PDBsum entry 2dc7

Hydrolase

PDB id: 2dc7

Contents

Protein chain

251 a.a. *

Ligands

PO4

042

GOL

Waters ×227

* Residue conservation analysis

PDB id:

2dc7

Name:

Hydrolase

Title:

X-ray crystal structure analysis of bovine spleen cathepsin b-ca042 complex

Structure:

Cathepsin b. Chain: a. Ec: 3.4.22.1

Source:

Bos taurus. Cattle. Organism_taxid: 9913. Tissue: spleen

Resolution:

1.94Å R-factor: 0.187 R-free: 0.214

Authors:

D.Watanabe

Key ref:

D.Watanabe et al. Quantitative estimation of each active subsite of cathepsin b for the inhibitory activity, Based on the inhibitory activitybinding mode relationship of a series of epoxysuccinyl inhibitors by x-Ray crystal structure analyses of the complexes. To be published, .

Date:

31-Dec-05 Release date: 24-Jan-06

Protein chain

P07688  (CATB_BOVIN) -  Cathepsin B from Bos taurus

Seq: 335 a.a.

Struc: 251 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.22.1 - cathepsin B.
• Reaction: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.