Structure for peptidase A02.008: murine leukemia virus-type retropepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
3SM2	Moloney murine leukemia virus	1.75 Å	peptidase domain only; complex with amprenavir
The dimer is shown. The active site residue Asp566 is shown in ball-and-stick representation in pink (one for each monomer). A bound amprenavir inhibitor is shown in grey in ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Moloney murine leukemia virus
mature peptidase	3.00 Å	1D0E	1D0E	1D0E	1D0E	1D0E	1D0E	Najmudin et al., 2000
mature peptidase	2.30 Å	1D1U	1D1U	1D1U	1D1U	1D1U	1D1U	Cote et al., 2000
mature peptidase	2.00 Å	1I6J	1I6J	1I6J	1I6J	1I6J	1I6J	Cote & Georgiadis, 2001
mature peptidase	1.80 Å	1MML	1MML	1MML	1MML	1MML	1MML	Georgiadis et al., 1995
mature peptidase	2.00 Å	1N4L	1N4L	1N4L	1N4L	1N4L	1N4L	Cote et al., 2003
mature peptidase	2.30 Å	1NND	1NND	1NND	1NND	1NND	1NND	Crowther et al., 2004
mature peptidase	2.30 Å	1QAI	1QAI	1QAI	1QAI	1QAI	1QAI	Najmudin et al., 2000
mature peptidase	2.30 Å	1QAJ	1QAJ	1QAJ	1QAJ	1QAJ	1QAJ	Najmudin et al., 2000
mature peptidase	1.85 Å	1ZTT	1ZTT	1ZTT	1ZTT	1ZTT	1ZTT	Goodwin et al., 2005
mature peptidase	1.80 Å	1ZTW	1ZTW	1ZTW	1ZTW	1ZTW	1ZTW	Goodwin et al., 2005
mature peptidase	2.05 Å	2FJV	2FJV	2FJV	2FJV	2FJV	2FJV	Goodwin et al., 2006
mature peptidase	1.95 Å	2FJW	2FJW	2FJW	2FJW	2FJW	2FJW	Goodwin et al., 2006
mature peptidase	1.80 Å	2FJX	2FJX	2FJX	2FJX	2FJX	2FJX	Goodwin et al., 2006
mature peptidase	2.25 Å	2FVP	2FVP	2FVP	2FVP	2FVP	2FVP	Montano et al., 2006
mature peptidase	2.30 Å	2FVQ	2FVQ	2FVQ	2FVQ	2FVQ	2FVQ	Montano et al., 2006
mature peptidase	2.20 Å	2FVR	2FVR	2FVR	2FVR	2FVR	2FVR	Montano et al., 2006
mature peptidase	2.35 Å	2FVS	2FVS	2FVS	2FVS	2FVS	2FVS	Montano et al., 2006
mature peptidase	1.59 Å	2HB5	2HB5	2HB5	2HB5	2HB5	2HB5	Lim et al., 2006
mature peptidase	0.00 Å	2M9U	2M9U	2M9U	2M9U	2M9U	2M9U	Aiyer et al., 2014
mature peptidase	0.00 Å	2MQV	2MQV	2MQV	2MQV	2MQV	2MQV	Miller et al., 2014
mature peptidase	0.00 Å	2MS0	2MS0	2MS0	2MS0	2MS0	2MS0	Miller et al., 2014
mature peptidase	0.00 Å	2MS1	2MS1	2MS1	2MS1	2MS1	2MS1	Miller et al., 2014
mature peptidase	2.10 Å	2R2R	2R2R	2R2R	2R2R	2R2R	2R2R	Goodwin et al., 2008
mature peptidase	2.80 Å	2R2S	2R2S	2R2S	2R2S	2R2S	2R2S	Goodwin et al., 2008
mature peptidase	2.00 Å	2R2T	2R2T	2R2T	2R2T	2R2T	2R2T	Goodwin et al., 2008
mature peptidase	2.30 Å	2R2U	2R2U	2R2U	2R2U	2R2U	2R2U	Goodwin et al., 2008
mature peptidase	1.75 Å	3FSI	3FSI	3FSI	3FSI	3FSI	3FSI	Glass et al., 2009
mature peptidase	2.69 Å	3NNQ	3NNQ	3NNQ	3NNQ	3NNQ	3NNQ
peptidase domain only; complex with TL-3	1.40 Å	3SLZ	3SLZ	3SLZ	3SLZ	3SLZ	3SLZ	Li et al., 2011
peptidase domain only; complex with pepstatin	1.50 Å	3SM1	3SM1	3SM1	3SM1	3SM1	3SM1	Li et al., 2011
peptidase domain only; complex with amprenavir	1.75 Å	3SM2	3SM2	3SM2	3SM2	3SM2	3SM2	Li et al., 2011
complex with acetyl-pepstatin	2.00 Å	4EXH	4EXH	4EXH	4EXH	4EXH	4EXH
mature peptidase	2.14 Å	4M94	4M94	4M94	4M94	4M94	4M94	Singh et al., 2014
mature peptidase	1.72 Å	4M95	4M95	4M95	4M95	4M95	4M95	Singh et al., 2014
mature peptidase	3.00 Å	4MH8	4MH8	4MH8	4MH8	4MH8	4MH8	Das & Georgiadis, 2004
mature peptidase	2.15 Å	4NZG	4NZG	4NZG	4NZG	4NZG	4NZG
mature peptidase	1.70 Å	4XO0	4XO0	4XO0	4XO0	4XO0	4XO0
mature peptidase	1.68 Å	4XPC	4XPC	4XPC	4XPC	4XPC	4XPC
mature peptidase	1.78 Å	4XPE	4XPE	4XPE	4XPE	4XPE	4XPE
Murine leukemia-related retroviruses
mature peptidase	1.97 Å	3NR6	3NR6	3NR6	3NR6	3NR6	3NR6	Li et al., 2011
mature peptidase	1.50 Å	3P1G	3P1G	3P1G	3P1G	3P1G	3P1G	Kirby et al., 2012
mature peptidase	2.60 Å	4E89	4E89	4E89	4E89	4E89	4E89	Kim et al., 2012
mature peptidase	3.04 Å	4HKQ	4HKQ	4HKQ	4HKQ	4HKQ	4HKQ	Nowak et al., 2013