Structure for peptidase A02.007: feline immunodeficiency virus retropepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

PDB Organism Resolution Comment
3FIV feline immunodeficiency virus 1.85 Å complex with Ac-naphthylAla-Val-Leu-Ala-Glu-naphthylaminoAla substrate
The dimer is shown. The active site residue Asp68 (engineered to be Asn) is shown in ball-and-stick representation in pink (one from each monomer). Bound inhibitor is shown in grey in ball-and-stick representation.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
feline immunodeficiency virus
complex with TL-3-093 inhibitor 1.90 Å 1B11 1B11 1B11 1B11 1B11 1B11 Li et al., 2000
complex with acAla-Val-Sta-Glu-Ala-NH2 2.00 Å 1FIV 1FIV 1FIV 1FIV 1FIV 1FIV Wlodawer et al., 1995
complex with Ac-naphylAla-Val-Sta-Glu-naphthylaminoAla substrate 2.00 Å 2FIV 2FIV 2FIV 2FIV 2FIV 2FIV Laco et al., 1997
complex with tl-3 1.70 Å 2HAH 2HAH 2HAH 2HAH 2HAH 2HAH
complex with Ac-naphthylAla-Val-Leu-Ala-Glu-naphthylaminoAla substrate 1.85 Å 3FIV 3FIV 3FIV 3FIV 3FIV 3FIV Laco et al., 1997
complex with darunavir 1.70 Å 3OGP 3OGP 3OGP 3OGP 3OGP 3OGP
complex with lopinavir 1.80 Å 3OGQ 3OGQ 3OGQ 3OGQ 3OGQ 3OGQ
complex with LP-130 inhibitor 1.80 Å 4FIV 4FIV 4FIV 4FIV 4FIV 4FIV Kervinen et al., 1998
complex with TL-3-093 inhibitor 1.90 Å 5FIV 5FIV 5FIV 5FIV 5FIV 5FIV Li et al., 2000
complex with TL-3-093 inhibitor 1.90 Å 6FIV 6FIV 6FIV 6FIV 6FIV 6FIV Li et al., 2000