-mediated pathway Int Immunopharmacol (2020) 88, 106985-106985. PubMed Europe PubMed DOI
Wang,R., Liu,J., Di Giuseppe,G. and Liang,A. UAA and UAG may encode amino acid in cathepsin B gene of Euplotes octocarinatus J Eukaryot Microbiol (2020) 67, 144-149. PubMed Europe PubMed DOI
Wang,S.J., Chao,D., Wei,W., Nan,G., Li,J.Y., Liu,F.L., Li,L., Jiang,J.L., Cui,H.Y. and Chen,Z.N. CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma J Exp Clin Cancer Res (2020) 39, 145-145. PubMed Europe PubMed DOI PMC EPMC
Wang,Y., Jiang,L., Zhang,Y., Lu,Y., Li,J., Wang,H., Yao,D. and Wang,D. Fibronectin-Targeting and Cathepsin B-Activatable Theranostic Nanoprobe for MR/Fluorescence Imaging and Enhanced Photodynamic Therapy for Triple Negative Breast Cancer ACS Appl Mater Interfaces (2020) 12, 33564-33574. PubMed Europe PubMed DOI
Wang,Z.Y., Zhang,C.P. and Zhang,C.Y. Integration of a peptide-DNA conjugate with multiple cyclic signal amplification for the ultrasensitive detection of cathepsin B activity Chem Commun (Camb) (2020) 56, 2119-2122. PubMed Europe PubMed DOI A
Yu,C., Wan,Y., Piao,L. and Wu Cheng,X. Can cysteinyl cathepsin activity control diet-induced NAFLD? Int J Cardiol Heart Vasc (2020) 28, 100516-100516. PubMed Europe PubMed DOI PMC EPMC
Zhao,X.D., Zhang,B.W., Fu,L.J., Li,Q.L., Lin,Y. and Yu,X.Q. Possible insecticidal mechanism of Cry41-related toxin against Myzus persicae by enhancing cathepsin B activity J Agric Food Chem (2020) 68, 4607-4615. PubMed Europe PubMed DOI

2019

Cantres-Rosario,Y.M., Ortiz-Rodriguez,S.C., Santos-Figueroa,A.G., Plaud,M., Negron,K., Cotto,B., Langford,D. and Melendez,L.M. HIV Infection induces extracellular cathepsin B uptake and damage to neurons Sci Rep (2019) 9, 8006-8006. PubMed Europe PubMed DOI
Chen,C.H., Bhasin,S., Khanna,P., Joshi,M., Joslin,P.M., Saxena,R., Amin,S., Liu,S., Sindhu,S., Walker,S.R., Catalano,P., Frank,D.A., Alper,S.L., Bhasin,M. and Bhatt,R.S. Study of cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts Oncogenesis (2019) 8, 15-15. PubMed Europe PubMed DOI PMC EPMC
Cui,J., Han,Y., Yue,X., Liu,F., Song,Y.Y., Yan,S.W., Lei,J.J., Zhang,X., Jiang,P. and Wang,Z.Q. Vaccination of mice with a recombinant novel cathepsin B inhibits Trichinella spiralis development, reduces the fecundity and worm burden Parasit Vectors (2019) 12, 581-581. PubMed Europe PubMed DOI PMC EPMC
Demcsak,A., Geisz,A. and Sahin-Toth,M. Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B Sci Rep (2019) 9, 9188-9188. PubMed Europe PubMed DOI PMC EPMC
Dheer,D., Nicolas,J. and Shankar,R. Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases Adv Drug Deliv Rev (2019) 151-152, 130-151. PubMed Europe PubMed DOI V
Karnthaler-Benbakka,C., Koblmuller,B., Mathuber,M., Holste,K., Berger,W., Heffeter,P., Kowol,C.R. and Keppler,B.K. Synthesis, characterization and in vitro studies of a cathepsin B-cleavable prodrug of the VEGFR inhibitor Sunitinib Chem Biodivers (2019) 16, e1800520-e1800520. PubMed Europe PubMed DOI
Mitrovic,A., Kljun,J., Sosic,I., Ursic,M., Meden,A., Gobec,S., Kos,J. and Turel,I. Organoruthenated nitroxoline derivatives impair tumor cell invasion through inhibition of cathepsin B activity Inorg Chem (2019) 58, 12334-12347. PubMed Europe PubMed DOI I
Ni,Y., Hai,Z., Zhang,T., Wang,Y., Yang,Y., Zhang,S. and Liang,G. Cathepsin B turning bioluminescence "on" for tumor imaging Anal Chem (2019) 91, 14834-14837. PubMed Europe PubMed DOI L
Pandey,G., Bakhshi,S., Kumar,M., Thakur,B., Jain,P., Kaur,P. and Chauhan,S.S. Prognostic and therapeutic relevance of cathepsin B in pediatric acute myeloid leukemia Am J Cancer Res (2019) 9, 2634-2649. PubMed Europe PubMed PMC EPMC
Poreba,M., Groborz,K., Vizovisek,M., Maruggi,M., Turk,D., Turk,B., Powis,G., Drag,M. and Salvesen,G.S. Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples Chem Sci (2019) 10, 8461-8477. PubMed Europe PubMed DOI PMC EPMC L
Schmitz,J., Gilberg,E., Loser,R., Bajorath,J., Bartz,U. and Gutschow,M. Cathepsin B: active site mapping with peptidic substrates and inhibitors Bioorg Med Chem (2019) 27, 1-15. PubMed Europe PubMed DOI
Schwenck,J., Maurer,A., Fehrenbacher,B., Mehling,R., Knopf,P., Mucha,N., Haupt,D., Fuchs,K., Griessinger,C.M., Bukala,D., Holstein,J., Schaller,M., Menendez,I.G., Ghoreschi,K., Quintanilla-Martinez,L., Gutschow,M., Laufer,S., Reinheckel,T., Rocken,M., Kalbacher,H., Pichler,B.J. and Kneilling,M. Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions Theranostics (2019) 9, 3903-3917. PubMed Europe PubMed DOI PMC EPMC K
Shim,M.K., Park,J., Yoon,H.Y., Lee,S., Um,W., Kim,J.H., Kang,S.W., Seo,J.W., Hyun,S.W., Park,J.H., Byun,Y., Kwon,I.C. and Kim,K. Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy J Control Release (2019) 294, 376-389. PubMed Europe PubMed DOI
Singh,G., Jayadev Magani,S.K., Sharma,R., Bhat,B., Shrivastava,A., Chinthakindi,M. and Singh,A. Structural, functional and molecular dynamics analysis of cathepsin B gene SNPs associated with tropical calcific pancreatitis, a rare disease of tropics PeerJ (2019) 7, e7425-e7425. PubMed Europe PubMed DOI PMC EPMC M
Sung,S.A., Kim,D.H., Oh,K.H., Han,S.Y. and Han,K.H. The role of cathepsin B in peritoneal fibrosis due to peritoneal dialysis Int J Nephrol (2019) 2019, 4150656-4150656. PubMed Europe PubMed DOI PMC EPMC U
Toupin,N.P., Arora,K., Shrestha,P., Peterson,J.A., Fischer,L.J., Rajagurubandara,E., Podgorski,I., Winter,A.H. and Kodanko,J.J. BODIPY-Caged photoactivated inhibitors of cathepsin B flip the light switch on cancer cell apoptosis ACS Chem Biol (2019) 14, 2833-2840. PubMed Europe PubMed DOI I
Voisin,A., Monville,C., Plancheron,A., Bere,E., Gaillard,A. and Leveziel,N. Cathepsin B pH-dependent activity is involved in lysosomal dysregulation in atrophic age-related macular degeneration Oxid Med Cell Longev (2019) 2019, 5637075-5637075. PubMed Europe PubMed DOI PMC EPMC
Wang,Q., Yu,L., Wong,R.C.H. and Lo,P.C. Construction of cathepsin B-responsive fluorescent probe and photosensitizer using a ferrocenyl boron dipyrromethene dark quencher Eur J Med Chem (2019) 179, 828-836. PubMed Europe PubMed DOI A L
Wang,S., Vigliarolo,B.G., Chowdhury,M.A., Nyarko,J.N.K., Mousseau,D.D. and Phenix,C.P. Design and synthesis of fluorogenic substrate-based probes for detecting cathepsin B activity Bioorg Chem (2019) 92, 103194-103194. PubMed Europe PubMed DOI A L
Wrona,E., Jakubowska,J., Pawlik,B., Pastorczak,A., Madzio,J., Lejman,M., Sedek,L., Kowalczyk,J., Szczepanski,T. and Mlynarski,W. Gene expression of ASNS, LGMN and CTSB is elevated in a subgroup of childhood BCP-ALL with PAX5 deletion Oncol Lett (2019) 18, 6926-6932. PubMed Europe PubMed DOI PMC EPMC
Wu,J.S., Li,Z.F., Wang,H.F., Yu,X.H., Pang,X., Wu,J.B., Wang,S.S., Zhang,M., Yang,X., Cao,M.X., Tang,Y.J., Liang,X.H., Zheng,M. and Tang,Y.L. Cathepsin B defines leader cells during the collective invasion of salivary adenoid cystic carcinoma Int J Oncol (2019) 54, 1233-1244. PubMed Europe PubMed DOI PMC EPMC T
Zhang,F., Lyon,C.J., Walls,R.J., Ning,B., Fan,J. and Hu,T.Y. Cathepsin B dependent cleavage product of serum amyloid A1 identifies patients with chemotherapy-related cardiotoxicity ACS Pharmacol Transl Sci (2019) 2, 333-341. PubMed Europe PubMed DOI PMC EPMC
Zhang,Y., Chen,Y., Zhang,Y., Li,P.L. and Li,X. Contribution of cathepsin B-dependent Nlrp3 inflammasome activation to nicotine-induced endothelial barrier dysfunction Eur J Pharmacol (2019) , 172795-172795. PubMed Europe PubMed DOI
Zheng,L., Wu,X., Li,S., Liu,B. and Xue,D. Cathepsin B inhibitors block multiple radiation-induced side effects in C. elegans Cell Res (2019) 29, 1042-1045. PubMed Europe PubMed DOI I

2018

Aghdassi,A.A., John,D.S., Sendler,M., Weiss,F.U., Reinheckel,T., Mayerle,J. and Lerch,M.M. Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis J Biol Chem (2018) 293, 1018-1029. PubMed Europe PubMed DOI
Araujo,T.F., Cordeiro,A.V., Vasconcelos,D.A.A., Vitzel,K.F. and Silva,V.R.R. The role of cathepsin B in autophagy during obesity: a systematic review Life Sci (2018) 209, 274-281. PubMed Europe PubMed DOI
Bernstein,H.G. and Keilhoff,G. Putative roles of cathepsin B in Alzheimer's disease pathology: the good, the bad, and the ugly in one? Neural Regen Res (2018) 13, 2100-2101. PubMed Europe PubMed DOI
Chen,N., Ou,Z., Zhang,W., Zhu,X., Li,P. and Gong,J. Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells Cell Prolif (2018) , e12487-e12487. PubMed Europe PubMed DOI
Coleman,M.D., Ha,S.D., Haeryfar,S.M.M., Barr,S.D. and Kim,S.O. Cathepsin B plays a key role in optimal production of the influenza A virus J Virol Antivir Res (2018) 2018, 1-20. PubMed Europe PubMed DOI PMC EPMC I
Dietze,R., Starzinski-Powitz,A., Scheiner-Bobis,G., Tinneberg,H.R., Meinhold-Heerlein,I. and Konrad,L. Lysophosphatidic acid triggers cathepsin B-mediated invasiveness of human endometriotic cells Biochim Biophys Acta Mol Cell Biol Lipids (2018) 1863, 1369-1377. PubMed Europe PubMed DOI I
Feng,P., Zhu,W., Chen,N., Li,P., He,K. and Gong,J. [Cathepsin B in hepatic Kupffer cells regulates activation of TLR4-independent inflammatory pathways in mice with lipopolysaccharide-induced sepsis] Nan Fang Yi Ke Da Xue Xue Bao (2018) 38, 1465-1471. PubMed Europe PubMed DOI
Gnanamony,M. and Gondi,C.S. Targeting the expression of cathepsin B using CRISPR/Cas9 system in mammalian cancer cells Methods Mol Biol (2018) 1731, 123-131. PubMed Europe PubMed DOI K
Gonzalez,E.A., Martins,G.R., Tavares,A.M.V., Viegas,M., Poletto,E., Giugliani,R., Matte,U. and Baldo,G. Cathepsin B inhibition attenuates cardiovascular pathology in mucopolysaccharidosis I mice Life Sci (2018) 196, 102-109. PubMed Europe PubMed DOI I
Hartmann,S., Lopez Cruz,R., Alameh,S., Ho,C.C., Rabideau,A., Pentelute,B.L., Bradley,K.A. and Martchenko,M. Characterization of novel piperidine-based inhibitor of cathepsin B-dependent bacterial toxins and viruses ACS Infect Dis (2018) 4, 1235-1245. PubMed Europe PubMed DOI I
Kumar,A., Daitsh,Y., Ben-Aderet,L., Qiq,O., Elayyan,J., Batshon,G., Reich,E., Maatuf,Y.H., Engel,S. and Dvir-Ginzberg,M. A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage J Cell Sci (2018) 131, jcs214973-jcs214973. PubMed Europe PubMed DOI
Liang,F.R., He,H.S., Zhang,C.W., Xu,X.M., Zeng,Z.P., Yuan,J.P., Hong,Y.H. and Wang,J.H. Molecular cloning and functional characterization of cathepsin B from Nile tilapia (Oreochromis niloticus) Int J Biol Macromol (2018) 116, 71-83. PubMed Europe PubMed DOI
Liang,S., Jiang,H., Shen,X.H., Zhang,J.B. and Kim,N.H. Inhibition of cathepsin B activity prevents deterioration in the quality of in vitro aged porcine oocytes Theriogenology (2018) 116, 103-111. PubMed Europe PubMed DOI I
Llorente,P., Kristen,H., Sastre,I., Toledano-Zaragoza,A., Aldudo,J., Recuero,M. and Bullido,M.J. A free radical-generating system regulates amyloid oligomers: involvement of cathepsin B J Alzheimers Dis (2018) 66, 1397-1408. PubMed Europe PubMed DOI I
Nakao,S., Zandi,S., Sun,D. and Hafezi-Moghadam,A. Cathepsin B-mediated CD18 shedding regulates leukocyte recruitment from angiogenic vessels FASEB J (2018) 32, 143-154. PubMed Europe PubMed DOI
Onming,S., Thongda,W., Li,C., Sawatdichaikul,O., McMillan,N., Klinbunga,S., Peatman,E. and Poompuang,S. Bioinformatics characterization of a cathepsin B transcript from the giant river prawn, Macrobrachium rosenbergii: Homology modeling and expression analysis after Aeromonas hydrophila infection Comp Biochem Physiol B Biochem Mol Biol (2018) 221-222, 18-28. PubMed Europe PubMed DOI
Ryan,L.S. and Lippert,A.R. Ultrasensitive chemiluminescent detection of cathepsin B: insights into the new frontier of chemiluminescent imaging Angew Chem Int Ed Engl (2018) 57, 622-624. PubMed Europe PubMed DOI L
Sendler,M., Weiss,F.U., Golchert,J., Homuth,G., van den Brandt,C., Mahajan,U.M., Partecke,L.I., Doring,P., Gukovsky,I., Gukovskaya,A.S., Wagh,P.R., Lerch,M.M. and Mayerle,J. Cathepsin B-mediated activation of trypsinogen in endocytosing macrophages increases severity of pancreatitis in mice Gastroenterology (2018) 154, 704-718. PubMed Europe PubMed DOI
Sosic,I., Mitrovic,A., Curic,H., Knez,D., Brodnik Zugelj,H., Stefane,B., Kos,J. and Gobec,S. Cathepsin B inhibitors: further exploration of the nitroxoline core Bioorg Med Chem Lett (2018) 28, 1239-1247. PubMed Europe PubMed DOI I
Sun,Y., Carandang,R.R., Harada,Y., Okada,S., Yoshitake,K., Asakawa,S., Nogi,Y., Matsunaga,S. and Takada,K. Lactomycins A-C, dephosphorylated phoslactomycin derivatives that inhibit cathepsin B, from the marine-derived Streptomyces sp. ACT232 Mar Drugs (2018) 16 PubMed Europe PubMed DOI I
Templeman,N.M., Luo,S., Kaletsky,R., Shi,C., Ashraf,J., Keyes,W. and Murphy,C.T. Insulin signaling regulates oocyte quality maintenance with age via cathepsin B activity Curr Biol (2018) 28, 753-760. PubMed Europe PubMed DOI
Thibeaux,S., Siddiqi,S., Zhelyabovska,O., Moinuddin,F., Masternak,M.M. and Siddiqi,S.A. Cathepsin B regulates hepatic lipid metabolism by cleaving liver fatty acid-binding protein J Biol Chem (2018) 293, 1910-1923. PubMed Europe PubMed DOI
Tran,A.P., Sundar,S., Yu,M., Lang,B.T. and Silver,J. Modulation of receptor protein tyrosine phosphatase sigma increases chondroitin sulfate proteoglycan degradation through cathepsin B secretion to enhance axon outgrowth J Neurosci (2018) 38, 5399-5414. PubMed Europe PubMed DOI U
Wang,H.L., Cheng,X., Ding,S.W., Wang,D.W., Chen,C., Xu,C.L. and Xie,H. Molecular identification and functional characterization of the cathepsin B gene (Ab-cb-1) in the plant parasitic nematode Aphelenchoides besseyi PLoS ONE (2018) 13, e0199935-e0199935. PubMed Europe PubMed DOI PMC EPMC
Wang,Y., Jia,L., Shen,J., Wang,Y., Fu,Z., Su,S.A., Cai,Z., Wang,J.A. and Xiang,M. Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis PLoS Pathog (2018) 14, e1006872-e1006872. PubMed Europe PubMed DOI
Wei,B., Gunzner-Toste,J., Yao,H., Wang,T., Wang,J., Xu,Z., Chen,J., Wai,J., Nonomiya,J., Tsai,S.P., Chuh,J., Kozak,K.R., Liu,Y., Yu,S.F., Lau,J., Li,G., Phillips,G.D., Leipold,D., Kamath,A., Su,D., Xu,K., Eigenbrot,C., Steinbacher,S., Ohri,R., Raab,H., Staben,L.R., Zhao,G., Flygare,J.A., Pillow,T.H., Verma,V., Masterson,L.A., Howard,P.W. and Safina,B. Discovery of peptidomimetic antibody-drug conjugate linkers with enhanced protease specificity J Med Chem (2018) 61, 989-1000. PubMed Europe PubMed DOI
Yi,P., Hu,X., Hu,B., Wen,C. and Li,Z. Identification and expression of cathepsin B from the freshwater mussel Cristaria plicata Comp Biochem Physiol B Biochem Mol Biol (2018) 225, 21-28. PubMed Europe PubMed DOI
Zhang,X., Wang,X., Xu,S., Li,X. and Ma,X. Cathepsin B contributes to radioresistance by enhancing homologous recombination in glioblastoma Biomed Pharmacother (2018) 107, 390-396. PubMed Europe PubMed DOI

2017

Akenhead,M.L., Fukuda,S., Schmid-Schonbein,G.W. and Shin,H.Y. Fluid shear-induced cathepsin B release in the control of Mac1-dependent neutrophil adhesion J Leukoc Biol (2017) 102, 117-126. PubMed Europe PubMed DOI
Caculitan,N.G., Dela Cruz Chuh,J., Ma,Y., Zhang,D., Kozak,K.R., Liu,Y., Pillow,T.H., Sadowsky,J., Cheung,T.K., Phung,Q., Haley,B., Lee,B.C., Akita,R.W., Sliwkowski,M.X. and Polson,A.G. Cathepsin B is dispensable for cellular processing of cathepsin B-cleavable antibody-drug conjugates Cancer Res (2017) 77, 7027-7037. PubMed Europe PubMed DOI
Chen,H., Lv,M., Lv,Z., Li,C., Xu,W., Zhang,W., Zhao,X., Duan,X. and Jin,C. Molecular cloning and functional characterization of cathepsin B from the sea cucumber Apostichopus japonicus Fish Shellfish Immunol (2017) 60, 447-457. PubMed Europe PubMed DOI
Chen,X., Lee,D., Yu,S., Kim,G., Lee,S., Cho,Y., Jeong,H., Nam,K.T. and Yoon,J. In vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe Biomaterials (2017) 122, 130-140. PubMed Europe PubMed DOI L
Embury,C.M., Dyavarshetty,B., Lu,Y., Wiederin,J.L., Ciborowski,P., Gendelman,H.E. and Kiyota,T. Cathepsin B improves beta-amyloidosis and learning and memory in models of Alzheimer's disease J Neuroimmune Pharmacol (2017) 12, 340-352. PubMed Europe PubMed DOI U
Farizatto,K.L.G., Ikonne,U.S., Almeida,M.F., Ferrari,M.F.R. and Bahr,B.A. Abeta42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: evidence for protective crosstalk between protein clearance pathways PLoS ONE (2017) 12, e0182895-e0182895. PubMed Europe PubMed DOI I
Kramer,L., Renko,M., Zavrsnik,J., Turk,D., Seeger,M.A., Vasiljeva,O., Grutter,M.G., Turk,V. and Turk,B. Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin Theranostics (2017) 7, 2806-2821. PubMed Europe PubMed DOI PMC EPMC L
Li,S.H., Li,R., Zhong,H.X., Chen,X.H., Liu,A.P., Yang,J., Hu,Q., Ke,Q.Q. and Li,M.L. Immunolocalization of Jian carp (Cyprinus carpio var. Jian) cathepsin B: cloning, expression, characterization, and antibody preparation J Food Sci (2017) 82, 1092-1100. PubMed Europe PubMed DOI
Li,Y.Y., Fang,J. and Ao,G.Z. Cathepsin B and L inhibitors: a patent review (2010 - present) Expert Opin Ther Pat (2017) 27, 643-656. PubMed Europe PubMed DOI V I
Mitrovic,A., Sosic,I., Kos,S., Tratar,U.L., Breznik,B., Kranjc,S., Mirkovic,B., Gobec,S., Lah,T., Sersa,G. and Kos,J. Addition of 2-(ethylamino)acetonitrile group to nitroxoline results in significantly improved anti-tumor activity in vitro and in vivo Oncotarget (2017) 8, 59136-59147. PubMed Europe PubMed DOI PMC EPMC I
Ngcungcu,T., Oti,M., Sitek,J.C., Haukanes,B.I., Linghu,B., Bruccoleri,R., Stokowy,T., Oakeley,E.J., Yang,F., Zhu,J., Sultan,M., Schalkwijk,J., van Vlijmen-Willems,I.M.J.J., von der Lippe,C., Brunner,H.G., Ersland,K.M., Grayson,W., Buechmann-Moller,S., Sundnes,O., Nirmala,N., Morgan,T.M., van Bokhoven,H., Steen,V.M., Hull,P.R., Szustakowski,J., Staedtler,F., Zhou,H., Fiskerstrand,T. and Ramsay,M. Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families Am J Hum Genet (2017) 100, 737-750. PubMed Europe PubMed DOI M
Oh,S.S., Park,S., Lee,K.W., Madhi,H., Park,S.G., Lee,H.G., Cho,Y.Y., Yoo,J. and Dong Kim,K. Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation Cell Death Dis (2017) 8, e2729-e2729. PubMed Europe PubMed DOI
Reinheckel,T. New kid on the block Theranostics (2017) 7, 2965-2967. PubMed Europe PubMed DOI PMC EPMC
Roth-Konforti,M.E., Bauer,C.R. and Shabat,D. Unprecedented sensitivity in a probe for monitoring cathepsin B: chemiluminescence microscopy cell-imaging of a natively expressed enzyme Angew Chem Int Ed Engl (2017) 56, 15633-15638. PubMed Europe PubMed DOI A L
Shoji,A., Suenaga,Y., Hosaka,A., Ishida,Y., Yanagida,A. and Sugawara,M. Inhibitory assay for degradation of collagen IV by cathepsin B with a surface plasmon resonance sensor J Pharm Biomed Anal (2017) 145, 79-83. PubMed Europe PubMed DOI I
Wu,Z., Ni,J., Liu,Y., Teeling,J.L., Takayama,F., Collcutt,A., Ibbett,P. and Nakanishi,H. Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice Brain Behav Immun (2017) 65, 350-361. PubMed Europe PubMed DOI I
Yang,K.M., Bae,E., Ahn,S.G., Pang,K., Park,Y., Park,J., Lee,J., Ooshima,A., Park,B., Kim,J., Jung,Y., Takahashi,S., Jeong,J., Park,S.H. and Kim,S.J. Co-chaperone BAG2 determines the pro-oncogenic role of cathepsin B in triple-negative breast cancer cells Cell Rep (2017) 21, 2952-2964. PubMed Europe PubMed DOI
Zhang,X., Yang,X., Wang,H., Li,S., Guo,K., Jiang,D., Xiao,J. and Liang,D. Design, synthesis, and structure-activity relationship study of epoxysuccinyl-peptide derivatives as cathepsin B inhibitors Biol Pharm Bull (2017) 40, 1240-1246. PubMed Europe PubMed DOI I

2016

Akkari,L., Gocheva,V., Quick,M.L., Kester,J.C., Spencer,A.K., Garfall,A.L., Bowman,R.L. and Joyce,J.A. Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer Genes Dev (2016) 30, 220-232. PubMed Europe PubMed DOI PMC EPMC K
Bian,B., Mongrain,S., Cagnol,S., Langlois,M.J., Boulanger,J., Bernatchez,G., Carrier,J.C., Boudreau,F. and Rivard,N. Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis Mol Carcinog (2016) 55, 671-687. PubMed Europe PubMed DOI
Castro-Gomes,T., Corrotte,M., Tam,C. and Andrews,N.W. Plasma membrane repair is regulated extracellularly by proteases released from lysosomes PLoS ONE (2016) 11, e0152583-e0152583. PubMed Europe PubMed DOI PMC EPMC
Coman,A.G., Paraschivescu,C.C., Hadade,N.D., Juncu,A., Vlaicu,O., Popescu,C.-I. and Matache,M. New acyloxymethyl ketones: useful probes for cysteine protease profiling Synthesis (2016) 48, 3917-3923. DOI I
Dai,L.S., Sun,Y., Sun,Y.X., Zhu,B.J. and Liu,C.L. Characterization and function of a cathepsin B in red crayfish (Procambarus clarkii) following lipopolysaccharide challenge Fish Shellfish Immunol (2016) 56, 162-168. PubMed Europe PubMed DOI
de Castro,M.A., Bunt,G. and Wouters,F.S. Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes Cell Death Discov (2016) 2, 16012-16012. PubMed Europe PubMed DOI PMC EPMC
Dinnes,D.L., White,M.Y., Kockx,M., Traini,M., Hsieh,V., Kim,M.J., Hou,L., Jessup,W., Rye,K.A., Thaysen-Andersen,M., Cordwell,S.J. and Kritharides,L. Human macrophage cathepsin B-mediated C-terminal cleavage of apolipoprotein A-I at Ser228 severely impairs antiatherogenic capacity FASEB J (2016) 30, 4239-4255. PubMed Europe PubMed DOI P
Fan,P.W., Zhang,D., Halladay,J.S., Driscoll,J.P. and Khojasteh,S.C. Going beyond common drug metabolizing enzymes: case studies of biotransformation involving aldehyde oxidase, gamma-glutamyl transpeptidase, cathepsin B, flavin-containing monooxygenase, and ADP-ribosyltransferase Drug Metab Dispos (2016) 44, 1253-1261. PubMed Europe PubMed DOI
Gikanga,B., Adeniji,N.S., Patapoff,T.W., Chih,H.W. and Yi,L. Cathepsin B cleavage of vcMMAE-based antibody-drug conjugate is not drug location or monoclonal antibody carrier specific Bioconjug Chem (2016) 27, 1040-1049. PubMed Europe PubMed DOI
Gomez-Auli,A., Hillebrand,L.E., Biniossek,M.L., Peters,C., Reinheckel,T. and Schilling,O. Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers Biochimie (2016) 122, 88-98. PubMed Europe PubMed DOI
Hingorani,D.V., Montano,L.A., Randtke,E.A., Lee,Y.S., Cardenas-Rodriguez,J. and Pagel,M.D. A single diamagnetic catalyCEST MRI contrast agent that detects cathepsin B enzyme activity by using a ratio of two CEST signals Contrast Media Mol Imaging (2016) 11, 130-138. PubMed Europe PubMed DOI L
Jiang,Y., Woosley,A.N., Sivalingam,N., Natarajan,S. and Howe,P.H. Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-beta-induced autophagy Nat Cell Biol (2016) 18, 851-863. PubMed Europe PubMed DOI
Kern,J.C., Dooney,D., Zhang,R., Liang,L., Brandish,P.E., Cheng,M., Feng,G., Beck,A., Bresson,D., Firdos,J., Gately,D., Knudsen,N., Manibusan,A., Sun,Y. and Garbaccio,R.M. Novel phosphate modified cathepsin B linkers: improving aqueous solubility and enhancing payload scope of ADCs Bioconjug Chem (2016) 27, 2081-2088. PubMed Europe PubMed DOI
Langdon,Y.G., Fuentes,R., Zhang,H., Abrams,E.W., Marlow,F.L. and Mullins,M.C. Split top: a maternal cathepsin B that regulates dorsoventral patterning and morphogenesis Development (2016) 143, 1016-1028. PubMed Europe PubMed DOI M
Man,S.M. and Kanneganti,T.D. Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B Autophagy (2016) 12, 2504-2505. PubMed Europe PubMed DOI
Mitrovic,A., Mirkovic,B., Sosic,I., Gobec,S. and Kos,J. Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion Biol Chem (2016) 397, 165-174. PubMed Europe PubMed DOI I
Mitrovic,A., Kljun,J., Sosic,I., Gobec,S., Turel,I. and Kos,J. Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity Dalton Trans (2016) 45, 16913-16921. PubMed Europe PubMed DOI I
Niemer,M., Mehofer,U., Verdianz,M., Porodko,A., Schahs,P., Kracher,D., Lenarcic,B., Novinec,M. and Mach,L. Nicotiana benthamiana cathepsin B displays distinct enzymatic features which differ from its human relative and aleurain-like protease Biochimie (2016) 122, 119-125. PubMed Europe PubMed DOI
Raghav,N., Jangra,S., Kumar,A., Bhattacharyya,S., Wadhwa,D. and Sindhu,J. Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones RSC Adv (2016) 6, 34588-34599. DOI I
Schmitz,J., Li,T., Bartz,U. and Gutschow,M. Cathepsin B inhibitors: combining dipeptide nitriles with an occluding loop recognition element by click chemistry ACS Med Chem Lett (2016) 7, 211-216. PubMed Europe PubMed DOI PMC EPMC I
Sendler,M., Maertin,S., John,D., Persike,M., Weiss,F.U., Kruger,B., Wartmann,T., Wagh,P., Halangk,W., Schaschke,N., Mayerle,J. and Lerch,M.M. Cathepsin B activity initiates apoptosis via digestive protease activation in pancreatic acinar cells and experimental pancreatitis J Biol Chem (2016) 291, 14717-14731. PubMed Europe PubMed DOI
Sigloch,F.C., Knopf,J.D., Weisser,J., Gomez-Auli,A., Biniossek,M.L., Petrera,A. and Schilling,O. Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality Biochim Biophys Acta (2016) 1863, 2700-2709. PubMed Europe PubMed DOI
Talukdar,R., Sareen,A., Zhu,H., Yuan,Z., Dixit,A., Cheema,H., George,J., Barlass,U., Sah,R., Garg,S.K., Banerjee,S., Garg,P., Dudeja,V., Dawra,R. and Saluja,A.K. Release of cathepsin B in cytosol causes cell death in acute pancreatitis Gastroenterology (2016) 151, 747-758. PubMed Europe PubMed DOI
Wang,Y., Li,J., Feng,L., Yu,J., Zhang,Y., Ye,D. and Chen,H.Y. Lysosome-targeting fluorogenic probe for cathepsin B imaging in living cells Anal Chem (2016) 88, 12403-12410. PubMed Europe PubMed DOI L
Withana,N.P., Garland,M., Verdoes,M., Ofori,L.O., Segal,E. and Bogyo,M. Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes Nat Protoc (2016) 11, 184-191. PubMed Europe PubMed DOI L
Withana,N.P., Ma,X., McGuire,H.M., Verdoes,M., van der Linden,W.A., Ofori,L.O., Zhang,R., Li,H., Sanman,L.E., Wei,K., Yao,S., Wu,P., Li,F., Huang,H., Xu,Z., Wolters,P.J., Rosen,G.D., Collard,H.R., Zhu,Z., Cheng,Z. and Bogyo,M. Non-invasive imaging of idiopathic pulmonary fibrosis using cathepsin protease probes Sci Rep (2016) 6, 19755-19755. PubMed Europe PubMed DOI PMC EPMC L
Wouters,F.S. and Bunt,G. Cathepsin B pulls the emergency brake on cellular necrosis Cell Death Dis (2016) 7, e2170-e2170. PubMed Europe PubMed DOI

2015

Ferrara,T.F., Schneider,V.K., Kishi,L.T., Carmona,A.K., Alves,M.F., Belasque-Junior,J., Rosa,J.C., Hunter,W.B., Henrique-Silva,F. and Soares-Costa,A. Characterization of a recombinant cathepsin B-Like cysteine peptidase from Diaphorina citri Kuwayama (Hemiptera: Liviidae): a putative target for control of citrus huanglongbing PLoS ONE (2015) 10, e0145132-e0145132. PubMed Europe PubMed DOI
Hook,G., Jacobsen,J.S., Grabstein,K., Kindy,M. and Hook,V. Cathepsin B is a new drug target for traumatic brain injury therapeutics: evidence for E64d as a promising lead drug candidate Front Neurol (2015) 6, 178-178. PubMed Europe PubMed DOI PMC EPMC I
Kedzior,M., Seredynski,R., Godzik,U., Tomczyk,D., Gutowicz,J., Terlecka,E., Calkosinski,I. and Terlecki,G. Inhibition of cathepsin B activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin Environ Sci Pollut Res Int (2015) 22, 733-737. PubMed Europe PubMed DOI I
Kim,S.H., Zhao,M.H., Liang,S., Cui,X.S. and Kim,N.H. Inhibition of cathepsin B activity reduces apoptosis by preventing cytochrome c release from mitochondria in porcine parthenotes J Reprod Dev (2015) 61, 261-268. PubMed Europe PubMed DOI I
McGlinchey,R.P. and Lee,J.C. Cysteine cathepsins are essential in lysosomal degradation of alpha-synuclein Proc Natl Acad Sci U S A (2015) 112, 9322-9327. PubMed Europe PubMed DOI P
Ni,J., Wu,Z., Peterts,C., Yamamoto,K., Qing,H. and Nakanishi,H. The critical role of proteolytic relay through cathepsins B and E in the phenotypic change of microglia/macrophage J Neurosci (2015) 35, 12488-12501. PubMed Europe PubMed DOI T
Ofori,L.O., Withana,N.P., Prestwood,T.R., Verdoes,M., Brady,J.J., Winslow,M.M., Sorger,J. and Bogyo,M. Design of protease activated optical contrast agents that exploit a latent lysosomotropic effect for use in fluorescence-guided surgery ACS Chem Biol (2015) 10, 1977-1988. PubMed Europe PubMed DOI L
Ogrizek,M., Turk,S., Lesnik,S., Sosic,I., Hodoscek,M., Mirkovic,B., Kos,J., Janezic,D., Gobec,S. and Konc,J. Molecular dynamics to enhance structure-based virtual screening on cathepsin B J Comput Aided Mol Des (2015) 29, 707-712. PubMed Europe PubMed DOI
Rajaram,K. and Nelson,D.E. Chlamydia muridarum infection of macrophages elicits bactericidal nitric oxide production via reactive oxygen species and cathepsin B Infect Immun (2015) 83, 3164-3175. PubMed Europe PubMed DOI
Ramalho,S.D., Sharma,R., White,J.K., Aggarwal,N., Chalasani,A., Sameni,M., Moin,K., Vieira,P.C., Turro,C., Kodanko,J.J. and Sloane,B.F. Imaging sites of inhibition of proteolysis in pathomimetic human breast cancer cultures by light-activated ruthenium compound PLoS ONE (2015) 10, e0142527-e0142527. PubMed Europe PubMed DOI PMC EPMC L
Ramalho,S.D., De Sousa,L.R., Burger,M.C., Lima,M.I., da Silva,M.F., Fernandes,J.B. and Vieira,P.C. Evaluation of flavonols and derivatives as human cathepsin B inhibitor Nat Prod Res (2015) 29, 2212-2214. PubMed Europe PubMed DOI I
Ruan,H., Hao,S., Young,P. and Zhang,H. Targeting cathepsin B for cancer therapies Horiz Cancer Res (2015) 56, 23-40. PubMed Europe PubMed PMC EPMC V U
Ruan,H., Hao,S., Young,P. and Zhang,H. Targeting cathepsin B for cancer therapies Horizons in Cancer Res (2015) 56, 23-39.
Sbongile,M. and Soliman,M.E. In silico identification of irreversible cathepsin B inhibitors as anti-cancer agents: virtual screening, covalent docking analysis and molecular dynamics simulations Comb Chem High Throughput Screen (2015) 18, 399-410. PubMed Europe PubMed I
Singh,M. and Raghav,N. 2,3-Dihydroquinazolin-4(1H)-one derivatives as potential non-peptidyl inhibitors of cathepsins B and H Bioorg Chem (2015) 59C, 12-22. PubMed Europe PubMed DOI I
Swisher,L.Z., Prior,A.M., Gunaratna,M.J., Shishido,S., Madiyar,F., Nguyen,T.A., Hua,D.H. and Li,J. Quantitative electrochemical detection of cathepsin B activity in breast cancer cell lysates using carbon nanofiber nanoelectrode arrays toward identification of cancer formation Nanomedicine (2015) 11, 1695-1704. PubMed Europe PubMed DOI A
Tsujimura,A., Taguchi,K., Watanabe,Y., Tatebe,H., Tokuda,T., Mizuno,T. and Tanaka,M. Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous alpha-synuclein fibrils Neurobiol Dis (2015) 73, 244-253. PubMed Europe PubMed DOI
Vizovisek,M., Vidmar,R., Van Quickelberghe,E., Impens,F., Andjelkovic,U., Sobotic,B., Stoka,V., Gevaert,K., Turk,B. and Fonovic,M. Fast profiling of protease specificity reveals similar substrate specificities for cathepsins K, L and S Proteomics (2015) 15, 2479-2490. PubMed Europe PubMed DOI P
Weber,E., Barbulescu,E., Medek,R., Reinheckel,T., Sameni,M., Anbalagan,A., Moin,K. and Sloane,B.F. Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies Biol Chem (2015) 396, 277-281. PubMed Europe PubMed DOI K
Wu,Q.Q., Xu,M., Yuan,Y., Li,F.F., Yang,Z., Liu,Y., Zhou,M.Q., Bian,Z.Y., Deng,W., Gao,L., Li,H. and Tang,Q.Z. Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-alpha/ASK1/JNK pathway Am J Physiol Heart Circ Physiol (2015) 308, H1143-H1154. PubMed Europe PubMed DOI
Xu,Z.Z., Xiu,P., Lv,J.W., Wang,F.H., Dong,X.F., Liu,F., Li,T. and Li,J. Integrin alphavbeta3 is required for cathepsin B-induced hepatocellular carcinoma progression Mol Med Rep (2015) 11, 3499-3504. PubMed Europe PubMed DOI
Yakovlev,A.A. and Gulyaeva,N.V. Possible role of proteases in preconditioning of brain cells to pathological conditions Biochemistry (Mosc) (2015) 80, 163-171. PubMed Europe PubMed DOI
Yhee,J.Y., Kim,Y.J., Ryu,J.H., Yoon,H.Y., Chang,H., Park,J.H., Lee,H., Jang,H.S., Jeong,U., Kim,K. and Kang,S.W. Cathepsin B imaging to predict quality of engineered cartilage Macromol Biosci (2015) 15, 1224-1232. PubMed Europe PubMed DOI L
Yoshida,A., Ohta,M., Kuwahara,K., Cao,M.J., Hara,K. and Osatomi,K. Purification and characterization of cathepsin B from the muscle of horse mackerel Trachurus japonicus Mar Drugs (2015) 13, 6550-6565. PubMed Europe PubMed DOI
Zenon,F., Cantres-Rosario,Y., Adiga,R., Gonzalez,M., Rodriguez-Franco,E., Langford,D. and Melendez,L.M. HIV-infected microglia mediate cathepsin B-induced neurotoxicity J Neurovirol (2015) 21, 544-558. PubMed Europe PubMed DOI
Zhou,Z.J., Qiu,R. and Zhang,J. Molecular characterization of the cathepsin B of turbot (Scophthalmus maximus) Fish Physiol Biochem (2015) 41, 473-483. PubMed Europe PubMed DOI
Zhu,W., Tao,L., Quick,M.L., Joyce,J.A., Qu,J.M. and Luo,Z.Q. Sensing cytosolic RpsL by macrophages induces lysosomal cell death and termination of bacterial infection PLoS Pathog (2015) 11, e1004704-e1004704. PubMed Europe PubMed DOI

2014

Aggarwal,N. and Sloane,B.F. Cathepsin B: multiple roles in cancer Proteomics Clin Appl (2014) 8, 427-437. PubMed Europe PubMed DOI V
Arockiaraj,J., Kumaresan,V., Chaurasia,M.K., Bhatt,P., Palanisamy,R., Pasupuleti,M., Gnanam,A.J. and Kasi,M. Molecular characterization of a novel cathepsin B from striped murrel Channa striatus: bioinformatics analysis, gene expression, synthesis of peptide and antimicrobial property Turk J Fish Aquat Sci (2014) 14, 379-389. DOI
Bengsch,F., Buck,A., Gunther,S.C., Seiz,J.R., Tacke,M., Pfeifer,D., von Elverfeldt,D., Sevenich,L., Hillebrand,L.E., Kern,U., Sameni,M., Peters,C., Sloane,B.F. and Reinheckel,T. Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression Oncogene (2014) 33, 4474-4484. PubMed Europe PubMed DOI
Che,R., Wang,R. and Xu,T. Comparative genomic of the teleost cathepsin B and H and involvement in bacterial induced immunity of miiuy croaker Fish Shellfish Immunol (2014) 41, 163-171. PubMed Europe PubMed DOI
Chen,T.P., Yang,S.F., Lin,C.W., Lee,H.L., Tsai,C.M. and Weng,C.J. A4383C and C76G SNP in cathepsin B is respectively associated with the high risk and tumor size of hepatocarcinoma Tumour Biol (2014) 35, 11193-11198. PubMed Europe PubMed DOI M
Chowdhury,M.A., Moya,I.A., Bhilocha,S., McMillan,C.C., Vigliarolo,B.G., Zehbe,I. and Phenix,C.P. Prodrug-inspired probes selective to cathepsin B over other cysteine cathepsins J Med Chem (2014) 57, 6092-6104. PubMed Europe PubMed DOI
de la Torre,C., Mondragon,L., Coll,C., Sancenon,F., Marcos,M.D., Martinez-Manez,R., Amoros,P., Perez-Paya,E. and Orzaez,M. Cathepsin-B induced controlled release from peptide-capped mesoporous silica nanoparticles Chemistry (2014) 20, 15309-15314. PubMed Europe PubMed DOI
Edem,P.E., Czorny,S. and Valliant,J.F. Synthesis and evaluation of radioiodinated acyloxymethyl ketones as activity-based probes for cathepsin B J Med Chem (2014) 57, 9564-9577. PubMed Europe PubMed DOI I
Hayashi,Y., Koga,Y., Zhang,X., Peters,C., Yanagawa,Y., Wu,Z., Yokoyama,T. and Nakanishi,H. Autophagy in superficial spinal dorsal horn accelerates the cathepsin B-dependent morphine antinociceptive tolerance Neuroscience (2014) 275, 384-394. PubMed Europe PubMed DOI
Hook,G., Yu,J., Toneff,T., Kindy,M. and Hook,V. Brain pyroglutamate amyloid-beta is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic J Alzheimers Dis (2014) 41, 129-149. PubMed Europe PubMed DOI I
Hook,G.R., Yu,J., Sipes,N., Pierschbacher,M.D., Hook,V. and Kindy,M.S. The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury J Neurotrauma (2014) 31, 515-529. PubMed Europe PubMed DOI T I
Kim,C.J., Lee,D.I., Kim,C., Lee,K., Lee,C.H. and Ahn,I.S. Gold Nanoparticles-Based Colorimetric Assay for Cathepsin B Activity and the Efficiency of Its Inhibitors Anal Chem (2014) 86, 3825-3833. PubMed Europe PubMed DOI A
Kisin-Finfer,E., Ferber,S., Blau,R., Satchi-Fainaro,R. and Shabat,D. Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action Bioorg Med Chem Lett (2014) 24, 2453-2458. PubMed Europe PubMed DOI A L
Kos,J., Mitrovic,A. and Mirkovic,B. The current stage of cathepsin B inhibitors as potential anticancer agents Future Med Chem (2014) 6, 1355-1371. PubMed Europe PubMed DOI I
Li,M., Li,Q., Yang,Z., Hu,G., Li,T., Chen,X. and Ao,J. Identification of cathepsin B from large yellow croaker (Pseudosciaena crocea) and its role in the processing of MHC class II-associated invariant chain Dev Comp Immunol (2014) 45, 313-320. PubMed Europe PubMed DOI
Mikhaylov,G., Klimpel,D., Schaschke,N., Mikac,U., Vizovisek,M., Fonovic,M., Turk,V., Turk,B. and Vasiljeva,O. Selective targeting of tumor and stromal cells by a nanocarrier system displaying lipidated cathepsin B inhibitor Angew Chem Int Ed Engl (2014) 53, 10077-10081. PubMed Europe PubMed DOI I
Raghav,N. and Kaur,R. Synthesis and evaluation of some semicarbazone- and thiosemicarbazone-based cathepsin B inhibitors Med Chem Res (2014) 23, 4669-4679. DOI I
Raghav,N. and Singh,M. Design, synthesis and docking studies of bischalcones based quinazoline-2(1H)-ones and quinazoline-2(1H)-thiones derivatives as novel inhibitors of cathepsin B and cathepsin H Eur J Pharm Sci (2014) 54, 28-39. PubMed Europe PubMed DOI I
Raghav,N. and Singh,M. Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H Eur J Med Chem (2014) 77, 231-242. PubMed Europe PubMed DOI I
Raghav,N. and Garg,S. SAR studies of o-hydroxychalcones and their cyclized analogs and study them as novel inhibitors of cathepsin B and cathepsin H Eur J Pharm Sci (2014) 60, 55-63. PubMed Europe PubMed DOI I
Raghav,N. and Singh,M. SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H Bioorg Med Chem (2014) 22, 4233-4245. PubMed Europe PubMed DOI I
Ravish,I. and Raghav,N. Curcumin as inhibitor of mammalian cathepsin B, cathepsin H, acid phosphatase and alkaline phosphatase: a correlation with pharmacological activities Med Chem Res (2014) 23, 2847-2855. DOI I
Rivera,L.E., Colon,K., Cantres-Rosario,Y.M., Zenon,F.M. and Melendez,L.M. Macrophage derived cystatin B/cathepsin B in HIV replication and neuropathogenesis Curr HIV Res (2014) 12, 111-120. PubMed Europe PubMed DOI
Ryu,J.H., Na,J.H., Ko,H.K., You,D.G., Park,S., Jun,E., Yeom,H.J., Seo,D.H., Park,J.H., Jeong,S.Y., Kim,I.S., Kim,B.S., Kwon,I.C., Choi,K. and Kim,K. Non-invasive optical imaging of cathepsin B with activatable fluorogenic nanoprobes in various metastatic models Biomaterials (2014) 35, 2302-2311. PubMed Europe PubMed DOI L
Shoji,A., Kabeya,M., Ishida,Y., Yanagida,A., Shibusawa,Y. and Sugawara,M. Evaluation of cathepsin B activity for degrading collagen IV using a surface plasmon resonance method and circular dichroism spectroscopy J Pharm Biomed Anal (2014) 95, 47-53. PubMed Europe PubMed DOI
Swisher,L.Z., Prior,A.M., Shishido,S., Nguyen,T.A., Hua,D.H. and Li,J. Quantitative electrochemical detection of cathepsin B activity in complex tissue lysates using enhanced AC voltammetry at carbon nanofiber nanoelectrode arrays Biosens Bioelectron (2014) 56, 129-136. PubMed Europe PubMed DOI A
Tan,C.D., Hobbs,C., Sameni,M., Sloane,B.F., Stutts,M.J. and Tarran,R. Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures J Physiol (2014) 592, 5251-5268. PubMed Europe PubMed DOI
Tholen,S., Biniossek,M.L., Gansz,M., Ahrens,T.D., Schlimpert,M., Kizhakkedathu,J.N., Reinheckel,T. and Schilling,O. Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis Cell Mol Life Sci (2014) 71, 899-916. PubMed Europe PubMed DOI K
Tong,B., Wan,B., Wei,Z., Wang,T., Zhao,P., Dou,Y., Lv,Z., Xia,Y. and Dai,Y. Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis Clin Exp Immunol (2014) 177, 586-597. PubMed Europe PubMed DOI I
Toomey,C.B., Cauvi,D.M., Hamel,J.C., Ramirez,A.E. and Pollard,K.M. Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity Toxicol Sci (2014) 142, 339-349. PubMed Europe PubMed DOI
van der Meer,L.T., Waanders,E., Levers,M., Venselaar,H., Roeleveld,D., Boos,J., Lanvers,C., Bruggemann,R.J., Kuiper,R.P., Hoogerbrugge,P.M., van Leeuwen,F.N. and te Loo,D.M. A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics Blood (2014) 124, 3027-3029. PubMed Europe PubMed DOI M
Vega-Teijido,M.A., El Chamy Maluf,S., Bonturi,C.R., Sambrano,J.R. and Ventura,O.N. Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin B by 1,2,4-thiadiazole derivatives J Mol Model (2014) 20, 2254-2254. PubMed Europe PubMed DOI I
Wei,S., Huang,Y., Huang,X., Cai,J., Yan,Y., Guo,C. and Qin,Q. Characterization of cathepsin B gene from orange-spotted grouper, Epinephelus coioides involved in SGIV infection Fish Shellfish Immunol (2014) 36, 194-205. PubMed Europe PubMed DOI
Zhang,T., Jia,L.F., Chen,Y., Ju,C., Mo,X.J., Xu,B., Chen,S.B., Chen,J.H. and Hu,W. [Cloning, expression and bioinformatics analysis of cathepsin B of Echinococcus granulosus] Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi (2014) 26, 642-647. PubMed Europe PubMed

2013

Baek,K.H., Karki,R., Lee,E.S., Na,Y. and Kwon,Y. Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors Bioorg Chem (2013) 51, 24-30. PubMed Europe PubMed DOI I
Balboula,A.Z., Yamanaka,K., Sakatani,M., Kawahara,M., Hegab,A.O., Zaabel,S.M. and Takahashi,M. Cathepsin B activity has a crucial role in the developmental competence of bovine cumulus-oocyte complexes exposed to heat shock during in vitro maturation Reproduction (2013) 146, 407-417. PubMed Europe PubMed DOI I
Bao,W., Fan,Q., Luo,X., Cheng,W.W., Wang,Y.D., Li,Z.N., Chen,X.L. and Wu,D. Silencing of cathepsin B suppresses the proliferation and invasion of endometrial cancer Oncol Rep (2013) 30, 723-730. PubMed Europe PubMed DOI K
Buhler,A., Berger,S., Bengsch,F., Martin,G., Han,H., Vierkotten,S., Pielen,A., Boehringer,D., Schlunck,G., Fauser,S., Agostini,H.T., Reinheckel,T. and Stahl,A. Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice Exp Eye Res (2013) 115, 73-78. PubMed Europe PubMed DOI K
Dev,A., Byrne,S.M., Verma,R., Ashton-Rickardt,P.G. and Wojchowski,D.M. Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins J Exp Med (2013) 210, 225-232. PubMed Europe PubMed DOI
Gondi,C.S. and Rao,J.S. Cathepsin B as a cancer target Expert Opin Ther Targets (2013) 17, 281-291. PubMed Europe PubMed DOI V
Kim,C.J., Lee,D.I., Zhang,D., Lee,C.H. and Ahn,I.S. New strategy for selective and sensitive assay of cathepsin B using a dityrosine-based material Anal Biochem (2013) 435, 166-173. PubMed Europe PubMed DOI A
Morchang,A., Panaampon,J., Suttitheptumrong,A., Yasamut,U., Noisakran,S., Yenchitsomanus,P.T. and Limjindaporn,T. Role of cathepsin B in dengue virus-mediated apoptosis Biochem Biophys Res Commun (2013) 438, 20-25. PubMed Europe PubMed DOI
Niu,D., Jin,K., Wang,L., Sun,F. and Li,J. Identification of cathepsin B in the razor clam Sinonovacula constricta and its role in innate immune responses Dev Comp Immunol (2013) 41, 94-99. PubMed Europe PubMed DOI
Qiu,R., Liu,X., Hu,Y.H. and Sun,B.G. Expression characterization and activity analysis of a cathepsin B from Pacific abalone Haliotis discus hannai Fish Shellfish Immunol (2013) 34, 1376-1382. PubMed Europe PubMed DOI
Rao Malla,R., Gopinath,S., Alapati,K., Gorantla,B., Gondi,C.S. and Rao,J.S. Knockdown of cathepsin B and uPAR inhibits CD151 and alpha3beta1 integrin-mediated cell adhesion and invasion in glioma Mol Carcinog (2013) 52, 777-790. PubMed Europe PubMed DOI K
Rothberg,J.M., Bailey,K.M., Wojtkowiak,J.W., Ben-Nun,Y., Bogyo,M., Weber,E., Moin,K., Blum,G., Mattingly,R.R., Gillies,R.J. and Sloane,B.F. Acid-mediated tumor proteolysis: Contribution of cysteine cathepsins Neoplasia (2013) 15, 1125-1137. PubMed Europe PubMed DOI
Sosic,I., Mirkovic,B., Arenz,K., Stefane,B., Kos,J. and Gobec,S. Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives J Med Chem (2013) 56, 521-533. PubMed Europe PubMed DOI I
Tholen,S., Biniossek,M.L., Gansz,M., Gomez-Auli,A., Bengsch,F., Noel,A., Kizhakkedathu,J.N., Boerries,M., Busch,H., Reinheckel,T. and Schilling,O. Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome Mol Cell Proteomics (2013) 12, 611-625. PubMed Europe PubMed DOI K
Zhong,Y.J., Shao,L.H. and Li,Y. Cathepsin B-cleavable doxorubicin prodrugs for targeted cancer therapy (Review) Int J Oncol (2013) 42, 373-383. PubMed Europe PubMed DOI

2012

Alli,A.A., Song,J.Z., Al-Khalili,O., Bao,H.F., Ma,H.P., Alli,A.A. and Eaton,D.C. Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity J Biol Chem (2012) 287, 30073-30083. PubMed Europe PubMed DOI
Beckham,T.H., Lu,P., Cheng,J.C., Zhao,D., Turner,L.S., Zhang,X., Hoffman,S., Armeson,K.E., Liu,A., Marrison,T., Hannun,Y.A. and Liu,X. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B Int J Cancer (2012) 131, 2034-2043. PubMed Europe PubMed DOI
Byrne,S.M., Aucher,A., Alyahya,S., Elder,M., Olson,S.T., Davis,D.M. and Ashton-Rickardt,P.G. Cathepsin B controls the persistence of memory CD8+ T lymphocytes J Immunol (2012) 189, 1133-1143. PubMed Europe PubMed DOI
Chen,L. and Sun,L. Cathepsin B of Cynoglossus semilaevis: identification, expression, and activity analysis Comp Biochem Physiol B Biochem Mol Biol (2012) 161, 54-59. PubMed Europe PubMed DOI
Chen,W.N., Chen,J.Y., Jiao,B.Y., Lin,W.S., Wu,Y.L., Liu,L.L. and Lin,X. Interaction of the hepatitis B spliced protein with cathepsin B promotes hepatoma cell migration and invasion J Virol (2012) 86, 13533-13541. PubMed Europe PubMed DOI
Chu,D.S., Johnson,R.N. and Pun,S.H. Cathepsin B-sensitive polymers for compartment-specific degradation and nucleic acid release J Control Release (2012) 157, 445-454. PubMed Europe PubMed DOI
Colletti,G.A., Miedel,M.T., Quinn,J., Andharia,N., Weisz,O.A. and Kiselyov,K. Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosis J Biol Chem (2012) 287, 8082-8091. PubMed Europe PubMed DOI T
Diederich,S., Sauerhering,L., Weis,M., Altmeppen,H., Schaschke,N., Reinheckel,T., Erbar,S. and Maisner,A. Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosome-recycling compartment J Virol (2012) 86, 3736-3745. PubMed Europe PubMed DOI
Gnirss,K., Kuhl,A., Karsten,C., Glowacka,I., Bertram,S., Kaup,F., Hofmann,H. and Pohlmann,S. Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression Virology (2012) 424, 3-10. PubMed Europe PubMed DOI
Gopinathan,A., Denicola,G.M., Frese,K.K., Cook,N., Karreth,F.A., Mayerle,J., Lerch,M.M., Reinheckel,T. and Tuveson,D.A. Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice Gut (2012) 61, 877-884. PubMed Europe PubMed DOI
Gornicka,A., Fettig,J., Eguchi,A., Berk,M.P., Thapaliya,S., Dixon,L.J. and Feldstein,A.E. Adipocyte hypertrophy is associated with lysosomal permeability both in vivo and in vitro: role in adipose tissue inflammation Am J Physiol Endocrinol Metab (2012) 303, E597-E606. PubMed Europe PubMed DOI
Guo,X. and Dhodapkar,K.M. Central and overlapping role of cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells Hum Immunol (2012) 73, 871-878. PubMed Europe PubMed DOI
Ha,S.D., Park,S., Hattlmann,C.J., Barr,S.D. and Kim,S.O. Inhibition or deficiency of cathepsin B leads defects in HIV-1 Gag pseudoparticle release in macrophages and HEK293T cells Antiviral Res (2012) 93, 175-184. PubMed Europe PubMed DOI I
Hook,V., Funkelstein,L., Wegrzyn,J., Bark,S., Kindy,M. and Hook,G. Cysteine cathepsins in the secretory vesicle produce active peptides: cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease Biochim Biophys Acta (2012) 1824, 89-104. PubMed Europe PubMed DOI
Kindy,M.S., Yu,J., Zhu,H., El-Amouri,S.S., Hook,V. and Hook,G.R. Deletion of the cathepsin B gene improves memory deficits in a transgenic Alzheimer's disease mouse model expressing AbetaPP containing the wild-type beta-secretase site sequence J Alzheimers Dis (2012) 29, 827-840. PubMed Europe PubMed DOI K
Kong,L. and Zhou,G.H. Cathepsin B-RNAi-lentivirus inhibitis capillary-like tube formation in vitro Acta Anat Sin (2012) 43, 377-380. DOI K
Liang,L., Lin,S.W., Dai,W., Lu,J.K., Yang,T.Y., Xiang,Y., Zhang,Y., Li,R.T. and Zhang,Q. Novel cathepsin B-sensitive paclitaxel conjugate: higher water solubility, better efficacy and lower toxicity J Control Release (2012) 160, 618-629. PubMed Europe PubMed DOI
Misasi,J., Chandran,K., Yang,J.Y., Considine,B., Filone,C.M., Cote,M., Sullivan,N., Fabozzi,G., Hensley,L. and Cunningham,J. Filoviruses require endosomal cysteine proteases for entry but exhibit distinct protease preferences J Virol (2012) 86, 3284-3292. PubMed Europe PubMed DOI
Mort,J.S. Cathepsin B [ISSN:978-0-12-407743-0] (2012) 3, 1784-1791. DOI
Orlichenko,L., Stolz,D.B., Noel,P., Behari,J., Liu,S. and Singh,V.P. ADP-ribosylation factor 1 protein regulates trypsinogen activation via organellar trafficking of procathepsin B protein and autophagic maturation in acute pancreatitis J Biol Chem (2012) 287, 24284-24293. PubMed Europe PubMed DOI
Reinheckel,T., Peters,C., Kruger,A., Turk,B. and Vasiljeva,O. Differential impact of cysteine cathepsins on genetic mouse models of de novo carcinogenesis: cathepsin B as emerging therapeutic target Front Pharmacol (2012) 3, 133-133. PubMed Europe PubMed DOI PMC EPMC T
Shi,C., Zheng,D.D., Wu,F.M., Liu,J. and Xu,J. The phosphatidyl inositol 3 kinase-glycogen synthase kinase 3beta pathway mediates bilobalide-induced reduction in amyloid beta-peptide Neurochem Res (2012) 37, 298-306. PubMed Europe PubMed DOI
Siricoon,S., Grams,S.V. and Grams,R. Efficient inhibition of cathepsin B by a secreted type 1 cystatin of Fasciola gigantica Mol Biochem Parasitol (2012) 186, 126-133. PubMed Europe PubMed DOI
Stephens,A., Rojo,L., Araujo-Bernal,S., Garcia-Carreno,F. and Muhlia-Almazan,A. Cathepsin B from the white shrimp Litopenaeus vannamei: cDNA sequence analysis, tissues-specific expression and biological activity Comp Biochem Physiol B Biochem Mol Biol (2012) 161, 32-40. PubMed Europe PubMed DOI
Sun,L., Wu,Z., Hayashi,Y., Peters,C., Tsuda,M., Inoue,K. and Nakanishi,H. Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain J Neurosci (2012) 32, 11330-11342. PubMed Europe PubMed DOI
Wang,C., Sun,B., Zhou,Y., Grubb,A. and Gan,L. Cathepsin B degrades amyloid-beta in mice expressing wild-type human amyloid precursor protein J Biol Chem (2012) 287, 39834-39841. PubMed Europe PubMed DOI
Withana,N.P., Blum,G., Sameni,M., Slaney,C., Anbalagan,A., Olive,M.B., Bidwell,B.N., Edgington,L., Wang,L., Moin,K., Sloane,B.F., Anderson,R.L., Bogyo,M.S. and Parker,B.S. Cathepsin B inhibition limits bone metastasis in breast cancer Cancer Res (2012) 72, 1199-1209. PubMed Europe PubMed DOI I

2011

Asai,M., Yagishita,S., Iwata,N., Saido,T.C., Ishiura,S. and Maruyama,K. An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model FASEB J (2011) 25, 3720-3730. PubMed Europe PubMed DOI I
Baudy,A.R., Sali,A., Jordan,S., Kesari,A., Johnston,H.K., Hoffman,E.P. and Nagaraju,K. Non-invasive optical imaging of muscle pathology in mdx mice using cathepsin caged near-infrared imaging Mol Imaging Biol (2011) 13, 462-470. PubMed Europe PubMed DOI L
Biniossek,M.L., Nagler,D.K., Becker-Pauly,C. and Schilling,O. Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S J Proteome Res (2011) 10, 5363-5373. PubMed Europe PubMed DOI P
Czibere,L., Baur,L.A., Wittmann,A., Gemmeke,K., Steiner,A., Weber,P., Putz,B., Ahmad,N., Bunck,M., Graf,C., Widner,R., Kuhne,C., Panhuysen,M., Hambsch,B., Rieder,G., Reinheckel,T., Peters,C., Holsboer,F., Landgraf,R. and Deussing,J.M. Profiling trait anxiety: transcriptome analysis reveals cathepsin B (ctsb) as a novel candidate gene for emotionality in mice PLoS ONE (2011) 6, e23604-e23604. PubMed Europe PubMed DOI PMC EPMC T
Dai,C., Fu,Y., Li,B., Wang,Y., Zhang,X., Wang,J. and Zhang,Q. Linkage with cathepsin B-sensitive dipeptide promotes the in vitro and in vivo anticancer activity of PEGylated tumor necrosis factor-alpha (TNF-alpha) against murine fibrosarcoma Sci China Life Sci (2011) 54, 128-138. PubMed Europe PubMed DOI
Fustero,S., Rodrigo,V., Sanchez-Rosello,M., Del Pozo,C., Timoneda,J., Frizler,M., Sisay,M.T., Bajorath,J., Calle,L.P., Canada,F.J., Jimenez-Barbero,J. and Gutschow,M. New cathepsin inhibitors to explore the fluorophilic properties of the S2 pocket of cathepsin B: design, synthesis, and biological evaluation Chemistry (2011) 17, 5256-5260. PubMed Europe PubMed DOI I
Girotti,M.R., Fernandez,M., Lopez,J.A., Camafeita,E., Fernandez,E.A., Albar,J.P., Benedetti,L.G., Valacco,M.P., Brekken,R.A., Podhajcer,O.L. and Llera,A.S. SPARC promotes cathepsin B-mediated melanoma invasiveness through a collagen i/alpha2Beta1 integrin axis J Invest Dermatol (2011) 131, 2438-2447. PubMed Europe PubMed DOI
Le,Q.T., Min,H.K., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B. Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C J Immunol (2011) 186, 7136-7143. PubMed Europe PubMed DOI
Liang,Q., Ouyang,X., Schneider,L. and Zhang,J. Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons Mol Neurodegener (2011) 6, 37-37. PubMed Europe PubMed DOI U
Mirkovic,B., Renko,M., Turk,S., Sosic,I., Jevnikar,Z., Obermajer,N., Turk,D., Gobec,S. and Kos,J. Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds ChemMedChem (2011) 6, 1351-1356. PubMed Europe PubMed DOI I
Murayama,S., Imae,Y., Takada,K., Kikuchi,J., Nakao,Y., Van Soest,R.W., Okada,S. and Matsunaga,S. Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata Bioorg Med Chem (2011) 19, 6594-6598. PubMed Europe PubMed DOI I
Ryu,J.H., Kim,S.A., Koo,H., Yhee,J.Y., Lee,A., Na,J.H., Youn,I., Choi,K., Kwon,I.C., Kim,B.S. and Kim,K. Cathepsin B-sensitive nanoprobe for in vivo tumor diagnosis J Mater Chem (2011) 21, 17631-17634. DOI L
Sako,Y., Nakaya,K. and Ito,A. Echinococcus multilocularis: identification and functional characterization of cathepsin B-like peptidases from metacestode Exp Parasitol (2011) 127, 693-701. PubMed Europe PubMed DOI
Schechter,I. and Ziv,E. Cathepsins S, B and L with aminopeptidases display beta-secretase activity associated with the pathogenesis of Alzheimer's disease Biol Chem (2011) 392, 555-569. PubMed Europe PubMed DOI
Sevenich,L., Werner,F., Gajda,M., Schurigt,U., Sieber,C., Muller,S., Follo,M., Peters,C. and Reinheckel,T. Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice Oncogene (2011) 30, 54-64. PubMed Europe PubMed DOI
Sojka,D., Francischetti,I.M., Calvo,E. and Kotsyfakis,M. Cysteine proteases from bloodfeeding arthropod ectoparasites Adv Exp Med Biol (2011) 712, 177-191. PubMed Europe PubMed DOI
Sosic,I., Mirkovic,B., Turk,S., Stefane,B., Kos,J. and Gobec,S. Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B Eur J Med Chem (2011) 46, 4648-4656. PubMed Europe PubMed DOI I
Victor,B.C., Anbalagan,A., Mostafa Mohamed,M., Sloane,B.F. and Cavallo-Medved,D. Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion Breast Cancer Res (2011) 13, R115-R115. PubMed Europe PubMed DOI I
Wang,X., Liu,B., Tang,B. and Xiang,J. Potential role of cathepsin B in the embryonic and larval development of clam Meretrix meretrix J Exp Zool B Mol Dev Evol (2011) 316, 306-312. PubMed Europe PubMed DOI I
Whang,I., De Zoysa,M., Nikapitiya,C., Lee,Y., Kim,Y., Lee,S., Oh,C., Jung,S.J., Oh,M.J., Choi,C.Y., Yeo,S.Y., Kim,B.S., Kim,S.J. and Lee,J. Molecular characterization and expression analysis of cathepsin B and L cysteine proteases from rock bream (Oplegnathus fasciatus) Fish Shellfish Immunol (2011) 30, 763-772. PubMed Europe PubMed DOI
Wisastra,R., Ghizzoni,M., Maarsingh,H., Minnaard,A.J., Haisma,H.J. and Dekker,F.J. Isothiazolones; thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF Org Biomol Chem (2011) 9, 1817-1822. PubMed Europe PubMed DOI I
Yao,X., Zhang,J., Sun,J. and Liu,B. Recombinant expression, characterization and expressional analysis of clam Meretrix meretrix cathepsin B, an enzyme involved in nutrient digestion Mol Biol Rep (2011) 38, 1861-1868. PubMed Europe PubMed DOI
Zhang,T., Yang,Z.Y., Bo,X.P., Wu,X.Q., Li,Z.B. and Guo,S.X. [Cathepsin B promoted the apoptosis of vascular smooth muscle cells as induced by tumor necrosis factor-alpha] Zhonghua Yi Xue Za Zhi (2011) 91, 845-849. PubMed Europe PubMed
Zhou,Z., Wang,Y. and Bryant,S.H. Multi-conformation 3D QSAR study of benzenesulfonyl-pyrazol-ester compounds and their analogs as cathepsin B inhibitors J Mol Graph Model (2011) 30, 135-147. PubMed Europe PubMed DOI I
Zhu,Y., Cameron,B.R., Mosi,R., Anastassov,V., Cox,J., Qin,L., Santucci,Z., Metz,M., Skerlj,R.T. and Fricker,S.P. Inhibition of the cathepsin cysteine proteases B and K by square-planar cycloaurated gold(III) compounds and investigation of their anti-cancer activity J Inorg Biochem (2011) 105, 754-762. PubMed Europe PubMed DOI I

2010

Balboula,A.Z., Yamanaka,K., Sakatani,M., Hegab,A.O., Zaabel,S.M. and Takahashi,M. Cathepsin B activity is related to the quality of bovine cumulus oocyte complexes and its inhibition can improve their developmental competence Mol Reprod Dev (2010) 77, 439-448. PubMed Europe PubMed DOI
Bien,S., Rimmbach,C., Neumann,H., Niessen,J., Reimer,E., Ritter,C.A., Rosskopf,D., Cinatl,J., Michaelis,M., Schroeder,H.W. and Kroemer,H.K. Doxorubicin-induced cell death requires cathepsin B in HeLa cells Biochem Pharmacol (2010) 80, 1466-1477. PubMed Europe PubMed DOI I
Chan,A.T., Baba,Y., Shima,K., Nosho,K., Chung,D.C., Hung,K.E., Mahmood,U., Madden,K., Poss,K., Ranieri,A., Shue,D., Kucherlapati,R., Fuchs,C.S. and Ogino,S. Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasia Cancer Epidemiol Biomarkers Prev (2010) 19, 2777-2785. PubMed Europe PubMed DOI
Costa,M.G., Batista,P.R., Shida,C.S., Robert,C.H., Bisch,P.M. and Pascutti,P.G. How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamics BMC Genomics (2010) 11 Suppl 5, S5-S5. PubMed Europe PubMed DOI
Cunningham,E., McCarthy,E., Copley,L., Jackson,D., Johnson,D., Dalton,J.P. and Mulcahy,G. Characterisation of cathepsin B-like cysteine protease of Lepeophtheirus salmonis Aquaculture (2010) 310, 38-42. DOI
Eykelbosh,A.J. and Van Der Kraak,G. A role for the lysosomal protease cathepsin B in zebrafish follicular apoptosis Comp Biochem Physiol A Mol Integr Physiol (2010) 156, 218-223. PubMed Europe PubMed DOI I
Frizler,M., Stirnberg,M., Sisay,M.T. and Gutschow,M. Development of nitrile-based peptidic inhibitors of cysteine cathepsins Curr Top Med Chem (2010) 10, 294-322. PubMed Europe PubMed DOI T I
Gross,K.W., Gomez,R.A. and Sigmund,C.D. Twists and turns in the search for the elusive renin processing enzyme: focus on "Cathepsin B is not the processing enzyme for mouse prorenin" Am J Physiol Regul Integr Comp Physiol (2010) 298, R1209-R1211. PubMed Europe PubMed DOI
Ha,S.D., Ham,B., Mogridge,J., Saftig,P., Lin,S. and Kim,S.O. Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm J Biol Chem (2010) 285, 2120-2129. PubMed Europe PubMed DOI
Hook,V., Hook,G. and Kindy,M. Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease Biol Chem (2010) 391, 861-872. PubMed Europe PubMed DOI
Luo,C.L., Chen,X.P., Yang,R., Sun,Y.X., Li,Q.Q., Bao,H.J., Cao,Q.Q., Ni,H., Qin,Z.H. and Tao,L.Y. Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway J Neurosci Res (2010) 88, 2847-2858. PubMed Europe PubMed DOI I
Matarrese,P., Ascione,B., Ciarlo,L., Vona,R., Leonetti,C., Scarsella,M., Mileo,A.M., Catricala',C., Paggi,M.G. and Malorni,W. Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study Mol Cancer (2010) 9, 207-207. PubMed Europe PubMed DOI I
Meister,T., Niehues,R., Hahn,D., Domschke,W., Sendler,M., Lerch,M.M. and Schnekenburger,J. Missorting of cathepsin B into the secretory compartment of CI-MPR/IGFII-deficient mice does not induce spontaneous trypsinogen activation but leads to enhanced trypsin activity during experimental pancreatitis - without affecting disease severity J Physiol Pharmacol (2010) 61, 565-575. PubMed Europe PubMed
Mercure,C., Lacombe,M.J., Khazaie,K. and Reudelhuber,T.L. Cathepsin B is not the processing enzyme for mouse prorenin Am J Physiol Regul Integr Comp Physiol (2010) 298, R1212-R1216. PubMed Europe PubMed DOI K
Naudin,C., Lecaille,F., Chowdhury,S., Krupa,J.C., Purisima,E., Mort,J.S. and Lalmanach,G. The occluding loop of cathepsin B prevents its effective inhibition by human kininogens J Mol Biol (2010) 400, 1022-1035. PubMed Europe PubMed DOI
Percival,M.D., Toulmond,S., Coulombe,N., Cromlish,W., Desmarais,S., Liu,S., St-Jacques,R., Gauthier,J.Y. and Fournier,J.F. Pharmacological and genetic evidence that cathepsin B is not the physiological activator of rodent prorenin Biol Chem (2010) 391, 1469-1473. PubMed Europe PubMed DOI I
Renko,M., Pozgan,U., Majera,D. and Turk,D. Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft FEBS J (2010) 277, 4338-4345. PubMed Europe PubMed DOI S
Sevenich,L., Schurigt,U., Sachse,K., Gajda,M., Werner,F., Muller,S., Vasiljeva,O., Schwinde,A., Klemm,N., Deussing,J., Peters,C. and Reinheckel,T. Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice Proc Natl Acad Sci U S A (2010) 107, 2497-2502. PubMed Europe PubMed DOI K
Sun,L., Wu,Z., Baba,M., Peters,C., Uchiyama,Y. and Nakanishi,H. Cathepsin B-dependent motor neuron death after nerve injury in the adult mouse Biochem Biophys Res Commun (2010) 399, 391-395. PubMed Europe PubMed DOI
Tedelind,S., Poliakova,K., Valeta,A., Hunegnaw,R., Yemanaberhan,E.L., Heldin,N.E., Kurebayashi,J., Weber,E., Kopitar-Jerala,N., Turk,B., Bogyo,M. and Brix,K. Nuclear cysteine cathepsin variants in thyroid carcinoma cells Biol Chem (2010) 391, 923-935. PubMed Europe PubMed DOI
Tomoo,K. Development of cathepsin inhibitors and structure-based design of cathepsin B-specific inhibitor Curr Top Med Chem (2010) 10, 696-707. PubMed Europe PubMed DOI V I
Valadares,N.F., Dellamano,M., Soares-Costa,A., Henrique-Silva,F. and Garratt,R.C. Molecular determinants of improved cathepsin B inhibition by new cystatins obtained by DNA shuffling BMC Struct Biol (2010) 10, 30-30. PubMed Europe PubMed DOI E
Wong,A.C., Sandesara,R.G., Mulherkar,N., Whelan,S.P. and Chandran,K. A forward genetic strategy reveals destabilizing mutations in the ebolavirus glycoprotein that alter its protease dependence during cell entry J Virol (2010) 84, 163-175. PubMed Europe PubMed DOI
Zhou,Z., Wang,Y. and Bryant,S.H. QSAR models for predicting cathepsin B inhibition by small molecules - continuous and binary QSAR models to classify cathepsin B inhibition activities of small molecules J Mol Graph Model (2010) 28, 714-727. PubMed Europe PubMed DOI I

2009

Bethel,P.A., Gerhardt,S., Jones,E.V., Kenny,P.W., Karoutchi,G.I., Morley,A.D., Oldham,K., Rankine,N., Augustin,M., Krapp,S., Simader,H. and Steinbacher,S. Design of selective cathepsin inhibitors Bioorg Med Chem Lett (2009) 19, 4622-4625. PubMed Europe PubMed DOI I
Caglic,D., Kosec,G., Bojic,L., Reinheckel,T., Turk,V. and Turk,B. Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery Biol Chem (2009) 390, 175-179. PubMed Europe PubMed DOI T
Cavallo-Medved,D., Rudy,D., Blum,G., Bogyo,M., Caglic,D. and Sloane,B.F. Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation Exp Cell Res (2009) 315, 1234-1246. PubMed Europe PubMed DOI PMC EPMC L
Dabydeen,S.A. and Meneses,P.I. The role of NH4Cl and cysteine proteases in human papillomavirus type 16 infection Virol J (2009) 6, 109-109. PubMed Europe PubMed DOI PMC EPMC
Hook,V.Y., Kindy,M., Reinheckel,T., Peters,C. and Hook,G. Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein Biochem Biophys Res Commun (2009) 386, 284-288. PubMed Europe PubMed DOI PMC EPMC T
Jayashankar,L., Syama Sundar,B., Awasthi,S. and Madhulika,B. Analog based studies on cathepsin B inhibitors to design novel lead compounds for the treatment of cancer Internet Electron J Mol Des (2009) 8, 29-41. I
Jordans,S., Jenko-Kokalj,S., Kuhl,N.M., Tedelind,S., Sendt,W., Bromme,D., Turk,D. and Brix,K. Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions BMC Biochem (2009) 10, 23-23. PubMed Europe PubMed DOI PMC EPMC
Kim,D.E., Kim,J.Y., Schellingerhout,D., Shon,S.M., Jeong,S.W., Kim,E.J. and Kim,W.K. Molecular imaging of cathepsin B proteolytic enzyme activity reflects the inflammatory component of atherosclerotic pathology and can quantitatively demonstrate the antiatherosclerotic therapeutic effects of atorvastatin and glucosamine Mol Imaging (2009) 8, 291-301. PubMed Europe PubMed DOI L
Lee,K.S., Kim,B.Y., Choo,Y.M., Yoon,H.J., Kang,P.D., Woo,S.D., Sohn,H.D., Roh,J.Y., Gui,Z.Z., Je,Y.H. and Jin,B.R. Expression profile of cathepsin B in the fat body of Bombyx mori during metamorphosis Comp Biochem Physiol B Biochem Mol Biol (2009) 154, 188-194. PubMed Europe PubMed DOI
Mirkovic,B., Premzl,A., Hodnik,V., Doljak,B., Jevnikar,Z., Anderluh,G. and Kos,J. Regulation of cathepsin B activity by 2A2 monoclonal antibody FEBS J (2009) 276, 4739-4751. PubMed Europe PubMed DOI
Pratt,M.R., Sekedat,M.D., Chiang,K.P. and Muir,T.W. Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe Chem Biol (2009) 16, 1001-1012. PubMed Europe PubMed DOI L
Pungercar,J.R., Caglic,D., Sajid,M., Dolinar,M., Vasiljeva,O., Pozgan,U., Turk,D., Bogyo,M., Turk,V. and Turk,B. Autocatalytic processing of procathepsin B is triggered by proenzyme activity FEBS J (2009) 276, 660-668. PubMed Europe PubMed DOI
Queiroz,A.F., Silva,R.A., Moura,R.M., Dreyfuss,J.L., Paredes-Gamero,E.J., Souza,A.C., Tersariol,I.L., Santos,E.A., Nader,H.B., Justo,G.Z. and de Sales,M.P. Growth inhibitory activity of a novel lectin from Cliona varians against K562 human erythroleukemia cells Cancer Chemother Pharmacol (2009) 63, 1023-1033. PubMed Europe PubMed DOI
Reich,M., Wieczerzak,E., Jankowska,E., Palesch,D., Boehm,B.O. and Burster,T. Specific cathepsin B inhibitor is cell-permeable and activates presentation of TTC in primary human dendritic cells Immunol Lett (2009) 123, 155-159. PubMed Europe PubMed DOI I
Serbielle,C., Moreau,S., Veillard,F., Voldoire,E., Bezier,A., Mannucci,M.A., Volkoff,A.N., Drezen,J.M., Lalmanach,G. and Huguet,E. Identification of parasite-responsive cysteine proteases in Manduca sexta Biol Chem (2009) 390, 493-502. PubMed Europe PubMed DOI
Yan,B.Z., Wang,W., Chen,L.Y., Bi,M.R., Lu,Y.J., Li,B.X. and Yang,B.S. Role of cathepsin B-mediated apoptosis in fulminant hepatic failure in mice World J Gastroenterol (2009) 15, 1231-1236. PubMed Europe PubMed DOI PMC EPMC I
Zhang,H., Zhong,C., Shi,L., Guo,Y. and Fan,Z. Granulysin induces cathepsin B release from lysosomes of target tumor cells to attack mitochondria through processing of Bid leading to necroptosis J Immunol (2009) 182, 6993-7000. PubMed Europe PubMed DOI
Zhou,Z., Wang,Y. and Bryant,S.H. Computational analysis of the cathepsin B inhibitors activities through LR-MMPBSA binding affinity calculation based on docked complex J Comput Chem (2009) 30, 2165-2175. PubMed Europe PubMed DOI PMC EPMC I

2008

Casini,A., Gabbiani,C., Sorrentino,F., Rigobello,M.P., Bindoli,A., Geldbach,T.J., Marrone,A., Re,N., Hartinger,C.G., Dyson,P.J. and Messori,L. Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds J Med Chem (2008) 51, 6773-6781. PubMed Europe PubMed DOI I
Gunatilleke,S.S. and Barrios,A.M. Tuning the Au(I)-mediated inhibition of cathepsin B through ligand substitutions J Inorg Biochem (2008) 102, 555-563. PubMed Europe PubMed DOI I
Gunatilleke,S.S., de Oliveira,C.A., McCammon,J.A. and Barrios,A.M. Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study J Biol Inorg Chem (2008) 13, 555-561. PubMed Europe PubMed DOI I
Ha,S.D., Martins,A., Khazaie,K., Han,J., Chan,B.M. and Kim,S.O. Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages J Immunol (2008) 181, 690-697. PubMed Europe PubMed
He,M., Xiao,Z., Li,S. and Chen,A. Cathepsin B antisense oligodeoxynucleotide suppresses invasive potential of MG-63 cells Acad J Xi'An Jiaotong Univ (2008) 20, 100-103.
Hoang,V.L., Li,Y. and Kim,S.K. Cathepsin B inhibitory activities of phthalates isolated from a marine Pseudomonas strain Bioorg Med Chem Lett (2008) 18, 2083-2088. PubMed Europe PubMed DOI I
Li,Y., Qian,Z.J. and Kim,S.K. Cathepsin B inhibitory activities of three new phthalate derivatives isolated from seahorse, Hippocampus Kuda Bleeler Bioorg Med Chem Lett (2008) 18, 6130-6134. PubMed Europe PubMed DOI I
Liu,H., Yin,L., Zhang,N., Li,S. and Ma,C. Isolation of cathepsin B from the muscle of silver carp (Hypophthalmichthys molitrix) and comparison of cathepsins B and L actions on surimi gel softening Food Chem (2008) 110, 310-318. PubMed Europe PubMed DOI
Myers,J., Ittiprasert,W., Raghavan,N., Miller,A. and Knight,M. Differences in cysteine protease activity in Schistosoma mansoni-resistant and -susceptible Biomphalaria glabrata and characterization of the hepatopancreas cathepsin B full-length cDNA J Parasitol (2008) 94, 659-668. PubMed Europe PubMed DOI PMC EPMC
Redzynia,I., Ljunggren,A., Abrahamson,M., Mort,J.S., Krupa,J.C., Jaskolski,M. and Bujacz,G. Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B J Biol Chem (2008) 283, 22815-22825. PubMed Europe PubMed DOI
Rispe,C., Kutsukake,M., Doublet,V., Hudaverdian,S., Legeai,F., Simon,J.C., Tagu,D. and Fukatsu,T. Large gene family expansion and variable selective pressures for cathepsin B in aphids Mol Biol Evol (2008) 25, 5-17. PubMed Europe PubMed DOI
Sakamoto,M., Miyamoto,K., Wu,Z. and Nakanishi,H. Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat Neurosci Lett (2008) 442, 292-296. PubMed Europe PubMed DOI I
Schenker,P., Alfarano,P., Kolb,P., Caflisch,A. and Baici,A. A double-headed cathepsin B inhibitor devoid of warhead Protein Sci (2008) 17, 2145-2155. PubMed Europe PubMed DOI PMC EPMC I
Shao,H.L., Dong,D.J., Hu,J.D., Wang,J.X. and Zhao,X.F. Construction of the recombinant baculovirus AcMNPV with cathepsin B-like proteinase and its insecticidal activity against Helicoverpa armigera Pestic Biochem Physiol (2008) 91, 141-146. DOI
Sun,B., Zhou,Y., Halabisky,B., Lo,I., Cho,S.H., Mueller-Steiner,S., Devidze,N., Wang,X., Grubb,A. and Gan,L. Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease Neuron (2008) 60, 247-257. PubMed Europe PubMed DOI PMC EPMC
Tsuji,N., Miyoshi,T., Battsetseg,B., Matsuo,T., Xuan,X. and Fujisaki,K. A cysteine protease is critical for Babesia spp. transmission in Haemaphysalis ticks PLoS Pathog (2008) 4, e1000062-e1000062. PubMed Europe PubMed DOI PMC EPMC
Vaananen,A.J., Salmenpera,P., Hukkanen,M., Miranda,K.M., Harjula,A., Rauhala,P. and Kankuri,E. Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide Free Radic Biol Med (2008) 45, 749-755. PubMed Europe PubMed DOI I
Vasiljeva,O., Korovin,M., Gajda,M., Brodoefel,H., Bojic,L., Kruger,A., Schurigt,U., Sevenich,L., Turk,B., Peters,C. and Reinheckel,T. Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice Oncogene (2008) 27, 4191-4199. PubMed Europe PubMed DOI K
Wang,G.H., Chun,L., Xia,Q.Y., Zha,X.F., Jie,C. and Liang,J. Cathepsin B protease is required for metamorphism in silkworm, Bombyx mori Insect Sci (2008) 15, 201-208. DOI
Wang,X., Liu,B., Wang,G., Tang,B. and Xiang,J. Molecular cloning and functional analysis of cathepsin B in nutrient metabolism during larval development in Meretrix meretrix Aquaculture (2008) 282, 41-46. DOI
Yakovlev,A.A., Gorokhovatsky,A.Y., Onufriev,M.V., Beletsky,I.P. and Gulyaeva,N.V. Brain cathepsin B cleaves a caspase substrate Biochemistry (Mosc) (2008) 73, 332-336. PubMed Europe PubMed DOI
Zhang,F.T., Zhang,Y.B., Chen,Y.D., Zhu,R., Dong,C.W., Li,Y.Y., Zhang,Q.Y. and Gui,J.F. Expressional induction of Paralichthys olivaceus cathepsin B gene in response to virus, poly I:C and lipopolysaccharide Fish Shellfish Immunol (2008) 25, 542-549. PubMed Europe PubMed DOI

2007

Buth,H., Luigi Buttigieg,P., Ostafe,R., Rehders,M., Dannenmann,S.R., Schaschke,N., Stark,H.J., Boukamp,P. and Brix,K. Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes Eur J Cell Biol (2007) 86, 747-761. PubMed Europe PubMed DOI
Caglic,D., Pungercar,J.R., Pejler,G., Turk,V. and Turk,B. Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions J Biol Chem (2007) 282, 33076-33085. PubMed Europe PubMed DOI
Fujisawa,A., Kambe,N., Saito,M., Nishikomori,R., Tanizaki,H., Kanazawa,N., Adachi,S., Heike,T., Sagara,J., Suda,T., Nakahata,T. and Miyachi,Y. Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells Blood (2007) 109, 2903-2911. PubMed Europe PubMed DOI I
Konno,H., Kubo,K., Makabe,H., Toshiro,E., Hinoda,N., Nosaka,K. and Akaji,K. Total synthesis of miraziridine A and identification of its major reaction site for cathepsin B Tetrahedron (2007) 63, 9502-9513. DOI I
Link,M.A., Silva,L.A. and Schaffer,P.A. Cathepsin B mediates cleavage of herpes simplex virus type 1 origin binding protein (OBP) to yield OBPC-1, and cleavage is dependent upon viral DNA replication J Virol (2007) 81, 9175-9182. PubMed Europe PubMed DOI PMC EPMC
Myers,M.C., Napper,A.D., Motlekar,N., Shah,P.P., Chiu,C.H., Beavers,M.P., Diamond,S.L., Huryn,D.M. and Smith,A.B., III Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays Bioorg Med Chem Lett (2007) 17, 4761-4766. PubMed Europe PubMed DOI PMC EPMC
Ruettger,A. and Wiederanders,B. Microplate assay for cathepsin detection in viable cells using derivatives of 4-methoxy-beta-naphthylamide Curr Protoc Protein Sci (2007) Unit 21.21, Unit 21.21- PubMed Europe PubMed DOI A
Schmid,B., Chung,D.E., Warnecke,A., Fichtner,I. and Kratz,F. Albumin-binding prodrugs of camptothecin and doxorubicin with an Ala-Leu-Ala-Leu-linker that are cleaved by cathepsin B: synthesis and antitumor efficacy Bioconjug Chem (2007) 18, 702-716. PubMed Europe PubMed DOI
Sitabkhan,Y. and Frankfater,A. Differences in the expression of cathepsin B in B16 melanoma metastatic variants depend on transcription factor Sp1 DNA Cell Biol (2007) 26, 673-682. PubMed Europe PubMed DOI
Stahl,S., Reinders,Y., Asan,E., Mothes,W., Conzelmann,E., Sickmann,A. and Felbor,U. Proteomic analysis of cathepsin B- and L-deficient mouse brain lysosomes Biochim Biophys Acta (2007) 1774, 1237-1246. PubMed Europe PubMed DOI K
Weiss,F.U., Behn,C.O., Simon,P., Ruthenburger,M., Halangk,W. and Lerch,M.M. Cathepsin B gene polymorphism Val26 is not associated with idiopathic chronic pancreatitis in European patients Gut (2007) 56, 1322-1323. PubMed Europe PubMed DOI M
Wieczerzak,E., Rodziewicz-Motowidlo,S., Jankowska,E., Gieldon,A. and Ciarkowski,J. An enormously active and selective azapeptide inhibitor of cathepsin B J Pept Sci (2007) 13, 536-543. PubMed Europe PubMed DOI I
Yang,X.M., Hou,L.J., Wang,J.X. and Zhao,X.F. Expression and function of cathepsin B-like proteinase in larval hemocytes of Helicoverpa armigera during metamorphosis Arch Insect Biochem Physiol (2007) 64, 164-174. PubMed Europe PubMed DOI

2006

Baici,A., Muntener,K., Willimann,A. and Zwicky,R. Regulation of human cathepsin B by alternative mRNA splicing: homeostasis, fatal errors and cell death Biol Chem (2006) 387, 1017-1021. PubMed Europe PubMed DOI R
Baird,I.R., Mosi,R., Olsen,M., Cameron,B.R., Fricker,S.P. and Skerlj,R.T. '3 + 1' mixed-ligand oxorhenium(V) complexes and their inhibition of the cysteine proteases cathepsin B and cathepsin K Inorganica Chimica Acta (2006) 359, 2736-2750. I
[YEAR:16-8-2006]Baran,K., Ciccone,A., Peters,C., Yagita,H., Bird,P.I., Villadangos,J.A. and Trapani,J.A. Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells J Biol Chem (16-8-2006) 281, 30485-30491. PubMed Europe PubMed DOI
[YEAR:6-3-2006]Choe,Y., Leonetti,F., Greenbaum,D.C., Lecaille,F., Bogyo,M., Bromme,D., Ellman,J.A. and Craik,C.S. Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities J Biol Chem (6-3-2006) 281, 12824-12832. PubMed Europe PubMed DOI P
[YEAR:21-9-2006]Cole,G.M. and Frautschy,S.A. Cat and mouse Neuron (21-9-2006) 51, 671-672. PubMed Europe PubMed DOI
Frlan,R. and Gobec,S. Inhibitors of cathepsin B Curr Med Chem (2006) 13, 2309-2327. PubMed Europe PubMed DOI V
[YEAR:20-12-2006]Hang,H.C., Loureiro,J., Spooner,E., van der Velden,A.W., Kim,Y.M., Pollington,A.M., Maehr,R., Starnbach,M.N. and Ploegh,H.L. Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells ACS Chem Biol (20-12-2006) 1, 713-723. PubMed Europe PubMed DOI I
Jane,D.T., Morvay,L., Dasilva,L., Cavallo-Medved,D., Sloane,B.F. and Dufresne,M.J. Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH Biol Chem (2006) 387, 223-234. PubMed Europe PubMed DOI
Lerch,M.M. and Halangk,W. Human pancreatitis and the role of cathepsin B Gut (2006) 55, 1228-1230. PubMed Europe PubMed DOI PMC EPMC
[YEAR:9-3-2006]Lindkvist,B., Fajardo,I., Pejler,G. and Borgstrom,A. Cathepsin B activates human trypsinogen 1 but not proelastase 2 or procarboxypeptidase B Pancreatology (9-3-2006) 6, 224-231. PubMed Europe PubMed DOI
Linke,M., Gordon,R.E., Brillard,M., Lecaille,F., Lalmanach,G. and Bromme,D. Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins Biol Chem (2006) 387, 1295-1303. PubMed Europe PubMed DOI P
[YEAR:21-2-2006]Mahurkar,S., Idris,M.M., Reddy,D.N., Bhaskar,S., Rao,G.V., Thomas,V., Singh,L. and Chandak,G.R. Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis Gut (21-2-2006) 55, 1270-1275. PubMed Europe PubMed DOI PMC EPMC
[YEAR:24-8-2006]Mosi,R., Baird,I.R., Cox,J., Anastassov,V., Cameron,B., Skerlj,R.T. and Fricker,S.P. Rhenium inhibitors of cathepsin B (ReO(SYS)X (where Y = S, py; X = Cl, Br, SPhOMe-p)): synthesis and mechanism of inhibition J Med Chem (24-8-2006) 49, 5262-5272. PubMed Europe PubMed DOI I
[YEAR:21-9-2006]Mueller-Steiner,S., Zhou,Y., Arai,H., Roberson,E.D., Sun,B., Chen,J., Wang,X., Yu,G., Esposito,L., Mucke,L. and Gan,L. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease Neuron (21-9-2006) 51, 703-714. PubMed Europe PubMed DOI
[YEAR:28-11-2006]Premzl,A., Turk,V. and Kos,J. Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro J Cell Biochem (28-11-2006) 97, 1230-1240. PubMed Europe PubMed DOI I
Ruttger,A., Mollenhauer,J., Loser,R., Gutschow,M. and Wiederanders,B. Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-beta-naphthylamide Biotechniques (2006) 41, 469-473. PubMed Europe PubMed DOI A
[YEAR:17-2-2006]Ruzza,P., Quintieri,L., Osler,A., Calderan,A., Biondi,B., Floreani,M., Guiotto,A. and Borin,G. Fluorescent, internally quenched, peptides for exploring the pH-dependent substrate specificity of cathepsin B J Pept Sci (17-2-2006) 12, 455-461. PubMed Europe PubMed DOI P
[YEAR:12-10-2006]Taha,T.A., El-Alwani,M., Hannun,Y.A. and Obeid,L.M. Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease FEBS Lett (12-10-2006) 580, 6047-6054. PubMed Europe PubMed DOI PMC EPMC P
Tan,Y., Osatomi,K., Nozaki,Y., Ishihara,T. and Hara,K. Occurrence of two distinct molecular species of cathepsin B in carp Cyprinus carpio Fish Sci (2006) 72, 185-194.
Tan,Y., Osatomi,K. and Hara,K. Gene structure of carp Cyprinus carpio cathepsin B Fish Sci (2006) 72, 673-678. DOI
[YEAR:1-8-2006]Watanabe,D., Yamamoto,A., Tomoo,K., Matsumoto,K., Murata,M., Kitamura,K. and Ishida,T. Quantitative evaluation of each catalytic subsite of cathepsin B for inhibitory activity based on inhibitory activity-binding mode relationship of epoxysuccinyl inhibitors by X-ray crystal structure analyses of complexes J Mol Biol (1-8-2006) 362, 979-993. PubMed Europe PubMed DOI S I
Yang,X.M., Hou,L.J., Dong,D.J., Shao,H.L., Wang,J.X. and Zhao,X.F. Cathepsin B-like proteinase is involved in the decomposition of the adult fat body of Helicoverpa armigera Arch Insect Biochem Physiol (2006) 62, 1-10. PubMed Europe PubMed DOI
[YEAR:5-7-2006]Zeng,G.Z., Pan,X.L., Tan,N.H., Xiong,J. and Zhang,Y.M. Natural biflavones as novel inhibitors of cathepsin B and K Eur J Med Chem (5-7-2006) 41, 1247-1252. PubMed Europe PubMed DOI I

2005

[YEAR:7-10-2005]Baskin-Bey,E.S., Canbay,A., Bronk,S.F., Werneburg,N., Guicciardi,M.E., Nyberg,S.L. and Gores,G.J. Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury Am J Physiol Gastrointest Liver Physiol (7-10-2005) 288, G396-G402. PubMed Europe PubMed DOI
[YEAR:4-4-2005]Bestvater,F., Dallner,C. and Spiess,E. The C-terminal subunit of artificially truncated human cathepsin B mediates its nuclear targeting and contributes to cell viability BMC Cell Biol (4-4-2005) 6, 16-16. PubMed Europe PubMed DOI PMC EPMC
Ellis,R.C., O'Steen,W.A., Hayes,R.L., Nick,H.S., Wang,K.K. and Anderson,D.K. Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat Exp Neurol (2005) 193, 19-28. PubMed Europe PubMed DOI
Hook,V., Toneff,T., Bogyo,M., Greenbaum,D., Medzihradszky,K.F., Neveu,J., Lane,W., Hook,G. and Reisine,T. Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease Biol Chem (2005) 386, 931-940. PubMed Europe PubMed DOI I
[YEAR:18-5-2005]Im,E., Venkatakrishnan,A. and Kazlauskas,A. Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells Mol Biol Cell (18-5-2005) 16, 3488-3500. PubMed Europe PubMed DOI PMC EPMC
Koike,M., Shibata,M., Waguri,S., Yoshimura,K., Tanida,I., Kominami,E., Gotow,T., Peters,C., von Figura,K., Mizushima,N., Saftig,P. and Uchiyama,Y. Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease) Am J Pathol (2005) 167, 1713-1728. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:25-3-2005]Muntener,K., Willimann,A., Zwicky,R., Svoboda,B., Mach,L. and Baici,A. Folding competence of N-terminally truncated forms of human procathepsin B J Biol Chem (25-3-2005) 280, 11973-11980. PubMed Europe PubMed DOI
Rocken,C., Menard,R., Buhling,F., Vockler,S., Raynes,J., Stix,B., Kruger,S., Roessner,A. and Kahne,T. Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation Ann Rheum Dis (2005) 64, 808-815. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-4-2005]Wickramasinghe,N.S., Nagaraj,N.S., Vigneswaran,N. and Zacharias,W. Cathepsin B promotes both motility and invasiveness of oral carcinoma cells Arch Biochem Biophys (1-4-2005) 436, 187-195. PubMed Europe PubMed DOI
Wieczerzak,E., Jankowska,E., Rodziewicz-Motowidlo,S., Gieldon,A., Lagiewka,J., Grzonka,Z., Abrahamson,M., Grubb,A. and Bromme,D. Novel azapeptide inhibitors of cathepsins B and K. Structural background to increased specificity for cathepsin B J Pept Res (2005) 66 Suppl 1, 1-11. PubMed Europe PubMed DOI I
[YEAR:14-12-2005]Zhao,X.F., An,X.M., Wang,J.X., Dong,D.J., Du,X.J., Sueda,S. and Kondo,H. Expression of the Helicoverpa cathepsin B-like proteinase during embryonic development Arch Insect Biochem Physiol (14-12-2005) 58, 39-46. PubMed Europe PubMed DOI

2004

Benchoua,A., Braudeau,J., Reis,A., Couriaud,C. and Onteniente,B. Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemia J Cereb Blood Flow Metab (2004) 24, 1272-1279. PubMed Europe PubMed DOI
Bown,D.P., Wilkinson,H.S., Jongsma,M.A. and Gatehouse,J.A. Characterisation of cysteine proteinases responsible for digestive proteolysis in guts of larval western corn rootworm (Diabrotica virgifera) by expression in the yeast Pichia pastoris Insect Biochem Mol Biol (2004) 34, 305-320. PubMed Europe PubMed DOI P
[YEAR:1-1-2004]Broker,L.E., Huisman,C., Span,S.W., Rodriguez,J.A., Kruyt,F.A. and Giaccone,G. Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells Cancer Res (1-1-2004) 64, 27-30. PubMed Europe PubMed DOI
Buth,H., Wolters,B., Hartwig,B., Meier-Bornheim,R., Veith,H., Hansen,M., Sommerhoff,C.P., Schaschke,N., Machleidt,W., Fusenig,N.E., Boukamp,P. and Brix,K. HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration Eur J Cell Biol (2004) 83, 781-795. PubMed Europe PubMed DOI
[YEAR:15-12-2004]Cotrin,S.S., Puzer,L., de Souza Judice,W.A., Juliano,L., Carmona,A.K. and Juliano,M.A. Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B Anal Biochem (15-12-2004) 335, 244-252. PubMed Europe PubMed DOI A P
[YEAR:10-11-2004]Gan,L., Ye,S., Chu,A., Anton,K., Yi,S., Vincent,V.A., von Schack,D., Chin,D., Murray,J., Lohr,S., Patthy,L., Gonzalez-Zulueta,M., Nikolich,K. and Urfer,R. Identification of cathepsin B as a mediator of neuronal death induced by abeta-activated microglial cells using a functional genomics approach J Biol Chem (10-11-2004) 279, 5565-5572. PubMed Europe PubMed DOI
[YEAR:20-9-2004]Gondi,C.S., Lakka,S.S., Dinh,D.H., Olivero,W.C., Gujrati,M. and Rao,J.S. RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas Oncogene (20-9-2004) 23, 8486-8496. PubMed Europe PubMed DOI
[YEAR:25-8-2004]Lim,I.T., Meroueh,S.O., Lee,M., Heeg,M.J. and Mobashery,S. Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis J Am Chem Soc (25-8-2004) 126, 10271-10277. PubMed Europe PubMed DOI
Mort,J.S. Cathepsin B [ISSN:0-12-079610-4] (2004) 2, 1079-1086. V
[YEAR:15-7-2004]Muntener,K., Zwicky,R., Csucs,G., Rohrer,J. and Baici,A. Exon skipping of cathepsin B: mitochondrial targeting of a lysosomal peptidase provokes cell death J Biol Chem (15-7-2004) 279, 41012-41017. PubMed Europe PubMed DOI R
[YEAR:15-12-2004]Ravanko,K., Jarvinen,K., Helin,J., Kalkkinen,N. and Holtta,E. Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts Cancer Res (15-12-2004) 64, 8831-8838. PubMed Europe PubMed DOI
Stachowiak,K., Tokmina,M., Karpinska,A., Sosnowska,R. and Wiczk,W. Fluorogenic peptide substrates for carboxydipeptidase activity of cathepsin B Acta Biochim Pol (2004) 51, 81-92. PubMed Europe PubMed DOI
[YEAR:15-4-2004]Stern,I., Schaschke,N., Moroder,L. and Turk,D. Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft Biochem J (15-4-2004) 381, 511-517. PubMed Europe PubMed DOI PMC EPMC S I
[YEAR:4-8-2004]Yan,S. and Sloane,B.F. Isolation of a novel USF2 isoform: repressor of cathepsin B expression Gene (4-8-2004) 337, 199-206. PubMed Europe PubMed DOI
[YEAR:19-1-2004]Yanamandra,N., Gumidyala,K.V., Waldron,K.G., Gujrati,M., Olivero,W.C., Dinh,D.H., Rao,J.S. and Mohanam,S. Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis Oncogene (19-1-2004) 23, 2224-2230. PubMed Europe PubMed DOI

2003

Aoki,H., Ahsan,M.N. and Watabe,S. Molecular cloning and characterization of cathepsin B from the hepatopancreas of northern shrimp Pandalus borealis Comp Biochem Physiol B Biochem Mol Biol (2003) 134, 681-694. PubMed Europe PubMed DOI
Bervar,A., Zajc,I., Sever,N., Katunuma,N., Sloane,B.F. and Lah,T.T. Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors Biol Chem (2003) 384, 447-455. PubMed Europe PubMed DOI
Canbay,A., Guicciardi,M.E., Higuchi,H., Feldstein,A., Bronk,S.F., Rydzewski,R., Taniai,M. and Gores,G.J. Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis J Clin Invest (2003) 112, 152-159. PubMed Europe PubMed DOI PMC EPMC I
[YEAR:15-7-2003]Eijan,A.M., Sandes,E.O., Riveros,M.D., Thompson,S., Pasik,L., Mallagrino,H., Celeste,F. and Casabe,A.R. High expression of cathepsin B in transitional bladder carcinoma correlates with tumor invasion Cancer (15-7-2003) 98, 262-268. PubMed Europe PubMed DOI
Hentze,H., Lin,X.Y., Choi,M.S. and Porter,A.G. Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin Cell Death Differ (2003) 10, 956-968. PubMed Europe PubMed DOI
[YEAR:15-9-2003]Houseweart,M.K., Pennacchio,L.A., Vilaythong,A., Peters,C., Noebels,J.L. and Myers,R.M. Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1) J Neurobiol (15-9-2003) 56, 315-327. PubMed Europe PubMed DOI
Kamino,H., Hiratsuka,M., Toda,T., Nishigaki,R., Osaki,M., Ito,H., Inoue,T. and Oshimura,M. Searching for genes involved in arteriosclerosis: proteomic analysis of cultured human umbilical vein endothelial cells undergoing replicative senescence Cell Struct Funct (2003) 28, 495-503. PubMed Europe PubMed DOI
Kikuchi,H., Yamada,T., Furuya,H., Doh-Ura,K., Ohyagi,Y., Iwaki,T. and Kira,J. Involvement of cathepsin B in the motor neuron degeneration of amyotrophic lateral sclerosis Acta Neuropathol (Berl) (2003) 105, 462-468. PubMed Europe PubMed DOI
Muntener,K., Zwicky,R., Csucs,G. and Baici,A. The alternative use of exons 2 and 3 in cathepsin B mRNA controls enzyme trafficking and triggers nuclear fragmentation in human cells Histochem Cell Biol (2003) 119, 93-101. PubMed Europe PubMed DOI
Podgorski,I. and Sloane,B.F. Cathepsin B and its role(s) in cancer progression Biochem Soc Symp (2003) 2003, 263-276. PubMed Europe PubMed
[YEAR:15-2-2003]Premzl,A., Zavasnik-Bergant,V., Turk,V. and Kos,J. Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro Exp Cell Res (15-2-2003) 283, 206-214. PubMed Europe PubMed DOI
Sentandreu,M.A., Aubry,L. and Ouali,A. Purification of bovine cathepsin B: proteomic characterization of the different forms and production of specific antibodies Biochem Cell Biol (2003) 81, 317-326. PubMed Europe PubMed DOI
[YEAR:15-8-2003]Sweeney,D., Raymer,M.L. and Lockwood,T.D. Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents Biochem Pharmacol (15-8-2003) 66, 663-677. PubMed Europe PubMed DOI
Yan,S. and Sloane,B.F. Molecular regulation of human cathepsin B: implication in pathologies Biol Chem (2003) 384, 845-854. PubMed Europe PubMed DOI
Yan,S., Jane,D.T., Dufresne,M.J. and Sloane,B.F. Transcription of cathepsin B in glioma cells: regulation by an E-box adjacent to the transcription initiation site Biol Chem (2003) 384, 1421-1427. PubMed Europe PubMed DOI
Zwicky,R., Muntener,K., Csucs,G., Goldring,M.B. and Baici,A. Exploring the role of 5' alternative splicing and of the 3'-untranslated region of cathepsin B mRNA Biol Chem (2003) 384, 1007-1018. PubMed Europe PubMed DOI

2002

Baig,S., Damian,R.T. and Peterson,D.S. A novel cathepsin B active site motif is shared by helminth bloodfeeders Exp Parasitol (2002) 101, 83-89. PubMed Europe PubMed DOI
Cathers,B.E., Barrett,C., Palmer,J.T. and Rydzewski,R.M. pH Dependence of inhibitors targeting the occluding loop of cathepsin B Bioorg Chem (2002) 30, 264-275. PubMed Europe PubMed DOI I
[YEAR:15-11-2002]Cezari,M.H., Puzer,L., Juliano,M.A., Carmona,A.K. and Juliano,L. Cathepsin B carboxydipeptidase specificity analysis using internally quenched fluorescent peptides Biochem J (15-11-2002) 368, 365-369. PubMed Europe PubMed DOI PMC EPMC A
[YEAR:5-7-2002]Ebert,D.H., Deussing,J., Peters,C. and Dermody,T.S. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells J Biol Chem (5-7-2002) 277, 24609-24617. PubMed Europe PubMed DOI
[YEAR:11-6-2002]Felbor,U., Kessler,B., Mothes,W., Goebel,H.H., Ploegh,H.L., Bronson,R.T. and Olsen,B.R. Neuronal loss and brain atrophy in mice lacking cathepsins B and L Proc Natl Acad Sci U S A (11-6-2002) 99, 7883-7888. PubMed Europe PubMed DOI PMC EPMC K
Gray,A.W., Davies,M.E. and Jeffcott,L.B. Localisation and activity of cathepsins K and B in equine osteoclasts Res Vet Sci (2002) 72, 95-103. PubMed Europe PubMed DOI
[YEAR:26-4-2002]Guo,M., Mathieu,P.A., Linebaugh,B., Sloane,B.F. and Reiners,J.J., Jr. Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-beta - a process initiated by the exocytosis of cathepsin B J Biol Chem (26-4-2002) 277, 14829-14837. PubMed Europe PubMed DOI I
Jane,D.T., Dasilva,L., Koblinski,J., Horwitz,M., Sloane,B.F. and Dufresne,M.J. Evidence for the involvement of cathepsin B in skeletal myoblast differentiation J Cell Biochem (2002) 84, 520-531. PubMed Europe PubMed DOI
[YEAR:1-2-2002]Krupa,J.C., Hasnain,S., Nagler,D.K., Menard,R. and Mort,J.S. S2' substrate specificity and the role of His110 and His111 in the exopeptidase activity of human cathepsin B Biochem J (1-2-2002) 361, 613-619. PubMed Europe PubMed DOI PMC EPMC
Schaschke,N., Deluca,D., Assfalg-Machleidt,I., Hohneke,C., Sommerhoff,C.P. and Machleidt,W. Epoxysuccinyl peptide-derived cathepsin B inhibitors: modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin Biol Chem (2002) 383, 849-852. PubMed Europe PubMed DOI I
Teich,N., Bodeker,H. and Keim,V. Cathepsin B cleavage of the trypsinogen activation peptide BMC Gastroenterol (2002) 2, 16-16. PubMed Europe PubMed DOI PMC EPMC
Van Acker,G.J., Saluja,A.K., Bhagat,L., Singh,V.P., Song,A.M. and Steer,M.L. Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity Am J Physiol Gastrointest Liver Physiol (2002) 283, G794-G800. PubMed Europe PubMed DOI
[YEAR:12-9-2002]Wieczerzak,E., Drabik,P., Lankiewicz,L., Oldziej,S., Grzonka,Z., Abrahamson,M., Grubb,A. and Bromme,D. Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases J Med Chem (12-9-2002) 45, 4202-4211. PubMed Europe PubMed DOI I
[YEAR:3-6-2002]Yamamoto,A., Tomoo,K., Matsugi,K., Hara,T., In,Y., Murata,M., Kitamura,K. and Ishida,T. Structural basis for development of cathepsin B-specific noncovalent-type inhibitor: crystal structure of cathepsin B-E64c complex Biochim Biophys Acta (3-6-2002) 1597, 244-251. PubMed Europe PubMed DOI S I
[YEAR:1-10-2002]Zwicky,R., Muntener,K., Goldring,M.B. and Baici,A. Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes Biochem J (1-10-2002) 367, 209-217. PubMed Europe PubMed DOI PMC EPMC

2001

[YEAR:28-5-2001]Foghsgaard,L., Wissing,D., Mauch,D., Lademann,U., Bastholm,L., Boes,M., Elling,F., Leist,M. and Jaattela,M. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor J Cell Biol (28-5-2001) 153, 999-1010. PubMed Europe PubMed DOI PMC EPMC
[YEAR:31-8-2001]Gray,J., Haran,M.M., Schneider,K., Vesce,S., Ray,A.M., Owen,D., White,I.R., Cutler,P. and Davis,J.B. Evidence that inhibition of cathepsin-B contributes to the neuroprotective properties of caspase inhibitor Tyr-Val-Ala-Asp-chloromethyl ketone J Biol Chem (31-8-2001) 276, 32750-32755. PubMed Europe PubMed DOI I
[YEAR:20-12-2001]Greenspan,P.D., Clark,K.L., Tommasi,R.A., Cowen,S.D., McQuire,L.W., Farley,D.L., Van Duzer,J.H., Goldberg,R.L., Zhou,H.H., Du,Z.M., Fitt,J.J., Coppa,D.E., Fang,Z., Macchia,W., Zhu,L.J., Capparelli,M.P., Goldstein,R., Wigg,A.M., Doughty,J.R., Bohacek,R.S. and Knap,A.K. Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design J Med Chem (20-12-2001) 44, 4524-4534. PubMed Europe PubMed DOI I
Guicciardi,M.E., Miyoshi,H., Bronk,S.F. and Gores,G.J. Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications Am J Pathol (2001) 159, 2045-2054. PubMed Europe PubMed PMC EPMC
Kingham,P.J. and Pocock,J.M. Microglial secreted cathepsin B induces neuronal apoptosis J Neurochem (2001) 76, 1475-1484. PubMed Europe PubMed DOI I
[YEAR:1-6-2001]Melo,R.L., Alves,L.C., Del Nery,E., Juliano,L. and Juliano,M.A. Synthesis and hydrolysis by cysteine and serine proteases of short internally quenched fluorogenic peptides Anal Biochem (1-6-2001) 293, 71-77. PubMed Europe PubMed DOI
[YEAR:5-5-2001]Melo,R.L., Barbosa Pozzo,R.C., Alves,L.C., Perissutti,E., Caliendo,G., Santagada,V., Juliano,L. and Juliano,M.A. Synthesis and hydrolysis by cathepsin B of fluorogenic substrates with the general structure benzoyl-X-ARG-MCA containing non-natural basic amino acids at position X Biochim Biophys Acta (5-5-2001) 1547, 82-94. PubMed Europe PubMed DOI
Menard,R., Therrien,C., Lachance,P., Sulea,T., Qo,H., Alvarez-Hernandez,A.D. and Roush,W.R. Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design Biol Chem (2001) 382, 839-845. PubMed Europe PubMed DOI I
[YEAR:16-3-2001]Quraishi,O. and Storer,A.C. Identification of internal autoproteolytic cleavage sites within the prosegments of recombinant procathepsin B and procathepsin S. Contribution of a plausible unimolecular autoproteolytic event for the processing of zymogens belonging to the papain family J Biol Chem (16-3-2001) 276, 8118-8124. PubMed Europe PubMed DOI
Reinheckel,T., Deussing,J., Roth,W. and Peters,C. Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L Biol Chem (2001) 382, 735-741. PubMed Europe PubMed DOI K
[YEAR:6-7-2001]Szilagyi,L., Kenesi,E., Katona,G., Kaslik,G., Juhasz,G. and Graf,L. Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis J Biol Chem (6-7-2001) 276, 24574-24580. PubMed Europe PubMed DOI
[YEAR:15-4-2001]Szpaderska,A.M. and Frankfater,A. An intracellular form of cathepsin B contributes to invasiveness in cancer Cancer Res (15-4-2001) 61, 3493-3500. PubMed Europe PubMed
[YEAR:6-3-2001]Therrien,C., Lachance,P., Sulea,T., Purisima,E.O., Qi,H., Ziomek,E., Alvarez-Hernandez,A., Roush,W.R. and Menard,R. Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities Biochemistry (6-3-2001) 40, 2702-2711. PubMed Europe PubMed DOI I
Xu,Y. and Kawasaki,H. Isolation and expression of cathepsin B cDNA in hemocytes during metamorphosis of Bombyx mori Comp Biochem Physiol B Biochem Mol Biol (2001) 130, 393-399. PubMed Europe PubMed DOI

2000

Del Nery,E., Alves,L.C., Melo,R.L., Cesari,M.H., Juliano,L. and Juliano,M.A. Specificity of cathepsin B to fluorescent substrates containing benzyl side-chain-substituted amino acids at P1 subsite J Protein Chem (2000) 19, 33-38. PubMed Europe PubMed DOI P
Guicciardi,M.E., Deussing,J., Miyoshi,H., Bronk,S.F., Svingen,P.A., Peters,C., Kaufmann,S.H. and Gores,G.J. Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c J Clin Invest (2000) 106, 1127-1137. PubMed Europe PubMed DOI PMC EPMC
Halangk,W., Lerch,M.M., Brandt-Nedelev,B., Roth,W., Ruthenbuerger,M., Reinheckel,T., Domschke,W., Lippert,H., Peters,C. and Deussing,J. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis J Clin Invest (2000) 106, 773-781. PubMed Europe PubMed DOI PMC EPMC K
Hulkower,K.I., Butler,C.C., Linebaugh,B.E., Klaus,J.L., Keppler,D., Giranda,V.L. and Sloane,B.F. Fluorescent microplate assay for cancer cell-associated cathepsin B Eur J Biochem (2000) 267, 4165-4170. PubMed Europe PubMed DOI A
Jacobsen,W., Christians,U. and Benet,L.Z. In vitro evaluation of the disposition of a novel cysteine protease inhibitor Drug Metab Dispos (2000) 28, 1343-1351. PubMed Europe PubMed I
[YEAR:15-7-2000]Krupa,J.C. and Mort,J.S. Optimization of detergents for the assay of cathepsins B, L, S, and K Anal Biochem (15-7-2000) 283, 99-103. PubMed Europe PubMed DOI A
[YEAR:28-4-2000]Mai,J., Finley,R.L., Jr., Waisman,D.M. and Sloane,B.F. Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells J Biol Chem (28-4-2000) 275, 12806-12812. PubMed Europe PubMed DOI
Otsuka,T., Muramatsu,Y., Nakanishi,T., Hatanaka,H., Okamoto,M., Hino,M. and Hashimoto,S. WF14865A and B, new cathepsins B and L inhibitors produced by Aphanoascus fulvescens. I. Taxonomy, production, purification and biological properties J Antibiot (Tokyo) (2000) 53, 449-458. PubMed Europe PubMed I
[YEAR:29-12-2000]Pavlova,A., Krupa,J.C., Mort,J.S., Abrahamson,M. and Bjork,I. Cystatin inhibition of cathepsin B requires dislocation of the proteinase occluding loop. Demonstration by release of loop anchoring through mutation of His110 FEBS Lett (29-12-2000) 487, 156-160. PubMed Europe PubMed DOI
[YEAR:1-4-2000]Portaro,F.C., Santos,A.B., Cezari,M.H., Juliano,M.A., Juliano,L. and Carmona,E. Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2' and P3' variations in extended substrates Biochem J (1-4-2000) 347, 123-129. PubMed Europe PubMed DOI PMC EPMC
Schirmeister,T. and Peric,M. Aziridinyl peptides as inhibitors of cysteine proteases: effect of a free carboxylic acid function on inhibition Bioorg Med Chem (2000) 8, 1281-1291. PubMed Europe PubMed DOI I
[YEAR:23-6-2000]Song,J., Xu,P., Xiang,H., Su,Z., Storer,A.C. and Ni,F. The active-site residue Cys-29 is responsible for the neutral-pH inactivation and the refolding barrier of human cathepsin B FEBS Lett (23-6-2000) 475, 157-162. PubMed Europe PubMed DOI
Yamamoto,A., Tomoo,K., Miyagawa,H., Takaoka,Y., Sumiya,S., Kitamura,K. and Ishida,T. Molecular dynamics simulations of bovine cathepsin B and its complex with CA074 Chem Pharm Bull (Tokyo) (2000) 48, 480-485. PubMed Europe PubMed I

1999

Ando,R., Sakaki,T., Morinaka,Y., Takahashi,C., Tamao,Y., Yoshii,N., Katayama,S., Saito,K.I., Tokuyama,H., Isaka,M. and Nakamura,E. Cyclopropenone-containing cysteine proteinase inhibitors. Synthesis and enzyme inhibitory activities Bioorg Med Chem (1999) 7, 571-579. PubMed Europe PubMed I
[YEAR:22-1-1999]Jutras,I. and Reudelhuber,T.L. Prorenin processing by cathepsin B in vitro and in transfected cells FEBS Lett (22-1-1999) 443, 48-52. PubMed Europe PubMed DOI
[YEAR:1-12-1999]Krueger,S., Haeckel,C., Buehling,F. and Roessner,A. Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line Cancer Res (1-12-1999) 59, 6010-6014. PubMed Europe PubMed K
[YEAR:13-4-1999]Nagler,D.K., Tam,W., Storer,A.C., Krupa,J.C., Mort,J.S. and Menard,R. Interdependency of sequence and positional specificities for cysteine proteases of the papain family Biochemistry (13-4-1999) 38, 4868-4874. PubMed Europe PubMed DOI
Otani,T. and Matsukura,A. Cathepsin B inhibitors do not prevent the intracellular trypsinogen activation by secretagogue hyperstimulation Pancreas (1999) 19, 210-211. PubMed Europe PubMed I

1998

[YEAR:14-4-1998]Deussing,J., Roth,W., Saftig,P., Peters,C., Ploegh,H.L. and Villadangos,J.A. Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation Proc Natl Acad Sci U S A (14-4-1998) 95, 4516-4521. PubMed Europe PubMed DOI PMC EPMC K
Jones,B., Roberts,P.J., Faubion,W.A., Kominami,E. and Gores,G.J. Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line Am J Physiol (1998) 275, G723-G730. PubMed Europe PubMed
[YEAR:23-1-1998]Nycander,M., Estrada,S., Mort,J.S., Abrahamson,M. and Bjork,I. Two-step mechanism of inhibition of cathepsin B by cystatin C due to displacement of the proteinase occluding loop FEBS Lett (23-1-1998) 422, 61-64. PubMed Europe PubMed DOI
Peterson,J.J. and Meares,C.F. Cathepsin substrates as cleavable peptide linkers in bioconjugates, selected from a fluorescence quench combinatorial library Bioconjug Chem (1998) 9, 618-626. PubMed Europe PubMed DOI
Steed,P.M., Lasala,D., Liebman,J., Wigg,A., Clark,K. and Knap,A.K. Characterization of recombinant human cathepsin B expressed at high levels in baculovirus Protein Sci (1998) 7, 2033-2037. PubMed Europe PubMed DOI PMC EPMC E
[YEAR:5-6-1998]Yu,Y., Vranken,W., Goudreau,N., de Miguel,E., Magny,M.C., Mort,J.S., Dupras,R., Storer,A.C. and Ni,F. An NMR-based identification of peptide fragments mimicking the interactions of the cathepsin B propeptide FEBS Lett (5-6-1998) 429, 9-16. PubMed Europe PubMed DOI

1997

Gerhartz,B., Engh,R.A., Mentele,R., Eckerskorn,C., Torquato,R., Wittmann,J., Kolb,H.J., Machleidt,W., Fritz,H. and Auerswald,E.A. Quail cystatin: isolation and characterisation of a new member of the cystatin family and its hypothetical interaction with cathepsin B FEBS Lett (1997) 412, 551-558. PubMed Europe PubMed DOI
[YEAR:10-1-1997]Illy,C., Quraishi,O., Wang,J., Purisima,E., Vernet,T. and Mort,J.S. Role of the occluding loop in cathepsin B activity J Biol Chem (10-1-1997) 272, 1197-1202. PubMed Europe PubMed DOI
Mackay,E.A., Ehrhard,A., Moniatte,M., Guenet,C., Tardif,C., Tarnus,C., Sorokine,O., Heintzelmann,B., Nay,C., Remy,J.M., Higaki,J., Van Dorsselaer,A., Wagner,J., Danzin,C. and Mamont,P. A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease Eur J Biochem (1997) 244, 414-425. PubMed Europe PubMed
[YEAR:14-10-1997]Nagler,D.K., Storer,A.C., Portaro,F.C., Carmona,E., Juliano,L. and Menard,R. Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts Biochemistry (14-10-1997) 36, 12608-12615. PubMed Europe PubMed DOI
Podobnik,M., Kuhelj,R., Turk,V. and Turk,D. Crystal structure of the wild-type human procathepsin B at 2.5 A resolution reveals the native active site of a papain-like cysteine protease zymogen J Mol Biol (1997) 271, 774-788. PubMed Europe PubMed DOI S
Spizz,G. and Blackshear,P.J. Identification and characterization of cathepsin B as the cellular MARCKS cleaving enzyme J Biol Chem (1997) 272, 23833-23842. PubMed Europe PubMed DOI
Yamamoto,A., Hara,T., Tomoo,K., Ishida,T., Fujii,T., Hata,Y., Murata,M. and Kitamura,K. Binding mode of CA074, a specific irreversible inhibitor, to bovine cathepsin B as determined by X-ray crystal analysis of the complex J Biochem (1997) 121, 974-977. PubMed Europe PubMed S I
Yee,S.T., Okada,Y., Ogasawara,K., Omura,S., Takatsuki,A., Kakiuchi,T., Muno,D., Kominami,E. and Mizuochi,T. MHC class I presentation of an exogenous polypeptide antigen encoded by the murine AIDS defective virus Microbiol Immunol (1997) 41, 563-570. PubMed Europe PubMed I

1996

Bano,B., Kunapuli,S.P., Bradford,H.N. and Colman,R.W. Structural requirements for cathepsin B and cathepsin H inhibition by kininogens J Protein Chem (1996) 15, 519-525. PubMed Europe PubMed
Chagas,J.R., Ferrer-Di Martino,M., Gauthier,F. and Lalmanach,G. Inhibition of cathepsin B by its propeptide: use of overlapping peptides to identify a critical segment FEBS Lett (1996) 392, 233-236. PubMed Europe PubMed DOI
Chen,Y., Plouffe,C., Menard,R. and Storer,A.C. Delineating functionally important regions and residues in the cathepsin B propeptide for inhibitory activity FEBS Lett (1996) 393, 24-26. PubMed Europe PubMed DOI
Cygler,M., Sivaraman,J., Grochulski,P., Coulombe,R., Storer,A.C. and Mort,J.S. Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion Structure (1996) 4, 405-416. PubMed Europe PubMed S
Dehrmann,F.M., Elliott,E. and Dennison,C. Reductive activation markedly increases the stability of cathepsins B and L to extracellular ionic conditions Biol Chem Hoppe Seyler (1996) 377, 391-394. PubMed Europe PubMed
Dunn,A.D., Myers,H.E. and Dunn,J.T. The combined action of two thyroidal proteases releases T4 from the dominant hormone-forming site of thyroglobulin Endocrinology (1996) 137, 3279-3285. PubMed Europe PubMed DOI
Feng,M.H., Chan,S.L., Xiang,Y., Huber,C.P. and Lim,C. The binding mode of an E-64 analog to the active site of cathepsin B Protein Eng (1996) 9, 977-986. PubMed Europe PubMed I
Li,Z., Ortega-Vilain,A.C., Patil,G.S., Chu,D.L., Foreman,J.E., Eveleth,D.D. and Powers,J.C. Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases J Med Chem (1996) 39, 4089-4098. PubMed Europe PubMed DOI I
Salahuddin,A., Siddiqui,F.A. and Salahuddin,P. Isolation, purification and properties of cathepsin B from buffalo liver Indian J Biochem Biophys (1996) 33, 292-297. PubMed Europe PubMed
Salahuddin,A. and Kaur,H. Studies on activation and inhibition of cathepsin B from buffalo liver J Protein Chem (1996) 15, 87-93. PubMed Europe PubMed DOI
Sivaraman,J., Coloumbe,R., Magny,M.C., Mason,P., Mort,J.S. and Cygler,M. Crystallization of rat procathepsin B Acta Crystallogr D Biol Crystallogr (1996) 52, 874-875. PubMed Europe PubMed DOI
Turk,D., Podobnik,M., Kuhelj,R., Dolinar,M. and Turk,V. Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide FEBS Lett (1996) 384, 211-214. PubMed Europe PubMed DOI S

1995

Fox,T., Mason,P., Storer,A.C. and Mort,J.S. Modification of S1 subsite specificity in the cysteine protease cathepsin B Protein Eng (1995) 8, 53-57. PubMed Europe PubMed
[YEAR:15-4-1995]Kuhelj,R., Dolinar,M., Pungercar,J. and Turk,V. The preparation of catalytically active human cathepsin B from its precursor expressed in Escherichia coli in the form of inclusion bodies Eur J Biochem (15-4-1995) 229, 533-539. PubMed Europe PubMed
[YEAR:4-8-1995]Martichonok,V., Plouffe,C., Storer,A.C., Menard,R. and Jones,J.B. Aziridine analogs of [[trans-(epoxysuccinyl)-L-leucyl]amino]-4-guanidinobutane (E-64) as inhibitors of cysteine proteases J Med Chem (4-8-1995) 38, 3078-3085. PubMed Europe PubMed I
Taralp,A., Kaplan,H., Sytwu,I.I., Vlattas,I., Bohacek,R., Knap,A.K., Hirama,T., Huber,C.P. and Hasnain,S. Characterization of the S3 subsite specificity of cathepsin B J Biol Chem (1995) 270, 18036-18043. PubMed Europe PubMed DOI
Turk,D., Podobnik,M., Popovic,T., Katunuma,N., Bode,W., Huber,R. and Turk,V. Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: a basis for the design of specific epoxysuccinyl inhibitors Biochemistry (1995) 34, 4791-4797. PubMed Europe PubMed S I
Werle,B., Ebert,W., Klein,W. and Spiess,E. Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue Biol Chem Hoppe Seyler (1995) 376, 157-164. PubMed Europe PubMed I
[YEAR:15-11-1995]Yano,T., Takahashi,N., Kurata,S. and Natori,S. Regulation of the expression of cathepsin B in Sarcophaga peregrina (flesh fly) at the translational level during metamorphosis Eur J Biochem (15-11-1995) 234, 39-43. PubMed Europe PubMed

1994

Bromme,D., Bonneau,P.R., Lachance,P. and Storer,A.C. Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificity J Biol Chem (1994) 269, 30238-30242. PubMed Europe PubMed
Kirschke,H. and Wiederanders,B. Cathepsin S and related lysosomal endopeptidases Methods Enzymol (1994) 244, 500-511. PubMed Europe PubMed DOI V
Lindahl,P., Ripoll,D., Abrahamson,M., Mort,J.S. and Storer,A.C. Evidence for the interaction of valine-10 in cystatin C with the S2 subsite of cathepsin B Biochemistry (1994) 33, 4384-4392. PubMed Europe PubMed
Mach,L., Mort,J.S. and Glossl,J. Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme J Biol Chem (1994) 269, 13036-13040. PubMed Europe PubMed
Shinagawa,T., Nakayama,K., Uchiyama,Y., Kominami,E., Doi,Y., Hashiba,K., Yano,K., Hseu,W.A. and Murakami,K. Role of cathepsin B as prorenin processing enzyme in human kidney Hypertens Res (1994) 18, 131-136.
[YEAR:25-2-1994]Tam,S.W., Cote-Paulino,L.R., Peak,D.A., Sheahan,K. and Murnane,M.J. Human cathepsin B-encoding cDNAs: sequence variations in the 3'-untranslated region Gene (25-2-1994) 139, 171-176. PubMed Europe PubMed DOI
[YEAR:10-6-1994]Wagner,B.M., Smith,R.A., Coles,P.J., Copp,L.J., Ernest,M.J. and Krantz,A. In vivo inhibition of cathepsin B by peptidyl (acyloxy)methyl ketones J Med Chem (10-6-1994) 37, 1833-1840. PubMed Europe PubMed DOI I

1993

Bihovsky,R., Powers,J.C., Kam,C.M., Walton,R. and Loewi,R.C. Further evidence for the importance of free carboxylate in epoxysuccinate inhibitors of thiol proteases J Enzyme Inhib (1993) 7, 15-25. PubMed Europe PubMed I
Giordano,C., Calabretta,R., Gallina,C., Consalvi,V., Scandurra,R., Chiaia Noya,F. and Franchini,C. Iodo and diiodotyrosine epoxysuccinyl derivatives as selective inhibitors of cathepsin B Eur J Med Chem (1993) 28, 917-926. I
[YEAR:5-1-1993]Hasnain,S., Hirama,T., Huber,C.P., Mason,P. and Mort,J.S. Characterization of cathepsin B specificity by site-directed mutagenesis. Importance of Glu245 in the S2-P2 specificity for arginine and its role in transition state stabilization J Biol Chem (5-1-1993) 268, 235-240. PubMed Europe PubMed
Menard,R., Carmona,E., Plouffe,C., Bromme,D., Konishi,Y., Lefebvre,J. and Storer,A.C. The specificity of the S1' subsite of cysteine proteases FEBS Lett (1993) 328, 107-110. PubMed Europe PubMed DOI
Mordier,S., Bechet,D., Roux,M.P., Obled,A. and Ferrara,M. Nucleotide sequence of bovine preprocathepsin B. A study of polymorphism in the protein coding region Biochim Biophys Acta (1993) 1174, 305-311. PubMed Europe PubMed DOI M
[YEAR:15-11-1993]Takahashi,N., Kurata,S. and Natori,S. Molecular cloning of cDNA for the 29 kDa proteinase participating in decomposition of the larval fat body during metamorphosis of Sarcophaga peregrina (flesh fly) FEBS Lett (15-11-1993) 334, 153-157. PubMed Europe PubMed DOI

1992

Ahmed,N.K., Martin,L.A., Watts,L.M., Palmer,J., Thornburg,L., Prior,J. and Esser,R.E. Peptidyl fluoromethyl ketones as inhibitors of cathepsin B. Implication for treatment of rheumatoid arthritis Biochem Pharmacol (1992) 44, 1201-1207. PubMed Europe PubMed DOI I
Buttle,D.J., Murata,M., Knight,C.G. and Barrett,A.J. CA074 methyl ester: a proinhibitor for intracellular cathepsin B Arch Biochem Biophys (1992) 299, 377-380. PubMed Europe PubMed DOI I
Cejudo,F.J., Murphy,G., Chinoy,C. and Baulcombe,D.C. A gibberellin-regulated gene from wheat with sequence homology to cathepsin B of mammalian cells Plant J (1992) 2, 937-948. PubMed Europe PubMed
[YEAR:22-12-1992]Fox,T., de Miguel,E., Mort,J.S. and Storer,A.C. Potent slow-binding inhibition of cathepsin B by its propeptide Biochemistry (22-12-1992) 31, 12571-12576. PubMed Europe PubMed DOI
Kurata,S., Saito,H. and Natori,S. The 29-kDa hemocyte proteinase dissociates fat body at metamorphosis of Sarcophaga Dev Biol (1992) 153, 115-121. PubMed Europe PubMed DOI
[YEAR:1-3-1992]Kurata,S., Saito,H. and Natori,S. Purification of a 29-kDa hemocyte proteinase of Sarcophaga peregrina Eur J Biochem (1-3-1992) 204, 911-914. PubMed Europe PubMed
[YEAR:1-10-1992]Ohshita,T., Nikawa,T., Towatari,T. and Katunuma,N. Effects of selective inhibition of cathepsin B and general inhibition of cysteine proteinases on lysosomal proteolysis in rat liver in vivo and in vitro Eur J Biochem (1-10-1992) 209, 223-231. PubMed Europe PubMed DOI I
Yamamoto,A., Kaji,T., Tomoo,K., Ishida,T., Inoue,M., Murata,M. and Kitamura,K. Crystallization and preliminary X-ray study of the cathepsin B complexed with CA074, a selective inhibitor J Mol Biol (1992) 227, 942-944. PubMed Europe PubMed DOI S I

1991

Kobayashi,H., Schmitt,M., Goretzki,L., Chucholowski,N., Calvete,J., Kramer,M., Gunzler,W.A., Janicke,F. and Graeff,H. Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (pro-uPA) J Biol Chem (1991) 266, 5147-5152. PubMed Europe PubMed
Krantz,A., Copp,L.J., Coles,P.J., Smith,R.A. and Heard,S.B. Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases Biochemistry (1991) 30, 4678-4687. PubMed Europe PubMed I
Murata,M., Miyashita,S., Yokoo,C., Tamai,M., Hanada,K., Hatayama,K., Towatari,T., Nikawa,T. and Katunuma,N. Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro FEBS Lett (1991) 280, 307-310. PubMed Europe PubMed DOI I
Musil,D., Zucic,D., Turk,D., Engh,R.A., Mayr,I., Huber,R., Popovic,T., Turk,V., Towatari,T., Katunuma,N. and Bode,W. The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity EMBO J (1991) 10, 2321-2330. PubMed Europe PubMed PMC EPMC S
Reyes,V.E., Lu,S. and Humphreys,R.E. Cathepsin B cleavage of Ii from class II MHC alpha- and beta-chains J Immunol (1991) 146, 3877-3880. PubMed Europe PubMed
Tchoupe,J.R., Moreau,T., Gauthier,F. and Bieth,J.G. Photometric or fluorometric assay of cathepsin B, L and H and papain using substrates with an aminotrifluoromethylcoumarin leaving group Biochim Biophys Acta (1991) 1076, 149-151. PubMed Europe PubMed DOI A
Towatari,T., Nikawa,T., Murata,M., Yokoo,C., Tamai,M., Hanada,K. and Katunuma,N. Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo FEBS Lett (1991) 280, 311-315. PubMed Europe PubMed DOI I

1990

Ferrara,M., Wojcik,F., Rhaissi,H., Mordier,S., Roux,M.P. and Bechet,D. Gene structure of mouse cathepsin B FEBS Lett (1990) 273, 195-199. PubMed Europe PubMed DOI
Hu,L.Y. and Abeles,R.H. Inhibition of cathepsin B and papain by peptidyl alpha-keto esters, alpha-keto amides, alpha-diketones, and alpha-keto acids Arch Biochem Biophys (1990) 281, 271-274. PubMed Europe PubMed DOI I
Kurata,S., Saito,H. and Natori,S. Participation of hemocyte proteinase in dissociation of the fat body on pupation of Sarcophaga peregrina (flesh fly) Insect Biochemistry (1990) 20, 461-465.
Nguyen,Q., Mort,J.S. and Roughley,P.J. Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B Biochem J (1990) 266, 569-573. PubMed Europe PubMed PMC EPMC
Sloane,B.F., Moin,K., Krepela,E. and Rozhin,J. Cathepsin B and its endogenous inhibitors: the role in tumor malignancy Cancer Metastasis Rev (1990) 9, 333-352. PubMed Europe PubMed DOI V

1989

Mason,R.W. Interaction of lysosomal cysteine proteinases with alpha2-macroglobulin: conclusive evidence for the endopeptidase activities of cathepsins B and H Arch Biochem Biophys (1989) 273, 367-374. PubMed Europe PubMed
[YEAR:25-1-1989]Schultz,R.M., Varma-Nelson,P., Ortiz,R., Kozlowski,K.A., Orawski,A.T., Pagast,P. and Frankfater,A. Active and inactive forms of the transition-state analog protease inhibitor leupeptin: explanation of the observed slow binding of leupeptin to cathepsin B and papain J Biol Chem (25-1-1989) 264, 1497-1507. PubMed Europe PubMed I

1988

[YEAR:1-1-1988]Baici,A., Lang,A., Horler,D. and Knopfel,M. Cathepsin B as a marker of the dedifferentiated chondrocyte phenotype Ann Rheum Dis (1-1-1988) 47, 684-691. PubMed Europe PubMed DOI
Crawford,C., Mason,R.W., Wikstrom,P. and Shaw,E. The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B Biochem J (1988) 253, 751-758. PubMed Europe PubMed PMC EPMC I
Figarella,C., Miszczuk-Jamska,B. and Barrett,A.J. Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid activation of human trypsinogen I Biol Chem Hoppe Seyler (1988) 369 Suppl, 293-298. PubMed Europe PubMed
Kirschke,H., Wikstrom,P. and Shaw,E. Active center differences between cathepsins L and B: the S1 binding region FEBS Lett (1988) 228, 128-130. PubMed Europe PubMed
Medina,M., Leon,P. and Vallejo,C.G. Drosophila cathepsin B-like proteinase: a suggested role in yolk degradation Arch Biochem Biophys (1988) 263, 355-363. PubMed Europe PubMed
Mort,J.S., Tam,A., Steiner,D.F. and Chan,S.J. Expression of rat and mouse cathepsin B precursors in Escherichia coli Biol Chem Hoppe Seyler (1988) 369 Suppl, 163-167. PubMed Europe PubMed

1987

[YEAR:1-2-1987]Angliker,H., Wikstrom,P., Rauber,P. and Shaw,E. The synthesis of lysylfluoromethanes and their properties as inhibitors of trypsin, plasmin and cathepsin B Biochem J (1-2-1987) 241, 871-875. PubMed Europe PubMed PMC EPMC I
Bromme,D., Bescherer,K., Kirschke,H. and Fittkau,S. Enzyme-substrate interactions in the hydrolysis of peptides by cathepsins B and H from rat liver Biochem J (1987) 245, 381-385. PubMed Europe PubMed PMC EPMC
Polgar,L. and Csoma,C. Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B J Biol Chem (1987) 262, 14448-14453. PubMed Europe PubMed I
Wang,X., Chan,S.J., Eddy,R.L., Byers,M.G., Fukushima,Y., Henry,W.M., Haley,L.L., Steiner,D.F. and Shows,T.B. Chromosome assignment of cathepsin B (CTSB) to 8p22 and cathepsin H (CTSH) to 15q24-q25 Cytogenet Cell Genet (1987) 46, 710-711.

1986

Chan,S.J., San Segundo,B., McCormick,M.B. and Steiner,D.F. Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs Proc Natl Acad Sci U S A (1986) 83, 7721-7725. PubMed Europe PubMed PMC EPMC
[YEAR:1-5-1986]Rich,D.H., Brown,M.A. and Barrett,A.J. Purification of cathepsin B by a new form of affinity chromatography Biochem J (1-5-1986) 235, 731-734. PubMed Europe PubMed PMC EPMC I
Takahashi,T., Dehdarani,A.H., Yonezawa,S. and Tang,J. Porcine spleen cathepsin B is an exopeptidase J Biol Chem (1986) 261, 9375-9381. PubMed Europe PubMed

1985

Figarella,C., Amouric,M., Guy-Crotte,O. and Barrett,A.J. Activation of human trypsinogens by cathepsin B and acidic pH Digestion (1985) 32, 176-177.
Rasnick,D. Synthesis of peptide fluoromethyl ketones and the inhibition of human cathepsin B Anal Biochem (1985) 149, 461-465. PubMed Europe PubMed I
[YEAR:11-2-1985]Ritonja,A., Popovic,T., Turk,V., Wiedenmann,K. and Machleidt,W. Amino acid sequence of human liver cathepsin B FEBS Lett (11-2-1985) 181, 169-172. PubMed Europe PubMed DOI
San Segundo,B., Chan,S.J. and Steiner,D.F. Identification of cDNA clones encoding a precursor of rat liver cathepsin B Proc Natl Acad Sci U S A (1985) 82, 2320-2324. PubMed Europe PubMed PMC EPMC

1984

Hirao,T., Hara,K. and Takahashi,K. Purification and characterization of cathepsin B from monkey skeletal muscle J Biochem (1984) 95, 871-879. PubMed Europe PubMed
Takahashi,T., Schmidt,P.G. and Tang,J. Novel carbohydrate structures of cathepsin B from porcine spleen J Biol Chem (1984) 259, 6059-6062. PubMed Europe PubMed
[YEAR:15-9-1984]Willenbrock,F. and Brocklehurst,K. Natural structural variation in enzymes as a tool in the study of mechanism exemplified by a comparison of the catalytic-site structure and characteristics of cathepsin B and papain. pH-dependent kinetics of the reactions of cathepsin B from bovine spleen and from rat liver with a thiol-specific two-protonic-state probe (2,2'-dipyridyl disulphide) and with a specific synthetic substrate (N-alpha-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide) Biochem J (15-9-1984) 222, 805-814. PubMed Europe PubMed PMC EPMC

1983

[YEAR:10-2-1983]Bajkowski,A.S. and Frankfater,A. The pH dependency of bovine spleen cathepsin B-catalyzed transfer of N alpha-benzyloxycarbonyl-L-lysine from p-nitrophenol to water and dipeptide nucleophiles. Comparisons with papain J Biol Chem (10-2-1983) 258, 1650-1655. PubMed Europe PubMed
[YEAR:10-2-1983]Bajkowski,A.S. and Frankfater,A. Steady state kinetic evidence for an acyl-enzyme intermediate in reactions catalyzed by bovine spleen cathepsin B J Biol Chem (10-2-1983) 258, 1645-1649. PubMed Europe PubMed
[YEAR:10-9-1983]Evans,B. and Shaw,E. Inactivation of cathepsin B by active site-directed disulfide exchange. Application in covalent affinity chromatography J Biol Chem (10-9-1983) 258, 10227-10232. PubMed Europe PubMed
McKay,M.J., Offermann,M.K., Barrett,A.J. and Bond,J.S. Action of human liver cathepsin B on the oxidized insulin B chain Biochem J (1983) 213, 467-471. PubMed Europe PubMed PMC EPMC
[YEAR:15-4-1983]Shaw,E., Wikstrom,P. and Ruscica,J. An exploration of the primary specificity site of cathepsin B Arch Biochem Biophys (15-4-1983) 222, 424-429. PubMed Europe PubMed I
Takio,K., Towatari,T., Katunuma,N., Teller,D.C. and Titani,K. Homology of amino acid sequences of rat liver cathepsins B and H with that of papain Proc Natl Acad Sci U S A (1983) 80, 3666-3670. PubMed Europe PubMed PMC EPMC

1982

Baici,A. and Gyger-Marazzi,M. The slow, tight-binding inhibition of cathepsin B by leupeptin. A hysteretic effect Eur J Biochem (1982) 129, 33-41. PubMed Europe PubMed I
Barrett,A.J., Kembhavi,A.A., Brown,M.A., Kirschke,H., Knight,C.G., Tamai,M. and Hanada,K. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L Biochem J (1982) 201, 189-198. PubMed Europe PubMed PMC EPMC I
[YEAR:1-6-1982]Pohl,J., Baudys,M., Tomasek,V. and Kostka,V. Identification of the active site cysteine and of the disulfide bonds in the N-terminal part of the molecule of bovine spleen cathepsin B FEBS Lett (1-6-1982) 142, 23-26. PubMed Europe PubMed
Recklies,A.D., Mort,J.S. and Poole,A.R. Secretion of a thiol proteinase from mouse mammary carcinomas and its characterization Cancer Res (1982) 42, 1026-1032. PubMed Europe PubMed

1981

Barrett,A.J. and Kirschke,H. Cathepsin B, cathepsin H and cathepsin L Methods Enzymol (1981) 80, 535-561. PubMed Europe PubMed DOI V
Shaw,E. and Kettner,C. The specificity of cathepsin B Acta Biol Med Ger (1981) 40, 1503-1511. PubMed Europe PubMed

1980

Barrett,A.J. Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates Biochem J (1980) 187, 909-912. PubMed Europe PubMed PMC EPMC A
Bond,J.S. and Barrett,A.J. Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. A further example of peptidyldipeptidase activity of this proteinase Biochem J (1980) 189, 17-25. PubMed Europe PubMed PMC EPMC
Butterworth,J. and Duncan,J.J. The hydrolysis of N-benzoyl-L-phenylalanyl-L-valyl-L-arginine- p-nitroanilide and its use as a substrate for the assay of cathepsin B Anal Biochem (1980) 106, 156-162. PubMed Europe PubMed A
[YEAR:1-9-1980]Knight,C.G. Human cathepsin B. Application of the substrate N-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide to a study of the inhibition by leupeptin Biochem J (1-9-1980) 189, 447-453. PubMed Europe PubMed PMC EPMC
[YEAR:17-11-1980]Takio,K., Towatari,T., Katunuma,N. and Titani,K. Primary structure study of rat liver cathepsin B - a striking resemblance to papain Biochem Biophys Res Commun (17-11-1980) 97, 340-346. PubMed Europe PubMed

1979

Inaba,T., Hirayama,Y. and Fujinaga,N. Inhibition of cathepsin B1 by E-64, a thiol proteinase inhibitor, and its derivatives Agric Biol Chem (1979) 43, 655-656. DOI I
Towatari,T., Kawabata,Y. and Katunuma,N. Crystallization and properties of cathepsin B from rat liver Eur J Biochem (1979) 102, 279-289. PubMed Europe PubMed
[YEAR:28-8-1979]Watanabe,H., Green,G.D. and Shaw,E. A comparison of the behavior of chymotrypsin and cathepsin B towards peptidyl diazomethyl ketones Biochem Biophys Res Commun (28-8-1979) 89, 1354-1360. PubMed Europe PubMed I

1978

Aronson,N.N., Jr. and Barrett,A.J. The specificity of cathepsin B. Hydrolysis of glucagon at the C- terminus by a peptidyldipeptidase mechanism Biochem J (1978) 171, 759-765. PubMed Europe PubMed PMC EPMC P
Towatari,T. and Katunuma,N. Crystallization and amino acid composition of cathepsin B from rat liver lysosomes Biochem Biophys Res Commun (1978) 83, 513-520. PubMed Europe PubMed

1977

[YEAR:7-12-1977]Leary,R. and Shaw,E. Inactivation of cathepsin B1 by diazomethyl ketones Biochem Biophys Res Commun (7-12-1977) 79, 926-931. PubMed Europe PubMed I

1976

Barrett,A.J. An improved color reagent for use in Barrett's assay of cathepsin B Anal Biochem (1976) 76, 374-376. PubMed Europe PubMed A
[YEAR:21-6-1976]Fraki,J.E. Human skin proteases. Separation and characterization of two acid proteases resembling cathepsin B1 and cathepsin D and of an inhibitor of cathepsin B1 Arch Dermatol Res (21-6-1976) 255, 317-330. PubMed Europe PubMed

1975

Bajkowski,A.S. and Frankfater,A. Specific spectrophotometric assays for cathepsin B1 Anal Biochem (1975) 68, 119-127. PubMed Europe PubMed A
Keilova,H. and Tomasek,V. Inhibition of cathepsin C by papain inhibitor from chicken egg white and by complex of this inhibitor with cathepsin B1 Collect Czech Chem Commun (1975) 40, 218-224.
McDonald,J.K. and Ellis,S. On the substrate specificity of cathepsins B1 and B2 including a new fluorogenic substrate for cathepsin B1 Life Sci (1975) 17, 1269-1276. PubMed Europe PubMed
Otto,K. and Riesenkonig,H. Improved purification of cathepsin B1 and cathepsin B2 Biochim Biophys Acta (1975) 379, 462-475. PubMed Europe PubMed

1974

Burleigh,M.C., Barrett,A.J. and Lazarus,G.S. Cathepsin B1. A lysosomal enzyme that degrades native collagen Biochem J (1974) 137, 387-398. PubMed Europe PubMed PMC EPMC
Etherington,D.J. The purification of bovine cathepsin B1 and its mode of action on bovine collagens Biochem J (1974) 137, 547-557. PubMed Europe PubMed PMC EPMC
Keilova,H. and Tomasek,V. Effect of papain inhibitor from chicken egg white on cathepsin B1 Biochim Biophys Acta (1974) 334, 179-186.

1973

Barrett,A.J. Human cathepsin B1. Purification and some properties of the enzyme Biochem J (1973) 131, 809-822. PubMed Europe PubMed PMC EPMC
[YEAR:1-2-1973]Keilova,H. and Tomasek,V. On the isozymes of cathepsin B(1) FEBS Lett (1-2-1973) 29, 335-338. PubMed Europe PubMed

1972

Barrett,A.J. A new assay for cathepsin B1 and other thiol proteinases Anal Biochem (1972) 47, 280-293. PubMed Europe PubMed DOI A
De Lumen,B.O. and Tappel,A.L. Continuous fluorometric assay for cathepsin B-like activity in lysosomes Anal Biochem (1972) 48, 378-385. PubMed Europe PubMed A
Iodice,A.A., Chin,J., Perker,S. and Weinstock,I.M. Cathepsins A, B, C, D and autolysis during development of breast muscle of normal and dystrophic chickens Arch Biochem Biophys (1972) 152, 166-174. PubMed Europe PubMed

1971

Otto,K. Cathepsins B1 and B2 (1971) , 1-28.

1970

[YEAR:11-12-1970]Keilova,H. and Turkova,J. Analogy between active sites of cathepsin B1 and papain FEBS Lett (11-12-1970) 11, 287-288. PubMed Europe PubMed

1959

Greenbaum,L.M., Hirshkowitz,A. and Shoichet,I. The activation of trypsinogen by cathepsin B J Biol Chem (1959) 234, 2885-2890. PubMed Europe PubMed

1958

Fujii,S. and Fruton,J.S. Transamidation reactions catalyzed by cathepsins J Biol Chem (1958) 230, 1-11. PubMed Europe PubMed

1957

Greenbaum,L.M. and Fruton,J.S. Purification and properties of beef spleen cathepsin B J Biol Chem (1957) 226, 173-180. PubMed Europe PubMed

1941

Fruton,J.S., Irving,G.W., Jr. and Bergmann,M. On the proteolytic enzymes of animal tissues. III. The proteolytic enzymes of beef spleen, beef kidney and swine kidney. Classification of the cathepsins J Biol Chem (1941) 141, 763-774.