$VAR1 = undef;

Summary for peptidase A02.008: murine leukemia virus-type retropepsin

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.008
Holotype	murine leukemia virus-type retropepsin (Moloney murine leukemia virus), Uniprot accession P03355 (peptidase unit: 535-659), MERNUM MER0001480
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00030
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (5 cleavages)
Physiology	Processing of viral polyprotein.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	S/q/N/YlftP/Il/V/Q (based on 20 cleavages)

Specificity matrix

Amino acid P4 P3 P2 P1 P1' P2' P3' P4' Gly 0 1 0 0 0 0 0 0 Pro 0 0 1 0 14 0 0 0 Ala 1 1 2 0 0 1 0 0 Val 0 1 3 0 1 0 12 0 Leu 2 3 2 4 0 5 1 1 Ile 2 1 0 1 0 12 1 1 Met 0 0 0 1 1 0 1 0 Phe 0 1 0 2 0 0 0 0 Tyr 0 0 0 10 0 0 0 0 Trp 0 0 0 0 0 0 0 0 Ser 14 1 0 0 0 0 1 1 Thr 1 1 0 2 2 1 0 3 Cys 0 0 0 0 0 0 0 0 Asn 0 0 12 0 0 1 1 0 Gln 0 9 0 0 0 0 1 12 Asp 0 0 0 0 0 0 0 1 Glu 0 0 0 0 2 0 1 1 Lys 0 1 0 0 0 0 0 0 Arg 0 0 0 0 0 0 1 0 His 0 0 0 0 0 0 0 0

Mouse genetics
Gene symbol	Position	Megabases	Ensembl	Entrez gene	MGI
Mela	8 E1		ENSMUSG00000074036	17276	MGI:107565

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